CRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54474053
2L-phenylalanine catabolic process (GO:0006559)7.54474053
3L-phenylalanine metabolic process (GO:0006558)7.19925200
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.19925200
5regulation of transforming growth factor beta1 production (GO:0032908)7.09765839
6exogenous drug catabolic process (GO:0042738)6.93856478
7aromatic amino acid family catabolic process (GO:0009074)6.89080800
8omega-hydroxylase P450 pathway (GO:0097267)6.66524690
9epoxygenase P450 pathway (GO:0019373)6.55556005
10* acute inflammatory response (GO:0002526)6.47686993
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.40634655
12tryptophan catabolic process (GO:0006569)6.33111072
13indole-containing compound catabolic process (GO:0042436)6.33111072
14indolalkylamine catabolic process (GO:0046218)6.33111072
15positive regulation of heterotypic cell-cell adhesion (GO:0034116)6.29331080
16positive regulation of glomerulus development (GO:0090193)6.10443265
17kynurenine metabolic process (GO:0070189)6.10412568
18tryptophan metabolic process (GO:0006568)5.94883482
19bile acid biosynthetic process (GO:0006699)5.94878090
20chronic inflammatory response (GO:0002544)5.79920110
21negative regulation of fibrinolysis (GO:0051918)5.72074244
22high-density lipoprotein particle remodeling (GO:0034375)5.71434479
23glyoxylate metabolic process (GO:0046487)5.70624199
24urea cycle (GO:0000050)5.64612443
25urea metabolic process (GO:0019627)5.64612443
26negative regulation of inflammatory response to antigenic stimulus (GO:0002862)5.56164061
27complement activation, alternative pathway (GO:0006957)5.55622170
28regulation of fibrinolysis (GO:0051917)5.54224597
29regulation of protein activation cascade (GO:2000257)5.53988558
30protein carboxylation (GO:0018214)5.47869849
31peptidyl-glutamic acid carboxylation (GO:0017187)5.47869849
32alpha-linolenic acid metabolic process (GO:0036109)5.44717763
33* opsonization (GO:0008228)5.35539794
34regulation of humoral immune response (GO:0002920)5.31891628
35sulfur amino acid catabolic process (GO:0000098)5.19242718
36nitrogen cycle metabolic process (GO:0071941)5.18079132
37regulation of complement activation (GO:0030449)5.15110027
38cysteine metabolic process (GO:0006534)5.13993764
39bile acid metabolic process (GO:0008206)5.08952479
40regulation of cholesterol esterification (GO:0010872)5.06398542
41flavonoid metabolic process (GO:0009812)5.01516189
42serine family amino acid catabolic process (GO:0009071)5.00963235
43aromatic amino acid family metabolic process (GO:0009072)4.99875581
44reverse cholesterol transport (GO:0043691)4.98764874
45regulation of triglyceride catabolic process (GO:0010896)4.91864062
46protein-lipid complex remodeling (GO:0034368)4.89148402
47macromolecular complex remodeling (GO:0034367)4.89148402
48plasma lipoprotein particle remodeling (GO:0034369)4.89148402
49pantothenate metabolic process (GO:0015939)4.88644011
50positive regulation of T cell differentiation in thymus (GO:0033089)4.88187608
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84264348
52regulation of apoptotic cell clearance (GO:2000425)4.82410722
53tyrosine metabolic process (GO:0006570)4.80497971
54phospholipid efflux (GO:0033700)4.75766714
55oxidative demethylation (GO:0070989)4.71582075
56homocysteine metabolic process (GO:0050667)4.67288921
57calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.66813365
58acylglycerol homeostasis (GO:0055090)4.66440345
59triglyceride homeostasis (GO:0070328)4.66440345
60negative regulation of sterol transport (GO:0032372)4.61382090
61negative regulation of cholesterol transport (GO:0032375)4.61382090
62alpha-amino acid catabolic process (GO:1901606)4.59611072
63drug metabolic process (GO:0017144)4.58019772
64regulation of cell proliferation involved in kidney development (GO:1901722)4.56181442
65amino-acid betaine metabolic process (GO:0006577)4.50112316
66indolalkylamine metabolic process (GO:0006586)4.49783456
67amine catabolic process (GO:0009310)4.44241330
68cellular biogenic amine catabolic process (GO:0042402)4.44241330
69lysine metabolic process (GO:0006553)4.43125004
70lysine catabolic process (GO:0006554)4.43125004
71plasma lipoprotein particle clearance (GO:0034381)4.40777999
72positive regulation of transforming growth factor beta production (GO:0071636)4.40367948
73bile acid and bile salt transport (GO:0015721)4.39985224
74transepithelial transport (GO:0070633)4.38824879
75coenzyme catabolic process (GO:0009109)4.36487437
76cholesterol efflux (GO:0033344)4.34691227
77imidazole-containing compound metabolic process (GO:0052803)4.31552597
78cellular ketone body metabolic process (GO:0046950)4.29948815
79phenylpropanoid metabolic process (GO:0009698)4.25475634
80negative regulation of coagulation (GO:0050819)4.25347758
81cellular glucuronidation (GO:0052695)4.24779867
82glycine metabolic process (GO:0006544)4.23814337
83benzene-containing compound metabolic process (GO:0042537)4.20623463
84cellular amino acid catabolic process (GO:0009063)4.20292359
85fibrinolysis (GO:0042730)4.11411922
