CRK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of keratinocyte proliferation (GO:0010839)4.01526699
2cell adhesion mediated by integrin (GO:0033627)3.76525554
3protein localization to endosome (GO:0036010)3.52056510
4regulation of hippo signaling (GO:0035330)3.50332739
5hippo signaling (GO:0035329)3.44191143
6layer formation in cerebral cortex (GO:0021819)3.32173305
7insulin-like growth factor receptor signaling pathway (GO:0048009)3.23039255
8cytoskeletal anchoring at plasma membrane (GO:0007016)3.21899362
9regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.21283887
10negative regulation of chondrocyte differentiation (GO:0032331)3.14899065
11axon extension involved in axon guidance (GO:0048846)3.03663635
12neuron projection extension involved in neuron projection guidance (GO:1902284)3.03663635
13embryonic foregut morphogenesis (GO:0048617)3.03042168
14cytoplasmic mRNA processing body assembly (GO:0033962)3.02653368
15anterior/posterior axis specification, embryo (GO:0008595)3.01805301
16regulation of clathrin-mediated endocytosis (GO:2000369)2.98148285
17plasma membrane repair (GO:0001778)2.94366599
18regulation of keratinocyte proliferation (GO:0010837)2.83821188
19skin morphogenesis (GO:0043589)2.82238198
20establishment of nucleus localization (GO:0040023)2.77240838
21cell migration involved in sprouting angiogenesis (GO:0002042)2.74316211
22stress fiber assembly (GO:0043149)2.72940859
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.72050040
24notochord development (GO:0030903)2.71967984
25UDP-N-acetylglucosamine metabolic process (GO:0006047)2.71542145
26regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.69760094
27vascular endothelial growth factor signaling pathway (GO:0038084)2.68890469
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67080235
29membrane budding (GO:0006900)2.65495160
30ventricular cardiac muscle cell development (GO:0055015)2.65352417
31mitotic sister chromatid cohesion (GO:0007064)2.64264060
32polarized epithelial cell differentiation (GO:0030859)2.62580160
33glial cell proliferation (GO:0014009)2.59888145
34apoptotic cell clearance (GO:0043277)2.55891968
35negative regulation of vascular permeability (GO:0043116)2.55777492
36desmosome organization (GO:0002934)2.53538467
37collagen fibril organization (GO:0030199)2.52404629
38adherens junction assembly (GO:0034333)2.47668918
39protein localization to cell surface (GO:0034394)2.47076549
40midgut development (GO:0007494)2.46974567
41artery development (GO:0060840)2.46594612
42regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46192345
43hemidesmosome assembly (GO:0031581)2.45954325
44retina vasculature morphogenesis in camera-type eye (GO:0061299)2.44880988
45axon extension (GO:0048675)2.44864327
46negative regulation of stem cell proliferation (GO:2000647)2.43584277
47protein heterotrimerization (GO:0070208)2.41637088
48chondrocyte proliferation (GO:0035988)2.41510346
49lymph vessel development (GO:0001945)2.41394933
50mitotic metaphase plate congression (GO:0007080)2.41374698
51lung vasculature development (GO:0060426)2.39315393
52cellular protein complex localization (GO:0034629)2.39138709
53gastrulation with mouth forming second (GO:0001702)2.38888579
54endothelial cell morphogenesis (GO:0001886)2.37786463
55semaphorin-plexin signaling pathway (GO:0071526)2.37601203
56chondrocyte development (GO:0002063)2.36257899
57ganglion development (GO:0061548)2.36078945
58paraxial mesoderm development (GO:0048339)2.35606315
59endodermal cell differentiation (GO:0035987)2.31341622
60negative regulation of catenin import into nucleus (GO:0035414)2.30769902
61regulation of tight junction assembly (GO:2000810)2.30673100
62dendrite morphogenesis (GO:0048813)2.28653400
63renal filtration (GO:0097205)2.27854172
64wound healing, spreading of epidermal cells (GO:0035313)2.27639998
65negative regulation of axon extension involved in axon guidance (GO:0048843)2.27432134
66metaphase plate congression (GO:0051310)2.26042089
67negative regulation of cartilage development (GO:0061037)2.25708346
68endocardial cushion development (GO:0003197)2.24386782
69blood vessel endothelial cell migration (GO:0043534)2.23919812
70platelet-derived growth factor receptor signaling pathway (GO:0048008)2.22454469
71regulation of axon extension involved in axon guidance (GO:0048841)2.21200469
72cell-substrate junction assembly (GO:0007044)2.20808740
73lysine catabolic process (GO:0006554)2.20330798
74lysine metabolic process (GO:0006553)2.20330798
75mesenchymal-epithelial cell signaling (GO:0060638)2.19869011
76cardiac epithelial to mesenchymal transition (GO:0060317)2.19317631
77growth hormone receptor signaling pathway (GO:0060396)2.19187938
78regulation of integrin-mediated signaling pathway (GO:2001044)2.19023038
79basement membrane organization (GO:0071711)2.18404756
80nucleotide-sugar biosynthetic process (GO:0009226)2.18150683
81negative regulation of fatty acid transport (GO:2000192)2.17986509
82cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.17906768
83mitotic cytokinesis (GO:0000281)2.17381678
84heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.15921659
85cytoskeleton-dependent cytokinesis (GO:0061640)2.14755185
86regulation of meiosis I (GO:0060631)2.14688490
87vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.14489900
88gap junction assembly (GO:0016264)2.14487381
89kidney mesenchyme development (GO:0072074)2.13809483
90mesodermal cell differentiation (GO:0048333)2.12960985
91epithelial cell-cell adhesion (GO:0090136)2.12775531
92patterning of blood vessels (GO:0001569)2.12545769
