CRKL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.10311284
2DNA topological change (GO:0006265)4.79173888
3DNA replication initiation (GO:0006270)4.63732699
4DNA unwinding involved in DNA replication (GO:0006268)4.56382791
5DNA strand elongation (GO:0022616)4.48860268
6nuclear pore complex assembly (GO:0051292)4.25322045
7nuclear pore organization (GO:0006999)4.10697613
8regulation of translational fidelity (GO:0006450)4.07636655
9COPI coating of Golgi vesicle (GO:0048205)4.06634696
10Golgi transport vesicle coating (GO:0048200)4.06634696
11paraxial mesoderm development (GO:0048339)4.00780240
12DNA replication checkpoint (GO:0000076)3.86886364
13protein localization to kinetochore (GO:0034501)3.70497289
14mitotic nuclear envelope disassembly (GO:0007077)3.70087135
15regulation of histone H3-K27 methylation (GO:0061085)3.65093800
16negative regulation of histone methylation (GO:0031061)3.62749381
17regulation of histone H3-K4 methylation (GO:0051569)3.61938778
18regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61479831
19protein export from nucleus (GO:0006611)3.61466727
20mitotic metaphase plate congression (GO:0007080)3.59047212
21nuclear envelope disassembly (GO:0051081)3.54820435
22membrane disassembly (GO:0030397)3.54820435
23mitotic chromosome condensation (GO:0007076)3.53854646
24NLS-bearing protein import into nucleus (GO:0006607)3.42562075
25telomere maintenance via semi-conservative replication (GO:0032201)3.40041089
26mitotic sister chromatid cohesion (GO:0007064)3.38540200
27chromosome condensation (GO:0030261)3.37076439
28chromosome segregation (GO:0007059)3.36745246
29dosage compensation (GO:0007549)3.36245949
30regulation of RNA export from nucleus (GO:0046831)3.33046256
31cellular protein complex localization (GO:0034629)3.32859900
32sister chromatid segregation (GO:0000819)3.31431472
33IMP metabolic process (GO:0046040)3.30541560
34formation of translation preinitiation complex (GO:0001731)3.30312079
35folic acid-containing compound biosynthetic process (GO:0009396)3.30284950
36regulation of translational termination (GO:0006449)3.30173650
37regulation of translational elongation (GO:0006448)3.30124333
38glucocorticoid receptor signaling pathway (GO:0042921)3.30026162
39heterochromatin organization (GO:0070828)3.27812253
40metaphase plate congression (GO:0051310)3.25420271
41protein complex localization (GO:0031503)3.25295217
42DNA duplex unwinding (GO:0032508)3.24325099
43DNA geometric change (GO:0032392)3.22013126
44spliceosomal tri-snRNP complex assembly (GO:0000244)3.18675353
45proline biosynthetic process (GO:0006561)3.18635214
46translesion synthesis (GO:0019985)3.16175337
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13975007
48regulation of NFAT protein import into nucleus (GO:0051532)3.13289047
49protoporphyrinogen IX metabolic process (GO:0046501)3.12023481
50microtubule depolymerization (GO:0007019)3.10159797
51regulation of spindle organization (GO:0090224)3.08698691
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08334341
53poly(A)+ mRNA export from nucleus (GO:0016973)3.08301029
54tRNA aminoacylation for protein translation (GO:0006418)3.07265806
55regulation of centriole replication (GO:0046599)3.04371443
56DNA packaging (GO:0006323)3.03163866
57purine nucleobase biosynthetic process (GO:0009113)3.02345501
58regulation of chromosome segregation (GO:0051983)3.01703463
59establishment of chromosome localization (GO:0051303)3.01168581
60regulation of histone methylation (GO:0031060)3.00771322
61nuclear envelope organization (GO:0006998)3.00422438
62epithelial cell differentiation involved in prostate gland development (GO:0060742)3.00351145
63regulation of sister chromatid cohesion (GO:0007063)2.98577505
64mRNA export from nucleus (GO:0006406)2.98326598
65DNA ligation (GO:0006266)2.97269353
66pore complex assembly (GO:0046931)2.96192391
67amino acid activation (GO:0043038)2.95229280
68tRNA aminoacylation (GO:0043039)2.95229280
69ribosome assembly (GO:0042255)2.94204145
70protein localization to chromosome, centromeric region (GO:0071459)2.94073125
71RNA export from nucleus (GO:0006405)2.93346357
72DNA replication-dependent nucleosome assembly (GO:0006335)2.93196426
73DNA replication-dependent nucleosome organization (GO:0034723)2.93196426
74RNA transport (GO:0050658)2.93096773
75establishment of RNA localization (GO:0051236)2.93096773
76nucleic acid transport (GO:0050657)2.93096773
77positive regulation of SMAD protein import into nucleus (GO:0060391)2.92837760
78regulation of centrosome cycle (GO:0046605)2.91936734
79peptidyl-lysine dimethylation (GO:0018027)2.89534555
80hippo signaling (GO:0035329)2.87987021
81positive regulation of histone deacetylation (GO:0031065)2.86349913
82regulation of mitotic spindle organization (GO:0060236)2.84410957
83positive regulation of DNA-dependent DNA replication (GO:2000105)2.83606671
84mitotic spindle checkpoint (GO:0071174)2.83587779
85mitotic recombination (GO:0006312)2.82464144
86negative regulation of chromosome segregation (GO:0051985)2.82278436
87spindle checkpoint (GO:0031577)2.80347561
88mitotic sister chromatid segregation (GO:0000070)2.79847119
89regulation of histone H3-K9 methylation (GO:0051570)2.79161635
90glycolytic process (GO:0006096)2.79141344
91regulation of SMAD protein import into nucleus (GO:0060390)2.78331709
92embryonic foregut morphogenesis (GO:0048617)2.77478381
93positive regulation of cell cycle checkpoint (GO:1901978)2.76563367