86glutamate metabolic process (GO:0006536)4.11192706
87negative regulation of complement activation (GO:0045916)4.10867893
88low-density lipoprotein particle remodeling (GO:0034374)4.06693024
89plasma lipoprotein particle assembly (GO:0034377)4.06057211
90serine family amino acid metabolic process (GO:0009069)4.02965178
91arginine metabolic process (GO:0006525)4.01117316
92dicarboxylic acid biosynthetic process (GO:0043650)3.99475237
93blood coagulation, intrinsic pathway (GO:0007597)3.95919739
94aldehyde catabolic process (GO:0046185)3.95630836
95drug catabolic process (GO:0042737)3.93978914
96cellular modified amino acid catabolic process (GO:0042219)3.93819799
97ethanol oxidation (GO:0006069)3.91713756
98negative regulation of blood coagulation (GO:0030195)3.90244045
99negative regulation of hemostasis (GO:1900047)3.90244045
100regulation of plasminogen activation (GO:0010755)3.88617213
101negative regulation of lipase activity (GO:0060192)3.87645575
102serine family amino acid biosynthetic process (GO:0009070)3.86824138
103positive regulation of lipoprotein lipase activity (GO:0051006)3.86329020
104positive regulation of triglyceride lipase activity (GO:0061365)3.86329020
105very-low-density lipoprotein particle assembly (GO:0034379)3.85890926
106regulation of glomerulus development (GO:0090192)3.82981990
107cofactor catabolic process (GO:0051187)3.82181437
108regulation of acute inflammatory response (GO:0002673)3.78851006
109cytolysis (GO:0019835)3.78225967
110uronic acid metabolic process (GO:0006063)3.77485452
111glucuronate metabolic process (GO:0019585)3.77485452
112maintenance of gastrointestinal epithelium (GO:0030277)3.77301541
113positive regulation of lipid catabolic process (GO:0050996)3.76525587
114* protein activation cascade (GO:0072376)3.75695158
115regulation of bile acid biosynthetic process (GO:0070857)3.74414552
116phospholipid homeostasis (GO:0055091)3.72637079
117ketone body metabolic process (GO:1902224)3.71632160
118plasma lipoprotein particle organization (GO:0071827)3.71580347
119cholesterol homeostasis (GO:0042632)3.71461752
120killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.70780485
121disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.70780485
122* complement activation, classical pathway (GO:0006958)3.70485959
123* complement activation (GO:0006956)3.69966454
124NAD biosynthetic process (GO:0009435)3.69415809
125heme transport (GO:0015886)3.68063964
126carboxylic acid catabolic process (GO:0046395)3.66716081
127organic acid catabolic process (GO:0016054)3.66716081
128negative regulation of protein activation cascade (GO:2000258)3.66180669
129regulation of cellular extravasation (GO:0002691)3.65913953
130sterol homeostasis (GO:0055092)3.65250321
131polyketide metabolic process (GO:0030638)3.63067134
132doxorubicin metabolic process (GO:0044598)3.63067134
133daunorubicin metabolic process (GO:0044597)3.63067134
134negative regulation of wound healing (GO:0061045)3.62458912
135protein-lipid complex assembly (GO:0065005)3.60820544
136* acute-phase response (GO:0006953)3.60449687
137nicotinamide nucleotide biosynthetic process (GO:0019359)3.59081054
138negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)3.48648345
139regulation of transforming growth factor beta production (GO:0071634)3.35521342
140arginine catabolic process (GO:0006527)3.24178729
141cellular response to ethanol (GO:0071361)3.24067612
142regulation of inflammatory response to antigenic stimulus (GO:0002861)3.22051348
143detection of bacterium (GO:0016045)3.21037075
144aminoglycoside antibiotic metabolic process (GO:0030647)3.20206404
145primary alcohol catabolic process (GO:0034310)3.20042566
146negative regulation of humoral immune response (GO:0002921)3.18940872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.25494808
2* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.17800003
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.03877301
4TP63_17297297_ChIP-ChIP_HaCaT_Human6.69214005
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.42565176
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.27859774
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19566945
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.60958787
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.08403754
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06895419
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.06996881
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03408452
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7786367
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.94477514
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89926619
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79222222
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73172827
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72668361
19TP53_16413492_ChIP-PET_HCT116_Human1.71884637
20HTT_18923047_ChIP-ChIP_STHdh_Human1.66557111
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.59940493
22GBX2_23144817_ChIP-Seq_PC3_Human1.58198889
