CRTAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)4.71649003
2barbed-end actin filament capping (GO:0051016)4.52722815
3collagen fibril organization (GO:0030199)4.39432469
4extracellular fibril organization (GO:0043206)3.87362803
5protein localization to endosome (GO:0036010)3.86516095
6ribosomal small subunit assembly (GO:0000028)3.80159211
7pinocytosis (GO:0006907)3.75237731
8formation of translation preinitiation complex (GO:0001731)3.74851620
9viral transcription (GO:0019083)3.66059039
10basement membrane organization (GO:0071711)3.63779068
11endodermal cell differentiation (GO:0035987)3.62077597
12cell-substrate junction assembly (GO:0007044)3.60291760
13skin morphogenesis (GO:0043589)3.57843571
14translational termination (GO:0006415)3.57535080
15chondrocyte proliferation (GO:0035988)3.53364254
16keratan sulfate catabolic process (GO:0042340)3.52835759
17bone trabecula formation (GO:0060346)3.52506495
18protein maturation by protein folding (GO:0022417)3.46760755
19adherens junction assembly (GO:0034333)3.46306793
20stress fiber assembly (GO:0043149)3.44822299
21maturation of SSU-rRNA (GO:0030490)3.34278202
22planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30839651
23regulation of early endosome to late endosome transport (GO:2000641)3.30369018
24focal adhesion assembly (GO:0048041)3.30053542
25cell-substrate adherens junction assembly (GO:0007045)3.30053542
26hemidesmosome assembly (GO:0031581)3.29395534
27hyaluronan catabolic process (GO:0030214)3.24986491
28translational elongation (GO:0006414)3.21040991
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17833701
30regulation of SMAD protein import into nucleus (GO:0060390)3.15179358
31pentose-phosphate shunt (GO:0006098)3.12187850
32ribosomal small subunit biogenesis (GO:0042274)3.10592032
33protein targeting to ER (GO:0045047)3.08469971
34collagen metabolic process (GO:0032963)3.08316436
35translational initiation (GO:0006413)3.08251947
36retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.06289519
37cortical actin cytoskeleton organization (GO:0030866)3.04603477
38cotranslational protein targeting to membrane (GO:0006613)3.04008996
39positive regulation of endothelial cell apoptotic process (GO:2000353)3.03027117
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02531805
41positive regulation of SMAD protein import into nucleus (GO:0060391)3.02273961
42Golgi transport vesicle coating (GO:0048200)3.01410652
43COPI coating of Golgi vesicle (GO:0048205)3.01410652
44low-density lipoprotein particle clearance (GO:0034383)2.99474676
45collagen catabolic process (GO:0030574)2.99081725
46regulation of protein heterodimerization activity (GO:0043497)2.98459914
47wound healing, spreading of epidermal cells (GO:0035313)2.95862784
48positive regulation of receptor recycling (GO:0001921)2.94062038
49establishment of protein localization to endoplasmic reticulum (GO:0072599)2.92450495
50protein retention in ER lumen (GO:0006621)2.91888942
51regulation of extracellular matrix disassembly (GO:0010715)2.91505744
52type B pancreatic cell proliferation (GO:0044342)2.90883806
53retina vasculature morphogenesis in camera-type eye (GO:0061299)2.90049736
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89747662
55UV protection (GO:0009650)2.89746711
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88984404
57negative regulation of smooth muscle cell migration (GO:0014912)2.88648595
58protein localization to endoplasmic reticulum (GO:0070972)2.88621720
59dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.87937381
60extracellular matrix assembly (GO:0085029)2.86666298
61regulation of glucose import in response to insulin stimulus (GO:2001273)2.84714892
62cellular response to vitamin (GO:0071295)2.83195154
63multicellular organismal macromolecule metabolic process (GO:0044259)2.82613049
64epithelial cell-cell adhesion (GO:0090136)2.81914956
65apoptotic cell clearance (GO:0043277)2.81437871
66regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.80734085
67kidney mesenchyme development (GO:0072074)2.78738302
68viral life cycle (GO:0019058)2.77814372
69positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76243039
70vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.74789423
71cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.73814440
72adhesion of symbiont to host (GO:0044406)2.73748879
73multicellular organismal catabolic process (GO:0044243)2.72724988
74sequestering of extracellular ligand from receptor (GO:0035581)2.72250686
75muscle cell migration (GO:0014812)2.71193313
76extracellular matrix disassembly (GO:0022617)2.71173137
77cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.70043230
78hypotonic response (GO:0006971)2.68191986
79glucose catabolic process (GO:0006007)2.67668629
80endothelial cell chemotaxis (GO:0035767)2.67634583
81negative regulation of protein localization to plasma membrane (GO:1903077)2.67522048
82regulation of mammary gland epithelial cell proliferation (GO:0033599)2.66903335
83response to laminar fluid shear stress (GO:0034616)2.66540919
84DNA deamination (GO:0045006)2.65734526
85NADPH regeneration (GO:0006740)2.65563020
86multicellular organismal metabolic process (GO:0044236)2.65169919
87cortical cytoskeleton organization (GO:0030865)2.64703213
88negative regulation of chondrocyte differentiation (GO:0032331)2.64342546
89IMP biosynthetic process (GO:0006188)2.64185793
90virion attachment to host cell (GO:0019062)2.63478742