93regulation of axon guidance (GO:1902667)2.12473083
94negative regulation of cardiac muscle tissue development (GO:0055026)2.11815239
95dendritic spine morphogenesis (GO:0060997)2.11581151
96regulation of transforming growth factor beta2 production (GO:0032909)2.11339626
97renal system development (GO:0072001)2.09162992
98positive regulation of adherens junction organization (GO:1903393)2.09074721
99NLS-bearing protein import into nucleus (GO:0006607)2.08714295
100neuron projection extension (GO:1990138)2.08331597
101apical protein localization (GO:0045176)2.08138641
102adherens junction organization (GO:0034332)2.07245946
103positive regulation of protein autophosphorylation (GO:0031954)2.07000964
104ectoderm development (GO:0007398)2.06860826
105positive regulation of axon extension (GO:0045773)2.06767047
106substrate adhesion-dependent cell spreading (GO:0034446)2.06302231
107clathrin coat assembly (GO:0048268)2.06251918
108branching involved in salivary gland morphogenesis (GO:0060445)2.05781743
109glucocorticoid receptor signaling pathway (GO:0042921)2.04459038
110dorsal/ventral axis specification (GO:0009950)2.04286657
111substrate-dependent cell migration (GO:0006929)2.04077234
112organ formation (GO:0048645)2.03040289
113dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.02727756
114activin receptor signaling pathway (GO:0032924)2.02369801
115protein targeting to plasma membrane (GO:0072661)2.02005910
116smooth muscle tissue development (GO:0048745)2.01710498
117neural crest cell development (GO:0014032)2.01604702
118actin filament bundle assembly (GO:0051017)2.01588031
119actin filament bundle organization (GO:0061572)2.01588031
120axonal fasciculation (GO:0007413)2.01509741
121positive regulation of cell junction assembly (GO:1901890)2.01095691
122positive regulation of focal adhesion assembly (GO:0051894)2.01095691
123sequestering of extracellular ligand from receptor (GO:0035581)2.01053672
124cardiac right ventricle morphogenesis (GO:0003215)2.00984455
125negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.00574662
126establishment of apical/basal cell polarity (GO:0035089)2.00232153
127lung epithelium development (GO:0060428)2.00230828
128regulation of chondrocyte differentiation (GO:0032330)1.99789299
129peptidyl-lysine dimethylation (GO:0018027)1.98571862
130regulation of plasminogen activation (GO:0010755)1.98564452
131negative regulation of sodium ion transport (GO:0010766)1.98243199
132regulation of catenin import into nucleus (GO:0035412)1.98211131
133epithelial cell differentiation involved in prostate gland development (GO:0060742)1.97919149
134mitotic chromosome condensation (GO:0007076)1.97840052
135intestinal epithelial cell development (GO:0060576)1.97811664
136cellular response to growth hormone stimulus (GO:0071378)1.97528131
137positive regulation of nitric-oxide synthase activity (GO:0051000)1.97446342
138negative regulation of protein localization to cell surface (GO:2000009)1.97386187
139protein heterotetramerization (GO:0051290)1.97332546
140establishment of monopolar cell polarity (GO:0061162)1.97242405
141establishment or maintenance of monopolar cell polarity (GO:0061339)1.97242405
142lens morphogenesis in camera-type eye (GO:0002089)1.97124287
143lymphangiogenesis (GO:0001946)1.97096146
144corticosteroid receptor signaling pathway (GO:0031958)1.96808867
145establishment of epithelial cell polarity (GO:0090162)1.96646429
146cell fate commitment involved in formation of primary germ layer (GO:0060795)1.96214871
147regulation of nephron tubule epithelial cell differentiation (GO:0072182)1.94676839
148negative chemotaxis (GO:0050919)1.94570496
149regulation of cardioblast differentiation (GO:0051890)1.93985150
150negative regulation of BMP signaling pathway (GO:0030514)1.93690154
151cell migration involved in gastrulation (GO:0042074)1.93409747
152positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)1.93244708
153metanephric mesenchyme development (GO:0072075)1.92814232
154protein complex localization (GO:0031503)1.92754082
155negative regulation of fibroblast apoptotic process (GO:2000270)1.92249380
156ER overload response (GO:0006983)1.92047579
157membrane assembly (GO:0071709)1.91703490
158barbed-end actin filament capping (GO:0051016)1.91661280
159positive regulation of glycogen biosynthetic process (GO:0045725)1.91625808
160regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.90832617
161cell-substrate adherens junction assembly (GO:0007045)1.90415734
162focal adhesion assembly (GO:0048041)1.90415734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76179515
2AR_21909140_ChIP-Seq_LNCAP_Human2.74531011
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.68118851
4CLOCK_20551151_ChIP-Seq_293T_Human2.38099421
5TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.23254630
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.15686902
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15095183
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02916140
9ZNF217_24962896_ChIP-Seq_MCF-7_Human2.02802277
10* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00224526
11FOXM1_23109430_ChIP-Seq_U2OS_Human1.99358387
12SALL1_21062744_ChIP-ChIP_HESCs_Human1.98941964
13SMAD_19615063_ChIP-ChIP_OVARY_Human1.87576524
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87072146
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.86989423
16TP63_17297297_ChIP-ChIP_HaCaT_Human1.85304768
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83048679
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.80763809