23GATA1_22025678_ChIP-Seq_K562_Human1.47247359
24HNF4A_19822575_ChIP-Seq_HepG2_Human1.38674666
25CLOCK_20551151_ChIP-Seq_293T_Human1.35863266
26* NFE2_27457419_Chip-Seq_LIVER_Mouse1.33841677
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29781857
28* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27909363
29GATA6_25053715_ChIP-Seq_YYC3_Human1.25020017
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24504396
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24468526
32* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15835432
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15294239
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14303842
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12008032
36* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10797446
37* PHF8_20622853_ChIP-Seq_HELA_Human1.10693759
38FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07524772
39IGF1R_20145208_ChIP-Seq_DFB_Human1.07300190
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.05314053
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.04316504
42* NFYA_21822215_ChIP-Seq_K562_Human1.03855623
43CBP_20019798_ChIP-Seq_JUKART_Human1.03000779
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03000779
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02644500
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02248162
47* HNFA_21074721_ChIP-Seq_CACO-2_Human1.01610403
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01441637
49ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99539703
50POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98756686
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98623976
52PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98374325
53NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97319276
54* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96536741
55* STAT3_18555785_Chip-Seq_ESCs_Mouse0.94788761
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94781772
57CJUN_26792858_Chip-Seq_BT549_Human0.94404453
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93906800
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93545844
60SOX2_19829295_ChIP-Seq_ESCs_Human0.93520112
61NANOG_19829295_ChIP-Seq_ESCs_Human0.93520112
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92648509
63* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92186840
64FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91994220
65* E2F1_18555785_Chip-Seq_ESCs_Mouse0.91670835
66* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88135953
67KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87444706
68ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87189205
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86944384
70* NANOG_18555785_Chip-Seq_ESCs_Mouse0.86090491
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85810285
72SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84129283
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83728983
74* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83408170
75* GATA6_21074721_ChIP-Seq_CACO-2_Human0.82794318
76* P53_22387025_ChIP-Seq_ESCs_Mouse0.82708324
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82483311
78* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81788068
79KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81652248
80* OCT4_18555785_Chip-Seq_ESCs_Mouse0.81497206
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81472988
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79974437
83* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79813196
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79167896
85* ZFX_18555785_Chip-Seq_ESCs_Mouse0.78284820
86GATA4_25053715_ChIP-Seq_YYC3_Human0.76177496
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75314191
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75314191
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75202973
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.71074019
91RARA_24833708_ChIP-Seq_LIVER_Mouse0.70192095
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69390594
93TAF15_26573619_Chip-Seq_HEK293_Human0.67934236
94SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67484631
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67186224
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66637382
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64792165
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.63659052
99* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62736931
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62294752
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.61222440
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61065718
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.60883455
104AR_20517297_ChIP-Seq_VCAP_Human0.58437937
105RARB_24833708_ChIP-Seq_LIVER_Mouse0.58086171
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58069933
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.57732362
108CEBPB_22108803_ChIP-Seq_LS180_Human0.56235085
109STAT1_17558387_ChIP-Seq_HELA_Human0.54346249
