CRTAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)8.95524837
2regulation of RIG-I signaling pathway (GO:0039535)8.54054244
3regulation of isotype switching to IgG isotypes (GO:0048302)8.10290357
4necroptotic process (GO:0070266)8.02034718
5negative regulation of necroptotic process (GO:0060546)7.90217924
6regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)7.51793377
7negative T cell selection (GO:0043383)6.58009994
8negative regulation of necrotic cell death (GO:0060547)6.43820470
9positive regulation of gamma-delta T cell activation (GO:0046645)6.42459793
10interferon-gamma production (GO:0032609)6.38882263
11regulation of necroptotic process (GO:0060544)6.23041985
12positive regulation of B cell mediated immunity (GO:0002714)6.22546579
13positive regulation of immunoglobulin mediated immune response (GO:0002891)6.22546579
14negative thymic T cell selection (GO:0045060)6.16489840
15programmed necrotic cell death (GO:0097300)6.03762179
16fusion of sperm to egg plasma membrane (GO:0007342)6.01007177
17positive regulation of protein homooligomerization (GO:0032464)5.96828659
18cell wall macromolecule catabolic process (GO:0016998)5.86520361
19cell wall macromolecule metabolic process (GO:0044036)5.86520361
20positive regulation of isotype switching (GO:0045830)5.84195643
21negative regulation of interleukin-12 production (GO:0032695)5.82613400
22positive regulation of T cell chemotaxis (GO:0010820)5.78403455
23regulation of T cell chemotaxis (GO:0010819)5.78403455
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.75807703
25negative regulation of cell killing (GO:0031342)5.73568458
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.73568458
27necrotic cell death (GO:0070265)5.62968038
28positive thymic T cell selection (GO:0045059)5.38555083
29acrosome assembly (GO:0001675)5.31986589
30negative regulation of T cell mediated immunity (GO:0002710)5.25344837
31regulation of immunoglobulin mediated immune response (GO:0002889)5.16537515
32positive T cell selection (GO:0043368)5.11406792
33multicellular organism reproduction (GO:0032504)5.10020304
34positive regulation of alpha-beta T cell proliferation (GO:0046641)5.04710100
35cilium or flagellum-dependent cell motility (GO:0001539)5.02736810
36regulation of gamma-delta T cell differentiation (GO:0045586)5.02640966
37regulation of B cell mediated immunity (GO:0002712)4.96698913
38positive regulation of DNA recombination (GO:0045911)4.91389786
39sperm-egg recognition (GO:0035036)4.88332884
40positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.87884712
41thymic T cell selection (GO:0045061)4.80481223
42regulation of alpha-beta T cell proliferation (GO:0046640)4.79919406
43regulation of podosome assembly (GO:0071801)4.78944176
44regulation of interleukin-12 biosynthetic process (GO:0045075)4.77931936
45cellular response to interleukin-15 (GO:0071350)4.75556667
46cell-cell recognition (GO:0009988)4.73309210
47T cell migration (GO:0072678)4.72407895
48negative regulation of reactive oxygen species metabolic process (GO:2000378)4.71800330
49regulation of isotype switching (GO:0045191)4.67944875
50response to interleukin-15 (GO:0070672)4.66911533
51positive regulation of humoral immune response (GO:0002922)4.59091875
52sperm motility (GO:0030317)4.55952891
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.54000939
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54000939
55regulation of gamma-delta T cell activation (GO:0046643)4.52501094
56regulation of regulatory T cell differentiation (GO:0045589)4.52244026
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.47970979
58plasma membrane fusion (GO:0045026)4.45951956
59positive regulation of T cell cytokine production (GO:0002726)4.44784169
60DNA deamination (GO:0045006)4.35813042
61regulation of B cell receptor signaling pathway (GO:0050855)4.34556003
62piRNA metabolic process (GO:0034587)4.34531187
63myeloid dendritic cell differentiation (GO:0043011)4.34279774
64positive regulation of immunoglobulin production (GO:0002639)4.33990436
65* positive regulation of natural killer cell mediated immunity (GO:0002717)4.29389282
66* positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.29389282
67* regulation of natural killer cell mediated immunity (GO:0002715)4.25322650
68* regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.25322650
69regulation of lymphocyte chemotaxis (GO:1901623)4.23278294
70T cell selection (GO:0045058)4.21255147
71reproduction (GO:0000003)4.17362378
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.16475913
73negative regulation of lymphocyte mediated immunity (GO:0002707)4.16242691
74* positive regulation of cell killing (GO:0031343)4.14311770
75cellular response to lithium ion (GO:0071285)4.12476023
76myeloid dendritic cell activation (GO:0001773)4.11040393
77* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.08511788
78positive regulation of interleukin-10 production (GO:0032733)4.05771428
79binding of sperm to zona pellucida (GO:0007339)4.05579503
80antigen processing and presentation of endogenous antigen (GO:0019883)4.05485485
81regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.02741951
82T cell costimulation (GO:0031295)3.99904767
83leukocyte aggregation (GO:0070486)3.97885303
84lymphocyte migration (GO:0072676)3.95409163
85hepatocyte apoptotic process (GO:0097284)3.94150019
86lymphocyte costimulation (GO:0031294)3.90834499
87positive regulation of T-helper 1 type immune response (GO:0002827)3.90641059
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.88894559
89mucosal-associated lymphoid tissue development (GO:0048537)3.87003997