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.79766317
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75936637
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74548518
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70472173
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63591403
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63162729
25TP53_16413492_ChIP-PET_HCT116_Human1.62569127
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60528225
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.59845877
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58176758
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57683071
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57683071
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54417480
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54260701
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54030125
34ZNF263_19887448_ChIP-Seq_K562_Human1.53114343
35CJUN_26792858_Chip-Seq_BT549_Human1.51543045
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50742561
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50742561
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.50101725
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49917294
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42977817
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38619407
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33409393
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32730784
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32005003
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30878048
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30654201
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30308182
48EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29764025
49AHR_22903824_ChIP-Seq_MCF-7_Human1.29121479
50DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28813653
51STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28485134
52KDM2B_26808549_Chip-Seq_K562_Human1.28453673
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.27159164
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27078814
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26854847
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.26668045
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26095533
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25657204
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.24212627
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22941208
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22750340
62BRD4_25478319_ChIP-Seq_HGPS_Human1.21627989
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.21382882
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.21374839
65* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20620761
66RXR_22108803_ChIP-Seq_LS180_Human1.20460421
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19777403
68P300_19829295_ChIP-Seq_ESCs_Human1.19541200
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.19473551
70TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18608881
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18512805
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18379893
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18343710
74TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18282280
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18126236
76* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18119701
77SOX2_20726797_ChIP-Seq_SW620_Human1.17358599
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17249271
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17085874
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16403828
81* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15065053
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14628859
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13110380
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13042937
85TP53_18474530_ChIP-ChIP_U2OS_Human1.12530647
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12078513
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12078513
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11859976
89AR_21572438_ChIP-Seq_LNCaP_Human1.11679467
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11013118
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10419230
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09749531
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.09580053
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09280972
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08254812
96SOX17_20123909_ChIP-Seq_XEN_Mouse1.07956706
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.07954066
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.07672172
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07058698
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06690327
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04831042
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.04757221
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04636612
104E2F7_22180533_ChIP-Seq_HELA_Human1.04635080
105* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04291892
106RXR_22158963_ChIP-Seq_LIVER_Mouse1.03845566
107MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03526582
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03184901
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02968727
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02848651