110EGR1_19032775_ChIP-ChIP_M12_Human0.54247559
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.52830116
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.52743274
113MYC_19915707_ChIP-ChIP_AK7_Human0.52113369
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51942950
115CBP_21632823_ChIP-Seq_H3396_Human0.51475248
116* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.50882943
117ESET_19884257_ChIP-Seq_ESCs_Mouse0.50478134
118BCAT_22108803_ChIP-Seq_LS180_Human0.48869302
119PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46907774
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46888465
121IRF1_19129219_ChIP-ChIP_H3396_Human0.45981143
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.45941447
123* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45366312
124* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.45224400
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.44785978
126ESR1_21235772_ChIP-Seq_MCF-7_Human0.44576955
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.43551176
128P53_21459846_ChIP-Seq_SAOS-2_Human0.43031784
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.41669868
130TAF2_19829295_ChIP-Seq_ESCs_Human0.41481935
131FOXH1_21741376_ChIP-Seq_EPCs_Human0.40510847
132CDX2_22108803_ChIP-Seq_LS180_Human0.40134908
133* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.40030591
134* CRX_20693478_ChIP-Seq_RETINA_Mouse0.39434660
135* EZH2_27294783_Chip-Seq_NPCs_Mouse0.38751942
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.38006422
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.37846475
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.37836141
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.37769263
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37485713
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.37051647
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.36910756
143STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36805771
144NCOR_22424771_ChIP-Seq_293T_Human0.36689205
145GATA2_19941826_ChIP-Seq_K562_Human0.36439940
146STAT3_1855785_ChIP-Seq_MESCs_Mouse0.36012573
147ZNF263_19887448_ChIP-Seq_K562_Human0.35579252
148* MYC_27129775_Chip-Seq_CORNEA_Mouse0.35458323
149SOX2_20726797_ChIP-Seq_SW620_Human0.35019539
150SPI1_26923725_Chip-Seq_HPCs_Mouse0.34866212
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.34772516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.37213296
2MP0005360_urolithiasis7.51775113
3MP0005085_abnormal_gallbladder_physiolo6.47681892
4MP0005365_abnormal_bile_salt6.23488907
5MP0008875_abnormal_xenobiotic_pharmacok5.11149698
6MP0003806_abnormal_nucleotide_metabolis4.14652212
7MP0010386_abnormal_urinary_bladder3.94721772
8MP0003252_abnormal_bile_duct3.93447974
9MP0003300_gastrointestinal_ulcer3.88664845
10MP0010329_abnormal_lipoprotein_level3.57230778
11MP0009840_abnormal_foam_cell3.23431209
12MP0005083_abnormal_biliary_tract2.99750711
13MP0003195_calcinosis2.88530286
14MP0002163_abnormal_gland_morphology2.86351886
15MP0005332_abnormal_amino_acid2.72224117
16MP0004043_abnormal_pH_regulation2.60480031
17MP0001666_abnormal_nutrient_absorption2.57172187
18MP0003191_abnormal_cellular_cholesterol2.41943140
19MP0000609_abnormal_liver_physiology2.14464688
20MP0004019_abnormal_vitamin_homeostasis2.14140618
21MP0002118_abnormal_lipid_homeostasis2.08592814
22MP0002138_abnormal_hepatobiliary_system2.06063603
23MP0002277_abnormal_respiratory_mucosa2.05575047
24MP0003868_abnormal_feces_composition1.91593137
25MP0005319_abnormal_enzyme/_coenzyme1.81144408
26MP0001873_stomach_inflammation1.78104685
27MP0009697_abnormal_copulation1.78035256
28MP0005379_endocrine/exocrine_gland_phen1.76837087
29MP0001764_abnormal_homeostasis1.68688490
30MP0005584_abnormal_enzyme/coenzyme_acti1.53990472
31MP0003646_muscle_fatigue1.47042744
32MP0003011_delayed_dark_adaptation1.40808121
33MP0002089_abnormal_postnatal_growth/wei1.40132188
34MP0005451_abnormal_body_composition1.39487768
35MP0003656_abnormal_erythrocyte_physiolo1.24911462
36MP0003186_abnormal_redox_activity1.23940385
37MP0009643_abnormal_urine_homeostasis1.21236550
38MP0005647_abnormal_sex_gland1.20120930
39MP0009764_decreased_sensitivity_to1.17195743
40MP0000598_abnormal_liver_morphology1.14214726
41MP0000604_amyloidosis1.09071356
42MP0009763_increased_sensitivity_to1.06342720
43MP0002254_reproductive_system_inflammat1.06336582
44MP0000462_abnormal_digestive_system1.06071965
45MP0010368_abnormal_lymphatic_system0.96794675
46MP0009785_altered_susceptibility_to0.96027275
47MP0005023_abnormal_wound_healing0.95524667
48MP0005636_abnormal_mineral_homeostasis0.95493207
49MP0008469_abnormal_protein_level0.95006307
50MP0003705_abnormal_hypodermis_morpholog0.94048132
51MP0000538_abnormal_urinary_bladder0.91318330
52MP0009642_abnormal_blood_homeostasis0.88610307
53MP0002876_abnormal_thyroid_physiology0.87905335
54MP0005408_hypopigmentation0.85942698
55MP0005670_abnormal_white_adipose0.85804438
56MP0005084_abnormal_gallbladder_morpholo0.84127025
57MP0004233_abnormal_muscle_weight0.83374970
58MP0001663_abnormal_digestive_system0.81325831
