ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.26357656
2	protein-cofactor linkage (GO:0018065)	3.89596029
3	meiotic chromosome segregation (GO:0045132)	3.87781932
4	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.75686644
5	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.73960720
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.66143246
7	ATP synthesis coupled proton transport (GO:0015986)	3.66143246
8	spliceosomal snRNP assembly (GO:0000387)	3.65394900
9	DNA damage response, detection of DNA damage (GO:0042769)	3.58355522
10	DNA integration (GO:0015074)	3.55868310
11	NADH dehydrogenase complex assembly (GO:0010257)	3.54298094
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54298094
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54298094
14	mismatch repair (GO:0006298)	3.53003955
15	behavioral response to nicotine (GO:0035095)	3.50199621
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.48026301
17	rRNA modification (GO:0000154)	3.43654626
18	peptidyl-arginine methylation (GO:0018216)	3.38111053
19	peptidyl-arginine N-methylation (GO:0035246)	3.38111053
20	positive regulation of mitochondrial fission (GO:0090141)	3.34556052
21	protein localization to cilium (GO:0061512)	3.31728213
22	mitochondrial RNA metabolic process (GO:0000959)	3.30954153
23	peptidyl-arginine omega-N-methylation (GO:0035247)	3.30724060
24	somite development (GO:0061053)	3.30720721
25	DNA deamination (GO:0045006)	3.28496443
26	reciprocal DNA recombination (GO:0035825)	3.23699286
27	reciprocal meiotic recombination (GO:0007131)	3.23699286
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.17009354
29	base-excision repair, AP site formation (GO:0006285)	3.16928405
30	protein complex biogenesis (GO:0070271)	3.13021115
31	nonmotile primary cilium assembly (GO:0035058)	3.12544744
32	protein polyglutamylation (GO:0018095)	3.12175318
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.11379392
34	pyrimidine nucleobase catabolic process (GO:0006208)	3.10698743
35	chromatin remodeling at centromere (GO:0031055)	3.08791362
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.07375791
37	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.07375791
38	intraciliary transport (GO:0042073)	3.02424300
39	preassembly of GPI anchor in ER membrane (GO:0016254)	3.01457088
40	C-terminal protein lipidation (GO:0006501)	3.01293990
41	protein neddylation (GO:0045116)	3.00054606
42	sequestering of actin monomers (GO:0042989)	2.98988770
43	positive regulation of prostaglandin secretion (GO:0032308)	2.95326019
44	adenosine metabolic process (GO:0046085)	2.94375830
45	DNA topological change (GO:0006265)	2.92397282
46	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.91374344
47	regulation of mitotic spindle checkpoint (GO:1903504)	2.91374344
48	gamma-aminobutyric acid transport (GO:0015812)	2.91365890
49	cullin deneddylation (GO:0010388)	2.90560325
50	purine nucleobase biosynthetic process (GO:0009113)	2.89162888
51	nucleobase biosynthetic process (GO:0046112)	2.86776174
52	regulation of mitochondrial translation (GO:0070129)	2.84710858
53	C-terminal protein amino acid modification (GO:0018410)	2.83090844
54	chaperone-mediated protein transport (GO:0072321)	2.82904923
55	regulation of helicase activity (GO:0051095)	2.82045265
56	retinal ganglion cell axon guidance (GO:0031290)	2.77722721
57	proteasome assembly (GO:0043248)	2.77278158
58	respiratory electron transport chain (GO:0022904)	2.76667214
59	histone arginine methylation (GO:0034969)	2.73925042
60	purine deoxyribonucleotide catabolic process (GO:0009155)	2.72306336
61	electron transport chain (GO:0022900)	2.71062773
62	translesion synthesis (GO:0019985)	2.70780652
63	fucose catabolic process (GO:0019317)	2.70408844
64	L-fucose metabolic process (GO:0042354)	2.70408844
65	L-fucose catabolic process (GO:0042355)	2.70408844
66	rRNA methylation (GO:0031167)	2.70014849
67	maturation of 5.8S rRNA (GO:0000460)	2.69547025
68	oxidative phosphorylation (GO:0006119)	2.69302813
69	photoreceptor cell maintenance (GO:0045494)	2.67962378
70	CENP-A containing nucleosome assembly (GO:0034080)	2.66846758
71	metallo-sulfur cluster assembly (GO:0031163)	2.66844301
72	iron-sulfur cluster assembly (GO:0016226)	2.66844301
73	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.65963626
74	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.65963626