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02848651
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02848651
113* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02684558
114* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02354020
115TP63_23658742_ChIP-Seq_EP156T_Human1.01706346
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01227844
117BCAT_22108803_ChIP-Seq_LS180_Human1.01216418
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.01102902
119JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00445848
120KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00104386
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.99771007
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99207908
123GBX2_23144817_ChIP-Seq_PC3_Human0.98834221
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98804212
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98780768
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98680148
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98418306
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98397836
129* GATA2_21666600_ChIP-Seq_HMVEC_Human0.98114005
130KDM2B_26808549_Chip-Seq_JURKAT_Human0.97891463
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97235716
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96899938
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.96650554
134SMAD4_21799915_ChIP-Seq_A2780_Human0.96357071
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96326728
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95281739
137FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94814314
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94733562
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94252620
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94173323
141* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93685085
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92657462
143TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89999105
144FUS_26573619_Chip-Seq_HEK293_Human0.88919954
145YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88334123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.43695990
2MP0010234_abnormal_vibrissa_follicle4.41894550
3MP0008438_abnormal_cutaneous_collagen3.24187090
4MP0003950_abnormal_plasma_membrane3.09543133
5MP0003941_abnormal_skin_development3.08106725
6MP0000537_abnormal_urethra_morphology3.01573271
7MP0004272_abnormal_basement_membrane2.96653403
8MP0005623_abnormal_meninges_morphology2.63154196
9MP0005275_abnormal_skin_tensile2.31511885
10MP0009053_abnormal_anal_canal2.26160524
11MP0010368_abnormal_lymphatic_system2.15466804
12MP0005187_abnormal_penis_morphology1.91464287
13MP0003091_abnormal_cell_migration1.90580456
14MP0010678_abnormal_skin_adnexa1.86741422
15MP0005503_abnormal_tendon_morphology1.83972441
16MP0004233_abnormal_muscle_weight1.80804161
17MP0010030_abnormal_orbit_morphology1.79449237
18MP0009384_cardiac_valve_regurgitation1.75631182
19MP0010352_gastrointestinal_tract_polyps1.75468902
20MP0000762_abnormal_tongue_morphology1.74191818
21MP0000733_abnormal_muscle_development1.68215861
22MP0003566_abnormal_cell_adhesion1.67860309
23MP0003890_abnormal_embryonic-extraembry1.67314350
24MP0004859_abnormal_synaptic_plasticity1.64035759
25MP0001958_emphysema1.59997106
26MP0003283_abnormal_digestive_organ1.57378587
27MP0002877_abnormal_melanocyte_morpholog1.54240197
28MP0006054_spinal_hemorrhage1.52638126
29MP0003252_abnormal_bile_duct1.52313241
30MP0005409_darkened_coat_color1.49935526
31MP0001879_abnormal_lymphatic_vessel1.49631799
32MP0003385_abnormal_body_wall1.49365683
33MP0003115_abnormal_respiratory_system1.45505631
34MP0005248_abnormal_Harderian_gland1.43870803
35MP0009780_abnormal_chondrocyte_physiolo1.42689945
36MP0004185_abnormal_adipocyte_glucose1.40597438
37MP0002896_abnormal_bone_mineralization1.39586765
38MP0003300_gastrointestinal_ulcer1.37731296
39MP0004858_abnormal_nervous_system1.37230423
40MP0004084_abnormal_cardiac_muscle1.36553989
41MP0005167_abnormal_blood-brain_barrier1.32509526
42MP0001849_ear_inflammation1.31046901
43MP0003937_abnormal_limbs/digits/tail_de1.30987945
44MP0004270_analgesia1.30176277
45MP0002282_abnormal_trachea_morphology1.28787530
46MP0000467_abnormal_esophagus_morphology1.28469598
47MP0006138_congestive_heart_failure1.27293955
48MP0000534_abnormal_ureter_morphology1.26597001
49MP0000579_abnormal_nail_morphology1.26366142
50MP0005360_urolithiasis1.22205283
51MP0001299_abnormal_eye_distance/1.20904283
52MP0003279_aneurysm1.20861154
53MP0005076_abnormal_cell_differentiation1.09963717
54* MP0000767_abnormal_smooth_muscle1.09799818
55MP0000428_abnormal_craniofacial_morphol1.09146478
56MP0001915_intracranial_hemorrhage1.08965684
57* MP0002233_abnormal_nose_morphology1.06770541
58MP0000569_abnormal_digit_pigmentation1.06125459
59MP0002234_abnormal_pharynx_morphology1.05824064
60MP0004130_abnormal_muscle_cell1.05789771
61MP0000647_abnormal_sebaceous_gland1.05488654
62MP0004264_abnormal_extraembryonic_tissu1.04516352
63MP0003868_abnormal_feces_composition1.04224225
64MP0009250_abnormal_appendicular_skeleto1.03892451
65MP0004484_altered_response_of1.02580888
66MP0003942_abnormal_urinary_system1.02163340
67MP0010630_abnormal_cardiac_muscle1.01227224
68MP0002925_abnormal_cardiovascular_devel0.99022533
69MP0003329_amyloid_beta_deposits0.98927495
70* MP0003935_abnormal_craniofacial_develop0.98635658
71MP0009278_abnormal_bone_marrow0.98195916
72MP0005197_abnormal_uvea_morphology0.97698781
73MP0005023_abnormal_wound_healing0.97097170
74* MP0005595_abnormal_vascular_smooth0.96612147
