CRISPLD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.57192820
2protein heterotrimerization (GO:0070208)5.16938559
3hemidesmosome assembly (GO:0031581)4.91042721
4blood vessel maturation (GO:0001955)4.36034038
5keratan sulfate catabolic process (GO:0042340)4.27874169
6negative regulation of complement activation (GO:0045916)4.25500052
7collagen fibril organization (GO:0030199)4.10683307
8peptidyl-proline hydroxylation (GO:0019511)4.10523522
9retina vasculature morphogenesis in camera-type eye (GO:0061299)4.08624966
10dermatan sulfate biosynthetic process (GO:0030208)4.06952161
11glomerular basement membrane development (GO:0032836)4.06348770
12endodermal cell differentiation (GO:0035987)4.02257398
13negative regulation of cardiac muscle tissue growth (GO:0055022)3.88575292
14negative regulation of heart growth (GO:0061117)3.88575292
15renal filtration (GO:0097205)3.88252061
16skin morphogenesis (GO:0043589)3.85297275
17regulation of macrophage cytokine production (GO:0010935)3.83675672
18detection of molecule of bacterial origin (GO:0032490)3.82385521
19glomerular filtration (GO:0003094)3.81274797
20growth hormone receptor signaling pathway (GO:0060396)3.81232917
21dermatan sulfate metabolic process (GO:0030205)3.76681292
22pattern specification involved in kidney development (GO:0061004)3.75791538
23collagen metabolic process (GO:0032963)3.69162748
24cell migration involved in heart development (GO:0060973)3.68259739
25collagen catabolic process (GO:0030574)3.66811285
26cell adhesion mediated by integrin (GO:0033627)3.65585651
27basement membrane organization (GO:0071711)3.60412686
28bone trabecula formation (GO:0060346)3.59476315
29mesodermal cell differentiation (GO:0048333)3.55945532
30extracellular matrix disassembly (GO:0022617)3.55087381
31multicellular organismal macromolecule metabolic process (GO:0044259)3.53601909
32myelination in peripheral nervous system (GO:0022011)3.51091314
33peripheral nervous system axon ensheathment (GO:0032292)3.51091314
34mesenchymal-epithelial cell signaling (GO:0060638)3.47376597
35protein hydroxylation (GO:0018126)3.44706921
36interleukin-6-mediated signaling pathway (GO:0070102)3.44219198
37multicellular organismal catabolic process (GO:0044243)3.43807215
38atrioventricular valve morphogenesis (GO:0003181)3.40389750
394-hydroxyproline metabolic process (GO:0019471)3.39600360
40heart trabecula formation (GO:0060347)3.39176669
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.36704104
42multicellular organismal metabolic process (GO:0044236)3.35197611
43extracellular fibril organization (GO:0043206)3.35051898
44negative regulation of protein activation cascade (GO:2000258)3.33439907
45trabecula formation (GO:0060343)3.32701764
46cellular response to growth hormone stimulus (GO:0071378)3.28812745
47regulation of endothelial cell differentiation (GO:0045601)3.28138748
48gas transport (GO:0015669)3.26920957
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.22994672
50vascular endothelial growth factor signaling pathway (GO:0038084)3.20428754
51opsonization (GO:0008228)3.19976326
52lung lobe morphogenesis (GO:0060463)3.07883826
53type B pancreatic cell proliferation (GO:0044342)3.06943949
54positive regulation of p38MAPK cascade (GO:1900745)3.03553510
55lymph vessel development (GO:0001945)3.02783550
56cellular extravasation (GO:0045123)3.01316397
57extracellular matrix assembly (GO:0085029)3.00354008
58epithelial cell-cell adhesion (GO:0090136)2.98969625
59fibril organization (GO:0097435)2.96793700
60chondroitin sulfate catabolic process (GO:0030207)2.96060045
61cell-substrate junction assembly (GO:0007044)2.95532118
62regulation of p38MAPK cascade (GO:1900744)2.95078533
63branching involved in salivary gland morphogenesis (GO:0060445)2.93915909
64platelet-derived growth factor receptor signaling pathway (GO:0048008)2.92778969
65endothelial cell morphogenesis (GO:0001886)2.92382654
66* extracellular matrix organization (GO:0030198)2.90383356
67modulation by symbiont of host immune response (GO:0052553)2.90342601
68positive regulation by symbiont of host defense response (GO:0052509)2.90342601
69modulation by symbiont of host defense response (GO:0052031)2.90342601
70modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90342601
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90342601
72positive regulation by organism of defense response of other organism involved in symbiotic interact2.90342601
73regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.89820614
74* extracellular structure organization (GO:0043062)2.89268806
75endocardial cushion morphogenesis (GO:0003203)2.88862117
76sequestering of extracellular ligand from receptor (GO:0035581)2.88609205
77negative regulation of smooth muscle cell migration (GO:0014912)2.86988814
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85321448
79detection of external biotic stimulus (GO:0098581)2.84929412
80cardiac epithelial to mesenchymal transition (GO:0060317)2.80041793
81tooth mineralization (GO:0034505)2.79999233
82positive regulation of macrophage cytokine production (GO:0060907)2.78831435
83positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.78151459
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76831377
85endothelial cell proliferation (GO:0001935)2.76607123
86wound healing (GO:0042060)2.76463638
87regulation of SMAD protein import into nucleus (GO:0060390)2.75145192
88smooth muscle tissue development (GO:0048745)2.73638769
