ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.73886074
2	response to pheromone (GO:0019236)	4.82238180
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.75739040
4	cilium or flagellum-dependent cell motility (GO:0001539)	3.99515374
5	fucose catabolic process (GO:0019317)	3.83713917
6	L-fucose metabolic process (GO:0042354)	3.83713917
7	L-fucose catabolic process (GO:0042355)	3.83713917
8	gamma-aminobutyric acid transport (GO:0015812)	3.83435577
9	epithelial cilium movement (GO:0003351)	3.81709331
10	regulation of cilium movement (GO:0003352)	3.58827827
11	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.56625015
12	regulation of translation, ncRNA-mediated (GO:0045974)	3.56625015
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.56625015
14	cilium movement (GO:0003341)	3.55534847
15	presynaptic membrane organization (GO:0097090)	3.49421327
16	pyrimidine nucleobase catabolic process (GO:0006208)	3.44721785
17	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.41077990
18	axoneme assembly (GO:0035082)	3.25819461
19	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.24528348
20	presynaptic membrane assembly (GO:0097105)	3.20176950
21	auditory behavior (GO:0031223)	3.17244973
22	nonmotile primary cilium assembly (GO:0035058)	3.16309185
23	neural tube formation (GO:0001841)	3.16086074
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.12731131
25	transmission of nerve impulse (GO:0019226)	3.07976392
26	neuronal action potential (GO:0019228)	3.05221657
27	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.03271003
28	membrane depolarization during action potential (GO:0086010)	3.01467260
29	postsynaptic membrane organization (GO:0001941)	2.96664709
30	cilium organization (GO:0044782)	2.95594867
31	nucleobase catabolic process (GO:0046113)	2.93603125
32	protein localization to cilium (GO:0061512)	2.93112842
33	protein polyglutamylation (GO:0018095)	2.91986219
34	mechanosensory behavior (GO:0007638)	2.91462560
35	cilium assembly (GO:0042384)	2.90866388
36	axonemal dynein complex assembly (GO:0070286)	2.86217430
37	glutamate receptor signaling pathway (GO:0007215)	2.85899449
38	detection of light stimulus involved in visual perception (GO:0050908)	2.85349839
39	detection of light stimulus involved in sensory perception (GO:0050962)	2.85349839
40	dendritic spine morphogenesis (GO:0060997)	2.84592617
41	reflex (GO:0060004)	2.84399514
42	retinal cone cell development (GO:0046549)	2.84018339
43	head development (GO:0060322)	2.80287733
44	kidney morphogenesis (GO:0060993)	2.77914592
45	cilium morphogenesis (GO:0060271)	2.75960488
46	regulation of microtubule-based movement (GO:0060632)	2.74377319
47	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.72946837
48	sulfation (GO:0051923)	2.72666668
49	negative regulation of telomere maintenance (GO:0032205)	2.71982122
50	synaptic transmission, cholinergic (GO:0007271)	2.69714154
51	synapse assembly (GO:0007416)	2.68711728
52	urinary tract smooth muscle contraction (GO:0014848)	2.67860751
53	cornea development in camera-type eye (GO:0061303)	2.66764863
54	spinal cord motor neuron differentiation (GO:0021522)	2.66700651
55	behavioral response to ethanol (GO:0048149)	2.64796411
56	cAMP catabolic process (GO:0006198)	2.64734155
57	synaptic transmission, glutamatergic (GO:0035249)	2.64692594
58	neuron cell-cell adhesion (GO:0007158)	2.64196044
59	neuromuscular synaptic transmission (GO:0007274)	2.63960998
60	axon ensheathment in central nervous system (GO:0032291)	2.63897531
61	central nervous system myelination (GO:0022010)	2.63897531
62	cellular ketone body metabolic process (GO:0046950)	2.63712380
63	startle response (GO:0001964)	2.63223365
64	regulation of action potential (GO:0098900)	2.57171969
65	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.57124572
66	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.57093566
67	indolalkylamine metabolic process (GO:0006586)	2.56920999
68	primary amino compound metabolic process (GO:1901160)	2.56389375
69	regulation of telomere maintenance (GO:0032204)	2.55223707
70	intraciliary transport (GO:0042073)	2.54903501
71	DNA deamination (GO:0045006)	2.53449231
72	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.53058999
73	C4-dicarboxylate transport (GO:0015740)	2.51311147
