CRNKL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)6.06489850
2mitotic metaphase plate congression (GO:0007080)5.75744712
3regulation of spindle organization (GO:0090224)4.89819878
4protein localization to kinetochore (GO:0034501)4.82186285
5metaphase plate congression (GO:0051310)4.80675285
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.71644692
7cytoplasmic mRNA processing body assembly (GO:0033962)4.70785550
8DNA replication checkpoint (GO:0000076)4.60101220
9ribosome assembly (GO:0042255)4.52912682
10histone H2B ubiquitination (GO:0033523)4.48771064
11attachment of spindle microtubules to kinetochore (GO:0008608)4.34371219
12regulation of mitotic spindle organization (GO:0060236)4.32012844
13protein localization to chromosome, centromeric region (GO:0071459)4.31819535
14purine nucleobase biosynthetic process (GO:0009113)4.29032770
15DNA ligation (GO:0006266)4.23118426
16establishment of chromosome localization (GO:0051303)4.21299884
17CENP-A containing nucleosome assembly (GO:0034080)4.18293956
18positive regulation of chromosome segregation (GO:0051984)4.12287959
19mitotic chromosome condensation (GO:0007076)4.10958203
20protein targeting to Golgi (GO:0000042)4.09986215
21mitotic nuclear envelope disassembly (GO:0007077)4.08445109
22chromatin remodeling at centromere (GO:0031055)4.04990475
23nucleobase biosynthetic process (GO:0046112)3.99628229
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.95150535
25spindle checkpoint (GO:0031577)3.93514268
26early endosome to late endosome transport (GO:0045022)3.93225699
27nuclear pore organization (GO:0006999)3.91347942
28DNA replication-independent nucleosome assembly (GO:0006336)3.90010562
29DNA replication-independent nucleosome organization (GO:0034724)3.90010562
30ribosome biogenesis (GO:0042254)3.88706586
31phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.85965093
32DNA replication initiation (GO:0006270)3.85527664
33establishment of protein localization to Golgi (GO:0072600)3.84119672
34histone mRNA catabolic process (GO:0071044)3.81417676
35mitotic sister chromatid segregation (GO:0000070)3.81212221
36nuclear envelope disassembly (GO:0051081)3.79521228
37membrane disassembly (GO:0030397)3.79521228
38kinetochore organization (GO:0051383)3.79484437
39nuclear pore complex assembly (GO:0051292)3.78700980
40non-recombinational repair (GO:0000726)3.76338663
41double-strand break repair via nonhomologous end joining (GO:0006303)3.76338663
42mitotic spindle checkpoint (GO:0071174)3.71352714
43regulation of chromosome segregation (GO:0051983)3.69732995
44negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.68865475
45histone exchange (GO:0043486)3.68770081
46retrograde transport, vesicle recycling within Golgi (GO:0000301)3.68673725
47maturation of 5.8S rRNA (GO:0000460)3.67240041
48negative regulation of chromosome segregation (GO:0051985)3.66266313
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.64385651
50negative regulation of sister chromatid segregation (GO:0033046)3.64385651
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.64385651
52negative regulation of mitotic sister chromatid segregation (GO:0033048)3.64385651
53DNA integration (GO:0015074)3.62635200
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.61619689
55protein localization to chromosome (GO:0034502)3.61262607
56cellular response to ethanol (GO:0071361)3.60639720
57maturation of SSU-rRNA (GO:0030490)3.60612126
58regulation of mitotic metaphase/anaphase transition (GO:0030071)3.58013178
59spindle assembly checkpoint (GO:0071173)3.57714536
60mitotic spindle assembly checkpoint (GO:0007094)3.56418858
61regulation of centriole replication (GO:0046599)3.55770006
62protein K6-linked ubiquitination (GO:0085020)3.55508410
63kinetochore assembly (GO:0051382)3.52845589
64rRNA modification (GO:0000154)3.43564194
65sister chromatid segregation (GO:0000819)3.43190182
66monoubiquitinated protein deubiquitination (GO:0035520)3.42940904
67DNA strand elongation involved in DNA replication (GO:0006271)3.41893726
68termination of RNA polymerase I transcription (GO:0006363)3.38493331
69establishment of integrated proviral latency (GO:0075713)3.35596708
70DNA replication-dependent nucleosome organization (GO:0034723)3.34282796
71DNA replication-dependent nucleosome assembly (GO:0006335)3.34282796
72transcription elongation from RNA polymerase I promoter (GO:0006362)3.34059572
73regulation of mitotic sister chromatid separation (GO:0010965)3.33761511
74regulation of mitotic sister chromatid segregation (GO:0033047)3.33761511
75regulation of sister chromatid segregation (GO:0033045)3.33761511
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31330229
77hepatocyte apoptotic process (GO:0097284)3.30352614
78Golgi to endosome transport (GO:0006895)3.28226818
79DNA strand elongation (GO:0022616)3.27977572
80V(D)J recombination (GO:0033151)3.27554114
81formation of translation preinitiation complex (GO:0001731)3.25363523
82regulation of sister chromatid cohesion (GO:0007063)3.24880479
837-methylguanosine mRNA capping (GO:0006370)3.23642057
84neural tube formation (GO:0001841)3.21813918
85histone monoubiquitination (GO:0010390)3.21783587
86DNA topological change (GO:0006265)3.18431533
87chromosome segregation (GO:0007059)3.18252799
88NLS-bearing protein import into nucleus (GO:0006607)3.17370482
89ribonucleoprotein complex biogenesis (GO:0022613)3.16423725
907-methylguanosine RNA capping (GO:0009452)3.16422382
91RNA capping (GO:0036260)3.16422382
92histone H2A monoubiquitination (GO:0035518)3.15004785
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14970682
94nuclear envelope organization (GO:0006998)3.14326747
95rRNA processing (GO:0006364)3.13873817
96regulation of DNA endoreduplication (GO:0032875)3.13158434
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.12234278
98termination of RNA polymerase III transcription (GO:0006386)3.11379686
