CRLF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.90366018
2proline biosynthetic process (GO:0006561)5.22497591
3replication fork processing (GO:0031297)5.11767114
4embryonic process involved in female pregnancy (GO:0060136)5.10050963
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.06107268
6negative regulation of cell killing (GO:0031342)5.06107268
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.74800656
8negative T cell selection (GO:0043383)4.64452426
9transcription from mitochondrial promoter (GO:0006390)4.56773568
10positive regulation of protein homooligomerization (GO:0032464)4.53857566
11negative thymic T cell selection (GO:0045060)4.49420939
12telomere maintenance via semi-conservative replication (GO:0032201)4.40852779
13cellular response to zinc ion (GO:0071294)4.17498809
14positive regulation of granulocyte differentiation (GO:0030854)4.12888366
15cellular response to interleukin-15 (GO:0071350)3.99859461
16response to interleukin-15 (GO:0070672)3.99493577
17somatic hypermutation of immunoglobulin genes (GO:0016446)3.89148592
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.89148592
19meiotic chromosome segregation (GO:0045132)3.82380630
20activated T cell proliferation (GO:0050798)3.80241227
21telomere maintenance via recombination (GO:0000722)3.79850315
22regulation of integrin activation (GO:0033623)3.79582112
23proline metabolic process (GO:0006560)3.73791892
24DNA strand elongation involved in DNA replication (GO:0006271)3.73786274
25nucleotide-excision repair, DNA gap filling (GO:0006297)3.73216866
26cellular extravasation (GO:0045123)3.68381360
27viral mRNA export from host cell nucleus (GO:0046784)3.67298197
28positive T cell selection (GO:0043368)3.62919211
29regulation of alpha-beta T cell proliferation (GO:0046640)3.61451766
30DNA strand elongation (GO:0022616)3.56283326
31DNA strand renaturation (GO:0000733)3.55048795
32positive regulation of alpha-beta T cell proliferation (GO:0046641)3.53739886
33poly(A)+ mRNA export from nucleus (GO:0016973)3.52811847
34negative regulation of T cell mediated immunity (GO:0002710)3.52698526
35regulation of regulatory T cell differentiation (GO:0045589)3.49361435
36positive regulation by symbiont of host defense response (GO:0052509)3.48589542
37modulation by symbiont of host defense response (GO:0052031)3.48589542
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48589542
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48589542
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.48589542
41modulation by symbiont of host immune response (GO:0052553)3.48589542
42B cell receptor signaling pathway (GO:0050853)3.48362789
43formation of translation preinitiation complex (GO:0001731)3.47167849
44interferon-gamma production (GO:0032609)3.46491617
45positive regulation of gamma-delta T cell activation (GO:0046645)3.44576742
46regulation of protein homooligomerization (GO:0032462)3.41689450
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.39785435
48mast cell activation (GO:0045576)3.39515491
49base-excision repair (GO:0006284)3.36623812
50neutrophil activation involved in immune response (GO:0002283)3.35522499
51mitotic G1 DNA damage checkpoint (GO:0031571)3.34557701
52mitochondrial DNA metabolic process (GO:0032042)3.34239104
53mitotic recombination (GO:0006312)3.33736985
54DNA topological change (GO:0006265)3.33398492
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.30392829
56tolerance induction (GO:0002507)3.29865295
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28221187
58mRNA cleavage (GO:0006379)3.27539177
59microglial cell activation (GO:0001774)3.27505820
60T cell selection (GO:0045058)3.25762337
61neutrophil activation (GO:0042119)3.23797665
62regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.22446108
63oxidative demethylation (GO:0070989)3.21467138
64positive thymic T cell selection (GO:0045059)3.20679300
65leukocyte aggregation (GO:0070486)3.16726043
66telomere maintenance via telomere lengthening (GO:0010833)3.15238991
67neural tube formation (GO:0001841)3.14077288
68detection of other organism (GO:0098543)3.13314864
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11729543
70regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.09769981
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07061222
72mast cell activation involved in immune response (GO:0002279)3.06786816
73mast cell degranulation (GO:0043303)3.06786816
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04587877
75kinetochore assembly (GO:0051382)3.02577080
76neutrophil mediated immunity (GO:0002446)3.01026450
77dosage compensation (GO:0007549)2.99205308
78regulation of double-strand break repair via homologous recombination (GO:0010569)2.98581636
79negative regulation of T-helper cell differentiation (GO:0045623)2.97557293
80negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97557293
81kinetochore organization (GO:0051383)2.97315307
82G1 DNA damage checkpoint (GO:0044783)2.97268437
83DNA ligation (GO:0006266)2.96932153
84regulation of interferon-beta biosynthetic process (GO:0045357)2.96632191
85negative regulation of RNA splicing (GO:0033119)2.96609420
86positive regulation of protein oligomerization (GO:0032461)2.96470532
87termination of RNA polymerase II transcription (GO:0006369)2.95496732
88respiratory burst (GO:0045730)2.94569624
89regulation of T cell mediated cytotoxicity (GO:0001914)2.94510491
90detection of bacterium (GO:0016045)2.93083071
91DNA integration (GO:0015074)2.92982255
92leukocyte degranulation (GO:0043299)2.92964226
93negative regulation of mRNA processing (GO:0050686)2.92493565
94mitotic G1/S transition checkpoint (GO:0044819)2.90523762
95positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90341082