91adhesion of symbiont to host cell (GO:0044650)2.63478742
92glial cell migration (GO:0008347)2.62214297
93cellular protein complex disassembly (GO:0043624)2.62187050
94cellular response to vitamin D (GO:0071305)2.61935397
95* peptidyl-proline hydroxylation (GO:0019511)2.59344646
96positive regulation of osteoblast proliferation (GO:0033690)2.58996679
97embryo implantation (GO:0007566)2.57061502
98membrane raft organization (GO:0031579)2.56614654
99substrate-dependent cell migration (GO:0006929)2.56354534
100negative regulation of fatty acid transport (GO:2000192)2.56236404
101polarized epithelial cell differentiation (GO:0030859)2.56224474
102activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53640525
103ribosome assembly (GO:0042255)2.51506061
104membrane protein ectodomain proteolysis (GO:0006509)2.50514050
105folic acid-containing compound biosynthetic process (GO:0009396)2.49099296
106renal filtration (GO:0097205)2.47572279
107heterochromatin organization (GO:0070828)2.47101263
108metanephric mesenchyme development (GO:0072075)2.45543299
109IMP metabolic process (GO:0046040)2.45387647
110nucleobase biosynthetic process (GO:0046112)2.44717681
111negative regulation of cartilage development (GO:0061037)2.44522784
112mesenchymal-epithelial cell signaling (GO:0060638)2.44090182
113vesicle coating (GO:0006901)2.43718782
114T cell apoptotic process (GO:0070231)2.43558944
115positive regulation of extracellular matrix organization (GO:1903055)2.43424707
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.43415087
117paraxial mesoderm development (GO:0048339)2.43136500
118negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.42970057
119positive regulation of epithelial to mesenchymal transition (GO:0010718)2.42373411
120regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.42098885
121positive regulation of nuclease activity (GO:0032075)2.42070358
122endothelial cell morphogenesis (GO:0001886)2.40640967
123semaphorin-plexin signaling pathway (GO:0071526)2.39810268
124protein targeting to plasma membrane (GO:0072661)2.39456122
125positive regulation of odontogenesis (GO:0042482)2.39183763
126negative regulation of homotypic cell-cell adhesion (GO:0034111)2.39102846
127DNA strand elongation involved in DNA replication (GO:0006271)2.39005898
128Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38388246
129ribonucleoprotein complex biogenesis (GO:0022613)2.38031308
130mitotic nuclear envelope disassembly (GO:0007077)2.37831862
131protein localization to cell surface (GO:0034394)2.37459951
132DNA unwinding involved in DNA replication (GO:0006268)2.36984024
133negative regulation of erythrocyte differentiation (GO:0045647)2.35785980
134ribosomal large subunit biogenesis (GO:0042273)2.35526391
135protein complex disassembly (GO:0043241)2.33352182
136wound healing, spreading of cells (GO:0044319)2.32938238
137establishment of apical/basal cell polarity (GO:0035089)2.32663707
138cell adhesion mediated by integrin (GO:0033627)2.32469848
139protein localization to kinetochore (GO:0034501)2.30797802
140regulation of spindle organization (GO:0090224)2.30671118
141regulation of integrin-mediated signaling pathway (GO:2001044)2.30497276
142regulation of mitotic spindle organization (GO:0060236)2.30362978
143substrate adhesion-dependent cell spreading (GO:0034446)2.29613706
144glomerular basement membrane development (GO:0032836)2.29269560
145maternal placenta development (GO:0001893)2.28111512
146regulation of tight junction assembly (GO:2000810)2.27427943
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.27349165
148anatomical structure regression (GO:0060033)2.24636582
149nuclear envelope disassembly (GO:0051081)2.22982830
150membrane disassembly (GO:0030397)2.22982830
151DNA strand elongation (GO:0022616)2.22872326
152purine nucleobase biosynthetic process (GO:0009113)2.22099324
153DNA replication initiation (GO:0006270)2.21806907
154lymphocyte apoptotic process (GO:0070227)2.21584982
155ribosome biogenesis (GO:0042254)2.21566616
156vascular endothelial growth factor signaling pathway (GO:0038084)2.21329973
157cell migration involved in heart development (GO:0060973)2.19541402
158* protein hydroxylation (GO:0018126)2.19537631
159positive regulation of blood vessel endothelial cell migration (GO:0043536)2.19533927
160regulation of translational fidelity (GO:0006450)2.19473960
161protein targeting to membrane (GO:0006612)2.19033435
162outer ear morphogenesis (GO:0042473)2.18083361
163response to interferon-alpha (GO:0035455)2.16272386
164cellular response to interferon-alpha (GO:0035457)2.15868636
165telomere maintenance via semi-conservative replication (GO:0032201)2.15748166
166fibril organization (GO:0097435)2.15068158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.83947851
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.93579306
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.52891711
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.46593220
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.87866515
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68550349
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.63492802
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52618052
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15250439
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.11747884
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10125717