90Peyers patch development (GO:0048541)3.87003997
91* regulation of leukocyte mediated cytotoxicity (GO:0001910)3.82190895
92acrosome reaction (GO:0007340)3.82013434
93positive regulation of NF-kappaB import into nucleus (GO:0042346)3.81087340
94* regulation of cell killing (GO:0031341)3.80301772
95regulation of B cell differentiation (GO:0045577)3.79616111
96T cell receptor signaling pathway (GO:0050852)3.78372998
97regulation of immunoglobulin production (GO:0002637)3.77267958
98positive regulation of lymphocyte migration (GO:2000403)3.76458517
99regulation of necrotic cell death (GO:0010939)3.76068011
100* activated T cell proliferation (GO:0050798)3.75553457
101cellular defense response (GO:0006968)3.70883178
102* positive regulation of lymphocyte mediated immunity (GO:0002708)3.69719821
103T cell homeostasis (GO:0043029)3.68612626
104negative regulation of inclusion body assembly (GO:0090084)3.66771753
105cytidine deamination (GO:0009972)3.66575160
106cytidine metabolic process (GO:0046087)3.66575160
107cytidine catabolic process (GO:0006216)3.66575160
108positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.62342271
109CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.60651597
110regulation of T cell tolerance induction (GO:0002664)3.56317312
111regulation of tolerance induction (GO:0002643)3.56258512
112axonemal dynein complex assembly (GO:0070286)3.54058572
113lymphocyte chemotaxis (GO:0048247)3.50227699
114natural killer cell differentiation (GO:0001779)3.47262757
115positive regulation of T cell mediated cytotoxicity (GO:0001916)3.47167482
116motile cilium assembly (GO:0044458)3.45744560
117positive regulation of T cell migration (GO:2000406)3.43828467
118cytolysis (GO:0019835)3.36217361
119oxygen transport (GO:0015671)3.33238580
120regulation of interleukin-2 biosynthetic process (GO:0045076)3.32592303
121regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31966941
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31228026
123* regulation of lymphocyte mediated immunity (GO:0002706)3.31211564
124T cell apoptotic process (GO:0070231)3.29096490
125defense response to protozoan (GO:0042832)3.28503658
126L-alpha-amino acid transmembrane transport (GO:1902475)3.27917610
127pyrimidine ribonucleoside catabolic process (GO:0046133)3.27244135
128male meiosis (GO:0007140)3.24781300
129* positive regulation of leukocyte mediated immunity (GO:0002705)3.24159024
130production of molecular mediator of immune response (GO:0002440)3.24122094
131negative regulation of B cell activation (GO:0050869)3.23707315
132natural killer cell activation (GO:0030101)3.22147614
133regulation of T cell mediated cytotoxicity (GO:0001914)3.21005127
134regulation of interleukin-10 production (GO:0032653)3.20640954
135negative regulation of T-helper cell differentiation (GO:0045623)3.19695830
136negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.19695830
137spermatid development (GO:0007286)3.17077920
138mast cell activation (GO:0045576)3.15944650
139regulation of chronic inflammatory response (GO:0002676)3.15338737
140regulation of T-helper 1 type immune response (GO:0002825)3.14179497
141negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.13450216
142positive regulation of tolerance induction (GO:0002645)3.13178619
143regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12291316
144* T cell proliferation (GO:0042098)3.12068605
145positive regulation of defense response to virus by host (GO:0002230)3.11049907
146positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.10117070
147Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05048278
148natural killer cell activation involved in immune response (GO:0002323)3.03745656
149L-fucose catabolic process (GO:0042355)3.00569288
150fucose catabolic process (GO:0019317)3.00569288
151L-fucose metabolic process (GO:0042354)3.00569288
152regulation of toll-like receptor signaling pathway (GO:0034121)3.00526304
153positive regulation of protein oligomerization (GO:0032461)2.94124073
154lymphocyte apoptotic process (GO:0070227)2.93441164
155regulation of T cell migration (GO:2000404)2.93430161
156positive regulation of granulocyte differentiation (GO:0030854)2.93164689
157regulation of protein homooligomerization (GO:0032462)2.89988958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.37592445
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.83136623
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.77391962
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.10611770
5* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.66650055
6RUNX_20019798_ChIP-Seq_JUKART_Human3.62991318
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.32742023
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.27788866
9MYB_26560356_Chip-Seq_TH2_Human2.98846935
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96093855
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.87022385
12VDR_22108803_ChIP-Seq_LS180_Human2.75399561
13IGF1R_20145208_ChIP-Seq_DFB_Human2.69572836
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66824326
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66497612
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55628420
17MYB_26560356_Chip-Seq_TH1_Human2.49204894
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.41011716
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37994516
20ZNF274_21170338_ChIP-Seq_K562_Hela2.37829134
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.34668707
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.29766372
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24199655
