CRTC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.48346932
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.42773256
3locomotory exploration behavior (GO:0035641)6.20561816
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.96879560
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.82269455
6vocalization behavior (GO:0071625)5.44622167
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.42753817
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.39554590
9cerebellar granule cell differentiation (GO:0021707)5.17645414
10synaptic vesicle exocytosis (GO:0016079)5.15812733
11regulation of glutamate receptor signaling pathway (GO:1900449)5.11483774
12regulation of synapse structural plasticity (GO:0051823)4.96206576
13glutamate secretion (GO:0014047)4.88420706
14regulation of synaptic vesicle exocytosis (GO:2000300)4.84045782
15regulation of neuronal synaptic plasticity (GO:0048168)4.83723723
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.71837725
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.70853602
18exploration behavior (GO:0035640)4.60194126
19protein localization to synapse (GO:0035418)4.44609061
20dendritic spine morphogenesis (GO:0060997)4.43901497
21synaptic transmission, glutamatergic (GO:0035249)4.38895013
22regulation of synaptic vesicle transport (GO:1902803)4.36662562
23neurotransmitter secretion (GO:0007269)4.36443898
24L-amino acid import (GO:0043092)4.34318925
25layer formation in cerebral cortex (GO:0021819)4.26622362
26neuronal action potential propagation (GO:0019227)4.25622004
27neurotransmitter-gated ion channel clustering (GO:0072578)4.22603308
28sodium ion export (GO:0071436)4.19112787
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.18988513
30cellular potassium ion homeostasis (GO:0030007)4.16499762
31long-term memory (GO:0007616)4.14252997
32positive regulation of synapse maturation (GO:0090129)4.06790431
33gamma-aminobutyric acid transport (GO:0015812)4.05046042
34glutamate receptor signaling pathway (GO:0007215)4.00043848
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.99118282
36positive regulation of membrane potential (GO:0045838)3.98894628
37amino acid import (GO:0043090)3.91847165
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91825923
39cell migration in hindbrain (GO:0021535)3.90591958
40neuron-neuron synaptic transmission (GO:0007270)3.89312384
41neuromuscular process controlling balance (GO:0050885)3.78651211
42regulation of dendritic spine morphogenesis (GO:0061001)3.77340591
43auditory behavior (GO:0031223)3.72546651
44regulation of synaptic plasticity (GO:0048167)3.70529543
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69353750
46axon ensheathment in central nervous system (GO:0032291)3.67126698
47central nervous system myelination (GO:0022010)3.67126698
48regulation of postsynaptic membrane potential (GO:0060078)3.66198956
49cell communication by electrical coupling (GO:0010644)3.65981530
50proline transport (GO:0015824)3.61502073
51neuron cell-cell adhesion (GO:0007158)3.60547319
52potassium ion homeostasis (GO:0055075)3.59780519
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59726326
54positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.59089354
55prepulse inhibition (GO:0060134)3.54034004
56cerebellar Purkinje cell differentiation (GO:0021702)3.53446604
57activation of protein kinase A activity (GO:0034199)3.51010101
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48139010
59response to auditory stimulus (GO:0010996)3.45356792
60synaptic vesicle endocytosis (GO:0048488)3.44697356
61G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.40844318
62neuromuscular process controlling posture (GO:0050884)3.39588308
63regulation of ARF protein signal transduction (GO:0032012)3.39428471
64regulation of voltage-gated calcium channel activity (GO:1901385)3.38524691
65neurotransmitter transport (GO:0006836)3.37509818
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37062719
67regulation of neurotransmitter secretion (GO:0046928)3.36703515
68dendritic spine organization (GO:0097061)3.36535846
69cytoskeletal anchoring at plasma membrane (GO:0007016)3.35979291
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.34866822
71cell differentiation in hindbrain (GO:0021533)3.34480887
72glycine transport (GO:0015816)3.32021986
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.31869050
74membrane depolarization during action potential (GO:0086010)3.29087856
75dendrite morphogenesis (GO:0048813)3.27026835
76transmission of nerve impulse (GO:0019226)3.25896612