74	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.50582286
75	axonal fasciculation (GO:0007413)	2.50321271
76	tryptophan catabolic process (GO:0006569)	2.48350279
77	indole-containing compound catabolic process (GO:0042436)	2.48350279
78	indolalkylamine catabolic process (GO:0046218)	2.48350279
79	action potential (GO:0001508)	2.48058426
80	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.47250604
81	somite development (GO:0061053)	2.46882071
82	cerebellar Purkinje cell differentiation (GO:0021702)	2.46080745
83	motile cilium assembly (GO:0044458)	2.44240830
84	cyclic nucleotide catabolic process (GO:0009214)	2.43995191
85	cell differentiation in spinal cord (GO:0021515)	2.43724823
86	limb development (GO:0060173)	2.42264608
87	appendage development (GO:0048736)	2.42264608
88	serotonin metabolic process (GO:0042428)	2.41567119
89	glycosphingolipid biosynthetic process (GO:0006688)	2.41512113
90	protein localization to synapse (GO:0035418)	2.38782290
91	positive regulation of CREB transcription factor activity (GO:0032793)	2.38347283
92	photoreceptor cell maintenance (GO:0045494)	2.38215773
93	ketone body metabolic process (GO:1902224)	2.38032825
94	photoreceptor cell development (GO:0042461)	2.37958716
95	cell proliferation in forebrain (GO:0021846)	2.37568149
96	vocalization behavior (GO:0071625)	2.36268086
97	neuronal action potential propagation (GO:0019227)	2.35835968
98	cellular component assembly involved in morphogenesis (GO:0010927)	2.35449466
99	opioid receptor signaling pathway (GO:0038003)	2.33347946
100	nephron tubule morphogenesis (GO:0072078)	2.32869992

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.06895118
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.49767974
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.21873329
4	VDR_22108803_ChIP-Seq_LS180_Human	2.79785945
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.63938368
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51670939
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49395002
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30446425
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30219965
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14183729
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09928979
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.06764522
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.02276130
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99915097
15	FUS_26573619_Chip-Seq_HEK293_Human	1.91381153
16	P300_19829295_ChIP-Seq_ESCs_Human	1.88936094
17	REST_21632747_ChIP-Seq_MESCs_Mouse	1.88838542
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87927279
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.86310061
20	EWS_26573619_Chip-Seq_HEK293_Human	1.84113523
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.76418279
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75487460
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.69610592
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66364291
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.66364291
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65220779
27	STAT3_23295773_ChIP-Seq_U87_Human	1.64789084
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.64506164
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.64259311
30	DROSHA_22980978_ChIP-Seq_HELA_Human	1.64191232
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.63066056
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.60259860
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59691439
34	AR_21572438_ChIP-Seq_LNCaP_Human	1.57657289
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56222628
36	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.54297262
37	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.53798724
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.53351508
39	TCF4_23295773_ChIP-Seq_U87_Human	1.50907738
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49965807
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49726412
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.49298760
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49185779
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48722155
45	AR_25329375_ChIP-Seq_VCAP_Human	1.46970662
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46698466