99transcription elongation from RNA polymerase III promoter (GO:0006385)3.11379686
100regulation of centrosome cycle (GO:0046605)3.11184083
101histone mRNA metabolic process (GO:0008334)3.09278350
102transcription from RNA polymerase I promoter (GO:0006360)3.09150661
103meiotic chromosome segregation (GO:0045132)3.08965124
104spliceosomal snRNP assembly (GO:0000387)3.08846603
105negative regulation of DNA-templated transcription, elongation (GO:0032785)3.08245420
106negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.08245420
107positive regulation of mitotic sister chromatid separation (GO:1901970)3.07622686
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07622686
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07622686
110pore complex assembly (GO:0046931)3.07451623
111histone ubiquitination (GO:0016574)3.05148441
112rRNA metabolic process (GO:0016072)3.05012000
113regulation of RNA export from nucleus (GO:0046831)3.04392223
114positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04020614
115regulation of exit from mitosis (GO:0007096)3.01832989
116histone-serine phosphorylation (GO:0035404)3.01796432
117folic acid metabolic process (GO:0046655)3.01480679
118positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00444862
119ATP-dependent chromatin remodeling (GO:0043044)3.00377136
120transcription initiation from RNA polymerase I promoter (GO:0006361)2.99677972
121rRNA methylation (GO:0031167)2.99517623
122telomere maintenance via semi-conservative replication (GO:0032201)2.96884549
123microtubule depolymerization (GO:0007019)2.96021732
124chromatin assembly or disassembly (GO:0006333)2.94985894
125telomere maintenance via recombination (GO:0000722)2.94820057
126DNA unwinding involved in DNA replication (GO:0006268)2.93708727
127mitotic recombination (GO:0006312)2.93599465
128lymphoid progenitor cell differentiation (GO:0002320)2.93315247
129sister chromatid cohesion (GO:0007062)2.91931122
130negative regulation of mitosis (GO:0045839)2.90919029
131somatic cell DNA recombination (GO:0016444)2.88849236
132somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.88849236
133histone H3-K9 methylation (GO:0051567)2.87444071
134somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.86214707
135isotype switching (GO:0045190)2.86214707
136somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.86214707
137nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.85452517
138proline biosynthetic process (GO:0006561)2.84390058
139dosage compensation (GO:0007549)2.81431407
140regulation of response to tumor cell (GO:0002834)2.77449485
141positive regulation of response to tumor cell (GO:0002836)2.77449485
142positive regulation of immune response to tumor cell (GO:0002839)2.77449485
143regulation of immune response to tumor cell (GO:0002837)2.77449485
144ether lipid metabolic process (GO:0046485)2.76757554
145regulation of histone H3-K27 methylation (GO:0061085)2.76681925
146somatic recombination of immunoglobulin gene segments (GO:0016447)2.76179777
147histone H2A ubiquitination (GO:0033522)2.75881549
148IMP metabolic process (GO:0046040)2.75525405
149positive regulation of mRNA 3-end processing (GO:0031442)2.73797537
150histone H3-K36 demethylation (GO:0070544)2.72942863
151cullin deneddylation (GO:0010388)2.69913808
152COPII vesicle coating (GO:0048208)2.65270397
153somatic diversification of immune receptors (GO:0002200)2.64967532
154protein localization to Golgi apparatus (GO:0034067)2.64203196
155mitochondrial DNA replication (GO:0006264)2.63829863
156cell wall macromolecule catabolic process (GO:0016998)2.61004681
157response to X-ray (GO:0010165)2.60848237
158pre-miRNA processing (GO:0031054)2.58171277
159IMP biosynthetic process (GO:0006188)2.57449688
160regulation of translation in response to stress (GO:0043555)2.56859653
161regulation of Rac protein signal transduction (GO:0035020)2.50819672
162positive regulation of mRNA processing (GO:0050685)2.48482175
163positive regulation of histone methylation (GO:0031062)2.48135732
164negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.47975968
165regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.47896152
166detection of molecule of bacterial origin (GO:0032490)2.47689621
167regulation of centrosome duplication (GO:0010824)2.45971785
168negative regulation of T-helper cell differentiation (GO:0045623)2.45665457
169negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.45665457
170regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.45041339
171somatic diversification of immunoglobulins (GO:0016445)2.44574663
172protein localization to microtubule (GO:0035372)2.44527977
173mitotic G2 DNA damage checkpoint (GO:0007095)2.43300428
174negative regulation of DNA repair (GO:0045738)2.42847571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.05380629
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.16706706
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91227743
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.69789557
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.57316147
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46201234
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.13643656
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.11603137
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.03139507
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.97379122
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.97044027
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88642879
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.87798782
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82845429
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72339793
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68130995
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67118177