24MAF_26560356_Chip-Seq_TH1_Human2.23653403
25UTX_26944678_Chip-Seq_JUKART_Human2.16723633
26MYC_22102868_ChIP-Seq_BL_Human2.12006079
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.05826828
28GATA3_27048872_Chip-Seq_THYMUS_Human2.05308690
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03625547
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.02520696
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99218110
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.91043886
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80955184
34GATA1_22025678_ChIP-Seq_K562_Human1.80914334
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.80793406
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.75276873
37MAF_26560356_Chip-Seq_TH2_Human1.74098654
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72901288
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65018635
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63539576
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60525412
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.56889346
43VDR_23849224_ChIP-Seq_CD4+_Human1.48787405
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.48571388
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42503199
46TCF7_22412390_ChIP-Seq_EML_Mouse1.41742013
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39829555
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.38361704
49ER_23166858_ChIP-Seq_MCF-7_Human1.37637790
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36764598
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34434408
52GATA3_26560356_Chip-Seq_TH2_Human1.34050246
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31612599
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30886577
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30455789
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30190943
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29906044
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29643352
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26992534
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26817982
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26318837
62DROSHA_22980978_ChIP-Seq_HELA_Human1.25990190
63FOXP3_21729870_ChIP-Seq_TREG_Human1.25122639
64KDM2B_26808549_Chip-Seq_DND41_Human1.25058523
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22484448
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22448813
67* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19778032
68GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.17956924
69AR_21572438_ChIP-Seq_LNCaP_Human1.17213745
70SPI1_23547873_ChIP-Seq_NB4_Human1.16485795
71LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.16269647
72VDR_24763502_ChIP-Seq_THP-1_Human1.16249094
73SPI1_23127762_ChIP-Seq_K562_Human1.15943100
74HOXB7_26014856_ChIP-Seq_BT474_Human1.13817193
75TP53_22573176_ChIP-Seq_HFKS_Human1.13125330
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.13045953
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12471684
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12306064
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09198495
80PU_27001747_Chip-Seq_BMDM_Mouse1.09175640
81FLI1_21867929_ChIP-Seq_CD8_Mouse1.08571071
82* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08319949
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07398467
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05827373
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05360010
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04429625
87WDR5_24793694_ChIP-Seq_LNCAP_Human1.01717833
88ELK1_19687146_ChIP-ChIP_HELA_Human1.01428683
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01171930
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00591593
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99983917
92TAF2_19829295_ChIP-Seq_ESCs_Human0.99854615
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98577692
94EZH2_22144423_ChIP-Seq_EOC_Human0.98420183
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98257285
96EGR1_19374776_ChIP-ChIP_THP-1_Human0.98163742
97* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98015070
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97744925
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96065923
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96023232
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96021112
102* SPI1_20517297_ChIP-Seq_HL60_Human0.95153229
103* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95078694
104* VDR_24787735_ChIP-Seq_THP-1_Human0.94852546
105ETS1_20019798_ChIP-Seq_JURKAT_Human0.94174984
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94086425
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93465776
108PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92848003
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92482558
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91180473
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91022004
112RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90833320
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90715950
114* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89920100
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89907124
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89789288
117VDR_21846776_ChIP-Seq_THP-1_Human0.89401386
118NMYC_18555785_Chip-Seq_ESCs_Mouse0.88953268
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88321824
120PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87666964
