CRLF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)7.14941936
2chondrocyte proliferation (GO:0035988)6.53756970
3peptidyl-glutamic acid carboxylation (GO:0017187)6.49537175
4protein carboxylation (GO:0018214)6.49537175
5protein heterotrimerization (GO:0070208)6.34388195
6sequestering of extracellular ligand from receptor (GO:0035581)6.31040379
7skin morphogenesis (GO:0043589)6.26270747
8wound healing, spreading of epidermal cells (GO:0035313)6.21928220
9cell adhesion mediated by integrin (GO:0033627)5.93830378
10very-low-density lipoprotein particle assembly (GO:0034379)5.89089041
11peptidyl-proline hydroxylation (GO:0019511)5.87837523
12positive regulation of endothelial cell apoptotic process (GO:2000353)5.78195840
13regulation of apoptotic cell clearance (GO:2000425)5.73358486
14endodermal cell differentiation (GO:0035987)5.63708288
15plasma lipoprotein particle assembly (GO:0034377)5.45596519
16protein-lipid complex assembly (GO:0065005)5.15355788
17wound healing, spreading of cells (GO:0044319)5.14299113
18bone trabecula formation (GO:0060346)5.06704085
19intestinal cholesterol absorption (GO:0030299)5.05635484
20low-density lipoprotein particle remodeling (GO:0034374)5.02977300
21protein retention in ER lumen (GO:0006621)4.97042154
22regulation of fibrinolysis (GO:0051917)4.95192381
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.92916923
24negative regulation of fatty acid transport (GO:2000192)4.80131869
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.78070437
26protein hydroxylation (GO:0018126)4.70712744
27regulation of tight junction assembly (GO:2000810)4.63291934
28regulation of complement activation (GO:0030449)4.60607749
29regulation of protein activation cascade (GO:2000257)4.57303525
30dermatan sulfate biosynthetic process (GO:0030208)4.56048866
31epithelial cell-cell adhesion (GO:0090136)4.38730815
32cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.26129355
33regulation of cholesterol esterification (GO:0010872)4.19194993
34axon extension involved in axon guidance (GO:0048846)4.18024439
35neuron projection extension involved in neuron projection guidance (GO:1902284)4.18024439
36collagen metabolic process (GO:0032963)4.11245984
37dermatan sulfate metabolic process (GO:0030205)4.10823219
38fibril organization (GO:0097435)4.05912984
39retina vasculature morphogenesis in camera-type eye (GO:0061299)4.04266347
40extracellular matrix assembly (GO:0085029)4.03719764
41collagen catabolic process (GO:0030574)4.02683236
42extracellular fibril organization (GO:0043206)4.01760794
43positive regulation of blood vessel endothelial cell migration (GO:0043536)3.99918985
44epoxygenase P450 pathway (GO:0019373)3.99239381
45cell proliferation involved in metanephros development (GO:0072203)3.96103274
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.93619990
47regulation of cholesterol homeostasis (GO:2000188)3.92477493
48lung epithelium development (GO:0060428)3.91344241
49plasma lipoprotein particle organization (GO:0071827)3.90038630
50protein-lipid complex remodeling (GO:0034368)3.89489674
51macromolecular complex remodeling (GO:0034367)3.89489674
52plasma lipoprotein particle remodeling (GO:0034369)3.89489674
53regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.89460273
54cholesterol efflux (GO:0033344)3.89285787
55protein-lipid complex subunit organization (GO:0071825)3.82971437
56COPI coating of Golgi vesicle (GO:0048205)3.82547563
57Golgi transport vesicle coating (GO:0048200)3.82547563
58mesenchymal-epithelial cell signaling (GO:0060638)3.82111429
59multicellular organismal macromolecule metabolic process (GO:0044259)3.82011623
60multicellular organismal catabolic process (GO:0044243)3.79618433
61extracellular matrix disassembly (GO:0022617)3.79551356
62regulation of extracellular matrix disassembly (GO:0010715)3.77795045
63regulation of plasminogen activation (GO:0010755)3.77709075
64positive regulation of fibroblast migration (GO:0010763)3.76261527
65negative regulation of fibrinolysis (GO:0051918)3.75010012
66omega-hydroxylase P450 pathway (GO:0097267)3.70797523
67multicellular organismal metabolic process (GO:0044236)3.69559877
68regulation of cholesterol biosynthetic process (GO:0045540)3.67503947
69low-density lipoprotein particle clearance (GO:0034383)3.66682628
70negative regulation of protein activation cascade (GO:2000258)3.66582489
71negative regulation of chondrocyte differentiation (GO:0032331)3.63185615
72apoptotic cell clearance (GO:0043277)3.61088873
73proline biosynthetic process (GO:0006561)3.59446069
74craniofacial suture morphogenesis (GO:0097094)3.58968466
75positive regulation of epithelial to mesenchymal transition (GO:0010718)3.58159533
76regulation of integrin-mediated signaling pathway (GO:2001044)3.57585763
77blood coagulation, intrinsic pathway (GO:0007597)3.53384332
78regulation of extracellular matrix organization (GO:1903053)3.51668571
79positive regulation of macrophage activation (GO:0043032)3.48759586
80endocardial cushion development (GO:0003197)3.47081349
81cellular response to vitamin (GO:0071295)3.46590010
82proline metabolic process (GO:0006560)3.41184387
83plasma lipoprotein particle clearance (GO:0034381)3.40665979
84protein localization to cell surface (GO:0034394)3.40307701
85pinocytosis (GO:0006907)3.39122093
86substrate-dependent cell migration (GO:0006929)3.35652900
87negative regulation of smooth muscle cell migration (GO:0014912)3.34272790
88cellular response to vitamin D (GO:0071305)3.33531723
89basement membrane organization (GO:0071711)3.31971511
90stress fiber assembly (GO:0043149)3.30239607
