CRMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* pyrimidine nucleobase catabolic process (GO:0006208)7.54348789
2layer formation in cerebral cortex (GO:0021819)6.10682474
3* nucleobase catabolic process (GO:0046113)5.92616186
4neuron cell-cell adhesion (GO:0007158)5.57668737
5cell migration in hindbrain (GO:0021535)5.47809140
6response to pheromone (GO:0019236)5.46960332
7central nervous system projection neuron axonogenesis (GO:0021952)5.42932661
8vocalization behavior (GO:0071625)5.37742324
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.29030025
10protein localization to synapse (GO:0035418)5.12198914
11regulation of short-term neuronal synaptic plasticity (GO:0048172)5.10346876
12dendritic spine morphogenesis (GO:0060997)5.09727746
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.07755218
14neuron recognition (GO:0008038)5.07689373
15negative regulation of microtubule polymerization (GO:0031115)5.02450865
16synaptic vesicle maturation (GO:0016188)4.95820493
17dendrite morphogenesis (GO:0048813)4.92494497
18axonal fasciculation (GO:0007413)4.90126116
19regulation of synapse structural plasticity (GO:0051823)4.86844332
20locomotory exploration behavior (GO:0035641)4.79434208
21exploration behavior (GO:0035640)4.70170098
22regulation of glutamate receptor signaling pathway (GO:1900449)4.58080653
23establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.50391908
24mitochondrion transport along microtubule (GO:0047497)4.50391908
25synaptic vesicle exocytosis (GO:0016079)4.47771372
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.44947578
27auditory behavior (GO:0031223)4.39990873
28establishment of mitochondrion localization (GO:0051654)4.36473971
29postsynaptic membrane organization (GO:0001941)4.33561465
30positive regulation of synapse maturation (GO:0090129)4.29188195
31glutamate secretion (GO:0014047)4.24876014
32regulation of synaptic vesicle exocytosis (GO:2000300)4.23987674
33central nervous system neuron axonogenesis (GO:0021955)4.14098048
34axon extension (GO:0048675)4.13306490
35clathrin coat assembly (GO:0048268)3.98706622
36behavioral response to nicotine (GO:0035095)3.88201220
37neurofilament cytoskeleton organization (GO:0060052)3.80345006
38response to auditory stimulus (GO:0010996)3.76713076
39neuron projection extension (GO:1990138)3.75694894
40ionotropic glutamate receptor signaling pathway (GO:0035235)3.73234200
41positive regulation of filopodium assembly (GO:0051491)3.70085002
42cerebellum development (GO:0021549)3.69592903
43hippocampus development (GO:0021766)3.65889057
44regulation of synaptic vesicle transport (GO:1902803)3.65204449
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.63660462
46neurotransmitter-gated ion channel clustering (GO:0072578)3.60234999
47regulation of neuronal synaptic plasticity (GO:0048168)3.58823123
48proline transport (GO:0015824)3.58776909
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.57553541
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57155182
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.53825561
52positive regulation of dendritic spine morphogenesis (GO:0061003)3.53028805
53cerebellar Purkinje cell layer development (GO:0021680)3.51926532
54neurotransmitter secretion (GO:0007269)3.49652133
55positive regulation of axon extension (GO:0045773)3.47047285
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44819425
57regulation of axon extension (GO:0030516)3.43261172
58glutamate receptor signaling pathway (GO:0007215)3.41056410
59cerebral cortex neuron differentiation (GO:0021895)3.41015261
60calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.40214026
61positive regulation of dendritic spine development (GO:0060999)3.39741574
62neuron migration (GO:0001764)3.39550028
63synapse assembly (GO:0007416)3.38629303
64regulation of dendritic spine morphogenesis (GO:0061001)3.37998342
65synaptic transmission, glutamatergic (GO:0035249)3.37978488
66positive regulation of synapse assembly (GO:0051965)3.36891700
67cerebral cortex radially oriented cell migration (GO:0021799)3.34173236
68regulation of microtubule polymerization (GO:0031113)3.33959709
69regulation of cAMP-dependent protein kinase activity (GO:2000479)3.33816910
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32514627
71regulation of synapse maturation (GO:0090128)3.30711445
72retinal ganglion cell axon guidance (GO:0031290)3.28184401
73mechanosensory behavior (GO:0007638)3.27540631
74neuronal ion channel clustering (GO:0045161)3.26606803
75establishment of nucleus localization (GO:0040023)3.25976787
76synaptic vesicle endocytosis (GO:0048488)3.25694784
77dendrite development (GO:0016358)3.23289112