77response to pheromone (GO:0019236)3.25450903
78long-term synaptic potentiation (GO:0060291)3.25445873
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23501994
80regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23201302
81neuron recognition (GO:0008038)3.22402602
82positive regulation of neurotransmitter secretion (GO:0001956)3.22335240
83neuronal ion channel clustering (GO:0045161)3.20920519
84positive regulation of neurotransmitter transport (GO:0051590)3.20351497
85positive regulation of dendritic spine development (GO:0060999)3.18506083
86membrane depolarization (GO:0051899)3.17875998
87regulation of neurotransmitter levels (GO:0001505)3.15292084
88regulation of synapse maturation (GO:0090128)3.14521272
89regulation of neurotransmitter transport (GO:0051588)3.14424168
90regulation of vesicle fusion (GO:0031338)3.13894172
91cerebellar Purkinje cell layer development (GO:0021680)3.12207450
92gamma-aminobutyric acid signaling pathway (GO:0007214)3.11072622
93innervation (GO:0060384)3.10735542
94regulation of dendritic spine development (GO:0060998)3.08273205
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07696712
96cellular sodium ion homeostasis (GO:0006883)3.06869833
97behavioral defense response (GO:0002209)3.06435448
98behavioral fear response (GO:0001662)3.06435448
99negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06393770
100positive regulation of dendritic spine morphogenesis (GO:0061003)3.04415136
101axonal fasciculation (GO:0007413)3.04209901
102establishment of mitochondrion localization (GO:0051654)3.04097650
103neuromuscular process (GO:0050905)3.04059182
104chemosensory behavior (GO:0007635)3.00968417
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.00368977
106learning (GO:0007612)2.99663734
107positive regulation of dendrite development (GO:1900006)2.99303865
108potassium ion import (GO:0010107)2.98933400
109dopamine receptor signaling pathway (GO:0007212)2.98218730
110positive regulation of synaptic transmission (GO:0050806)2.98166208
111postsynaptic membrane organization (GO:0001941)2.96117221
112regulation of synaptic transmission (GO:0050804)2.95118876
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93737033
114visual learning (GO:0008542)2.93616479
115mechanosensory behavior (GO:0007638)2.92661400
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90218724
117synaptic vesicle transport (GO:0048489)2.89297181
118establishment of synaptic vesicle localization (GO:0097480)2.89297181
119peptidyl-tyrosine autophosphorylation (GO:0038083)2.81318856
120regulation of exocytosis (GO:0017157)2.78265569
121acidic amino acid transport (GO:0015800)2.77948995
122regulation of respiratory gaseous exchange (GO:0043576)2.75844187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96177848
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.12310196
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04534000
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02631868
5DROSHA_22980978_ChIP-Seq_HELA_Human3.01677843
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98160835
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82032210
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82032210
9REST_21632747_ChIP-Seq_MESCs_Mouse2.78121352
10GBX2_23144817_ChIP-Seq_PC3_Human2.76624526
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75099633
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.66506807
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.57588207
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57126008
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56748620
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.54651230
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48962232
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.45979061
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44368260
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.42346109
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39893312
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38780248
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38665164
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.34448949
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.30433837
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.13850997
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00945021
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81817829
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78724447
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.77305583
