CRTAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)6.05719902
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51456997
3neuron cell-cell adhesion (GO:0007158)5.39266107
4synaptic vesicle exocytosis (GO:0016079)5.18261977
5synaptic vesicle maturation (GO:0016188)5.16489231
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12091817
7vocalization behavior (GO:0071625)5.08567336
8chemical homeostasis within a tissue (GO:0048875)4.94310109
9protein localization to synapse (GO:0035418)4.92783416
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92016330
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87624373
12glutamate secretion (GO:0014047)4.74799596
13regulation of synaptic vesicle exocytosis (GO:2000300)4.57902849
14locomotory exploration behavior (GO:0035641)4.49918938
15neuronal action potential propagation (GO:0019227)4.49349527
16regulation of glutamate receptor signaling pathway (GO:1900449)4.49049684
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.45977567
18neuron recognition (GO:0008038)4.20031464
19glutamate receptor signaling pathway (GO:0007215)4.11845411
20exploration behavior (GO:0035640)4.11498697
21presynaptic membrane assembly (GO:0097105)4.09693244
22regulation of neuronal synaptic plasticity (GO:0048168)4.07139395
23neurotransmitter secretion (GO:0007269)3.99924682
24regulation of synaptic vesicle transport (GO:1902803)3.99431733
25layer formation in cerebral cortex (GO:0021819)3.97204655
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.96395172
27presynaptic membrane organization (GO:0097090)3.92557193
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91765016
29gamma-aminobutyric acid signaling pathway (GO:0007214)3.89029957
30synaptic transmission, glutamatergic (GO:0035249)3.83905177
31peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.82688927
32gamma-aminobutyric acid transport (GO:0015812)3.80499845
33amino acid import (GO:0043090)3.78770545
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77412369
35potassium ion homeostasis (GO:0055075)3.76797081
36dendritic spine morphogenesis (GO:0060997)3.75499642
37neuron-neuron synaptic transmission (GO:0007270)3.73934433
38axonal fasciculation (GO:0007413)3.69361030
39central nervous system myelination (GO:0022010)3.68753732
40axon ensheathment in central nervous system (GO:0032291)3.68753732
41transmission of nerve impulse (GO:0019226)3.59759211
42positive regulation of membrane potential (GO:0045838)3.56624848
43neurotransmitter-gated ion channel clustering (GO:0072578)3.56311160
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56225453
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.54784049
46proline transport (GO:0015824)3.53504054
47regulation of dendritic spine morphogenesis (GO:0061001)3.52810649
48melanin biosynthetic process (GO:0042438)3.52163085
49postsynaptic membrane organization (GO:0001941)3.51264860
50neurotransmitter transport (GO:0006836)3.43463049
51positive regulation of synapse maturation (GO:0090129)3.42788412
52synaptic vesicle endocytosis (GO:0048488)3.42437609
53regulation of postsynaptic membrane potential (GO:0060078)3.37814354
54long-term memory (GO:0007616)3.37090301
55cellular response to nitric oxide (GO:0071732)3.35884739
56establishment of mitochondrion localization (GO:0051654)3.33543302
57regulation of synapse structural plasticity (GO:0051823)3.33515688
58chondroitin sulfate catabolic process (GO:0030207)3.33420722
59negative regulation of neurotransmitter transport (GO:0051589)3.31075593
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29381517
61regulation of synaptic plasticity (GO:0048167)3.29377973
62regulation of vesicle fusion (GO:0031338)3.28369310
63cellular potassium ion homeostasis (GO:0030007)3.24561833
64long-term synaptic potentiation (GO:0060291)3.24374904
65mating behavior (GO:0007617)3.23584691
66melanin metabolic process (GO:0006582)3.23298247
67positive regulation of dendritic spine development (GO:0060999)3.18376762
68regulation of neurotransmitter secretion (GO:0046928)3.18060114
69regulation of dendritic spine development (GO:0060998)3.16232807
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14618486
71long-chain fatty acid biosynthetic process (GO:0042759)3.12270717
72negative regulation of catenin import into nucleus (GO:0035414)3.11509367
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11292375
74regulation of neurotransmitter levels (GO:0001505)3.10995592
75neuronal ion channel clustering (GO:0045161)3.09541353
76adult walking behavior (GO:0007628)3.09073994
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08809570
78cellular sodium ion homeostasis (GO:0006883)3.07551579
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06968680
80neuromuscular process controlling posture (GO:0050884)3.05966561
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.05457784
82regulation of ARF protein signal transduction (GO:0032012)3.05347628
83one-carbon compound transport (GO:0019755)3.04816857