94kinetochore organization (GO:0051383)2.76465713
95telomere maintenance via recombination (GO:0000722)2.75348440
96retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72999832
97mitotic G1 DNA damage checkpoint (GO:0031571)2.72869400
98vesicle coating (GO:0006901)2.71720884
99histone H3-K9 demethylation (GO:0033169)2.71202103
100corticosteroid receptor signaling pathway (GO:0031958)2.70774248
101mRNA cleavage (GO:0006379)2.70675784
102negative regulation of sister chromatid segregation (GO:0033046)2.69970085
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69970085
104negative regulation of RNA splicing (GO:0033119)2.69416377
105RNA stabilization (GO:0043489)2.68884597
106mRNA stabilization (GO:0048255)2.68884597
107protein-DNA complex disassembly (GO:0032986)2.65936056
108nucleosome disassembly (GO:0006337)2.65936056
109L-alpha-amino acid transmembrane transport (GO:1902475)2.64648959
110cytoplasmic mRNA processing body assembly (GO:0033962)2.63030461
111chromatin assembly (GO:0031497)2.63003355
112histone H2A monoubiquitination (GO:0035518)2.61407023
113regulation of nucleobase-containing compound transport (GO:0032239)2.60387208
114establishment of apical/basal cell polarity (GO:0035089)2.59673815
115negative regulation of mRNA processing (GO:0050686)2.58309368
116antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57527931
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57527931
118postreplication repair (GO:0006301)2.56003065
119negative regulation of cell size (GO:0045792)2.55786189
120gene silencing by RNA (GO:0031047)2.54918683
121regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.53344251
122stress granule assembly (GO:0034063)2.52786797
123intracellular estrogen receptor signaling pathway (GO:0030520)2.51582748
124regulation of cholesterol homeostasis (GO:2000188)2.47622943
125negative regulation of mRNA metabolic process (GO:1903312)2.46650503
126gene silencing (GO:0016458)2.45382151
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.43376508
128DNA conformation change (GO:0071103)2.42491486
129apoptotic process involved in morphogenesis (GO:0060561)2.41380589
130alpha-linolenic acid metabolic process (GO:0036109)2.41177087
131regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40432903
132regulation of DNA damage checkpoint (GO:2000001)2.40325472
133histone mRNA catabolic process (GO:0071044)2.39499330
134positive regulation of chromosome segregation (GO:0051984)2.38529786
135regulation of chromatin binding (GO:0035561)2.38018033
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37705174
137regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36518116
138monoubiquitinated protein deubiquitination (GO:0035520)2.34790954
139regulation of fatty acid beta-oxidation (GO:0031998)2.34691694
140cellular response to epidermal growth factor stimulus (GO:0071364)2.34029569
141DNA strand elongation involved in DNA replication (GO:0006271)2.33283238
142mRNA transport (GO:0051028)2.33155185
143mitotic G1/S transition checkpoint (GO:0044819)2.32971256
144IMP biosynthetic process (GO:0006188)2.32723644
145protein localization to chromosome (GO:0034502)2.32200473
146regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30307087
147histone H4-K8 acetylation (GO:0043982)2.29849153
148histone H4-K5 acetylation (GO:0043981)2.29849153
149lens fiber cell development (GO:0070307)2.28643496
150planar cell polarity pathway involved in neural tube closure (GO:0090179)2.27795624
151nodal signaling pathway (GO:0038092)2.25389068
152G1 DNA damage checkpoint (GO:0044783)2.24552911
1533-UTR-mediated mRNA stabilization (GO:0070935)2.23913020
154regulation of gene silencing by miRNA (GO:0060964)2.23301014
155regulation of gene silencing by RNA (GO:0060966)2.23301014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19770728
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.46153601
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.41931593
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.69124227
5MYC_22102868_ChIP-Seq_BL_Human3.66358185
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91706596
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57119040
8PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.30728206
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29468858
10VDR_21846776_ChIP-Seq_THP-1_Human2.21485375
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21089626
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13598426
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10661978
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07938005
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05547510
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98957349
17AR_21909140_ChIP-Seq_LNCAP_Human1.97231693
18THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94474405
19TCF7_22412390_ChIP-Seq_EML_Mouse1.94349737
20* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92323305
21KDM2B_26808549_Chip-Seq_DND41_Human1.88779444
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88101042
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83673047
24DCP1A_22483619_ChIP-Seq_HELA_Human1.81464078
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75335482
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.75052813
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74802442
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70609251
29CIITA_25753668_ChIP-Seq_RAJI_Human1.68854006
30* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64622202
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.63783442
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59781502
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.57903117
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57413697
35TTF2_22483619_ChIP-Seq_HELA_Human1.56220771
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55272999
37CLOCK_20551151_ChIP-Seq_293T_Human1.55019709
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54747934
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52560876
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52486233
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50155444
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49939299
43* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47158363
44MAF_26560356_Chip-Seq_TH1_Human1.46865700
45UTX_26944678_Chip-Seq_JUKART_Human1.46189010
46* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45709513
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44825957
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43116586
49* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40774888
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40057389
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.39392113
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38314456
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36493297
54NANOG_21062744_ChIP-ChIP_HESCs_Human1.36041609
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.35026153
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34941940
57GATA1_22025678_ChIP-Seq_K562_Human1.34828664
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33265397
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33115772
60GATA1_19941826_ChIP-Seq_K562_Human1.32371519
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.32308075
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32007612
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31651403
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.31199921
65* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30575924
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.30552082
67GABP_19822575_ChIP-Seq_HepG2_Human1.30455110
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28645632
69XRN2_22483619_ChIP-Seq_HELA_Human1.26476433
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25085781
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.25085098
72* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24699707
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23388140
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22388875
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21816513
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20760495
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18641637
78* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16991530
79* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16446819
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15868444
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14182907
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13922328
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13880547
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13875676
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12800262
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12629688
87KDM5A_27292631_Chip-Seq_BREAST_Human1.12560450
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12506246
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11093365
90ATF3_27146783_Chip-Seq_COLON_Human1.09780306
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09611350
92* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09366602
93* NCOR1_26117541_ChIP-Seq_K562_Human1.08671966
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08372589
95* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08283121
96* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07800191
97LXR_22292898_ChIP-Seq_THP-1_Human1.07685812
98ELK1_19687146_ChIP-ChIP_HELA_Human1.07074733
99CHD1_26751641_Chip-Seq_LNCaP_Human1.06874025
100* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06115122
101MYB_26560356_Chip-Seq_TH2_Human1.05515819
102FOXP3_21729870_ChIP-Seq_TREG_Human1.05148239
103PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05079593
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04633884
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04590190
106MYB_26560356_Chip-Seq_TH1_Human1.04291389
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04138026
108TFEB_21752829_ChIP-Seq_HELA_Human1.04123064
109* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01092318
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99974568
111NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99362086
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98756398
113VDR_24763502_ChIP-Seq_THP-1_Human0.97777892
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97175668
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97109923
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96532651
117NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96076817
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94919831
119PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94706022
120SCL_19346495_ChIP-Seq_HPC-7_Human0.94604920
121ZNF263_19887448_ChIP-Seq_K562_Human0.94117352
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93552573