78organelle transport along microtubule (GO:0072384)3.22409427
79neuromuscular synaptic transmission (GO:0007274)3.22396316
80dopamine receptor signaling pathway (GO:0007212)3.21365324
81presynaptic membrane assembly (GO:0097105)3.19877653
82axon cargo transport (GO:0008088)3.18392879
83regulation of synapse organization (GO:0050807)3.15600659
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.14063378
85regulation of extent of cell growth (GO:0061387)3.13146232
86dendritic spine organization (GO:0097061)3.11396889
87regulation of respiratory system process (GO:0044065)3.11188332
88regulation of synapse assembly (GO:0051963)3.07177032
89neuron-neuron synaptic transmission (GO:0007270)3.06939982
90positive regulation of mitochondrial fission (GO:0090141)3.06737021
91negative regulation of axonogenesis (GO:0050771)3.06244457
92glycosphingolipid biosynthetic process (GO:0006688)3.05554798
93gamma-aminobutyric acid transport (GO:0015812)3.04593311
94cerebellar granule cell differentiation (GO:0021707)3.03979317
95presynaptic membrane organization (GO:0097090)3.02721977
96negative regulation of axon extension (GO:0030517)3.02136507
97synapse organization (GO:0050808)3.01549055
98neuron projection morphogenesis (GO:0048812)3.01234591
99neuronal action potential propagation (GO:0019227)2.99890461
100adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.99526623
101homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.98643793
102transmission of nerve impulse (GO:0019226)2.98634213
103axonogenesis (GO:0007409)2.97267726
104spinal cord development (GO:0021510)2.96620759
105regulation of dendritic spine development (GO:0060998)2.96224180
106positive regulation of membrane potential (GO:0045838)2.95757025
107intraspecies interaction between organisms (GO:0051703)2.95694317
108social behavior (GO:0035176)2.95694317
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95215278
110regulation of filopodium assembly (GO:0051489)2.92719325
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.89437784
112innervation (GO:0060384)2.88993006
113regulation of postsynaptic membrane potential (GO:0060078)2.88891938
114regulation of vesicle fusion (GO:0031338)2.88827384
115membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87723774
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86447576
117regulation of synaptic transmission, glutamatergic (GO:0051966)2.85152214
118negative regulation of oligodendrocyte differentiation (GO:0048715)2.83998331
119substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.83386472
120substrate-independent telencephalic tangential migration (GO:0021826)2.83386472
121sequestering of actin monomers (GO:0042989)2.82860476
122adult walking behavior (GO:0007628)2.81997387
123protein localization to cilium (GO:0061512)2.80944742
124olfactory bulb development (GO:0021772)2.79966608
125regulation of neurotransmitter levels (GO:0001505)2.77197061
126startle response (GO:0001964)2.77098597
127neurotransmitter transport (GO:0006836)2.73408326
128regulation of feeding behavior (GO:0060259)2.66583837
129ganglion development (GO:0061548)2.64006540
130limb bud formation (GO:0060174)2.63693706
131forebrain neuron differentiation (GO:0021879)2.63227100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.77229160
2GBX2_23144817_ChIP-Seq_PC3_Human3.37779936
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.36449608
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08128803
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.95120062
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94043902
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.89993267
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.83946141
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71219097
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64310243
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64310243
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56928042
13* EZH2_27294783_Chip-Seq_ESCs_Mouse2.53460753
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47809046
15* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.46772010
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45362131
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39558718
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37286076
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.34453521
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.32282739
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30854274
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24568385
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22689177
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.17699298