84dendrite morphogenesis (GO:0048813)3.03954326
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.02915496
86regulation of glutamate secretion (GO:0014048)3.02129392
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99873129
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97668254
89synapse assembly (GO:0007416)2.97286022
90regulation of voltage-gated calcium channel activity (GO:1901385)2.96716428
91learning (GO:0007612)2.96188557
92membrane depolarization (GO:0051899)2.95193078
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94987783
94membrane hyperpolarization (GO:0060081)2.94290365
95organelle transport along microtubule (GO:0072384)2.91311215
96dermatan sulfate biosynthetic process (GO:0030208)2.91179765
97behavioral fear response (GO:0001662)2.90808306
98behavioral defense response (GO:0002209)2.90808306
99positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90664780
100cell migration in hindbrain (GO:0021535)2.89684121
101positive regulation of dendritic spine morphogenesis (GO:0061003)2.89676885
102regulation of neurotransmitter transport (GO:0051588)2.89249826
103glial cell proliferation (GO:0014009)2.89054328
104positive regulation of neurotransmitter secretion (GO:0001956)2.85721415
105regulation of synaptic transmission (GO:0050804)2.85539390
106secondary metabolite biosynthetic process (GO:0044550)2.85436358
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84539308
108potassium ion import (GO:0010107)2.83878611
109dendritic spine organization (GO:0097061)2.82390584
110glycine transport (GO:0015816)2.82080544
111synapse organization (GO:0050808)2.81788287
112synaptic transmission (GO:0007268)2.81120418
113regulation of synapse maturation (GO:0090128)2.81091737
114neuromuscular process controlling balance (GO:0050885)2.80613586
115innervation (GO:0060384)2.80201695
116cerebellar granule cell differentiation (GO:0021707)2.78328231
117L-amino acid import (GO:0043092)2.78244142
118sodium ion export (GO:0071436)2.78097629
119negative regulation of amino acid transport (GO:0051956)2.77981149
120cerebellar Purkinje cell differentiation (GO:0021702)2.77812105
121G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.77630185
122dermatan sulfate metabolic process (GO:0030205)2.74916291
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.69950618
124regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.67515235
125positive regulation of neurotransmitter transport (GO:0051590)2.66701336
126cell communication by electrical coupling (GO:0010644)2.66105955
127cellular response to reactive nitrogen species (GO:1902170)2.66050318
128cerebellar Purkinje cell layer development (GO:0021680)2.65462047
129auditory behavior (GO:0031223)2.62794948
130positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60000614
131neurotransmitter uptake (GO:0001504)2.57748511
132regulation of beta-amyloid formation (GO:1902003)2.57572942
133neuromuscular process (GO:0050905)2.46108501
134myelination in peripheral nervous system (GO:0022011)2.43111123
135peripheral nervous system axon ensheathment (GO:0032292)2.43111123
136sodium ion homeostasis (GO:0055078)2.42451282
137keratan sulfate catabolic process (GO:0042340)2.40152135
138myelin maintenance (GO:0043217)2.37434313
139negative regulation of dendrite morphogenesis (GO:0050774)2.37324178
140acidic amino acid transport (GO:0015800)2.36528465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84157329
2GBX2_23144817_ChIP-Seq_PC3_Human3.72064463
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25491438
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18139894
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10593867
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79146548
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79146548
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68171700
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67551379
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.64173980
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61252495
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60469361
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.59541103
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58465778
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.57842001
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53249292
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.48288218
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.38234058
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34183783
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.31964428
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.29413601
22DROSHA_22980978_ChIP-Seq_HELA_Human2.21451594
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.21070268
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12270875
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.11643053
26TAF15_26573619_Chip-Seq_HEK293_Human2.06336310
27AR_21572438_ChIP-Seq_LNCaP_Human1.99030717