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63547306
32* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60466876
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58721103
34AR_21572438_ChIP-Seq_LNCaP_Human1.57606967
35* KDM2B_26808549_Chip-Seq_K562_Human1.57010395
36* P68_20966046_ChIP-Seq_HELA_Human1.51869545
37* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51465816
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48098753
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.47588881
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47109700
41* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45134602
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.44073283
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43094903
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41601736
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39864703
46TCF7_22412390_ChIP-Seq_EML_Mouse1.38150351
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33340218
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33076923
49* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31675259
50CREB1_26743006_Chip-Seq_LNCaP_Human1.30328122
51SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29353200
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29323650
53SMAD4_21799915_ChIP-Seq_A2780_Human1.29034794
54AR_19668381_ChIP-Seq_PC3_Human1.26601024
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26132134
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.26020987
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25701359
58ZNF274_21170338_ChIP-Seq_K562_Hela1.23715747
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.22940051
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.21684778
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19833935
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17768519
63* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17408495
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17103828
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17094744
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16058351
67* VDR_21846776_ChIP-Seq_THP-1_Human1.15824194
68* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15218993
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14607046
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14339395
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12387591
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11220522
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11118703
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10444269
75RACK7_27058665_Chip-Seq_MCF-7_Human1.10067125
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09205205
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07120720
78CTCF_27219007_Chip-Seq_Bcells_Human1.06925454
79* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06614031
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06409276
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.06220477
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05825026
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05396101
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03788869
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02397560
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02069503
87STAT3_23295773_ChIP-Seq_U87_Human1.01761729
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01732148
89AR_25329375_ChIP-Seq_VCAP_Human0.99546712
90LXR_22292898_ChIP-Seq_THP-1_Human0.99382349
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.99092327
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98857906
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98502023
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97604935
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.95832078
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.95693082
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95644369
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.95252196
99KDM2B_26808549_Chip-Seq_DND41_Human0.94460051
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93982256
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93803980
102SMAD3_21741376_ChIP-Seq_EPCs_Human0.93779639
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93762848
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.93278029
105KDM2B_26808549_Chip-Seq_JURKAT_Human0.93022617
106CBX2_27304074_Chip-Seq_ESCs_Mouse0.91592092
107SMC4_20622854_ChIP-Seq_HELA_Human0.90348604