25DROSHA_22980978_ChIP-Seq_HELA_Human2.16063696
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14458328
27* RARB_27405468_Chip-Seq_BRAIN_Mouse2.13449296
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04230840
29ZNF274_21170338_ChIP-Seq_K562_Hela1.93876472
30AR_21572438_ChIP-Seq_LNCaP_Human1.90642403
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81645855
32IGF1R_20145208_ChIP-Seq_DFB_Human1.80157499
33* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70002526
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68504382
35* CBX2_27304074_Chip-Seq_ESCs_Mouse1.66062586
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.63816910
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63035933
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62700387
39RNF2_27304074_Chip-Seq_NSC_Mouse1.61533626
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.56200300
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55971366
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53777256
43FUS_26573619_Chip-Seq_HEK293_Human1.53661983
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52374479
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51761784
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.51071081
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48524937
48TAF15_26573619_Chip-Seq_HEK293_Human1.43221457
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42489476
50* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41856779
51OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40397673
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37707093
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37371723
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36566418
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36396311
56* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34315325
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.28570437
58KDM2B_26808549_Chip-Seq_K562_Human1.28352241
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26541968
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23387418
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21968366
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20757453
63SMAD4_21799915_ChIP-Seq_A2780_Human1.20339509
64VDR_22108803_ChIP-Seq_LS180_Human1.20154326
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19670036
66* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18975874
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.17244798
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16157115
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15809686
70AR_19668381_ChIP-Seq_PC3_Human1.14068197
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13839671
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13521278
73EWS_26573619_Chip-Seq_HEK293_Human1.12860947
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.12809864
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.12483812
76P300_19829295_ChIP-Seq_ESCs_Human1.12127730
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11132988
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10536684
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10431474
80AR_25329375_ChIP-Seq_VCAP_Human1.09159702
81* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08560797
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08440296
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08440296
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.08346746
85* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07324694
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07048709
87* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06078263
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05532847
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.05138389
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05040904
91CBP_20019798_ChIP-Seq_JUKART_Human1.05040904
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04467448
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04392873
94ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01446563
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00769132
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.00052287
97* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99305507
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.98832050
99IRF1_19129219_ChIP-ChIP_H3396_Human0.98529899
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97731446
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97521113
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97484743
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97454486