12* LXR_22292898_ChIP-Seq_THP-1_Human2.07129228
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05583941
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03467969
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90071685
16STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88518596
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.85537102
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84867127
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81834996
20CLOCK_20551151_ChIP-Seq_293T_Human1.80526095
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.78113841
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77469028
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76417506
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75868605
25MYC_22102868_ChIP-Seq_BL_Human1.74490210
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70680265
27XRN2_22483619_ChIP-Seq_HELA_Human1.66495115
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63895143
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61583761
30AR_21909140_ChIP-Seq_LNCAP_Human1.61116189
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60994130
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58663036
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.58367220
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57756413
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55702500
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55398806
37* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54048478
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53618911
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51944899
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51944899
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51944899
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51454596
43VDR_21846776_ChIP-Seq_THP-1_Human1.51111940
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48659833
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48196291
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47833091
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46997421
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43925969
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43876660
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43202109
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39683848
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.39532906
53* ATF3_27146783_Chip-Seq_COLON_Human1.39178940
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38028975
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36718830
56KDM2B_26808549_Chip-Seq_DND41_Human1.35459968
57TFEB_21752829_ChIP-Seq_HELA_Human1.35437416
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34756075
59KDM2B_26808549_Chip-Seq_K562_Human1.34746647
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.34251680
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34142390
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33485659
63TCF7_22412390_ChIP-Seq_EML_Mouse1.31296763
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31131782
65DCP1A_22483619_ChIP-Seq_HELA_Human1.30405759
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30308203
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.29476839
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.29476839
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29096605
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27399901
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26983689
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25738509
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23864670
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22758480
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22181876
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20937969
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.19650777
78TTF2_22483619_ChIP-Seq_HELA_Human1.19033454
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18560462
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16813148
81ZNF263_19887448_ChIP-Seq_K562_Human1.16313344
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.15556322
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15209282
84RACK7_27058665_Chip-Seq_MCF-7_Human1.14663564
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.14632019
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14502210
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14489900
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14185431
89* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13496670
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13107039
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13098917
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13028038
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12690216
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11657271
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11494341
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11432604
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10975654
98GABP_19822575_ChIP-Seq_HepG2_Human1.10565765
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09584147
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08536468
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07970176
102CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07728097