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97987109
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90060623
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89502229
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88358080
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83357196
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.74231951
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71121648
35KDM2B_26808549_Chip-Seq_K562_Human1.65924232
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62868619
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61266140
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.55147241
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54314417
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.53536826
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52985863
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52773993
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50533927
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49147919
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47956206
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47542861
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46644084
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.45739895
49P300_19829295_ChIP-Seq_ESCs_Human1.45000237
50* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43508241
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.42950444
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.40769271
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39184375
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39012871
55ZNF274_21170338_ChIP-Seq_K562_Hela1.38204318
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.36806110
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36062418
58IGF1R_20145208_ChIP-Seq_DFB_Human1.30062622
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29619846
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29121759
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26989348
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26957821
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26773466
64* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25204008
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24795569
66* CTCF_27219007_Chip-Seq_Bcells_Human1.24752434
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.24590504
68RNF2_27304074_Chip-Seq_NSC_Mouse1.22577244
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21761151
70LXR_22292898_ChIP-Seq_THP-1_Human1.21479509
71FUS_26573619_Chip-Seq_HEK293_Human1.20913288
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20343435
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20320297
74AR_25329375_ChIP-Seq_VCAP_Human1.19901155
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.19614503
76STAT3_23295773_ChIP-Seq_U87_Human1.18851392
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18719798
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18206320
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18074602
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17955203
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17071202
82* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14770888
83* RING1B_27294783_Chip-Seq_NPCs_Mouse1.14584831
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12935020
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12281359
86* TET1_21490601_ChIP-Seq_MESCs_Mouse1.11425163
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09638020
88ER_23166858_ChIP-Seq_MCF-7_Human1.09116441
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.09031154
90VDR_22108803_ChIP-Seq_LS180_Human1.08661165
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07183467
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06429605
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.05240291
94TCF4_23295773_ChIP-Seq_U87_Human1.04591005
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04582945
96AR_19668381_ChIP-Seq_PC3_Human1.03668283
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01937683
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01847718
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.01629253
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.01545132
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00113070
102AHR_22903824_ChIP-Seq_MCF-7_Human1.00105101
103NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99102139
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98405089
105JUN_21703547_ChIP-Seq_K562_Human0.95204805
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95146368
107RUNX2_22187159_ChIP-Seq_PCA_Human0.94568179
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.93884393
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93645410
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92428789
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92414575
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92351786