96viral transcription (GO:0019083)2.89147182
97positive regulation of developmental pigmentation (GO:0048087)2.88356891
98double-strand break repair via nonhomologous end joining (GO:0006303)2.87993078
99non-recombinational repair (GO:0000726)2.87993078
100negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87003756
101myeloid cell activation involved in immune response (GO:0002275)2.86608137
102antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.85853316
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85853316
104positive regulation by host of viral transcription (GO:0043923)2.85034367
105regulation of T cell tolerance induction (GO:0002664)2.84704919
106negative regulation of interleukin-12 production (GO:0032695)2.83383677
107maturation of 5.8S rRNA (GO:0000460)2.83091628
108antigen receptor-mediated signaling pathway (GO:0050851)2.81579519
109hepatocyte apoptotic process (GO:0097284)2.81093628
110regulation of B cell receptor signaling pathway (GO:0050855)2.80070679
111histone mRNA catabolic process (GO:0071044)2.78376469
112thymic T cell selection (GO:0045061)2.77064850
113ribosomal small subunit assembly (GO:0000028)2.76568439
114regulation of memory T cell differentiation (GO:0043380)2.76285170
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75835780
116DNA double-strand break processing (GO:0000729)2.75770120
117positive regulation of DNA recombination (GO:0045911)2.75054622
118regulation of granulocyte differentiation (GO:0030852)2.74246601
119myeloid leukocyte mediated immunity (GO:0002444)2.72642500
120granulocyte activation (GO:0036230)2.72390377
121translational termination (GO:0006415)2.71811275
122regulation of isotype switching to IgG isotypes (GO:0048302)2.71777470
123negative regulation of adaptive immune response (GO:0002820)2.71554427
124establishment of apical/basal cell polarity (GO:0035089)2.70927359
125somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.70205206
126somatic cell DNA recombination (GO:0016444)2.70205206
127V(D)J recombination (GO:0033151)2.70130642
128regulation of natural killer cell mediated immunity (GO:0002715)2.70096084
129regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.70096084
130macrophage activation involved in immune response (GO:0002281)2.69197952
131negative regulation of leukocyte mediated immunity (GO:0002704)2.68271772
132regulation of DNA damage checkpoint (GO:2000001)2.67686251
133negative regulation of cAMP-mediated signaling (GO:0043951)2.67142943
134detection of external biotic stimulus (GO:0098581)2.66445664
135dendritic cell migration (GO:0036336)2.66295840
136regulation of tolerance induction (GO:0002643)2.66229057
137alpha-beta T cell differentiation (GO:0046632)2.65416243
138antigen processing and presentation of endogenous antigen (GO:0019883)2.65132043
139regulation of leukocyte mediated cytotoxicity (GO:0001910)2.64986383
140T cell homeostasis (GO:0043029)2.64947214
141positive regulation of mast cell activation (GO:0033005)2.64822042
142regulation of B cell differentiation (GO:0045577)2.64785681
143alpha-beta T cell activation (GO:0046631)2.64629570
144defense response to protozoan (GO:0042832)2.64598097
145response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64231968
146response to host immune response (GO:0052572)2.64231968
147positive regulation of isotype switching (GO:0045830)2.63675880
148regulation of mast cell activation (GO:0033003)2.62943602
149base-excision repair, AP site formation (GO:0006285)2.62673963
150positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.62497891
151positive regulation of B cell differentiation (GO:0045579)2.62233478
152DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.61677106
153mitochondrial RNA metabolic process (GO:0000959)2.61648822
154definitive hemopoiesis (GO:0060216)2.61216978
155DNA replication initiation (GO:0006270)2.60845488
156positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60736933
157positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.60129187
158positive regulation of mitotic sister chromatid separation (GO:1901970)2.60129187
159positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.60129187
160spliceosomal tri-snRNP complex assembly (GO:0000244)2.59966771
161histone H4-K12 acetylation (GO:0043983)2.58804522
162positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57813962
163detection of molecule of bacterial origin (GO:0032490)2.57736471
164T cell proliferation (GO:0042098)2.56980696
165negative regulation of stress fiber assembly (GO:0051497)2.56696836
166B cell mediated immunity (GO:0019724)2.56250236
167regulation of double-strand break repair (GO:2000779)2.55045467
168immunoglobulin mediated immune response (GO:0016064)2.54971583
169regulation of gamma-delta T cell differentiation (GO:0045586)2.54907764
170determination of adult lifespan (GO:0008340)2.54656731
171negative regulation of cell cycle arrest (GO:0071157)2.53921200
172mismatch repair (GO:0006298)2.53482340
173somatic diversification of immune receptors (GO:0002200)2.52878796
174embryonic placenta development (GO:0001892)2.50681127
175translational initiation (GO:0006413)2.50169621
176T cell migration (GO:0072678)2.48160701
177regulation of sister chromatid cohesion (GO:0007063)2.46563029
178translational elongation (GO:0006414)2.45889411
179regulation of gamma-delta T cell activation (GO:0046643)2.45229528
180regulation of protein oligomerization (GO:0032459)2.45139431
181telomere maintenance (GO:0000723)2.45012329
182regulation of translational fidelity (GO:0006450)2.44918464
183NIK/NF-kappaB signaling (GO:0038061)2.44664946
184telomere organization (GO:0032200)2.43282630
185negative regulation of JAK-STAT cascade (GO:0046426)2.42528982

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.89174324