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45200001
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43859427
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.43491910
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41163495
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40770437
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.39954992
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39954992
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37248224
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35949571
56	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.34225636
57	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.33962375
58	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.31182506
59	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.30639499
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28898427
61	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.28527292
62	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25821047
63	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.25612219
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24940750
65	TP53_16413492_ChIP-PET_HCT116_Human	1.24904278
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24176948
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23994171
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23179286
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.20890105
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19093646
71	* TP53_22573176_ChIP-Seq_HFKS_Human	1.18820710
72	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.18347854
73	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.15732035
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15498194
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14205013
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14203242
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13151949
78	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12995295
79	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.11694514
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11586330
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11559210
82	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10988629
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10447568
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09864092
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09864092
86	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08851911
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08093534
88	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.07897511
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07497294
90	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04556234
91	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02916888
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02801058
93	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02756011
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01832309
95	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.01402175
96	IRF1_19129219_ChIP-ChIP_H3396_Human	1.01127114
97	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.00326261
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99734687
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97740549
100	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.95668809

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.40223728
2	MP0002102_abnormal_ear_morphology	2.91791444
3	MP0001968_abnormal_touch/_nociception	2.75798861
4	MP0003787_abnormal_imprinting	2.54508714
5	MP0008877_abnormal_DNA_methylation	2.43281838
6	MP0003880_abnormal_central_pattern	2.41671821
7	MP0009745_abnormal_behavioral_response	2.24923977
8	MP0005551_abnormal_eye_electrophysiolog	2.17208015
9	MP0002638_abnormal_pupillary_reflex	2.17129914
10	MP0006292_abnormal_olfactory_placode	2.16633590
11	MP0009046_muscle_twitch	2.10628607
12	MP0002272_abnormal_nervous_system	2.03921971
13	MP0005423_abnormal_somatic_nervous	1.98664782
14	MP0003195_calcinosis	1.97212939
15	MP0002735_abnormal_chemical_nociception	1.96503650
16	MP0001486_abnormal_startle_reflex	1.91526591
17	MP0006276_abnormal_autonomic_nervous	1.91289152
18	MP0003136_yellow_coat_color	1.89667364