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91125447
114TP53_16413492_ChIP-PET_HCT116_Human0.90646676
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90606883
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89829834
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88976668
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88852622
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.88667988
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.88482456
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.88202247
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87829243
123TBX20_22080862_ChIP-Seq_HEART_Mouse0.87376170
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.87376170
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86867061
126SMC4_20622854_ChIP-Seq_HELA_Human0.86556437
127TP53_18474530_ChIP-ChIP_U2OS_Human0.85924579
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.85881153
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85715743
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85715743
131* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82975484
132SMAD4_21741376_ChIP-Seq_EPCs_Human0.81987765
133CLOCK_20551151_ChIP-Seq_293T_Human0.81610722
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81348324
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80974475
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.80851604
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80644202
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79544226
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78385979
140KLF4_19829295_ChIP-Seq_ESCs_Human0.77854129
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76353975
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73822382
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.73117333
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.72061375
145MYC_27129775_Chip-Seq_CORNEA_Mouse0.71562532
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.71402582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.96573405
2MP0003880_abnormal_central_pattern5.34239971
3MP0003635_abnormal_synaptic_transmissio3.96546799
4MP0004270_analgesia3.74320939
5MP0009745_abnormal_behavioral_response3.34480732
6MP0002064_seizures3.20636889
7MP0002063_abnormal_learning/memory/cond3.13673083
8MP0009046_muscle_twitch2.96019016
9MP0004782_abnormal_surfactant_physiolog2.81731924
10MP0001958_emphysema2.80710738
11MP0002272_abnormal_nervous_system2.77373938
12MP0001968_abnormal_touch/_nociception2.73037318
13MP0002572_abnormal_emotion/affect_behav2.69517112
14MP0005423_abnormal_somatic_nervous2.69091091
15MP0001486_abnormal_startle_reflex2.66897169
16MP0002734_abnormal_mechanical_nocicepti2.61233925
17MP0003329_amyloid_beta_deposits2.55963409
18MP0002735_abnormal_chemical_nociception2.51803914
19MP0005503_abnormal_tendon_morphology2.33297257
20MP0001501_abnormal_sleep_pattern2.25716484
21MP0001440_abnormal_grooming_behavior2.17138068
22MP0000778_abnormal_nervous_system2.15322695
23MP0002733_abnormal_thermal_nociception2.13656201
24MP0002736_abnormal_nociception_after2.13418633
25MP0003136_yellow_coat_color2.03436941
26MP0006276_abnormal_autonomic_nervous2.02823397
27MP0001970_abnormal_pain_threshold2.00063537
28MP0002067_abnormal_sensory_capabilities1.95414953
29MP0002822_catalepsy1.92377788
30MP0002184_abnormal_innervation1.92324327
31MP0003011_delayed_dark_adaptation1.88152693
32MP0004142_abnormal_muscle_tone1.83057704
33MP0001529_abnormal_vocalization1.78863774
34MP0001905_abnormal_dopamine_level1.78353563
35MP0000920_abnormal_myelination1.77070143
36MP0000955_abnormal_spinal_cord1.76861360
37MP0004924_abnormal_behavior1.71741680
38MP0005386_behavior/neurological_phenoty1.71741680
39MP0008569_lethality_at_weaning1.71611192
40MP0004885_abnormal_endolymph1.68922093
41MP0004858_abnormal_nervous_system1.60368016
42MP0004811_abnormal_neuron_physiology1.59988567
43MP0002557_abnormal_social/conspecific_i1.58956471
44MP0000516_abnormal_urinary_system1.56417659
45MP0005367_renal/urinary_system_phenotyp1.56417659
46MP0002882_abnormal_neuron_morphology1.55935901
47MP0009780_abnormal_chondrocyte_physiolo1.51554481
48MP0002066_abnormal_motor_capabilities/c1.49472734
49MP0000015_abnormal_ear_pigmentation1.47700059
50MP0005377_hearing/vestibular/ear_phenot1.40619599
51MP0003878_abnormal_ear_physiology1.40619599
52MP0005167_abnormal_blood-brain_barrier1.37928595
53MP0000534_abnormal_ureter_morphology1.34554651
54MP0005645_abnormal_hypothalamus_physiol1.32400004
55MP0001502_abnormal_circadian_rhythm1.30281071
56MP0001984_abnormal_olfaction1.28967952
57MP0004742_abnormal_vestibular_system1.28390753
58MP0000372_irregular_coat_pigmentation1.27473184
59MP0000566_synostosis1.25880859
60MP0003879_abnormal_hair_cell1.25687580
61MP0002229_neurodegeneration1.25135112
62MP0003634_abnormal_glial_cell1.24887645
63MP0000604_amyloidosis1.24781828
64MP0001756_abnormal_urination1.24305150
65MP0005388_respiratory_system_phenotype1.23080124