18AR_21909140_ChIP-Seq_LNCAP_Human2.63238062
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62366564
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57665724
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47377265
22* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46039663
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45185119
24VDR_23849224_ChIP-Seq_CD4+_Human2.41975946
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39786390
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22844795
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18494922
28XRN2_22483619_ChIP-Seq_HELA_Human2.10613522
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.06839736
30FOXP3_21729870_ChIP-Seq_TREG_Human2.02956981
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01391226
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95070261
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94005503
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91978145
35GABP_19822575_ChIP-Seq_HepG2_Human1.91760937
36IGF1R_20145208_ChIP-Seq_DFB_Human1.90645442
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89122867
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.87729675
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87425418
40DCP1A_22483619_ChIP-Seq_HELA_Human1.85904006
41FUS_26573619_Chip-Seq_HEK293_Human1.81442213
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80326949
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80259936
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.79672681
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78540991
46GATA1_22025678_ChIP-Seq_K562_Human1.77921239
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71540453
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.71126373
49ELK1_19687146_ChIP-ChIP_HELA_Human1.69874847
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68461918
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.63907517
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62793300
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62310205
54KDM5A_27292631_Chip-Seq_BREAST_Human1.61220971
55TTF2_22483619_ChIP-Seq_HELA_Human1.58475362
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.54475019
57CIITA_25753668_ChIP-Seq_RAJI_Human1.53951273
58EWS_26573619_Chip-Seq_HEK293_Human1.53439335
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53138328
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51714675
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50997700
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48932353
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47949548
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45267844
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45240948
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44669324
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38513040
68ER_23166858_ChIP-Seq_MCF-7_Human1.37775510
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.36252780
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35577447
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.34277393
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33926506
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.32657498
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32263735
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32179857
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31529814
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.31325166
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28804518
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28120809
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27465250
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24182277
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21628594
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21476341
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20503052
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19781747
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19693186
87TAF15_26573619_Chip-Seq_HEK293_Human1.17791946
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17658395
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16344816
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16239823
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15351390
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14924543
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14917335
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14400353
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12850484
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12818024
97SALL4_22934838_ChIP-ChIP_CD34+_Human1.10194658
98MYC_22102868_ChIP-Seq_BL_Human1.09802720
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09462319
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.09277590
101* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09004934
102BRD4_25478319_ChIP-Seq_HGPS_Human1.08620272
103TFEB_21752829_ChIP-Seq_HELA_Human1.08529676
104ELF5_23300383_ChIP-Seq_T47D_Human1.08519746
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07761801
106* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07611162
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07601535
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07428775
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05671650
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.05529973
111* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05389914
112CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04448065
113P300_19829295_ChIP-Seq_ESCs_Human1.04043730
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.03555358
115MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03148865
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03114253
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02685282