19	MP0003635_abnormal_synaptic_transmissio	1.88844808
20	MP0004142_abnormal_muscle_tone	1.85769141
21	MP0001984_abnormal_olfaction	1.84280245
22	MP0003646_muscle_fatigue	1.84175650
23	MP0004133_heterotaxia	1.81670006
24	MP0004885_abnormal_endolymph	1.79556011
25	MP0002064_seizures	1.78063164
26	MP0002734_abnormal_mechanical_nocicepti	1.75748408
27	MP0002736_abnormal_nociception_after	1.74718521
28	MP0010386_abnormal_urinary_bladder	1.73712774
29	MP0002653_abnormal_ependyma_morphology	1.73144790
30	MP0001501_abnormal_sleep_pattern	1.68190219
31	MP0002572_abnormal_emotion/affect_behav	1.67769776
32	MP0002063_abnormal_learning/memory/cond	1.64450921
33	MP0001970_abnormal_pain_threshold	1.61537339
34	MP0000778_abnormal_nervous_system	1.61467604
35	MP0001986_abnormal_taste_sensitivity	1.57862648
36	MP0006072_abnormal_retinal_apoptosis	1.55710148
37	MP0001485_abnormal_pinna_reflex	1.54739775
38	MP0008995_early_reproductive_senescence	1.52018697
39	MP0005253_abnormal_eye_physiology	1.51826433
40	MP0004270_analgesia	1.51415135
41	MP0002557_abnormal_social/conspecific_i	1.50754874
42	MP0002067_abnormal_sensory_capabilities	1.50104099
43	MP0002733_abnormal_thermal_nociception	1.48975939
44	MP0002837_dystrophic_cardiac_calcinosis	1.48962279
45	MP0004859_abnormal_synaptic_plasticity	1.48561763
46	MP0000631_abnormal_neuroendocrine_gland	1.47774121
47	MP0003890_abnormal_embryonic-extraembry	1.47070349
48	MP0005646_abnormal_pituitary_gland	1.41737810
49	MP0004742_abnormal_vestibular_system	1.39818480
50	MP0004043_abnormal_pH_regulation	1.38162138
51	MP0000427_abnormal_hair_cycle	1.34191127
52	MP0002184_abnormal_innervation	1.34171639
53	MP0002876_abnormal_thyroid_physiology	1.32887262
54	MP0005645_abnormal_hypothalamus_physiol	1.30527785
55	MP0008872_abnormal_physiological_respon	1.28704447
56	MP0005386_behavior/neurological_phenoty	1.28237187
57	MP0004924_abnormal_behavior	1.28237187
58	MP0002938_white_spotting	1.24832317
59	MP0003121_genomic_imprinting	1.23381645
60	MP0001529_abnormal_vocalization	1.18254763
61	MP0004145_abnormal_muscle_electrophysio	1.15973391
62	MP0002752_abnormal_somatic_nervous	1.15176864
63	MP0005174_abnormal_tail_pigmentation	1.13990415
64	MP0002909_abnormal_adrenal_gland	1.13427753
65	MP0005195_abnormal_posterior_eye	1.09318046
66	MP0002882_abnormal_neuron_morphology	1.07144102
67	MP0000955_abnormal_spinal_cord	1.07014461
68	MP0002751_abnormal_autonomic_nervous	1.03932832
69	MP0000026_abnormal_inner_ear	1.03251807
70	MP0003122_maternal_imprinting	1.02724458
71	MP0002928_abnormal_bile_duct	1.02637465
72	MP0001502_abnormal_circadian_rhythm	1.02286393
73	MP0001963_abnormal_hearing_physiology	1.01271794
74	MP0003119_abnormal_digestive_system	1.00055357
75	MP0008875_abnormal_xenobiotic_pharmacok	0.97871317
76	MP0001905_abnormal_dopamine_level	0.97437970
77	MP0002160_abnormal_reproductive_system	0.97433032
78	MP0003283_abnormal_digestive_organ	0.93639537
79	MP0003137_abnormal_impulse_conducting	0.93537367
80	MP0003938_abnormal_ear_development	0.92831572
81	MP0002822_catalepsy	0.91675178
82	MP0003011_delayed_dark_adaptation	0.91349646
83	MP0000538_abnormal_urinary_bladder	0.89758565
84	MP0005187_abnormal_penis_morphology	0.88297088
85	MP0001324_abnormal_eye_pigmentation	0.88284423
86	MP0000566_synostosis	0.88146352
87	MP0000372_irregular_coat_pigmentation	0.87897168
88	MP0002229_neurodegeneration	0.87736965
89	MP0005389_reproductive_system_phenotype	0.86038610
90	MP0001440_abnormal_grooming_behavior	0.85775477
91	MP0000049_abnormal_middle_ear	0.80656549
92	MP0003698_abnormal_male_reproductive	0.80395400
93	MP0001188_hyperpigmentation	0.79804196
94	MP0004130_abnormal_muscle_cell	0.79595744
95	MP0000383_abnormal_hair_follicle	0.77165443
96	MP0002152_abnormal_brain_morphology	0.75888684
97	MP0003878_abnormal_ear_physiology	0.73196490
98	MP0005377_hearing/vestibular/ear_phenot	0.73196490
99	MP0005448_abnormal_energy_balance	0.73102614
100	MP0002066_abnormal_motor_capabilities/c	0.72578255

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.54531539
2	Molar tooth sign on MRI (HP:0002419)	4.31912068
3	Abnormality of midbrain morphology (HP:0002418)	4.31912068
4	Pancreatic fibrosis (HP:0100732)	4.20235228
5	True hermaphroditism (HP:0010459)	4.19435778
6	Chronic hepatic failure (HP:0100626)	3.90912192