91tooth mineralization (GO:0034505)3.28309939
92intestinal absorption (GO:0050892)3.28213741
93cellular zinc ion homeostasis (GO:0006882)3.26705637
94regulation of metalloenzyme activity (GO:0048552)3.26473898
95extracellular matrix organization (GO:0030198)3.25815461
96cell proliferation involved in kidney development (GO:0072111)3.25405201
97extracellular structure organization (GO:0043062)3.24699911
98vascular endothelial growth factor signaling pathway (GO:0038084)3.23833007
99negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.22018980
100type B pancreatic cell proliferation (GO:0044342)3.21424976
101plasma membrane repair (GO:0001778)3.21290563
102cellular response to interferon-alpha (GO:0035457)3.21268584
103negative regulation of complement activation (GO:0045916)3.20923585
104negative regulation of adherens junction organization (GO:1903392)3.18439300
105negative regulation of focal adhesion assembly (GO:0051895)3.18439300
106negative regulation of cell junction assembly (GO:1901889)3.18439300
107regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.18311523
108cell migration involved in sprouting angiogenesis (GO:0002042)3.17414094
1094-hydroxyproline metabolic process (GO:0019471)3.15648919
110positive regulation of hormone metabolic process (GO:0032352)3.14515419
111endothelial cell morphogenesis (GO:0001886)3.12687108
112negative regulation of embryonic development (GO:0045992)3.12674667
113metanephric mesenchyme development (GO:0072075)3.11652281
114positive regulation of extracellular matrix organization (GO:1903055)3.09333918
115cell-substrate junction assembly (GO:0007044)3.07887086
116extracellular regulation of signal transduction (GO:1900115)3.07308520
117extracellular negative regulation of signal transduction (GO:1900116)3.07308520
118chondroitin sulfate biosynthetic process (GO:0030206)3.06952804
119protein targeting to plasma membrane (GO:0072661)3.06561675
120regulation of bile acid biosynthetic process (GO:0070857)3.00687506
121triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.99193959
122positive regulation of collagen metabolic process (GO:0010714)2.99016832
123glomerular basement membrane development (GO:0032836)2.98481330
124kidney mesenchyme development (GO:0072074)2.98063107
125reverse cholesterol transport (GO:0043691)2.95310147
126high-density lipoprotein particle remodeling (GO:0034375)2.95233783
127positive regulation of osteoblast proliferation (GO:0033690)2.93528415
128cranial suture morphogenesis (GO:0060363)2.91632341
129negative regulation of cartilage development (GO:0061037)2.90324129
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.89493932
131substrate adhesion-dependent cell spreading (GO:0034446)2.88150532
132platelet degranulation (GO:0002576)2.88063790
133cellular response to amino acid stimulus (GO:0071230)2.87608477
134adherens junction assembly (GO:0034333)2.86508538
135positive regulation of hormone biosynthetic process (GO:0046886)2.85627065
136response to muscle activity (GO:0014850)2.84715585
137wound healing (GO:0042060)2.84486254
138hippo signaling (GO:0035329)2.84452698
139activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.82285398
140positive regulation of steroid metabolic process (GO:0045940)2.82285188
141renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.81608569
142muscle cell migration (GO:0014812)2.80337860
143COPII vesicle coating (GO:0048208)2.79808632
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.79379747
145regulation of cartilage development (GO:0061035)2.79163937
146regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.78809510
147embryonic retina morphogenesis in camera-type eye (GO:0060059)2.78592320
148polarized epithelial cell differentiation (GO:0030859)2.78405393
149regulation of monocyte chemotaxis (GO:0090025)2.77770800
150negative regulation of sodium ion transport (GO:0010766)2.76716422
151virion attachment to host cell (GO:0019062)2.76380220
152adhesion of symbiont to host cell (GO:0044650)2.76380220
153positive regulation of collagen biosynthetic process (GO:0032967)2.76244248
154response to fluid shear stress (GO:0034405)2.76182331
155lipoprotein metabolic process (GO:0042157)2.75681213
156positive regulation of dendritic spine morphogenesis (GO:0061003)2.74457305
157regulation of non-canonical Wnt signaling pathway (GO:2000050)2.69981509
158glutamate metabolic process (GO:0006536)2.67816709
159positive regulation of phagocytosis (GO:0050766)2.67133477
160response to prostaglandin (GO:0034694)2.63787616
161L-phenylalanine metabolic process (GO:0006558)2.63117414
162erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63117414
163cellular response to prostaglandin stimulus (GO:0071379)2.60451036
164embryonic process involved in female pregnancy (GO:0060136)2.60179112
165sterol transport (GO:0015918)2.59877612
166cholesterol transport (GO:0030301)2.59877612
167negative regulation of catenin import into nucleus (GO:0035414)2.58833412
168regulation of collagen biosynthetic process (GO:0032965)2.58233045
169diacylglycerol metabolic process (GO:0046339)2.56457233
170vitamin transmembrane transport (GO:0035461)2.53584914
171muscle cell proliferation (GO:0033002)2.53389598
172nephron tubule morphogenesis (GO:0072078)2.52560661
173nephron epithelium morphogenesis (GO:0072088)2.52560661
174fibrinolysis (GO:0042730)2.51209828
175modified amino acid transport (GO:0072337)2.50914782
176positive regulation of hemostasis (GO:1900048)2.50737084
177positive regulation of blood coagulation (GO:0030194)2.50737084
178hyaluronan metabolic process (GO:0030212)2.50601081