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92917913
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92670155
125GATA2_19941826_ChIP-Seq_K562_Human0.92363973
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92315989
127RACK7_27058665_Chip-Seq_MCF-7_Human0.91598146
128TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90732959
129KDM2B_26808549_Chip-Seq_K562_Human0.90243236
130POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89842819
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88360364
132TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88258146
133* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87800351
134MAF_26560356_Chip-Seq_TH2_Human0.87030266
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85437811
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.85295060
137CREB1_26743006_Chip-Seq_LNCaP_Human0.85005757
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84773071
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84773071
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84773071
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83105920
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82904201
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82607207
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82392126
145* VDR_23849224_ChIP-Seq_CD4+_Human0.81790396
146CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79484934
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78622548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.61555521
2MP0010352_gastrointestinal_tract_polyps3.29951938
3MP0005076_abnormal_cell_differentiation3.12695548
4MP0002653_abnormal_ependyma_morphology3.06410573
5MP0010094_abnormal_chromosome_stability2.54680989
6MP0010307_abnormal_tumor_latency2.50678485
7MP0002009_preneoplasia2.42231027
8MP0003111_abnormal_nucleus_morphology2.36852590
9MP0003077_abnormal_cell_cycle2.33195486
10MP0009697_abnormal_copulation2.28717981
11MP0004147_increased_porphyrin_level2.26766375
12MP0004233_abnormal_muscle_weight2.18177604
13MP0003300_gastrointestinal_ulcer2.15642584
14MP0003221_abnormal_cardiomyocyte_apopto2.12411210
15MP0001730_embryonic_growth_arrest2.04928568
16MP0005451_abnormal_body_composition2.04024842
17MP0000350_abnormal_cell_proliferation2.01851797
18MP0009278_abnormal_bone_marrow2.01324264
19MP0004197_abnormal_fetal_growth/weight/1.93203239
20MP0003656_abnormal_erythrocyte_physiolo1.93051495
21MP0010030_abnormal_orbit_morphology1.88923402
22MP0000733_abnormal_muscle_development1.87113197
23MP0009053_abnormal_anal_canal1.85009220
24MP0004808_abnormal_hematopoietic_stem1.81912718
25MP0000537_abnormal_urethra_morphology1.77480110
26MP0001672_abnormal_embryogenesis/_devel1.72129617
27MP0005380_embryogenesis_phenotype1.72129617
28MP0008995_early_reproductive_senescence1.72028113
29MP0002084_abnormal_developmental_patter1.69904487
30MP0003984_embryonic_growth_retardation1.67949534
31MP0008961_abnormal_basal_metabolism1.66986709
32MP0002088_abnormal_embryonic_growth/wei1.66982948
33MP0001697_abnormal_embryo_size1.65445189
34MP0005023_abnormal_wound_healing1.65239221
35MP0004264_abnormal_extraembryonic_tissu1.64497781
36MP0004957_abnormal_blastocyst_morpholog1.62875518
37MP0003283_abnormal_digestive_organ1.61437076
38MP0003693_abnormal_embryo_hatching1.60937406
39MP0003718_maternal_effect1.60913814
40MP0002085_abnormal_embryonic_tissue1.60120754
41* MP0002086_abnormal_extraembryonic_tissu1.57681290
42MP0002396_abnormal_hematopoietic_system1.55894912
43MP0003566_abnormal_cell_adhesion1.52485660
44MP0008057_abnormal_DNA_replication1.50907186
45MP0001849_ear_inflammation1.46248221
46MP0003890_abnormal_embryonic-extraembry1.45763411
47MP0008007_abnormal_cellular_replicative1.44389673
48MP0003091_abnormal_cell_migration1.40894592
49MP0003115_abnormal_respiratory_system1.39809246
50MP0000569_abnormal_digit_pigmentation1.39743969
51* MP0002080_prenatal_lethality1.37972868
52MP0001293_anophthalmia1.37560848
53MP0003303_peritoneal_inflammation1.34908955
54MP0009840_abnormal_foam_cell1.34904242
55MP0004270_analgesia1.33839669
56MP0003786_premature_aging1.32660905
57MP0003123_paternal_imprinting1.30142617
58MP0001661_extended_life_span1.27137669
59MP0001915_intracranial_hemorrhage1.24295710
60MP0002092_abnormal_eye_morphology1.20557140
61MP0003385_abnormal_body_wall1.18453657
62MP0006035_abnormal_mitochondrial_morpho1.17572948
63MP0000678_abnormal_parathyroid_gland1.13147215
64* MP0000703_abnormal_thymus_morphology1.12805312
65MP0002089_abnormal_postnatal_growth/wei1.09809384
66MP0002697_abnormal_eye_size1.08839090
67MP0002925_abnormal_cardiovascular_devel1.08595408
68* MP0000428_abnormal_craniofacial_morphol1.08000217
69MP0009672_abnormal_birth_weight1.07959432
70MP0003937_abnormal_limbs/digits/tail_de1.07953929
71MP0009703_decreased_birth_body1.07157054
72MP0008058_abnormal_DNA_repair1.06909118
73MP0006054_spinal_hemorrhage1.02383067
74MP0001529_abnormal_vocalization0.98208269
75MP0008438_abnormal_cutaneous_collagen0.97846086
76MP0000685_abnormal_immune_system0.97629480
77MP0003567_abnormal_fetal_cardiomyocyte0.95919399
78MP0010630_abnormal_cardiac_muscle0.95355790
79MP0002932_abnormal_joint_morphology0.94038135
80MP0001929_abnormal_gametogenesis0.93153865
81MP0005621_abnormal_cell_physiology0.92578118
82MP0003119_abnormal_digestive_system0.92339495
83MP0005501_abnormal_skin_physiology0.92023551
84* MP0002019_abnormal_tumor_incidence0.91588150