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.87375091
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87212605
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86729309
124CEBPB_22108803_ChIP-Seq_LS180_Human0.86497289
125GATA3_26560356_Chip-Seq_TH1_Human0.85816058
126BCAT_22108803_ChIP-Seq_LS180_Human0.85554245
127SALL4_22934838_ChIP-ChIP_CD34+_Human0.85195314
128OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85163195
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84946289
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84744317
131P300_18555785_Chip-Seq_ESCs_Mouse0.84741193
132* GATA3_21878914_ChIP-Seq_MCF-7_Human0.84344538
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.84144301
134REST_21632747_ChIP-Seq_MESCs_Mouse0.83883582
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83639441
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83068611
137RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81797234
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81633040
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80947979
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.80416879
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79474203
142EWS_26573619_Chip-Seq_HEK293_Human0.78889258
143LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78690097
144SMAD1_18555785_Chip-Seq_ESCs_Mouse0.78564348
145OCT4_18555785_Chip-Seq_ESCs_Mouse0.78538585
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78492752
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78346898
148MYC_18940864_ChIP-ChIP_HL60_Human0.78196411
149FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77815358
150* FOXA1_25329375_ChIP-Seq_VCAP_Human0.77501235
151* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77501235
152FLI1_21867929_ChIP-Seq_TH2_Mouse0.76980630
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.76926657
154ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76891781
155TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76512074
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.76054214
157FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75791568
158SMRT_27268052_Chip-Seq_Bcells_Human0.75666227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology5.48444848
2MP0005671_abnormal_response_to5.43549639
3MP0005410_abnormal_fertilization5.29471813
4MP0003763_abnormal_thymus_physiology4.79248401
5MP0001835_abnormal_antigen_presentation4.16448350
6MP0006082_CNS_inflammation3.63401023
7MP0005379_endocrine/exocrine_gland_phen3.23765301
8MP0000685_abnormal_immune_system3.01605632
9MP0002405_respiratory_system_inflammati2.93314310
10MP0001873_stomach_inflammation2.86381317
11MP0009333_abnormal_splenocyte_physiolog2.84292936
12MP0005670_abnormal_white_adipose2.80417108
13MP0009785_altered_susceptibility_to2.79480981
14MP0002876_abnormal_thyroid_physiology2.79393664
15MP0001800_abnormal_humoral_immune2.76972752
16MP0005000_abnormal_immune_tolerance2.70898612
17MP0001346_abnormal_lacrimal_gland2.66164226
18MP0003436_decreased_susceptibility_to2.55361219
19MP0003300_gastrointestinal_ulcer2.46299947
20* MP0002420_abnormal_adaptive_immunity2.42227963
21* MP0001819_abnormal_immune_cell2.35687591
22MP0008961_abnormal_basal_metabolism2.34288012
23* MP0002723_abnormal_immune_serum2.33609056
24* MP0002398_abnormal_bone_marrow2.31644818
25MP0005645_abnormal_hypothalamus_physiol2.27013124
26MP0003866_abnormal_defecation2.25942315
27MP0000703_abnormal_thymus_morphology2.22387721
28MP0002148_abnormal_hypersensitivity_rea2.16334872
29* MP0005025_abnormal_response_to2.16178429
30MP0002452_abnormal_antigen_presenting2.08053824
31MP0005387_immune_system_phenotype2.07300381
32MP0001790_abnormal_immune_system2.07300381
33MP0000569_abnormal_digit_pigmentation2.05275195
34MP0002102_abnormal_ear_morphology2.03462521
35* MP0000716_abnormal_immune_system2.01157771
36MP0003698_abnormal_male_reproductive1.93620445
37MP0008877_abnormal_DNA_methylation1.92943933
38MP0008569_lethality_at_weaning1.90219259
39MP0009046_muscle_twitch1.88465604
40MP0002166_altered_tumor_susceptibility1.87001805
41MP0004510_myositis1.81145915
42MP0002722_abnormal_immune_system1.80221645
43MP0001929_abnormal_gametogenesis1.75161287
44MP0000689_abnormal_spleen_morphology1.70571683
45MP0001986_abnormal_taste_sensitivity1.68018864
46MP0001501_abnormal_sleep_pattern1.67098563
47MP0010155_abnormal_intestine_physiology1.60737212
48MP0002006_tumorigenesis1.58909103
49* MP0002429_abnormal_blood_cell1.58058282
50MP0000604_amyloidosis1.55164602
51MP0003448_altered_tumor_morphology1.54904598
52MP0002419_abnormal_innate_immunity1.48234541
53MP0005167_abnormal_blood-brain_barrier1.47788743
54MP0001845_abnormal_inflammatory_respons1.44567880
55MP0000858_altered_metastatic_potential1.30547303
56MP0003045_fibrosis1.29579297
57MP0004381_abnormal_hair_follicle1.28672805
58MP0004043_abnormal_pH_regulation1.20046220
59MP0002138_abnormal_hepatobiliary_system1.18382297
60MP0001853_heart_inflammation1.17058063
61MP0001502_abnormal_circadian_rhythm1.14750099
62MP0004947_skin_inflammation1.14466957
63MP0001968_abnormal_touch/_nociception1.14150156
64MP0008057_abnormal_DNA_replication1.13828385
65MP0002396_abnormal_hematopoietic_system1.13739413
66MP0002132_abnormal_respiratory_system1.13306099
67MP0002210_abnormal_sex_determination1.09202068
68MP0001851_eye_inflammation1.08358291
69MP0010307_abnormal_tumor_latency1.08179241
70MP0004859_abnormal_synaptic_plasticity1.05464349
71MP0002161_abnormal_fertility/fecundity1.04229788
72MP0002933_joint_inflammation1.03021357
73MP0003646_muscle_fatigue1.00633941