75MP0002837_dystrophic_cardiac_calcinosis0.96445466
76MP0002796_impaired_skin_barrier0.96433580
77MP0000383_abnormal_hair_follicle0.95322013
78MP0000462_abnormal_digestive_system0.94596140
79MP0000516_abnormal_urinary_system0.94025189
80MP0005367_renal/urinary_system_phenotyp0.94025189
81MP0005508_abnormal_skeleton_morphology0.93608746
82* MP0003755_abnormal_palate_morphology0.93405340
83MP0008932_abnormal_embryonic_tissue0.92935785
84MP0001177_atelectasis0.92870068
85MP0002085_abnormal_embryonic_tissue0.92570377
86MP0005257_abnormal_intraocular_pressure0.92503967
87MP0004087_abnormal_muscle_fiber0.89912438
88MP0004957_abnormal_blastocyst_morpholog0.89138899
89MP0003693_abnormal_embryo_hatching0.88831724
90MP0000049_abnormal_middle_ear0.88329051
91MP0002938_white_spotting0.88190919
92MP0002092_abnormal_eye_morphology0.86856609
93MP0000013_abnormal_adipose_tissue0.86660248
94MP0000778_abnormal_nervous_system0.84868392
95MP0002972_abnormal_cardiac_muscle0.84662987
96MP0001293_anophthalmia0.83683485
97MP0003567_abnormal_fetal_cardiomyocyte0.83422639
98MP0005666_abnormal_adipose_tissue0.83219497
99MP0003119_abnormal_digestive_system0.83182452
100MP0002295_abnormal_pulmonary_circulatio0.83082058
101MP0000427_abnormal_hair_cycle0.82754047
102* MP0001614_abnormal_blood_vessel0.82683477
103MP0002084_abnormal_developmental_patter0.82605814
104MP0002108_abnormal_muscle_morphology0.82456659
105MP0005620_abnormal_muscle_contractility0.82399445
106MP0008961_abnormal_basal_metabolism0.82300658
107MP0003453_abnormal_keratinocyte_physiol0.81361923
108MP0002177_abnormal_outer_ear0.81287791
109MP0000751_myopathy0.81275447
110MP0002086_abnormal_extraembryonic_tissu0.81192732
111MP0001243_abnormal_dermal_layer0.80474004
112MP0003045_fibrosis0.80308560
113MP0003221_abnormal_cardiomyocyte_apopto0.79508045
114MP0002932_abnormal_joint_morphology0.79250664
115* MP0002128_abnormal_blood_circulation0.78740210
116MP0005501_abnormal_skin_physiology0.78695618
117MP0003123_paternal_imprinting0.78533862
118MP0002697_abnormal_eye_size0.78400598
119MP0002098_abnormal_vibrissa_morphology0.77980328
120MP0004197_abnormal_fetal_growth/weight/0.77143204
121MP0001672_abnormal_embryogenesis/_devel0.76693061
122MP0005380_embryogenesis_phenotype0.76693061
123MP0001216_abnormal_epidermal_layer0.76607054
124MP0002168_other_aberrant_phenotype0.76413511
125MP0002111_abnormal_tail_morphology0.75305469
126MP0002060_abnormal_skin_morphology0.74941914
127MP0005171_absent_coat_pigmentation0.74121343
128MP0010771_integument_phenotype0.74097452
129MP0005085_abnormal_gallbladder_physiolo0.73662192
130MP0001542_abnormal_bone_strength0.73531926
131MP0001286_abnormal_eye_development0.73229140
132MP0000003_abnormal_adipose_tissue0.73060823
133MP0003122_maternal_imprinting0.72845817
134MP0000432_abnormal_head_morphology0.72343259
135MP0005375_adipose_tissue_phenotype0.72233350
136MP0002116_abnormal_craniofacial_bone0.70806178
137MP0000377_abnormal_hair_follicle0.69312096
138MP0002254_reproductive_system_inflammat0.69060413
139MP0002088_abnormal_embryonic_growth/wei0.68390610
140MP0003718_maternal_effect0.68304001

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.67206321
2Shallow orbits (HP:0000586)3.59066239
3Premature rupture of membranes (HP:0001788)3.22885235
4Soft skin (HP:0000977)2.99026176
5Cerebral aneurysm (HP:0004944)2.86451345
6Aortic aneurysm (HP:0004942)2.86435136
7Subacute progressive viral hepatitis (HP:0006572)2.84976144
8Insidious onset (HP:0003587)2.78324597
9Termporal pattern (HP:0011008)2.78324597
10Mitral valve prolapse (HP:0001634)2.73816342
11Ankle contracture (HP:0006466)2.66439954
12Lymphangioma (HP:0100764)2.65759422
13Aortic dissection (HP:0002647)2.65362869
14Follicular hyperkeratosis (HP:0007502)2.64527983
15Broad metatarsal (HP:0001783)2.64317293
16Buphthalmos (HP:0000557)2.62105372
17Vascular tortuosity (HP:0004948)2.54309698
18Arterial tortuosity (HP:0005116)2.54045019
19Atrophic scars (HP:0001075)2.50807067
20Hematochezia (HP:0002573)2.47598039
21Neonatal short-limb short stature (HP:0008921)2.46879734
22Peritonitis (HP:0002586)2.44171160
23Deep venous thrombosis (HP:0002625)2.40561855
24Enlarged penis (HP:0000040)2.37083074
25Asymmetry of the thorax (HP:0001555)2.28198004
26Cardiovascular calcification (HP:0011915)2.24848106
27Aneurysm (HP:0002617)2.23558685
28Genu recurvatum (HP:0002816)2.23314956
29Right ventricular cardiomyopathy (HP:0011663)2.22100916
30Long toe (HP:0010511)2.19182206
31Scapular winging (HP:0003691)2.17299803
32Ankyloglossia (HP:0010296)2.17063554
33Short 4th metacarpal (HP:0010044)2.14449654
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14449654
35Dilatation of the ascending aorta (HP:0005111)2.13296641
36Bladder diverticulum (HP:0000015)2.11406938
37Overgrowth (HP:0001548)2.07247273
38Short nail (HP:0001799)2.06165599
39Deviation of the hallux (HP:0010051)2.03471106
40Focal segmental glomerulosclerosis (HP:0000097)2.00985758
41Microglossia (HP:0000171)2.00675589
42Bronchomalacia (HP:0002780)2.00128632
43Hallux valgus (HP:0001822)1.98150294
44Pterygium (HP:0001059)1.94510031
45Camptodactyly of toe (HP:0001836)1.94240843
46Abnormality of the 4th metacarpal (HP:0010012)1.93373986
47Abnormality of dentin (HP:0010299)1.92119811
48Striae distensae (HP:0001065)1.90922995
49Macroorchidism (HP:0000053)1.89608309
50Increased connective tissue (HP:0009025)1.89104611
51Natal tooth (HP:0000695)1.88895297
52Wormian bones (HP:0002645)1.88174418
53Hyperextensible skin (HP:0000974)1.87857770
54Cervical subluxation (HP:0003308)1.87658235
55Turricephaly (HP:0000262)1.87066550
