CRNN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host (GO:0044406)9.18488157
2apical protein localization (GO:0045176)8.98630217
3peptide cross-linking (GO:0018149)8.98598525
4cell wall macromolecule catabolic process (GO:0016998)8.82200204
5cell wall macromolecule metabolic process (GO:0044036)8.82200204
6negative regulation of bone mineralization (GO:0030502)8.54639463
7citrulline biosynthetic process (GO:0019240)8.02503921
8hair follicle morphogenesis (GO:0031069)7.96768589
9negative regulation of biomineral tissue development (GO:0070168)7.60591725
10transepithelial transport (GO:0070633)7.38904274
11keratinocyte differentiation (GO:0030216)6.99735466
12hair cell differentiation (GO:0035315)6.84169749
13intermediate filament cytoskeleton organization (GO:0045104)6.77022429
14intermediate filament-based process (GO:0045103)6.54950502
15negative regulation of homotypic cell-cell adhesion (GO:0034111)6.53983493
16membrane raft organization (GO:0031579)6.50277618
17localization within membrane (GO:0051668)6.39927770
18epidermis development (GO:0008544)6.32829876
19asymmetric protein localization (GO:0008105)6.29477693
20establishment of skin barrier (GO:0061436)6.29270652
21long-chain fatty acid biosynthetic process (GO:0042759)6.24236499
22molting cycle process (GO:0022404)6.08088676
23hair cycle process (GO:0022405)6.08088676
24bundle of His cell to Purkinje myocyte communication (GO:0086069)6.03559956
25lipoxygenase pathway (GO:0019372)5.79952384
26regulation of water loss via skin (GO:0033561)5.58702960
27O-glycan processing (GO:0016266)5.54706772
28epidermal cell differentiation (GO:0009913)5.47062926
29positive regulation of endothelial cell differentiation (GO:0045603)5.39021828
30citrulline metabolic process (GO:0000052)5.27014695
31negative regulation of interleukin-17 production (GO:0032700)5.12088246
32negative regulation of cell-cell adhesion (GO:0022408)5.06690608
33positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)4.91629446
34hemidesmosome assembly (GO:0031581)4.86250945
35linoleic acid metabolic process (GO:0043651)4.81858961
36hair follicle development (GO:0001942)4.66246999
37regulation of platelet aggregation (GO:0090330)4.61887467
38eyelid development in camera-type eye (GO:0061029)4.56963410
39skin morphogenesis (GO:0043589)4.56072280
40superoxide anion generation (GO:0042554)4.50694395
41peptidyl-arginine modification (GO:0018195)4.47302036
42tooth mineralization (GO:0034505)4.39836918
43regulation of mitochondrial depolarization (GO:0051900)4.33934063
44positive regulation of p38MAPK cascade (GO:1900745)4.27252665
45negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.17618228
46epithelial cell differentiation (GO:0030855)4.16977044
47negative regulation of cytokine-mediated signaling pathway (GO:0001960)4.14039808
48negative regulation of response to cytokine stimulus (GO:0060761)3.95504511
49multicellular organismal water homeostasis (GO:0050891)3.85112349
50protein O-linked glycosylation (GO:0006493)3.69748310
51regulation of endothelial cell differentiation (GO:0045601)3.69738919
52positive regulation of chemokine biosynthetic process (GO:0045080)3.68333132
53antimicrobial humoral response (GO:0019730)3.68058808
54keratinocyte development (GO:0003334)3.67996613
55regulation of keratinocyte differentiation (GO:0045616)3.65239940
56negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.63864579
57negative regulation of keratinocyte proliferation (GO:0010839)3.63009485
58negative regulation of platelet activation (GO:0010544)3.61816437
59regulation of protein polyubiquitination (GO:1902914)3.58807119
60positive regulation of hair follicle development (GO:0051798)3.54925876
61positive regulation of hair cycle (GO:0042635)3.54925876
62regulation of cholesterol homeostasis (GO:2000188)3.54657254
63response to phenylpropanoid (GO:0080184)3.54021317
64bone trabecula formation (GO:0060346)3.51790147
65ectoderm development (GO:0007398)3.50449834
66intestinal epithelial cell development (GO:0060576)3.48193313
67negative regulation of cell-substrate adhesion (GO:0010812)3.46787996
68gap junction assembly (GO:0016264)3.45806256
69regulation of hair follicle development (GO:0051797)3.44600884
70negative regulation of interferon-gamma production (GO:0032689)3.39043822
71regulation of integrin-mediated signaling pathway (GO:2001044)3.33682436
72regulation of hair cycle (GO:0042634)3.33263290
73epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.29231924
74regulation of interleukin-17 production (GO:0032660)3.23497663
75wound healing (GO:0042060)3.23225318
76regulation of p38MAPK cascade (GO:1900744)3.21172103
77positive regulation of vasodilation (GO:0045909)3.11711414
78water homeostasis (GO:0030104)3.11448661
79defense response to fungus (GO:0050832)3.08193538
80regulation of bile acid biosynthetic process (GO:0070857)3.06112422
81hypotonic response (GO:0006971)3.05769125
82epithelium development (GO:0060429)3.04928979
83negative regulation of protein localization to plasma membrane (GO:1903077)3.04180852
84positive regulation of meiotic cell cycle (GO:0051446)3.02816868
85cranial suture morphogenesis (GO:0060363)3.02598828
86molting cycle (GO:0042303)29.6872994
87hair cycle (GO:0042633)29.6872994
88regulation of interferon-beta biosynthetic process (GO:0045357)2.99858864
89regulation of T cell migration (GO:2000404)2.90312050
90cell surface receptor signaling pathway involved in heart development (GO:0061311)2.85675939
91negative regulation of muscle cell apoptotic process (GO:0010656)2.81895336