103VDR_24763502_ChIP-Seq_THP-1_Human1.06636887
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06152855
105RXR_22158963_ChIP-Seq_LIVER_Mouse1.06111708
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05841988
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05751291
108HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05224792
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.04801448
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03886950
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03629577
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03264977
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.02599603
114* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02434777
115SA1_27219007_Chip-Seq_ERYTHROID_Human1.01339469
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00953320
117* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00920398
118WT1_19549856_ChIP-ChIP_CCG9911_Human1.00787977
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00354688
120TP53_22127205_ChIP-Seq_IMR90_Human1.00022492
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99439404
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99058264
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98769471
124ELK1_19687146_ChIP-ChIP_HELA_Human0.98608426
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98591627
126VDR_23849224_ChIP-Seq_CD4+_Human0.98424018
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97927355
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97687752
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.97599500
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97539448
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96496825
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96420022
133SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96342818
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96342818
135UBF1/2_26484160_Chip-Seq_HMECs_Human0.96221443
136NCOR1_26117541_ChIP-Seq_K562_Human0.95779996
137SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95439356
138EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94712003
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94386927
140PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93895495
141NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93729929
142CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93442240
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92988021
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92352591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.91438881
2MP0003705_abnormal_hypodermis_morpholog4.00457306
3MP0005275_abnormal_skin_tensile3.92156456
4MP0005503_abnormal_tendon_morphology3.89344546
5MP0003279_aneurysm2.95535397
6MP0005058_abnormal_lysosome_morphology2.65271597
7MP0006054_spinal_hemorrhage2.62655723
8MP0004272_abnormal_basement_membrane2.51085255
9MP0010352_gastrointestinal_tract_polyps2.33503068
10MP0003566_abnormal_cell_adhesion2.28975006
11MP0001958_emphysema2.24740298
12MP0000751_myopathy1.99415435
13MP0005023_abnormal_wound_healing1.97031353
14MP0009384_cardiac_valve_regurgitation1.90398765
15MP0004858_abnormal_nervous_system1.83821232
16MP0005508_abnormal_skeleton_morphology1.80924824
17MP0005623_abnormal_meninges_morphology1.75720596
18MP0003191_abnormal_cellular_cholesterol1.75446747
19MP0005171_absent_coat_pigmentation1.71118961
20MP0002060_abnormal_skin_morphology1.69734348
21MP0005257_abnormal_intraocular_pressure1.61372812
22MP0001542_abnormal_bone_strength1.60809692
23MP0010030_abnormal_orbit_morphology1.56691264
24MP0004957_abnormal_blastocyst_morpholog1.55865662
25MP0003693_abnormal_embryo_hatching1.55765884
26MP0004233_abnormal_muscle_weight1.51084200
27MP0005670_abnormal_white_adipose1.45367030
28MP0005666_abnormal_adipose_tissue1.40681521
29MP0000003_abnormal_adipose_tissue1.37480994
30MP0005375_adipose_tissue_phenotype1.35179672
31MP0002933_joint_inflammation1.34905390
32MP0003950_abnormal_plasma_membrane1.34757693
33MP0009840_abnormal_foam_cell1.29805961
34MP0008260_abnormal_autophagy1.29344693
35MP0005409_darkened_coat_color1.28611455
36MP0002396_abnormal_hematopoietic_system1.28262846
37MP0003941_abnormal_skin_development1.27555363
38MP0002877_abnormal_melanocyte_morpholog1.26652449
39MP0001243_abnormal_dermal_layer1.23810846
40MP0010368_abnormal_lymphatic_system1.23429794
41MP0004808_abnormal_hematopoietic_stem1.23090930
42MP0002282_abnormal_trachea_morphology1.22063498
43MP0005390_skeleton_phenotype1.21814126
44MP0001348_abnormal_lacrimal_gland1.20204653
45MP0005076_abnormal_cell_differentiation1.19710485
46MP0000750_abnormal_muscle_regeneration1.19657038
47MP0009250_abnormal_appendicular_skeleto1.19329414
48MP0008007_abnormal_cellular_replicative1.18985923
49MP0000733_abnormal_muscle_development1.18734629
50MP0000013_abnormal_adipose_tissue1.14100914
51MP0006138_congestive_heart_failure1.13563286
52MP0003091_abnormal_cell_migration1.13368236
53MP0005451_abnormal_body_composition1.13028960
54MP0003453_abnormal_keratinocyte_physiol1.12424076
55MP0003123_paternal_imprinting1.11954048
56MP0000759_abnormal_skeletal_muscle1.11754818
57MP0003300_gastrointestinal_ulcer1.08136973
58MP0002108_abnormal_muscle_morphology1.08090249
59MP0009278_abnormal_bone_marrow1.07435047
60MP0004185_abnormal_adipocyte_glucose1.07228481
61MP0005165_increased_susceptibility_to1.07149079
62MP0000767_abnormal_smooth_muscle1.05899057