89bundle of His cell to Purkinje myocyte communication (GO:0086069)2.72964791
90negative regulation of humoral immune response (GO:0002921)2.72348078
91regulation of T-helper 2 cell differentiation (GO:0045628)2.72176163
92epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.69223368
93negative regulation of T-helper cell differentiation (GO:0045623)2.67880601
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.67880601
95cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.67841940
96positive regulation of osteoblast proliferation (GO:0033690)2.66900126
97barbed-end actin filament capping (GO:0051016)2.63661751
98angiogenesis involved in wound healing (GO:0060055)2.61190044
99cardiac myofibril assembly (GO:0055003)2.59063943
100gland morphogenesis (GO:0022612)2.58772058
101peptide cross-linking (GO:0018149)2.58671862
102fibroblast migration (GO:0010761)2.57821902
103wound healing, spreading of epidermal cells (GO:0035313)2.57741376
104negative regulation of fatty acid transport (GO:2000192)2.55433428
105import into cell (GO:0098657)2.54149703
106mesenchyme morphogenesis (GO:0072132)2.53394926
107negative regulation of T cell differentiation in thymus (GO:0033085)2.53313849
108iron ion import (GO:0097286)2.53203563
109chondroitin sulfate biosynthetic process (GO:0030206)2.51828211
110hypotonic response (GO:0006971)2.50930932
111cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.50245586
112macrophage activation involved in immune response (GO:0002281)2.49647851
113phagocytosis, recognition (GO:0006910)2.49349047
114metanephric mesenchyme development (GO:0072075)2.48858649
115pathway-restricted SMAD protein phosphorylation (GO:0060389)2.47567778
116chondrocyte development (GO:0002063)2.47302170
117positive regulation of chemokine secretion (GO:0090197)2.46369770
118positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.46186328
119positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.46177412
120lung vasculature development (GO:0060426)2.45697118
121cellular response to cadmium ion (GO:0071276)2.45185955
122ventricular septum morphogenesis (GO:0060412)2.44297248
123antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44103664
124regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.44069914
125response to nitric oxide (GO:0071731)2.43508783
126cardiac muscle cell proliferation (GO:0060038)2.42377782
127response to laminar fluid shear stress (GO:0034616)2.42026722
128chondrocyte proliferation (GO:0035988)2.41938480
129camera-type eye morphogenesis (GO:0048593)2.41830409
130sarcomere organization (GO:0045214)2.40988576
131detection of biotic stimulus (GO:0009595)2.40630495
132detection of other organism (GO:0098543)2.39572755
133endocardial cushion development (GO:0003197)2.39531094
134response to fluid shear stress (GO:0034405)2.39065347
135endocrine hormone secretion (GO:0060986)2.38086765
136pericardium development (GO:0060039)2.38084933
137positive regulation of fibroblast migration (GO:0010763)2.37685438
138response to interferon-alpha (GO:0035455)2.37364871
139negative regulation of protein autophosphorylation (GO:0031953)2.34090717
140negative regulation of interleukin-8 production (GO:0032717)2.33327639
141leukocyte migration involved in inflammatory response (GO:0002523)2.33059050
142response to peptidoglycan (GO:0032494)2.31593731
143regulation of fibroblast migration (GO:0010762)2.29770334
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.29533555
145negative regulation of cell killing (GO:0031342)2.29533555
146regulation of dendritic cell antigen processing and presentation (GO:0002604)2.27076864
147neutrophil mediated immunity (GO:0002446)2.23621963
148antigen processing and presentation of endogenous antigen (GO:0019883)2.23606612
149negative regulation of interleukin-12 production (GO:0032695)2.21384837
150response to increased oxygen levels (GO:0036296)2.19081676
151response to hyperoxia (GO:0055093)2.19081676
152positive regulation of macrophage activation (GO:0043032)2.18468747
153regulation of integrin-mediated signaling pathway (GO:2001044)2.18072354
154kidney mesenchyme development (GO:0072074)2.17296447
155antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.16526732
156cellular response to epinephrine stimulus (GO:0071872)2.15600075
157regulation of interferon-beta biosynthetic process (GO:0045357)2.15113538
158regulation of chemokine secretion (GO:0090196)2.14472219
159ovulation from ovarian follicle (GO:0001542)2.13999143
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.10603083
161positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.10390242
162detection of bacterium (GO:0016045)2.09538340
163UDP-N-acetylglucosamine metabolic process (GO:0006047)2.09210649
164macrophage activation (GO:0042116)2.07989986
165response to host defenses (GO:0052200)2.06173265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.01623936
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.71537908
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.79679668
4CLOCK_20551151_ChIP-Seq_293T_Human2.93829017
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.88922580
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67966675
7ZNF263_19887448_ChIP-Seq_K562_Human2.67553939
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.63358119
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.60840769
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.56568237
11* ESR2_21235772_ChIP-Seq_MCF-7_Human2.55183705