59MP0009765_abnormal_xenobiotic_induced0.81024047
60MP0001664_abnormal_digestion0.79575756
61MP0000613_abnormal_salivary_gland0.78765642
62MP0005376_homeostasis/metabolism_phenot0.78126051
63MP0002078_abnormal_glucose_homeostasis0.75283483
64MP0006036_abnormal_mitochondrial_physio0.75274451
65MP0003690_abnormal_glial_cell0.73900900
66MP0005220_abnormal_exocrine_pancreas0.73492625
67MP0005410_abnormal_fertilization0.72310893
68MP0005334_abnormal_fat_pad0.69202349
69MP0002971_abnormal_brown_adipose0.68771842
70MP0005535_abnormal_body_temperature0.66901219
71MP0001661_extended_life_span0.66566846
72MP0009278_abnormal_bone_marrow0.66488706
73MP0001545_abnormal_hematopoietic_system0.66061984
74MP0005397_hematopoietic_system_phenotyp0.66061984
75MP0009053_abnormal_anal_canal0.62255288
76MP0005464_abnormal_platelet_physiology0.61529690
77MP0010234_abnormal_vibrissa_follicle0.59957867
78MP0000639_abnormal_adrenal_gland0.59666839
79MP0005266_abnormal_metabolism0.58863518
80MP0002282_abnormal_trachea_morphology0.58691850
81MP0001944_abnormal_pancreas_morphology0.58335077
82MP0003943_abnormal_hepatobiliary_system0.57854209
83MP0003283_abnormal_digestive_organ0.57852216
84MP0004142_abnormal_muscle_tone0.57635495
85MP0004130_abnormal_muscle_cell0.57472274
86MP0003724_increased_susceptibility_to0.55642785
87MP0001756_abnormal_urination0.55145189
88MP0003329_amyloid_beta_deposits0.54615210
89MP0005381_digestive/alimentary_phenotyp0.54249631
90MP0005448_abnormal_energy_balance0.53861150
91MP0005025_abnormal_response_to0.52591997
92MP0010155_abnormal_intestine_physiology0.51332637
93MP0005395_other_phenotype0.51212285
94MP0003436_decreased_susceptibility_to0.51031316
95MP0002249_abnormal_larynx_morphology0.50744010
96MP0006035_abnormal_mitochondrial_morpho0.50649036
97MP0002928_abnormal_bile_duct0.49950212
98MP0006054_spinal_hemorrhage0.47767150
99MP0002822_catalepsy0.47643648
100MP0003718_maternal_effect0.47573284
101MP0004782_abnormal_surfactant_physiolog0.47191905
102MP0005171_absent_coat_pigmentation0.46668591
103MP0008874_decreased_physiological_sensi0.46175282
104MP0002136_abnormal_kidney_physiology0.45241724
105MP0003638_abnormal_response/metabolism_0.45045780
106MP0000343_altered_response_to0.44821978
107MP0003866_abnormal_defecation0.44242059
108MP0004381_abnormal_hair_follicle0.43777441
109MP0005595_abnormal_vascular_smooth0.43082109
110MP0008873_increased_physiological_sensi0.42789492
111MP0003075_altered_response_to0.42260032
112MP0005166_decreased_susceptibility_to0.42068934
113MP0003953_abnormal_hormone_level0.40100904
114MP0005248_abnormal_Harderian_gland0.39362052
115MP0001270_distended_abdomen0.39192330
116MP0006082_CNS_inflammation0.38030937
117MP0001915_intracranial_hemorrhage0.37590165
118MP0000579_abnormal_nail_morphology0.37058953
119MP0008872_abnormal_physiological_respon0.36296996
120MP0005387_immune_system_phenotype0.35852493
121MP0001790_abnormal_immune_system0.35852493
122MP0000477_abnormal_intestine_morphology0.35091119
123MP0002132_abnormal_respiratory_system0.33843160
124MP0002837_dystrophic_cardiac_calcinosis0.33773831
125MP0001853_heart_inflammation0.33507206
126MP0004883_abnormal_blood_vessel0.32862338
127MP0001881_abnormal_mammary_gland0.32845798
128MP0000249_abnormal_blood_vessel0.32540921
129MP0001845_abnormal_inflammatory_respons0.32516017
130MP0002168_other_aberrant_phenotype0.31768752
131MP0009115_abnormal_fat_cell0.31681481
132MP0001243_abnormal_dermal_layer0.29522034
133MP0009384_cardiac_valve_regurgitation0.29428182
134MP0000230_abnormal_systemic_arterial0.29273590
135MP0009672_abnormal_birth_weight0.29221120
136MP0005666_abnormal_adipose_tissue0.28605727
137MP0005164_abnormal_response_to0.27439301
138MP0002970_abnormal_white_adipose0.25714371
139MP0002090_abnormal_vision0.22798375
140MP0000427_abnormal_hair_cycle0.22706092
141MP0002796_impaired_skin_barrier0.22625650

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.45022295
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.38449163
3Intrahepatic cholestasis (HP:0001406)7.33601098
4Prolonged partial thromboplastin time (HP:0003645)6.83545149
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.67794678
6Hypobetalipoproteinemia (HP:0003563)6.39744354
7Xanthomatosis (HP:0000991)6.21337409
8Complement deficiency (HP:0004431)5.71598485
9Ileus (HP:0002595)5.71455462
10Hyperlipoproteinemia (HP:0010980)5.64908677
11Rectal prolapse (HP:0002035)5.50513348
12Joint hemorrhage (HP:0005261)5.05928539
13Hypolipoproteinemia (HP:0010981)4.79400113
14Abnormality of the common coagulation pathway (HP:0010990)4.71122004
15Hyperammonemia (HP:0001987)4.51971237
16Epidermoid cyst (HP:0200040)4.49561973
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.40447186
18Hyperglycinemia (HP:0002154)4.35957073
19Abnormality of methionine metabolism (HP:0010901)4.28371318
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.21263788
21Hypoalphalipoproteinemia (HP:0003233)4.20682510
22Fat malabsorption (HP:0002630)4.19113353
23Abnormality of complement system (HP:0005339)4.18457970
24Ketosis (HP:0001946)4.15898314