7	Hyperventilation (HP:0002883)	3.83011024
8	Nephronophthisis (HP:0000090)	3.82510134
9	Absent/shortened dynein arms (HP:0200106)	3.48162367
10	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.48162367
11	Congenital stationary night blindness (HP:0007642)	3.37737557
12	Abnormality of the renal cortex (HP:0011035)	3.28162517
13	Abnormality of the renal medulla (HP:0100957)	3.28140253
14	Medial flaring of the eyebrow (HP:0010747)	3.07919472
15	Progressive cerebellar ataxia (HP:0002073)	3.06424428
16	Genetic anticipation (HP:0003743)	3.06047090
17	Cystic liver disease (HP:0006706)	3.01206158
18	Abnormal respiratory epithelium morphology (HP:0012253)	3.00007496
19	Abnormal respiratory motile cilium morphology (HP:0005938)	3.00007496
20	Inability to walk (HP:0002540)	2.97136082
21	Protruding tongue (HP:0010808)	2.91095099
22	Type II lissencephaly (HP:0007260)	2.85366103
23	Gaze-evoked nystagmus (HP:0000640)	2.79508311
24	Gait imbalance (HP:0002141)	2.78951516
25	Abnormal drinking behavior (HP:0030082)	2.78647394
26	Polydipsia (HP:0001959)	2.78647394
27	Abnormal ciliary motility (HP:0012262)	2.74043424
28	Stomach cancer (HP:0012126)	2.72455518
29	Broad-based gait (HP:0002136)	2.71857030
30	Progressive inability to walk (HP:0002505)	2.63722709
31	Absent speech (HP:0001344)	2.56006231
32	Congenital primary aphakia (HP:0007707)	2.55672566
33	Tubular atrophy (HP:0000092)	2.48890781
34	Decreased circulating renin level (HP:0003351)	2.44593751
35	Focal motor seizures (HP:0011153)	2.42766844
36	Febrile seizures (HP:0002373)	2.40296557
37	Focal seizures (HP:0007359)	2.37981657
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.35760171
39	Nephrogenic diabetes insipidus (HP:0009806)	2.35545508
40	Congenital hepatic fibrosis (HP:0002612)	2.35349921
41	Abolished electroretinogram (ERG) (HP:0000550)	2.34713747
42	Male pseudohermaphroditism (HP:0000037)	2.32471000
43	Anencephaly (HP:0002323)	2.31714819
44	Sclerocornea (HP:0000647)	2.31705253
45	Abnormal respiratory motile cilium physiology (HP:0012261)	2.30832430
46	Renal cortical cysts (HP:0000803)	2.30253029
47	Attenuation of retinal blood vessels (HP:0007843)	2.29643750
48	Lissencephaly (HP:0001339)	2.28482564
49	Genital tract atresia (HP:0001827)	2.27137955
50	Cerebellar dysplasia (HP:0007033)	2.26856009
51	Vaginal atresia (HP:0000148)	2.25481043
52	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.25319570
53	Pendular nystagmus (HP:0012043)	2.18363780
54	Polyuria (HP:0000103)	2.16683267
55	Limb dystonia (HP:0002451)	2.12459379
56	Occipital encephalocele (HP:0002085)	2.11774423
57	Furrowed tongue (HP:0000221)	2.06465985
58	Optic nerve hypoplasia (HP:0000609)	2.06301245
59	Dialeptic seizures (HP:0011146)	2.06125177
60	Large for gestational age (HP:0001520)	2.04250367
61	Poor coordination (HP:0002370)	2.04083556
62	Patellar aplasia (HP:0006443)	2.03541415
63	Clumsiness (HP:0002312)	2.00603261
64	Oligodactyly (hands) (HP:0001180)	1.99973656
65	Postaxial foot polydactyly (HP:0001830)	1.98588839
66	Volvulus (HP:0002580)	1.98190967
67	Abnormal rod and cone electroretinograms (HP:0008323)	1.96066735
68	Drooling (HP:0002307)	1.94246876
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93393695
70	Bony spicule pigmentary retinopathy (HP:0007737)	1.92216420
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92081385
72	Retinal dysplasia (HP:0007973)	1.87945307
73	Prolonged QT interval (HP:0001657)	1.86703547
74	Aplasia/Hypoplasia of the patella (HP:0006498)	1.86007576
75	Rhinitis (HP:0012384)	1.84999629
76	Hypothermia (HP:0002045)	1.83951495
77	Bile duct proliferation (HP:0001408)	1.82823398
78	Abnormal biliary tract physiology (HP:0012439)	1.82823398
79	Abnormality of the labia minora (HP:0012880)	1.82515028
80	Postaxial hand polydactyly (HP:0001162)	1.82492124
81	Epileptic encephalopathy (HP:0200134)	1.82041028
82	Increased corneal curvature (HP:0100692)	1.79274659
83	Keratoconus (HP:0000563)	1.79274659
84	Excessive salivation (HP:0003781)	1.76762302
85	Atonic seizures (HP:0010819)	1.76312074
86	Narrow forehead (HP:0000341)	1.75745185
87	Anterior segment dysgenesis (HP:0007700)	1.74916830
88	Hemiparesis (HP:0001269)	1.74064571
89	Thyroid-stimulating hormone excess (HP:0002925)	1.73713046
90	Pachygyria (HP:0001302)	1.73712014
91	Agitation (HP:0000713)	1.71233286
92	Fair hair (HP:0002286)	1.70537327