118IRF8_21731497_ChIP-ChIP_J774_Mouse1.02631300
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02552171
120IRF1_19129219_ChIP-ChIP_H3396_Human1.02445903
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02154194
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01589937
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00419224
124RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99667485
125AHR_22903824_ChIP-Seq_MCF-7_Human0.99236855
126SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98653194
127MYC_18940864_ChIP-ChIP_HL60_Human0.98583444
128NANOG_21062744_ChIP-ChIP_HESCs_Human0.97778789
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97624394
130NMYC_18555785_Chip-Seq_ESCs_Mouse0.96800363
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96752407
132P300_18555785_Chip-Seq_ESCs_Mouse0.96549272
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.95634959
134* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95340420
135SPI1_23547873_ChIP-Seq_NB4_Human0.94792981
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93794540
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93124049
138ELK1_22589737_ChIP-Seq_MCF10A_Human0.92559909
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.92431949
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91663795
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90219842
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90165978
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90165978
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89026985
145KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87494841
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87224728
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85769446
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84924135
149SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84214319
150CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81890932
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79154663
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75608209
153NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73691095
154KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72560118
155SOX17_20123909_ChIP-Seq_XEN_Mouse0.71579950
156PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71430949
157* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70576246
158KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68225336
159MYB_26560356_Chip-Seq_TH1_Human0.66898507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.89707812
2MP0003111_abnormal_nucleus_morphology4.84509452
3MP0010094_abnormal_chromosome_stability4.72400292
4MP0000569_abnormal_digit_pigmentation4.25005643
5MP0003077_abnormal_cell_cycle4.24138335
6MP0004957_abnormal_blastocyst_morpholog4.19871289
7MP0003787_abnormal_imprinting4.15898062
8MP0002009_preneoplasia4.03700446
9MP0008057_abnormal_DNA_replication3.70973642
10MP0003718_maternal_effect3.58632110
11MP0008058_abnormal_DNA_repair3.15927223
12MP0008007_abnormal_cellular_replicative2.86528090
13MP0002166_altered_tumor_susceptibility2.66506754
14MP0008932_abnormal_embryonic_tissue2.59790828
15MP0008877_abnormal_DNA_methylation2.59362347
16MP0002877_abnormal_melanocyte_morpholog2.56102330
17MP0001730_embryonic_growth_arrest2.39838119
18MP0002006_tumorigenesis2.30373270
19MP0003123_paternal_imprinting2.23777043
20MP0000350_abnormal_cell_proliferation2.18298261
21MP0003786_premature_aging2.17203022
22MP0010307_abnormal_tumor_latency2.15726734
23MP0010234_abnormal_vibrissa_follicle2.13566889
24MP0004264_abnormal_extraembryonic_tissu1.95649549
25MP0008260_abnormal_autophagy1.94857656
26MP0001672_abnormal_embryogenesis/_devel1.84769128
27MP0005380_embryogenesis_phenotype1.84769128
28MP0003300_gastrointestinal_ulcer1.83712153
29MP0002396_abnormal_hematopoietic_system1.79135850
30MP0005083_abnormal_biliary_tract1.73478649
31MP0000427_abnormal_hair_cycle1.63296739
32MP0010678_abnormal_skin_adnexa1.62339373
33MP0009333_abnormal_splenocyte_physiolog1.62217004
34MP0001697_abnormal_embryo_size1.61878897
35MP0003984_embryonic_growth_retardation1.59383551
36MP0002088_abnormal_embryonic_growth/wei1.53917135
37MP0002210_abnormal_sex_determination1.51576353
38MP0002080_prenatal_lethality1.48373559
39MP0005451_abnormal_body_composition1.47266230
40MP0009697_abnormal_copulation1.45270598
41MP0001929_abnormal_gametogenesis1.43227261
42MP0003763_abnormal_thymus_physiology1.42873048
43MP0002085_abnormal_embryonic_tissue1.42800222
44MP0006072_abnormal_retinal_apoptosis1.41367073
45MP0006292_abnormal_olfactory_placode1.40010853
46MP0002928_abnormal_bile_duct1.34343823
47MP0000313_abnormal_cell_death1.33561798
48MP0000371_diluted_coat_color1.33068282
49MP0000490_abnormal_crypts_of1.32654742
50MP0002084_abnormal_developmental_patter1.30663596
51MP0002019_abnormal_tumor_incidence1.29693433
52MP0001529_abnormal_vocalization1.29236646
53MP0000383_abnormal_hair_follicle1.28796833
54MP0000653_abnormal_sex_gland1.26297249
55MP0001145_abnormal_male_reproductive1.26252477
56MP0005395_other_phenotype1.25486798
57MP0002086_abnormal_extraembryonic_tissu1.25140575
58MP0003122_maternal_imprinting1.24596977
59MP0001119_abnormal_female_reproductive1.24486833
60MP0003567_abnormal_fetal_cardiomyocyte1.23822977
61MP0004808_abnormal_hematopoietic_stem1.17429845
62MP0005085_abnormal_gallbladder_physiolo1.16770314
63MP0005379_endocrine/exocrine_gland_phen1.16394478
64MP0001727_abnormal_embryo_implantation1.16264168
65MP0002398_abnormal_bone_marrow1.13651934
66MP0003315_abnormal_perineum_morphology1.12310749
67MP0003252_abnormal_bile_duct1.10483181
68MP0005075_abnormal_melanosome_morpholog1.10132675
69MP0003221_abnormal_cardiomyocyte_apopto1.06180734
70MP0005397_hematopoietic_system_phenotyp1.04606721
71MP0001545_abnormal_hematopoietic_system1.04606721
72MP0003121_genomic_imprinting1.04353664