63MP0003567_abnormal_fetal_cardiomyocyte1.05117617
64MP0003111_abnormal_nucleus_morphology1.04699049
65* MP0002896_abnormal_bone_mineralization1.03878301
66MP0000858_altered_metastatic_potential1.03416713
67* MP0000163_abnormal_cartilage_morphology1.02574451
68MP0009053_abnormal_anal_canal1.01618646
69MP0002932_abnormal_joint_morphology1.00480019
70MP0002796_impaired_skin_barrier1.00308974
71MP0003077_abnormal_cell_cycle1.00212972
72MP0009780_abnormal_chondrocyte_physiolo0.99642782
73MP0000428_abnormal_craniofacial_morphol0.99428177
74MP0003283_abnormal_digestive_organ0.98530103
75MP0001661_extended_life_span0.97911287
76MP0004087_abnormal_muscle_fiber0.97267597
77* MP0002115_abnormal_skeleton_extremities0.97134810
78MP0003942_abnormal_urinary_system0.95753614
79* MP0002113_abnormal_skeleton_development0.95509690
80MP0010307_abnormal_tumor_latency0.95225647
81MP0003385_abnormal_body_wall0.94981946
82MP0000762_abnormal_tongue_morphology0.94885496
83MP0002295_abnormal_pulmonary_circulatio0.93865573
84MP0001533_abnormal_skeleton_physiology0.93177988
85MP0005595_abnormal_vascular_smooth0.92192835
86MP0000350_abnormal_cell_proliferation0.91912522
87* MP0004197_abnormal_fetal_growth/weight/0.91669588
88MP0000534_abnormal_ureter_morphology0.90634486
89MP0005397_hematopoietic_system_phenotyp0.90627810
90MP0001545_abnormal_hematopoietic_system0.90627810
91MP0000490_abnormal_crypts_of0.90565598
92MP0005408_hypopigmentation0.89983055
93MP0003448_altered_tumor_morphology0.89833397
94MP0002086_abnormal_extraembryonic_tissu0.89645872
95MP0001915_intracranial_hemorrhage0.89338637
96MP0005197_abnormal_uvea_morphology0.89184458
97MP0000343_altered_response_to0.89182428
98MP0004134_abnormal_chest_morphology0.89150542
99MP0000747_muscle_weakness0.88686504
100* MP0002998_abnormal_bone_remodeling0.88418978
101MP0002089_abnormal_postnatal_growth/wei0.88350581
102MP0004084_abnormal_cardiac_muscle0.87972650
103MP0008932_abnormal_embryonic_tissue0.87638238
104MP0002111_abnormal_tail_morphology0.86327726
105MP0001730_embryonic_growth_arrest0.85253469
106MP0005164_abnormal_response_to0.85130708
107MP0009333_abnormal_splenocyte_physiolog0.83533091
108MP0003984_embryonic_growth_retardation0.82608105
109MP0002088_abnormal_embryonic_growth/wei0.81991009
110MP0005330_cardiomyopathy0.81311842
111MP0001697_abnormal_embryo_size0.80573889
112MP0001614_abnormal_blood_vessel0.79860363
113* MP0003795_abnormal_bone_structure0.79717207
114MP0001849_ear_inflammation0.79499005
115MP0005380_embryogenesis_phenotype0.78688859
116MP0001672_abnormal_embryogenesis/_devel0.78688859
117MP0002249_abnormal_larynx_morphology0.78600773
118MP0001299_abnormal_eye_distance/0.78268970
119MP0003115_abnormal_respiratory_system0.77826565
120MP0010630_abnormal_cardiac_muscle0.77166868
121MP0002084_abnormal_developmental_patter0.77007082
122MP0000049_abnormal_middle_ear0.76885226
123MP0003828_pulmonary_edema0.76546574
124MP0005621_abnormal_cell_physiology0.76022165
125MP0002971_abnormal_brown_adipose0.75953224
126MP0000537_abnormal_urethra_morphology0.74817294
127MP0000516_abnormal_urinary_system0.74797537
128MP0005367_renal/urinary_system_phenotyp0.74797537
129MP0002128_abnormal_blood_circulation0.74504301
130MP0002085_abnormal_embryonic_tissue0.74165211
131MP0000432_abnormal_head_morphology0.73767844
132MP0003329_amyloid_beta_deposits0.73656842
133MP0002080_prenatal_lethality0.73624417
134MP0000749_muscle_degeneration0.73619368
135MP0003075_altered_response_to0.73508626
136MP0003172_abnormal_lysosome_physiology0.72793153
137MP0002925_abnormal_cardiovascular_devel0.71625009
138MP0005193_abnormal_anterior_eye0.70670321
139MP0002109_abnormal_limb_morphology0.69297146
140MP0000467_abnormal_esophagus_morphology0.69240465
141MP0001879_abnormal_lymphatic_vessel0.69228482
142MP0005501_abnormal_skin_physiology0.68449600
143MP0001175_abnormal_lung_morphology0.68351085
144MP0003935_abnormal_craniofacial_develop0.66357241
145MP0000681_abnormal_thyroid_gland0.66133327
146MP0010234_abnormal_vibrissa_follicle0.66025474
147MP0002269_muscular_atrophy0.65721017
148MP0001851_eye_inflammation0.62895749

Predicted human phenotypes

RankGene SetZ-score
1* Protrusio acetabuli (HP:0003179)7.55327010
2Premature rupture of membranes (HP:0001788)6.68289515
3Ankle contracture (HP:0006466)4.87205500
4Cervical subluxation (HP:0003308)4.26580690
5Soft skin (HP:0000977)4.00800906
6Shallow orbits (HP:0000586)3.87133048
7Aortic dissection (HP:0002647)3.78980014
8Peritonitis (HP:0002586)3.71480551
9Cerebral aneurysm (HP:0004944)3.56249259
10Atrophic scars (HP:0001075)3.47520671
11Biconcave vertebral bodies (HP:0004586)3.45596879
12Neonatal short-limb short stature (HP:0008921)3.33202740
13Genu recurvatum (HP:0002816)3.24101730
14Aortic aneurysm (HP:0004942)3.17880001
15Abnormality of dentin (HP:0010299)3.17592189
16Bladder diverticulum (HP:0000015)3.16819648
17* Vertebral compression fractures (HP:0002953)3.12441977
18Fragile skin (HP:0001030)3.11066822
19Dilatation of the ascending aorta (HP:0005111)3.05499361
20Broad metatarsal (HP:0001783)3.03356999
21Selective tooth agenesis (HP:0001592)3.00741036
22Spinal rigidity (HP:0003306)2.91096735
23* Blue sclerae (HP:0000592)2.89982275
24Increased connective tissue (HP:0009025)2.81412414
25Type 1 muscle fiber predominance (HP:0003803)2.75937679
26* Wormian bones (HP:0002645)2.73912603
27Follicular hyperkeratosis (HP:0007502)2.70762984
28Wrist flexion contracture (HP:0001239)2.69975550