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.96463172
105SOX9_26525672_Chip-Seq_HEART_Mouse0.96224729
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96212463
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94919615
108AHR_22903824_ChIP-Seq_MCF-7_Human0.94543795
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94343084
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94047940
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.92323296
112KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91604412
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91112887
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90866631
115STAT3_23295773_ChIP-Seq_U87_Human0.90693872
116TCF4_23295773_ChIP-Seq_U87_Human0.90412200
117* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89385945
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88868144
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88626912
120TAL1_26923725_Chip-Seq_HPCs_Mouse0.88288782
121CTCF_27219007_Chip-Seq_Bcells_Human0.88160812
122* TET1_21490601_ChIP-Seq_MESCs_Mouse0.86779016
123JUN_21703547_ChIP-Seq_K562_Human0.86440199
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85921136
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85061207
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84545504
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84222983
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84070739
129RUNX2_22187159_ChIP-Seq_PCA_Human0.83220277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.65737027
2MP0003880_abnormal_central_pattern3.96914192
3MP0005423_abnormal_somatic_nervous3.85215896
4MP0004270_analgesia3.83481137
5* MP0003635_abnormal_synaptic_transmissio3.56256977
6MP0000778_abnormal_nervous_system3.54757007
7* MP0002063_abnormal_learning/memory/cond3.21742073
8MP0006276_abnormal_autonomic_nervous2.81366022
9MP0002734_abnormal_mechanical_nocicepti2.67017148
10MP0009745_abnormal_behavioral_response2.55593455
11MP0002184_abnormal_innervation2.54440712
12MP0000569_abnormal_digit_pigmentation2.49408626
13MP0002572_abnormal_emotion/affect_behav2.46730256
14MP0001968_abnormal_touch/_nociception2.37848587
15MP0002733_abnormal_thermal_nociception2.28272665
16MP0001440_abnormal_grooming_behavior2.27282049
17MP0002735_abnormal_chemical_nociception2.24067350
18MP0002064_seizures2.22341951
19MP0001486_abnormal_startle_reflex2.20336512
20MP0002557_abnormal_social/conspecific_i2.08012580
21* MP0004811_abnormal_neuron_physiology2.07319482
22MP0003329_amyloid_beta_deposits1.97869135
23MP0004858_abnormal_nervous_system1.93581348
24MP0001529_abnormal_vocalization1.93475106
25MP0000955_abnormal_spinal_cord1.92459886
26MP0001970_abnormal_pain_threshold1.87864002
27MP0003122_maternal_imprinting1.85931000
28MP0009046_muscle_twitch1.85355870
29MP0009780_abnormal_chondrocyte_physiolo1.83621751
30MP0004924_abnormal_behavior1.80446585
31MP0005386_behavior/neurological_phenoty1.80446585
32MP0005645_abnormal_hypothalamus_physiol1.74918005
33MP0002067_abnormal_sensory_capabilities1.67970741
34MP0001984_abnormal_olfaction1.67700876
35* MP0002882_abnormal_neuron_morphology1.65016557
36MP0002736_abnormal_nociception_after1.63653437
37MP0002272_abnormal_nervous_system1.58748802
38MP0002909_abnormal_adrenal_gland1.56619355
39* MP0002152_abnormal_brain_morphology1.52891806
40MP0004885_abnormal_endolymph1.49334876
41MP0002102_abnormal_ear_morphology1.40279205
42MP0000631_abnormal_neuroendocrine_gland1.38526822
43MP0002066_abnormal_motor_capabilities/c1.36556157
44MP0005187_abnormal_penis_morphology1.36165467
45* MP0003861_abnormal_nervous_system1.35156744
46MP0008877_abnormal_DNA_methylation1.30291100
47MP0008569_lethality_at_weaning1.29653331
48MP0000049_abnormal_middle_ear1.29441628
49MP0005394_taste/olfaction_phenotype1.28296973
50MP0005499_abnormal_olfactory_system1.28296973
51MP0002638_abnormal_pupillary_reflex1.27049558
52MP0000537_abnormal_urethra_morphology1.26095104
53MP0001348_abnormal_lacrimal_gland1.17420379
54MP0001905_abnormal_dopamine_level1.15821744
55MP0001502_abnormal_circadian_rhythm1.14244231
56MP0008789_abnormal_olfactory_epithelium1.13252581
57MP0003879_abnormal_hair_cell1.13158638
58MP0001501_abnormal_sleep_pattern1.10923838
59MP0008961_abnormal_basal_metabolism1.10407065
60MP0010386_abnormal_urinary_bladder1.10043478
61MP0003787_abnormal_imprinting1.09195174
62MP0004742_abnormal_vestibular_system1.07880210
63MP0003119_abnormal_digestive_system1.05596063
64MP0005253_abnormal_eye_physiology1.05472035
65MP0003137_abnormal_impulse_conducting1.04927511
66MP0002752_abnormal_somatic_nervous1.04888765
67MP0006072_abnormal_retinal_apoptosis1.04755314