12* ESR1_21235772_ChIP-Seq_MCF-7_Human2.49967259
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35413345
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25571173
15AR_21572438_ChIP-Seq_LNCaP_Human2.18160262
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17317297
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17311822
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.14210796
19* CJUN_26792858_Chip-Seq_BT549_Human2.11952527
20* EP300_21415370_ChIP-Seq_HL-1_Mouse2.10710317
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10326797
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.95520448
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92070119
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86338202
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.83955088
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.83930904
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78541304
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76115300
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75670649
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72274396
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70660526
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.69686682
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69317861
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68360429
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66227539
36* VDR_24787735_ChIP-Seq_THP-1_Human1.64527612
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62393898
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.58450079
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.58303265
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57894375
41* TBX20_22080862_ChIP-Seq_HEART_Mouse1.57088307
42* TBX20_22328084_ChIP-Seq_HEART_Mouse1.57088307
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51829663
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49012183
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48637781
46SOX2_20726797_ChIP-Seq_SW620_Human1.44065615
47RUNX_20019798_ChIP-Seq_JUKART_Human1.43318926
48GBX2_23144817_ChIP-Seq_PC3_Human1.42739065
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.39253904
50* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38822274
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38011044
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38011044
53* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36516475
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34983019
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34782984
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34782984
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34447657
58RACK7_27058665_Chip-Seq_MCF-7_Human1.33295325
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33167098
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31214255
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30686971
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30371884
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30371884
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27750904
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.25953605
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25228735
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.25075409
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23564814
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23143923
70* BRD4_25478319_ChIP-Seq_HGPS_Human1.21658186
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20256212
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19385448
73* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19213243
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.19061081
75* AHR_22903824_ChIP-Seq_MCF-7_Human1.18326290
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18265444
77DROSHA_22980978_ChIP-Seq_HELA_Human1.17013769
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15101077
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14777437
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13815764
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13153657
82KDM2B_26808549_Chip-Seq_K562_Human1.10108617
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10020782
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09911660
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09893274
86LXR_22292898_ChIP-Seq_THP-1_Human1.08488946
87LXR_22158963_ChIP-Seq_LIVER_Mouse1.07494153
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.02705117
89* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02127374
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01361894
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00847438
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00815783
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00499519
94ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99837991
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.99313918
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99123653
97TP53_16413492_ChIP-PET_HCT116_Human0.97922399
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97827921
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97139154
100* TP63_23658742_ChIP-Seq_EP156T_Human0.95965798
101IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95043628
102TP53_18474530_ChIP-ChIP_U2OS_Human0.94648588
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94408500
104* ARNT_22903824_ChIP-Seq_MCF-7_Human0.94238149