85MP0005499_abnormal_olfactory_system0.90925291
86MP0005394_taste/olfaction_phenotype0.90925291
87MP0002398_abnormal_bone_marrow0.90812660
88MP0003935_abnormal_craniofacial_develop0.90634398
89MP0000313_abnormal_cell_death0.89462659
90MP0000647_abnormal_sebaceous_gland0.89253458
91MP0005187_abnormal_penis_morphology0.89229055
92MP0000579_abnormal_nail_morphology0.88503338
93MP0000377_abnormal_hair_follicle0.88115747
94MP0002269_muscular_atrophy0.88093197
95MP0000490_abnormal_crypts_of0.86927671
96MP0002234_abnormal_pharynx_morphology0.86218057
97MP0003121_genomic_imprinting0.85430311
98MP0003941_abnormal_skin_development0.85279142
99MP0008260_abnormal_autophagy0.85123275
100MP0000566_synostosis0.85020973
101MP0001727_abnormal_embryo_implantation0.84269728
102MP0003763_abnormal_thymus_physiology0.84080091
103MP0000371_diluted_coat_color0.84067084
104MP0004185_abnormal_adipocyte_glucose0.83583975
105MP0005397_hematopoietic_system_phenotyp0.82693833
106MP0001545_abnormal_hematopoietic_system0.82693833
107MP0004947_skin_inflammation0.82504896
108MP0002722_abnormal_immune_system0.82334352
109* MP0000266_abnormal_heart_morphology0.82294781
110* MP0002111_abnormal_tail_morphology0.82052824
111MP0008932_abnormal_embryonic_tissue0.81824162
112MP0003942_abnormal_urinary_system0.81012487
113MP0004859_abnormal_synaptic_plasticity0.80876731
114MP0003279_aneurysm0.80167236
115MP0003699_abnormal_female_reproductive0.79999957
116MP0000747_muscle_weakness0.79829763
117MP0003861_abnormal_nervous_system0.79031830
118MP0005384_cellular_phenotype0.78995472
119MP0005360_urolithiasis0.78925449
120MP0000003_abnormal_adipose_tissue0.78810959
121MP0000358_abnormal_cell_content/0.78578464
122MP0003448_altered_tumor_morphology0.77953748
123MP0002282_abnormal_trachea_morphology0.77862953
124MP0002210_abnormal_sex_determination0.77606613
125MP0005248_abnormal_Harderian_gland0.76815984
126MP0008770_decreased_survivor_rate0.76686902
127MP0010234_abnormal_vibrissa_follicle0.74784885
128MP0000689_abnormal_spleen_morphology0.73840799
129MP0000534_abnormal_ureter_morphology0.72966915
130MP0000767_abnormal_smooth_muscle0.72861300
131MP0000609_abnormal_liver_physiology0.72431204
132* MP0002081_perinatal_lethality0.71398574
133MP0004087_abnormal_muscle_fiber0.71241354
134MP0001286_abnormal_eye_development0.70159552
135MP0000432_abnormal_head_morphology0.70114571
136MP0002249_abnormal_larynx_morphology0.69701089
137MP0005508_abnormal_skeleton_morphology0.69571048
138MP0002877_abnormal_melanocyte_morpholog0.69258086
139MP0002796_impaired_skin_barrier0.68387419
140MP0004811_abnormal_neuron_physiology0.67765552
141MP0002161_abnormal_fertility/fecundity0.67221549
142MP0001346_abnormal_lacrimal_gland0.67022703
143MP0003698_abnormal_male_reproductive0.63562393

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)6.07343288
2Abnormal gallbladder physiology (HP:0012438)6.07343288
3Hyperacusis (HP:0010780)3.84158917
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.80433145
5Short 4th metacarpal (HP:0010044)3.80433145
6Reticulocytosis (HP:0001923)3.68700583
7* Truncus arteriosus (HP:0001660)3.60231758
8Birth length less than 3rd percentile (HP:0003561)3.44521602
9* Bowel incontinence (HP:0002607)3.44034138
10* Abnormal large intestine physiology (HP:0012700)3.29584201
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26331978
12Renal duplication (HP:0000075)3.13381010
13Abnormality of glycolysis (HP:0004366)3.06986892
14Cholelithiasis (HP:0001081)3.06812150
15Chromsome breakage (HP:0040012)3.04593577
16Hyperthyroidism (HP:0000836)3.03682293
17Abnormality of the 4th metacarpal (HP:0010012)3.02551652
18Ependymoma (HP:0002888)3.01190671
19Cerebral aneurysm (HP:0004944)2.99318658
20Increased nuchal translucency (HP:0010880)2.96458498
21Pseudobulbar signs (HP:0002200)2.96060543
22Renovascular hypertension (HP:0100817)2.91284659
23Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.88834199
24Elfin facies (HP:0004428)2.85232763
25Septate vagina (HP:0001153)2.79602153
26Shallow orbits (HP:0000586)2.77025258
27Peripheral hypomyelination (HP:0007182)2.72628909
28Abnormal gallbladder morphology (HP:0012437)2.72098687
29Protrusio acetabuli (HP:0003179)2.67201098
30Abnormality of homocysteine metabolism (HP:0010919)2.66337723
31Homocystinuria (HP:0002156)2.66337723
32Termporal pattern (HP:0011008)2.65223865
33Insidious onset (HP:0003587)2.65223865
34Dysmetric saccades (HP:0000641)2.64833852
35Abnormality of the astrocytes (HP:0100707)2.61011892
36Astrocytoma (HP:0009592)2.61011892
37Abnormality of reticulocytes (HP:0004312)2.60026287
38Heterotopia (HP:0002282)2.59678617
39Overriding aorta (HP:0002623)2.56994466
40* Ankyloglossia (HP:0010296)2.54910767
41Bowel diverticulosis (HP:0005222)2.47791301
42Increased serum pyruvate (HP:0003542)2.44499463
43Seborrheic dermatitis (HP:0001051)2.42152441
44Abnormality of cochlea (HP:0000375)2.39345267
45Polycythemia (HP:0001901)2.38688518
46Papillary thyroid carcinoma (HP:0002895)2.37325559
47Progressive external ophthalmoplegia (HP:0000590)2.34851761
48Long eyelashes (HP:0000527)2.34643874
49Hand muscle atrophy (HP:0009130)2.33655886
50Hypoparathyroidism (HP:0000829)2.33479499
51Insomnia (HP:0100785)2.32386254
52Aortic aneurysm (HP:0004942)2.31694801
53Increased density of long bones (HP:0006392)2.31649389
54Ankle contracture (HP:0006466)2.29633729
55Trigonocephaly (HP:0000243)2.24323417
56Hypertensive crisis (HP:0100735)2.22389398
57Upper limb muscle weakness (HP:0003484)2.19842021