179peptidyl-glutamic acid modification (GO:0018200)2.48947831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.13823971
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.47815080
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.70678715
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.93196253
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.15711517
6RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.51764878
7ZNF263_19887448_ChIP-Seq_K562_Human3.23792692
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.96919154
9CLOCK_20551151_ChIP-Seq_293T_Human2.94303818
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76813164
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73816311
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.70285799
13FOXA2_19822575_ChIP-Seq_HepG2_Human2.65624843
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54222743
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.46977936
16CJUN_26792858_Chip-Seq_BT549_Human2.35523941
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.33479957
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.32112402
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28337923
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.25829471
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25756202
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.24818438
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16582594
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.13566048
25BRD4_25478319_ChIP-Seq_HGPS_Human2.09250859
26HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07118584
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02354392
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.00732885
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.98859320
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.96676139
31ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.80647838
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.79550232
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.79452438
34SMC1_22415368_ChIP-Seq_MEFs_Mouse1.78592886
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.78293210
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76865062
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76865062
38ATF3_27146783_Chip-Seq_COLON_Human1.74153433
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.71938694
40* TP53_20018659_ChIP-ChIP_R1E_Mouse1.71032003
41TP53_23651856_ChIP-Seq_MEFs_Mouse1.68415594
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66274262
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66045012
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65712003
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65712003
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.65199619
47SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.64290055
48* HNF4A_19822575_ChIP-Seq_HepG2_Human1.62961831
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.62360180
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62141390
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60118786
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60004463
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59268298
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.57302944
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57156188
56* TP53_22127205_ChIP-Seq_IMR90_Human1.56635160
57RACK7_27058665_Chip-Seq_MCF-7_Human1.52674372
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49699713
59SMC3_22415368_ChIP-Seq_MEFs_Mouse1.49281346
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46472993
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42426011
62AR_21909140_ChIP-Seq_LNCAP_Human1.42247094
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41316776
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.40498015
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39830154
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.36667926
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36630125
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36491130
69TP53_18474530_ChIP-ChIP_U2OS_Human1.35979534
70UBF1/2_26484160_Chip-Seq_HMECs_Human1.34481459
71* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34402399
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34327000
73TP53_16413492_ChIP-PET_HCT116_Human1.33490196
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33097477
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.32967335
76LXR_22292898_ChIP-Seq_THP-1_Human1.32707633
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32421072
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32310737
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31533594
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29589599
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28727690
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26617296
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26056672
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25117278
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24917643
86SOX2_20726797_ChIP-Seq_SW620_Human1.24054103
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22856681
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22748795
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21892680
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21867387
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21479411
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20850935
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.20515210
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19169996