73MP0003868_abnormal_feces_composition1.04316754
74MP0000703_abnormal_thymus_morphology1.03846801
75MP0002722_abnormal_immune_system1.02825357
76MP0006054_spinal_hemorrhage1.01637970
77MP0005671_abnormal_response_to1.01125919
78MP0003699_abnormal_female_reproductive1.00948290
79MP0003937_abnormal_limbs/digits/tail_de1.00696949
80MP0010352_gastrointestinal_tract_polyps1.00425411
81MP0001293_anophthalmia0.99935597
82MP0000689_abnormal_spleen_morphology0.98522028
83MP0003724_increased_susceptibility_to0.97475348
84MP0003943_abnormal_hepatobiliary_system0.95204837
85MP0004233_abnormal_muscle_weight0.94959960
86MP0002653_abnormal_ependyma_morphology0.91520448
87MP0002102_abnormal_ear_morphology0.90409276
88MP0001186_pigmentation_phenotype0.89648257
89MP0004197_abnormal_fetal_growth/weight/0.89201327
90MP0005084_abnormal_gallbladder_morpholo0.87177240
91MP0005310_abnormal_salivary_gland0.86720000
92MP0003950_abnormal_plasma_membrane0.86556922
93MP0002429_abnormal_blood_cell0.85215112
94MP0005621_abnormal_cell_physiology0.83396063
95MP0001849_ear_inflammation0.81692850
96MP0001661_extended_life_span0.81692728
97MP0004883_abnormal_blood_vessel0.81657393
98MP0000716_abnormal_immune_system0.81602408
99MP0005389_reproductive_system_phenotype0.80385369
100MP0003941_abnormal_skin_development0.79922668
101MP0003191_abnormal_cellular_cholesterol0.79158722
102MP0005384_cellular_phenotype0.77635508
103MP0004381_abnormal_hair_follicle0.77524075
104MP0002233_abnormal_nose_morphology0.76608609
105MP0003091_abnormal_cell_migration0.76315957
106MP0002168_other_aberrant_phenotype0.74872547
107MP0002161_abnormal_fertility/fecundity0.73764976
108MP0002751_abnormal_autonomic_nervous0.73357118
109MP0002075_abnormal_coat/hair_pigmentati0.72893288
110MP0002234_abnormal_pharynx_morphology0.72496480
111MP0000377_abnormal_hair_follicle0.72392543
112MP0000428_abnormal_craniofacial_morphol0.71428581
113MP0001915_intracranial_hemorrhage0.71294140
114MP0009672_abnormal_birth_weight0.71102079
115MP0008961_abnormal_basal_metabolism0.70967471
116MP0001666_abnormal_nutrient_absorption0.69652329
117MP0001800_abnormal_humoral_immune0.69380336
118MP0002092_abnormal_eye_morphology0.68968972
119MP0000858_altered_metastatic_potential0.68513960
120MP0006035_abnormal_mitochondrial_morpho0.68452477
121MP0003656_abnormal_erythrocyte_physiolo0.68225501
122MP0003890_abnormal_embryonic-extraembry0.67692144
123MP0002160_abnormal_reproductive_system0.67368285
124MP0005408_hypopigmentation0.66975983
125MP0002332_abnormal_exercise_endurance0.66652951
126MP0005253_abnormal_eye_physiology0.66341018
127MP0002420_abnormal_adaptive_immunity0.65638778
128MP0002132_abnormal_respiratory_system0.65374139
129MP0000358_abnormal_cell_content/0.65174339
130MP0005076_abnormal_cell_differentiation0.65114481
131MP0001819_abnormal_immune_cell0.65051660
132MP0002452_abnormal_antigen_presenting0.63540109
133MP0000465_gastrointestinal_hemorrhage0.63484344
134MP0003806_abnormal_nucleotide_metabolis0.63323770
135MP0009840_abnormal_foam_cell0.61962741
136MP0000566_synostosis0.61578680
137MP0010030_abnormal_orbit_morphology0.61532429
138MP0003448_altered_tumor_morphology0.61174800
139MP0002723_abnormal_immune_serum0.60022472
140MP0001835_abnormal_antigen_presentation0.58470099
141MP0001919_abnormal_reproductive_system0.58278690
142MP0000627_abnormal_mammary_gland0.58009585
143MP0000733_abnormal_muscle_development0.57895941
144MP0003698_abnormal_male_reproductive0.57127889
145MP0009703_decreased_birth_body0.56510145
146MP0003186_abnormal_redox_activity0.55994637
147MP0001542_abnormal_bone_strength0.55726848
148MP0005023_abnormal_wound_healing0.53850650

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.20981987
2Breast hypoplasia (HP:0003187)4.78612326
3Papillary thyroid carcinoma (HP:0002895)4.46228983
4Impulsivity (HP:0100710)4.32806440
5Chromsome breakage (HP:0040012)4.13520564
6Patellar aplasia (HP:0006443)4.05000068
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.97822682
8Aplasia/Hypoplasia of the patella (HP:0006498)3.90754146
9Carpal bone hypoplasia (HP:0001498)3.71948454
10Cerebral hypomyelination (HP:0006808)3.54397142
11Premature ovarian failure (HP:0008209)3.39202024
12Thyroid carcinoma (HP:0002890)3.20415579
13Abnormality of the labia minora (HP:0012880)3.18055964
14Abnormality of chromosome stability (HP:0003220)3.16709644
15Biliary tract neoplasm (HP:0100574)3.14913142
16Degeneration of anterior horn cells (HP:0002398)3.10099899
17Abnormality of the anterior horn cell (HP:0006802)3.10099899
18Rough bone trabeculation (HP:0100670)3.00001945
19T lymphocytopenia (HP:0005403)2.96275800
20Absent radius (HP:0003974)2.96233934
21Abnormality of the preputium (HP:0100587)2.91735099
22Muscle hypertrophy of the lower extremities (HP:0008968)2.90418400
23Meckel diverticulum (HP:0002245)2.89184548
24Nephroblastoma (Wilms tumor) (HP:0002667)2.85976748
25Entropion (HP:0000621)2.82276505
26Absent forearm bone (HP:0003953)2.81729879
27Aplasia involving forearm bones (HP:0009822)2.81729879
28Secondary amenorrhea (HP:0000869)2.81264359
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.78252220
30Menstrual irregularities (HP:0000858)2.77492678
31Ureteral duplication (HP:0000073)2.77481301
32Subacute progressive viral hepatitis (HP:0006572)2.76067483
33Curly hair (HP:0002212)2.75013907
34Abnormality of the ileum (HP:0001549)2.74263736
35Abnormal biliary tract morphology (HP:0012440)2.71183359
36Deep philtrum (HP:0002002)2.71067958
37Facial hemangioma (HP:0000329)2.70176544
38Gastrointestinal carcinoma (HP:0002672)2.64948898
39Malignant gastrointestinal tract tumors (HP:0006749)2.64948898
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.64502848
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.64014705
42Termporal pattern (HP:0011008)2.62598138
43Insidious onset (HP:0003587)2.62598138