74MP0005464_abnormal_platelet_physiology0.99951896
75MP0002877_abnormal_melanocyte_morpholog0.97127451
76MP0004084_abnormal_cardiac_muscle0.95710708
77MP0001905_abnormal_dopamine_level0.92252486
78MP0004142_abnormal_muscle_tone0.88656856
79MP0003635_abnormal_synaptic_transmissio0.87384504
80MP0005448_abnormal_energy_balance0.84113982
81MP0003724_increased_susceptibility_to0.83722012
82MP0004808_abnormal_hematopoietic_stem0.83361588
83MP0003183_abnormal_peptide_metabolism0.82455602
84MP0005310_abnormal_salivary_gland0.81613013
85MP0004782_abnormal_surfactant_physiolog0.81537846
86MP0001145_abnormal_male_reproductive0.81296263
87MP0004742_abnormal_vestibular_system0.78385626
88MP0002019_abnormal_tumor_incidence0.77828861
89MP0008469_abnormal_protein_level0.77508720
90MP0001440_abnormal_grooming_behavior0.75471291
91MP0003303_peritoneal_inflammation0.75466208
92MP0001533_abnormal_skeleton_physiology0.75173426
93MP0004215_abnormal_myocardial_fiber0.74370772
94MP0003195_calcinosis0.74301157
95MP0002009_preneoplasia0.73233430
96MP0004885_abnormal_endolymph0.72909959
97MP0000653_abnormal_sex_gland0.72539474
98MP0005166_decreased_susceptibility_to0.72007808
99MP0005084_abnormal_gallbladder_morpholo0.71984630
100MP0002277_abnormal_respiratory_mucosa0.71905347
101MP0002733_abnormal_thermal_nociception0.71031962
102MP0005451_abnormal_body_composition0.70169934
103MP0002272_abnormal_nervous_system0.69410763
104MP0009745_abnormal_behavioral_response0.69207359
105MP0006072_abnormal_retinal_apoptosis0.68861583
106MP0001919_abnormal_reproductive_system0.68562223
107MP0008875_abnormal_xenobiotic_pharmacok0.68503114
108MP0002254_reproductive_system_inflammat0.68320950
109MP0002998_abnormal_bone_remodeling0.68232954
110MP0002837_dystrophic_cardiac_calcinosis0.68228717
111MP0000465_gastrointestinal_hemorrhage0.68038530
112MP0000920_abnormal_myelination0.67267945
113MP0003329_amyloid_beta_deposits0.65684042
114MP0001984_abnormal_olfaction0.65603007
115MP0003633_abnormal_nervous_system0.65504858
116MP0008872_abnormal_physiological_respon0.65401854
117MP0009765_abnormal_xenobiotic_induced0.63379331
118MP0002653_abnormal_ependyma_morphology0.63030987
119MP0001348_abnormal_lacrimal_gland0.62257741
120MP0005423_abnormal_somatic_nervous0.61526810
121MP0003567_abnormal_fetal_cardiomyocyte0.61509183
122MP0009763_increased_sensitivity_to0.61312615
123MP0001958_emphysema0.61220202
124MP0005551_abnormal_eye_electrophysiolog0.59920262
125MP0002083_premature_death0.58916845
126MP0005083_abnormal_biliary_tract0.57491203
127MP0002064_seizures0.57295102
128MP0001663_abnormal_digestive_system0.57236693
129MP0009764_decreased_sensitivity_to0.56353570
130MP0006036_abnormal_mitochondrial_physio0.56350934
131MP0000427_abnormal_hair_cycle0.55324612
132MP0003959_abnormal_lean_body0.55297222
133MP0005389_reproductive_system_phenotype0.55190931
134MP0004145_abnormal_muscle_electrophysio0.54047832
135MP0008873_increased_physiological_sensi0.53586291
136MP0008058_abnormal_DNA_repair0.53459569
137MP0001881_abnormal_mammary_gland0.53046950
138MP0005647_abnormal_sex_gland0.52951224
139MP0004036_abnormal_muscle_relaxation0.52677615
140MP0005623_abnormal_meninges_morphology0.52343467
141MP0005408_hypopigmentation0.51474294
142MP0002067_abnormal_sensory_capabilities0.50877612
143MP0010352_gastrointestinal_tract_polyps0.50437442
144MP0002693_abnormal_pancreas_physiology0.49192737

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)8.03992462
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.99873102
3Abnormality of the nasal mucosa (HP:0000433)6.45626287
4T lymphocytopenia (HP:0005403)6.36400023
5Abnormality of T cell number (HP:0011839)6.05653910
6Absent/shortened dynein arms (HP:0200106)5.74694838
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.74694838
8Autoimmune thrombocytopenia (HP:0001973)5.23496955
9Recurrent bronchitis (HP:0002837)4.95381852
10Stomatitis (HP:0010280)4.61636233
11Abnormal respiratory motile cilium physiology (HP:0012261)4.60591106
12Elevated erythrocyte sedimentation rate (HP:0003565)4.37302206
13Bronchitis (HP:0012387)4.34357295
14Hypoproteinemia (HP:0003075)4.28148019
15Rhinitis (HP:0012384)4.04007730
16Abnormality of T cells (HP:0002843)4.02061342
17Severe combined immunodeficiency (HP:0004430)4.00721897
18Oligodactyly (hands) (HP:0001180)3.94899445
19Eosinophilia (HP:0001880)3.88843943
20Eczematoid dermatitis (HP:0000976)3.86562571
21Combined immunodeficiency (HP:0005387)3.84350270
22Bronchiectasis (HP:0002110)3.83144713
23Abnormal respiratory epithelium morphology (HP:0012253)3.73698079
24Abnormal respiratory motile cilium morphology (HP:0005938)3.73698079
25Fatigue (HP:0012378)3.65272585
26Recurrent fungal infections (HP:0002841)3.55212663
27Abnormal ciliary motility (HP:0012262)3.52851684
28Chronic otitis media (HP:0000389)3.52487812
29Recurrent sinusitis (HP:0011108)3.42896648
30Chronic bronchitis (HP:0004469)3.42820459
31Papilledema (HP:0001085)3.40935904
32Abnormality of binocular vision (HP:0011514)3.36220563
33Diplopia (HP:0000651)3.36220563
34Panhypogammaglobulinemia (HP:0003139)3.34792459
35Chronic mucocutaneous candidiasis (HP:0002728)3.30806701
36Recurrent cutaneous fungal infections (HP:0011370)3.30806701
37Myositis (HP:0100614)3.19326929
38Abnormality of ocular smooth pursuit (HP:0000617)3.14301485
39Hypochromic anemia (HP:0001931)3.12020115
40Impaired smooth pursuit (HP:0007772)3.11896536
41Amyotrophic lateral sclerosis (HP:0007354)3.11469947
42Molar tooth sign on MRI (HP:0002419)3.11092735
43Abnormality of midbrain morphology (HP:0002418)3.11092735
44Abnormality of the renal cortex (HP:0011035)3.09200209