93	Intestinal atresia (HP:0011100)	1.70239674
94	Decreased central vision (HP:0007663)	1.69516866
95	Chorioretinal atrophy (HP:0000533)	1.69317838
96	Abnormal urine output (HP:0012590)	1.68089804
97	Abnormality of alanine metabolism (HP:0010916)	1.67928552
98	Hyperalaninemia (HP:0003348)	1.67928552
99	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.67928552
100	Preaxial hand polydactyly (HP:0001177)	1.67586910

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.27488953
2	CASK	3.49845401
3	ADRBK2	3.09803776
4	BMPR1B	2.73685970
5	TLK1	2.68750307
6	WNK3	2.66922446
7	MAPK13	2.46213357
8	PINK1	2.44878563
9	ACVR1B	2.35298505
10	MAP4K2	2.18263731
11	NTRK3	2.09353875
12	MARK1	2.03999900
13	WNK4	1.91975618
14	GRK1	1.87296902
15	MAP3K4	1.79380563
16	INSRR	1.75467008
17	ZAK	1.73008054
18	FGFR2	1.65407724
19	NUAK1	1.59934274
20	DAPK2	1.54940402
21	TNIK	1.50692541
22	NTRK2	1.48267233
23	TAOK3	1.38111551
24	PAK3	1.37369914
25	SIK2	1.32499907
26	MAP2K7	1.27165011
27	MAP2K6	1.26048363
28	ADRBK1	1.25640133
29	EPHA4	1.24622977
30	DYRK2	1.24045748
31	OXSR1	1.18324037
32	MAPK15	1.18133888
33	MKNK2	1.16975301
34	NEK2	1.14756081
35	STK39	1.12731166
36	CAMKK2	1.06922125
37	PRKCG	1.02318437
38	NEK1	0.95979895
39	BCR	0.92687698
40	CSNK1G2	0.87594746
41	TRIM28	0.87565795
42	SGK2	0.84959476
43	TGFBR1	0.84107217
44	TXK	0.83511908
45	PRKCE	0.81931094
46	TIE1	0.79226063
47	ERBB2	0.77851045
48	DYRK1A	0.77509730
49	STK11	0.76910207
50	PNCK	0.73527434
51	PLK2	0.72560537
52	PKN1	0.72429221
53	SGK494	0.71342987
54	SGK223	0.71342987
55	CSNK1G1	0.70305617
56	TNK2	0.70286125
57	CSNK1A1L	0.69387715
58	MAP2K4	0.67528027
59	NLK	0.65137386
60	TEC	0.65042552
61	CAMK1	0.65034614
62	WNK1	0.64515333
63	CAMKK1	0.64139329
64	PTK2B	0.63889817
65	CAMK1D	0.62832332
66	CAMK1G	0.61546817
67	CAMK2A	0.58802033
68	STK38L	0.58425793
69	CSNK1G3	0.56980859
70	MAPKAPK5	0.56381121
71	DYRK3	0.54587719
72	MARK3	0.54104501
73	CAMK4	0.52078081
74	ITK	0.49419351
75	PRKCQ	0.49134902
76	NME1	0.49094990
77	PHKG2	0.48500772
78	PHKG1	0.48500772
79	MINK1	0.47789413
80	PRKAA1	0.46062875
81	OBSCN	0.45051845
82	PRKACA	0.44830962
83	CSNK1D	0.43563840
84	STK3	0.43424134
85	RPS6KA5	0.43171126
86	AKT3	0.42698825
87	UHMK1	0.42237421
88	CDK5	0.40824857
89	PRKCZ	0.40682171
90	CSNK1A1	0.40029152
91	PIK3CA	0.38827493
92	SGK1	0.37581025
93	PRKCH	0.37338860
94	EPHA3	0.36018385
95	PRKACB	0.35855604
96	MUSK	0.35673896
97	PRKG1	0.35363377
98	MAP3K7	0.35049879
99	BRSK2	0.33976776
100	MAPKAPK3	0.33537691

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.80240940
2	Phototransduction_Homo sapiens_hsa04744	2.71004358
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.51302973
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.44157448
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.35854955
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.23397438
7	Morphine addiction_Homo sapiens_hsa05032	2.21434209
8	Taste transduction_Homo sapiens_hsa04742	2.17284919
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.14899950
10	Circadian entrainment_Homo sapiens_hsa04713	2.07771425
11	Butanoate metabolism_Homo sapiens_hsa00650	2.02204992
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.99676796
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.97023944
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.96345918
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.90526162
16	GABAergic synapse_Homo sapiens_hsa04727	1.85048033
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.84307625
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.70569682
19	Olfactory transduction_Homo sapiens_hsa04740	1.70266203
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.64259187
21	Insulin secretion_Homo sapiens_hsa04911	1.52708381
22	ABC transporters_Homo sapiens_hsa02010	1.52666485
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.52019498
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.44647998
25	Basal transcription factors_Homo sapiens_hsa03022	1.40501724
26	Serotonergic synapse_Homo sapiens_hsa04726	1.39427136
27	Dopaminergic synapse_Homo sapiens_hsa04728	1.38414809
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38383730
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.35687611
30	Regulation of autophagy_Homo sapiens_hsa04140	1.32362777
