ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of granulocyte differentiation (GO:0030854)	4.77629364
2	positive regulation of gamma-delta T cell activation (GO:0046645)	4.59755388
3	regulation of gamma-delta T cell differentiation (GO:0045586)	4.47359130
4	activated T cell proliferation (GO:0050798)	4.45199428
5	negative T cell selection (GO:0043383)	4.30668517
6	positive thymic T cell selection (GO:0045059)	4.26188020
7	negative thymic T cell selection (GO:0045060)	4.08187190
8	positive T cell selection (GO:0043368)	4.07435009
9	response to interleukin-15 (GO:0070672)	3.98632280
10	cellular response to interleukin-15 (GO:0071350)	3.91425182
11	regulation of gamma-delta T cell activation (GO:0046643)	3.85799313
12	thymic T cell selection (GO:0045061)	3.67748759
13	DNA deamination (GO:0045006)	3.66066339
14	regulation of B cell receptor signaling pathway (GO:0050855)	3.55275067
15	S-adenosylmethionine metabolic process (GO:0046500)	3.52831869
16	mast cell activation involved in immune response (GO:0002279)	3.44204894
17	mast cell degranulation (GO:0043303)	3.44204894
18	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.39145714
19	disruption of cells of other organism (GO:0044364)	3.36261296
20	killing of cells of other organism (GO:0031640)	3.36261296
21	positive regulation of B cell differentiation (GO:0045579)	3.32573081
22	T cell selection (GO:0045058)	3.31319413
23	sulfation (GO:0051923)	3.27445955
24	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.20580517
25	negative regulation of cell killing (GO:0031342)	3.20580517
26	regulation of granulocyte differentiation (GO:0030852)	3.20157375
27	Peyers patch development (GO:0048541)	3.18303255
28	mucosal-associated lymphoid tissue development (GO:0048537)	3.18303255
29	oxygen transport (GO:0015671)	3.17395528
30	regulation of B cell differentiation (GO:0045577)	3.15898398
31	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.10609742
32	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.09873275
33	regulation of activation of Janus kinase activity (GO:0010533)	3.07058358
34	gamma-aminobutyric acid transport (GO:0015812)	3.03678583
35	cytidine catabolic process (GO:0006216)	3.02943985
36	cytidine deamination (GO:0009972)	3.02943985
37	cytidine metabolic process (GO:0046087)	3.02943985
38	imidazole-containing compound metabolic process (GO:0052803)	3.02341191
39	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.99145895
40	mast cell activation (GO:0045576)	2.87313709
41	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.85207546
42	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.85137676
43	histone H3-K9 modification (GO:0061647)	2.83707275
44	mannose metabolic process (GO:0006013)	2.83540486
45	negative regulation of T cell mediated immunity (GO:0002710)	2.82066743
46	serine family amino acid catabolic process (GO:0009071)	2.80235385
47	B cell receptor signaling pathway (GO:0050853)	2.77921734
48	fucose catabolic process (GO:0019317)	2.77312293
49	L-fucose metabolic process (GO:0042354)	2.77312293
50	L-fucose catabolic process (GO:0042355)	2.77312293
51	interferon-gamma production (GO:0032609)	2.75682791
52	exogenous drug catabolic process (GO:0042738)	2.75269112
53	behavioral response to nicotine (GO:0035095)	2.75118985
54	negative regulation of lymphocyte mediated immunity (GO:0002707)	2.74782244
55	histone H3-K9 methylation (GO:0051567)	2.74416149
56	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.73059975
57	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.72958403
58	protoporphyrinogen IX metabolic process (GO:0046501)	2.70127544
59	regulation of triglyceride catabolic process (GO:0010896)	2.68189293
60	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.68103009
61	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.68103009
62	autophagic vacuole fusion (GO:0000046)	2.67223750
63	negative regulation of cAMP-mediated signaling (GO:0043951)	2.66679279
64	regulation of natural killer cell differentiation (GO:0032823)	2.65396117
65	positive regulation of defense response to virus by host (GO:0002230)	2.63137593
66	negative regulation of adaptive immune response based on somatic recombination of immune receptors b	2.61220987
67	defense response to fungus (GO:0050832)	2.60630093
68	drug catabolic process (GO:0042737)	2.59729735
69	positive regulation of protein homodimerization activity (GO:0090073)	2.58785576