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18494060
96STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.17059328
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16797010
98* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16677165
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14421767
100CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14140111
101SMC4_20622854_ChIP-Seq_HELA_Human1.13573428
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13240142
103* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12519728
104* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12519728
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11924952
106* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11399052
107SA1_22415368_ChIP-Seq_MEFs_Mouse1.10542050
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08140163
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07828430
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07726205
111SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06515422
112FOXO3_23340844_ChIP-Seq_DLD1_Human1.06237371
113* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04851816
114* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02957728
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02295848
116KLF5_25053715_ChIP-Seq_YYC3_Human1.02240239
117TCF4_18268006_ChIP-ChIP_LS174T_Human1.01963642
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01939235
119TBX20_22328084_ChIP-Seq_HEART_Mouse1.00926019
120TBX20_22080862_ChIP-Seq_HEART_Mouse1.00926019
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96704087
122NFI_21473784_ChIP-Seq_ESCs_Mouse0.96691435
123* KDM2B_26808549_Chip-Seq_K562_Human0.96616028
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96578643
125RARA_24833708_ChIP-Seq_LIVER_Mouse0.96488988
126KDM2B_26808549_Chip-Seq_DND41_Human0.96011560
127* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94522797
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94428499
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93535772
130* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93285292
131* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92922188
132TET1_21451524_ChIP-Seq_MESCs_Mouse0.92859406
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92847085
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92609555
135CREB1_26743006_Chip-Seq_LNCaP_Human0.90599570
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90210454
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.90097692
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90029820
139KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89510247
140P68_20966046_ChIP-Seq_HELA_Human0.88146250
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83481268
142CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82123821
143* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79413392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.58089660
2MP0003705_abnormal_hypodermis_morpholog5.41270420
3MP0003279_aneurysm5.26638715
4MP0005275_abnormal_skin_tensile5.26202158
5MP0005503_abnormal_tendon_morphology4.87255521
6MP0001958_emphysema3.81321856
7MP0003122_maternal_imprinting3.79768369
8MP0009384_cardiac_valve_regurgitation3.61813775
9MP0005360_urolithiasis3.19470628
10MP0009780_abnormal_chondrocyte_physiolo3.13614817
11MP0006054_spinal_hemorrhage2.66378977
12MP0000566_synostosis2.62301611
13MP0005623_abnormal_meninges_morphology2.54139552
14MP0002295_abnormal_pulmonary_circulatio2.48210579
15MP0005257_abnormal_intraocular_pressure2.39774352
16MP0003566_abnormal_cell_adhesion2.39427463
17MP0010352_gastrointestinal_tract_polyps2.38150720
18MP0005023_abnormal_wound_healing2.26490960
19MP0010030_abnormal_orbit_morphology2.24876365
20MP0004272_abnormal_basement_membrane2.12543753
21MP0005508_abnormal_skeleton_morphology2.07686692
22MP0002060_abnormal_skin_morphology2.04686830
23MP0005058_abnormal_lysosome_morphology2.00165176
24MP0003123_paternal_imprinting2.00030182
25MP0003091_abnormal_cell_migration1.97083840
26MP0001348_abnormal_lacrimal_gland1.95272458
27MP0001542_abnormal_bone_strength1.87015718
28MP0010329_abnormal_lipoprotein_level1.76565134
29MP0001243_abnormal_dermal_layer1.68839813
30MP0003172_abnormal_lysosome_physiology1.66058708
31MP0005409_darkened_coat_color1.65459620
32MP0005365_abnormal_bile_salt1.64132935
33MP0009250_abnormal_appendicular_skeleto1.55724920
34MP0000013_abnormal_adipose_tissue1.53441526
35MP0001299_abnormal_eye_distance/1.52465131
36MP0004858_abnormal_nervous_system1.50222455
37MP0003385_abnormal_body_wall1.48608351
38MP0001666_abnormal_nutrient_absorption1.48017060
39MP0002139_abnormal_hepatobiliary_system1.39586183
40MP0002896_abnormal_bone_mineralization1.36846984
41MP0002108_abnormal_muscle_morphology1.31254578
42MP0000767_abnormal_smooth_muscle1.30430733
43MP0000733_abnormal_muscle_development1.28893987
44MP0003283_abnormal_digestive_organ1.27929461
45MP0001661_extended_life_span1.27156992
46MP0005451_abnormal_body_composition1.26402474
47MP0005390_skeleton_phenotype1.24923113
48MP0002877_abnormal_melanocyte_morpholog1.22390759
49MP0002933_joint_inflammation1.21895230
50MP0004134_abnormal_chest_morphology1.19993867
51MP0002932_abnormal_joint_morphology1.16490088
52MP0003195_calcinosis1.11690621
53MP0009053_abnormal_anal_canal1.09493312
54MP0005408_hypopigmentation1.08987897
55MP0000750_abnormal_muscle_regeneration1.08696753
56MP0000163_abnormal_cartilage_morphology1.08246877
57MP0002282_abnormal_trachea_morphology1.06034482
58MP0003942_abnormal_urinary_system1.04985752