2MYC_18555785_ChIP-Seq_MESCs_Mouse2.94186407
3VDR_21846776_ChIP-Seq_THP-1_Human2.78433766
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.75811973
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72961810
6RUNX_20019798_ChIP-Seq_JUKART_Human2.65861417
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.62458653
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49075400
9MYC_22102868_ChIP-Seq_BL_Human2.48772535
10ZNF274_21170338_ChIP-Seq_K562_Hela2.45377370
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38830329
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35854134
13GATA1_22025678_ChIP-Seq_K562_Human2.35647881
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25461430
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17807598
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17189647
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15251185
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12417112
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.10456489
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09461820
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.05455110
22* GATA3_26560356_Chip-Seq_TH2_Human2.04220818
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01170032
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00037025
25GATA3_27048872_Chip-Seq_THYMUS_Human1.94812812
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.93160652
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.92016897
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91660217
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91488060
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91442752
31IGF1R_20145208_ChIP-Seq_DFB_Human1.91049982
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.87727679
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80329878
34VDR_22108803_ChIP-Seq_LS180_Human1.80184357
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78056072
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76468145
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75356411
38SPI1_23547873_ChIP-Seq_NB4_Human1.74121837
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.73270484
40MAF_26560356_Chip-Seq_TH1_Human1.72990500
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71084309
42SCL_19346495_ChIP-Seq_HPC-7_Human1.63515571
43* VDR_23849224_ChIP-Seq_CD4+_Human1.62633100
44* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62232626
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59653615
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59455622
47* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.59446269
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58333840
49* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.56951859
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.55912602
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.55139033
52MYB_26560356_Chip-Seq_TH1_Human1.54149395
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52399725
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52399725
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52399725
56* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51285865
57UTX_26944678_Chip-Seq_JUKART_Human1.50854590
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50103783
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49942404
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.48997459
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48479870
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.48257342
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48202118
64VDR_24763502_ChIP-Seq_THP-1_Human1.47435266
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47128726
66MYB_26560356_Chip-Seq_TH2_Human1.47036756
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.45613112
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42769293
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.40325494
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40280827
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.39476688
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38654112
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38453088
74FOXP3_21729870_ChIP-Seq_TREG_Human1.37892858
75* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37354580
76ER_23166858_ChIP-Seq_MCF-7_Human1.37299295
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37163787
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36642008
79CIITA_25753668_ChIP-Seq_RAJI_Human1.35261839
80TAF15_26573619_Chip-Seq_HEK293_Human1.35174316
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33455482
82XRN2_22483619_ChIP-Seq_HELA_Human1.33440999
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33221278
84EWS_26573619_Chip-Seq_HEK293_Human1.32533043
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30946964
86SPI1_23127762_ChIP-Seq_K562_Human1.30862542
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30044787
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29886841
89MAF_26560356_Chip-Seq_TH2_Human1.29560386
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29448863
91GABP_19822575_ChIP-Seq_HepG2_Human1.29185169
92DCP1A_22483619_ChIP-Seq_HELA_Human1.28848609
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27348067
94ELK1_19687146_ChIP-ChIP_HELA_Human1.25783041
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24583664
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24551198
97TCF7_22412390_ChIP-Seq_EML_Mouse1.24493212
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.23810901
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22775819
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22292311
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21711616