66MP0002133_abnormal_respiratory_system1.23080124
67MP0003633_abnormal_nervous_system1.20908409
68MP0003631_nervous_system_phenotype1.18738910
69MP0003690_abnormal_glial_cell1.15894010
70MP0005551_abnormal_eye_electrophysiolog1.15072756
71MP0005275_abnormal_skin_tensile1.14121382
72MP0005257_abnormal_intraocular_pressure1.13901720
73MP0002152_abnormal_brain_morphology1.13366016
74MP0005646_abnormal_pituitary_gland1.12193921
75MP0003632_abnormal_nervous_system1.11123039
76MP0002909_abnormal_adrenal_gland1.10613612
77MP0003122_maternal_imprinting1.06818413
78MP0003787_abnormal_imprinting1.06591188
79MP0001963_abnormal_hearing_physiology1.05048530
80MP0002752_abnormal_somatic_nervous1.01782348
81MP0000751_myopathy1.01729324
82MP0002638_abnormal_pupillary_reflex1.01009048
83MP0010368_abnormal_lymphatic_system0.96728440
84MP0002837_dystrophic_cardiac_calcinosis0.96461636
85MP0002295_abnormal_pulmonary_circulatio0.96113123
86MP0001485_abnormal_pinna_reflex0.93444078
87MP0005171_absent_coat_pigmentation0.91461264
88MP0000569_abnormal_digit_pigmentation0.90973714
89MP0004381_abnormal_hair_follicle0.90710357
90MP0002876_abnormal_thyroid_physiology0.89793452
91MP0001188_hyperpigmentation0.88431147
92MP0003123_paternal_imprinting0.87746895
93MP0004145_abnormal_muscle_electrophysio0.87071765
94MP0002069_abnormal_eating/drinking_beha0.86586893
95MP0005253_abnormal_eye_physiology0.84356037
96MP0005408_hypopigmentation0.82985601
97MP0001177_atelectasis0.79804240
98MP0001348_abnormal_lacrimal_gland0.78906282
99MP0004085_abnormal_heartbeat0.78619352
100MP0008874_decreased_physiological_sensi0.78111781
101MP0005508_abnormal_skeleton_morphology0.77038972
102MP0005174_abnormal_tail_pigmentation0.75767758
103MP0000631_abnormal_neuroendocrine_gland0.74667716
104MP0005535_abnormal_body_temperature0.74525424
105MP0008004_abnormal_stomach_pH0.74114024
106MP0002095_abnormal_skin_pigmentation0.73829083
107MP0001879_abnormal_lymphatic_vessel0.73355854
108MP0002090_abnormal_vision0.73119718
109MP0005623_abnormal_meninges_morphology0.73021921
110MP0005248_abnormal_Harderian_gland0.72662628
111MP0008438_abnormal_cutaneous_collagen0.72315365
112MP0005058_abnormal_lysosome_morphology0.70480142
113MP0008872_abnormal_physiological_respon0.68737576
114MP0001299_abnormal_eye_distance/0.68638318
115MP0005409_darkened_coat_color0.68056503
116MP0000013_abnormal_adipose_tissue0.67951199
117MP0000026_abnormal_inner_ear0.66884929
118MP0005410_abnormal_fertilization0.66234091
119MP0001664_abnormal_digestion0.65204219
120MP0003137_abnormal_impulse_conducting0.64330549
121MP0010386_abnormal_urinary_bladder0.64214781
122MP0006072_abnormal_retinal_apoptosis0.63540801
123MP0003861_abnormal_nervous_system0.63452505
124MP0001986_abnormal_taste_sensitivity0.62952976
125MP0003075_altered_response_to0.61912466
126MP0000747_muscle_weakness0.60398745
127MP0004484_altered_response_of0.60085514
128MP0003938_abnormal_ear_development0.57805070
129MP0001943_abnormal_respiration0.55165840
130MP0004043_abnormal_pH_regulation0.52426853
131MP0010769_abnormal_survival0.50814534
132MP0002082_postnatal_lethality0.49627894
133MP0010770_preweaning_lethality0.49627894
134MP0004215_abnormal_myocardial_fiber0.48673950
135MP0005195_abnormal_posterior_eye0.48594762

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.84831631
2Myokymia (HP:0002411)6.33617655
3Interstitial pulmonary disease (HP:0006530)5.52642028
4Focal seizures (HP:0007359)5.08630734
5Visual hallucinations (HP:0002367)4.63431072
6Atonic seizures (HP:0010819)4.58769134
7Epileptic encephalopathy (HP:0200134)4.52873206
8Supranuclear gaze palsy (HP:0000605)4.49049346
9Neurofibrillary tangles (HP:0002185)4.44149858
10Cerebral inclusion bodies (HP:0100314)4.22960118
11Absence seizures (HP:0002121)3.86831272
12Febrile seizures (HP:0002373)3.85460233
13Abnormality of the corticospinal tract (HP:0002492)3.82186283
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.82181452
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.82181452
16Dialeptic seizures (HP:0011146)3.76091096
17Ankle clonus (HP:0011448)3.72455738
18Progressive cerebellar ataxia (HP:0002073)3.52378319
19Generalized tonic-clonic seizures (HP:0002069)3.43447098
20Obstructive sleep apnea (HP:0002870)3.37930764
21Spastic gait (HP:0002064)3.36930348
22Dysmetria (HP:0001310)3.36677615
23Action tremor (HP:0002345)3.32336671
24Termporal pattern (HP:0011008)3.27581337
25Insidious onset (HP:0003587)3.27581337
26Hyperventilation (HP:0002883)3.26429868
27Growth hormone excess (HP:0000845)3.21315281
28Ocular albinism (HP:0001107)3.18297445
29Broad-based gait (HP:0002136)3.14791857
30Mutism (HP:0002300)3.08794363
31Urinary urgency (HP:0000012)3.05364038
32Iris hypopigmentation (HP:0007730)3.03035323
33Urinary bladder sphincter dysfunction (HP:0002839)2.98872849
34Systemic lupus erythematosus (HP:0002725)2.97933498
35Impaired vibration sensation in the lower limbs (HP:0002166)2.97069588
36Progressive inability to walk (HP:0002505)2.88672786
37Amblyopia (HP:0000646)2.79500744