25Exocrine pancreatic insufficiency (HP:0001738)4.10865419
26Azoospermia (HP:0000027)4.10669610
27Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09118944
28Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08712763
29Abnormality of pyrimidine metabolism (HP:0004353)3.91097991
30Back pain (HP:0003418)3.90655428
31Conjugated hyperbilirubinemia (HP:0002908)3.90489764
32Male infertility (HP:0003251)3.87477653
33Abnormality of the intrinsic pathway (HP:0010989)3.86127984
34Hypoglycemic coma (HP:0001325)3.84850906
35Abnormality of glycine metabolism (HP:0010895)3.77208335
36Abnormality of serine family amino acid metabolism (HP:0010894)3.77208335
37Hyperglycinuria (HP:0003108)3.75837141
38Hypercholesterolemia (HP:0003124)3.58107050
39Abnormality of the right ventricle (HP:0001707)3.47331191
40Spontaneous abortion (HP:0005268)3.39922383
41Hyperbilirubinemia (HP:0002904)3.32189943
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.25830515
43Abnormality of fatty-acid metabolism (HP:0004359)3.23675943
44Steatorrhea (HP:0002570)3.21819954
45Abnormality of nucleobase metabolism (HP:0010932)3.05566111
46Abnormal spermatogenesis (HP:0008669)3.05220180
47Hypochromic microcytic anemia (HP:0004840)3.04518868
48Abnormality of serum amino acid levels (HP:0003112)3.02946119
49Delayed CNS myelination (HP:0002188)3.00266631
50Myocardial infarction (HP:0001658)2.98772296
51Systemic lupus erythematosus (HP:0002725)2.97034141
52Hepatocellular carcinoma (HP:0001402)2.93516925
53Ketoacidosis (HP:0001993)2.92532741
54Joint swelling (HP:0001386)2.78053842
55Skin nodule (HP:0200036)2.72838576
56Metabolic acidosis (HP:0001942)2.71933093
57Arthropathy (HP:0003040)2.67279731
58Renal tubular acidosis (HP:0001947)2.65726682
59Recurrent gram-negative bacterial infections (HP:0005420)2.65724329
60Glomerulonephritis (HP:0000099)2.65069885
61Vascular calcification (HP:0004934)2.63717752
62Abnormality of purine metabolism (HP:0004352)2.62800171
63Hypoglycemic seizures (HP:0002173)2.59673261
64Lethargy (HP:0001254)2.55193587
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49803236
66Dicarboxylic aciduria (HP:0003215)2.49803236
67Gingival bleeding (HP:0000225)2.49757384
68Mitral stenosis (HP:0001718)2.49360608
69Amyloidosis (HP:0011034)2.48118164
70Acanthocytosis (HP:0001927)2.47045255
71Abnormality of chloride homeostasis (HP:0011422)2.46675343
72Abnormal gallbladder morphology (HP:0012437)2.42413457
73Goiter (HP:0000853)2.38644423
74Cerebral edema (HP:0002181)2.37211895
75Cholelithiasis (HP:0001081)2.35558946
76Cardiovascular calcification (HP:0011915)2.32888027
77Irritability (HP:0000737)2.31608845
78Spastic diplegia (HP:0001264)2.31143672
79Neonatal onset (HP:0003623)2.29324545
80Gout (HP:0001997)2.28329755
81Abnormal gallbladder physiology (HP:0012438)2.26663022
82Cholecystitis (HP:0001082)2.26663022
83Abnormal pancreas size (HP:0012094)2.26633823
84Menorrhagia (HP:0000132)2.24638208
85Potter facies (HP:0002009)2.23096704
86Facial shape deformation (HP:0011334)2.23096704
87Thrombophlebitis (HP:0004418)2.21016352
88Abnormality of the Achilles tendon (HP:0005109)2.20489753
89Enlarged kidneys (HP:0000105)2.17091203
90Esophageal varix (HP:0002040)2.16139675
91Pancreatitis (HP:0001733)2.15744232
92Malnutrition (HP:0004395)2.12212392
93Late onset (HP:0003584)2.10903658
94Sensorimotor neuropathy (HP:0007141)2.10800177
95Opisthotonus (HP:0002179)2.10020452
96Hyperinsulinemic hypoglycemia (HP:0000825)2.07775817
97Brushfield spots (HP:0001088)2.06267678
98Abnormal biliary tract morphology (HP:0012440)2.06118348
99Vomiting (HP:0002013)2.02495024
100Generalized aminoaciduria (HP:0002909)2.01809588
101Abnormality of iron homeostasis (HP:0011031)2.00489170
102Poikilocytosis (HP:0004447)1.98300153
103Renal cortical cysts (HP:0000803)1.97912764
104Abnormality of the gallbladder (HP:0005264)1.97885684
105Abnormality of alkaline phosphatase activity (HP:0004379)1.97417517
106Hemorrhage of the eye (HP:0011885)1.97413803
107Hypophosphatemic rickets (HP:0004912)1.95915324
108Abnormality of transition element cation homeostasis (HP:0011030)1.94816096
109Rickets (HP:0002748)1.94670180
110Infertility (HP:0000789)1.90869056
111Purpura (HP:0000979)1.90197855
112Nephritis (HP:0000123)1.85915805
113Spinal muscular atrophy (HP:0007269)1.85716377
114Abnormality of proline metabolism (HP:0010907)1.83006236
115Hydroxyprolinuria (HP:0003080)1.83006236
116Renal tubular dysfunction (HP:0000124)1.82857402
117Status epilepticus (HP:0002133)1.82762479
118Abnormal enzyme/coenzyme activity (HP:0012379)1.81707966
119Elevated hepatic transaminases (HP:0002910)1.81652715
120Elevated alkaline phosphatase (HP:0003155)1.80814066
121Alkalosis (HP:0001948)1.80192529
122Hyperglycemia (HP:0003074)1.77293742
123Glycosuria (HP:0003076)1.76233334
124Abnormality of urine glucose concentration (HP:0011016)1.76233334
125Abnormality of vitamin metabolism (HP:0100508)1.74652722
126Pulmonary embolism (HP:0002204)1.72383203
127Recurrent pneumonia (HP:0006532)1.66976283
128Hyperuricemia (HP:0002149)1.65688947
129Increased purine levels (HP:0004368)1.65688947
130Abnormal delivery (HP:0001787)1.64062128