70	short-chain fatty acid metabolic process (GO:0046459)	2.57334905
71	positive regulation of T cell differentiation in thymus (GO:0033089)	2.56205705
72	adaptation of signaling pathway (GO:0023058)	2.54217946
73	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.54041091
74	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.53279737
75	negative regulation of adaptive immune response (GO:0002820)	2.52785234
76	cellular extravasation (GO:0045123)	2.52779697
77	iron-sulfur cluster assembly (GO:0016226)	2.52179725
78	metallo-sulfur cluster assembly (GO:0031163)	2.52179725
79	T cell migration (GO:0072678)	2.51958861
80	potassium ion export (GO:0071435)	2.50760885
81	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.50240024
82	negative regulation of telomere maintenance (GO:0032205)	2.49456146
83	gas transport (GO:0015669)	2.47391175
84	detection of bacterium (GO:0016045)	2.46522744
85	positive regulation of CREB transcription factor activity (GO:0032793)	2.45652147
86	regulation of memory T cell differentiation (GO:0043380)	2.45626761
87	positive regulation by host of viral transcription (GO:0043923)	2.44228749
88	omega-hydroxylase P450 pathway (GO:0097267)	2.43851062
89	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.43298509
90	rRNA catabolic process (GO:0016075)	2.43108663
91	positive regulation of T cell cytokine production (GO:0002726)	2.41953914
92	histone H2A acetylation (GO:0043968)	2.38624235
93	regulation of T cell mediated cytotoxicity (GO:0001914)	2.38562913
94	regulation of T cell cytokine production (GO:0002724)	2.37672101
95	indole-containing compound catabolic process (GO:0042436)	2.37221616
96	indolalkylamine catabolic process (GO:0046218)	2.37221616
97	tryptophan catabolic process (GO:0006569)	2.37221616
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.35416751
99	regulation of lipoprotein particle clearance (GO:0010984)	2.35155379
100	actin nucleation (GO:0045010)	2.34395300

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.41691156
2	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.71617231
3	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.69838443
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.62584185
5	CIITA_25753668_ChIP-Seq_RAJI_Human	2.47742521
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.43169373
7	GATA1_22025678_ChIP-Seq_K562_Human	2.42777463
8	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.27293912
9	MYC_22102868_ChIP-Seq_BL_Human	2.25353392
10	VDR_21846776_ChIP-Seq_THP-1_Human	2.16927178
11	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.10201598
12	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.10137252
13	SCL_19346495_ChIP-Seq_HPC-7_Human	2.06119269
14	MAF_26560356_Chip-Seq_TH2_Human	2.05493983
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.01632773
16	UTX_26944678_Chip-Seq_JUKART_Human	1.97310345
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.96929610
18	BCL6_27268052_Chip-Seq_Bcells_Human	1.94536081
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92937544
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92864904
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.84884428
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.81202476
23	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.79234265
24	MAF_26560356_Chip-Seq_TH1_Human	1.75597226
25	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.75468919
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73816121
27	P68_20966046_ChIP-Seq_HELA_Human	1.73710335
28	MYB_26560356_Chip-Seq_TH2_Human	1.72923467
29	RUNX_20019798_ChIP-Seq_JUKART_Human	1.72515110
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.70928314
31	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.66627138
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64527765
33	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.62637922
34	PHF8_20622854_ChIP-Seq_HELA_Human	1.62226003
35	E2F1_20622854_ChIP-Seq_HELA_Human	1.62093552
36	BCOR_27268052_Chip-Seq_Bcells_Human	1.61704089
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58350804
38	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.57152020
39	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.55491160
40	MYB_26560356_Chip-Seq_TH1_Human	1.53302265
41	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.51655732