75	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.65056958
76	platelet dense granule organization (GO:0060155)	2.64067521
77	pseudouridine synthesis (GO:0001522)	2.63474816
78	water-soluble vitamin biosynthetic process (GO:0042364)	2.63434645
79	snRNA processing (GO:0016180)	2.63036900
80	microtubule severing (GO:0051013)	2.62602237
81	termination of RNA polymerase III transcription (GO:0006386)	2.61981381
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.61981381
83	neural tube formation (GO:0001841)	2.61261040
84	DNA replication checkpoint (GO:0000076)	2.60679548
85	cilium morphogenesis (GO:0060271)	2.60165802
86	histone mRNA metabolic process (GO:0008334)	2.59510476
87	GPI anchor metabolic process (GO:0006505)	2.58433300
88	spliceosomal complex assembly (GO:0000245)	2.56624501
89	peptidyl-histidine modification (GO:0018202)	2.54763978
90	deoxyribonucleotide catabolic process (GO:0009264)	2.53870715
91	presynaptic membrane assembly (GO:0097105)	2.53240826
92	protein K11-linked deubiquitination (GO:0035871)	2.49771945
93	protein K6-linked ubiquitination (GO:0085020)	2.49106130
94	transcription from mitochondrial promoter (GO:0006390)	2.47939331
95	DNA double-strand break processing (GO:0000729)	2.47586894
96	tRNA processing (GO:0008033)	2.46340443
97	ubiquinone metabolic process (GO:0006743)	2.45055772
98	termination of RNA polymerase II transcription (GO:0006369)	2.44178003
99	protein deneddylation (GO:0000338)	2.43830170
100	postreplication repair (GO:0006301)	2.40822507

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.59544539
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.52597500
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.33949365
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.22422977
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.20998490
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.14340426
7	IGF1R_20145208_ChIP-Seq_DFB_Human	3.08940837
8	ZNF274_21170338_ChIP-Seq_K562_Hela	3.06098478
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.84638616
10	FUS_26573619_Chip-Seq_HEK293_Human	2.49927898
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.47993994
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.32225447
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.31489478
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30743227
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.28983253
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.19714421
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.13231057
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.12004122
19	EWS_26573619_Chip-Seq_HEK293_Human	2.06425166
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.03141458
21	MYC_18940864_ChIP-ChIP_HL60_Human	2.02611552
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.01881735
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.96848708
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.93247056
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.91834947
26	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.87717438
27	VDR_22108803_ChIP-Seq_LS180_Human	1.81148385
28	EZH2_22144423_ChIP-Seq_EOC_Human	1.80600857
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78377315
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73659061
31	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.66277007
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.64626542
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62462771
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61363913
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61164452
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60696674
37	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.58544462
38	E2F7_22180533_ChIP-Seq_HELA_Human	1.57897024
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.57140952
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.54399308
41	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.54329344
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50008195
43	GABP_19822575_ChIP-Seq_HepG2_Human	1.47066114
44	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.46894065
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46398289
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.42526637