131Abnormality of male internal genitalia (HP:0000022)1.62971254
132Increased serum ferritin (HP:0003281)1.61779226
133Gastrointestinal dysmotility (HP:0002579)1.61563905
134Abnormal cartilage morphology (HP:0002763)1.59450997
135Increased serum pyruvate (HP:0003542)1.56920445
136Abnormality of the anterior horn cell (HP:0006802)1.53846980
137Degeneration of anterior horn cells (HP:0002398)1.53846980
138Follicular hyperkeratosis (HP:0007502)1.51759479
139Infantile muscular hypotonia (HP:0008947)1.48527049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.93602001
2FGFR44.59522350
3ERN14.40654579
4SIK14.25150582
5INSRR3.44936113
6TAOK33.35702966
7PRKG23.07741276
8ERBB43.05488739
9ZAK2.53599221
10MAP2K42.46748618
11LMTK214.1454940
12MST1R1.99581082
13MAP3K21.96336646
14PIK3CG1.94723992
15MAPK111.87722165
16TYK21.75834669
17FLT31.75282345
18STK391.75125586
19DAPK21.70858441
20LATS11.57398801
21FRK1.50216325
22PKN21.49754213
23NEK91.48782167
24MAP3K141.44925576
25ABL21.39361795
26BMPR1B1.36667634
27NLK1.36605934
28OXSR11.35498144
29PTK61.33036910
30ARAF1.24752701
31JAK21.23204115
32FGFR21.22491153
33JAK11.14611593
34TBK11.14611343
35PINK11.13599474
36KDR1.11105326
37PRKAA21.11007229
38TRIB31.09569282
39MAP2K31.08764665
40STK38L1.05452811
41ERBB21.03083087
42MAP3K71.03024056
43EPHA31.02758404
44MAP3K121.00957212
45MAPK151.00909622
46ICK1.00460101
47IRAK31.00082441
48MAPK40.95775700
49GRK60.92350577
50PRKCZ0.91834021
51ROCK10.90662629
52TIE10.86690305
53EPHB10.86222796
54MAPK120.84957820
55PASK0.80467472
56CAMK2G0.80201415
57MAP2K60.79567746
58PNCK0.79175182
59MAP3K30.77560410
60PRKACG0.77395617
61MAPK70.72835424
62TNIK0.72806614
63CSK0.72097094
64IKBKE0.70470166
65PKN10.70049996
66SGK30.69702609
67MET0.68847595
68MYLK0.66835595
69SGK20.66672786
70MAP3K110.65794531
71EPHA40.65454287
72CAMK1D0.65026369
73GRK10.64984382
74GSK3A0.64052014
75MAP3K60.64045897
76TGFBR20.63545364
77CDK60.62727221
78FGFR30.60607915
79DYRK1B0.59455322
80PRKAA10.59254354
81FER0.57577069
82TAOK20.55089637
83PIK3CA0.55009037
84CSF1R0.54180798
85MAP3K100.52834532
86PRKCQ0.52280205
87MAP3K50.52266954
88IRAK10.50858871
89PBK0.49814107
90IGF1R0.49796253
91MARK30.48960590
92PRKCG0.47926517
93VRK20.46567699
94PRKG10.44766206
95SGK4940.43211169
96SGK2230.43211169
97PDPK10.42804060
98IRAK20.41513469
99STK380.41330520
100PTK20.41036276
101AKT30.39864812
102FGFR10.39798364
103MAP3K130.38726649
104CSNK1G10.37956038
105TESK20.37602497
106MAP2K10.37336933
107RIPK10.36496013
108CAMK40.36482204
109MAP3K90.35772995
110NTRK30.34992559
111EGFR0.34910607
112BRAF0.34589603
113MELK0.32170701
114PRKCE0.31820416
115PRKCA0.29628515
116CAMK1G0.29015604
117MAP3K10.28288218
118SIK30.26872093
119TTK0.26714527
120AKT20.26173655
121NME10.25938952
122RET0.25774519
123CDK40.25488740
124CHUK0.25337757
125SCYL20.25179263
126ADRBK20.24879217
127IKBKB0.24792475
128KIT0.24682616
129BMX0.24242480
130PDK10.23548115
131ABL10.23519855
132DAPK10.22194794
133MAPK30.21860078
134PRKACB0.19599793
135PRKACA0.19444689
136STK40.19200301
137ACVR1B0.15832334
138MAPKAPK30.15245545
139EIF2AK10.15035129
140PIM20.13842092
141TAF10.12918841
142BMPR20.12910638
143STK110.11361491
144CAMKK20.10391844
145PRKCB0.08523262
146CSNK2A10.08153389
147CDK90.06292912
148SRC0.05950540
149SGK10.05926562

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.59251763
2Nitrogen metabolism_Homo sapiens_hsa009103.43988561
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37875311
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33040805
5Arginine biosynthesis_Homo sapiens_hsa002203.03906894
6Complement and coagulation cascades_Homo sapiens_hsa046102.93704587
7Tryptophan metabolism_Homo sapiens_hsa003802.71083994
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66543168
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53988200
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51496476
11Fatty acid degradation_Homo sapiens_hsa000712.41751766
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33788226
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24933354
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22521662
15Peroxisome_Homo sapiens_hsa041462.09856437
16Butanoate metabolism_Homo sapiens_hsa006502.08780139
17Chemical carcinogenesis_Homo sapiens_hsa052042.01726599
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99225480
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.98976597
20Histidine metabolism_Homo sapiens_hsa003401.95448534
21Staphylococcus aureus infection_Homo sapiens_hsa051501.91029524
22Propanoate metabolism_Homo sapiens_hsa006401.87677919
23PPAR signaling pathway_Homo sapiens_hsa033201.84011803
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.76229936
25Fatty acid metabolism_Homo sapiens_hsa012121.74887470
26Caffeine metabolism_Homo sapiens_hsa002321.74661491
27Retinol metabolism_Homo sapiens_hsa008301.73864472
28beta-Alanine metabolism_Homo sapiens_hsa004101.72804000
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71438835
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70254207