58Abnormally folded helix (HP:0008544)2.18114658
59Abnormality of the gallbladder (HP:0005264)2.17160696
60Nephroblastoma (Wilms tumor) (HP:0002667)2.17150466
61Flat cornea (HP:0007720)2.13381160
62Exercise-induced muscle cramps (HP:0003710)2.12480853
63Deviation of the thumb (HP:0009603)2.12393113
64Acute myeloid leukemia (HP:0004808)2.10879906
65Proximal placement of thumb (HP:0009623)2.10244126
66High anterior hairline (HP:0009890)2.08828522
67Orthostatic hypotension (HP:0001278)2.07244855
68Neoplasm of the oral cavity (HP:0100649)2.06802175
69Mitral valve prolapse (HP:0001634)2.06115356
70Abnormality of the lower motor neuron (HP:0002366)2.05723382
71Bladder diverticulum (HP:0000015)2.04964614
72Macroorchidism (HP:0000053)2.04266922
73Deep philtrum (HP:0002002)2.03873838
74Pelvic girdle muscle weakness (HP:0003749)2.03763413
75Upper limb amyotrophy (HP:0009129)2.03522112
76Distal upper limb amyotrophy (HP:0007149)2.03522112
77Poikilocytosis (HP:0004447)2.02975186
78Aplasia/Hypoplasia of the sternum (HP:0006714)2.02950817
79Cafe-au-lait spot (HP:0000957)2.02833484
80Gastrointestinal carcinoma (HP:0002672)2.01430647
81Malignant gastrointestinal tract tumors (HP:0006749)2.01430647
82Broad thumb (HP:0011304)2.00992950
83Glioma (HP:0009733)2.00574866
84Spastic diplegia (HP:0001264)2.00098502
85Pheochromocytoma (HP:0002666)1.99454882
86Shoulder girdle muscle weakness (HP:0003547)1.98810538
87Hallux valgus (HP:0001822)1.98637032
88Multiple enchondromatosis (HP:0005701)1.98355891
89Selective tooth agenesis (HP:0001592)1.97819282
90Genu recurvatum (HP:0002816)1.96323391
91Myelodysplasia (HP:0002863)1.96310763
92Cortical dysplasia (HP:0002539)1.96217985
93Deviation of the hallux (HP:0010051)1.95562316
94Patellar dislocation (HP:0002999)1.95093651
95Abnormality of the fingertips (HP:0001211)1.93303435
96Embryonal renal neoplasm (HP:0011794)1.92947751
97Medulloblastoma (HP:0002885)1.92870622
98* Attention deficit hyperactivity disorder (HP:0007018)1.92636152
99Abnormality of the diencephalon (HP:0010662)1.92534525
100* Pointed chin (HP:0000307)1.92159058
101Hammertoe (HP:0001765)1.91609268
102Acanthocytosis (HP:0001927)1.91525313
103Short 5th finger (HP:0009237)1.90910103
104Centrally nucleated skeletal muscle fibers (HP:0003687)1.90688493
105Ulnar bowing (HP:0003031)1.90560532
106Megalocornea (HP:0000485)1.90120366
107Morphological abnormality of the inner ear (HP:0011390)1.89648748
108Abnormality of the tricuspid valve (HP:0001702)1.89526157
109Abnormality of the salivary glands (HP:0010286)1.89210237
110Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.89080868
111Lymphangioma (HP:0100764)1.84726861
112Aneurysm (HP:0002617)1.84658599
113Metaphyseal cupping (HP:0003021)1.84295807
114Fatigue (HP:0012378)1.84221153
115Abnormality of chromosome segregation (HP:0002916)1.83930779
116Basal cell carcinoma (HP:0002671)1.83720621
117Colon cancer (HP:0003003)1.83570421
118Abnormality of the heme biosynthetic pathway (HP:0010472)1.83552178
119Cutis marmorata (HP:0000965)1.83369560
120Rib fusion (HP:0000902)1.82431984
121Abnormality of nail color (HP:0100643)1.81125469
122Skin tags (HP:0010609)1.81044637
123* Obsessive-compulsive behavior (HP:0000722)1.80590766
124Breech presentation (HP:0001623)1.80515409
125Sacral dimple (HP:0000960)1.78154652
126Progressive muscle weakness (HP:0003323)1.77996633
127* Abnormality of oral frenula (HP:0000190)1.77313656
128Neoplasm of the heart (HP:0100544)1.76910501
129Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76536845
130Fibroma (HP:0010614)1.75525419
131Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.75421295
132Disproportionate tall stature (HP:0001519)1.75342308
133Wrist flexion contracture (HP:0001239)1.75014857
134Fibrous tissue neoplasm (HP:0012316)1.74239975
135Broad metatarsal (HP:0001783)1.74168829
136Broad palm (HP:0001169)1.74127537
137Embryonal neoplasm (HP:0002898)1.73779906
138Spina bifida occulta (HP:0003298)1.72952794
139Prominent nose (HP:0000448)1.72351391
140Abnormal number of incisors (HP:0011064)1.72174784
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68669633
142Skull defect (HP:0001362)1.68412787
143Narrow palate (HP:0000189)1.68308371
144Abnormality of the labia minora (HP:0012880)1.67908656
145Overfolded helix (HP:0000396)1.67246832
146Abnormality of the anterior horn cell (HP:0006802)1.67220597
147Degeneration of anterior horn cells (HP:0002398)1.67220597
148* Cheekbone underdevelopment (HP:0010669)1.67214311
149Biliary tract neoplasm (HP:0100574)1.67058158
150Relative macrocephaly (HP:0004482)1.66261467
151Atelectasis (HP:0100750)1.65724269
152Thyroid carcinoma (HP:0002890)1.65563883
153Striae distensae (HP:0001065)1.64989895
154Bicuspid aortic valve (HP:0001647)1.64412268
155Spinal muscular atrophy (HP:0007269)1.64278798
156Hepatoblastoma (HP:0002884)1.64162277
157Abnormality of the musculature of the pelvis (HP:0001469)1.63527058
158Abnormality of the hip-girdle musculature (HP:0001445)1.63527058
159Neoplasm of striated muscle (HP:0009728)1.63171978
160Neuroblastic tumors (HP:0004376)1.62842773
161Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.62842773
162Neuroblastoma (HP:0003006)1.62842773
163Primitive neuroectodermal tumor (HP:0030065)1.62842773
164Broad phalanges of the hand (HP:0009768)1.62507136
165Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61015235
166Cutaneous melanoma (HP:0012056)1.60946966
167Limited elbow extension (HP:0001377)1.58904299