56Exostoses (HP:0100777)1.86806891
57Coronal craniosynostosis (HP:0004440)1.85242965
58Achilles tendon contracture (HP:0001771)1.82276187
59Abnormality of the Achilles tendon (HP:0005109)1.81977257
60Abnormality of oral frenula (HP:0000190)1.80635105
61Venous abnormality (HP:0002624)1.79992590
62Back pain (HP:0003418)1.79877205
63Vertebral arch anomaly (HP:0008438)1.79860156
64Knee flexion contracture (HP:0006380)1.79347917
65Abnormality of the umbilical cord (HP:0010881)1.79319526
66Spinal rigidity (HP:0003306)1.78393634
67Vascular calcification (HP:0004934)1.78050586
68Absent frontal sinuses (HP:0002688)1.77917539
69Cerebral inclusion bodies (HP:0100314)1.77316688
70Abnormal umbilical cord blood vessels (HP:0011403)1.77098169
71Single umbilical artery (HP:0001195)1.77098169
72Abnormality of the fetal cardiovascular system (HP:0010948)1.77098169
73Wrist flexion contracture (HP:0001239)1.76231312
74Protruding ear (HP:0000411)1.76176322
75Bowel diverticulosis (HP:0005222)1.75556566
76Blue sclerae (HP:0000592)1.74721460
77Upper limb amyotrophy (HP:0009129)1.72353762
78Distal upper limb amyotrophy (HP:0007149)1.72353762
79Visceral angiomatosis (HP:0100761)1.71315021
80Lower limb asymmetry (HP:0100559)1.70198804
81Ulnar bowing (HP:0003031)1.69986355
82Pulmonic stenosis (HP:0001642)1.69593795
83Hemangiomatosis (HP:0007461)1.69547462
84Esophageal varix (HP:0002040)1.69171447
85Thin bony cortex (HP:0002753)1.69079337
86Glomerulosclerosis (HP:0000096)1.68279220
87Venous insufficiency (HP:0005293)1.67948378
88Fibroma (HP:0010614)1.66829864
89Short hallux (HP:0010109)1.66502609
90Hepatoblastoma (HP:0002884)1.65482007
91Fibrous tissue neoplasm (HP:0012316)1.65299669
92Spastic diplegia (HP:0001264)1.64816758
93Aortic valve stenosis (HP:0001650)1.64590516
94Vertebral clefting (HP:0008428)1.64203846
95Abnormality of carpal bone ossification (HP:0006257)1.64103104
96Abnormal delivery (HP:0001787)1.63678422
97Mitral stenosis (HP:0001718)1.63631242
98Limb-girdle muscle weakness (HP:0003325)1.63073294
99Delayed gross motor development (HP:0002194)1.62505944
100Abnormality of the phalanges of the hallux (HP:0010057)1.62128522
101Osteolytic defects of the phalanges of the hand (HP:0009771)1.62027273
102Osteolytic defects of the hand bones (HP:0009699)1.62027273
103Type 1 muscle fiber predominance (HP:0003803)1.61070437
104Hyporeflexia of lower limbs (HP:0002600)1.59832910
105Fragile skin (HP:0001030)1.58206620
106Congenital glaucoma (HP:0001087)1.58161296
107Syringomyelia (HP:0003396)1.57499752
108Spinal cord lesions (HP:0100561)1.57499752
109Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.56989350
110Vertebral hypoplasia (HP:0008417)1.56989350
111Action tremor (HP:0002345)1.56743313
112Infantile muscular hypotonia (HP:0008947)1.56317151
113Tetraparesis (HP:0002273)1.55101373
114Intrahepatic cholestasis (HP:0001406)1.55086216
115Limited hip movement (HP:0008800)1.54714327
116Tibial bowing (HP:0002982)1.52580636
117Aplasia/Hypoplasia of the hallux (HP:0008362)1.52557812
118Abnormal biliary tract morphology (HP:0012440)1.51820213
119Bilateral sensorineural hearing impairment (HP:0008619)1.51751957
120Difficulty running (HP:0009046)1.51057337
121Increased variability in muscle fiber diameter (HP:0003557)1.51018170
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.50930812
123Papillary thyroid carcinoma (HP:0002895)1.50858866
124Hydroureter (HP:0000072)1.50509377
125Arnold-Chiari malformation (HP:0002308)1.50363539
126Cubitus valgus (HP:0002967)1.50231365
127Wide anterior fontanel (HP:0000260)1.50022084
128Abnormality of the 2nd finger (HP:0004100)1.49950995
129Renal duplication (HP:0000075)1.49654677
130Micronodular cirrhosis (HP:0001413)1.49617849
131Mitral regurgitation (HP:0001653)1.48537540
132Hypoplastic toenails (HP:0001800)1.47375679
133Radial bowing (HP:0002986)1.47308063
134Milia (HP:0001056)1.47201942
135Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.46786553
136Abnormality of the acetabulum (HP:0003170)1.46746955
137Abnormalities of placenta or umbilical cord (HP:0001194)1.46274251
138Fragile nails (HP:0001808)1.46098068
139Chorioretinal atrophy (HP:0000533)1.45855064
140Elfin facies (HP:0004428)1.45613243
141Increased number of teeth (HP:0011069)1.45131147
142Hypoplastic ischia (HP:0003175)1.45115635
143Tarsal synostosis (HP:0008368)1.44839649
144Broad thumb (HP:0011304)1.44751783
145Hypoalphalipoproteinemia (HP:0003233)1.44571327
146Abnormality of the astrocytes (HP:0100707)1.44255202
147Astrocytoma (HP:0009592)1.44255202
148Volvulus (HP:0002580)1.43793660
149Increased nuchal translucency (HP:0010880)1.43034073
150Spinal cord compression (HP:0002176)1.42792657
151Elbow flexion contracture (HP:0002987)1.42769482
152Popliteal pterygium (HP:0009756)1.41971409
153Fused cervical vertebrae (HP:0002949)1.40985200
154Breech presentation (HP:0001623)1.40935617
155Missing ribs (HP:0000921)1.39864009
156Reduced subcutaneous adipose tissue (HP:0003758)1.38881005
157Gastrointestinal carcinoma (HP:0002672)1.38498500
158Malignant gastrointestinal tract tumors (HP:0006749)1.38498500
159Leiomyosarcoma (HP:0100243)1.38063161
160Uterine leiomyosarcoma (HP:0002891)1.38063161
161Hypolipoproteinemia (HP:0010981)1.36642823
162Joint laxity (HP:0001388)1.36471821
163Preaxial foot polydactyly (HP:0001841)1.35979834
164Conjugated hyperbilirubinemia (HP:0002908)1.35603206
165Cutaneous finger syndactyly (HP:0010554)1.34756899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.32755619
2LATS23.36285668
3TRIB33.30711598
4PKN23.19290819
5PNCK3.02184319
6PBK2.66390782
7BRSK22.31418125
8CASK2.31286507