92regulation of type 2 immune response (GO:0002828)2.80642201
93positive regulation of epidermis development (GO:0045684)2.75731995
94atrioventricular valve morphogenesis (GO:0003181)2.74261252
95Rho protein signal transduction (GO:0007266)2.73960226
96phosphatidylinositol acyl-chain remodeling (GO:0036149)2.72059925
97regulation of chemokine biosynthetic process (GO:0045073)2.68451042
98fatty acid elongation (GO:0030497)2.68215064
99ventricular cardiac muscle cell action potential (GO:0086005)2.66759729
100regulation of epidermal cell differentiation (GO:0045604)2.66419516
101cochlea morphogenesis (GO:0090103)2.65904939
102detection of bacterium (GO:0016045)2.65871890
103regulation of homotypic cell-cell adhesion (GO:0034110)2.61848857
104endosome organization (GO:0007032)2.59358612
105regulation of epidermis development (GO:0045682)2.56757265
106wound healing, spreading of epidermal cells (GO:0035313)2.56140080
107lymph node development (GO:0048535)2.56064756
108positive regulation of Cdc42 GTPase activity (GO:0043089)2.54172303
109regulation of establishment of planar polarity (GO:0090175)2.51929225
110regulation of mesenchymal cell apoptotic process (GO:2001053)2.51727691
111negative regulation of cell fate specification (GO:0009996)2.48466163
112regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.47440122
113planar cell polarity pathway involved in neural tube closure (GO:0090179)2.47157269
114positive regulation of vesicle fusion (GO:0031340)2.45190076
1153-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.39650643
116purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.39650643
117phosphatidylserine acyl-chain remodeling (GO:0036150)2.39581048
118negative regulation of epidermis development (GO:0045683)2.39308845
119chronic inflammatory response (GO:0002544)2.39259786
120Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38988503
121outflow tract septum morphogenesis (GO:0003148)2.38547676
122regulation of hippo signaling (GO:0035330)2.36989820
123early endosome to late endosome transport (GO:0045022)2.36155026
124detection of other organism (GO:0098543)2.34803347
125regulation of developmental pigmentation (GO:0048070)2.33442035
126biomineral tissue development (GO:0031214)2.33441688
127negative regulation of neurotransmitter secretion (GO:0046929)2.32815347
128chondrocyte development (GO:0002063)2.32054619
129regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30201942
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.29588998
131negative regulation of ossification (GO:0030279)2.29048954
132lymph vessel development (GO:0001945)2.28812485
133regulation of heart rate by cardiac conduction (GO:0086091)2.27909714
134positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27789359
135skin development (GO:0043588)2.27726937
136vitamin A metabolic process (GO:0006776)2.27605248
137sodium ion homeostasis (GO:0055078)2.27254387
138non-canonical Wnt signaling pathway (GO:0035567)2.25043009
139keratinocyte proliferation (GO:0043616)2.22451950
140lateral sprouting from an epithelium (GO:0060601)2.19919334
141phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.17649821
142positive regulation of epidermal cell differentiation (GO:0045606)2.16924473
143regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.15120741
144regulation of keratinocyte proliferation (GO:0010837)2.13938808
145cell communication involved in cardiac conduction (GO:0086065)2.12002744
146BMP signaling pathway (GO:0030509)2.11947321
147craniofacial suture morphogenesis (GO:0097094)2.11335411
148epithelial cell-cell adhesion (GO:0090136)2.09258741
149establishment of tissue polarity (GO:0007164)2.08871746
150establishment of planar polarity (GO:0001736)2.08871746
151regulation of cardioblast differentiation (GO:0051890)2.06641155
152regulation of cell fate specification (GO:0042659)2.06414710
153cytoskeletal anchoring at plasma membrane (GO:0007016)2.05384268
154regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.04588455
155odontogenesis of dentin-containing tooth (GO:0042475)2.04535336
156positive regulation of monocyte chemotaxis (GO:0090026)2.02089244
157cellular zinc ion homeostasis (GO:0006882)2.01722541
158keratinization (GO:0031424)11.8405255
159intermediate filament organization (GO:0045109)11.8023453
160desmosome organization (GO:0002934)11.5539725
161adhesion of symbiont to host cell (GO:0044650)10.9768642
162virion attachment to host cell (GO:0019062)10.9768642
163myotube differentiation (GO:0014902)1.92171323
164negative regulation of epidermal cell differentiation (GO:0045605)1.90715350
165coronary vasculature morphogenesis (GO:0060977)1.90224486
166phosphatidylethanolamine acyl-chain remodeling (GO:0036152)1.85367220
167regulation of secondary heart field cardioblast proliferation (GO:0003266)1.85187172
168regulation of cardioblast proliferation (GO:0003264)1.85187172
169very long-chain fatty acid metabolic process (GO:0000038)1.82147211
170phosphatidylserine metabolic process (GO:0006658)1.82104211
171cardiac epithelial to mesenchymal transition (GO:0060317)1.81177080
172odontogenesis (GO:0042476)1.81035734
173regulation of ruffle assembly (GO:1900027)1.78216516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.55312069
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.76882649
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.08423744
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.71505914
5P63_26484246_Chip-Seq_KERATINOCYTES_Human3.63803776