44Pancreatic islet-cell hyperplasia (HP:0004510)2.62408215
45Selective tooth agenesis (HP:0001592)2.62145152
46Duodenal stenosis (HP:0100867)2.62017866
47Small intestinal stenosis (HP:0012848)2.62017866
48Abnormality of methionine metabolism (HP:0010901)2.61898254
49Oral leukoplakia (HP:0002745)2.59669714
50Hematochezia (HP:0002573)2.58274686
51Reticulocytopenia (HP:0001896)2.58011004
52Myelodysplasia (HP:0002863)2.56949327
53Embryonal renal neoplasm (HP:0011794)2.56605712
54Abnormality of T cell number (HP:0011839)2.54625851
55Gonadotropin excess (HP:0000837)2.51757155
56Sloping forehead (HP:0000340)2.49743540
57Oligodactyly (HP:0012165)2.46379808
58Bladder neoplasm (HP:0009725)2.44501487
59Bladder carcinoma (HP:0002862)2.44501487
60Renal cortical cysts (HP:0000803)2.41939923
61Oligodactyly (hands) (HP:0001180)2.41636667
62Prominent nose (HP:0000448)2.41126936
63Transitional cell carcinoma of the bladder (HP:0006740)2.40973164
64Ectopic kidney (HP:0000086)2.40775271
65Cystic hygroma (HP:0000476)2.40594760
66Neoplasm of striated muscle (HP:0009728)2.40267065
67Flat capital femoral epiphysis (HP:0003370)2.38329256
68Lower limb hyperreflexia (HP:0002395)2.35246880
69Bone marrow hypocellularity (HP:0005528)2.33435990
70Supernumerary spleens (HP:0009799)2.32068100
71Abnormality of the musculature of the pelvis (HP:0001469)2.30799880
72Abnormality of the hip-girdle musculature (HP:0001445)2.30799880
73Irregular epiphyses (HP:0010582)2.30614687
74Aplasia/Hypoplasia of the sternum (HP:0006714)2.26844268
75Abnormality of the left ventricular outflow tract (HP:0011103)2.25990316
76Subaortic stenosis (HP:0001682)2.25990316
77Overlapping toe (HP:0001845)2.25867819
78Neoplasm of the small intestine (HP:0100833)2.25252987
79Abnormality of the astrocytes (HP:0100707)2.23958278
80Astrocytoma (HP:0009592)2.23958278
81Disinhibition (HP:0000734)2.23483444
82Abnormal spermatogenesis (HP:0008669)2.20802404
83Ependymoma (HP:0002888)2.20455132
84Abnormal trabecular bone morphology (HP:0100671)2.20280707
85Absent frontal sinuses (HP:0002688)2.18542368
86Abnormality of the proximal phalanges of the hand (HP:0009834)2.18330935
87CNS hypomyelination (HP:0003429)2.18191797
88Drooling (HP:0002307)2.17407918
89Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.16822988
90Capillary hemangiomas (HP:0005306)2.16815122
91Uterine leiomyosarcoma (HP:0002891)2.16547953
92Leiomyosarcoma (HP:0100243)2.16547953
93Abnormal lung lobation (HP:0002101)2.15346088
94Absent epiphyses (HP:0010577)2.14371550
95Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.14371550
96Pelvic girdle muscle weakness (HP:0003749)2.13620285
97Abnormality of the duodenum (HP:0002246)2.12694512
98Absent thumb (HP:0009777)2.12475752
99Horseshoe kidney (HP:0000085)2.12117997
100Abnormality of endocrine pancreas physiology (HP:0012093)2.11609667
101Abnormality of the pancreatic islet cells (HP:0006476)2.11609667
102Exercise-induced muscle cramps (HP:0003710)2.10972344
103Inappropriate behavior (HP:0000719)2.10965152
104Sex reversal (HP:0012245)2.10453224
105Abnormal sex determination (HP:0012244)2.10453224
106Limb hypertonia (HP:0002509)2.10199301
107Abnormality of the umbilical cord (HP:0010881)2.09505038
108Excessive salivation (HP:0003781)2.09451921
109Duplicated collecting system (HP:0000081)2.08630917
110Testicular neoplasm (HP:0010788)2.07663535
111Thickened calvaria (HP:0002684)2.07518065
112Hyperglycinemia (HP:0002154)2.05973857
113Abnormal auditory evoked potentials (HP:0006958)2.05938950
114Cutis marmorata (HP:0000965)2.05863347
115Short thumb (HP:0009778)2.05541515
116Uterine neoplasm (HP:0010784)2.05176088
117Microretrognathia (HP:0000308)2.05152890
118Neoplasm of the pancreas (HP:0002894)2.04705493
119Recurrent bacterial skin infections (HP:0005406)2.04657840
120Cellular immunodeficiency (HP:0005374)2.04566895
121Premature graying of hair (HP:0002216)2.03563267
122Abnormal foot bone ossification (HP:0010675)2.03198764
123Sparse lateral eyebrow (HP:0005338)2.03002997
124Colon cancer (HP:0003003)2.01876027
125Multiple enchondromatosis (HP:0005701)2.00895830
126Breast aplasia (HP:0100783)1.99626353
127Cleft eyelid (HP:0000625)1.99571222
128Medulloblastoma (HP:0002885)1.99069140
129Bifid tongue (HP:0010297)1.99056918
130IgG deficiency (HP:0004315)1.97969068
131Atresia of the external auditory canal (HP:0000413)1.97029929
132Aplastic anemia (HP:0001915)1.96287670
133Freckling (HP:0001480)1.95150345
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.94974663
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94974663
136Hypochromic microcytic anemia (HP:0004840)1.94528668
137Male infertility (HP:0003251)1.94455047
138Volvulus (HP:0002580)1.94287897
139Thyroiditis (HP:0100646)1.93723586
140Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93599234
141Upper motor neuron abnormality (HP:0002127)1.92821829
142Breast carcinoma (HP:0003002)1.92071290
143Aplasia/Hypoplasia of the breasts (HP:0010311)1.91405719
144Neoplasm of the thyroid gland (HP:0100031)1.90734438
145Abnormal hair whorl (HP:0010721)1.90554719
146Progressive external ophthalmoplegia (HP:0000590)1.90519086
147Atrophy/Degeneration involving motor neurons (HP:0007373)1.90509516
148Small epiphyses (HP:0010585)1.90500646
149Abnormality of DNA repair (HP:0003254)1.89579349
150Pustule (HP:0200039)1.88596392
151Scanning speech (HP:0002168)1.88245030
152Glioma (HP:0009733)1.87526285
153Rhabdomyosarcoma (HP:0002859)1.86559775
154Hepatoblastoma (HP:0002884)1.86401261
155Agnosia (HP:0010524)1.85965822
156Deformed tarsal bones (HP:0008119)1.85902085
157Abnormality of the corticospinal tract (HP:0002492)1.85145697
158Aplasia/Hypoplasia involving the musculature (HP:0001460)1.84908192
159Abnormality of the fingertips (HP:0001211)1.84880147
160Squamous cell carcinoma (HP:0002860)1.84558169
161IgM deficiency (HP:0002850)1.83988278
162Abnormality of the parathyroid morphology (HP:0011766)1.83727451