108SA1_27219007_Chip-Seq_Bcells_Human0.89852732
109* ELF1_20517297_ChIP-Seq_JURKAT_Human0.88819636
110* TP53_23651856_ChIP-Seq_MEFs_Mouse0.88687328
111DPY_21335234_ChIP-Seq_ESCs_Mouse0.88679177
112SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88250215
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88064292
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87798655
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.86676839
116TCF4_23295773_ChIP-Seq_U87_Human0.86388058
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85449090
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85371333
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85215885
120KLF4_19829295_ChIP-Seq_ESCs_Human0.85069495
121BCOR_27268052_Chip-Seq_Bcells_Human0.84339333
122BCL6_27268052_Chip-Seq_Bcells_Human0.83745329
123* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83493133
124SMAD4_21741376_ChIP-Seq_ESCs_Human0.83089145
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.82931238
126* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.82792894
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82518092
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.82082345
129RXR_22108803_ChIP-Seq_LS180_Human0.81460728
130AHR_22903824_ChIP-Seq_MCF-7_Human0.80272089
131* P300_19829295_ChIP-Seq_ESCs_Human0.78564683
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78037536
133TAF15_26573619_Chip-Seq_HEK293_Human0.77946817
134OCT4_19829295_ChIP-Seq_ESCs_Human0.77759538
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77746482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.44439745
2MP0003880_abnormal_central_pattern4.32473402
3MP0003635_abnormal_synaptic_transmissio4.29786691
4MP0002822_catalepsy3.66685631
5MP0004270_analgesia3.50456037
6MP0009745_abnormal_behavioral_response3.41957205
7MP0002063_abnormal_learning/memory/cond3.40565924
8MP0002064_seizures3.09522838
9MP0009046_muscle_twitch2.92968053
10MP0005423_abnormal_somatic_nervous2.89714971
11MP0001968_abnormal_touch/_nociception2.82614231
12MP0002572_abnormal_emotion/affect_behav2.71977825
13MP0002272_abnormal_nervous_system2.49673334
14MP0001486_abnormal_startle_reflex2.48131463
15MP0002734_abnormal_mechanical_nocicepti2.44856874
16MP0008569_lethality_at_weaning2.18995648
17MP0009780_abnormal_chondrocyte_physiolo2.11739333
18MP0002909_abnormal_adrenal_gland2.09467879
19MP0001501_abnormal_sleep_pattern2.03978481
20MP0002736_abnormal_nociception_after2.03288992
21MP0004811_abnormal_neuron_physiology1.95771196
22MP0005646_abnormal_pituitary_gland1.93185317
23MP0002735_abnormal_chemical_nociception1.90398140
24MP0002733_abnormal_thermal_nociception1.89407115
25MP0001970_abnormal_pain_threshold1.84936366
26MP0004858_abnormal_nervous_system1.81288951
27MP0002557_abnormal_social/conspecific_i1.78947518
28MP0002184_abnormal_innervation1.78433696
29MP0002067_abnormal_sensory_capabilities1.78142647
30MP0001440_abnormal_grooming_behavior1.75063121
31MP0003879_abnormal_hair_cell1.72984534
32MP0000778_abnormal_nervous_system1.66542346
33MP0003787_abnormal_imprinting1.63678160
34MP0000955_abnormal_spinal_cord1.61970366
35MP0003329_amyloid_beta_deposits1.60424200
36MP0001348_abnormal_lacrimal_gland1.58893022
37MP0004924_abnormal_behavior1.58479380
38MP0005386_behavior/neurological_phenoty1.58479380
39MP0004885_abnormal_endolymph1.48766152
40MP0001984_abnormal_olfaction1.46141819
41MP0003122_maternal_imprinting1.40273578
42MP0002882_abnormal_neuron_morphology1.39854739
43MP0003633_abnormal_nervous_system1.38482042
44MP0003283_abnormal_digestive_organ1.38056824
45MP0002066_abnormal_motor_capabilities/c1.37136461
46MP0008961_abnormal_basal_metabolism1.34293736
47MP0005645_abnormal_hypothalamus_physiol1.34138239
48MP0001502_abnormal_circadian_rhythm1.32041483
49MP0002249_abnormal_larynx_morphology1.29626829
50MP0000569_abnormal_digit_pigmentation1.18156043
51MP0001346_abnormal_lacrimal_gland1.18121581
52MP0001986_abnormal_taste_sensitivity1.16810453
53MP0002152_abnormal_brain_morphology1.13540526
54MP0001529_abnormal_vocalization1.12073468
55MP0003631_nervous_system_phenotype1.11415056
56MP0004742_abnormal_vestibular_system1.11214314
57MP0003075_altered_response_to1.10439757
58MP0005499_abnormal_olfactory_system1.04831396
59MP0005394_taste/olfaction_phenotype1.04831396
60MP0000751_myopathy1.04719957
61* MP0002069_abnormal_eating/drinking_beha1.01511615
62MP0004145_abnormal_muscle_electrophysio0.98680578
63MP0006276_abnormal_autonomic_nervous0.97680242
64MP0008874_decreased_physiological_sensi0.95972443