6VDR_22108803_ChIP-Seq_LS180_Human3.22389316
7SOX9_24532713_ChIP-Seq_HFSC_Mouse2.02376437
8TP63_17297297_ChIP-ChIP_HaCaT_Human13.1827327
9ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87243222
10FOXO3_23340844_ChIP-Seq_DLD1_Human1.84427362
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.83178420
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.83178420
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.82344605
14FOXM1_26456572_ChIP-Seq_MCF-7_Human1.77384676
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.75417170
16BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.75372733
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70342878
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69831714
19EGR1_19032775_ChIP-ChIP_M12_Human1.69638733
20CDX2_20551321_ChIP-Seq_CACO-2_Human1.64581351
21NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.64518878
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63427406
23* CTCF_20526341_ChIP-Seq_ESCs_Human1.62413736
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56551388
25AHR_22903824_ChIP-Seq_MCF-7_Human1.53507638
26ERG_20517297_ChIP-Seq_VCAP_Human1.53304947
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.53048734
28MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.50393545
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.50320163
30FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.46480975
31TAF2_19829295_ChIP-Seq_ESCs_Human1.46097789
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42505287
33P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.41629596
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40763184
35TP63_23658742_ChIP-Seq_EP156T_Human1.40102272
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39268741
37NANOG_20526341_ChIP-Seq_ESCs_Human1.37890056
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36837117
39TP53_18474530_ChIP-ChIP_U2OS_Human1.35454065
40RACK7_27058665_Chip-Seq_MCF-7_Human1.34143544
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.32526413
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32194495
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.31748444
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30978855
45P53_21459846_ChIP-Seq_SAOS-2_Human1.30921459
46TP63_22573176_ChIP-Seq_HFKS_Human1.30554294
47* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.29170595
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28855186
49* E2F1_20622854_ChIP-Seq_HELA_Human1.28765822
50AR_21572438_ChIP-Seq_LNCaP_Human1.28559210
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.27942158
52GATA3_24758297_ChIP-Seq_MCF-7_Human1.27142184
53CTCF_27219007_Chip-Seq_Bcells_Human1.25038380
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21472385
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20640481
56ATF3_27146783_Chip-Seq_COLON_Human1.20469396
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20349456
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17884641
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17547284
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16857023
61HTT_18923047_ChIP-ChIP_STHdh_Human1.16036255
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14867622
63GATA4_25053715_ChIP-Seq_YYC3_Human1.14572800
64* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14086863
65TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12857441
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12371399
67RXR_22108803_ChIP-Seq_LS180_Human1.11629830
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10532382
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10462455
70SMAD3_21741376_ChIP-Seq_HESCs_Human1.09805705
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09527540
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08862296
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08637013
74STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06943673
75* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05211264
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.04646070
77BCOR_27268052_Chip-Seq_Bcells_Human1.04409157
78SOX2_20726797_ChIP-Seq_SW620_Human1.04367517
79* KLF5_25053715_ChIP-Seq_YYC3_Human1.03229867
80BCL6_27268052_Chip-Seq_Bcells_Human1.03026869
81BCAT_22108803_ChIP-Seq_LS180_Human1.02585726
82TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01573020
83* CEBPB_22108803_ChIP-Seq_LS180_Human1.01230361
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01110658
85CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99824740
86HOXB7_26014856_ChIP-Seq_BT474_Human0.96431741
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96409716
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96367784
89YY1_22570637_ChIP-Seq_MALME-3M_Human0.96058997
90FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95957243
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95237885
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.94939340
93CJUN_26792858_Chip-Seq_BT549_Human0.94736971
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94154437
95LXR_22292898_ChIP-Seq_THP-1_Human0.93873911
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93523678
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92580105
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92235634
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92235634
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.92184182
101TBX20_22080862_ChIP-Seq_HEART_Mouse0.92184182
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92147808