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93650555
106TCF4_18268006_ChIP-ChIP_LS174T_Human0.93482127
107* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93370746
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93080353
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92632115
110* RUNX1_27514584_Chip-Seq_MCF-7_Human0.92272419
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91801157
112KLF5_25053715_ChIP-Seq_YYC3_Human0.90623798
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90276165
114SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89957434
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.89786146
116BCAT_22108803_ChIP-Seq_LS180_Human0.89413284
117MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88948390
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.88944883
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88753570
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.88660462
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88560581
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88488569
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88355264
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88082451
125SPI1_23127762_ChIP-Seq_K562_Human0.87902855
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87882892
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87493869
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87275813
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87223747
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87182125
131FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84513172
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83923306
133GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83806513
134ATF3_27146783_Chip-Seq_COLON_Human0.83584681
135SCL_19346495_ChIP-Seq_HPC-7_Human0.83564195
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83547436
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83259937
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82197302
139MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80849993
140SMAD4_21799915_ChIP-Seq_A2780_Human0.80035636
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77314068
142* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77054826
143KDM2B_26808549_Chip-Seq_REH_Human0.76449721
144FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76041487
145RXR_22108803_ChIP-Seq_LS180_Human0.75906032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.13521943
2MP0005275_abnormal_skin_tensile5.62840875
3MP0005503_abnormal_tendon_morphology5.46140110
4MP0004272_abnormal_basement_membrane3.44271470
5MP0001958_emphysema3.00723934
6MP0004084_abnormal_cardiac_muscle2.82513498
7MP0002254_reproductive_system_inflammat2.67764274
8MP0000751_myopathy2.66787803
9MP0006054_spinal_hemorrhage2.54583469
10MP0003279_aneurysm2.49777590
11MP0003566_abnormal_cell_adhesion2.47381782
12MP0003705_abnormal_hypodermis_morpholog2.38941159
13MP0010368_abnormal_lymphatic_system2.22805206
14MP0000750_abnormal_muscle_regeneration2.21998839
15MP0002060_abnormal_skin_morphology2.13182373
16MP0002108_abnormal_muscle_morphology2.12018887
17MP0008004_abnormal_stomach_pH1.93319826
18MP0005023_abnormal_wound_healing1.93007900
19MP0004036_abnormal_muscle_relaxation1.89045760
20MP0003436_decreased_susceptibility_to1.84131209
21MP0002837_dystrophic_cardiac_calcinosis1.83632678
22MP0001879_abnormal_lymphatic_vessel1.80265227
23MP0005508_abnormal_skeleton_morphology1.78588426
24MP0003045_fibrosis1.51627357
25MP0001986_abnormal_taste_sensitivity1.50947399
26MP0000767_abnormal_smooth_muscle1.48237366
27MP0002282_abnormal_trachea_morphology1.47519653
28MP0005330_cardiomyopathy1.46629716
29MP0005623_abnormal_meninges_morphology1.45186841
30MP0003950_abnormal_plasma_membrane1.43381989
31MP0003300_gastrointestinal_ulcer1.32152722
32MP0002419_abnormal_innate_immunity1.28445045
33MP0000013_abnormal_adipose_tissue1.27882316
34MP0000343_altered_response_to1.27312349
35MP0003828_pulmonary_edema1.25722222
36MP0002295_abnormal_pulmonary_circulatio1.25380339
37MP0002933_joint_inflammation1.23856591
38MP0006082_CNS_inflammation1.21478826
39MP0004484_altered_response_of1.21465254
40MP0000003_abnormal_adipose_tissue1.19176301
41MP0001544_abnormal_cardiovascular_syste1.18781248
42MP0005385_cardiovascular_system_phenoty1.18781248
43MP0001849_ear_inflammation1.18224111
44MP0005165_increased_susceptibility_to1.17305866
45MP0003191_abnormal_cellular_cholesterol1.17020927
46MP0001243_abnormal_dermal_layer1.16659247
47MP0004087_abnormal_muscle_fiber1.16603450
48MP0002972_abnormal_cardiac_muscle1.15650195
49MP0000534_abnormal_ureter_morphology1.14454944
50MP0000685_abnormal_immune_system1.14006910
51MP0005387_immune_system_phenotype1.13418069
52MP0001790_abnormal_immune_system1.13418069
53MP0003448_altered_tumor_morphology1.13006639
54MP0004883_abnormal_blood_vessel1.11231878
55MP0005390_skeleton_phenotype1.11030868
56MP0005369_muscle_phenotype1.10479816
57MP0005164_abnormal_response_to1.08409429
58MP0008775_abnormal_heart_ventricle1.08186779
59MP0005620_abnormal_muscle_contractility1.07116022
60MP0010234_abnormal_vibrissa_follicle1.06258355
61MP0001881_abnormal_mammary_gland1.06249401
62MP0009785_altered_susceptibility_to1.05988627
63MP0000749_muscle_degeneration1.05734301
64MP0001835_abnormal_antigen_presentation1.05438761
65MP0010630_abnormal_cardiac_muscle1.02079816
66MP0003011_delayed_dark_adaptation1.01286597