29Abnormality of skeletal muscle fiber size (HP:0012084)2.67267872
30* Abnormality of the acetabulum (HP:0003170)2.61543277
31Hyperacusis (HP:0010780)2.49834493
32Achilles tendon contracture (HP:0001771)2.48653567
33Mitral valve prolapse (HP:0001634)2.47537205
34Ulnar bowing (HP:0003031)2.46170609
35Radial bowing (HP:0002986)2.42602601
36Distal lower limb muscle weakness (HP:0009053)2.37491113
37Abnormality of glycolipid metabolism (HP:0010969)2.36054989
38Abnormality of liposaccharide metabolism (HP:0010968)2.36054989
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.36054989
40Beaking of vertebral bodies (HP:0004568)2.35534067
41Bowel diverticulosis (HP:0005222)2.33446242
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.29347426
43Osteolytic defects of the hand bones (HP:0009699)2.29347426
44Platyspondyly (HP:0000926)2.28455033
45Joint stiffness (HP:0001387)2.27415373
46Elbow flexion contracture (HP:0002987)2.26739542
47Thin bony cortex (HP:0002753)2.20302596
48Distal lower limb amyotrophy (HP:0008944)2.19456818
49Abnormality of the Achilles tendon (HP:0005109)2.17298731
50Abnormality of the peritoneum (HP:0002585)2.16423991
51Dysostosis multiplex (HP:0000943)2.13449405
52Bowed forearm bones (HP:0003956)2.12493286
53Bowing of the arm (HP:0006488)2.12493286
54* Coxa vara (HP:0002812)2.12226680
55Slender long bone (HP:0003100)2.12102586
56Slender build (HP:0001533)2.11817687
57Back pain (HP:0003418)2.10196357
58Trismus (HP:0000211)2.10111893
59Disproportionate tall stature (HP:0001519)2.10077512
60Nonimmune hydrops fetalis (HP:0001790)2.08080862
61Mesomelia (HP:0003027)2.07941395
62Metaphyseal cupping (HP:0003021)2.06361065
63Generalized amyotrophy (HP:0003700)2.05459746
64Natal tooth (HP:0000695)2.05416049
65Abnormality of the calcaneus (HP:0008364)2.05299307
66Hyperextensible skin (HP:0000974)2.04493884
67* Abnormal delivery (HP:0001787)2.03806689
68Abnormality of the distal phalanges of the toes (HP:0010182)2.03178588
69Aneurysm (HP:0002617)1.99869870
70Centrally nucleated skeletal muscle fibers (HP:0003687)1.99480682
71Cupped ribs (HP:0000887)1.98935808
72Osteoarthritis (HP:0002758)1.98576003
73Nuclear cataract (HP:0100018)1.95790437
74Broad face (HP:0000283)1.94765547
75Mitral stenosis (HP:0001718)1.94611733
76Ectopia lentis (HP:0001083)1.92210363
77Spinal cord compression (HP:0002176)1.90788809
78Joint laxity (HP:0001388)1.90659269
79Myocardial infarction (HP:0001658)1.89992274
80Vascular tortuosity (HP:0004948)1.88382893
81Mucopolysacchariduria (HP:0008155)1.87949251
82Urinary glycosaminoglycan excretion (HP:0003541)1.87949251
83* Abnormality of skull ossification (HP:0002703)1.87753931
84Reduced subcutaneous adipose tissue (HP:0003758)1.87355137
85Deviation of the hallux (HP:0010051)1.85957433
86Mildly elevated creatine phosphokinase (HP:0008180)1.85489951
87* Decreased skull ossification (HP:0004331)1.83834299
88Mild short stature (HP:0003502)1.83213988
89Aortic regurgitation (HP:0001659)1.81376208
90Spondylolisthesis (HP:0003302)1.81208144
91* Delayed cranial suture closure (HP:0000270)1.80601233
92Hallux valgus (HP:0001822)1.80569919
93Thoracolumbar scoliosis (HP:0002944)1.80281745
94Hypoplasia of the iris (HP:0007676)1.80055451
95Mitral regurgitation (HP:0001653)1.79971816
96Venous abnormality (HP:0002624)1.79167739
97Amyloidosis (HP:0011034)1.78981928
98Thrombocytosis (HP:0001894)1.78053861
99Epiphyseal dysplasia (HP:0002656)1.77827457
100Abnormality of polysaccharide metabolism (HP:0011012)1.75773017
101Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75773017
102Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75773017
103Inguinal hernia (HP:0000023)1.75707144
104Abnormal cartilage morphology (HP:0002763)1.75379706
105Asymmetry of the thorax (HP:0001555)1.74861935
106Knee flexion contracture (HP:0006380)1.74829099
107Abnormality of the umbilical cord (HP:0010881)1.74453519
108Short nail (HP:0001799)1.74295510
109Asymmetric septal hypertrophy (HP:0001670)1.74092054
110Insomnia (HP:0100785)1.73557623
111Broad long bones (HP:0005622)1.73285983
112Hand muscle atrophy (HP:0009130)1.72162077
113Syringomyelia (HP:0003396)1.71927106
114Spinal cord lesions (HP:0100561)1.71927106
115Distal upper limb amyotrophy (HP:0007149)1.71903678
116Upper limb amyotrophy (HP:0009129)1.71903678
117Flat acetabular roof (HP:0003180)1.69571125
118Abnormality of complement system (HP:0005339)1.69255645
119Camptodactyly of toe (HP:0001836)1.69069747
120Interstitial pulmonary disease (HP:0006530)1.68720708
121Abnormal ossification of hand bones (HP:0005921)1.68576977
122Tibial bowing (HP:0002982)1.68491918
123Deformed tarsal bones (HP:0008119)1.67302489
124Abnormality of carpal bone ossification (HP:0006257)1.66870348
125Absent frontal sinuses (HP:0002688)1.66286691
126Long toe (HP:0010511)1.66164544
127Axonal loss (HP:0003447)1.65954073
128Premature skin wrinkling (HP:0100678)1.65748842
129Increased variability in muscle fiber diameter (HP:0003557)1.65484388
130Hip contracture (HP:0003273)1.65453723
131Acanthosis nigricans (HP:0000956)1.65420374
132Hypoplastic ischia (HP:0003175)1.64580677
133Multiple enchondromatosis (HP:0005701)1.64307971
134Cerebral inclusion bodies (HP:0100314)1.63986219
135Missing ribs (HP:0000921)1.63741990
136Calcaneovalgus deformity (HP:0001848)1.62834147
137Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.62750094
138Vertebral hypoplasia (HP:0008417)1.62750094
139Overgrowth (HP:0001548)1.62103863