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.91963180
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91647932
105ZNF263_19887448_ChIP-Seq_K562_Human0.91234034
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90645579
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90395204
108* RBPJ_21746931_ChIP-Seq_IB4_Human0.88852057
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88224301
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88108945
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.87029348
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86920245
113* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86896097
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.85456563
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.85215897
116* RUNX1_27514584_Chip-Seq_MCF-7_Human0.84509703
117E2F1_17053090_ChIP-ChIP_MCF-7_Human0.83977691
118GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83885494
119RING1B_27294783_Chip-Seq_ESCs_Mouse0.83815199
120CREB1_26743006_Chip-Seq_LNCaP_Human0.83174682
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82742136
122* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82305258
123SMC4_20622854_ChIP-Seq_HELA_Human0.81056591
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80480565
125ELF5_23300383_ChIP-Seq_T47D_Human0.80377184
126CHD1_26751641_Chip-Seq_LNCaP_Human0.79213135
127RAC3_21632823_ChIP-Seq_H3396_Human0.78682511
128PHF8_20622854_ChIP-Seq_HELA_Human0.78583629
129* GATA6_21074721_ChIP-Seq_CACO-2_Human0.77771968
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77709940
131HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77306058
132GATA6_25053715_ChIP-Seq_YYC3_Human0.77285509
133P68_20966046_ChIP-Seq_HELA_Human0.77118415
134BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76677501
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.76649131
136SA1_27219007_Chip-Seq_Bcells_Human0.76293396
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.74342079
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.73933070
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73496824
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73029097
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.71384986
142CLOCK_20551151_ChIP-Seq_293T_Human0.70879064
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.70793713
144GATA3_26560356_Chip-Seq_TH1_Human0.68836655
145SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.68698757
146SPI1_20517297_ChIP-Seq_HL60_Human0.68547899
147ELF1_20517297_ChIP-Seq_JURKAT_Human0.68423712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology8.10685796
2MP0004043_abnormal_pH_regulation6.44921825
3MP0002098_abnormal_vibrissa_morphology6.36141975
4MP0000383_abnormal_hair_follicle5.96274441
5MP0000647_abnormal_sebaceous_gland5.77490766
6MP0005275_abnormal_skin_tensile5.53271433
7MP0002796_impaired_skin_barrier5.41871142
8MP0010678_abnormal_skin_adnexa5.10088712
9MP0010234_abnormal_vibrissa_follicle4.17031151
10MP0000427_abnormal_hair_cycle4.12347653
11MP0000377_abnormal_hair_follicle3.95717090
12MP0002254_reproductive_system_inflammat3.35532902
13MP0005501_abnormal_skin_physiology3.25174971
14MP0003705_abnormal_hypodermis_morpholog2.83712513
15MP0001216_abnormal_epidermal_layer2.56053299
16MP0004947_skin_inflammation2.46570850
17MP0001661_extended_life_span2.24703728
18MP0010771_integument_phenotype2.22093056
19MP0001243_abnormal_dermal_layer2.18445805
20MP0000367_abnormal_coat/_hair2.13333487
21MP0004381_abnormal_hair_follicle2.11165246
22MP0003453_abnormal_keratinocyte_physiol2.04531711
23MP0000465_gastrointestinal_hemorrhage2.02814168
24MP0002060_abnormal_skin_morphology1.85928207
25MP0002095_abnormal_skin_pigmentation1.62391803
26MP0005409_darkened_coat_color1.54616698
27MP0000467_abnormal_esophagus_morphology1.54185365
28MP0009780_abnormal_chondrocyte_physiolo1.52653388
29MP0000762_abnormal_tongue_morphology1.40783672
30MP0002234_abnormal_pharynx_morphology1.40349277
31MP0009931_abnormal_skin_appearance1.39217608
32MP0003941_abnormal_skin_development1.36662163
33MP0003566_abnormal_cell_adhesion1.23870905
34MP0009053_abnormal_anal_canal1.21158434
35MP0005670_abnormal_white_adipose1.15152956
36MP0003878_abnormal_ear_physiology1.12699601
37MP0005377_hearing/vestibular/ear_phenot1.12699601
38MP0001346_abnormal_lacrimal_gland1.11197880
39MP0002009_preneoplasia1.07578956
40MP0000470_abnormal_stomach_morphology1.05566476
41MP0001765_abnormal_ion_homeostasis1.04716442
42MP0001191_abnormal_skin_condition1.00993059
43MP0004264_abnormal_extraembryonic_tissu0.97800654
44MP0000566_synostosis0.96580237
45MP0004885_abnormal_endolymph0.93647750
46MP0009333_abnormal_splenocyte_physiolog0.92825272
47MP0010368_abnormal_lymphatic_system0.87753815
48MP0004185_abnormal_adipocyte_glucose0.84561625
49MP0001340_abnormal_eyelid_morphology0.78679575
50MP0002877_abnormal_melanocyte_morpholog0.72954934
51MP0001851_eye_inflammation0.66031014
52MP0002075_abnormal_coat/hair_pigmentati0.64023313
53MP0005365_abnormal_bile_salt0.62288173
54MP0005636_abnormal_mineral_homeostasis0.60316817
55MP0001502_abnormal_circadian_rhythm0.60062778
56MP0000049_abnormal_middle_ear0.59418009
57MP0009384_cardiac_valve_regurgitation0.59283860
58MP0008438_abnormal_cutaneous_collagen0.56789275
59MP0002166_altered_tumor_susceptibility0.55815460
60MP0000372_irregular_coat_pigmentation0.55356005
61MP0000627_abnormal_mammary_gland0.54496759
62MP0010030_abnormal_orbit_morphology0.53424879
63MP0000003_abnormal_adipose_tissue0.52331570