67MP0000858_altered_metastatic_potential1.01050221
68MP0002877_abnormal_melanocyte_morpholog1.00633565
69MP0005257_abnormal_intraocular_pressure0.99712820
70MP0002089_abnormal_postnatal_growth/wei0.98825242
71MP0004947_skin_inflammation0.98573806
72MP0009384_cardiac_valve_regurgitation0.98256786
73MP0003115_abnormal_respiratory_system0.97984166
74MP0000249_abnormal_blood_vessel0.97217552
75MP0003075_altered_response_to0.97011033
76MP0005670_abnormal_white_adipose0.96841031
77MP0003091_abnormal_cell_migration0.96761194
78MP0010352_gastrointestinal_tract_polyps0.95984025
79MP0002106_abnormal_muscle_physiology0.94572385
80MP0001851_eye_inflammation0.94218905
81MP0005025_abnormal_response_to0.93182370
82MP0005595_abnormal_vascular_smooth0.92811865
83MP0001661_extended_life_span0.90569004
84MP0002138_abnormal_hepatobiliary_system0.90429524
85MP0003795_abnormal_bone_structure0.89745992
86MP0002998_abnormal_bone_remodeling0.87953314
87MP0000163_abnormal_cartilage_morphology0.87308686
88MP0009764_decreased_sensitivity_to0.87239312
89MP0002405_respiratory_system_inflammati0.87047679
90MP0006138_congestive_heart_failure0.86779445
91MP0001533_abnormal_skeleton_physiology0.86077228
92MP0005375_adipose_tissue_phenotype0.86000035
93MP0004510_myositis0.85571890
94MP0010386_abnormal_urinary_bladder0.85555076
95MP0005388_respiratory_system_phenotype0.84214215
96MP0002133_abnormal_respiratory_system0.84214215
97MP0000627_abnormal_mammary_gland0.84001729
98MP0009780_abnormal_chondrocyte_physiolo0.83789004
99MP0002896_abnormal_bone_mineralization0.83538935
100MP0000230_abnormal_systemic_arterial0.83297012
101MP0002148_abnormal_hypersensitivity_rea0.83046706
102MP0005000_abnormal_immune_tolerance0.81610688
103MP0009250_abnormal_appendicular_skeleto0.81391624
104MP0000733_abnormal_muscle_development0.78773921
105MP0002128_abnormal_blood_circulation0.78763179
106MP0001270_distended_abdomen0.78250060
107MP0000762_abnormal_tongue_morphology0.78083468
108MP0001542_abnormal_bone_strength0.77490009
109MP0001614_abnormal_blood_vessel0.77168827
110MP0003303_peritoneal_inflammation0.76794052
111MP0001845_abnormal_inflammatory_respons0.76111274
112MP0002925_abnormal_cardiovascular_devel0.76077035
113MP0001800_abnormal_humoral_immune0.75563103
114MP0001175_abnormal_lung_morphology0.75287620
115MP0003567_abnormal_fetal_cardiomyocyte0.74245763
116MP0002132_abnormal_respiratory_system0.74158391
117MP0004215_abnormal_myocardial_fiber0.74007303
118MP0002452_abnormal_antigen_presenting0.73459077
119MP0005197_abnormal_uvea_morphology0.73254295
120MP0002332_abnormal_exercise_endurance0.72185726
121MP0002166_altered_tumor_susceptibility0.72057820
122MP0009278_abnormal_bone_marrow0.71726327
123MP0000759_abnormal_skeletal_muscle0.70138908
124MP0002876_abnormal_thyroid_physiology0.69810432
125MP0002168_other_aberrant_phenotype0.68901414
126MP0003724_increased_susceptibility_to0.68726062
127MP0002723_abnormal_immune_serum0.68565153
128MP0005377_hearing/vestibular/ear_phenot0.68399642
129MP0003878_abnormal_ear_physiology0.68399642
130MP0002115_abnormal_skeleton_extremities0.68295047
131MP0003941_abnormal_skin_development0.67574408
132MP0000747_muscle_weakness0.66731799
133MP0002113_abnormal_skeleton_development0.65386987
134MP0010155_abnormal_intestine_physiology0.64290204
135MP0003646_muscle_fatigue0.64264565
136MP0005076_abnormal_cell_differentiation0.63453884
137MP0000465_gastrointestinal_hemorrhage0.60937962
138MP0002420_abnormal_adaptive_immunity0.59966236
139MP0004130_abnormal_muscle_cell0.59530714
140MP0001819_abnormal_immune_cell0.59433327
141MP0002006_tumorigenesis0.59338978
142MP0000470_abnormal_stomach_morphology0.58453672

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)6.24608614
2Protrusio acetabuli (HP:0003179)5.87172327
3Wrist flexion contracture (HP:0001239)5.72366956
4Ankle contracture (HP:0006466)5.33806480
5Premature rupture of membranes (HP:0001788)5.20186604
6Aortic dissection (HP:0002647)4.80230652
7Atrophic scars (HP:0001075)4.65313829
8Cervical subluxation (HP:0003308)4.49087298
9Round ear (HP:0100830)4.30398615
10Right ventricular cardiomyopathy (HP:0011663)4.28259065
11Aortic aneurysm (HP:0004942)4.21485244
12Shallow orbits (HP:0000586)3.89787303
13Cerebral aneurysm (HP:0004944)3.89526325
14Absent frontal sinuses (HP:0002688)3.77371347
15Mitral stenosis (HP:0001718)3.59508328
16Increased connective tissue (HP:0009025)3.36945847
17Type 1 muscle fiber predominance (HP:0003803)3.10364582
18Vascular tortuosity (HP:0004948)3.05039249
19Arterial tortuosity (HP:0005116)2.97093401
20Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.90284670
21Pulmonary artery stenosis (HP:0004415)2.86605299
22Eczematoid dermatitis (HP:0000976)2.86031088
23Milia (HP:0001056)2.85467192
24Mitral valve prolapse (HP:0001634)2.83793692
25Fragile skin (HP:0001030)2.79765385
26Muscle fiber splitting (HP:0003555)2.79736069
27Metaphyseal dysplasia (HP:0100255)2.77922165
28Gastrointestinal infarctions (HP:0005244)2.77009070
29J-shaped sella turcica (HP:0002680)2.75272848
30Orchitis (HP:0100796)2.73770383
31Soft skin (HP:0000977)2.72904300
32Onycholysis (HP:0001806)2.71305952
33Genu recurvatum (HP:0002816)2.69789679
34Ventricular tachycardia (HP:0004756)2.69636913
35Dilatation of the ascending aorta (HP:0005111)2.66239038
36Myositis (HP:0100614)2.65178104
37Aneurysm (HP:0002617)2.64833967
38Bladder diverticulum (HP:0000015)2.59201882
39Spinal rigidity (HP:0003306)2.58710937
40Tarsal synostosis (HP:0008368)2.57754144