45Chronic diarrhea (HP:0002028)3.01284878
46Recurrent viral infections (HP:0004429)3.00385750
47Granulocytopenia (HP:0001913)2.98936120
48Keratoconjunctivitis sicca (HP:0001097)2.98421656
49Dysmetric saccades (HP:0000641)2.98318184
50Recurrent otitis media (HP:0000403)2.98110680
51Mediastinal lymphadenopathy (HP:0100721)2.95654848
523-Methylglutaconic aciduria (HP:0003535)2.94606008
53Oligodactyly (HP:0012165)2.93986564
54Joint swelling (HP:0001386)2.92815393
55IgG deficiency (HP:0004315)2.85630879
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.83779084
57Infertility (HP:0000789)2.82867992
58Volvulus (HP:0002580)2.82059575
59Congenital stationary night blindness (HP:0007642)2.77930042
60Chronic sinusitis (HP:0011109)2.77436934
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.76940689
62Gastrointestinal infarctions (HP:0005244)2.75267138
63Large eyes (HP:0001090)2.75177099
64Degeneration of anterior horn cells (HP:0002398)2.74946892
65Abnormality of the anterior horn cell (HP:0006802)2.74946892
66Optic neuritis (HP:0100653)2.72809785
67Retrobulbar optic neuritis (HP:0100654)2.72809785
68Double outlet right ventricle (HP:0001719)2.72385007
69Congenital malformation of the right heart (HP:0011723)2.72385007
70Hemiplegia (HP:0002301)2.70800664
71Gaze-evoked nystagmus (HP:0000640)2.68962880
72Tongue fasciculations (HP:0001308)2.68890948
73Abnormality of the lower motor neuron (HP:0002366)2.67093039
74Pulmonary infiltrates (HP:0002113)2.59209048
75Action tremor (HP:0002345)2.54416821
76Abnormality of the pons (HP:0007361)2.53732022
77Abnormality of the renal medulla (HP:0100957)2.53383028
78Progressive cerebellar ataxia (HP:0002073)2.49472885
79Abnormality of the gastric mucosa (HP:0004295)2.49385479
80Inflammation of the large intestine (HP:0002037)2.48119419
81Abnormality of saccadic eye movements (HP:0000570)2.47032877
82Febrile seizures (HP:0002373)2.43383385
83Meningitis (HP:0001287)2.42875293
84Acute hepatic failure (HP:0006554)2.40121725
85Tetraplegia (HP:0002445)2.37134349
86Muscle fibrillation (HP:0010546)2.35587802
87Recurrent abscess formation (HP:0002722)2.35078114
88Gastrointestinal inflammation (HP:0004386)2.34966737
89IgM deficiency (HP:0002850)2.34855276
90Orchitis (HP:0100796)2.27630962
91Encephalitis (HP:0002383)2.25483903
92Abnormality of eosinophils (HP:0001879)2.25178293
93Obstructive lung disease (HP:0006536)2.22939474
94Chronic obstructive pulmonary disease (HP:0006510)2.22939474
95Hypoalbuminemia (HP:0003073)2.21496070
96Abnormal albumin level (HP:0012116)2.21496070
97Arterial thrombosis (HP:0004420)2.20975336
98Pustule (HP:0200039)2.19015851
99Progressive inability to walk (HP:0002505)2.15399698
100Increased IgM level (HP:0003496)2.13072575
101Hypoplasia of the pons (HP:0012110)2.11368807
102Lymphopenia (HP:0001888)2.11319577
103Spinal muscular atrophy (HP:0007269)2.10697225
104Nephronophthisis (HP:0000090)2.09928000
105Recurrent skin infections (HP:0001581)2.08968095
106Alveolar cell carcinoma (HP:0006519)2.07316403
107Hemoptysis (HP:0002105)2.06951541
108Abnormality of cells of the lymphoid lineage (HP:0012140)2.06061959
109Aplasia/Hypoplasia of the spleen (HP:0010451)2.05210379
110Hypokalemic alkalosis (HP:0001949)2.04955379
111Spontaneous hematomas (HP:0007420)2.03045205
112Keratitis (HP:0000491)2.02628299
113Keratoconjunctivitis (HP:0001096)2.01216486
114Widely spaced teeth (HP:0000687)2.00265734
115Metabolic alkalosis (HP:0200114)1.99615307
116Testicular atrophy (HP:0000029)1.98647404
117Thyroiditis (HP:0100646)1.98021977
118Abnormality of T cell physiology (HP:0011840)1.97200408
119Vasculitis (HP:0002633)1.96658055
120Duplicated collecting system (HP:0000081)1.95669763
121Trigonocephaly (HP:0000243)1.94667360
122Leukocytosis (HP:0001974)1.93561666
123Upper motor neuron abnormality (HP:0002127)1.93427733
124Recurrent bacterial skin infections (HP:0005406)1.93236289
125Limb ataxia (HP:0002070)1.90602926
126Neutropenia (HP:0001875)1.90082400
127Asplenia (HP:0001746)1.88710600
128Stenosis of the external auditory canal (HP:0000402)1.87232583
129Mesangial abnormality (HP:0001966)1.87198239
130Tubular atrophy (HP:0000092)1.85032146
131Lymphoma (HP:0002665)1.84823484
132Colitis (HP:0002583)1.82476326
133Agammaglobulinemia (HP:0004432)1.81697126
134Hypoplastic nipples (HP:0002557)1.81485149
135Scanning speech (HP:0002168)1.79910447
136Diastasis recti (HP:0001540)1.79878149
137Ectopic kidney (HP:0000086)1.78653632
138Neoplasm of the tracheobronchial system (HP:0100552)1.77607766
139Pulmonary fibrosis (HP:0002206)1.75303497
140Autoimmune hemolytic anemia (HP:0001890)1.74939470
141Abnormality of the renal collecting system (HP:0004742)1.73181346
142Stomach cancer (HP:0012126)1.73025618
143Thrombocytosis (HP:0001894)1.71644154
144Increased CSF protein (HP:0002922)1.71642228
145Amaurosis fugax (HP:0100576)1.70427268
146Hypergammaglobulinemia (HP:0010702)1.68733161
147Pulmonary embolism (HP:0002204)1.68296213
148Ureteral duplication (HP:0000073)1.68208082
149Bicuspid aortic valve (HP:0001647)1.67258371
150Atonic seizures (HP:0010819)1.66659293
151Truncal ataxia (HP:0002078)1.65925574
152Abnormal spermatogenesis (HP:0008669)1.65542534
153Male infertility (HP:0003251)1.64941993
154Generalized hypopigmentation of hair (HP:0011358)1.64692032
155Chest pain (HP:0100749)1.63948455
156Tented upper lip vermilion (HP:0010804)1.62401742
157Abnormality of the fingertips (HP:0001211)1.62073446
158Episodic fever (HP:0001954)1.60532925
159Acute necrotizing encephalopathy (HP:0006965)1.59119010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.00532455
2MAP4K15.50060090
3BCR5.29436602