163Gonadal dysgenesis (HP:0000133)1.83491080
164Microglossia (HP:0000171)1.83254776
165Proximal placement of thumb (HP:0009623)1.83115362
166Abnormality of lateral ventricle (HP:0030047)1.82695986
167Recurrent abscess formation (HP:0002722)1.82691926
168Clubbing of toes (HP:0100760)1.82374105
169Type 2 muscle fiber atrophy (HP:0003554)1.82260595
170Triphalangeal thumb (HP:0001199)1.82193428
171Low anterior hairline (HP:0000294)1.81232183
172Smooth philtrum (HP:0000319)1.80581771
173Stillbirth (HP:0003826)1.79935889
174Slender long bone (HP:0003100)1.79743255
175Neoplasm of the rectum (HP:0100743)1.79654704
176Blepharitis (HP:0000498)1.78973835
177Deviation of the thumb (HP:0009603)1.78964613
178Combined immunodeficiency (HP:0005387)1.76940202
179Spinal muscular atrophy (HP:0007269)1.76734085
180Lymphoma (HP:0002665)1.76712226
181Pheochromocytoma (HP:0002666)1.75801668
182Tracheoesophageal fistula (HP:0002575)1.75211835
183Nemaline bodies (HP:0003798)1.74262200
184Ovarian neoplasm (HP:0100615)1.73248537
185Barrel-shaped chest (HP:0001552)1.72674571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.84462946
2WEE14.24530845
3CDC73.39000757
4EIF2AK13.17873904
5NEK23.12174152
6PLK43.10119828
7BRSK23.06352272
8ERBB33.06349791
9TTK2.74572023
10TAF12.52762053
11SRPK12.44457869
12ACVR1B2.31768130
13PLK12.31681712
14TSSK62.31203611
15SCYL22.27683655
16TRIM282.26401847
17PLK32.04925096
18TRPM71.97050084
19BRSK11.94267352
20AURKB1.78854334
21CHEK21.73732913
22MKNK21.72587389
23DYRK31.72537474
24BCR1.66609727
25MAP3K41.65121923
26MKNK11.65088123
27MELK1.64380282
28NEK11.62330265
29EIF2AK31.58504961
30STK101.57624657
31MAP3K141.50894722
32TNIK1.50216940
33TESK21.49900576
34YES11.45488013
35ATR1.35496244
36CCNB11.35121500
37STK31.34557037
38STK161.33590172
39STK38L1.33522500
40VRK11.28729036
41FGR1.26927301
42CHEK11.25893546
43CDK71.25485878
44RPS6KA41.24120637
45TGFBR21.22834434
46CDK41.21979357
47BRAF1.20513204
48AURKA1.18262251
49MAP3K81.17150320
50ZAK1.15188261
51NME21.14412624
52BMPR1B1.13616474
53LATS11.11866700
54STK391.09417830
55FGFR31.05342008
56CAMKK21.03364270
57MAP2K70.98018189
58FER0.97032328
59SGK20.96743335
60MST40.96386497
61SGK30.96252149
62CDK120.91860765
63TLK10.91516567
64PIK3CA0.86970306
65AKT30.86053155
66SIK30.85722802
67WNK30.84818029
68NUAK10.84618262
69PIM10.83572271
70IRAK10.82182698
71ATM0.81637357
72RPS6KB20.80771527
73CDK20.80543470
74EIF2AK20.80122732
75GRK70.80059753
76LATS20.79252952
77OXSR10.79098123
78MARK30.79010793
79CDK80.78637654
80STK40.77754003
81PASK0.77582958
82MAP4K10.76435829
83KSR10.74260213
84PDK40.72817449
85PDK30.72817449
86EPHA20.69162272
87CASK0.68976103
88PDK20.68310631
89PKN20.67494388
90CDK10.66788031
91MOS0.66676485
92MAP3K100.65924092
93RPS6KB10.65565688
94PRKCI0.64792224
95TXK0.63380202
96CAMK1G0.63344930
97FGFR10.62028026
98STK240.61067441
99PAK30.60549696
100FRK0.59463292
101PAK10.59101325
102OBSCN0.58825140
103EGFR0.57778282
104ALK0.56479761
105JAK20.55593333
106CSNK2A10.54559182
107CSNK2A20.54195106
108RPS6KA50.53836835
109DYRK20.53540556
110MAP3K60.53342751
111MAP3K20.52298120
112RAF10.51692384
113EEF2K0.50494584
114PNCK0.49853525
115TYK20.49272831
116CSNK1G30.48790087
117PIM20.48445457
118NME10.48024900
119PBK0.47772525
120CDK90.46607957
121CSK0.46191829
122IRAK40.45800830
123JAK10.45502112
124ARAF0.44513292
125LIMK10.43707178
126NEK90.43623679
127CDK60.43442033
128ZAP700.39845857
129CSNK1G10.38701049
130NLK0.36604631
131BMPR20.36282319
132MAP3K50.36081783
133NEK60.34219837
134CDK30.34131526
135CHUK0.32944155
136CLK10.32496166
137CSNK1E0.31951986
138BRD40.29094864
139TEC0.28382312
140CSNK1A1L0.27805027
141JAK30.26694606
142TAOK30.26068599
143BLK0.23466273
144TGFBR10.23238213
145MTOR0.23141961
146KDR0.22752062

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.29909426
2RNA polymerase_Homo sapiens_hsa030203.95510123
3Vitamin B6 metabolism_Homo sapiens_hsa007503.67519221
4DNA replication_Homo sapiens_hsa030303.65669911
5RNA transport_Homo sapiens_hsa030133.32883222
6Cell cycle_Homo sapiens_hsa041103.23488893
7Mismatch repair_Homo sapiens_hsa034303.09612837
8Proteasome_Homo sapiens_hsa030503.05396925
9* Spliceosome_Homo sapiens_hsa030403.00245951
10Basal transcription factors_Homo sapiens_hsa030222.80613223
11Homologous recombination_Homo sapiens_hsa034402.79763012
12Nucleotide excision repair_Homo sapiens_hsa034202.58110361
13Base excision repair_Homo sapiens_hsa034102.54589429
14Pyrimidine metabolism_Homo sapiens_hsa002402.28732412
15Fanconi anemia pathway_Homo sapiens_hsa034602.27043942
16RNA degradation_Homo sapiens_hsa030182.14491391
17p53 signaling pathway_Homo sapiens_hsa041152.01292108
18Non-homologous end-joining_Homo sapiens_hsa034501.93411020
19Ribosome_Homo sapiens_hsa030101.79682941
20mRNA surveillance pathway_Homo sapiens_hsa030151.65978124
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65050959
22One carbon pool by folate_Homo sapiens_hsa006701.57547588
23Steroid biosynthesis_Homo sapiens_hsa001001.56640336
24Endometrial cancer_Homo sapiens_hsa052131.50039310
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48050474
26Epstein-Barr virus infection_Homo sapiens_hsa051691.45627676
27Purine metabolism_Homo sapiens_hsa002301.44223527
28Oocyte meiosis_Homo sapiens_hsa041141.33337309
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27317603
30Renal cell carcinoma_Homo sapiens_hsa052111.26945417
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24364834
32Regulation of autophagy_Homo sapiens_hsa041401.20166269
33Non-small cell lung cancer_Homo sapiens_hsa052231.17539618
34Antigen processing and presentation_Homo sapiens_hsa046121.16401002
35Folate biosynthesis_Homo sapiens_hsa007901.15007209
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14072180
37Herpes simplex infection_Homo sapiens_hsa051681.13689821
38B cell receptor signaling pathway_Homo sapiens_hsa046621.12320466