102TTF2_22483619_ChIP-Seq_HELA_Human1.21670073
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21646667
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21340612
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20946122
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20048624
107* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19600314
108BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19267384
109* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18975407
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18654820
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18206423
112IRF1_19129219_ChIP-ChIP_H3396_Human1.17516032
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17034975
114KDM5A_27292631_Chip-Seq_BREAST_Human1.16089932
115TFEB_21752829_ChIP-Seq_HELA_Human1.15830194
116* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15564045
117SMRT_27268052_Chip-Seq_Bcells_Human1.14400353
118FUS_26573619_Chip-Seq_HEK293_Human1.13732198
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12901920
120* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12701377
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11786695
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11407636
123VDR_24787735_ChIP-Seq_THP-1_Human1.11211575
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11040099
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09900054
126GATA3_26560356_Chip-Seq_TH1_Human1.09310244
127* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08822828
128ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08333245
129* IRF8_27001747_Chip-Seq_BMDM_Mouse1.06892960
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.06257131
131TP63_19390658_ChIP-ChIP_HaCaT_Human1.05999210
132SRF_21415370_ChIP-Seq_HL-1_Mouse1.05409394
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05220192
134NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04618932
135NFE2_27457419_Chip-Seq_LIVER_Mouse1.03626084
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03318766
137* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02570472
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02490899
139TP53_22573176_ChIP-Seq_HFKS_Human1.02306192
140FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01632234
141KDM2B_26808549_Chip-Seq_DND41_Human1.00487397
142NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99950450
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.99491843
144VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99442987
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99023703
146ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98973303
147TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97637990
148FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95689982
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95417439
150P300_19829295_ChIP-Seq_ESCs_Human0.94242859
151GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93416140
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92023942
153* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91489853
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90980247
155BCAT_22108803_ChIP-Seq_LS180_Human0.90935626
156PU_27001747_Chip-Seq_BMDM_Mouse0.90243171
157FLI1_21867929_ChIP-Seq_TH2_Mouse0.89687618
158PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89642752
159MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89441407
160CRX_20693478_ChIP-Seq_RETINA_Mouse0.88891943
161GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88332064
162CBP_20019798_ChIP-Seq_JUKART_Human0.86995756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.75513046
2MP0009278_abnormal_bone_marrow3.13212285
3MP0000685_abnormal_immune_system3.03605779
4MP0010094_abnormal_chromosome_stability2.92046810
5MP0002396_abnormal_hematopoietic_system2.80286622
6MP0000569_abnormal_digit_pigmentation2.64724902
7MP0001835_abnormal_antigen_presentation2.61770286
8MP0005397_hematopoietic_system_phenotyp2.58230597
9MP0001545_abnormal_hematopoietic_system2.58230597
10MP0003763_abnormal_thymus_physiology2.57993204
11MP0008058_abnormal_DNA_repair2.53321675
12MP0005174_abnormal_tail_pigmentation2.48191752
13MP0003111_abnormal_nucleus_morphology2.21831473
14MP0000490_abnormal_crypts_of2.21702948
15MP0001800_abnormal_humoral_immune2.20936424
16MP0005671_abnormal_response_to2.19699651
17MP0002398_abnormal_bone_marrow2.15155384
18MP0003693_abnormal_embryo_hatching2.09983020
19MP0003077_abnormal_cell_cycle2.08807912
20MP0002009_preneoplasia2.04176574
21MP0005075_abnormal_melanosome_morpholog2.00174386
22MP0000689_abnormal_spleen_morphology1.99489143
23MP0004957_abnormal_blastocyst_morpholog1.99421493
24MP0002405_respiratory_system_inflammati1.95318819
25MP0009333_abnormal_splenocyte_physiolog1.94563549
26MP0002452_abnormal_antigen_presenting1.90424689
27MP0003786_premature_aging1.85004447
28MP0005171_absent_coat_pigmentation1.84973298
29MP0001790_abnormal_immune_system1.82707371
30MP0005387_immune_system_phenotype1.82707371
31MP0002723_abnormal_immune_serum1.82703862
32MP0002420_abnormal_adaptive_immunity1.82100943
33MP0008995_early_reproductive_senescence1.81435488
34MP0002722_abnormal_immune_system1.81224553
35MP0001819_abnormal_immune_cell1.80567014
36MP0003787_abnormal_imprinting1.80509006
37MP0009785_altered_susceptibility_to1.76916178
38MP0000716_abnormal_immune_system1.75835764
39MP0002166_altered_tumor_susceptibility1.75805240
40MP0005025_abnormal_response_to1.69995934
41MP0005000_abnormal_immune_tolerance1.69028653
42MP0006082_CNS_inflammation1.68928934
43MP0005464_abnormal_platelet_physiology1.66300921
44MP0002006_tumorigenesis1.63437592
45MP0000703_abnormal_thymus_morphology1.62032838
46MP0004808_abnormal_hematopoietic_stem1.60369984