64MP0002006_tumorigenesis0.50373530
65MP0001784_abnormal_fluid_regulation0.50324135
66MP0000681_abnormal_thyroid_gland0.49840622
67MP0003755_abnormal_palate_morphology0.47706267
68MP0002970_abnormal_white_adipose0.46043178
69MP0010352_gastrointestinal_tract_polyps0.45180152
70MP0004130_abnormal_muscle_cell0.44943299
71MP0001849_ear_inflammation0.43914586
72MP0009115_abnormal_fat_cell0.43296922
73MP0009643_abnormal_urine_homeostasis0.42694212
74MP0002697_abnormal_eye_size0.42517900
75MP0005248_abnormal_Harderian_gland0.42409628
76MP0009379_abnormal_foot_pigmentation0.40297804
77MP0002282_abnormal_trachea_morphology0.40275109
78MP0005166_decreased_susceptibility_to0.40206316
79MP0001270_distended_abdomen0.40196196
80MP0003724_increased_susceptibility_to0.40167168
81MP0001756_abnormal_urination0.40097351
82MP0002108_abnormal_muscle_morphology0.39998394
83MP0005023_abnormal_wound_healing0.39617869
84MP0002177_abnormal_outer_ear0.39500993
85MP0002136_abnormal_kidney_physiology0.36482072
86MP0003828_pulmonary_edema0.36077455
87MP0000432_abnormal_head_morphology0.35052650
88MP0001879_abnormal_lymphatic_vessel0.34948255
89MP0002138_abnormal_hepatobiliary_system0.34537798
90MP0000462_abnormal_digestive_system0.34133856
91MP0002111_abnormal_tail_morphology0.33984180
92MP0005171_absent_coat_pigmentation0.33823462
93MP0004272_abnormal_basement_membrane0.32891792
94MP0003315_abnormal_perineum_morphology0.32474151
95MP0003385_abnormal_body_wall0.32125380
96MP0003300_gastrointestinal_ulcer0.32025669
97MP0006138_congestive_heart_failure0.31136070
98MP0005075_abnormal_melanosome_morpholog0.30996021
99MP0001873_stomach_inflammation0.30025879
100MP0000920_abnormal_myelination0.30005695
101MP0000537_abnormal_urethra_morphology0.27650055
102MP0005257_abnormal_intraocular_pressure0.26594148
103MP0003890_abnormal_embryonic-extraembry0.26467053
104MP0005367_renal/urinary_system_phenotyp0.24816945
105MP0000516_abnormal_urinary_system0.24816945
106MP0003638_abnormal_response/metabolism_0.24651172
107MP0001485_abnormal_pinna_reflex0.24061549
108MP0000477_abnormal_intestine_morphology0.24000588
109MP0003950_abnormal_plasma_membrane0.23942767
110MP0005451_abnormal_body_composition0.23666085
111MP0003191_abnormal_cellular_cholesterol0.23309348
112MP0005076_abnormal_cell_differentiation0.22421265
113MP0000733_abnormal_muscle_development0.21976297
114MP0003935_abnormal_craniofacial_develop0.21953595
115MP0000631_abnormal_neuroendocrine_gland0.21604225
116MP0002249_abnormal_larynx_morphology0.21089105
117MP0005193_abnormal_anterior_eye0.19925551
118MP0001286_abnormal_eye_development0.18479051
119MP0006054_spinal_hemorrhage0.17558975
120MP0008961_abnormal_basal_metabolism0.17108176
121MP0005666_abnormal_adipose_tissue0.17092537
122MP0008875_abnormal_xenobiotic_pharmacok0.16900748
123MP0001958_emphysema0.16799547
124MP0001188_hyperpigmentation0.15885073
125MP0002653_abnormal_ependyma_morphology0.15700709
126MP0000613_abnormal_salivary_gland0.15637508
127MP0003937_abnormal_limbs/digits/tail_de0.15038902
128MP0010386_abnormal_urinary_bladder0.13477073
129MP0009703_decreased_birth_body0.13466357
130MP0001730_embryonic_growth_arrest0.12742051
131MP0001299_abnormal_eye_distance/0.11762864
132MP0000538_abnormal_urinary_bladder0.10529048
133MP0005408_hypopigmentation0.10474312
134MP0005375_adipose_tissue_phenotype0.10298360
135MP0005508_abnormal_skeleton_morphology0.09893533
136MP0002896_abnormal_bone_mineralization0.09852583
137MP0000678_abnormal_parathyroid_gland0.09352077
138MP0003763_abnormal_thymus_physiology0.08646197
139MP0005503_abnormal_tendon_morphology0.08496299
140MP0001186_pigmentation_phenotype0.07977454
141MP0000371_diluted_coat_color0.07366403
142MP0004197_abnormal_fetal_growth/weight/0.07036124
143MP0000428_abnormal_craniofacial_morphol0.06890916

Predicted human phenotypes

RankGene SetZ-score
1Slow-growing hair (HP:0002217)9.78011630
2Abnormality of hair growth rate (HP:0011363)9.78011630
3Pustule (HP:0200039)9.03925324
4Brittle hair (HP:0002299)8.81681911
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.68432424
6Follicular hyperkeratosis (HP:0007502)7.55112641
7Abnormal hair laboratory examination (HP:0003328)7.52260241
8Abnormality of nail color (HP:0100643)6.09032256
9Villous atrophy (HP:0011473)5.84616223
10Abnormality of small intestinal villus morphology (HP:0011472)5.84616223
11Nail dystrophy (HP:0008404)5.79649613
12Fragile nails (HP:0001808)5.51736090
13Congenital, generalized hypertrichosis (HP:0004540)5.34847342
14Hyperactive renin-angiotensin system (HP:0000841)5.28949803
15Palmoplantar hyperkeratosis (HP:0000972)4.77290568
16Fine hair (HP:0002213)4.73815156
17Alopecia of scalp (HP:0002293)4.68968520
18Sparse eyelashes (HP:0000653)4.66163707
19Nasal polyposis (HP:0100582)4.56658008
20Palmar hyperkeratosis (HP:0010765)4.51464705
21Erythema (HP:0010783)4.34835039
22Plantar hyperkeratosis (HP:0007556)4.30385966
23Hyperkalemia (HP:0002153)4.24349056
24Right ventricular cardiomyopathy (HP:0011663)4.20785714
25Onycholysis (HP:0001806)4.19077364
26Increased IgE level (HP:0003212)3.99533819
27Oral leukoplakia (HP:0002745)3.93225699
28Abnormality of the nasal mucosa (HP:0000433)3.87600698
29Thick nail (HP:0001805)3.75945720
30Abnormality of the salivary glands (HP:0010286)3.67504823
31Decreased circulating renin level (HP:0003351)3.62681591
32Parakeratosis (HP:0001036)3.54332800
33Dehydration (HP:0001944)3.48018005
34Chronic bronchitis (HP:0004469)3.46797438
35Abnormality of the frontal sinuses (HP:0002687)3.33625145