9KSR22.31065408
10RIPK12.28619517
11PDGFRA2.26206594
12FRK2.18830156
13MAP3K92.13620622
14TSSK62.07794809
15TTN2.02798173
16WEE12.00299420
17DDR21.99834572
18KSR11.92508571
19EPHB21.86483811
20STK38L1.76425733
21PAK61.73224710
22EIF2AK31.70577562
23STK241.62686054
24FER1.58706128
25MAP3K41.54652521
26RET1.54387241
27ACVR1B1.54102648
28PTK61.53284990
29MAP3K61.52196551
30BUB11.51899322
31NTRK11.50190629
32TTK1.47075008
33PAK31.42422571
34MAP3K121.40244274
35PTK21.38534291
36CDK61.38286631
37MAP2K41.33463503
38TIE11.30594033
39TRIM281.27582543
40STK31.24386864
41FGFR21.22421373
42PAK21.22091561
43STK381.20721263
44DMPK1.20242962
45ERBB41.19330597
46TYRO31.18368625
47MET1.18273932
48MAP3K21.17642997
49SCYL21.17621718
50MYLK1.12765176
51MINK11.11972448
52PDGFRB1.11102597
53ERN11.06979488
54CAMK1G1.05995542
55CAMKK11.05691354
56CAMK1D1.03497593
57PLK31.02859025
58EPHA41.02726957
59TGFBR21.00962045
60TNIK0.99779166
61MAP3K100.99573788
62BMPR1B0.98653175
63PRKD30.97024436
64AKT30.95351583
65BCR0.95041289
66BRSK10.94416620
67TAF10.92843404
68PLK20.90487193
69SIK10.89850659
70MKNK20.87035866
71LRRK20.83815906
72LMTK20.83754240
73IRAK30.82537077
74MAP2K10.81314318
75PLK10.79089703
76MELK0.77071536
77FGFR10.74932992
78TAOK10.74559387
79ERBB30.73955457
80CSNK1A1L0.73938434
81CSNK1G20.73498095
82WNK40.72047352
83PAK40.72020067
84SRPK10.70466489
85MARK10.69662422
86NEK10.68630967
87MUSK0.68208553
88PTK2B0.67403702
89GSK3A0.67189890
90MOS0.66531457
91BRAF0.65228681
92MST1R0.64039846
93EIF2AK10.63872472
94BMX0.62710472
95PRKCE0.62182408
96NTRK30.61189323
97TGFBR10.60087648
98NEK90.58854618
99RIPK40.57975324
100ERBB20.57174116
101ALK0.56313822
102MAP3K50.55921624
103EEF2K0.55593993
104RAF10.55375114
105CDK90.52761619
106WNK30.52668225
107CDK120.52233271
108PRKCH0.52158441
109ILK0.51916149
110ROCK10.50805112
111EPHA20.50686002
112MAP3K130.49507205
113MTOR0.49106650
114NEK20.48827060
115PRKCI0.48726553
116WNK10.48265374
117PDK20.48236643
118MST40.47696181
119STK390.47445101
120CHEK20.45846811
121* ABL20.45846308
122SGK30.44609164
123PRKD10.44237447
124CSNK1G10.43807448
125MAP3K80.43723705
126PKN10.43392134
127EIF2AK20.43096677
128EPHB10.43044388
129PDPK10.42860724
130LIMK10.40858531
131MAP2K30.40658590
132STK110.40654862
133ROCK20.40055401
134CDK80.39407252
135MAP3K30.39183257
136MAPKAPK30.39082500
137PRKG20.38839530
138DAPK20.38183017
139CDK50.37812788
140INSR0.36944131
141CDK140.35367081
142FGR0.35174573
143PHKG10.34869540
144PHKG20.34869540
145CAMK2D0.34230590
146YES10.33970228
147NEK60.33697875
148CLK10.33252592
149CSNK1E0.31899989
150ADRBK10.31506715

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.71328930
2Steroid biosynthesis_Homo sapiens_hsa001001.92169739
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91338755
4ECM-receptor interaction_Homo sapiens_hsa045121.80615383
5* Focal adhesion_Homo sapiens_hsa045101.70500140
6Adherens junction_Homo sapiens_hsa045201.65394221
7Vitamin B6 metabolism_Homo sapiens_hsa007501.64366922
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54209956
9Sulfur metabolism_Homo sapiens_hsa009201.46895304
10Proteoglycans in cancer_Homo sapiens_hsa052051.42725411
11Dorso-ventral axis formation_Homo sapiens_hsa043201.40897423
12p53 signaling pathway_Homo sapiens_hsa041151.38896972
13Glioma_Homo sapiens_hsa052141.38857241
14Hippo signaling pathway_Homo sapiens_hsa043901.36915463
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34509313
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26980807
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26909406
18Selenocompound metabolism_Homo sapiens_hsa004501.25473332
19Tight junction_Homo sapiens_hsa045301.25451171
20Axon guidance_Homo sapiens_hsa043601.22491082
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22294453
22* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20192686
23Amoebiasis_Homo sapiens_hsa051461.19587263
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18622210
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18272939
26Cell cycle_Homo sapiens_hsa041101.16197554
27Endometrial cancer_Homo sapiens_hsa052131.14862482
28GnRH signaling pathway_Homo sapiens_hsa049121.13756855
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13664800
30Estrogen signaling pathway_Homo sapiens_hsa049151.12124147
31Arginine biosynthesis_Homo sapiens_hsa002201.10936569
32Pancreatic cancer_Homo sapiens_hsa052121.10649523
33Dilated cardiomyopathy_Homo sapiens_hsa054141.09719773
34mTOR signaling pathway_Homo sapiens_hsa041501.09063929
35* Renal cell carcinoma_Homo sapiens_hsa052111.08889562
36Basal transcription factors_Homo sapiens_hsa030221.07473611
37* Chronic myeloid leukemia_Homo sapiens_hsa052201.07113624
38Long-term potentiation_Homo sapiens_hsa047201.06662836
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06626970
40Gap junction_Homo sapiens_hsa045401.06025311
41TGF-beta signaling pathway_Homo sapiens_hsa043501.05814291
42Bile secretion_Homo sapiens_hsa049761.05002611
43Small cell lung cancer_Homo sapiens_hsa052221.04246960
44Non-homologous end-joining_Homo sapiens_hsa034501.03910209
45VEGF signaling pathway_Homo sapiens_hsa043701.03365762
46Sphingolipid metabolism_Homo sapiens_hsa006001.03100883
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00777048
48Bladder cancer_Homo sapiens_hsa052191.00145491
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99987873
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99671863
51* MicroRNAs in cancer_Homo sapiens_hsa052060.96439938
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95895877