38Dysdiadochokinesis (HP:0002075)2.76579849
39Gaze-evoked nystagmus (HP:0000640)2.75177035
40Depression (HP:0000716)2.74800642
41White forelock (HP:0002211)2.72886701
42Poor eye contact (HP:0000817)2.72444457
43Intention tremor (HP:0002080)2.67808147
44Truncal ataxia (HP:0002078)2.64924375
45Akinesia (HP:0002304)2.64254675
46Abnormal eating behavior (HP:0100738)2.64144522
47Nuclear cataract (HP:0100018)2.63968088
48Anxiety (HP:0000739)2.63667425
49Drooling (HP:0002307)2.59242942
50Excessive salivation (HP:0003781)2.59242942
51Pheochromocytoma (HP:0002666)2.59090614
52Scanning speech (HP:0002168)2.57055293
53Impaired social interactions (HP:0000735)2.55663054
54Abnormal social behavior (HP:0012433)2.55663054
55Postural instability (HP:0002172)2.53147674
56Mild short stature (HP:0003502)2.49355016
57Peripheral hypomyelination (HP:0007182)2.48637461
58Lower limb muscle weakness (HP:0007340)2.48268063
59Diplopia (HP:0000651)2.47505244
60Abnormality of binocular vision (HP:0011514)2.47505244
61Hemiparesis (HP:0001269)2.46461689
62Absent speech (HP:0001344)2.44541151
63Generalized myoclonic seizures (HP:0002123)2.42501323
64Epileptiform EEG discharges (HP:0011182)2.42485584
65Patchy hypopigmentation of hair (HP:0011365)2.39320279
66Delusions (HP:0000746)2.38557495
67Sleep apnea (HP:0010535)2.37762365
68Sensory axonal neuropathy (HP:0003390)2.37311989
69Annular pancreas (HP:0001734)2.34491281
70EEG with generalized epileptiform discharges (HP:0011198)2.32870039
71Cerebral aneurysm (HP:0004944)2.29956306
72Fetal akinesia sequence (HP:0001989)2.25172816
73Retinal dysplasia (HP:0007973)2.24924348
74Complement deficiency (HP:0004431)2.24497280
75Inability to walk (HP:0002540)2.24206308
76Neuroendocrine neoplasm (HP:0100634)2.23679181
77Thickened helices (HP:0000391)2.20513986
78Hypsarrhythmia (HP:0002521)2.20225873
79Tachypnea (HP:0002789)2.18577589
80Limb dystonia (HP:0002451)2.17999496
81Polyphagia (HP:0002591)2.17785353
82Genetic anticipation (HP:0003743)2.17459669
83Vascular tortuosity (HP:0004948)2.14195834
84Cerebral hypomyelination (HP:0006808)2.13796340
85Abnormality of the lower motor neuron (HP:0002366)2.12683144
86Torticollis (HP:0000473)2.12304804
87Heterochromia iridis (HP:0001100)2.10477427
88Hypoplasia of the iris (HP:0007676)2.10471149
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.09780506
90Bradykinesia (HP:0002067)2.09215482
91Onion bulb formation (HP:0003383)2.07574688
92Arterial tortuosity (HP:0005116)2.06214137
93Amyotrophic lateral sclerosis (HP:0007354)2.03032688
94Segmental peripheral demyelination/remyelination (HP:0003481)2.02524768
95Hypercortisolism (HP:0001578)2.02511637
96Abnormality of the fovea (HP:0000493)2.02120101
97Diminished motivation (HP:0000745)2.01391896
98Clonus (HP:0002169)2.00734844
99Glomerulonephritis (HP:0000099)1.99098400
100Aplasia/Hypoplasia of the macula (HP:0008059)1.98740823
101Focal dystonia (HP:0004373)1.97788403
102Prolonged QT interval (HP:0001657)1.96310526
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96001438
104Neuronal loss in central nervous system (HP:0002529)1.95866172
105Morphological abnormality of the pyramidal tract (HP:0002062)1.93014305
106Rapidly progressive (HP:0003678)1.92564111
107Papilledema (HP:0001085)1.90619107
108Megalencephaly (HP:0001355)1.90464683
109Protrusio acetabuli (HP:0003179)1.89760828
110Generalized hypopigmentation (HP:0007513)1.89136865
111Bronchomalacia (HP:0002780)1.87701173
112Postural tremor (HP:0002174)1.86822591
113Stereotypic behavior (HP:0000733)1.86732275
114Tetraplegia (HP:0002445)1.86092392
115Impaired vibratory sensation (HP:0002495)1.86002093
116Aplasia/Hypoplasia affecting the retina (HP:0008061)1.85490741
117Hypopigmentation of the fundus (HP:0007894)1.84809480
118Hemiplegia (HP:0002301)1.84363060
119Abnormality of salivation (HP:0100755)1.83632893
120Tubulointerstitial fibrosis (HP:0005576)1.82064809
121Increased circulating renin level (HP:0000848)1.81784216
122Status epilepticus (HP:0002133)1.81618929
123Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80870863
124Hypoplasia of the brainstem (HP:0002365)1.80870863
125Spinal cord compression (HP:0002176)1.80838370
126Spinal canal stenosis (HP:0003416)1.79494675
127Insomnia (HP:0100785)1.79420850
128Psychosis (HP:0000709)1.79156367
129Shallow orbits (HP:0000586)1.78905597
130Gait imbalance (HP:0002141)1.78132565
131Hammertoe (HP:0001765)1.77854906
132Craniofacial dystonia (HP:0012179)1.76049403
133Gait ataxia (HP:0002066)1.75618970
134Incomplete penetrance (HP:0003829)1.73651053
135Aplasia involving bones of the upper limbs (HP:0009823)1.73081168
136Aplasia of the phalanges of the hand (HP:0009802)1.73081168
137Aplasia involving bones of the extremities (HP:0009825)1.73081168
138Abnormal EKG (HP:0003115)1.73078444
139Apathy (HP:0000741)1.72882297
140Blue irides (HP:0000635)1.72603600
141Abnormal atrioventricular conduction (HP:0005150)1.71427729
142Alacrima (HP:0000522)1.71165592
143Bowel incontinence (HP:0002607)1.70737592