41Short hallux (HP:0010109)2.57737043
42Abnormality of the frontal sinuses (HP:0002687)2.57150146
43Polycythemia (HP:0001901)2.53511884
44Blue sclerae (HP:0000592)2.51919754
45Follicular hyperkeratosis (HP:0007502)2.51905379
46Increased corneal curvature (HP:0100692)2.48819555
47Keratoconus (HP:0000563)2.48819555
48Vertebral compression fractures (HP:0002953)2.48762112
49Osteolytic defects of the hand bones (HP:0009699)2.44504735
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.44504735
51Bronchomalacia (HP:0002780)2.43547007
52Spondylolisthesis (HP:0003302)2.39694804
53Aortic valve stenosis (HP:0001650)2.36644728
54Hematochezia (HP:0002573)2.35179109
55Joint stiffness (HP:0001387)2.35044375
56Gingivitis (HP:0000230)2.31053243
57Aplasia/Hypoplasia of the hallux (HP:0008362)2.30845834
58Sudden death (HP:0001699)2.30734561
59Increased variability in muscle fiber diameter (HP:0003557)2.30229643
60Wide anterior fontanel (HP:0000260)2.28904978
61Ependymoma (HP:0002888)2.26575416
62Abnormality of the peritoneum (HP:0002585)2.24687166
63Synostosis involving bones of the feet (HP:0009140)2.24201019
64Synostosis involving bones of the lower limbs (HP:0009138)2.24201019
65Optic neuritis (HP:0100653)2.21930194
66Retrobulbar optic neuritis (HP:0100654)2.21930194
67Striae distensae (HP:0001065)2.20117885
68Exercise-induced muscle cramps (HP:0003710)2.19502214
69Hyporeflexia of lower limbs (HP:0002600)2.19495965
70Recurrent gram-negative bacterial infections (HP:0005420)2.18023011
71Mildly elevated creatine phosphokinase (HP:0008180)2.16914528
72Tracheal stenosis (HP:0002777)2.13898596
73Abnormality of the calf musculature (HP:0001430)2.13326823
74Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.12538608
75Wormian bones (HP:0002645)2.12258204
76Lipoatrophy (HP:0100578)2.10822956
77Abnormality of primary teeth (HP:0006481)2.10618917
78Abnormality of skull ossification (HP:0002703)2.07714697
79Fragile nails (HP:0001808)2.07549564
80Interstitial pulmonary disease (HP:0006530)2.07348454
81Elevated erythrocyte sedimentation rate (HP:0003565)2.07337686
82Systemic lupus erythematosus (HP:0002725)2.05047037
83Abnormality of skeletal muscle fiber size (HP:0012084)2.04129250
84Abnormality of incisor morphology (HP:0011063)2.04030554
85Hip contracture (HP:0003273)2.01882179
86Decreased skull ossification (HP:0004331)2.01075233
87Corneal dystrophy (HP:0001131)1.99367616
88Keratoconjunctivitis sicca (HP:0001097)1.98266917
89Stomach cancer (HP:0012126)1.97595147
90Enlarged penis (HP:0000040)1.96634871
91Calf muscle hypertrophy (HP:0008981)1.94762971
92Increased IgE level (HP:0003212)1.94594022
93Narrow palate (HP:0000189)1.94103456
94Hypoplasia of the iris (HP:0007676)1.93659691
95Persistence of primary teeth (HP:0006335)1.92804389
96Overgrowth (HP:0001548)1.92633270
97Malnutrition (HP:0004395)1.91239950
98Delayed closure of the anterior fontanelle (HP:0001476)1.90330055
99Thin bony cortex (HP:0002753)1.90088160
100Hemoptysis (HP:0002105)1.89639622
101Keratoconjunctivitis (HP:0001096)1.89329021
102Camptodactyly of toe (HP:0001836)1.88332991
103Rectal prolapse (HP:0002035)1.88209971
104Ectopia lentis (HP:0001083)1.87901453
105Mesomelia (HP:0003027)1.87725907
106Peritonitis (HP:0002586)1.87637196
107Mitral regurgitation (HP:0001653)1.86868353
108Biconcave vertebral bodies (HP:0004586)1.86526182
109Alopecia of scalp (HP:0002293)1.86025282
110Osteopenia (HP:0000938)1.85625030
111Hyperextensible skin (HP:0000974)1.85326610
112Delayed cranial suture closure (HP:0000270)1.84364847
113Abnormality of the pulmonary veins (HP:0011718)1.83746479
114Aortic regurgitation (HP:0001659)1.81418249
115Abnormality of complement system (HP:0005339)1.80823614
116Abnormality of the anterior chamber (HP:0000593)1.77909727
117Flared iliac wings (HP:0002869)1.77568729
118Slender build (HP:0001533)1.77257012
119Spontaneous hematomas (HP:0007420)1.76631894
120Myocardial infarction (HP:0001658)1.76343456
121Atrial fibrillation (HP:0005110)1.76282236
122Osteoarthritis (HP:0002758)1.75722996
123Joint laxity (HP:0001388)1.74876192
124Platyspondyly (HP:0000926)1.74591249
125Abnormality of macrophages (HP:0004311)1.74384385
126Abnormality of the acetabulum (HP:0003170)1.74089000
127Mild short stature (HP:0003502)1.74033806
128Deformed sella turcica (HP:0002681)1.73790126
129Abnormality of the pericardium (HP:0001697)1.71956223
130Generalized amyotrophy (HP:0003700)1.71871447
131Abnormal delivery (HP:0001787)1.71767931
132Tibial bowing (HP:0002982)1.71091581
133Radial bowing (HP:0002986)1.70996535
134Nephritis (HP:0000123)1.70384605
135Disproportionate tall stature (HP:0001519)1.69508133
136Neonatal short-limb short stature (HP:0008921)1.69495314
137Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69045044
138Scapular winging (HP:0003691)1.69005331
139Anomalous pulmonary venous return (HP:0010772)1.68665384
140Limited hip movement (HP:0008800)1.68138279
141Abnormality of dentin (HP:0010299)1.68073963
142Flat cornea (HP:0007720)1.67901101
143Bowel diverticulosis (HP:0005222)1.65896034
144Recurrent abscess formation (HP:0002722)1.65403477
145Elbow flexion contracture (HP:0002987)1.65275963
146Bone cyst (HP:0012062)1.65232265
147Muscle hypertrophy of the lower extremities (HP:0008968)1.64979271
148Segmental peripheral demyelination/remyelination (HP:0003481)1.64307371
149Venous abnormality (HP:0002624)1.64305687
150Abnormality of the astrocytes (HP:0100707)1.64190111
151Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63834577