42	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.50362308
43	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.49336281
44	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.48779886
45	ERA_21632823_ChIP-Seq_H3396_Human	1.48553506
46	RAC3_21632823_ChIP-Seq_H3396_Human	1.45160663
47	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.43727458
48	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.42947444
49	KDM5A_27292631_Chip-Seq_BREAST_Human	1.38523248
50	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.36916724
51	GATA3_27048872_Chip-Seq_THYMUS_Human	1.36364899
52	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.31908275
53	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.30440630
54	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.30291161
55	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27609658
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27496952
57	P300_27268052_Chip-Seq_Bcells_Human	1.26399888
58	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.25573076
59	OCT4_20526341_ChIP-Seq_ESCs_Human	1.24439821
60	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.24185140
61	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.23574513
62	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.23440662
63	GATA1_19941826_ChIP-Seq_K562_Human	1.23017461
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.21840094
65	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.21795889
66	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21676422
67	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21387875
68	KDM2B_26808549_Chip-Seq_DND41_Human	1.21016187
69	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.20184028
70	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.19839589
71	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.19715862
72	GATA3_26560356_Chip-Seq_TH2_Human	1.19714013
73	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.19197798
74	DROSHA_22980978_ChIP-Seq_HELA_Human	1.18819128
75	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.18115629
76	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.17043729
77	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.16951127
78	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.16903094
79	SPI1_20517297_ChIP-Seq_HL60_Human	1.16016280
80	SMC4_20622854_ChIP-Seq_HELA_Human	1.15542376
81	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.14707456
82	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13845321
83	MYC_18940864_ChIP-ChIP_HL60_Human	1.13358429
84	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.11830526
85	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11309268
86	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.10808803
87	SPI1_23547873_ChIP-Seq_NB4_Human	1.09960396
88	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09883658
89	OCT4_19829295_ChIP-Seq_ESCs_Human	1.09595254
90	LXR_22292898_ChIP-Seq_THP-1_Human	1.09307101
91	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.08870226
92	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.08843390
93	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.07390164
94	SA1_27219007_Chip-Seq_Bcells_Human	1.07127296
95	CTCF_20526341_ChIP-Seq_ESCs_Human	1.06263834
96	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.05645271
97	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.05184591
98	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.03301756
99	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03188453
100	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.02800787

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.86000245
2	MP0003763_abnormal_thymus_physiology	3.28644204
3	MP0004147_increased_porphyrin_level	3.12434690
4	MP0005671_abnormal_response_to	2.77729439
5	MP0005360_urolithiasis	2.41726059
6	MP0008995_early_reproductive_senescence	2.27594664
7	MP0003656_abnormal_erythrocyte_physiolo	2.13320820
8	MP0001800_abnormal_humoral_immune	2.04598936
9	MP0001986_abnormal_taste_sensitivity	1.77457551
10	MP0000703_abnormal_thymus_morphology	1.75705110
11	MP0009278_abnormal_bone_marrow	1.75143288
12	MP0002398_abnormal_bone_marrow	1.74177332
13	MP0000685_abnormal_immune_system	1.71756672
14	MP0002653_abnormal_ependyma_morphology	1.68259540
15	MP0001835_abnormal_antigen_presentation	1.68020760
16	MP0003195_calcinosis	1.65522411