47	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42417517
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.42121697
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.41789871
50	P300_19829295_ChIP-Seq_ESCs_Human	1.35928592
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.33784980
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33051521
53	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.31998297
54	XRN2_22483619_ChIP-Seq_HELA_Human	1.28837680
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28141677
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.28141677
57	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.26874732
58	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25058217
59	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.24530958
60	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.23246204
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21034091
62	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.20988017
63	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17868494
64	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.17695073
65	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.14871122
66	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.13938262
67	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.08699572
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06450729
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05790380
70	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.03910253
71	CIITA_25753668_ChIP-Seq_RAJI_Human	1.00102857
72	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.99748064
73	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.98643621
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98032866
75	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.96480195
76	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.96451258
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95836761
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94198614
79	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.92572625
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92104241
81	ER_23166858_ChIP-Seq_MCF-7_Human	0.91463622
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91206892
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91117142
84	REST_21632747_ChIP-Seq_MESCs_Mouse	0.88909393
85	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.85750577
86	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.85613754
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.85319229
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.85319229
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.85167774
90	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85070882
91	NCOR_22424771_ChIP-Seq_293T_Human	0.84886613
92	AR_20517297_ChIP-Seq_VCAP_Human	0.83951181
93	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.83832420
94	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.83461393
95	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.82866931
96	KDM5A_27292631_Chip-Seq_BREAST_Human	0.81256852
97	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.81161213
98	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.80856714
99	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.80543537
100	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.80045716

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	3.37823887
2	MP0002653_abnormal_ependyma_morphology	3.00004849
3	MP0008877_abnormal_DNA_methylation	2.64203015
4	MP0002822_catalepsy	2.61537102
5	MP0006292_abnormal_olfactory_placode	2.55176331
6	MP0008058_abnormal_DNA_repair	2.42262529
7	MP0002102_abnormal_ear_morphology	2.33998772
8	MP0006072_abnormal_retinal_apoptosis	2.29802349
9	MP0004147_increased_porphyrin_level	2.21593205
10	MP0003011_delayed_dark_adaptation	2.18225502
11	MP0001984_abnormal_olfaction	2.15643493
12	MP0006276_abnormal_autonomic_nervous	2.02403637
13	MP0009379_abnormal_foot_pigmentation	1.95613462
14	MP0003880_abnormal_central_pattern	1.82962383
15	MP0008789_abnormal_olfactory_epithelium	1.82856889
16	MP0005253_abnormal_eye_physiology	1.80802534
17	MP0004133_heterotaxia	1.80287744
18	MP0003718_maternal_effect	1.76025134
19	MP0001529_abnormal_vocalization	1.72190997
20	MP0002736_abnormal_nociception_after	1.68083544
21	MP0004043_abnormal_pH_regulation	1.67226502