140Abnormal vertebral ossification (HP:0100569)1.62053235
141Arterial tortuosity (HP:0005116)1.61900825
142Rectal prolapse (HP:0002035)1.61231261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.68682552
2ERN13.12417798
3DDR23.09675845
4NME23.00935789
5PKN22.95960216
6IRAK32.39288447
7WEE12.38007054
8PIM22.37286229
9PRPF4B2.26261296
10TTN2.14810006
11RPS6KA42.07512059
12SMG12.07159882
13ICK2.02101193
14NTRK11.94238585
15BUB11.92613628
16PAK41.90801433
17EEF2K1.90619775
18LATS21.90160350
19PDGFRA1.79052834
20EPHA21.76985399
21FLT31.72898098
22TGFBR11.70769331
23RPS6KB21.69221475
24LRRK21.68641522
25MAPKAPK31.66204415
26BRSK21.61728968
27ARAF1.49506995
28EPHB21.49362417
29MAP3K31.44404599
30TGFBR21.43669681
31KDR1.40554462
32PAK21.40290723
33NEK21.39900672
34LATS11.37118802
35CDK71.35369710
36EIF2AK11.29882681
37MAP2K31.26740007
38SCYL21.26301061
39LMTK21.25919753
40SIK11.22475374
41TESK11.21384915
42NEK11.16430611
43TESK21.14085221
44EPHB11.12613133
45STK101.11764499
46STK31.09301180
47BCKDK1.09013942
48MAP3K81.08463867
49PRKD21.06542608
50DYRK31.03809500
51ACVR1B1.01029376
52BMX0.98396812
53MET0.98315374
54TRPM70.97840524
55MAP3K100.97357857
56RIPK10.95953001
57CDC42BPA0.95785301
58PDGFRB0.95472910
59MAP3K110.94648827
60FGFR40.94056990
61MAP3K60.93954731
62ILK0.93861135
63KSR20.93277722
64CDK120.91542148
65KIT0.90831137
66ERBB40.90287229
67MAP3K130.90076180
68PTK20.88642610
69PASK0.87411692
70TTK0.86765407
71PTK60.86582460
72CDK60.85164442
73MTOR0.84358421
74NEK90.80883402
75CDK40.80083259
76TAOK20.79839858
77STK380.77544916
78EIF2AK30.76981974
79PIM10.76753473
80PAK10.75367939
81AURKB0.72441712
82PDPK10.72137938
83MOS0.71579774
84JAK30.70803761
85CDC70.70701343
86RPS6KA20.70490837
87PLK10.69996883
88MYLK0.69871418
89EPHA30.68607174
90PRKG20.64666250
91FGFR10.60405799
92BRAF0.60389153
93DYRK1B0.59202114
94CLK10.56776389
95ROCK20.54901957
96PRKD30.54626457
97CAMKK20.53785421
98MATK0.53588527
99PDK20.53507660
100GSK3A0.53164900
101TIE10.52143021
102MAPK70.51507454
103LIMK10.50974272
104TYK20.50936529
105FER0.50309881
106MAP3K10.50053370
107TAOK10.48749441
108MARK20.47111359
109ZAP700.46713437
110STK38L0.45870016
111AURKA0.45357739
112CSF1R0.44709224
113PAK60.44373270
114RET0.44149439
115PIK3CG0.43731920
116ATR0.43351202
117MAPKAPK20.42752611
118CDK80.42342161
119TBK10.41799549
120PRKD10.41385802
121MAPK110.41314827
122IRAK20.40369675
123MKNK10.39400613
124ABL20.39106972
125VRK20.38497290
126DAPK30.37274479
127RPS6KC10.36169797
128RPS6KL10.36169797
129BRSK10.36096971
130MST1R0.36023076
131DMPK0.35535602
132AKT20.34769132
133HIPK20.33579364
134BTK0.33509424
135MELK0.33371334
136STK240.33306314
137RPS6KA60.32979321
138PBK0.32701610
139CAMK2G0.32246308
140MAP2K10.31284274
141MAP2K20.31275459
142CHEK20.30049025

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.19294206
2DNA replication_Homo sapiens_hsa030303.01810366
3ECM-receptor interaction_Homo sapiens_hsa045122.83820666
4Mismatch repair_Homo sapiens_hsa034302.22063645
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.15694200
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08304414
7p53 signaling pathway_Homo sapiens_hsa041151.97848550
8RNA transport_Homo sapiens_hsa030131.88560802
9Focal adhesion_Homo sapiens_hsa045101.85503583
10One carbon pool by folate_Homo sapiens_hsa006701.81909763
11Cell cycle_Homo sapiens_hsa041101.78421823
12Base excision repair_Homo sapiens_hsa034101.75195774
13Small cell lung cancer_Homo sapiens_hsa052221.73980875
14Proteasome_Homo sapiens_hsa030501.73651246
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73376919
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71860544
17Spliceosome_Homo sapiens_hsa030401.67051759
18Protein digestion and absorption_Homo sapiens_hsa049741.64241298
19Prion diseases_Homo sapiens_hsa050201.54134470
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51978722
21Bladder cancer_Homo sapiens_hsa052191.51241700
22Nucleotide excision repair_Homo sapiens_hsa034201.49207988
23TGF-beta signaling pathway_Homo sapiens_hsa043501.45589785
24Other glycan degradation_Homo sapiens_hsa005111.43445950
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42869891
26Proteoglycans in cancer_Homo sapiens_hsa052051.42560096
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.39614202
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39319966
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.36528521
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34302952
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33765725
32Fructose and mannose metabolism_Homo sapiens_hsa000511.31178627
33RNA polymerase_Homo sapiens_hsa030201.30416011
34Pyrimidine metabolism_Homo sapiens_hsa002401.26867045
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23659674
36MicroRNAs in cancer_Homo sapiens_hsa052061.22088417
37Amoebiasis_Homo sapiens_hsa051461.21789270
38Malaria_Homo sapiens_hsa051441.20881759
39Adherens junction_Homo sapiens_hsa045201.17641531
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17494161
41Hippo signaling pathway_Homo sapiens_hsa043901.16934949
42Homologous recombination_Homo sapiens_hsa034401.11152630
43HTLV-I infection_Homo sapiens_hsa051661.08810845
44Renal cell carcinoma_Homo sapiens_hsa052111.07594747
45Shigellosis_Homo sapiens_hsa051311.07273021
46Chronic myeloid leukemia_Homo sapiens_hsa052201.07195882
47N-Glycan biosynthesis_Homo sapiens_hsa005101.05931594
48Non-small cell lung cancer_Homo sapiens_hsa052231.05199180