17	MP0002249_abnormal_larynx_morphology	1.64979129
18	MP0003436_decreased_susceptibility_to	1.63868371
19	MP0002420_abnormal_adaptive_immunity	1.63650888
20	MP0002723_abnormal_immune_serum	1.63383559
21	MP0001873_stomach_inflammation	1.63042064
22	MP0001819_abnormal_immune_cell	1.62267945
23	MP0005451_abnormal_body_composition	1.59529139
24	MP0002722_abnormal_immune_system	1.57623404
25	MP0009333_abnormal_splenocyte_physiolog	1.57117068
26	MP0005025_abnormal_response_to	1.56905856
27	MP0001764_abnormal_homeostasis	1.56599140
28	MP0000689_abnormal_spleen_morphology	1.55368392
29	MP0002138_abnormal_hepatobiliary_system	1.53022140
30	MP0005000_abnormal_immune_tolerance	1.52489537
31	MP0002132_abnormal_respiratory_system	1.50750997
32	MP0005397_hematopoietic_system_phenotyp	1.50166855
33	MP0001545_abnormal_hematopoietic_system	1.50166855
34	MP0008875_abnormal_xenobiotic_pharmacok	1.49618915
35	MP0009785_altered_susceptibility_to	1.47506887
36	MP0000716_abnormal_immune_system	1.45647986
37	MP0001790_abnormal_immune_system	1.42394852
38	MP0005387_immune_system_phenotype	1.42394852
39	MP0002405_respiratory_system_inflammati	1.40334239
40	MP0001529_abnormal_vocalization	1.39225851
41	MP0006035_abnormal_mitochondrial_morpho	1.38630749
42	MP0002452_abnormal_antigen_presenting	1.33715236
43	MP0001270_distended_abdomen	1.32384157
44	MP0005085_abnormal_gallbladder_physiolo	1.29570731
45	MP0004142_abnormal_muscle_tone	1.27908620
46	MP0002822_catalepsy	1.27562844
47	MP0005075_abnormal_melanosome_morpholog	1.27426240
48	MP0002429_abnormal_blood_cell	1.21749220
49	MP0003172_abnormal_lysosome_physiology	1.20461006
50	MP0001968_abnormal_touch/_nociception	1.18663681
51	MP0010329_abnormal_lipoprotein_level	1.16364230
52	MP0003786_premature_aging	1.15331424
53	MP0005365_abnormal_bile_salt	1.15295235
54	MP0005377_hearing/vestibular/ear_phenot	1.15263907
55	MP0003878_abnormal_ear_physiology	1.15263907
56	MP0008872_abnormal_physiological_respon	1.14899225
57	MP0003866_abnormal_defecation	1.13134395
58	MP0004381_abnormal_hair_follicle	1.10981456
59	MP0005174_abnormal_tail_pigmentation	1.10104424
60	MP0002139_abnormal_hepatobiliary_system	1.09037032
61	MP0002419_abnormal_innate_immunity	1.08830570
62	MP0003252_abnormal_bile_duct	1.05192980
63	MP0006036_abnormal_mitochondrial_physio	1.04819605
64	MP0002396_abnormal_hematopoietic_system	0.94050558
65	MP0001984_abnormal_olfaction	0.93154980
66	MP0002933_joint_inflammation	0.92795228
67	MP0002102_abnormal_ear_morphology	0.91698822
68	MP0005083_abnormal_biliary_tract	0.91232692
69	MP0001845_abnormal_inflammatory_respons	0.86213143
70	MP0005645_abnormal_hypothalamus_physiol	0.85826457
71	MP0008058_abnormal_DNA_repair	0.85086390
72	MP0005551_abnormal_eye_electrophysiolog	0.83657064
73	MP0001501_abnormal_sleep_pattern	0.83156398
74	MP0003303_peritoneal_inflammation	0.82193284
75	MP0010155_abnormal_intestine_physiology	0.76937895
76	MP0008961_abnormal_basal_metabolism	0.75615102
77	MP0002009_preneoplasia	0.75497629
78	MP0005220_abnormal_exocrine_pancreas	0.75383113
79	MP0000609_abnormal_liver_physiology	0.73782893
80	MP0008469_abnormal_protein_level	0.73305236
81	MP0005636_abnormal_mineral_homeostasis	0.73245130
82	MP0001486_abnormal_startle_reflex	0.72735221
83	MP0005646_abnormal_pituitary_gland	0.72039766
84	MP0003646_muscle_fatigue	0.71212630
85	MP0003698_abnormal_male_reproductive	0.70829834
86	MP0006072_abnormal_retinal_apoptosis	0.70369180
87	MP0002928_abnormal_bile_duct	0.70246809
88	MP0005253_abnormal_eye_physiology	0.69303000
89	MP0002277_abnormal_respiratory_mucosa	0.69032503
90	MP0005448_abnormal_energy_balance	0.68393504
91	MP0004130_abnormal_muscle_cell	0.67974400
92	MP0009764_decreased_sensitivity_to	0.67965760
93	MP0003724_increased_susceptibility_to	0.67416049
94	MP0000015_abnormal_ear_pigmentation	0.67265544
95	MP0006292_abnormal_olfactory_placode	0.67097307
96	MP0002019_abnormal_tumor_incidence	0.64943480
97	MP0004742_abnormal_vestibular_system	0.64143009
98	MP0005171_absent_coat_pigmentation	0.63651059
99	MP0001663_abnormal_digestive_system	0.63233376
100	MP0000631_abnormal_neuroendocrine_gland	0.62498422

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.41303509
2	Hypochromic microcytic anemia (HP:0004840)	3.69478781
3	Panhypogammaglobulinemia (HP:0003139)	3.62597915
4	Optic neuritis (HP:0100653)	3.46369236