59MP0003115_abnormal_respiratory_system1.00564068
60MP0010368_abnormal_lymphatic_system0.96525686
61MP0003755_abnormal_palate_morphology0.96034139
62MP0005084_abnormal_gallbladder_morpholo0.96029687
63MP0009840_abnormal_foam_cell0.95459228
64MP0002115_abnormal_skeleton_extremities0.95061875
65MP0003329_amyloid_beta_deposits0.94802334
66MP0008875_abnormal_xenobiotic_pharmacok0.92934815
67MP0005220_abnormal_exocrine_pancreas0.92243777
68MP0001270_distended_abdomen0.91845523
69MP0008260_abnormal_autophagy0.91563188
70MP0004233_abnormal_muscle_weight0.91340965
71MP0002113_abnormal_skeleton_development0.90284649
72MP0001177_atelectasis0.88186490
73MP0002168_other_aberrant_phenotype0.86253711
74MP0000428_abnormal_craniofacial_morphol0.85484426
75MP0000003_abnormal_adipose_tissue0.85072744
76MP0000759_abnormal_skeletal_muscle0.81380505
77MP0001533_abnormal_skeleton_physiology0.81237241
78MP0005595_abnormal_vascular_smooth0.78486900
79MP0002128_abnormal_blood_circulation0.78200994
80MP0005410_abnormal_fertilization0.77851581
81MP0001849_ear_inflammation0.77837394
82MP0000639_abnormal_adrenal_gland0.77713642
83MP0003121_genomic_imprinting0.77263913
84MP0002133_abnormal_respiratory_system0.76958779
85MP0005388_respiratory_system_phenotype0.76958779
86MP0001614_abnormal_blood_vessel0.76883339
87MP0000049_abnormal_middle_ear0.76119039
88MP0002998_abnormal_bone_remodeling0.75713126
89MP0002269_muscular_atrophy0.74735741
90MP0002233_abnormal_nose_morphology0.73903894
91MP0005171_absent_coat_pigmentation0.73360082
92MP0000762_abnormal_tongue_morphology0.73271669
93MP0000604_amyloidosis0.72331150
94MP0002092_abnormal_eye_morphology0.72304135
95MP0008004_abnormal_stomach_pH0.71321155
96MP0000751_myopathy0.71198191
97MP0000858_altered_metastatic_potential0.70703808
98MP0003868_abnormal_feces_composition0.70079860
99MP0000534_abnormal_ureter_morphology0.69051250
100MP0003045_fibrosis0.68067889
101MP0003795_abnormal_bone_structure0.66340326
102MP0000432_abnormal_head_morphology0.66293118
103MP0003879_abnormal_hair_cell0.66111506
104MP0002089_abnormal_postnatal_growth/wei0.65632503
105MP0001175_abnormal_lung_morphology0.65044062
106MP0005375_adipose_tissue_phenotype0.64824829
107MP0005369_muscle_phenotype0.64023571
108MP0001915_intracranial_hemorrhage0.63924336
109MP0002111_abnormal_tail_morphology0.63853363
110MP0003252_abnormal_bile_duct0.63143456
111MP0003941_abnormal_skin_development0.62912603
112MP0000747_muscle_weakness0.62419026
113MP0002116_abnormal_craniofacial_bone0.62356563
114MP0002177_abnormal_outer_ear0.61728526
115MP0002109_abnormal_limb_morphology0.60791581
116MP0010630_abnormal_cardiac_muscle0.60609781
117MP0005330_cardiomyopathy0.60444727
118MP0003937_abnormal_limbs/digits/tail_de0.60165764
119MP0002938_white_spotting0.60078318
120MP0010771_integument_phenotype0.59600812
121MP0000537_abnormal_urethra_morphology0.59401712
122MP0003950_abnormal_plasma_membrane0.59356706
123MP0002249_abnormal_larynx_morphology0.58858849
124MP0005197_abnormal_uvea_morphology0.58559068
125MP0004087_abnormal_muscle_fiber0.57390953
126MP0002234_abnormal_pharynx_morphology0.57086464
127MP0002925_abnormal_cardiovascular_devel0.56843457
128MP0005076_abnormal_cell_differentiation0.56232499
129MP0005193_abnormal_anterior_eye0.55962779
130MP0000462_abnormal_digestive_system0.55710322
131MP0003935_abnormal_craniofacial_develop0.54648122
132MP0003448_altered_tumor_morphology0.52975702
133MP0002114_abnormal_axial_skeleton0.52598262
134MP0003300_gastrointestinal_ulcer0.52557742
135MP0000749_muscle_degeneration0.51500750
136MP0005164_abnormal_response_to0.50078835
137MP0005083_abnormal_biliary_tract0.50001198
138MP0005165_increased_susceptibility_to0.49117834

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.90137833
2Premature rupture of membranes (HP:0001788)9.50178181
3Deep venous thrombosis (HP:0002625)6.63152190
4Peritonitis (HP:0002586)6.15705212
5Atrophic scars (HP:0001075)5.49304458
6Soft skin (HP:0000977)5.38148229
7Aortic dissection (HP:0002647)5.29974487
8Abnormality of dentin (HP:0010299)4.92755615
9Shallow orbits (HP:0000586)4.90863940
10Bladder diverticulum (HP:0000015)4.85366293
11Small epiphyses (HP:0010585)4.78947296
12Fragile skin (HP:0001030)4.73754467
13Aortic aneurysm (HP:0004942)4.66215811
14Dilatation of the ascending aorta (HP:0005111)4.63512109
15Biconcave vertebral bodies (HP:0004586)4.31596985
16Genu recurvatum (HP:0002816)4.26512883
17Vertebral compression fractures (HP:0002953)4.20382117
18Wormian bones (HP:0002645)4.12734591
19Ankle contracture (HP:0006466)4.00818392
20Prolonged partial thromboplastin time (HP:0003645)3.96042418
21Bowel diverticulosis (HP:0005222)3.87020919
22Blue sclerae (HP:0000592)3.74842097
23Vascular tortuosity (HP:0004948)3.73355076
24Neonatal short-limb short stature (HP:0008921)3.70730188
25Cerebral aneurysm (HP:0004944)3.64904916
26Wrist flexion contracture (HP:0001239)3.59389857
27Abnormality of carpal bone ossification (HP:0006257)3.48217001
28Broad metatarsal (HP:0001783)3.45907943
29Infantile muscular hypotonia (HP:0008947)3.41157737
30Joint hemorrhage (HP:0005261)3.39052888
31Epiphyseal dysplasia (HP:0002656)3.39008535
32Overgrowth (HP:0001548)3.37659930
33Arterial tortuosity (HP:0005116)3.32392261
34Spinal rigidity (HP:0003306)3.27670799
35Mitral valve prolapse (HP:0001634)3.23864124
36Cervical subluxation (HP:0003308)3.17269163
37Renal duplication (HP:0000075)3.17063182
38Type 1 muscle fiber predominance (HP:0003803)3.15805574
39Abnormal delivery (HP:0001787)3.15551646
40Complement deficiency (HP:0004431)3.15214660
41Abnormality of the common coagulation pathway (HP:0010990)3.10836680