36Cystic hygroma (HP:0000476)3.25851194
37Amelogenesis imperfecta (HP:0000705)3.18465782
38Hypokalemic alkalosis (HP:0001949)2.98783117
39Neonatal hypoglycemia (HP:0001998)2.98091162
40Urticaria (HP:0001025)2.91430692
41Furrowed tongue (HP:0000221)2.90036121
42Milia (HP:0001056)2.85246014
43Eczematoid dermatitis (HP:0000976)2.76668038
44Abnormality of chloride homeostasis (HP:0011422)2.76201192
45Erythroderma (HP:0001019)2.69383627
46Hyperaldosteronism (HP:0000859)2.67677930
47Renal salt wasting (HP:0000127)2.66166184
48Curly hair (HP:0002212)2.66088303
49Intention tremor (HP:0002080)2.65480402
50Abnormality of renin-angiotensin system (HP:0000847)2.62690796
51Oligodontia (HP:0000677)2.61477398
52Aplasia cutis congenita (HP:0001057)2.59312248
53Distal lower limb muscle weakness (HP:0009053)2.45985938
54Delusions (HP:0000746)2.40298249
55Absence seizures (HP:0002121)2.38655678
56Hypergammaglobulinemia (HP:0010702)2.37960782
57Neck muscle weakness (HP:0000467)2.35895814
58Emphysema (HP:0002097)2.31535225
59Ridged nail (HP:0001807)2.30947494
60Advanced eruption of teeth (HP:0006288)2.28997260
61Natal tooth (HP:0000695)2.28384425
62Congenital ichthyosiform erythroderma (HP:0007431)2.27277627
63Absent eyelashes (HP:0000561)2.23349426
64Hoarse voice (HP:0001609)2.22777135
65Dry hair (HP:0011359)2.21566158
66Pruritus (HP:0000989)2.19782445
67Torticollis (HP:0000473)2.18865018
68Popliteal pterygium (HP:0009756)2.16882600
69Malnutrition (HP:0004395)2.13682279
70Verrucae (HP:0200043)2.13234186
71Papilloma (HP:0012740)2.13234186
72Abnormality of the parietal bone (HP:0002696)2.10855901
73Seborrheic dermatitis (HP:0001051)2.06568688
74Abnormal blistering of the skin (HP:0008066)2.05963662
75Concave nail (HP:0001598)2.05846554
76Hypotrichosis (HP:0001006)12.0148466
77Woolly hair (HP:0002224)11.9842255
78Pili torti (HP:0003777)11.8432217
79Corneal erosion (HP:0200020)1.98375641
80Thickened nuchal skin fold (HP:0000474)1.97475299
81Hypohidrosis (HP:0000966)1.95276234
82Palmoplantar keratoderma (HP:0000982)1.95106587
83Skin pits (HP:0100276)1.92283190
84Lip pit (HP:0100267)1.89779953
85Abnormality of the dental root (HP:0006486)1.88537825
86Taurodontia (HP:0000679)1.88537825
87Abnormality of permanent molar morphology (HP:0011071)1.88537825
88Ventricular tachycardia (HP:0004756)1.88526164
89Rectal prolapse (HP:0002035)1.86293673
90Melanocytic nevus (HP:0000995)1.84253659
91Abnormality of molar morphology (HP:0011070)1.83394417
92Abnormality of molar (HP:0011077)1.83394417
93Hyponatremia (HP:0002902)1.79682268
94Widely patent fontanelles and sutures (HP:0004492)1.79542008
95Craniofacial dystonia (HP:0012179)1.79455284
96Coarse hair (HP:0002208)1.78669861
97Acne (HP:0001061)1.78267601
98Difficulty walking (HP:0002355)1.78128858
99Low posterior hairline (HP:0002162)1.75095002
100Amniotic constriction ring (HP:0009775)1.75009073
101Abnormality of placental membranes (HP:0011409)1.75009073
102Labial hypoplasia (HP:0000066)1.74422365
103Ventricular fibrillation (HP:0001663)1.71550572
104Abnormality of dental color (HP:0011073)1.71368235
105Conjunctival hamartoma (HP:0100780)1.69328671
106Recurrent corneal erosions (HP:0000495)1.68912441
107Blepharitis (HP:0000498)1.68483656
108Abnormality of potassium homeostasis (HP:0011042)1.66072345
109Dialeptic seizures (HP:0011146)1.65036257
110Abnormality of the dental pulp (HP:0006479)1.63920495
111Abnormality of the pupil (HP:0000615)1.63187890
112Focal dystonia (HP:0004373)1.62595973
113Hyporeflexia of lower limbs (HP:0002600)1.61010498
114Hypoplastic labia majora (HP:0000059)1.58884284
115Adrenal overactivity (HP:0002717)1.58772332
116Hypoplastic female external genitalia (HP:0012815)1.57954836
117Craniofacial hyperostosis (HP:0004493)1.57631182
118Papillary thyroid carcinoma (HP:0002895)1.54994607
119Lymphedema (HP:0001004)1.52524088
120Dry skin (HP:0000958)1.52171199
121Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.51933925
122Sparse scalp hair (HP:0002209)1.50836275
123Acanthosis nigricans (HP:0000956)1.49925275
124Obstructive sleep apnea (HP:0002870)1.49234889
125Webbed neck (HP:0000465)1.49009270
126Widely spaced teeth (HP:0000687)1.48389828
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.46611477
128Asthma (HP:0002099)1.43065341
129Skin rash (HP:0000988)1.42902252
130Autoamputation (HP:0001218)1.41741180
131Hematochezia (HP:0002573)1.41443601
132Carious teeth (HP:0000670)1.40904670
133Abnormality of the labia majora (HP:0012881)1.39758077
134Abnormality of sodium homeostasis (HP:0010931)1.39642675
135Keratoconjunctivitis sicca (HP:0001097)1.37950479
136Abnormality of the aortic arch (HP:0012303)1.36599002
137Split foot (HP:0001839)1.36244708
138Unilateral renal agenesis (HP:0000122)1.36217239
139Keratoconjunctivitis (HP:0001096)1.36066183
140Ectropion (HP:0000656)1.32948413
141Gangrene (HP:0100758)1.30288678
142Anonychia (HP:0001798)1.27813261
143Abnormality of the fingernails (HP:0001231)1.27166577
144Fatigable weakness (HP:0003473)1.22620460
145Abnormality of the neuromuscular junction (HP:0003398)1.22620460
146Abnormality of the gastric mucosa (HP:0004295)1.19609864
147Selective tooth agenesis (HP:0001592)1.17349718
148Cranial hyperostosis (HP:0004437)1.17347242
149Type 1 muscle fiber predominance (HP:0003803)1.15951092
150Absent hair (HP:0002298)1.15830821
151Neonatal death (HP:0003811)1.13970836
152Atrophic scars (HP:0001075)1.12394418
153Sudden death (HP:0001699)1.12038966
154Round ear (HP:0100830)1.11201719
155Abnormality of the axillary hair (HP:0100134)1.10574047