168Enlarged penis (HP:0000040)1.56845755
169Volvulus (HP:0002580)1.56237926
170High pitched voice (HP:0001620)1.55669548
171Abnormality of the peritoneum (HP:0002585)1.54008105
172Facial hemangioma (HP:0000329)1.53907024
173Uterine leiomyosarcoma (HP:0002891)1.53704123
174Leiomyosarcoma (HP:0100243)1.53704123
175Overlapping toe (HP:0001845)1.52840488
176Low anterior hairline (HP:0000294)1.52367526
177Long palpebral fissure (HP:0000637)1.52180077
178Hypopigmentation of the fundus (HP:0007894)1.52046055
179Short phalanx of the thumb (HP:0009660)1.51996779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.81859504
2CDK123.62109991
3EEF2K3.39860743
4TRIB33.36200319
5SRPK12.86438867
6PKN22.84701773
7RAF12.35544677
8CDC72.22622115
9SIK12.18857718
10MAP3K22.04036992
11ERN12.03070214
12NEK22.00287256
13CLK11.97664632
14NEK11.91439721
15KSR11.89792255
16SIK31.84441779
17PDGFRA1.82017689
18FGFR41.76942006
19RIPK41.74816185
20STK101.69476150
21TYRO31.65040962
22ICK1.63645468
23LATS11.57382596
24PTK61.52345550
25SCYL21.49199365
26MTOR1.48446439
27BRD41.48153714
28CCNB11.45882691
29TTN1.44495561
30PLK41.43592914
31RIPK11.43384914
32PRPF4B1.42207500
33FGFR21.40917246
34SMG11.40916524
35NTRK31.30325670
36CAMK1D1.25565368
37TESK21.25016341
38CDK41.24942588
39MAP4K11.21670418
40ALK1.20758470
41LRRK21.19368737
42PLK31.19356230
43YES11.19199864
44RPS6KB21.17564148
45FGFR31.16680692
46CDK61.14817835
47WEE11.13907219
48PAK41.12989187
49FGFR11.11926446
50PBK1.10505813
51PASK1.01812248
52CDK71.01482215
53MAP3K80.98620481
54BMPR20.98613785
55MKNK10.97323896
56ATR0.96589509
57TGFBR10.94786993
58STK30.94579898
59BCR0.94096756
60CAMK1G0.92273916
61EIF2AK30.92033307
62TAOK10.91235516
63MAP3K40.89814735
64STK40.88740754
65PDGFRB0.87810386
66LATS20.87575795
67CHEK10.86391868
68DMPK0.85494608
69MELK0.83558849
70LMTK20.83518650
71GRK60.83266531
72BMX0.82064021
73FLT30.81181887
74TTK0.74419136
75NTRK20.73799428
76NME10.72803743
77SIK20.72663466
78RPS6KA40.72369648
79TYK20.71785418
80TNIK0.70857857
81DDR20.70004082
82BUB10.69981808
83ERBB20.69580950
84MAP2K30.69473763
85BRSK10.68610699
86MAP3K70.68071370
87PLK10.67541406
88CDK20.66213041
89CDK180.65638587
90CDK150.64467582
91CDK140.64113539
92JAK20.63160087
93CHEK20.63122332
94AURKB0.63003388
95TGFBR20.62992128
96NTRK10.62299433
97CSF1R0.61647059
98PAK20.60812513
99JAK30.60321410
100KSR20.60012006
101RET0.59598270
102CDK11A0.58633203
103EIF2AK20.57704800
104BRAF0.56678616
105ITK0.54097484
106PTK20.52982308
107MAP2K10.52904565
108EPHB10.51451867
109* MAPK100.51146178
110CHUK0.50448079
111EIF2AK10.50393161
112MARK30.50357834
113ATM0.49719728
114JAK10.49322658
115MAP3K90.48738138
116MAP3K10.47443472
117* CDK10.47418461
118TSSK60.46557138
119AURKA0.45938470
120DYRK1B0.44615737
121NEK60.44228665
122AKT20.43777178
123PIM10.43442480
124CSK0.41750652
125HCK0.41644737
126EPHA30.41075612
127MAP3K130.40974660
128CDK90.40931255
129DYRK30.40540324
130BRSK20.39949697
131EPHB20.39696513
132CSNK1E0.39568781
133MAPK110.38815849
134* GSK3B0.37819620
135MAPKAPK50.36937805
136PNCK0.36137913
137TRIM280.36071445
138CSNK1A1L0.35203261
139PAK10.34998933
140MAPKAPK30.34757878
141EGFR0.34463115
142ZAP700.34277966
143PAK60.34253513

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.26311592
2Nitrogen metabolism_Homo sapiens_hsa009102.76703363
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.13946320
4Cell cycle_Homo sapiens_hsa041101.96433662
5Lysine degradation_Homo sapiens_hsa003101.90235139
6One carbon pool by folate_Homo sapiens_hsa006701.87999631
7* Chronic myeloid leukemia_Homo sapiens_hsa052201.84527261
8DNA replication_Homo sapiens_hsa030301.83292245
9Notch signaling pathway_Homo sapiens_hsa043301.69166441
10mTOR signaling pathway_Homo sapiens_hsa041501.64664732
11* MicroRNAs in cancer_Homo sapiens_hsa052061.55906717
12RNA transport_Homo sapiens_hsa030131.54092000
13mRNA surveillance pathway_Homo sapiens_hsa030151.47563214
14Nucleotide excision repair_Homo sapiens_hsa034201.47248616
15Colorectal cancer_Homo sapiens_hsa052101.47168189
16Mismatch repair_Homo sapiens_hsa034301.43259851
17Basal cell carcinoma_Homo sapiens_hsa052171.41440265
18Non-small cell lung cancer_Homo sapiens_hsa052231.37794037
19* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37554018
20Fanconi anemia pathway_Homo sapiens_hsa034601.35812259
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34974387
22Pancreatic cancer_Homo sapiens_hsa052121.34071121
23Small cell lung cancer_Homo sapiens_hsa052221.33756214
24Spliceosome_Homo sapiens_hsa030401.29812083
25Hippo signaling pathway_Homo sapiens_hsa043901.29711167
26Viral carcinogenesis_Homo sapiens_hsa052031.29524338
27Biosynthesis of amino acids_Homo sapiens_hsa012301.29132949
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.26822234
29Proteoglycans in cancer_Homo sapiens_hsa052051.25964418
30Steroid biosynthesis_Homo sapiens_hsa001001.25738309
31Adherens junction_Homo sapiens_hsa045201.25167036
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22724938
33Viral myocarditis_Homo sapiens_hsa054161.21692591
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21104655
35Base excision repair_Homo sapiens_hsa034101.17780151
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16643655
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15938666
38Bladder cancer_Homo sapiens_hsa052191.15202780
39HTLV-I infection_Homo sapiens_hsa051661.15183963
40Endometrial cancer_Homo sapiens_hsa052131.12373339
41Homologous recombination_Homo sapiens_hsa034401.11851043