152Bruising susceptibility (HP:0000978)1.62989558
153Ovoid vertebral bodies (HP:0003300)1.62421990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.22908058
2EPHA33.51770312
3MATK3.50571352
4TGFBR23.48386261
5EPHB13.41693811
6MYLK3.31857463
7FER2.86275020
8RIPK12.67880158
9PDGFRA2.62862922
10EPHA22.57439985
11AKT32.54968060
12SIK12.40145784
13TRIB32.36933938
14EPHB22.30066735
15TYK22.12468624
16DMPK1.93990921
17ERN11.88031629
18BLK1.76948209
19FGFR41.73998204
20TIE11.73338433
21PKN21.68031110
22BMX1.65763206
23LATS11.62928513
24STK381.61460016
25NME21.60672858
26MAP2K31.58302469
27PIK3CA1.51418989
28NLK1.49211819
29PTK61.48188179
30TRPM71.46879832
31LMTK21.46829084
32DDR21.46600823
33TAOK31.29225646
34ADRBK11.21662680
35PAK21.18053793
36IRAK41.15382225
37MAPK71.10685185
38PTK21.09182398
39CSK1.07440671
40LATS21.07155029
41TNK21.06149182
42GRK11.05543184
43PAK31.04758716
44GRK61.04227799
45FLT31.03528536
46MET1.01085763
47PDGFRB0.97099273
48RET0.96045876
49ERBB20.95838101
50SGK20.95108660
51RIPK40.94240133
52LRRK20.93961470
53HCK0.93345204
54INSRR0.89940217
55PAK40.89422146
56MARK20.88088266
57FGFR30.87010381
58CAMK1G0.86906353
59IRAK10.86740095
60MAP3K30.86631227
61PDK20.86478893
62PHKG10.86304678
63PHKG20.86304678
64ADRBK20.85902224
65IKBKE0.83872447
66JAK10.83828465
67CLK10.83285673
68SGK30.82674973
69JAK30.81969308
70PRPF4B0.80997859
71PRKD10.80818750
72ILK0.80756759
73ERBB30.80526213
74KIT0.80041164
75GRK70.76803601
76KDR0.76194649
77STK38L0.75678402
78ROCK10.72841855
79CAMK1D0.71459043
80MAP2K20.71212011
81DAPK30.70731672
82WNK10.69054346
83HIPK20.68580567
84NTRK10.67572419
85PTK2B0.67399949
86WNK40.67147274
87GSK3A0.66659833
88FGFR10.66562133
89MAP3K70.66222961
90PIK3CG0.66020609
91MST1R0.64971307
92MELK0.64730298
93PRKD20.63897056
94FES0.63136587
95ACVR1B0.61768375
96IKBKB0.61580687
97SGK4940.61300475
98SGK2230.61300475
99CDC42BPA0.59235144
100MAP3K20.59024510
101MAP3K130.58936284
102STK30.57300830
103MAP3K140.56549069
104TESK10.55893897
105NEK90.55008493
106MAPK120.54607606
107MAP3K10.53435835
108PDK30.53321976
109PDK40.53321976
110PRKCE0.52308146
111ROCK20.51253768
112GRK50.50667172
113TXK0.50270498
114BCKDK0.50089937
115PIM20.49849012
116PRKG20.47158625
117PDPK10.46756939
118OBSCN0.46341556
119MUSK0.46268371
120CAMK40.45105334
121BTK0.44300404
122STK240.43500759
123ABL10.43432842
124EGFR0.43415357
125MAPKAPK20.41836227
126DAPK20.41656757
127PRKCH0.41593598
128STK390.37903055
129MAP3K60.37031494
130MAP2K10.36198638
131FRK0.35145609
132MST40.35070125
133PRKAA20.34806174
134RPS6KC10.34647073
135RPS6KL10.34647073
136NME10.34477851
137SRC0.33131160
138JAK20.33100306
139ZAP700.31950832
140CHUK0.31864889
141RPS6KA20.31718196
142TGFBR10.31690048
143RPS6KA60.30229063

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.20746131
2Focal adhesion_Homo sapiens_hsa045102.99431892
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.80908825
4Dilated cardiomyopathy_Homo sapiens_hsa054142.72749019
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.67859938
6Amoebiasis_Homo sapiens_hsa051462.50725254
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.26259350
8Bladder cancer_Homo sapiens_hsa052192.18905886
9Small cell lung cancer_Homo sapiens_hsa052222.07144319
10Adherens junction_Homo sapiens_hsa045202.01647666
11Proteoglycans in cancer_Homo sapiens_hsa052052.00575240
12Viral myocarditis_Homo sapiens_hsa054161.85231694
13Protein digestion and absorption_Homo sapiens_hsa049741.80640618
14Toxoplasmosis_Homo sapiens_hsa051451.76219906
15TGF-beta signaling pathway_Homo sapiens_hsa043501.67245484
16Malaria_Homo sapiens_hsa051441.63877646
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56208403
18Pancreatic cancer_Homo sapiens_hsa052121.50391255
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45670980
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.41210842
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.32788211
22HIF-1 signaling pathway_Homo sapiens_hsa040661.31998852
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.26987703
24Pathways in cancer_Homo sapiens_hsa052001.25781705
25Ovarian steroidogenesis_Homo sapiens_hsa049131.21121300
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18171521
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18005366
28Chronic myeloid leukemia_Homo sapiens_hsa052201.12705510
29Rheumatoid arthritis_Homo sapiens_hsa053231.08270485
30African trypanosomiasis_Homo sapiens_hsa051431.07634480
31Hematopoietic cell lineage_Homo sapiens_hsa046401.06731198
32Renal cell carcinoma_Homo sapiens_hsa052111.06068028
33Insulin resistance_Homo sapiens_hsa049311.06033249
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.03268297
35Platelet activation_Homo sapiens_hsa046111.01780688
36Leishmaniasis_Homo sapiens_hsa051401.01085434
37Caffeine metabolism_Homo sapiens_hsa002320.99504748
38MicroRNAs in cancer_Homo sapiens_hsa052060.99257768
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98930858
40Endometrial cancer_Homo sapiens_hsa052130.98576272
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.98462729
42Prostate cancer_Homo sapiens_hsa052150.97727850
43Mineral absorption_Homo sapiens_hsa049780.97401297
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96016792
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95087057
46Complement and coagulation cascades_Homo sapiens_hsa046100.90921894
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.90861007