31	Homologous recombination_Homo sapiens_hsa03440	1.23237211
32	Amphetamine addiction_Homo sapiens_hsa05031	1.23153093
33	Calcium signaling pathway_Homo sapiens_hsa04020	1.21943298
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.21639717
35	Salivary secretion_Homo sapiens_hsa04970	1.19764144
36	Cholinergic synapse_Homo sapiens_hsa04725	1.19192225
37	Cocaine addiction_Homo sapiens_hsa05030	1.14894065
38	Long-term depression_Homo sapiens_hsa04730	1.13801312
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12136653
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.09314640
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.07196944
42	Oxidative phosphorylation_Homo sapiens_hsa00190	1.03236744
43	Gastric acid secretion_Homo sapiens_hsa04971	1.01156195
44	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.00264046
45	RNA polymerase_Homo sapiens_hsa03020	0.98750283
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.95374131
47	Caffeine metabolism_Homo sapiens_hsa00232	0.95081375
48	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.91224559
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.90015487
50	Circadian rhythm_Homo sapiens_hsa04710	0.87588222
51	Axon guidance_Homo sapiens_hsa04360	0.86698183
52	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.86046666
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.84299077
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83935852
55	Propanoate metabolism_Homo sapiens_hsa00640	0.81423849
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79127341
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78894746
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78008868
59	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.77237082
60	Peroxisome_Homo sapiens_hsa04146	0.76794373
61	Protein export_Homo sapiens_hsa03060	0.74762000
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72675506
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.72126978
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71954531
65	Parkinsons disease_Homo sapiens_hsa05012	0.71664125
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70385022
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.69610377
68	Histidine metabolism_Homo sapiens_hsa00340	0.68126429
69	Renin secretion_Homo sapiens_hsa04924	0.67563951
70	RNA degradation_Homo sapiens_hsa03018	0.67462678
71	Retinol metabolism_Homo sapiens_hsa00830	0.64896786
72	Huntingtons disease_Homo sapiens_hsa05016	0.64374727
73	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.61752067
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.61255361
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60910348
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58698588
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56977589
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56264003
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.53469569
80	Alzheimers disease_Homo sapiens_hsa05010	0.53237503
81	Type II diabetes mellitus_Homo sapiens_hsa04930	0.51704938
82	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51101040
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49542224
84	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.48269225
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47108354
86	Ras signaling pathway_Homo sapiens_hsa04014	0.46221095
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.44156968
88	Primary immunodeficiency_Homo sapiens_hsa05340	0.44115571
89	MAPK signaling pathway_Homo sapiens_hsa04010	0.42596501
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.40446626
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38612152
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37284001
93	Pancreatic secretion_Homo sapiens_hsa04972	0.37265816
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.35691780
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.34842500
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31974279
97	Hippo signaling pathway_Homo sapiens_hsa04390	0.30008834
98	Lysine degradation_Homo sapiens_hsa00310	0.28566700
99	Melanogenesis_Homo sapiens_hsa04916	0.28489831
100	Purine metabolism_Homo sapiens_hsa00230	0.27040228

CROCCP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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