49Glioma_Homo sapiens_hsa052141.01223087
50Antigen processing and presentation_Homo sapiens_hsa046121.01162273
51Sulfur relay system_Homo sapiens_hsa041221.00009842
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99430604
53Viral carcinogenesis_Homo sapiens_hsa052030.99036847
54Basal cell carcinoma_Homo sapiens_hsa052170.98772389
55VEGF signaling pathway_Homo sapiens_hsa043700.98724854
56Folate biosynthesis_Homo sapiens_hsa007900.98249300
57Vibrio cholerae infection_Homo sapiens_hsa051100.97299056
58Insulin signaling pathway_Homo sapiens_hsa049100.95258705
59Endometrial cancer_Homo sapiens_hsa052130.94501252
60Thyroid cancer_Homo sapiens_hsa052160.94436174
61Apoptosis_Homo sapiens_hsa042100.92777280
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.90807535
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90600839
64AMPK signaling pathway_Homo sapiens_hsa041520.88218575
65Galactose metabolism_Homo sapiens_hsa000520.87023037
66Legionellosis_Homo sapiens_hsa051340.86603686
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.85427391
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.84887090
69Endocytosis_Homo sapiens_hsa041440.84620681
70Viral myocarditis_Homo sapiens_hsa054160.84416821
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83975230
72HIF-1 signaling pathway_Homo sapiens_hsa040660.82358377
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81320617
74Hedgehog signaling pathway_Homo sapiens_hsa043400.81247062
75Renin-angiotensin system_Homo sapiens_hsa046140.81072211
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.80692729
77Pathways in cancer_Homo sapiens_hsa052000.80413625
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80181264
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79741805
80Epstein-Barr virus infection_Homo sapiens_hsa051690.79594283
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.79314253
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79072371
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77549939
84Lysosome_Homo sapiens_hsa041420.74852232
85Melanoma_Homo sapiens_hsa052180.72648037
86Hepatitis B_Homo sapiens_hsa051610.72172436
87RNA degradation_Homo sapiens_hsa030180.71584240
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71392210
89Herpes simplex infection_Homo sapiens_hsa051680.70353698
90Salmonella infection_Homo sapiens_hsa051320.69034963
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.68596720
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68093124
93Toxoplasmosis_Homo sapiens_hsa051450.67919021
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66790071
95Notch signaling pathway_Homo sapiens_hsa043300.66658412
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66370356
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66062861
98Pertussis_Homo sapiens_hsa051330.65769260
99Acute myeloid leukemia_Homo sapiens_hsa052210.65749230
100Platelet activation_Homo sapiens_hsa046110.64427989
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64313633
102Glutathione metabolism_Homo sapiens_hsa004800.64243541
103Pentose phosphate pathway_Homo sapiens_hsa000300.64048542
104Melanogenesis_Homo sapiens_hsa049160.63118067
105ErbB signaling pathway_Homo sapiens_hsa040120.62866315
106Osteoclast differentiation_Homo sapiens_hsa043800.60702289
107Selenocompound metabolism_Homo sapiens_hsa004500.60429667
108Insulin resistance_Homo sapiens_hsa049310.59285373
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59097517
110Tyrosine metabolism_Homo sapiens_hsa003500.58156337
111Biosynthesis of amino acids_Homo sapiens_hsa012300.57712503
112Estrogen signaling pathway_Homo sapiens_hsa049150.57075947
113Pancreatic cancer_Homo sapiens_hsa052120.56811856
114PPAR signaling pathway_Homo sapiens_hsa033200.56476410
115Prostate cancer_Homo sapiens_hsa052150.56348990
116Phenylalanine metabolism_Homo sapiens_hsa003600.55746005
117Phagosome_Homo sapiens_hsa041450.53945025
118TNF signaling pathway_Homo sapiens_hsa046680.53450612
119Colorectal cancer_Homo sapiens_hsa052100.53385784
120Complement and coagulation cascades_Homo sapiens_hsa046100.51739404
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51369049
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50996200
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50929338
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.50611261
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49886346
126GnRH signaling pathway_Homo sapiens_hsa049120.49849578
127Leishmaniasis_Homo sapiens_hsa051400.48927414
128Rap1 signaling pathway_Homo sapiens_hsa040150.48730420
129Dilated cardiomyopathy_Homo sapiens_hsa054140.48108998
130Carbon metabolism_Homo sapiens_hsa012000.47983453
131Arachidonic acid metabolism_Homo sapiens_hsa005900.47748125
132mTOR signaling pathway_Homo sapiens_hsa041500.46846883
133Gap junction_Homo sapiens_hsa045400.46772664
134Lysine degradation_Homo sapiens_hsa003100.45784575
135Wnt signaling pathway_Homo sapiens_hsa043100.45530225
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44576030
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.42280858
138Fanconi anemia pathway_Homo sapiens_hsa034600.41038440
139Measles_Homo sapiens_hsa051620.40762773
140Purine metabolism_Homo sapiens_hsa002300.39985042
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39669876
142Tight junction_Homo sapiens_hsa045300.37728172

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