4ITK4.27939942
5TGFBR24.17083917
6ZAP703.30843328
7JAK33.01793249
8PDK32.58354120
9PDK42.58354120
10FRK2.47114529
11PDK22.46257845
12MAP3K112.41943376
13CSK2.19876283
14PIK3CG2.12289158
15TYK22.08346284
16TAOK22.06967904
17RIPK12.04949133
18MAP3K142.04743932
19JAK11.91348235
20NLK1.84553710
21TEC1.79169373
22TAOK31.75572764
23LCK1.72196905
24ADRBK21.67038477
25IKBKE1.66887265
26TESK11.65125613
27SRPK11.62976211
28TYRO31.62247773
29STK101.59756215
30ZAK1.58314627
31TLK11.54573471
32STK381.53848856
33FGFR41.52438586
34CLK11.52089071
35CAMKK21.46488299
36WNK11.41898037
37BTK1.38970525
38MAP3K31.38456553
39EPHB11.34349910
40PINK11.31824679
41FGFR31.29243796
42PRKCH1.25910252
43PDK11.23005544
44IRAK41.17103781
45SYK1.15744214
46PIM21.09901375
47HCK1.09749960
48PAK31.09653315
49PIM11.06817782
50FER1.06508221
51GRK61.05645299
52TBK11.03349881
53RIPK41.00603305
54IKBKB0.95565606
55PRKCQ0.94944698
56CAMKK10.92838466
57TSSK60.92202672
58TESK20.91923450
59ALK0.90907834
60MAP4K20.90496056
61MARK30.89093194
62NUAK10.88036564
63SIK20.87273853
64KDR0.85574071
65KSR10.84787972
66JAK20.83765400
67MAPK130.83005328
68RAF10.78289047
69EIF2AK20.75945325
70PTK60.75734141
71FES0.73976431
72STK110.73557333
73IRAK30.73298164
74PRKD30.70470274
75GRK10.70394148
76LRRK20.68886643
77EPHA30.68704237
78MST40.67774942
79OXSR10.67392100
80PIK3CA0.67093461
81STK390.66271602
82EEF2K0.65801839
83CHUK0.63579187
84TRIB30.62938500
85CSNK1A1L0.61435478
86WNK40.60051338
87GRK70.60031341
88MELK0.59707223
89IRAK10.59210371
90LYN0.58027158
91STK30.57958428
92PTK2B0.57413604
93NTRK20.55999839
94PDGFRB0.55827620
95TAOK10.55543185
96AKT30.53521661
97MAP3K130.52681073
98ICK0.52033869
99DAPK20.51451584
100INSR0.50972488
101FYN0.49418372
102KIT0.48953700
103FGFR10.47613378
104MAP3K10.47580879
105NEK60.47459737
106CASK0.46393670
107CDK120.46327150
108BMPR20.44753832
109PASK0.44022614
110EIF2AK10.43471724
111BLK0.41760272
112MAP3K70.40355994
113RPS6KA40.40133673
114PHKG10.38412802
115PHKG20.38412802
116PDPK10.37996135
117SIK30.37030518
118MAPKAPK20.37004081
119MAP3K50.35516868
120GRK50.35353188
121EIF2AK30.34092773
122NEK20.33780786
123PRKCE0.33099581
124NEK90.32126805
125MUSK0.31870819
126PRKCI0.31696338
127IGF1R0.31220941
128MAP2K30.30989047
129IRAK20.29609530
130STK38L0.29549268
131VRK10.29045813
132CSF1R0.28250446
133FGFR20.26280189
134PRKD20.25709990
135MAP2K60.25684692
136CSNK1A10.24351842
137STK40.24020260
138MARK20.23497341
139PLK30.23314158
140CDK40.23251527
141PNCK0.22786330
142MATK0.22321841
143HIPK20.22118478
144PRKCD0.21515338
145ADRBK10.21356652
146TNK20.21304674
147CCNB10.21175266
148EGFR0.21011728
149PAK60.19671830

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053326.08734743
2Allograft rejection_Homo sapiens_hsa053304.08919509
3Primary immunodeficiency_Homo sapiens_hsa053403.66997391
4Type I diabetes mellitus_Homo sapiens_hsa049403.54247995
5T cell receptor signaling pathway_Homo sapiens_hsa046603.52952625
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.51577938
7Antigen processing and presentation_Homo sapiens_hsa046123.08909413
8Proteasome_Homo sapiens_hsa030503.03514414
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.90885706
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42233894
11Measles_Homo sapiens_hsa051622.13952537
12Autoimmune thyroid disease_Homo sapiens_hsa053202.07919789
13Asthma_Homo sapiens_hsa053102.05784527
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.90437412
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72978652
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.72642595
17Hematopoietic cell lineage_Homo sapiens_hsa046401.65587180
18Linoleic acid metabolism_Homo sapiens_hsa005911.62932302
19Osteoclast differentiation_Homo sapiens_hsa043801.52144447
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.51160945
21Non-homologous end-joining_Homo sapiens_hsa034501.48378572
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47217539
23Leishmaniasis_Homo sapiens_hsa051401.47012822
24Phototransduction_Homo sapiens_hsa047441.42423408
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41108591
26Chemokine signaling pathway_Homo sapiens_hsa040621.40349253
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29943071
28Long-term potentiation_Homo sapiens_hsa047201.28578009
29Collecting duct acid secretion_Homo sapiens_hsa049661.22026989
30B cell receptor signaling pathway_Homo sapiens_hsa046621.18480663
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14264481
32Viral myocarditis_Homo sapiens_hsa054161.08007446
33Nicotine addiction_Homo sapiens_hsa050331.04701513
34Salmonella infection_Homo sapiens_hsa051321.02796369
35Toxoplasmosis_Homo sapiens_hsa051450.99977528
36Rheumatoid arthritis_Homo sapiens_hsa053230.99683715
37Herpes simplex infection_Homo sapiens_hsa051680.97231194
38Nitrogen metabolism_Homo sapiens_hsa009100.96217558
39Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94655957
40TNF signaling pathway_Homo sapiens_hsa046680.93270751
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91006161
42HTLV-I infection_Homo sapiens_hsa051660.89667290
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89077808
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88052516
45Apoptosis_Homo sapiens_hsa042100.84624838
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81922766
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81868934
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79027721
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78881853
50Legionellosis_Homo sapiens_hsa051340.75875760
51Acute myeloid leukemia_Homo sapiens_hsa052210.75611766