5	Retrobulbar optic neuritis (HP:0100654)	3.46369236
6	Myositis (HP:0100614)	3.40624387
7	Severe combined immunodeficiency (HP:0004430)	3.33080696
8	Pustule (HP:0200039)	3.25746874
9	Poikilocytosis (HP:0004447)	3.07248338
10	Hypochromic anemia (HP:0001931)	2.99258204
11	Orchitis (HP:0100796)	2.96118982
12	Abnormality of DNA repair (HP:0003254)	2.79633839
13	Recurrent fungal infections (HP:0002841)	2.76397117
14	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.71084838
15	Granulocytopenia (HP:0001913)	2.70940903
16	Abnormality of eosinophils (HP:0001879)	2.67307001
17	IgG deficiency (HP:0004315)	2.65517468
18	Stomatitis (HP:0010280)	2.64618709
19	Pancreatic cysts (HP:0001737)	2.64390008
20	Reticulocytosis (HP:0001923)	2.63217200
21	Congenital stationary night blindness (HP:0007642)	2.61710000
22	Cerebral palsy (HP:0100021)	2.51551608
23	Meningitis (HP:0001287)	2.47777938
24	Keratoconjunctivitis (HP:0001096)	2.39663753
25	Abnormal number of erythroid precursors (HP:0012131)	2.36720313
26	Abnormal biliary tract physiology (HP:0012439)	2.35819339
27	Bile duct proliferation (HP:0001408)	2.35819339
28	Retinal dysplasia (HP:0007973)	2.35797787
29	Type II lissencephaly (HP:0007260)	2.34711772
30	T lymphocytopenia (HP:0005403)	2.33367327
31	Keratoconjunctivitis sicca (HP:0001097)	2.33004361
32	Eosinophilia (HP:0001880)	2.30954116
33	Obstructive lung disease (HP:0006536)	2.28472572
34	Chronic obstructive pulmonary disease (HP:0006510)	2.28472572
35	Thyroiditis (HP:0100646)	2.25882096
36	Keratitis (HP:0000491)	2.24265126
37	Encephalitis (HP:0002383)	2.23939018
38	Abnormality of T cells (HP:0002843)	2.23799103
39	Large for gestational age (HP:0001520)	2.22624323
40	Combined immunodeficiency (HP:0005387)	2.20325605
41	Recurrent cutaneous fungal infections (HP:0011370)	2.17693970
42	Chronic mucocutaneous candidiasis (HP:0002728)	2.17693970
43	Agammaglobulinemia (HP:0004432)	2.17101907
44	Progressive cerebellar ataxia (HP:0002073)	2.15618098
45	Abnormality of transition element cation homeostasis (HP:0011030)	2.13941536
46	Pancreatic fibrosis (HP:0100732)	2.12143807
47	Abnormality of T cell number (HP:0011839)	2.10958373
48	Methylmalonic acidemia (HP:0002912)	2.10687249
49	Hemoptysis (HP:0002105)	2.08997780
50	Prolonged bleeding time (HP:0003010)	2.08991644
51	Microcytic anemia (HP:0001935)	2.06734536
52	Abnormality of reticulocytes (HP:0004312)	2.03745448
53	Gastrointestinal infarctions (HP:0005244)	2.02446343
54	Ketosis (HP:0001946)	2.02264675
55	Supernumerary bones of the axial skeleton (HP:0009144)	2.00402607
56	Pendular nystagmus (HP:0012043)	1.99400732
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.98870650
58	Abnormality of the pleura (HP:0002103)	1.97909856
59	True hermaphroditism (HP:0010459)	1.97526313
60	Pulmonary infiltrates (HP:0002113)	1.96860271
61	Pulmonary embolism (HP:0002204)	1.95589079
62	Methylmalonic aciduria (HP:0012120)	1.95516733
63	Nephronophthisis (HP:0000090)	1.94713625
64	Elevated erythrocyte sedimentation rate (HP:0003565)	1.94403782
65	Cystic liver disease (HP:0006706)	1.93065877
66	Seborrheic dermatitis (HP:0001051)	1.91617588
67	Patellar aplasia (HP:0006443)	1.90999561
68	Abnormality of the columella (HP:0009929)	1.89884997
69	Abnormality of B cell number (HP:0010975)	1.89486102
70	Leukocytosis (HP:0001974)	1.89081486
71	Abnormality of iron homeostasis (HP:0011031)	1.88524036
72	Hyperglycinemia (HP:0002154)	1.87615848
73	Abnormality of T cell physiology (HP:0011840)	1.87572492
74	Abnormal rod and cone electroretinograms (HP:0008323)	1.87113592
75	Stomach cancer (HP:0012126)	1.83854977
76	Basal cell carcinoma (HP:0002671)	1.83210012
77	Cholelithiasis (HP:0001081)	1.82091249
78	Aplasia/Hypoplasia of the patella (HP:0006498)	1.81538961
79	Cerebellar dysplasia (HP:0007033)	1.81494835
80	Inflammation of the large intestine (HP:0002037)	1.80660025
81	Anorexia (HP:0002039)	1.79872268
82	Prolonged partial thromboplastin time (HP:0003645)	1.79805024
83	Chronic hepatic failure (HP:0100626)	1.79313565
84	Abnormality of the renal cortex (HP:0011035)	1.78963585
85	Gastrointestinal inflammation (HP:0004386)	1.78609572
86	Hypertensive crisis (HP:0100735)	1.78561701
87	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.78170264
88	Dicarboxylic aciduria (HP:0003215)	1.78170264
89	Joint hemorrhage (HP:0005261)	1.77184811
90	Hyperventilation (HP:0002883)	1.76789647