156Abnormality of secondary sexual hair (HP:0009888)1.10574047
157Wide cranial sutures (HP:0010537)1.09006945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.17164486
2FER3.75470969
3FGFR23.59353904
4EPHA23.57577091
5MAP3K63.20914442
6EPHB23.03606172
7MAP3K22.85501031
8CAMK1D2.82528977
9WNK12.75011315
10MAP3K32.64430405
11MAPKAPK32.63305702
12WNK42.62951398
13TAOK12.60428778
14ERN12.59206123
15FGFR32.46657340
16STK392.37566237
17TTN2.30335567
18BCR2.26383426
19FGFR12.23548841
20CAMK1G2.22547099
21FRK2.10597714
22PIK3CG1.95473263
23MARK21.91047090
24TRIB31.88678751
25AKT31.73595875
26CDK61.65334863
27MAP3K111.62295903
28RPS6KB21.61868047
29SGK4941.60144914
30SGK2231.60144914
31LATS21.55102045
32PTK61.38212720
33EPHB11.36948096
34PDGFRA1.36462243
35MAP3K71.25947026
36MST1R1.20174935
37STK31.16563648
38EEF2K1.10700192
39ERBB31.09483254
40TRPM71.08535701
41ERBB41.08251319
42NEK11.04261494
43DYRK1B1.02267703
44MAP3K10.98783939
45MAP2K60.98352579
46GRK60.97875207
47SCYL20.94926064
48PBK0.94541316
49KSR20.93997873
50CSK0.93409744
51IRAK10.90431257
52MAPKAPK20.87391874
53RIPK10.87123674
54MAP2K30.84696357
55PRKAA20.82288100
56MAP3K90.81994997
57SIK10.81378432
58AKT20.79143563
59RPS6KA40.78960557
60FGFR40.77779714
61MAP3K120.76444204
62NME10.76400824
63MET0.76138188
64PTK20.76077005
65PKN20.73734817
66BMX0.73127470
67PIK3CA0.72151664
68ERBB20.72074451
69STK38L0.71564489
70LRRK20.71494744
71MAP2K40.70956610
72PRKD20.70680940
73MST40.68446143
74FGR0.68321365
75IRAK20.66071683
76OBSCN0.63317893
77MAP3K100.62198439
78ICK0.61659710
79IKBKE0.60078417
80RPS6KB10.60059912
81IRAK40.57604872
82DMPK0.56241588
83MAP3K50.55332781
84SGK30.55307288
85CDK120.54544404
86DAPK20.54164525
87TGFBR10.54096066
88CSNK1G10.52447438
89NEK20.51563599
90HIPK20.50998495
91MAP2K10.50356220
92MYLK0.49742443
93PRKD10.49231933
94STK380.49093530
95CHUK0.49023947
96CSNK1E0.48522246
97STK240.48439524
98PAK30.47299907
99CSNK1A1L0.46912432
100CDK90.44071321
101SIK30.42019109
102GSK3A0.41864515
103RPS6KA20.41104634
104PAK40.40833540
105TYRO30.38465186
106MTOR0.38359589
107DDR20.38008691
108TESK10.36584615
109PDGFRB0.36434189
110CAMK40.35833716
111ZAP700.35535754
112KSR10.35052830
113PRKCH0.34952587
114RPS6KA10.34339399
115RET0.34324983
116MARK30.33171266
117TBK10.32696938
118SGK20.32322194
119PAK20.31964072
120SGK10.29820299
121LIMK10.29674581
122PDPK10.29629250
123EPHA30.28633454
124CSNK1D0.28396652
125JAK10.28384223
126EGFR0.28144486
127NTRK20.28092770
128FYN0.26686255
129STK110.26591775
130MAPK70.26165063
131AURKB0.26061507
132CDC42BPA0.25919028
133PRKD30.24821771
134MAPK10.24359902
135AKT10.24334740
136PINK10.24299262
137TGFBR20.24242752
138JAK20.24189513
139STK40.23954719
140CSNK1G30.23857815
141MAP3K40.23809638
142ITK0.22848778
143ATM0.22654388
144CAMK10.21996397
145MAPK30.21126631
146PRKDC0.19190693
147ROCK10.18714363
148MAPKAPK50.16354832
149MELK0.16159207

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047103.93902876
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.65026548
3Linoleic acid metabolism_Homo sapiens_hsa005913.41221766
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.40875663
5Basal cell carcinoma_Homo sapiens_hsa052172.83966857
6Fat digestion and absorption_Homo sapiens_hsa049752.48965091
7Fatty acid elongation_Homo sapiens_hsa000622.41575874
8Phenylalanine metabolism_Homo sapiens_hsa003602.30333881
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.07633737
10Notch signaling pathway_Homo sapiens_hsa043302.03218253
11Hippo signaling pathway_Homo sapiens_hsa043901.97782497
12Melanogenesis_Homo sapiens_hsa049161.88745944
13Ether lipid metabolism_Homo sapiens_hsa005651.85875083
14Hedgehog signaling pathway_Homo sapiens_hsa043401.77566740
15Sulfur metabolism_Homo sapiens_hsa009201.76739105
16Thyroid cancer_Homo sapiens_hsa052161.72509220
17Histidine metabolism_Homo sapiens_hsa003401.71609060
18Adherens junction_Homo sapiens_hsa045201.66086687
19Bladder cancer_Homo sapiens_hsa052191.65126625
20Dorso-ventral axis formation_Homo sapiens_hsa043201.64724642
21Glioma_Homo sapiens_hsa052141.63955993
22Tyrosine metabolism_Homo sapiens_hsa003501.60160383
23Proteoglycans in cancer_Homo sapiens_hsa052051.58959350
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58956846
25Mineral absorption_Homo sapiens_hsa049781.56782697
26Axon guidance_Homo sapiens_hsa043601.52482650
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48155781
28TGF-beta signaling pathway_Homo sapiens_hsa043501.43513591
29VEGF signaling pathway_Homo sapiens_hsa043701.42183235
30Tight junction_Homo sapiens_hsa045301.41968896
31Endometrial cancer_Homo sapiens_hsa052131.38731047
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.37873565
33Endocytosis_Homo sapiens_hsa041441.30781258
34Long-term potentiation_Homo sapiens_hsa047201.30059701
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.28533330
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23585150
37Glutathione metabolism_Homo sapiens_hsa004801.21499997
38Arachidonic acid metabolism_Homo sapiens_hsa005901.19116575
39Nitrogen metabolism_Homo sapiens_hsa009101.18469097
40Collecting duct acid secretion_Homo sapiens_hsa049661.18157417
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17625173
42Wnt signaling pathway_Homo sapiens_hsa043101.14534164
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.11368472
44Non-small cell lung cancer_Homo sapiens_hsa052231.10997082
45Acute myeloid leukemia_Homo sapiens_hsa052211.09128385
46MicroRNAs in cancer_Homo sapiens_hsa052061.08958081