144Specific learning disability (HP:0001328)1.70311174
145Hypoplasia of the fovea (HP:0007750)1.70276295
146Aplasia/Hypoplasia of the fovea (HP:0008060)1.70276295
147Heart block (HP:0012722)1.70018164
148Adrenal overactivity (HP:0002717)1.69100445
149Atrioventricular block (HP:0001678)1.68872954
150Absent/shortened dynein arms (HP:0200106)1.68317578
151Dynein arm defect of respiratory motile cilia (HP:0012255)1.68317578
152Rigidity (HP:0002063)1.66247360
153Ulnar claw (HP:0001178)1.65375206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.27722064
2EPHA43.77686795
3MAP3K93.66951669
4RIPK13.39993354
5MARK13.26552219
6MINK12.49825585
7MAP3K42.49224694
8PNCK2.24004857
9NTRK12.17027341
10PAK62.07718073
11MAP2K72.05015362
12KSR22.04904354
13CASK2.03632913
14CDK191.99051131
15STK391.94282783
16OXSR11.93803338
17DDR21.83427818
18ARAF1.75249564
19NTRK21.67203359
20PRPF4B1.66690049
21MAP3K121.64135710
22DAPK21.62629395
23TIE11.61312579
24GRK51.55341558
25TNIK1.52650953
26PLK21.51814805
27CDK51.51286364
28KSR11.51087048
29MAP2K41.50258910
30UHMK11.38491280
31MAP3K131.37920339
32PRKD31.35004388
33MAPK131.31455628
34PHKG11.26774404
35PHKG21.26774404
36TRIB31.24470569
37RIPK41.23139288
38CAMK2A1.16463081
39MAPK121.15775341
40CAMK2B1.15379247
41FES1.14748083
42FGR1.14339186
43BCR1.13581955
44PKN11.12848487
45PRKCG1.12551066
46LIMK11.09619942
47SGK21.08822203
48PDGFRA1.08324341
49NME11.07772083
50CDK141.04292496
51CSNK1G21.04190089
52PAK31.04021547
53TYRO31.01419596
54MAP2K61.00919241
55CAMKK11.00014438
56MAP3K60.99793353
57PTK2B0.96247907
58CDK150.95728450
59CDK180.95359651
60SIK20.93128541
61MAP3K20.92423024
62CDK120.91449300
63ROCK20.90505261
64DAPK10.86282638
65WNK10.85500640
66LATS20.84164803
67SGK30.83816793
68CDK11A0.83221818
69WNK40.83208521
70SGK4940.83109524
71SGK2230.83109524
72STK110.82734910
73DYRK1A0.80730701
74MARK20.78059782
75CAMK2D0.76313183
76RPS6KA20.76051198
77RAF10.75792269
78TESK10.74543580
79CSNK1G30.73919711
80CAMK10.71871896
81PRKCE0.70662046
82ERBB20.70497591
83FGFR20.70083860
84BRD40.69757821
85PRKCH0.69582839
86CAMK2G0.69322118
87TNK20.64060421
88NEK60.62953091
89PRKD10.62693572
90RET0.60580271
91MAP3K110.59362871
92DYRK20.58546390
93BMPR20.58476954
94PDPK10.57488719
95LRRK20.56540983
96CDC42BPA0.56337830
97CSNK1A1L0.56278802
98PINK10.54824859
99EPHA30.53980435
100LMTK20.53403261
101MUSK0.53306031
102STK380.52994927
103MAPKAPK50.52740024
104SGK10.51360594
105CAMK1D0.51223981
106FER0.50883389
107CAMKK20.50763832
108ICK0.50613637
109ALK0.50245149
110PDK10.50194434
111PRKCZ0.49975492
112FGFR30.49754313
113ROCK10.48796591
114FYN0.48610013
115PDGFRB0.47000177
116CAMK1G0.46726407
117EPHB10.45552005
118MAPK70.43721009
119GRK70.43472681
120STK38L0.43354090
121MAPK100.43003609
122CCNB10.42254102
123HIPK20.40405826
124MAP3K10.39943689
125BRAF0.39407900
126CAMK40.39224725
127FGFR40.38563550
128CSNK1G10.38371130
129MAP3K70.36966041
130RPS6KA30.36689236
131DAPK30.35282314

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.85455967
2Synaptic vesicle cycle_Homo sapiens_hsa047213.42243656
3GABAergic synapse_Homo sapiens_hsa047272.81303430
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74891457
5Circadian entrainment_Homo sapiens_hsa047132.52617896
6Glutamatergic synapse_Homo sapiens_hsa047242.48123645
7Long-term potentiation_Homo sapiens_hsa047202.46940712
8Morphine addiction_Homo sapiens_hsa050322.46755003
9Olfactory transduction_Homo sapiens_hsa047402.38539184
10Amphetamine addiction_Homo sapiens_hsa050312.23990073
11Collecting duct acid secretion_Homo sapiens_hsa049662.08514778
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08259706
13Dopaminergic synapse_Homo sapiens_hsa047282.06751229
14Salivary secretion_Homo sapiens_hsa049702.06621454
15Serotonergic synapse_Homo sapiens_hsa047261.90791992
16Taste transduction_Homo sapiens_hsa047421.85127469
17Cholinergic synapse_Homo sapiens_hsa047251.79105779
18Gastric acid secretion_Homo sapiens_hsa049711.73267648
19Long-term depression_Homo sapiens_hsa047301.71765840
20Insulin secretion_Homo sapiens_hsa049111.68460760
21Renin secretion_Homo sapiens_hsa049241.59640745
22Axon guidance_Homo sapiens_hsa043601.56030899
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54837620
24Oxytocin signaling pathway_Homo sapiens_hsa049211.53033539
25Calcium signaling pathway_Homo sapiens_hsa040201.51786653
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51261878
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51189605
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50074031
29Cocaine addiction_Homo sapiens_hsa050301.49499372
30Vibrio cholerae infection_Homo sapiens_hsa051101.34932395
31Cardiac muscle contraction_Homo sapiens_hsa042601.33404321
32Oxidative phosphorylation_Homo sapiens_hsa001901.32819614
33Gap junction_Homo sapiens_hsa045401.32012598
34GnRH signaling pathway_Homo sapiens_hsa049121.31058420
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28803306
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25957053