91	Abnormality of cells of the erythroid lineage (HP:0012130)	1.76561447
92	Clumsiness (HP:0002312)	1.76062620
93	Renal cortical cysts (HP:0000803)	1.75994148
94	Vasculitis (HP:0002633)	1.74470375
95	Progressive inability to walk (HP:0002505)	1.73766482
96	Supernumerary ribs (HP:0005815)	1.73421983
97	Hypoplasia of the thymus (HP:0000778)	1.72386867
98	Polyneuropathy (HP:0001271)	1.72335939
99	Attenuation of retinal blood vessels (HP:0007843)	1.72184646
100	Hypoplasia of the pons (HP:0012110)	1.71436239

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.94779305
2	MAP4K1	3.35080449
3	MAP4K2	2.91229612
4	TXK	2.87520917
5	GRK6	2.62824351
6	SIK2	2.45169949
7	MAPK15	2.40728658
8	PINK1	2.36310519
9	ZAK	2.11193256
10	BCKDK	2.10119118
11	TNK2	2.02371098
12	MARK3	1.82484948
13	FRK	1.79923205
14	FES	1.73431613
15	CDK12	1.69765004
16	TLK1	1.68334097
17	SYK	1.66580412
18	EPHA3	1.59444614
19	BTK	1.58623852
20	ITK	1.55382200
21	MAP2K3	1.42079120
22	TRIB3	1.37681662
23	MAP3K10	1.35270327
24	MAP2K6	1.34888616
25	KDR	1.25898986
26	ZAP70	1.20785668
27	MAP3K7	1.17491056
28	NEK2	1.15831071
29	CAMKK1	1.11749391
30	IKBKB	1.06738689
31	PASK	1.04565010
32	VRK1	1.03267775
33	MAPK13	1.02374143
34	NME1	0.99686097
35	HCK	0.99636549
36	EEF2K	0.99025439
37	RIPK4	0.97483225
38	CAMKK2	0.97175856
39	EPHB1	0.96762079
40	LCK	0.96752555
41	MAPK12	0.95871639
42	JAK3	0.95257130
43	KIT	0.94871796
44	IKBKE	0.94810478
45	MAP2K7	0.94730286
46	FGFR4	0.93579815
47	CDK4	0.93064404
48	MAP2K2	0.92894561
49	ADRBK2	0.92705358
50	NLK	0.90422827
51	INSRR	0.89339756
52	RPS6KA5	0.88993269
53	MAP3K11	0.88323470
54	PRKCQ	0.88080893
55	TYK2	0.87951860
56	MAPK11	0.87553604
57	DYRK1B	0.85757613
58	LYN	0.83966224
59	DAPK2	0.82301274
60	CDK3	0.77919975
61	PIM1	0.76684065
62	CASK	0.76450127
63	BLK	0.74815942
64	FGFR2	0.73469121
65	MAPKAPK3	0.71313258
66	PRPF4B	0.70865536
67	MATK	0.69608980
68	TAOK1	0.69058997
69	DYRK2	0.68969025
70	ERN1	0.66718358
71	HIPK2	0.65839706
72	MAP2K4	0.62667739
73	TEC	0.62187658
74	ATR	0.61665823
75	JAK2	0.59143977
76	MAP3K4	0.58076440
77	RPS6KA4	0.55143089
78	RPS6KA6	0.53709572
79	NTRK2	0.53644313
80	CHUK	0.53130009
81	CSNK1A1L	0.53112890
82	TESK2	0.52133915
83	CSNK1G3	0.52051084
84	STK16	0.51346231
85	BRD4	0.51315477
86	CDK8	0.49496561
87	PDK1	0.48182294
88	MAPK7	0.47863020
89	RPS6KC1	0.47168355
90	RPS6KL1	0.47168355
91	STK11	0.45320675
92	DYRK3	0.42295179
93	PRKAA1	0.41826214
94	RPS6KA1	0.41777137
95	JAK1	0.39744900
96	TYRO3	0.39359844
97	IRAK1	0.39090369
98	OBSCN	0.38525559
99	CAMK4	0.37112476
100	MARK2	0.37001530

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.41265499
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.43502440
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.36739417
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.28033442
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23748382
6	Butanoate metabolism_Homo sapiens_hsa00650	2.16506190
7	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.06163049
8	ABC transporters_Homo sapiens_hsa02010	2.03796717
9	Homologous recombination_Homo sapiens_hsa03440	1.98091238
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.75394282
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.70535382
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69106892
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.62092875
14	RNA polymerase_Homo sapiens_hsa03020	1.58298490
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.53273102
16	Caffeine metabolism_Homo sapiens_hsa00232	1.50547166
17	Asthma_Homo sapiens_hsa05310	1.50431812
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.49247859
19	Allograft rejection_Homo sapiens_hsa05330	1.46984015
20	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.38316391
21	Phototransduction_Homo sapiens_hsa04744	1.36797064
22	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.36526021
23	Taste transduction_Homo sapiens_hsa04742	1.32910975
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.31916790
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.30974685
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.29552133
27	Regulation of autophagy_Homo sapiens_hsa04140	1.29533368
28	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.25480934
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23374900
30	Base excision repair_Homo sapiens_hsa03410	1.21530822