48Fatty acid biosynthesis_Homo sapiens_hsa000610.90621095
49TNF signaling pathway_Homo sapiens_hsa046680.89459123
50Arachidonic acid metabolism_Homo sapiens_hsa005900.89208838
51Hippo signaling pathway_Homo sapiens_hsa043900.88841141
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.88346314
53ABC transporters_Homo sapiens_hsa020100.87893235
54Tight junction_Homo sapiens_hsa045300.87840808
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87316772
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.87314806
57Measles_Homo sapiens_hsa051620.85880026
58Acute myeloid leukemia_Homo sapiens_hsa052210.85284801
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84366305
60Chemokine signaling pathway_Homo sapiens_hsa040620.83734261
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82851927
62Pertussis_Homo sapiens_hsa051330.80211733
63Rap1 signaling pathway_Homo sapiens_hsa040150.78478745
64Hepatitis C_Homo sapiens_hsa051600.77882196
65Influenza A_Homo sapiens_hsa051640.77415241
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77392824
67Notch signaling pathway_Homo sapiens_hsa043300.76282664
68Galactose metabolism_Homo sapiens_hsa000520.76193361
69Fatty acid degradation_Homo sapiens_hsa000710.75746675
70Osteoclast differentiation_Homo sapiens_hsa043800.75551664
71Phagosome_Homo sapiens_hsa041450.74682282
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74322870
73Graft-versus-host disease_Homo sapiens_hsa053320.73062836
74PPAR signaling pathway_Homo sapiens_hsa033200.73005961
75Choline metabolism in cancer_Homo sapiens_hsa052310.72867891
76Legionellosis_Homo sapiens_hsa051340.72492798
77Fatty acid metabolism_Homo sapiens_hsa012120.70715685
78Vibrio cholerae infection_Homo sapiens_hsa051100.70575283
79Dorso-ventral axis formation_Homo sapiens_hsa043200.70080935
80Salmonella infection_Homo sapiens_hsa051320.69943515
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67471239
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67005781
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66696955
84Renin secretion_Homo sapiens_hsa049240.65914021
85Lysosome_Homo sapiens_hsa041420.64625984
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63454140
87Estrogen signaling pathway_Homo sapiens_hsa049150.63267167
88Melanoma_Homo sapiens_hsa052180.62593053
89Collecting duct acid secretion_Homo sapiens_hsa049660.61632044
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61251741
91Circadian rhythm_Homo sapiens_hsa047100.60688487
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59408920
93Colorectal cancer_Homo sapiens_hsa052100.59177487
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58954036
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58185452
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57111772
97mTOR signaling pathway_Homo sapiens_hsa041500.57088882
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55886518
99Endocytosis_Homo sapiens_hsa041440.55239186
100Prolactin signaling pathway_Homo sapiens_hsa049170.54786746
101FoxO signaling pathway_Homo sapiens_hsa040680.54713985
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54493770
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54451379
104Insulin signaling pathway_Homo sapiens_hsa049100.54350951
105Apoptosis_Homo sapiens_hsa042100.54350669
106Starch and sucrose metabolism_Homo sapiens_hsa005000.54289388
107Ras signaling pathway_Homo sapiens_hsa040140.53022378
108Calcium signaling pathway_Homo sapiens_hsa040200.52802872
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52716807
110GnRH signaling pathway_Homo sapiens_hsa049120.52675730
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52337416
112Basal cell carcinoma_Homo sapiens_hsa052170.52333627
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52307489
114B cell receptor signaling pathway_Homo sapiens_hsa046620.51498106
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.50919445
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50494026
117Linoleic acid metabolism_Homo sapiens_hsa005910.50329648
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49471578
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49382682
120Glioma_Homo sapiens_hsa052140.48560366
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.47006718
122Phenylalanine metabolism_Homo sapiens_hsa003600.46185444
123Allograft rejection_Homo sapiens_hsa053300.46169762
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46062093
125Type II diabetes mellitus_Homo sapiens_hsa049300.46036634
126Other glycan degradation_Homo sapiens_hsa005110.45766759
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45448729
128Tuberculosis_Homo sapiens_hsa051520.45372376
129Non-small cell lung cancer_Homo sapiens_hsa052230.45114745
130Staphylococcus aureus infection_Homo sapiens_hsa051500.43902554
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43622708
132HTLV-I infection_Homo sapiens_hsa051660.42770042
133VEGF signaling pathway_Homo sapiens_hsa043700.42186159
134ErbB signaling pathway_Homo sapiens_hsa040120.41766049
135Gap junction_Homo sapiens_hsa045400.41122839
136Hepatitis B_Homo sapiens_hsa051610.41073872
137Salivary secretion_Homo sapiens_hsa049700.37308380
138MAPK signaling pathway_Homo sapiens_hsa040100.37264541
139Prion diseases_Homo sapiens_hsa050200.37065090
140Shigellosis_Homo sapiens_hsa051310.36664370
141Axon guidance_Homo sapiens_hsa043600.35586238
142Lysine degradation_Homo sapiens_hsa003100.35322448

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