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12233455
40Prolactin signaling pathway_Homo sapiens_hsa049171.09421875
41Viral carcinogenesis_Homo sapiens_hsa052030.98398129
42Pentose phosphate pathway_Homo sapiens_hsa000300.98102029
43Adherens junction_Homo sapiens_hsa045200.91940995
44Systemic lupus erythematosus_Homo sapiens_hsa053220.89684360
45Inositol phosphate metabolism_Homo sapiens_hsa005620.88929215
46Acute myeloid leukemia_Homo sapiens_hsa052210.85318268
47Primary immunodeficiency_Homo sapiens_hsa053400.84860393
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.84135168
49Proteoglycans in cancer_Homo sapiens_hsa052050.84063557
50Insulin resistance_Homo sapiens_hsa049310.80067384
51Malaria_Homo sapiens_hsa051440.77113244
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76624583
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75883614
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75390591
55Hepatitis C_Homo sapiens_hsa051600.75207523
56Tuberculosis_Homo sapiens_hsa051520.74628055
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74544050
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73913142
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.73844752
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73160516
61MicroRNAs in cancer_Homo sapiens_hsa052060.72835313
62Osteoclast differentiation_Homo sapiens_hsa043800.71876236
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.69800675
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.69567693
65HTLV-I infection_Homo sapiens_hsa051660.69261884
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67889768
67Insulin signaling pathway_Homo sapiens_hsa049100.66250654
68Measles_Homo sapiens_hsa051620.65297112
69Selenocompound metabolism_Homo sapiens_hsa004500.62101431
70Fatty acid biosynthesis_Homo sapiens_hsa000610.61155591
71Chemokine signaling pathway_Homo sapiens_hsa040620.59375986
72Small cell lung cancer_Homo sapiens_hsa052220.56746828
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55574152
74Protein export_Homo sapiens_hsa030600.54363122
75Toxoplasmosis_Homo sapiens_hsa051450.54244207
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53893846
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.53523840
78Propanoate metabolism_Homo sapiens_hsa006400.52797419
79Wnt signaling pathway_Homo sapiens_hsa043100.52393869
80Biosynthesis of amino acids_Homo sapiens_hsa012300.52145227
81TGF-beta signaling pathway_Homo sapiens_hsa043500.52110119
82Alcoholism_Homo sapiens_hsa050340.51920617
83ErbB signaling pathway_Homo sapiens_hsa040120.51669326
84Apoptosis_Homo sapiens_hsa042100.51374093
85Endocytosis_Homo sapiens_hsa041440.51167062
86TNF signaling pathway_Homo sapiens_hsa046680.50685785
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49765264
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.49368482
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.48709310
90Peroxisome_Homo sapiens_hsa041460.48256204
91Hematopoietic cell lineage_Homo sapiens_hsa046400.48204182
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.46455205
93Circadian rhythm_Homo sapiens_hsa047100.45179188
94Glioma_Homo sapiens_hsa052140.44071976
95Legionellosis_Homo sapiens_hsa051340.43921646
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43549098
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42562471
98Hepatitis B_Homo sapiens_hsa051610.41469178
99Allograft rejection_Homo sapiens_hsa053300.40960723
100Graft-versus-host disease_Homo sapiens_hsa053320.40667132
101Thyroid cancer_Homo sapiens_hsa052160.40167559
102FoxO signaling pathway_Homo sapiens_hsa040680.39125069
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39121385
104Influenza A_Homo sapiens_hsa051640.38530464
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36653547
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35833410
107Vitamin digestion and absorption_Homo sapiens_hsa049770.35423338
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34369812
109T cell receptor signaling pathway_Homo sapiens_hsa046600.32313812
110Hippo signaling pathway_Homo sapiens_hsa043900.31684324
111Notch signaling pathway_Homo sapiens_hsa043300.29679711
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29272907
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.28512562
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28396900
115Shigellosis_Homo sapiens_hsa051310.27164856
116Colorectal cancer_Homo sapiens_hsa052100.26665582
117mTOR signaling pathway_Homo sapiens_hsa041500.25825751
118Autoimmune thyroid disease_Homo sapiens_hsa053200.24966551
119Glutathione metabolism_Homo sapiens_hsa004800.23016119
120Asthma_Homo sapiens_hsa053100.21899877
121Sulfur relay system_Homo sapiens_hsa041220.21495069
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21142026
123HIF-1 signaling pathway_Homo sapiens_hsa040660.19523029
124Leishmaniasis_Homo sapiens_hsa051400.19470023
125Pancreatic cancer_Homo sapiens_hsa052120.17820103
126Linoleic acid metabolism_Homo sapiens_hsa005910.17682385
127Prostate cancer_Homo sapiens_hsa052150.15400853
128Pathways in cancer_Homo sapiens_hsa052000.14952289
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14513352
130Chronic myeloid leukemia_Homo sapiens_hsa052200.14053395
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13978111
132Fructose and mannose metabolism_Homo sapiens_hsa000510.13890722
133Ether lipid metabolism_Homo sapiens_hsa005650.13759618
134Viral myocarditis_Homo sapiens_hsa054160.13694967
135Arachidonic acid metabolism_Homo sapiens_hsa005900.12801103
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12606362
137Metabolic pathways_Homo sapiens_hsa011000.12417061
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12309529
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10872477

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