31	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.17271835
32	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.14779734
33	Retinol metabolism_Homo sapiens_hsa00830	1.14355047
34	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.11426471
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10660475
36	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.10367964
37	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.10024868
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08914242
39	Olfactory transduction_Homo sapiens_hsa04740	1.08173734
40	One carbon pool by folate_Homo sapiens_hsa00670	1.06585173
41	Lysine degradation_Homo sapiens_hsa00310	1.06424127
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04375313
43	Antigen processing and presentation_Homo sapiens_hsa04612	1.03830093
44	Spliceosome_Homo sapiens_hsa03040	1.01944777
45	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.00717413
46	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.99979257
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.99667847
48	Peroxisome_Homo sapiens_hsa04146	0.99012139
49	Nicotine addiction_Homo sapiens_hsa05033	0.97467861
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.97127869
51	Sulfur relay system_Homo sapiens_hsa04122	0.94181391
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93044291
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.86729169
54	DNA replication_Homo sapiens_hsa03030	0.85539490
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83662016
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83131258
57	Complement and coagulation cascades_Homo sapiens_hsa04610	0.82866146
58	Acute myeloid leukemia_Homo sapiens_hsa05221	0.81760436
59	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.79206127
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.78401160
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.78370173
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.77448841
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75421493
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75170170
65	RNA degradation_Homo sapiens_hsa03018	0.68781090
66	Measles_Homo sapiens_hsa05162	0.68642891
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66899713
68	Propanoate metabolism_Homo sapiens_hsa00640	0.65749657
69	Herpes simplex infection_Homo sapiens_hsa05168	0.64579864
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62795777
71	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.62561918
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62542772
73	Osteoclast differentiation_Homo sapiens_hsa04380	0.60031696
74	Malaria_Homo sapiens_hsa05144	0.59274211
75	Leishmaniasis_Homo sapiens_hsa05140	0.58521559
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56833660
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56673288
78	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.54497974
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.54090868
80	African trypanosomiasis_Homo sapiens_hsa05143	0.52889922
81	Type II diabetes mellitus_Homo sapiens_hsa04930	0.52884629
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50891607
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.50721451
84	mTOR signaling pathway_Homo sapiens_hsa04150	0.49065561
85	GABAergic synapse_Homo sapiens_hsa04727	0.49024395
86	Purine metabolism_Homo sapiens_hsa00230	0.48849142
87	Other glycan degradation_Homo sapiens_hsa00511	0.48545833
88	Tryptophan metabolism_Homo sapiens_hsa00380	0.48314274
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.47965231
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47880650
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45846897
92	Insulin resistance_Homo sapiens_hsa04931	0.42304652
93	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40741909
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40297196
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39424811
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39148056
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.38688655
98	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.36420076
99	Ether lipid metabolism_Homo sapiens_hsa00565	0.36210823
100	Morphine addiction_Homo sapiens_hsa05032	0.35550980

CROCCP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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