47MP0002429_abnormal_blood_cell1.59722851
48MP0000015_abnormal_ear_pigmentation1.59235879
49MP0010155_abnormal_intestine_physiology1.57835371
50MP0004381_abnormal_hair_follicle1.55336558
51MP0005310_abnormal_salivary_gland1.54905830
52MP0010352_gastrointestinal_tract_polyps1.49962698
53MP0002019_abnormal_tumor_incidence1.48316105
54MP0003436_decreased_susceptibility_to1.48000844
55MP0001873_stomach_inflammation1.47789314
56MP0002148_abnormal_hypersensitivity_rea1.46996440
57MP0001986_abnormal_taste_sensitivity1.44857166
58MP0008877_abnormal_DNA_methylation1.41234437
59MP0009764_decreased_sensitivity_to1.34356683
60MP0002277_abnormal_respiratory_mucosa1.34232525
61MP0001853_heart_inflammation1.33608665
62MP0002419_abnormal_innate_immunity1.32629664
63MP0008007_abnormal_cellular_replicative1.28695327
64MP0003866_abnormal_defecation1.20887151
65MP0000350_abnormal_cell_proliferation1.17768980
66MP0008932_abnormal_embryonic_tissue1.17510663
67MP0010307_abnormal_tumor_latency1.14340270
68MP0003172_abnormal_lysosome_physiology1.14212260
69MP0003453_abnormal_keratinocyte_physiol1.13688300
70MP0000313_abnormal_cell_death1.13613706
71MP0000465_gastrointestinal_hemorrhage1.12363787
72MP0000371_diluted_coat_color1.10295149
73MP0002086_abnormal_extraembryonic_tissu1.04874580
74MP0008469_abnormal_protein_level1.03343203
75MP0002138_abnormal_hepatobiliary_system1.02868449
76MP0003828_pulmonary_edema1.02803593
77MP0001845_abnormal_inflammatory_respons1.02507630
78MP0005058_abnormal_lysosome_morphology1.01932263
79MP0002132_abnormal_respiratory_system1.01639568
80MP0001533_abnormal_skeleton_physiology1.01237388
81MP0010030_abnormal_orbit_morphology1.01107185
82MP0004147_increased_porphyrin_level1.00341756
83MP0002102_abnormal_ear_morphology0.97798744
84MP0005645_abnormal_hypothalamus_physiol0.97274819
85MP0003656_abnormal_erythrocyte_physiolo0.96969313
86MP0003646_muscle_fatigue0.96658259
87MP0001697_abnormal_embryo_size0.95218757
88MP0003195_calcinosis0.94908438
89MP0005076_abnormal_cell_differentiation0.94452680
90MP0003567_abnormal_fetal_cardiomyocyte0.94440322
91MP0002163_abnormal_gland_morphology0.93588729
92MP0003724_increased_susceptibility_to0.91653658
93MP0003303_peritoneal_inflammation0.90808947
94MP0000372_irregular_coat_pigmentation0.89787855
95MP0002928_abnormal_bile_duct0.89418964
96MP0002075_abnormal_coat/hair_pigmentati0.88623538
97MP0004947_skin_inflammation0.87179760
98MP0000470_abnormal_stomach_morphology0.87158794
99MP0000427_abnormal_hair_cycle0.86209567
100MP0001293_anophthalmia0.85251770
101MP0004883_abnormal_blood_vessel0.85025256
102MP0003252_abnormal_bile_duct0.84747998
103MP0001919_abnormal_reproductive_system0.84527665
104MP0002095_abnormal_skin_pigmentation0.83698256
105MP0003448_altered_tumor_morphology0.83602109
106MP0003183_abnormal_peptide_metabolism0.82527734
107MP0003045_fibrosis0.79164913
108MP0002693_abnormal_pancreas_physiology0.78055657
109MP0005083_abnormal_biliary_tract0.77149687
110MP0008872_abnormal_physiological_respon0.77106831
111MP0004484_altered_response_of0.76414140
112MP0004197_abnormal_fetal_growth/weight/0.76286286
113MP0003890_abnormal_embryonic-extraembry0.75904231
114MP0002084_abnormal_developmental_patter0.74760538
115MP0002080_prenatal_lethality0.74631756
116MP0001730_embryonic_growth_arrest0.74480561
117MP0005084_abnormal_gallbladder_morpholo0.73905066
118MP0003300_gastrointestinal_ulcer0.73824164
119MP0005380_embryogenesis_phenotype0.73692357
120MP0001672_abnormal_embryogenesis/_devel0.73692357
121MP0002085_abnormal_embryonic_tissue0.73631400
122MP0000858_altered_metastatic_potential0.73325183
123MP0008961_abnormal_basal_metabolism0.73131461
124MP0005551_abnormal_eye_electrophysiolog0.71629124
125MP0004133_heterotaxia0.71453069
126MP0001851_eye_inflammation0.70481943
127MP0000477_abnormal_intestine_morphology0.70214989
128MP0004142_abnormal_muscle_tone0.70168622
129MP0003943_abnormal_hepatobiliary_system0.69520863
130MP0001186_pigmentation_phenotype0.69021811
131MP0004130_abnormal_muscle_cell0.68111648
132MP0006072_abnormal_retinal_apoptosis0.67659645
133MP0004043_abnormal_pH_regulation0.67206082
134MP0002933_joint_inflammation0.64656951
135MP0004233_abnormal_muscle_weight0.63896680
136MP0001764_abnormal_homeostasis0.62756388
137MP0005253_abnormal_eye_physiology0.61896423
138MP0006035_abnormal_mitochondrial_morpho0.61642259
139MP0001663_abnormal_digestive_system0.61147446
140MP0009765_abnormal_xenobiotic_induced0.60661476
141MP0009763_increased_sensitivity_to0.60483866
142MP0005023_abnormal_wound_healing0.59374710

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.07299825
2Stomatitis (HP:0010280)4.88656534
3Poikiloderma (HP:0001029)4.68520593
4Increased IgM level (HP:0003496)4.25650645
5Severe combined immunodeficiency (HP:0004430)3.50169281
6Retrobulbar optic neuritis (HP:0100654)3.49402422
7Optic neuritis (HP:0100653)3.49402422
8IgM deficiency (HP:0002850)3.43828399
9Rib fusion (HP:0000902)3.30025531
10Facial hemangioma (HP:0000329)3.21030009
11IgG deficiency (HP:0004315)3.20617803
12IgA deficiency (HP:0002720)3.17912012
13Rectal fistula (HP:0100590)3.17910496
14Rectovaginal fistula (HP:0000143)3.17910496
15Basal cell carcinoma (HP:0002671)3.17091531
16Recurrent fungal infections (HP:0002841)3.16678453
17Encephalitis (HP:0002383)3.15520478
18Orchitis (HP:0100796)3.15175624
19Intestinal fistula (HP:0100819)3.15056364
20Albinism (HP:0001022)3.09968564
21Thyroiditis (HP:0100646)3.07478025
22Abnormality of T cell physiology (HP:0011840)3.07140614
23Abnormality of male internal genitalia (HP:0000022)3.00823997
24Squamous cell carcinoma (HP:0002860)2.98128890
25Stomach cancer (HP:0012126)2.96436820
26Acute lymphatic leukemia (HP:0006721)2.88759724
27Absent thumb (HP:0009777)2.88606254