22	MP0001293_anophthalmia	1.61305579
23	MP0005551_abnormal_eye_electrophysiolog	1.60913737
24	MP0002234_abnormal_pharynx_morphology	1.58384746
25	MP0002735_abnormal_chemical_nociception	1.56609321
26	MP0001968_abnormal_touch/_nociception	1.54018641
27	MP0000631_abnormal_neuroendocrine_gland	1.52857225
28	MP0010094_abnormal_chromosome_stability	1.51701689
29	MP0003693_abnormal_embryo_hatching	1.51169547
30	MP0001986_abnormal_taste_sensitivity	1.48911882
31	MP0008995_early_reproductive_senescence	1.48879379
32	MP0002938_white_spotting	1.46871160
33	MP0000778_abnormal_nervous_system	1.45950570
34	MP0009745_abnormal_behavioral_response	1.45903248
35	MP0005394_taste/olfaction_phenotype	1.43787941
36	MP0005499_abnormal_olfactory_system	1.43787941
37	MP0003567_abnormal_fetal_cardiomyocyte	1.39772666
38	MP0005646_abnormal_pituitary_gland	1.37198228
39	MP0003941_abnormal_skin_development	1.35292558
40	MP0005423_abnormal_somatic_nervous	1.34360454
41	MP0008932_abnormal_embryonic_tissue	1.33841506
42	MP0002751_abnormal_autonomic_nervous	1.33388347
43	MP0000049_abnormal_middle_ear	1.33253417
44	MP0004142_abnormal_muscle_tone	1.32944116
45	MP0006035_abnormal_mitochondrial_morpho	1.32323110
46	MP0003221_abnormal_cardiomyocyte_apopto	1.31487530
47	MP0003122_maternal_imprinting	1.25422984
48	MP0003111_abnormal_nucleus_morphology	1.20272659
49	MP0002734_abnormal_mechanical_nocicepti	1.19774760
50	MP0004859_abnormal_synaptic_plasticity	1.19509039
51	MP0003635_abnormal_synaptic_transmissio	1.17121560
52	MP0002160_abnormal_reproductive_system	1.15412773
53	MP0002090_abnormal_vision	1.15409243
54	MP0003136_yellow_coat_color	1.15340052
55	MP0004484_altered_response_of	1.14356195
56	MP0003195_calcinosis	1.14319734
57	MP0009046_muscle_twitch	1.13421089
58	MP0005085_abnormal_gallbladder_physiolo	1.13291284
59	MP0004145_abnormal_muscle_electrophysio	1.12226126
60	MP0003878_abnormal_ear_physiology	1.10331894
61	MP0005377_hearing/vestibular/ear_phenot	1.10331894
62	MP0002572_abnormal_emotion/affect_behav	1.09230062
63	MP0003937_abnormal_limbs/digits/tail_de	1.08448866
64	MP0003698_abnormal_male_reproductive	1.07834561
65	MP0001188_hyperpigmentation	1.07532931
66	MP0004270_analgesia	1.07174832
67	MP0002064_seizures	1.06936904
68	MP0002210_abnormal_sex_determination	1.06068169
69	MP0005187_abnormal_penis_morphology	1.05965880
70	MP0000026_abnormal_inner_ear	1.05494605
71	MP0000647_abnormal_sebaceous_gland	1.04584479
72	MP0003119_abnormal_digestive_system	1.03079365
73	MP0005391_vision/eye_phenotype	1.00215172
74	MP0001764_abnormal_homeostasis	0.99678169
75	MP0003121_genomic_imprinting	0.99059671
76	MP0006036_abnormal_mitochondrial_physio	0.97185662
77	MP0003077_abnormal_cell_cycle	0.96951253
78	MP0001970_abnormal_pain_threshold	0.96197119
79	MP0001929_abnormal_gametogenesis	0.95368882
80	MP0002272_abnormal_nervous_system	0.95030956
81	MP0005195_abnormal_posterior_eye	0.93984622
82	MP0003938_abnormal_ear_development	0.93788136
83	MP0005389_reproductive_system_phenotype	0.93646992
84	MP0003786_premature_aging	0.93173018
85	MP0002063_abnormal_learning/memory/cond	0.91977753
86	MP0001486_abnormal_startle_reflex	0.91587953
87	MP0004742_abnormal_vestibular_system	0.91357624
88	MP0002557_abnormal_social/conspecific_i	0.88625181
89	MP0002752_abnormal_somatic_nervous	0.88358367
90	MP0002184_abnormal_innervation	0.87719864
91	MP0003315_abnormal_perineum_morphology	0.87114559
92	MP0005167_abnormal_blood-brain_barrier	0.86586137
93	MP0003137_abnormal_impulse_conducting	0.85833150
94	MP0000653_abnormal_sex_gland	0.85666211
95	MP0008875_abnormal_xenobiotic_pharmacok	0.85495443
96	MP0001145_abnormal_male_reproductive	0.85350884
97	MP0001286_abnormal_eye_development	0.84069559
98	MP0002282_abnormal_trachea_morphology	0.83444978
99	MP0000537_abnormal_urethra_morphology	0.83333719
100	MP0002928_abnormal_bile_duct	0.81286811

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.64815356
2	Pancreatic cysts (HP:0001737)	3.44917014
3	True hermaphroditism (HP:0010459)	3.42324566
4	Pancreatic fibrosis (HP:0100732)	3.35192007
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.20254861
6	Mitochondrial inheritance (HP:0001427)	3.16473423
7	Lipid accumulation in hepatocytes (HP:0006561)	3.13387993
8	Increased hepatocellular lipid droplets (HP:0006565)	3.08544250
9	Acute encephalopathy (HP:0006846)	3.03412611