42Hypoplasia of the capital femoral epiphysis (HP:0003090)3.05458021
43Hyperextensible skin (HP:0000974)3.01975323
44Asymmetry of the thorax (HP:0001555)2.99933104
45Abnormality of the acetabulum (HP:0003170)2.99775726
46Increased connective tissue (HP:0009025)2.98900870
47Mitral stenosis (HP:0001718)2.94744939
48Hemorrhage of the eye (HP:0011885)2.88198935
49Follicular hyperkeratosis (HP:0007502)2.85435323
50Abnormal ossification of hand bones (HP:0005921)2.84585011
51Irregular epiphyses (HP:0010582)2.84156506
52Joint stiffness (HP:0001387)2.82681344
53Ectopia lentis (HP:0001083)2.78475464
54Hypercholesterolemia (HP:0003124)2.78456792
55Flat acetabular roof (HP:0003180)2.75686305
56Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.75098177
57Absent epiphyses (HP:0010577)2.75098177
58Congenital glaucoma (HP:0001087)2.74153265
59Hypobetalipoproteinemia (HP:0003563)2.73755115
60Breech presentation (HP:0001623)2.72970730
61Abnormality of the peritoneum (HP:0002585)2.67362659
62Coxa vara (HP:0002812)2.66507351
63Broad palm (HP:0001169)2.65550418
64Abnormality of complement system (HP:0005339)2.63143003
65Abnormal hand bone ossification (HP:0010660)2.59734978
66Cardiovascular calcification (HP:0011915)2.52743963
67Distal upper limb amyotrophy (HP:0007149)2.52565487
68Upper limb amyotrophy (HP:0009129)2.52565487
69Deviation of the hallux (HP:0010051)2.52465952
70Mildly elevated creatine phosphokinase (HP:0008180)2.51051079
71Aneurysm (HP:0002617)2.49717712
72Flared iliac wings (HP:0002869)2.47788608
73Round ear (HP:0100830)2.47292384
74Glomerulonephritis (HP:0000099)2.46327591
75Difficulty climbing stairs (HP:0003551)2.45704190
76Hallux valgus (HP:0001822)2.45535915
77Cupped ribs (HP:0000887)2.43950348
78Abnormal tarsal ossification (HP:0008369)2.42635252
79Xanthomatosis (HP:0000991)2.41082956
80Short nail (HP:0001799)2.40539624
81Nonimmune hydrops fetalis (HP:0001790)2.36706422
82Ovoid vertebral bodies (HP:0003300)2.34886851
83Menorrhagia (HP:0000132)2.32370289
84Increased variability in muscle fiber diameter (HP:0003557)2.25457874
85Buphthalmos (HP:0000557)2.24630175
86Thin bony cortex (HP:0002753)2.24022315
87Joint laxity (HP:0001388)2.21316553
88* Elbow flexion contracture (HP:0002987)2.21235151
89Camptodactyly of toe (HP:0001836)2.20376276
90Renovascular hypertension (HP:0100817)2.17948271
91Abnormality of the Achilles tendon (HP:0005109)2.16620735
92Slender build (HP:0001533)2.15044940
93Vascular calcification (HP:0004934)2.13955174
94Hypolipoproteinemia (HP:0010981)2.13675215
95Ulnar deviation of the wrist (HP:0003049)2.12522545
96Wide anterior fontanel (HP:0000260)2.11025690
97Mitral regurgitation (HP:0001653)2.09022549
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04998736
99Hand muscle atrophy (HP:0009130)2.03439575
100Beaking of vertebral bodies (HP:0004568)2.01179339
101Pterygium (HP:0001059)2.00488092
102Osteoarthritis (HP:0002758)1.99043413
103Back pain (HP:0003418)1.98632348
104Tibial bowing (HP:0002982)1.97614554
105Vaginal fistula (HP:0004320)1.96996066
106Premature skin wrinkling (HP:0100678)1.96689644
107Venous abnormality (HP:0002624)1.96639286
108Abnormality of skeletal muscle fiber size (HP:0012084)1.96578980
109Spondylolisthesis (HP:0003302)1.96126901
110Hyperacusis (HP:0010780)1.95497947
111Abnormality of the calcaneus (HP:0008364)1.95468010
112Decreased subcutaneous fat (HP:0001002)1.93419484
113Femoral bowing (HP:0002980)1.92032591
114Broad ribs (HP:0000885)1.91708774
115Achilles tendon contracture (HP:0001771)1.91172312
116Acanthocytosis (HP:0001927)1.91145164
117Disproportionate tall stature (HP:0001519)1.91129726
118Delayed closure of the anterior fontanelle (HP:0001476)1.89081986
119Abnormality of the wing of the ilium (HP:0011867)1.88316399
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.87633479
121Osteolytic defects of the hand bones (HP:0009699)1.87633479
122Spinal cord compression (HP:0002176)1.86880310
123Dislocated radial head (HP:0003083)1.86704872
124Venous insufficiency (HP:0005293)1.86645833
125Distal lower limb amyotrophy (HP:0008944)1.86314964
126Increased density of long bones (HP:0006392)1.86167073
127Abnormality of the lumbar spine (HP:0100712)1.85642601
128Thin skin (HP:0000963)1.85585807
129Mild short stature (HP:0003502)1.85146409
130Decreased skull ossification (HP:0004331)1.84953048
131Skin nodule (HP:0200036)1.84091466
132Impaired pain sensation (HP:0007328)1.84064113
133Abnormality of pain sensation (HP:0010832)1.84064113
134Abnormality of the anterior chamber (HP:0000593)1.83663216
135Mesomelia (HP:0003027)1.83021926
136Arnold-Chiari malformation (HP:0002308)1.81097353
137Broad alveolar ridges (HP:0000187)1.81076141
138Morphological abnormality of the middle ear (HP:0008609)1.80738651
139Lumbar hyperlordosis (HP:0002938)1.80329165
140Protruding ear (HP:0000411)1.79117864
141Systemic lupus erythematosus (HP:0002725)1.77331452
142Scapular winging (HP:0003691)1.76156782
143Ulnar bowing (HP:0003031)1.75870624
144Abnormality of skull ossification (HP:0002703)1.74817708
145Osteopenia (HP:0000938)1.74766468
146Platyspondyly (HP:0000926)1.74261552
147Calcaneovalgus deformity (HP:0001848)1.72404613
148Coronal craniosynostosis (HP:0004440)1.72299874
149Inguinal hernia (HP:0000023)1.72188848
150Generalized amyotrophy (HP:0003700)1.71550768
151Knee flexion contracture (HP:0006380)1.70884696
152Joint contractures involving the joints of the feet (HP:0100492)1.70111972
153Flexion contracture of toe (HP:0005830)1.70111972
154Broad long bones (HP:0005622)1.69976525
155Radial bowing (HP:0002986)1.69114080
156Bradycardia (HP:0001662)1.68802928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.13280504