28Recurrent skin infections (HP:0001581)2.88295475
29Hypochromic microcytic anemia (HP:0004840)2.88241061
30Elevated erythrocyte sedimentation rate (HP:0003565)2.88019075
31Abnormality of T cells (HP:0002843)2.87131764
32Recurrent abscess formation (HP:0002722)2.85428959
33Congenital stationary night blindness (HP:0007642)2.84222556
34Annular pancreas (HP:0001734)2.82356094
35Hypochromic anemia (HP:0001931)2.81251062
36Vaginal fistula (HP:0004320)2.78238657
37Concave nail (HP:0001598)2.78211639
38Gastrointestinal infarctions (HP:0005244)2.77104476
39Recurrent viral infections (HP:0004429)2.75908513
40Combined immunodeficiency (HP:0005387)2.74891760
41Leukocytosis (HP:0001974)2.71901404
42Panhypogammaglobulinemia (HP:0003139)2.71533413
43Recurrent bronchitis (HP:0002837)2.69823143
44Abnormality of eosinophils (HP:0001879)2.67772512
45Colitis (HP:0002583)2.67187091
46Prolonged bleeding time (HP:0003010)2.65748451
47Keratoconjunctivitis (HP:0001096)2.65426621
48Lymphoma (HP:0002665)2.65424752
49Autoimmune hemolytic anemia (HP:0001890)2.65237660
50Chronic otitis media (HP:0000389)2.62446380
51Premature graying of hair (HP:0002216)2.61499765
52Abnormality of cells of the erythroid lineage (HP:0012130)2.60391673
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60340986
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.60164353
55Keratoconjunctivitis sicca (HP:0001097)2.58087752
56Eosinophilia (HP:0001880)2.54741890
57Ulnar bowing (HP:0003031)2.54634843
58Myositis (HP:0100614)2.53458759
59Inflammation of the large intestine (HP:0002037)2.52842883
60Granulocytopenia (HP:0001913)2.52132113
61Abnormal number of erythroid precursors (HP:0012131)2.49505641
62Pancreatic cysts (HP:0001737)2.49294684
63Attenuation of retinal blood vessels (HP:0007843)2.45635253
64Gastrointestinal inflammation (HP:0004386)2.44874149
65Tongue fasciculations (HP:0001308)2.44601778
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.42726475
67Muscle fiber atrophy (HP:0100295)2.42283115
68Myelodysplasia (HP:0002863)2.41518725
69Cheilitis (HP:0100825)2.41419784
70Reticulocytopenia (HP:0001896)2.39207755
71Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37950092
72Patellar aplasia (HP:0006443)2.36016546
73Chest pain (HP:0100749)2.35467161
74Chromsome breakage (HP:0040012)2.35461719
75Abnormal rod and cone electroretinograms (HP:0008323)2.35118253
76Type 2 muscle fiber atrophy (HP:0003554)2.32983430
77Agammaglobulinemia (HP:0004432)2.32442525
78Mediastinal lymphadenopathy (HP:0100721)2.31500993
79Absent radius (HP:0003974)2.31320513
80Abnormality of macrophages (HP:0004311)2.31225367
81Petechiae (HP:0000967)2.30435314
82Volvulus (HP:0002580)2.28126802
83Eczematoid dermatitis (HP:0000976)2.27355308
84Spontaneous hematomas (HP:0007420)2.27039544
85Hemoptysis (HP:0002105)2.26915224
86Pulmonary infiltrates (HP:0002113)2.26744511
87T lymphocytopenia (HP:0005403)2.25710450
88Meningitis (HP:0001287)2.24762932
89Abnormality of the renal cortex (HP:0011035)2.23219216
90Prostate neoplasm (HP:0100787)2.22783059
91Selective tooth agenesis (HP:0001592)2.22760110
92Thrombocytosis (HP:0001894)2.22391469
93Intestinal atresia (HP:0011100)2.20005948
94Recurrent bacterial skin infections (HP:0005406)2.19784085
95Abnormality of T cell number (HP:0011839)2.15156345
96Aplasia involving forearm bones (HP:0009822)2.15090435
97Absent forearm bone (HP:0003953)2.15090435
98Orthostatic hypotension (HP:0001278)2.14314519
99Abnormality of cells of the lymphoid lineage (HP:0012140)2.12864951
100Alopecia of scalp (HP:0002293)2.12264723
101Aplasia/Hypoplasia of the patella (HP:0006498)2.11918680
102Pancreatic fibrosis (HP:0100732)2.11911004
103Abnormality of the ileum (HP:0001549)2.09895244
104Chronic diarrhea (HP:0002028)2.09232277
105Hypergammaglobulinemia (HP:0010702)2.09101884
106Lymphopenia (HP:0001888)2.08770785
107Muscle fibrillation (HP:0010546)2.06915386
108Cellulitis (HP:0100658)2.06655905
109Recurrent lower respiratory tract infections (HP:0002783)2.04490985
110Abnormal hemoglobin (HP:0011902)2.04173799
111Exertional dyspnea (HP:0002875)2.03902818
112Recurrent gram-negative bacterial infections (HP:0005420)2.03743185
113Renal cortical cysts (HP:0000803)2.03722256
114Abnormality of DNA repair (HP:0003254)2.02433598
115Obstructive lung disease (HP:0006536)2.02083002
116Chronic obstructive pulmonary disease (HP:0006510)2.02083002
117Capillary hemangiomas (HP:0005306)2.01365536
118Urticaria (HP:0001025)2.00572185
119Arterial thrombosis (HP:0004420)1.99883033
120Recurrent cutaneous fungal infections (HP:0011370)1.98960429
121Chronic mucocutaneous candidiasis (HP:0002728)1.98960429
122Recurrent sinusitis (HP:0011108)1.98374812
123Hypoproteinemia (HP:0003075)1.95301096
124Anorexia (HP:0002039)1.95251794
125Pulmonary fibrosis (HP:0002206)1.95151823
126Abnormality of midbrain morphology (HP:0002418)1.94052619
127Molar tooth sign on MRI (HP:0002419)1.94052619
128Nasal polyposis (HP:0100582)1.93801905
129Aplasia/hypoplasia of the humerus (HP:0006507)1.92435741
130Hypoplasia of the thymus (HP:0000778)1.92202122
131Abnormality of the fingertips (HP:0001211)1.91427737
132Abnormal platelet volume (HP:0011876)1.91357385
133Microcytic anemia (HP:0001935)1.91240254
134Vasculitis (HP:0002633)1.90001450
135Abnormal number of incisors (HP:0011064)1.89730828
136True hermaphroditism (HP:0010459)1.89688965
137Abnormality of the heme biosynthetic pathway (HP:0010472)1.88970394
138Abnormality of B cell number (HP:0010975)1.88744867
139B lymphocytopenia (HP:0010976)1.88744867
140Acute hepatic failure (HP:0006554)1.88358941
141Short humerus (HP:0005792)1.87736900
142Birth length less than 3rd percentile (HP:0003561)1.87681658
143Amaurosis fugax (HP:0100576)1.86853313
144Abnormality of the prostate (HP:0008775)1.86719584