10	Hepatocellular necrosis (HP:0001404)	2.98958483
11	Abnormal number of erythroid precursors (HP:0012131)	2.97311797
12	Colon cancer (HP:0003003)	2.92261038
13	Nephronophthisis (HP:0000090)	2.86694771
14	Progressive macrocephaly (HP:0004481)	2.86617181
15	Increased CSF lactate (HP:0002490)	2.85619731
16	Medial flaring of the eyebrow (HP:0010747)	2.77533407
17	Hepatic necrosis (HP:0002605)	2.76472816
18	Gait imbalance (HP:0002141)	2.74063355
19	Congenital primary aphakia (HP:0007707)	2.72059065
20	Abnormality of midbrain morphology (HP:0002418)	2.65067359
21	Molar tooth sign on MRI (HP:0002419)	2.65067359
22	Abnormality of cells of the erythroid lineage (HP:0012130)	2.43606461
23	Nephrogenic diabetes insipidus (HP:0009806)	2.42671482
24	Cerebral edema (HP:0002181)	2.42281222
25	Sclerocornea (HP:0000647)	2.42170518
26	Increased serum lactate (HP:0002151)	2.35288520
27	Abnormality of the labia minora (HP:0012880)	2.35064557
28	Vaginal atresia (HP:0000148)	2.32022989
29	Postaxial foot polydactyly (HP:0001830)	2.31153075
30	Renal Fanconi syndrome (HP:0001994)	2.31078905
31	Supernumerary spleens (HP:0009799)	2.29308286
32	Cystic liver disease (HP:0006706)	2.26468281
33	Genital tract atresia (HP:0001827)	2.25886175
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.25469471
35	Pendular nystagmus (HP:0012043)	2.20556312
36	Methylmalonic acidemia (HP:0002912)	2.20097403
37	Abnormality of alanine metabolism (HP:0010916)	2.19627819
38	Hyperalaninemia (HP:0003348)	2.19627819
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.19627819
40	Meckel diverticulum (HP:0002245)	2.18752223
41	Hyperglycinemia (HP:0002154)	2.16034007
42	Type 2 muscle fiber atrophy (HP:0003554)	2.13246162
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.12216521
44	Abnormality of the ileum (HP:0001549)	2.11141222
45	Septo-optic dysplasia (HP:0100842)	2.11010673
46	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.10612783
47	Anencephaly (HP:0002323)	2.10288885
48	Chronic hepatic failure (HP:0100626)	2.08218328
49	Abolished electroretinogram (ERG) (HP:0000550)	2.07928039
50	Lactic acidosis (HP:0003128)	2.07681836
51	Muscle fiber atrophy (HP:0100295)	2.05584332
52	Abnormality of the renal medulla (HP:0100957)	2.01167071
53	Thyroid-stimulating hormone excess (HP:0002925)	1.98637309
54	Optic disc pallor (HP:0000543)	1.96609446
55	Optic nerve hypoplasia (HP:0000609)	1.96384170
56	Methylmalonic aciduria (HP:0012120)	1.94909185
57	Postaxial hand polydactyly (HP:0001162)	1.94466254
58	Preaxial hand polydactyly (HP:0001177)	1.93153952
59	Intestinal atresia (HP:0011100)	1.92334346
60	Bilateral microphthalmos (HP:0007633)	1.92147164
61	Reticulocytopenia (HP:0001896)	1.91499240
62	Poor head control (HP:0002421)	1.90681133
63	Male pseudohermaphroditism (HP:0000037)	1.89937459
64	Progressive inability to walk (HP:0002505)	1.89195546
65	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89084040
66	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.88166578
67	Poor coordination (HP:0002370)	1.86330208
68	Abnormal lung lobation (HP:0002101)	1.86196903
69	Bony spicule pigmentary retinopathy (HP:0007737)	1.86105529
70	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.85803401
71	Inability to walk (HP:0002540)	1.84980846
72	Anophthalmia (HP:0000528)	1.84449848
73	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.80424667
74	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.80424667
75	Abnormal glycosylation (HP:0012345)	1.80034863
76	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.80034863
77	Abnormal protein N-linked glycosylation (HP:0012347)	1.80034863
78	Abnormal protein glycosylation (HP:0012346)	1.80034863
79	Retinitis pigmentosa (HP:0000510)	1.79465604
80	Lethargy (HP:0001254)	1.78113883
81	Shoulder girdle muscle weakness (HP:0003547)	1.78010098
82	Astigmatism (HP:0000483)	1.77906688
83	Patellar aplasia (HP:0006443)	1.77267090
84	Dicarboxylic aciduria (HP:0003215)	1.74663518
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.74663518
86	Attenuation of retinal blood vessels (HP:0007843)	1.73910132
87	Abnormality of the hip-girdle musculature (HP:0001445)	1.70354019
88	Abnormality of the musculature of the pelvis (HP:0001469)	1.70354019
89	Aplasia/Hypoplasia of the patella (HP:0006498)	1.70017725
90	Chronic bronchitis (HP:0004469)	1.68943402