2LATS24.95744950
3TRIB34.38205669
4ERN13.85551511
5DDR23.72700076
6TTN3.69358669
7ICK3.57712581
8FGFR33.29116645
9PKN23.03958300
10PDGFRA2.91553357
11TESK12.44649419
12TYRO32.44297882
13WNK42.28017863
14LATS12.26019181
15EPHA22.23307142
16PAK22.21915018
17PTK22.02074448
18MOS1.96614118
19RPS6KA41.82417568
20EPHB21.78029837
21PAK31.77869942
22PIM21.76426258
23BMX1.72948160
24PTK2B1.66066032
25WNK11.63982667
26FER1.62414229
27LIMK11.60854231
28PIK3CG1.56580679
29EPHA31.41077117
30LRRK21.40469522
31TRPM71.34602563
32MAP2K11.32937470
33PAK41.30228416
34TAOK21.28597115
35NME21.27749061
36RIPK11.25486391
37SMG11.25249782
38IRAK31.24481956
39MAPKAPK31.21518125
40AKT31.18055543
41TESK21.15081878
42MUSK1.12494997
43MAP3K31.08226930
44TAOK11.06628348
45PTK61.04830922
46ILK0.99454071
47FGFR20.98999863
48PDPK10.95838257
49EEF2K0.94802265
50DMPK0.94558842
51MST1R0.94341416
52FGFR10.92067064
53PRKD30.90619433
54NTRK10.90360440
55PAK10.88889009
56MTOR0.86060423
57MAPK110.85847056
58ARAF0.85130300
59PDGFRB0.85005955
60MET0.84509301
61SIK10.83160571
62SCYL20.83135763
63MYLK0.83077563
64MAP3K80.80916349
65ABL20.77386823
66SIK20.77286182
67NEK90.75335283
68CAMKK10.73890735
69ROCK10.73834232
70SGK2230.73629400
71SGK4940.73629400
72BRSK10.73491612
73CDK150.72802270
74STK30.72406017
75CDK70.72343549
76ERBB30.72033066
77EPHA40.70928974
78CDK140.69874560
79MAP3K100.69038659
80DAPK30.68085679
81FLT30.67979512
82PRKD10.66492476
83KSR20.66307782
84CDK180.65970060
85CDK11A0.65851550
86CDC42BPA0.63527991
87CDK60.62848858
88EIF2AK10.61816595
89EPHB10.61661025
90PRKD20.60810829
91PAK60.59313615
92INSR0.59001767
93SGK30.58861065
94MAP3K110.58267802
95RET0.58238102
96MAP2K30.56568937
97NEK20.55018966
98RPS6KA20.54483368
99PIK3CA0.53913601
100MAP3K60.53908144
101ROCK20.52538550
102PLK20.51646199
103CAMK1G0.50580496
104CLK10.48310101
105RPS6KB20.47814441
106MAP3K70.47536050
107PRKAA20.47375749
108RPS6KB10.46493912
109PDK20.46040239
110STK38L0.45519572
111PDK10.43721644
112MELK0.42674866
113MAP3K10.41423005
114STK100.40237382
115ERBB20.39238094
116CDK80.38854639
117MARK20.38768085
118CSNK1E0.38601896
119MAP2K20.38293642
120PRPF4B0.35173399
121ERBB40.35158275
122PRKG20.34554318
123BRD40.34252281
124CDK120.34067584
125DYRK1B0.33794812
126MAP3K20.32894217
127MAPKAPK50.32378261
128SRC0.32011932
129SGK10.31960064
130KSR10.31421672
131CAMKK20.31174637
132PBK0.29829725
133PRKAA10.29814214
134TGFBR20.29490416
135SGK20.28953227
136MAPK100.28890339
137NTRK30.28570448
138STK380.27716310
139LMTK20.27470552
140MAPKAPK20.26519932
141BRAF0.26169945
142PRKCH0.24665884
143PDK30.24647134
144PDK40.24647134

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.41254853
2ECM-receptor interaction_Homo sapiens_hsa045124.33721025
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.86203395
4Focal adhesion_Homo sapiens_hsa045103.15756384
5Protein digestion and absorption_Homo sapiens_hsa049743.05187947
6Bladder cancer_Homo sapiens_hsa052192.91174565
7Other glycan degradation_Homo sapiens_hsa005112.48742678
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.46125945
9Proteoglycans in cancer_Homo sapiens_hsa052052.43868913
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41849558
11Adherens junction_Homo sapiens_hsa045202.25518333
12Malaria_Homo sapiens_hsa051442.24219332
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.18398756
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.17473738
15Fatty acid biosynthesis_Homo sapiens_hsa000612.12607049
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.08574875
17Amoebiasis_Homo sapiens_hsa051462.05493957
18Dilated cardiomyopathy_Homo sapiens_hsa054142.01160296
19Arginine biosynthesis_Homo sapiens_hsa002201.98862558
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.91109653
21TGF-beta signaling pathway_Homo sapiens_hsa043501.88070749
22Shigellosis_Homo sapiens_hsa051311.85107769
23p53 signaling pathway_Homo sapiens_hsa041151.80787479
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.80172973
25Hippo signaling pathway_Homo sapiens_hsa043901.78475140
26MicroRNAs in cancer_Homo sapiens_hsa052061.72538611
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65349668
28Vitamin B6 metabolism_Homo sapiens_hsa007501.64316877
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59908329
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.59597584
31Fat digestion and absorption_Homo sapiens_hsa049751.58946290
32Vitamin digestion and absorption_Homo sapiens_hsa049771.56473079
33Steroid biosynthesis_Homo sapiens_hsa001001.56124263
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.55447394
35Small cell lung cancer_Homo sapiens_hsa052221.52438960
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48929797
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48366208
38PPAR signaling pathway_Homo sapiens_hsa033201.46102005
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43017001
40Melanoma_Homo sapiens_hsa052181.42545412
41Chronic myeloid leukemia_Homo sapiens_hsa052201.41789409
42Biosynthesis of amino acids_Homo sapiens_hsa012301.31365074
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30897275
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24286723
45Fatty acid metabolism_Homo sapiens_hsa012121.22142506
46Phenylalanine metabolism_Homo sapiens_hsa003601.22039066
47Rap1 signaling pathway_Homo sapiens_hsa040151.15380924
48TNF signaling pathway_Homo sapiens_hsa046681.15379852
49Fatty acid degradation_Homo sapiens_hsa000711.15065893
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12255701
51Basal cell carcinoma_Homo sapiens_hsa052171.11841769