145Gaze-evoked nystagmus (HP:0000640)1.84704086
146Decreased central vision (HP:0007663)1.83320059
147Hematochezia (HP:0002573)1.82514812
148Abolished electroretinogram (ERG) (HP:0000550)1.80830549
149Epistaxis (HP:0000421)1.79108082
150Constricted visual fields (HP:0001133)1.78380588
151Autoimmune thrombocytopenia (HP:0001973)1.77315816
152Pulmonary embolism (HP:0002204)1.76487231
153Gangrene (HP:0100758)1.76084266
154Neoplasm of the tracheobronchial system (HP:0100552)1.71525758
155Neutropenia (HP:0001875)1.71389981
156Gingival bleeding (HP:0000225)1.70467850
157Episodic fever (HP:0001954)1.69936824
158Aplasia/Hypoplasia of the thymus (HP:0010515)1.68904573
159Abnormality of the pleura (HP:0002103)1.68569260
160Keratitis (HP:0000491)1.66860718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.11687968
2ICK3.52399794
3MAP4K13.33759859
4MAPK153.13624752
5MAP3K63.05329807
6TAOK33.01028500
7RIPK42.86362152
8MATK2.76012594
9PIM22.49014781
10MAP3K112.47528412
11DDR22.40886522
12NUAK12.29101967
13CSK2.20413281
14FGR2.16305745
15PIM12.11957808
16CAMKK22.04543815
17TXK2.02387664
18FES2.01346161
19YES11.89402618
20PINK11.81785572
21PRKD21.72904554
22CDK71.71053903
23DAPK11.70979282
24MAP3K101.61484420
25BMPR1B1.57990094
26MAP4K21.55484983
27KIT1.51757850
28STK101.50535185
29BLK1.49049566
30TRPM71.48294213
31JAK31.45199524
32BMPR21.41528410
33WEE11.40712919
34DYRK1B1.40109354
35DYRK31.37433872
36NME21.34845314
37TYRO31.32810091
38BTK1.32497892
39ADRBK21.29463652
40IKBKB1.28176995
41TYK21.27488377
42ZAP701.23321973
43CDK61.21573682
44TEC1.20792412
45ZAK1.20466840
46LYN1.20258374
47BUB11.19773877
48RPS6KB21.17405787
49NEK21.17005369
50BMX1.15158550
51IRAK41.13755646
52LCK1.13107845
53CDC71.12222260
54ATR1.10975669
55SIK31.08213751
56FLT31.07848273
57MAP3K141.07156492
58JAK11.06786767
59PIK3CG1.05980890
60GRK61.05941336
61UHMK11.04510598
62CSF1R1.04389352
63CDK121.02119024
64MAPK111.01117314
65IRAK10.99058155
66IKBKE0.98398584
67CHEK20.98319529
68RPS6KC10.97689926
69RPS6KL10.97689926
70TBK10.96838452
71RPS6KA60.96826086
72JAK20.95843260
73PLK10.92961559
74ACVR1B0.91007784
75SYK0.89472503
76STK40.88664820
77WNK30.86383880
78PRKCQ0.85883400
79MAP3K40.83826333
80MST40.83421607
81NLK0.82043488
82CDK40.81082751
83MAPK130.79673162
84CDK190.78573839
85MAPKAPK30.78291708
86TGFBR20.76579265
87PTK2B0.74544618
88TNK20.73811471
89CHUK0.73206744
90TLK10.71363510
91TNIK0.71289619
92GRK10.70459887
93CLK10.69854143
94INSRR0.68971421
95HIPK20.68307548
96EEF2K0.67833273
97MAP2K60.66453955
98TRIM280.65176119
99ITK0.64141864
100SIK20.63099026
101STK110.62568117
102EIF2AK10.62070906
103HCK0.61874675
104PAK30.60429546
105STK160.58600659
106MARK30.58438300
107TESK20.57443419
108OXSR10.57370196
109RPS6KA40.56811216
110MAP2K30.56634569
111PASK0.56342065
112MAP3K70.56327560
113MAP3K130.55158097
114ERBB30.54657153
115VRK10.54605788
116AURKB0.54114821
117PDGFRA0.53514398
118CAMKK10.51936700
119IRAK30.51783060
120TAF10.50498476
121WNK10.49153016
122ADRBK10.47130430
123TGFBR10.47102318
124MAPK40.46632059
125SGK20.46601499
126GSK3A0.46554661
127RAF10.46097653
128CSNK2A10.46004060
129SRPK10.45765924
130CDK20.45440418
131CHEK10.45424800
132MKNK10.44660719
133BRD40.44255830
134MAPK30.44180717
135ATM0.43552844
136MAPKAPK20.42059849
137BRSK20.41845878
138KDR0.41669860
139GRK70.41301482
140RPS6KA10.40683089
141EGFR0.40395362
142TAOK20.40326988
143CCNB10.39811217
144WNK40.38638014
145FGFR30.37781621
146MAP2K20.36977467
147MAP3K50.36915163
148STK30.35931541
149PLK40.35015136
150PDK10.34490147
151ABL10.34233198
152RPS6KA50.34082713
153CAMK40.31798053
154MAP3K20.28248117

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.26518276
2DNA replication_Homo sapiens_hsa030304.11823563
3Base excision repair_Homo sapiens_hsa034103.70948263
4Primary immunodeficiency_Homo sapiens_hsa053403.01676931
5Homologous recombination_Homo sapiens_hsa034402.52273112
6Nucleotide excision repair_Homo sapiens_hsa034202.49399328
7Ribosome_Homo sapiens_hsa030102.38229311
8Spliceosome_Homo sapiens_hsa030402.34166854
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29762017
10Type I diabetes mellitus_Homo sapiens_hsa049402.21910965
11Fanconi anemia pathway_Homo sapiens_hsa034602.11558492
12Fatty acid biosynthesis_Homo sapiens_hsa000611.76358134
13RNA transport_Homo sapiens_hsa030131.71739604
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70851008
15Cell cycle_Homo sapiens_hsa041101.70440307
16Staphylococcus aureus infection_Homo sapiens_hsa051501.68940880
17p53 signaling pathway_Homo sapiens_hsa041151.68861835
18Measles_Homo sapiens_hsa051621.67223144
19Herpes simplex infection_Homo sapiens_hsa051681.66094074
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.55332507
21B cell receptor signaling pathway_Homo sapiens_hsa046621.55329122
22Non-homologous end-joining_Homo sapiens_hsa034501.48905054
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.48662067
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.46072175
25mRNA surveillance pathway_Homo sapiens_hsa030151.39189394
26Shigellosis_Homo sapiens_hsa051311.35924703
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35817677
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32775557
29Hematopoietic cell lineage_Homo sapiens_hsa046401.29713966
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26873098
31Regulation of autophagy_Homo sapiens_hsa041401.26160778
32Leishmaniasis_Homo sapiens_hsa051401.24166078
33Notch signaling pathway_Homo sapiens_hsa043301.21417727
34Antigen processing and presentation_Homo sapiens_hsa046121.18860538
35Legionellosis_Homo sapiens_hsa051341.18847878
36Phototransduction_Homo sapiens_hsa047441.18547904
37RNA polymerase_Homo sapiens_hsa030201.18340120
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16637661