91	Decreased testicular size (HP:0008734)	1.67939730
92	Congenital, generalized hypertrichosis (HP:0004540)	1.66560329
93	Exercise intolerance (HP:0003546)	1.66139014
94	Increased intramyocellular lipid droplets (HP:0012240)	1.65735849
95	Bifid tongue (HP:0010297)	1.63880748
96	Progressive microcephaly (HP:0000253)	1.63354452
97	Congenital hepatic fibrosis (HP:0002612)	1.63155899
98	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.62617688
99	Abnormal biliary tract physiology (HP:0012439)	1.62022090
100	Bile duct proliferation (HP:0001408)	1.62022090

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.47347636
2	MAP4K2	3.42568207
3	CDK19	3.19093427
4	CDC7	2.99295084
5	NUAK1	2.93615505
6	SRPK1	2.86555799
7	MAP3K4	2.68419189
8	WNK3	2.53261537
9	MAP2K7	2.38335395
10	BCKDK	2.35425033
11	DYRK2	2.30135610
12	ZAK	2.18304389
13	CASK	2.05895486
14	BCR	2.04723925
15	LATS1	1.96700136
16	MKNK1	1.94560187
17	DYRK3	1.88960609
18	VRK1	1.79347676
19	NME1	1.77342368
20	TAF1	1.66524432
21	BLK	1.63898858
22	STK16	1.56727243
23	FRK	1.51825421
24	TRIM28	1.51228175
25	CSNK1G3	1.49670812
26	PBK	1.49102949
27	PLK4	1.47566387
28	CSNK1A1L	1.41131651
29	TESK2	1.39851355
30	PINK1	1.34917334
31	CSNK1G1	1.33971706
32	RPS6KA4	1.33003836
33	EPHA3	1.26415160
34	CSNK1G2	1.19099112
35	TAOK3	1.19096378
36	ERBB3	1.10818529
37	CCNB1	1.10725432
38	ADRBK2	1.09450330
39	ATR	1.08843886
40	BUB1	1.07105286
41	EPHB2	0.96731107
42	EPHA4	0.96178923
43	GRK7	0.95239819
44	OXSR1	0.95127257
45	BMPR1B	0.94487659
46	MAP3K6	0.91273851
47	PLK2	0.90478560
48	PLK1	0.88527651
49	PLK3	0.85884477
50	NEK1	0.82828256
51	DAPK1	0.82512960
52	MAPKAPK5	0.78832490
53	GRK1	0.77339163
54	DAPK2	0.76010053
55	GRK5	0.74488448
56	RPS6KA5	0.73763845
57	MAPK13	0.73139325
58	NEK2	0.72937997
59	CAMKK2	0.72210990
60	PAK6	0.71589284
61	PRKCG	0.70908536
62	MAP2K4	0.65487192
63	DYRK1A	0.65397014
64	PRKCE	0.64727477
65	MKNK2	0.63990317
66	INSRR	0.63325044
67	DYRK1B	0.58229447
68	CSNK1A1	0.58120657
69	AURKB	0.58110500
70	CHEK2	0.57288706
71	IRAK2	0.56049558
72	TNIK	0.54787222
73	CAMK1D	0.53620890
74	TAOK1	0.49119604
75	LIMK1	0.47829366
76	EIF2AK3	0.47095649
77	TLK1	0.45558429
78	AURKA	0.45509662
79	MAP3K5	0.45448698
80	PIM2	0.42025466
81	BRD4	0.41822830
82	CSNK2A1	0.41684220
83	KDR	0.41613699
84	MARK1	0.41435016
85	SIK2	0.40632860
86	NTRK2	0.39745181
87	CSNK2A2	0.38239876
88	IRAK1	0.36114402
89	OBSCN	0.35806945
90	CAMK4	0.35505711
91	KSR1	0.35346346
92	CAMK1	0.34215829
93	CAMK2A	0.33083992
94	WNK4	0.32643508
95	PRKACA	0.31809532
96	CDK3	0.30612692
97	FGFR1	0.30232608
98	ATM	0.29376103
99	ADRBK1	0.28876301
100	PAK3	0.28350946

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.15980309
2	Parkinsons disease_Homo sapiens_hsa05012	2.74910197
3	Mismatch repair_Homo sapiens_hsa03430	2.58649708
4	Homologous recombination_Homo sapiens_hsa03440	2.55095905
5	RNA polymerase_Homo sapiens_hsa03020	2.53573546
6	Ribosome_Homo sapiens_hsa03010	2.49856145
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.38742923
8	Base excision repair_Homo sapiens_hsa03410	2.33364939
9	Proteasome_Homo sapiens_hsa03050	2.32310916
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30045307
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.26685876
12	Nicotine addiction_Homo sapiens_hsa05033	2.15638338
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.06659251
14	Spliceosome_Homo sapiens_hsa03040	2.06481246
15	DNA replication_Homo sapiens_hsa03030	2.06162063
16	Huntingtons disease_Homo sapiens_hsa05016	2.06045094
17	Protein export_Homo sapiens_hsa03060	1.96252002
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.81931060
19	Alzheimers disease_Homo sapiens_hsa05010	1.78576400
20	RNA degradation_Homo sapiens_hsa03018	1.74941803
21	Propanoate metabolism_Homo sapiens_hsa00640	1.72600537
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.62083922
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.59856993
24	Butanoate metabolism_Homo sapiens_hsa00650	1.59543188
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.56225666
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.50791650
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.50635136
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.49671573
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.48924733
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47614161