68MP0005551_abnormal_eye_electrophysiolog1.01079395
69MP0002069_abnormal_eating/drinking_beha1.00019456
70MP0004133_heterotaxia1.00013807
71MP0000566_synostosis0.99438669
72MP0002751_abnormal_autonomic_nervous0.98452629
73MP0003121_genomic_imprinting0.98154673
74MP0003890_abnormal_embryonic-extraembry0.97659394
75MP0000751_myopathy0.92429808
76MP0005646_abnormal_pituitary_gland0.92060643
77MP0004142_abnormal_muscle_tone0.91513802
78MP0001986_abnormal_taste_sensitivity0.86608619
79MP0001188_hyperpigmentation0.85443883
80MP0002233_abnormal_nose_morphology0.84467236
81MP0003634_abnormal_glial_cell0.84433405
82MP0001177_atelectasis0.82610930
83MP0000604_amyloidosis0.82080966
84MP0002081_perinatal_lethality0.80899620
85MP0004233_abnormal_muscle_weight0.79361657
86MP0001299_abnormal_eye_distance/0.77820734
87MP0002653_abnormal_ependyma_morphology0.77326732
88MP0005195_abnormal_posterior_eye0.76271200
89MP0006292_abnormal_olfactory_placode0.75113613
90MP0001963_abnormal_hearing_physiology0.74415907
91MP0002822_catalepsy0.74327483
92MP0003938_abnormal_ear_development0.73823116
93MP0000026_abnormal_inner_ear0.73138535
94MP0008995_early_reproductive_senescence0.72784074
95MP0003631_nervous_system_phenotype0.72652491
96MP0002229_neurodegeneration0.70946502
97MP0004085_abnormal_heartbeat0.70906678
98MP0003633_abnormal_nervous_system0.70105996
99MP0003755_abnormal_palate_morphology0.69957986
100MP0010770_preweaning_lethality0.69088574
101MP0002082_postnatal_lethality0.69088574
102MP0002234_abnormal_pharynx_morphology0.68274050
103MP0003937_abnormal_limbs/digits/tail_de0.67739464
104MP0010769_abnormal_survival0.67195260
105MP0003567_abnormal_fetal_cardiomyocyte0.66127121
106MP0005391_vision/eye_phenotype0.65296844
107MP0003385_abnormal_body_wall0.64731905
108MP0004145_abnormal_muscle_electrophysio0.64251138
109MP0003632_abnormal_nervous_system0.64198026
110MP0000538_abnormal_urinary_bladder0.64164870
111MP0003136_yellow_coat_color0.64143652
112MP0010768_mortality/aging0.63450007
113MP0000534_abnormal_ureter_morphology0.63002837
114MP0010030_abnormal_orbit_morphology0.62916162
115MP0005248_abnormal_Harderian_gland0.62871289
116MP0001943_abnormal_respiration0.62666656
117MP0001485_abnormal_pinna_reflex0.62360090

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.83911270
2Mutism (HP:0002300)4.62303737
3Amyotrophic lateral sclerosis (HP:0007354)4.54185522
4Polyphagia (HP:0002591)4.34402503
5Supranuclear gaze palsy (HP:0000605)4.06439819
6Limb dystonia (HP:0002451)4.04198481
7Focal seizures (HP:0007359)3.93174794
8Focal motor seizures (HP:0011153)3.90569364
9Visual hallucinations (HP:0002367)3.90123728
10Ankle clonus (HP:0011448)3.60471899
11Excessive salivation (HP:0003781)3.59174130
12Drooling (HP:0002307)3.59174130
13Epileptic encephalopathy (HP:0200134)3.52811199
14Abnormality of the corticospinal tract (HP:0002492)3.45623321
15Papilledema (HP:0001085)3.41498033
16Akinesia (HP:0002304)3.27015700
17Broad-based gait (HP:0002136)3.26041501
18Retinal dysplasia (HP:0007973)3.21843577
19Lissencephaly (HP:0001339)3.21780843
20Poor eye contact (HP:0000817)3.16062879
21Neurofibrillary tangles (HP:0002185)3.13550776
22Aplasia/Hypoplasia of the brainstem (HP:0007362)3.12369068
23Hypoplasia of the brainstem (HP:0002365)3.12369068
24Cerebral inclusion bodies (HP:0100314)3.12302124
25Abnormal eating behavior (HP:0100738)3.02981264
26Cortical dysplasia (HP:0002539)2.96794790
27Pachygyria (HP:0001302)2.96793493
28Progressive cerebellar ataxia (HP:0002073)2.96600749
29Inappropriate behavior (HP:0000719)2.91289301
30Apathy (HP:0000741)2.89755109
31Urinary urgency (HP:0000012)2.87758738
32Failure to thrive in infancy (HP:0001531)2.87361202
33Amblyopia (HP:0000646)2.80063853
34Abnormal social behavior (HP:0012433)2.74708077
35Impaired social interactions (HP:0000735)2.74708077
36Hemiparesis (HP:0001269)2.71269607
37Agitation (HP:0000713)2.68949701
38Sleep apnea (HP:0010535)2.68573071
39Termporal pattern (HP:0011008)2.68203952
40Insidious onset (HP:0003587)2.68203952
41Diminished motivation (HP:0000745)2.65487345
42Progressive inability to walk (HP:0002505)2.64889380
43Atrophy/Degeneration involving motor neurons (HP:0007373)2.64444765
44Morphological abnormality of the pyramidal tract (HP:0002062)2.63318882
45Megalencephaly (HP:0001355)2.62453582
46Abnormality of the lower motor neuron (HP:0002366)2.60567032
47Medial flaring of the eyebrow (HP:0010747)2.60042229
48EEG with generalized epileptiform discharges (HP:0011198)2.59831885
49Congenital primary aphakia (HP:0007707)2.59567674
50Insomnia (HP:0100785)2.57638642
51Hypsarrhythmia (HP:0002521)2.57185598
52Spastic gait (HP:0002064)2.55201788