52Phagosome_Homo sapiens_hsa041451.11340101
53HIF-1 signaling pathway_Homo sapiens_hsa040661.10911134
54Histidine metabolism_Homo sapiens_hsa003401.09782119
55Glioma_Homo sapiens_hsa052141.08996914
56Fructose and mannose metabolism_Homo sapiens_hsa000511.07657417
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.07420360
58Tight junction_Homo sapiens_hsa045301.04039412
59Axon guidance_Homo sapiens_hsa043601.01148420
60Galactose metabolism_Homo sapiens_hsa000521.00584200
61Pancreatic secretion_Homo sapiens_hsa049721.00306407
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99315522
63Pancreatic cancer_Homo sapiens_hsa052120.98315767
64Lysine degradation_Homo sapiens_hsa003100.97232817
65N-Glycan biosynthesis_Homo sapiens_hsa005100.96039054
66Bile secretion_Homo sapiens_hsa049760.92225291
67Platelet activation_Homo sapiens_hsa046110.92036691
68VEGF signaling pathway_Homo sapiens_hsa043700.91473581
69HTLV-I infection_Homo sapiens_hsa051660.89502898
70Hedgehog signaling pathway_Homo sapiens_hsa043400.88847050
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.87837616
72Prostate cancer_Homo sapiens_hsa052150.85464655
73ABC transporters_Homo sapiens_hsa020100.85350675
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.84624688
75Wnt signaling pathway_Homo sapiens_hsa043100.82207740
76Vibrio cholerae infection_Homo sapiens_hsa051100.81355216
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79676190
78Pathways in cancer_Homo sapiens_hsa052000.79215820
79Gap junction_Homo sapiens_hsa045400.79050991
80Glucagon signaling pathway_Homo sapiens_hsa049220.78489560
81Apoptosis_Homo sapiens_hsa042100.78399841
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76996704
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76788968
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76721141
85Tyrosine metabolism_Homo sapiens_hsa003500.76541140
86Starch and sucrose metabolism_Homo sapiens_hsa005000.76100541
87Insulin resistance_Homo sapiens_hsa049310.75517658
88Salmonella infection_Homo sapiens_hsa051320.72168502
89GnRH signaling pathway_Homo sapiens_hsa049120.71730622
90Melanogenesis_Homo sapiens_hsa049160.68514966
91Estrogen signaling pathway_Homo sapiens_hsa049150.66666881
92Viral myocarditis_Homo sapiens_hsa054160.66244161
93Insulin signaling pathway_Homo sapiens_hsa049100.66085711
94Colorectal cancer_Homo sapiens_hsa052100.65994050
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65252282
96Renal cell carcinoma_Homo sapiens_hsa052110.65201974
97AMPK signaling pathway_Homo sapiens_hsa041520.64222931
98Viral carcinogenesis_Homo sapiens_hsa052030.63625709
99Sulfur relay system_Homo sapiens_hsa041220.62763086
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62143820
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.62117745
102Toxoplasmosis_Homo sapiens_hsa051450.60864304
103One carbon pool by folate_Homo sapiens_hsa006700.58039718
104Hepatitis B_Homo sapiens_hsa051610.57601407
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57474246
106Carbon metabolism_Homo sapiens_hsa012000.56237168
107Ras signaling pathway_Homo sapiens_hsa040140.56048979
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55583606
109Thyroid cancer_Homo sapiens_hsa052160.54613806
110Sphingolipid metabolism_Homo sapiens_hsa006000.54305953
111Mineral absorption_Homo sapiens_hsa049780.53087453
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.52589078
113Endometrial cancer_Homo sapiens_hsa052130.52200306
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.50700151
115ErbB signaling pathway_Homo sapiens_hsa040120.50010899
116Protein export_Homo sapiens_hsa030600.49761096
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49746686
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49690511
119Endocytosis_Homo sapiens_hsa041440.48091013
120Prion diseases_Homo sapiens_hsa050200.46915465
121Renin-angiotensin system_Homo sapiens_hsa046140.45640421
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.44810205
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.43430150
124mTOR signaling pathway_Homo sapiens_hsa041500.43112413
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42168734
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41874621
127Staphylococcus aureus infection_Homo sapiens_hsa051500.41333080
128MAPK signaling pathway_Homo sapiens_hsa040100.41241867
129Ovarian steroidogenesis_Homo sapiens_hsa049130.41229717
130Oxytocin signaling pathway_Homo sapiens_hsa049210.41034206
131Arginine and proline metabolism_Homo sapiens_hsa003300.40317753
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40273872
133Thyroid hormone synthesis_Homo sapiens_hsa049180.39604439
134Pentose phosphate pathway_Homo sapiens_hsa000300.39528190
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38064466
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37689158
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37543631
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37378299
139Rheumatoid arthritis_Homo sapiens_hsa053230.36104605
140Non-small cell lung cancer_Homo sapiens_hsa052230.35783849
141Choline metabolism in cancer_Homo sapiens_hsa052310.35602260
142FoxO signaling pathway_Homo sapiens_hsa040680.34038649
143Pertussis_Homo sapiens_hsa051330.30996426
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30785449
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27372940
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27200002
147Lysosome_Homo sapiens_hsa041420.26757957
148Glutathione metabolism_Homo sapiens_hsa004800.25701695

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