31Phenylalanine metabolism_Homo sapiens_hsa003601.59671682
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55163877
33Selenocompound metabolism_Homo sapiens_hsa004501.54509987
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54173010
35Bile secretion_Homo sapiens_hsa049761.47529933
36Tyrosine metabolism_Homo sapiens_hsa003501.46673548
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39404559
38Sulfur metabolism_Homo sapiens_hsa009201.36594290
39Fatty acid elongation_Homo sapiens_hsa000621.32517353
40Pyruvate metabolism_Homo sapiens_hsa006201.28959604
41Starch and sucrose metabolism_Homo sapiens_hsa005001.28867414
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.27687057
43ABC transporters_Homo sapiens_hsa020101.24069403
44Steroid biosynthesis_Homo sapiens_hsa001001.23412615
45Folate biosynthesis_Homo sapiens_hsa007901.23359434
46Fat digestion and absorption_Homo sapiens_hsa049751.15226834
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12009856
48Biosynthesis of amino acids_Homo sapiens_hsa012301.11800746
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.08976794
50Carbon metabolism_Homo sapiens_hsa012001.03803512
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02905028
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96888257
53Arginine and proline metabolism_Homo sapiens_hsa003300.96454124
54Vitamin B6 metabolism_Homo sapiens_hsa007500.96113293
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.93537443
56Vitamin digestion and absorption_Homo sapiens_hsa049770.93454723
57Sulfur relay system_Homo sapiens_hsa041220.89769974
58Lysine degradation_Homo sapiens_hsa003100.78423002
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77758081
60One carbon pool by folate_Homo sapiens_hsa006700.73992948
61Pancreatic secretion_Homo sapiens_hsa049720.69501505
62Glutathione metabolism_Homo sapiens_hsa004800.67309128
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63469887
64Glycerolipid metabolism_Homo sapiens_hsa005610.63253577
65Pentose phosphate pathway_Homo sapiens_hsa000300.51260155
66Fatty acid biosynthesis_Homo sapiens_hsa000610.50132956
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48869975
68Metabolic pathways_Homo sapiens_hsa011000.46083364
69Prion diseases_Homo sapiens_hsa050200.41499103
70Mineral absorption_Homo sapiens_hsa049780.40389737
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35770133
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.32895773
73Vibrio cholerae infection_Homo sapiens_hsa051100.32876997
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30269616
75Linoleic acid metabolism_Homo sapiens_hsa005910.28325969
76Malaria_Homo sapiens_hsa051440.26805405
77Galactose metabolism_Homo sapiens_hsa000520.23309217
78Tight junction_Homo sapiens_hsa045300.23274777
79Fructose and mannose metabolism_Homo sapiens_hsa000510.21243526
80Insulin resistance_Homo sapiens_hsa049310.20091826
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19509932
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.18403621
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.16582021
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16558440
85Sphingolipid metabolism_Homo sapiens_hsa006000.15255625
86TNF signaling pathway_Homo sapiens_hsa046680.08360047
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.07884933
88Glucagon signaling pathway_Homo sapiens_hsa049220.07382639
89Protein digestion and absorption_Homo sapiens_hsa049740.06955505
90Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2509243
91Amoebiasis_Homo sapiens_hsa05146-0.2262581
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2208408
93Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2178801
94Pertussis_Homo sapiens_hsa05133-0.2073926
95Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2007012
96Renin-angiotensin system_Homo sapiens_hsa04614-0.2002213
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1939142
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1926956
99Ether lipid metabolism_Homo sapiens_hsa00565-0.1915479
100Hepatitis C_Homo sapiens_hsa05160-0.1532134
101Insulin signaling pathway_Homo sapiens_hsa04910-0.1417656
102Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1385183
103Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1379325
104Regulation of autophagy_Homo sapiens_hsa04140-0.0999537
105Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0937024
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0790185
107African trypanosomiasis_Homo sapiens_hsa05143-0.0771722
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0653544
109ECM-receptor interaction_Homo sapiens_hsa04512-0.0622102
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0590208
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0502523
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0441153
113Other glycan degradation_Homo sapiens_hsa00511-0.0333847
114AMPK signaling pathway_Homo sapiens_hsa04152-0.0239165
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0116193
116Serotonergic synapse_Homo sapiens_hsa04726-0.0069645

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