53Epileptiform EEG discharges (HP:0011182)2.54359439
54Nephrogenic diabetes insipidus (HP:0009806)2.53780940
55Hepatoblastoma (HP:0002884)2.49363659
56Urinary bladder sphincter dysfunction (HP:0002839)2.48519002
57Torticollis (HP:0000473)2.46904766
58Spastic tetraplegia (HP:0002510)2.44294255
59Diplopia (HP:0000651)2.42441358
60Abnormality of binocular vision (HP:0011514)2.42441358
61Hyperventilation (HP:0002883)2.41825041
62Vaginal atresia (HP:0000148)2.41700655
63Obstructive sleep apnea (HP:0002870)2.40364385
64Genetic anticipation (HP:0003743)2.39444940
65Genital tract atresia (HP:0001827)2.38862614
66Inability to walk (HP:0002540)2.38751836
67Impaired vibration sensation in the lower limbs (HP:0002166)2.36597601
68Split foot (HP:0001839)2.35749712
69Absence seizures (HP:0002121)2.35236858
70Truncal ataxia (HP:0002078)2.34693428
71Hyperacusis (HP:0010780)2.32960212
72Depression (HP:0000716)2.31465329
73Exotropia (HP:0000577)2.30316493
74Febrile seizures (HP:0002373)2.29566626
75Gait imbalance (HP:0002141)2.29345785
76Shoulder girdle muscle weakness (HP:0003547)2.25652139
77Generalized tonic-clonic seizures (HP:0002069)2.25526162
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.24302432
79Specific learning disability (HP:0001328)2.24066050
80Action tremor (HP:0002345)2.23763614
81Stereotypic behavior (HP:0000733)2.23552803
82Lower limb muscle weakness (HP:0007340)2.22497436
83Focal dystonia (HP:0004373)2.20958020
84Disinhibition (HP:0000734)2.20806476
85Hypoplasia of the corpus callosum (HP:0002079)2.20265021
86Abnormality of salivation (HP:0100755)2.19460545
87Degeneration of the lateral corticospinal tracts (HP:0002314)2.19125555
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19125555
89Elfin facies (HP:0004428)2.16789200
90Sacral dimple (HP:0000960)2.16326870
91Fetal akinesia sequence (HP:0001989)2.14314829
92Intestinal atresia (HP:0011100)2.13483354
93Abnormality of the labia minora (HP:0012880)2.11643638
94Sporadic (HP:0003745)2.10950751
95Dialeptic seizures (HP:0011146)2.09738941
96Type II lissencephaly (HP:0007260)2.08907651
97Craniofacial dystonia (HP:0012179)2.06834007
98Aqueductal stenosis (HP:0002410)2.05144440
99Protruding tongue (HP:0010808)2.04420525
100Pointed chin (HP:0000307)2.01889799
101Oligodactyly (hands) (HP:0001180)2.00054855
102Esotropia (HP:0000565)1.97840587
103Astrocytoma (HP:0009592)1.97095839
104Abnormality of the astrocytes (HP:0100707)1.97095839
105Polymicrogyria (HP:0002126)1.97034248
106Poor suck (HP:0002033)1.95657998
107Optic nerve hypoplasia (HP:0000609)1.94198662
108Nephronophthisis (HP:0000090)1.94051305
109Overriding aorta (HP:0002623)1.93073086
110Absent speech (HP:0001344)1.92610113
111Atonic seizures (HP:0010819)1.92508477
112Open mouth (HP:0000194)1.91639461
113Ulnar claw (HP:0001178)1.88768732
114Muscular hypotonia of the trunk (HP:0008936)1.88721685
115Abnormality of the hip-girdle musculature (HP:0001445)1.88713028
116Abnormality of the musculature of the pelvis (HP:0001469)1.88713028
117Anxiety (HP:0000739)1.87880526
118Megalocornea (HP:0000485)1.86544128
119Abnormal hair whorl (HP:0010721)1.85506933
120Hypoventilation (HP:0002791)1.85350370
121Poor coordination (HP:0002370)1.83687287
122Peripheral hypomyelination (HP:0007182)1.80908859
123True hermaphroditism (HP:0010459)1.78984665
124Renal hypoplasia (HP:0000089)1.78188234
125Narrow forehead (HP:0000341)1.77385052
126Abnormality of midbrain morphology (HP:0002418)1.77296323
127Molar tooth sign on MRI (HP:0002419)1.77296323
128Micropenis (HP:0000054)1.77200765
129Pendular nystagmus (HP:0012043)1.74918388
130Pancreatic cysts (HP:0001737)1.74114757
131Septo-optic dysplasia (HP:0100842)1.67670831
132Intellectual disability, severe (HP:0010864)1.67650604
133Postaxial hand polydactyly (HP:0001162)1.66456816
134Intellectual disability, moderate (HP:0002342)1.66098831
135Pancreatic fibrosis (HP:0100732)1.66086009
136Broad foot (HP:0001769)1.66015917
137Labial hypoplasia (HP:0000066)1.65556056
138Cutaneous finger syndactyly (HP:0010554)1.63626548
139Paraplegia (HP:0010550)1.62513547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK18.15577473
2MAP3K93.66663294
3NTRK22.89410048
4MINK12.86378177
5MAP3K42.44098441
6KSR12.38202430
7MAPK132.38096201
8NTRK32.31182041
9PHKG22.24308636
10PHKG12.24308636
11ERBB32.23594979
12* DYRK22.17814340
13TRIM282.14080435
14SIK32.13075041
15EPHA32.04262870
16MAP2K72.04068395
17SIK22.01222545
18PAK61.87135249
19LATS21.77525207
20MAP4K21.75475300
21DAPK21.66315245
22BCR1.57904293
23UHMK11.57362635
24EPHA41.54149275
25PINK11.49135776
26WNK31.48482241
27EPHB21.48038025
28LIMK11.47626205
29MAP3K121.39299201
30MAP2K41.36126094
31TYRO31.33435321