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.42555398
32	RNA transport_Homo sapiens_hsa03013	1.40545743
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.39267329
34	Basal transcription factors_Homo sapiens_hsa03022	1.31154080
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.29159206
36	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.25817954
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25080663
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19489342
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.19319099
40	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.18659767
41	Sulfur relay system_Homo sapiens_hsa04122	1.15511524
42	Caffeine metabolism_Homo sapiens_hsa00232	1.14816917
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14558464
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10118242
45	Ether lipid metabolism_Homo sapiens_hsa00565	1.08902829
46	Fatty acid elongation_Homo sapiens_hsa00062	1.08862615
47	Peroxisome_Homo sapiens_hsa04146	1.08547681
48	Purine metabolism_Homo sapiens_hsa00230	0.98162215
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.97550259
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96228058
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95557515
52	Regulation of autophagy_Homo sapiens_hsa04140	0.94860306
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93112854
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.88660971
55	One carbon pool by folate_Homo sapiens_hsa00670	0.86642850
56	Glutathione metabolism_Homo sapiens_hsa00480	0.86387257
57	Metabolic pathways_Homo sapiens_hsa01100	0.84290159
58	Fatty acid degradation_Homo sapiens_hsa00071	0.84041171
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83148487
60	Cell cycle_Homo sapiens_hsa04110	0.82788405
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80750778
62	mRNA surveillance pathway_Homo sapiens_hsa03015	0.80485254
63	Taste transduction_Homo sapiens_hsa04742	0.79333236
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.78933242
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77076524
66	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76856081
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.74500405
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73197112
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70236967
70	GABAergic synapse_Homo sapiens_hsa04727	0.69997057
71	Phototransduction_Homo sapiens_hsa04744	0.69745219
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66594524
73	Olfactory transduction_Homo sapiens_hsa04740	0.65841439
74	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.61701612
75	Retinol metabolism_Homo sapiens_hsa00830	0.61608946
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.58500108
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58022067
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.57185161
79	Morphine addiction_Homo sapiens_hsa05032	0.56591576
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55025832
81	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54342651
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54105837
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.54103170
84	Lysine degradation_Homo sapiens_hsa00310	0.46393267
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44153486
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42833634
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42583924
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42273725
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42028024
90	Oocyte meiosis_Homo sapiens_hsa04114	0.42004047
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40933681
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36327264
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.36090624
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35046566
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34568305
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.33188289
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.33078766
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32529066
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31998303
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30042717

CROCCP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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