37Bile secretion_Homo sapiens_hsa049761.16723089
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13862935
39cAMP signaling pathway_Homo sapiens_hsa040241.13778460
40Alzheimers disease_Homo sapiens_hsa050101.11787581
41ECM-receptor interaction_Homo sapiens_hsa045121.09708005
42Circadian rhythm_Homo sapiens_hsa047101.06069722
43ErbB signaling pathway_Homo sapiens_hsa040121.04217046
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04179889
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01657040
46Estrogen signaling pathway_Homo sapiens_hsa049151.01542405
47Phototransduction_Homo sapiens_hsa047441.01090506
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98630886
49Melanogenesis_Homo sapiens_hsa049160.96862516
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.95687193
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.93548214
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90847551
53Parkinsons disease_Homo sapiens_hsa050120.89646843
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88971212
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88186563
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86782687
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86199400
58Glioma_Homo sapiens_hsa052140.85702362
59Lysosome_Homo sapiens_hsa041420.85500666
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.83703276
61Vitamin B6 metabolism_Homo sapiens_hsa007500.83558050
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.82841548
63Type II diabetes mellitus_Homo sapiens_hsa049300.81206034
64Pertussis_Homo sapiens_hsa051330.77460426
65Dorso-ventral axis formation_Homo sapiens_hsa043200.77197377
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76645238
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74893008
68Oocyte meiosis_Homo sapiens_hsa041140.73768644
69Pancreatic secretion_Homo sapiens_hsa049720.72694372
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71685216
71Choline metabolism in cancer_Homo sapiens_hsa052310.70907567
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69023808
73MAPK signaling pathway_Homo sapiens_hsa040100.67769202
74Ether lipid metabolism_Homo sapiens_hsa005650.67227552
75Ras signaling pathway_Homo sapiens_hsa040140.65177833
76Mineral absorption_Homo sapiens_hsa049780.64811601
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64129116
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.63931712
79ABC transporters_Homo sapiens_hsa020100.63682697
80Histidine metabolism_Homo sapiens_hsa003400.63534301
81Protein digestion and absorption_Homo sapiens_hsa049740.61761887
82Thyroid hormone synthesis_Homo sapiens_hsa049180.61753097
83Focal adhesion_Homo sapiens_hsa045100.61372359
84Dilated cardiomyopathy_Homo sapiens_hsa054140.59254731
85Butanoate metabolism_Homo sapiens_hsa006500.58980236
86Notch signaling pathway_Homo sapiens_hsa043300.57614904
87Renal cell carcinoma_Homo sapiens_hsa052110.56846485
88Huntingtons disease_Homo sapiens_hsa050160.56666173
89Prion diseases_Homo sapiens_hsa050200.56446142
90Other glycan degradation_Homo sapiens_hsa005110.54124977
91Endocytosis_Homo sapiens_hsa041440.51563459
92Rheumatoid arthritis_Homo sapiens_hsa053230.49823268
93VEGF signaling pathway_Homo sapiens_hsa043700.48688377
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47394590
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47376882
96Alcoholism_Homo sapiens_hsa050340.47310241
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47139521
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46924199
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46709904
100Type I diabetes mellitus_Homo sapiens_hsa049400.45576977
101Rap1 signaling pathway_Homo sapiens_hsa040150.45306655
102Wnt signaling pathway_Homo sapiens_hsa043100.44250681
103Hippo signaling pathway_Homo sapiens_hsa043900.44048940
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43004515
105Amoebiasis_Homo sapiens_hsa051460.42013613
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40753321
107Ovarian steroidogenesis_Homo sapiens_hsa049130.40540403
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39608031
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37284650
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.36828446
111Fatty acid elongation_Homo sapiens_hsa000620.36671960
112Inositol phosphate metabolism_Homo sapiens_hsa005620.33583493
113Steroid biosynthesis_Homo sapiens_hsa001000.32875380
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.31718355
115Tight junction_Homo sapiens_hsa045300.31715242
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30289168
117Glucagon signaling pathway_Homo sapiens_hsa049220.30012493
118Phagosome_Homo sapiens_hsa041450.29259171
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28768318
120African trypanosomiasis_Homo sapiens_hsa051430.28060594
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27350596
122Nitrogen metabolism_Homo sapiens_hsa009100.27270248

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