32CASK1.32544785
33CSNK1G21.28768690
34* CDK51.25454398
35FGFR21.23721175
36DYRK31.10997092
37PNCK1.09838873
38CDK181.09222853
39DYRK1A1.07271554
40ICK1.06363044
41CAMKK11.06174168
42MARK21.05814686
43DYRK1B1.01944976
44CDK140.99515897
45SRPK10.98561247
46CDK150.98150243
47TNIK0.97213767
48DAPK10.96696983
49CSNK1G30.95607928
50PAK30.92790473
51KSR20.91409775
52CDK190.90369798
53PLK20.89292765
54CDK11A0.86910665
55PKN10.84883792
56PRKCZ0.84868761
57PRKCG0.84553725
58RET0.82781808
59PRKD30.80592951
60NTRK10.79964585
61CSNK1A1L0.78820448
62RPS6KA20.71964755
63MAP3K60.67974423
64GRK50.67769839
65BMPR1B0.63866354
66STK110.63292315
67TESK10.62658919
68RPS6KA40.59506863
69PRPF4B0.58592543
70SGK20.56692009
71CAMK1G0.56544860
72CCNB10.56105868
73MAPK120.54769658
74INSRR0.52777285
75CSNK1G10.52292608
76CAMK2A0.52122556
77ADRBK20.51320745
78TAOK10.51122544
79CAMK40.49088559
80SCYL20.48574759
81ERBB20.48160449
82MAP2K60.46690720
83TSSK60.45291660
84CSNK1A10.40182455
85PRKACA0.39517149
86MAP3K20.39289678
87* MAPK90.39200549
88CAMKK20.38622040
89SGK4940.38383404
90SGK2230.38383404
91MKNK20.38122660
92PRKCE0.37897265
93* FYN0.37630834
94BCKDK0.37409994
95OXSR10.36659734
96ALK0.36577529
97CAMK2B0.35828333
98PDGFRA0.35140385
99PRKACB0.34940160
100PRKCI0.34576952
101CSNK1D0.31538908
102SGK10.31444515
103PRKAA10.31316964
104FER0.30827517
105PRKG10.30130556
106ROCK10.29361256
107CAMK2G0.29179455
108MAPK40.28352632
109IRAK20.28200046
110MAPK80.27772604
111MKNK10.27647981
112ILK0.27414896
113TESK20.27134820
114RPS6KA30.27020376
115STK38L0.26183901
116CSNK1E0.26157684
117GRK10.25837763
118CAMK10.25328916
119PRKDC0.25090516
120ADRBK10.24541954
121PRKCH0.24381664
122FGFR10.23833013
123MAP3K50.23793088
124LMTK20.22425417
125MAPK100.21861697
126GSK3B0.21682933
127EIF2AK20.21501849
128FES0.20215201

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36344723
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.95953962
3Synaptic vesicle cycle_Homo sapiens_hsa047212.87652779
4Axon guidance_Homo sapiens_hsa043602.60990198
5GABAergic synapse_Homo sapiens_hsa047272.35260390
6Circadian entrainment_Homo sapiens_hsa047132.33361701
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30100130
8Glutamatergic synapse_Homo sapiens_hsa047242.27920381
9Dopaminergic synapse_Homo sapiens_hsa047282.25793504
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22902702
11Morphine addiction_Homo sapiens_hsa050322.08402274
12Long-term potentiation_Homo sapiens_hsa047202.05087045
13Cholinergic synapse_Homo sapiens_hsa047252.02362757
14Olfactory transduction_Homo sapiens_hsa047401.99689861
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99558473
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78486515
17Gap junction_Homo sapiens_hsa045401.74378279
18Amphetamine addiction_Homo sapiens_hsa050311.73171407
19Steroid biosynthesis_Homo sapiens_hsa001001.72674885
20Cocaine addiction_Homo sapiens_hsa050301.64821649
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59744599
22Serotonergic synapse_Homo sapiens_hsa047261.58427335
23Endometrial cancer_Homo sapiens_hsa052131.48864795
24Insulin secretion_Homo sapiens_hsa049111.47455135
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47036916
26Oxidative phosphorylation_Homo sapiens_hsa001901.46694349
27Oxytocin signaling pathway_Homo sapiens_hsa049211.46679482
28Colorectal cancer_Homo sapiens_hsa052101.46210858
29Long-term depression_Homo sapiens_hsa047301.45637160
30ErbB signaling pathway_Homo sapiens_hsa040121.44917414
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.43746670
32Parkinsons disease_Homo sapiens_hsa050121.42859647
33Salivary secretion_Homo sapiens_hsa049701.38611502
34Renin secretion_Homo sapiens_hsa049241.35439240
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32544143
36Taste transduction_Homo sapiens_hsa047421.31513930
37Glioma_Homo sapiens_hsa052141.31180987
38GnRH signaling pathway_Homo sapiens_hsa049121.29024779
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28737167
40Estrogen signaling pathway_Homo sapiens_hsa049151.25530305
41Gastric acid secretion_Homo sapiens_hsa049711.25203966
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22553205
43Type II diabetes mellitus_Homo sapiens_hsa049301.20794369
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.15729884
45Renal cell carcinoma_Homo sapiens_hsa052111.13636377
46Oocyte meiosis_Homo sapiens_hsa041141.10651365
47Protein export_Homo sapiens_hsa030601.08598431
48Melanogenesis_Homo sapiens_hsa049161.08529811
49VEGF signaling pathway_Homo sapiens_hsa043701.02904836
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01479447
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00055950