42* ErbB signaling pathway_Homo sapiens_hsa040121.11443721
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10217617
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.09727235
45p53 signaling pathway_Homo sapiens_hsa041151.09513460
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07278667
47Insulin resistance_Homo sapiens_hsa049311.03485422
48* Neurotrophin signaling pathway_Homo sapiens_hsa047221.03248119
49Selenocompound metabolism_Homo sapiens_hsa004501.02075877
50Glioma_Homo sapiens_hsa052141.00789120
51Fructose and mannose metabolism_Homo sapiens_hsa000511.00572849
52Arginine biosynthesis_Homo sapiens_hsa002200.96866675
53Hepatitis B_Homo sapiens_hsa051610.96612070
54Hedgehog signaling pathway_Homo sapiens_hsa043400.95886594
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94393382
56B cell receptor signaling pathway_Homo sapiens_hsa046620.94352936
57* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93877568
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92865757
59TGF-beta signaling pathway_Homo sapiens_hsa043500.91623793
60Acute myeloid leukemia_Homo sapiens_hsa052210.90733847
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89675634
62Pyruvate metabolism_Homo sapiens_hsa006200.87699689
63Dorso-ventral axis formation_Homo sapiens_hsa043200.87376939
64Non-homologous end-joining_Homo sapiens_hsa034500.85523779
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85161201
66AMPK signaling pathway_Homo sapiens_hsa041520.84186979
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84054192
68T cell receptor signaling pathway_Homo sapiens_hsa046600.83627495
69Inositol phosphate metabolism_Homo sapiens_hsa005620.83243747
70Apoptosis_Homo sapiens_hsa042100.82727058
71Long-term potentiation_Homo sapiens_hsa047200.80951176
72Systemic lupus erythematosus_Homo sapiens_hsa053220.79888426
73Herpes simplex infection_Homo sapiens_hsa051680.79686565
74Oocyte meiosis_Homo sapiens_hsa041140.77594874
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76795519
76RNA degradation_Homo sapiens_hsa030180.76619564
77* Focal adhesion_Homo sapiens_hsa045100.75327099
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75033944
79VEGF signaling pathway_Homo sapiens_hsa043700.74503150
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74068661
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73035613
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72664743
83Antigen processing and presentation_Homo sapiens_hsa046120.71869259
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71681931
85Epstein-Barr virus infection_Homo sapiens_hsa051690.70808760
86* Pathways in cancer_Homo sapiens_hsa052000.70755608
87* Insulin signaling pathway_Homo sapiens_hsa049100.70217140
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69621659
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69521610
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.68526829
91Prostate cancer_Homo sapiens_hsa052150.67861733
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67007677
93FoxO signaling pathway_Homo sapiens_hsa040680.66445492
94Primary immunodeficiency_Homo sapiens_hsa053400.65639943
95Basal transcription factors_Homo sapiens_hsa030220.64575954
96Prolactin signaling pathway_Homo sapiens_hsa049170.63793819
97Carbon metabolism_Homo sapiens_hsa012000.62187323
98Thyroid cancer_Homo sapiens_hsa052160.62097317
99* Renal cell carcinoma_Homo sapiens_hsa052110.61986411
100Pentose phosphate pathway_Homo sapiens_hsa000300.61886413
101Toxoplasmosis_Homo sapiens_hsa051450.60820870
102Choline metabolism in cancer_Homo sapiens_hsa052310.60509973
103HIF-1 signaling pathway_Homo sapiens_hsa040660.60080958
104Gap junction_Homo sapiens_hsa045400.59956741
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.58811011
106* Shigellosis_Homo sapiens_hsa051310.57373520
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56652366
108Osteoclast differentiation_Homo sapiens_hsa043800.56418716
109Prion diseases_Homo sapiens_hsa050200.56378144
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56331071
111Measles_Homo sapiens_hsa051620.54691327
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.54551073
113Type II diabetes mellitus_Homo sapiens_hsa049300.53305148
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.52965981
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52386013
116Influenza A_Homo sapiens_hsa051640.49392014
117Estrogen signaling pathway_Homo sapiens_hsa049150.49118781
118Alcoholism_Homo sapiens_hsa050340.47584014
119Leishmaniasis_Homo sapiens_hsa051400.47459155
120Legionellosis_Homo sapiens_hsa051340.47255882
121TNF signaling pathway_Homo sapiens_hsa046680.47236964
122Pyrimidine metabolism_Homo sapiens_hsa002400.46744497
123Circadian rhythm_Homo sapiens_hsa047100.46548910
124Fatty acid biosynthesis_Homo sapiens_hsa000610.46163818
125Glucagon signaling pathway_Homo sapiens_hsa049220.45487696
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45222460
127Fatty acid metabolism_Homo sapiens_hsa012120.44764334
128Long-term depression_Homo sapiens_hsa047300.44049435
129N-Glycan biosynthesis_Homo sapiens_hsa005100.43702155
130Vitamin B6 metabolism_Homo sapiens_hsa007500.42257119
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.42171737
132RNA polymerase_Homo sapiens_hsa030200.38145377
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29754590
134Melanoma_Homo sapiens_hsa052180.28893166

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