52Glutamatergic synapse_Homo sapiens_hsa047240.73988400
53Oxidative phosphorylation_Homo sapiens_hsa001900.73724730
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73569566
55Influenza A_Homo sapiens_hsa051640.72251701
56Dorso-ventral axis formation_Homo sapiens_hsa043200.72172593
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.70639172
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70268319
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70191737
60VEGF signaling pathway_Homo sapiens_hsa043700.68872012
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68793394
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68179577
63Malaria_Homo sapiens_hsa051440.67471805
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67100449
65Ether lipid metabolism_Homo sapiens_hsa005650.66626322
66Fanconi anemia pathway_Homo sapiens_hsa034600.64536622
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63958764
68Shigellosis_Homo sapiens_hsa051310.62180259
69Pentose phosphate pathway_Homo sapiens_hsa000300.58826105
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58534639
71Amphetamine addiction_Homo sapiens_hsa050310.57698655
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57327676
73Hepatitis B_Homo sapiens_hsa051610.57103200
74Salivary secretion_Homo sapiens_hsa049700.56883164
75Inositol phosphate metabolism_Homo sapiens_hsa005620.56798312
76Pancreatic cancer_Homo sapiens_hsa052120.55246403
77Epstein-Barr virus infection_Homo sapiens_hsa051690.54158832
78Long-term depression_Homo sapiens_hsa047300.54111363
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53607192
80Tuberculosis_Homo sapiens_hsa051520.51230303
81MAPK signaling pathway_Homo sapiens_hsa040100.50913935
82African trypanosomiasis_Homo sapiens_hsa051430.49316129
83RNA polymerase_Homo sapiens_hsa030200.48578727
84Endocytosis_Homo sapiens_hsa041440.48047909
85Caffeine metabolism_Homo sapiens_hsa002320.47703092
86Chronic myeloid leukemia_Homo sapiens_hsa052200.46899547
87Gastric acid secretion_Homo sapiens_hsa049710.46129628
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46047409
89Taste transduction_Homo sapiens_hsa047420.45835938
90Fatty acid biosynthesis_Homo sapiens_hsa000610.45486484
91RNA degradation_Homo sapiens_hsa030180.45288856
92Type II diabetes mellitus_Homo sapiens_hsa049300.44688866
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44684793
94Platelet activation_Homo sapiens_hsa046110.44140560
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43341141
96Amoebiasis_Homo sapiens_hsa051460.43209801
97Morphine addiction_Homo sapiens_hsa050320.42893633
98Synaptic vesicle cycle_Homo sapiens_hsa047210.42828827
99Pancreatic secretion_Homo sapiens_hsa049720.42309393
100Staphylococcus aureus infection_Homo sapiens_hsa051500.40852125
101Basal transcription factors_Homo sapiens_hsa030220.40373416
102cAMP signaling pathway_Homo sapiens_hsa040240.39494171
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39218835
104Renin secretion_Homo sapiens_hsa049240.39120322
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38928184
106Circadian entrainment_Homo sapiens_hsa047130.38309747
107Colorectal cancer_Homo sapiens_hsa052100.38189615
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38181052
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37105848
110Prolactin signaling pathway_Homo sapiens_hsa049170.36594035
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.36273283
112Viral carcinogenesis_Homo sapiens_hsa052030.36250455
113mRNA surveillance pathway_Homo sapiens_hsa030150.36093390
114Ovarian steroidogenesis_Homo sapiens_hsa049130.35976532
115N-Glycan biosynthesis_Homo sapiens_hsa005100.34611747
116p53 signaling pathway_Homo sapiens_hsa041150.34451251
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.34397049
118GABAergic synapse_Homo sapiens_hsa047270.34088548
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33847726
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.33509956
121Estrogen signaling pathway_Homo sapiens_hsa049150.33227420
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.32873832
123Protein export_Homo sapiens_hsa030600.31439640
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.31185351
125Calcium signaling pathway_Homo sapiens_hsa040200.30974922
126Spliceosome_Homo sapiens_hsa030400.30488994
127Parkinsons disease_Homo sapiens_hsa050120.29933143
128Selenocompound metabolism_Homo sapiens_hsa004500.29719688
129Glucagon signaling pathway_Homo sapiens_hsa049220.29694815
130Pertussis_Homo sapiens_hsa051330.29611958
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28166627
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.27603634
133Oocyte meiosis_Homo sapiens_hsa041140.27219705
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26766370
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.26463179
136Small cell lung cancer_Homo sapiens_hsa052220.26049882
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22696260
138Regulation of autophagy_Homo sapiens_hsa041400.21570166
139Arachidonic acid metabolism_Homo sapiens_hsa005900.21510280
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21029629
141Sulfur metabolism_Homo sapiens_hsa009200.19871551
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.19194530
143Glycerolipid metabolism_Homo sapiens_hsa005610.18490082
144Arginine and proline metabolism_Homo sapiens_hsa003300.17814977
145Olfactory transduction_Homo sapiens_hsa047400.17708779
146Alzheimers disease_Homo sapiens_hsa050100.16370923
147Circadian rhythm_Homo sapiens_hsa047100.12516571

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