52Alzheimers disease_Homo sapiens_hsa050100.99423749
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95755287
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94291629
55Calcium signaling pathway_Homo sapiens_hsa040200.93524036
56Alcoholism_Homo sapiens_hsa050340.90294916
57cAMP signaling pathway_Homo sapiens_hsa040240.89508570
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87990966
59Choline metabolism in cancer_Homo sapiens_hsa052310.87957336
60Huntingtons disease_Homo sapiens_hsa050160.85190321
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84383054
62Wnt signaling pathway_Homo sapiens_hsa043100.82352035
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81987210
64mTOR signaling pathway_Homo sapiens_hsa041500.81837295
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80909904
66Collecting duct acid secretion_Homo sapiens_hsa049660.80588196
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.79766202
68Viral myocarditis_Homo sapiens_hsa054160.79183196
69Vibrio cholerae infection_Homo sapiens_hsa051100.78932594
70Hippo signaling pathway_Homo sapiens_hsa043900.77646505
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77022231
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76853843
73MAPK signaling pathway_Homo sapiens_hsa040100.75918062
74Phototransduction_Homo sapiens_hsa047440.75129147
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75034123
76Ras signaling pathway_Homo sapiens_hsa040140.75014512
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74404554
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74066585
79Cardiac muscle contraction_Homo sapiens_hsa042600.73690479
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.73353078
81Insulin signaling pathway_Homo sapiens_hsa049100.71393491
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70966970
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70940389
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70723614
85Regulation of autophagy_Homo sapiens_hsa041400.70585932
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69326479
87Non-small cell lung cancer_Homo sapiens_hsa052230.68605807
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66567761
89Basal cell carcinoma_Homo sapiens_hsa052170.65800373
90Ether lipid metabolism_Homo sapiens_hsa005650.64733155
91Endocytosis_Homo sapiens_hsa041440.63081892
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62012948
93Butanoate metabolism_Homo sapiens_hsa006500.61392707
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60533411
95Rap1 signaling pathway_Homo sapiens_hsa040150.59967615
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59259151
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58357691
98Hedgehog signaling pathway_Homo sapiens_hsa043400.57545110
99Dilated cardiomyopathy_Homo sapiens_hsa054140.56641355
100Prion diseases_Homo sapiens_hsa050200.56624927
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56322339
102Basal transcription factors_Homo sapiens_hsa030220.55552552
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54437182
104Circadian rhythm_Homo sapiens_hsa047100.53723101
105Dorso-ventral axis formation_Homo sapiens_hsa043200.53653633
106AMPK signaling pathway_Homo sapiens_hsa041520.51460159
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50356811
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50148072
109N-Glycan biosynthesis_Homo sapiens_hsa005100.49810891
110Tight junction_Homo sapiens_hsa045300.48625495
111Prolactin signaling pathway_Homo sapiens_hsa049170.48233875
112mRNA surveillance pathway_Homo sapiens_hsa030150.47179042
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45895197
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45175065
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45046696
116Pancreatic cancer_Homo sapiens_hsa052120.44812222
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.44261891
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43401403
119Glucagon signaling pathway_Homo sapiens_hsa049220.42950595
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42692228
121Phagosome_Homo sapiens_hsa041450.41482046
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38719364
123beta-Alanine metabolism_Homo sapiens_hsa004100.37684999
124Selenocompound metabolism_Homo sapiens_hsa004500.29591645
125Ovarian steroidogenesis_Homo sapiens_hsa049130.27990175
126Linoleic acid metabolism_Homo sapiens_hsa005910.23575034
127RNA degradation_Homo sapiens_hsa030180.22405475
128Fatty acid elongation_Homo sapiens_hsa000620.22305772
129Salmonella infection_Homo sapiens_hsa051320.21831318

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