53Melanogenesis_Homo sapiens_hsa049160.95398063
54Long-term depression_Homo sapiens_hsa047300.95195868
55Gastric acid secretion_Homo sapiens_hsa049710.94231244
56Protein digestion and absorption_Homo sapiens_hsa049740.94211511
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93775824
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91694527
59* Rap1 signaling pathway_Homo sapiens_hsa040150.90806398
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88904158
61Insulin resistance_Homo sapiens_hsa049310.88272859
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87704913
63Platelet activation_Homo sapiens_hsa046110.87581333
64Propanoate metabolism_Homo sapiens_hsa006400.87531557
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86856566
66Colorectal cancer_Homo sapiens_hsa052100.85265093
67Caffeine metabolism_Homo sapiens_hsa002320.85006856
68Non-small cell lung cancer_Homo sapiens_hsa052230.84446141
69Prion diseases_Homo sapiens_hsa050200.84347862
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83932477
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83361819
72Thyroid hormone synthesis_Homo sapiens_hsa049180.83125707
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.82909700
74Oxytocin signaling pathway_Homo sapiens_hsa049210.82683041
75* ErbB signaling pathway_Homo sapiens_hsa040120.81456930
76Salivary secretion_Homo sapiens_hsa049700.80895340
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.80479966
78* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80008701
79Choline metabolism in cancer_Homo sapiens_hsa052310.79512056
80Dopaminergic synapse_Homo sapiens_hsa047280.79490552
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79473595
82Melanoma_Homo sapiens_hsa052180.79345224
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79245716
84Renin secretion_Homo sapiens_hsa049240.77710119
85Prostate cancer_Homo sapiens_hsa052150.76678391
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.76177274
87Basal cell carcinoma_Homo sapiens_hsa052170.76143196
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75529108
89* Neurotrophin signaling pathway_Homo sapiens_hsa047220.75089706
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74179154
91AMPK signaling pathway_Homo sapiens_hsa041520.74110838
92Fatty acid elongation_Homo sapiens_hsa000620.74056273
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72486983
94Lysine degradation_Homo sapiens_hsa003100.72295530
95Pyruvate metabolism_Homo sapiens_hsa006200.71781626
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.70182344
97Retinol metabolism_Homo sapiens_hsa008300.70136195
98Hedgehog signaling pathway_Homo sapiens_hsa043400.69608569
99PPAR signaling pathway_Homo sapiens_hsa033200.69509361
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69338816
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.68833281
102Complement and coagulation cascades_Homo sapiens_hsa046100.68525056
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68396157
104Fatty acid biosynthesis_Homo sapiens_hsa000610.67902695
105Cholinergic synapse_Homo sapiens_hsa047250.67763047
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67395098
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.67337885
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66846349
109Ras signaling pathway_Homo sapiens_hsa040140.66425917
110Wnt signaling pathway_Homo sapiens_hsa043100.66257257
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65981682
112Protein export_Homo sapiens_hsa030600.65856767
113Viral myocarditis_Homo sapiens_hsa054160.65274745
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.65254762
115Circadian entrainment_Homo sapiens_hsa047130.65090620
116Arginine and proline metabolism_Homo sapiens_hsa003300.64937890
117Thyroid cancer_Homo sapiens_hsa052160.64515191
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64143797
119Glucagon signaling pathway_Homo sapiens_hsa049220.63331280
120Type II diabetes mellitus_Homo sapiens_hsa049300.62797714
121Fatty acid degradation_Homo sapiens_hsa000710.62489470
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.62387023
123Butanoate metabolism_Homo sapiens_hsa006500.62227308
124One carbon pool by folate_Homo sapiens_hsa006700.61483644
125Circadian rhythm_Homo sapiens_hsa047100.61240979
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61146971
127FoxO signaling pathway_Homo sapiens_hsa040680.60916254
128Fatty acid metabolism_Homo sapiens_hsa012120.60494340
129* Insulin signaling pathway_Homo sapiens_hsa049100.60341330
130cAMP signaling pathway_Homo sapiens_hsa040240.59865645
131Mineral absorption_Homo sapiens_hsa049780.59222642
132Prolactin signaling pathway_Homo sapiens_hsa049170.58887389
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58085021
134Glutamatergic synapse_Homo sapiens_hsa047240.57685423
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54892686
136Oocyte meiosis_Homo sapiens_hsa041140.54144471
137Ovarian steroidogenesis_Homo sapiens_hsa049130.54039882
138* Pathways in cancer_Homo sapiens_hsa052000.52744899
139Vibrio cholerae infection_Homo sapiens_hsa051100.51714704
140N-Glycan biosynthesis_Homo sapiens_hsa005100.51622001
141RNA transport_Homo sapiens_hsa030130.51501702
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.49481157
143Vitamin digestion and absorption_Homo sapiens_hsa049770.47008421
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46548730
145Fat digestion and absorption_Homo sapiens_hsa049750.43740674
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43145536

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