39Proteasome_Homo sapiens_hsa030501.16438072
40Pyrimidine metabolism_Homo sapiens_hsa002401.13838354
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13435514
42RNA degradation_Homo sapiens_hsa030181.11960367
43Acute myeloid leukemia_Homo sapiens_hsa052211.08926332
44Epstein-Barr virus infection_Homo sapiens_hsa051691.06592394
45Graft-versus-host disease_Homo sapiens_hsa053321.04395407
46Allograft rejection_Homo sapiens_hsa053301.03255187
47Basal transcription factors_Homo sapiens_hsa030221.02641392
48Rheumatoid arthritis_Homo sapiens_hsa053231.01112584
49Viral carcinogenesis_Homo sapiens_hsa052031.00242557
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00077586
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97263181
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95548766
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.95346765
54Hepatitis B_Homo sapiens_hsa051610.92187611
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91639586
56Osteoclast differentiation_Homo sapiens_hsa043800.91071919
57T cell receptor signaling pathway_Homo sapiens_hsa046600.90785601
58One carbon pool by folate_Homo sapiens_hsa006700.90582633
59Linoleic acid metabolism_Homo sapiens_hsa005910.89576315
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89079092
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87848168
62Sulfur relay system_Homo sapiens_hsa041220.85770680
63Viral myocarditis_Homo sapiens_hsa054160.85245834
64Apoptosis_Homo sapiens_hsa042100.85241330
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82613663
66Dorso-ventral axis formation_Homo sapiens_hsa043200.82369095
67Nitrogen metabolism_Homo sapiens_hsa009100.81328311
68Chronic myeloid leukemia_Homo sapiens_hsa052200.79998727
69African trypanosomiasis_Homo sapiens_hsa051430.78944760
70mTOR signaling pathway_Homo sapiens_hsa041500.77819486
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75939154
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75394831
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74703318
74Influenza A_Homo sapiens_hsa051640.74682701
75HTLV-I infection_Homo sapiens_hsa051660.73306929
76Small cell lung cancer_Homo sapiens_hsa052220.72600275
77Systemic lupus erythematosus_Homo sapiens_hsa053220.71496083
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70141613
79Colorectal cancer_Homo sapiens_hsa052100.69917203
80Ether lipid metabolism_Homo sapiens_hsa005650.69877789
81Olfactory transduction_Homo sapiens_hsa047400.66865209
82Circadian rhythm_Homo sapiens_hsa047100.65407153
83Chemokine signaling pathway_Homo sapiens_hsa040620.65209198
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64494622
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61777662
86FoxO signaling pathway_Homo sapiens_hsa040680.61721364
87Taste transduction_Homo sapiens_hsa047420.60398177
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59110513
89Non-small cell lung cancer_Homo sapiens_hsa052230.59058462
90Folate biosynthesis_Homo sapiens_hsa007900.55356607
91Salmonella infection_Homo sapiens_hsa051320.54735376
92MicroRNAs in cancer_Homo sapiens_hsa052060.54667016
93Adherens junction_Homo sapiens_hsa045200.54245026
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53752804
95Pancreatic cancer_Homo sapiens_hsa052120.53494814
96Asthma_Homo sapiens_hsa053100.53207468
97Tuberculosis_Homo sapiens_hsa051520.52891995
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.52090301
99Malaria_Homo sapiens_hsa051440.50254632
100Phagosome_Homo sapiens_hsa041450.49899836
101Selenocompound metabolism_Homo sapiens_hsa004500.49831507
102TNF signaling pathway_Homo sapiens_hsa046680.49652354
103Prolactin signaling pathway_Homo sapiens_hsa049170.49522318
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.49109854
105Toxoplasmosis_Homo sapiens_hsa051450.48821766
106VEGF signaling pathway_Homo sapiens_hsa043700.47235175
107Thyroid cancer_Homo sapiens_hsa052160.47111674
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46960942
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46390352
110Arachidonic acid metabolism_Homo sapiens_hsa005900.45015100
111Platelet activation_Homo sapiens_hsa046110.44828392
112Autoimmune thyroid disease_Homo sapiens_hsa053200.44667514
113TGF-beta signaling pathway_Homo sapiens_hsa043500.44092350
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44078801
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42734821
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42203454
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41995273
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41716421
119Caffeine metabolism_Homo sapiens_hsa002320.40972519
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39039565
121Morphine addiction_Homo sapiens_hsa050320.37325477
122Inositol phosphate metabolism_Homo sapiens_hsa005620.37156078
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36503068
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.36193350
125Hepatitis C_Homo sapiens_hsa051600.35882346
126ABC transporters_Homo sapiens_hsa020100.35455593
127Hippo signaling pathway_Homo sapiens_hsa043900.35032591
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33514314
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.32225958
130Purine metabolism_Homo sapiens_hsa002300.31354196
131Pertussis_Homo sapiens_hsa051330.30764714
132Other glycan degradation_Homo sapiens_hsa005110.30752662
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30657122
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30366812
135Pathways in cancer_Homo sapiens_hsa052000.30041480
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29863804
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28648351

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