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07267886
48ECM-receptor interaction_Homo sapiens_hsa045121.05878168
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.04331272
50GnRH signaling pathway_Homo sapiens_hsa049121.03115476
51Steroid biosynthesis_Homo sapiens_hsa001001.00128036
52Vibrio cholerae infection_Homo sapiens_hsa051100.97511167
53Serotonergic synapse_Homo sapiens_hsa047260.95998788
54Salmonella infection_Homo sapiens_hsa051320.95586607
55PPAR signaling pathway_Homo sapiens_hsa033200.95108129
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93801927
57Caffeine metabolism_Homo sapiens_hsa002320.90772353
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87690128
59Inositol phosphate metabolism_Homo sapiens_hsa005620.85919895
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85162836
61Insulin resistance_Homo sapiens_hsa049310.83229039
62Long-term depression_Homo sapiens_hsa047300.82716246
63Lysine degradation_Homo sapiens_hsa003100.82327978
64Retinol metabolism_Homo sapiens_hsa008300.81815152
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81519527
66Focal adhesion_Homo sapiens_hsa045100.81371093
67beta-Alanine metabolism_Homo sapiens_hsa004100.80551417
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80452109
69Influenza A_Homo sapiens_hsa051640.78535846
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.78316062
71p53 signaling pathway_Homo sapiens_hsa041150.77413357
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75002097
73Amoebiasis_Homo sapiens_hsa051460.74807503
74Melanoma_Homo sapiens_hsa052180.73521263
75Ras signaling pathway_Homo sapiens_hsa040140.73125789
76Hepatitis C_Homo sapiens_hsa051600.71617036
77Estrogen signaling pathway_Homo sapiens_hsa049150.71484782
78Pertussis_Homo sapiens_hsa051330.71363940
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70367531
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70062168
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69790854
82Glucagon signaling pathway_Homo sapiens_hsa049220.69758903
83FoxO signaling pathway_Homo sapiens_hsa040680.69646784
84Shigellosis_Homo sapiens_hsa051310.68803937
85Choline metabolism in cancer_Homo sapiens_hsa052310.68569832
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.67531609
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66878200
88Synaptic vesicle cycle_Homo sapiens_hsa047210.66620379
89Salivary secretion_Homo sapiens_hsa049700.65328242
90Chemical carcinogenesis_Homo sapiens_hsa052040.65292973
91Pancreatic secretion_Homo sapiens_hsa049720.65235736
92Rap1 signaling pathway_Homo sapiens_hsa040150.65126773
93Prostate cancer_Homo sapiens_hsa052150.64853306
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63302230
95Renal cell carcinoma_Homo sapiens_hsa052110.63269729
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.61910500
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.61642443
98Prolactin signaling pathway_Homo sapiens_hsa049170.61619114
99ErbB signaling pathway_Homo sapiens_hsa040120.60614690
100TNF signaling pathway_Homo sapiens_hsa046680.59008708
101Chronic myeloid leukemia_Homo sapiens_hsa052200.57975894
102Renin secretion_Homo sapiens_hsa049240.55601108
103Tuberculosis_Homo sapiens_hsa051520.55557470
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55264873
105mTOR signaling pathway_Homo sapiens_hsa041500.54956390
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54065467
107Pancreatic cancer_Homo sapiens_hsa052120.53648520
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52768596
109Pathways in cancer_Homo sapiens_hsa052000.52686169
110AMPK signaling pathway_Homo sapiens_hsa041520.51959523
111Platelet activation_Homo sapiens_hsa046110.51374919
112Fatty acid metabolism_Homo sapiens_hsa012120.49815252
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49451090
114Gastric acid secretion_Homo sapiens_hsa049710.48860758
115Insulin signaling pathway_Homo sapiens_hsa049100.48672928
116Butanoate metabolism_Homo sapiens_hsa006500.47747161
117Oxytocin signaling pathway_Homo sapiens_hsa049210.47551467
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47292893
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46965094
120Gap junction_Homo sapiens_hsa045400.45414396
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45216469
122Protein digestion and absorption_Homo sapiens_hsa049740.43931425
123Phototransduction_Homo sapiens_hsa047440.43682244
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.41659736
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41106060
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40942863
127Fatty acid degradation_Homo sapiens_hsa000710.40677641
128Chemokine signaling pathway_Homo sapiens_hsa040620.40118252
129Taste transduction_Homo sapiens_hsa047420.39571875
130Arginine biosynthesis_Homo sapiens_hsa002200.39238679
131T cell receptor signaling pathway_Homo sapiens_hsa046600.39100677
132HTLV-I infection_Homo sapiens_hsa051660.38800323
133Toxoplasmosis_Homo sapiens_hsa051450.38459165
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37517251
135Small cell lung cancer_Homo sapiens_hsa052220.37018493
136Starch and sucrose metabolism_Homo sapiens_hsa005000.36274490
137MAPK signaling pathway_Homo sapiens_hsa040100.36130133
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35915909
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35545313
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.35411141

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