65MP0004130_abnormal_muscle_cell0.93651347
66MP0008872_abnormal_physiological_respon0.92663701
67MP0004142_abnormal_muscle_tone0.91378109
68MP0004085_abnormal_heartbeat0.90738462
69MP0001177_atelectasis0.89901742
70MP0000013_abnormal_adipose_tissue0.88390083
71MP0001188_hyperpigmentation0.88072324
72MP0005167_abnormal_blood-brain_barrier0.83710428
73MP0004233_abnormal_muscle_weight0.81225636
74MP0000631_abnormal_neuroendocrine_gland0.80470420
75MP0002229_neurodegeneration0.80163750
76MP0005551_abnormal_eye_electrophysiolog0.79512739
77MP0004510_myositis0.78963781
78MP0001905_abnormal_dopamine_level0.76600566
79MP0003137_abnormal_impulse_conducting0.76005347
80MP0003172_abnormal_lysosome_physiology0.75922084
81MP0003632_abnormal_nervous_system0.73794607
82MP0003938_abnormal_ear_development0.72867738
83MP0009278_abnormal_bone_marrow0.72777920
84MP0005535_abnormal_body_temperature0.72359232
85MP0002090_abnormal_vision0.71470179
86MP0002089_abnormal_postnatal_growth/wei0.71246164
87MP0004215_abnormal_myocardial_fiber0.70471491
88MP0005409_darkened_coat_color0.70363835
89MP0000681_abnormal_thyroid_gland0.69577790
90MP0003705_abnormal_hypodermis_morpholog0.68951070
91MP0003634_abnormal_glial_cell0.67982883
92MP0002234_abnormal_pharynx_morphology0.67407868
93MP0010386_abnormal_urinary_bladder0.66221529
94MP0000566_synostosis0.65462414
95MP0008260_abnormal_autophagy0.65022738
96MP0003690_abnormal_glial_cell0.64469156
97MP0002653_abnormal_ependyma_morphology0.64183549
98MP0002752_abnormal_somatic_nervous0.63439402
99MP0003861_abnormal_nervous_system0.62794512
100MP0000026_abnormal_inner_ear0.60519254
101MP0001963_abnormal_hearing_physiology0.60454252
102MP0010769_abnormal_survival0.59480027
103MP0003123_paternal_imprinting0.59452377
104MP0001664_abnormal_digestion0.59004972
105MP0005623_abnormal_meninges_morphology0.57689340
106MP0001299_abnormal_eye_distance/0.57370576
107MP0000604_amyloidosis0.57019423
108MP0002638_abnormal_pupillary_reflex0.56338401
109MP0010768_mortality/aging0.56132667
110MP0010770_preweaning_lethality0.55345125
111MP0002082_postnatal_lethality0.55345125
112MP0001943_abnormal_respiration0.55254599
113MP0005166_decreased_susceptibility_to0.55043575
114MP0000920_abnormal_myelination0.54731323
115MP0001485_abnormal_pinna_reflex0.53651472
116MP0000747_muscle_weakness0.48848066
117* MP0003956_abnormal_body_size0.45628954
118MP0001731_abnormal_postnatal_growth0.45421345
119MP0002873_normal_phenotype0.45355510

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.41958432
2Focal motor seizures (HP:0011153)7.19288947
3Focal seizures (HP:0007359)5.55025955
4Visual hallucinations (HP:0002367)5.47071651
5Neurofibrillary tangles (HP:0002185)4.55656000
6Epileptic encephalopathy (HP:0200134)4.43891884
7Action tremor (HP:0002345)4.26754369
8Progressive cerebellar ataxia (HP:0002073)4.26646742
9Febrile seizures (HP:0002373)4.09082167
10Cerebral inclusion bodies (HP:0100314)3.73061800
11Absence seizures (HP:0002121)3.71455374
12Poor eye contact (HP:0000817)3.69983584
13Atonic seizures (HP:0010819)3.62499244
14Depression (HP:0000716)3.62141167
15Ankle clonus (HP:0011448)3.57304633
16Gaze-evoked nystagmus (HP:0000640)3.39661642
17Dialeptic seizures (HP:0011146)3.37765234
18Generalized tonic-clonic seizures (HP:0002069)3.36983633
19Abnormal social behavior (HP:0012433)3.32176251
20Impaired social interactions (HP:0000735)3.32176251
21Abnormality of the lower motor neuron (HP:0002366)3.28954010
22Broad-based gait (HP:0002136)3.28819853
23Impaired vibration sensation in the lower limbs (HP:0002166)3.28155865
24Genetic anticipation (HP:0003743)3.21389020
25Supranuclear gaze palsy (HP:0000605)3.14948364
26Annular pancreas (HP:0001734)3.07250652
27Torticollis (HP:0000473)3.04739001
28Dysdiadochokinesis (HP:0002075)3.04670885
29Urinary bladder sphincter dysfunction (HP:0002839)3.02680633
30Anxiety (HP:0000739)3.00405708
31Truncal ataxia (HP:0002078)2.99318103
32Impaired smooth pursuit (HP:0007772)2.99306803
33Postural instability (HP:0002172)2.93279336
34Papilledema (HP:0001085)2.87930230
35Focal dystonia (HP:0004373)2.86924323
36Dysmetria (HP:0001310)2.86720957
37Pointed chin (HP:0000307)2.86450380
38Hemiplegia (HP:0002301)2.86128490
39Akinesia (HP:0002304)2.80794089
40Dysmetric saccades (HP:0000641)2.79652437
41Ventricular fibrillation (HP:0001663)2.71483658
42Abnormal eating behavior (HP:0100738)2.70978371
43Hemiparesis (HP:0001269)2.68762141
44Stereotypic behavior (HP:0000733)2.67631150
45Mutism (HP:0002300)2.67424188
46Insomnia (HP:0100785)2.64672473
47Abnormality of ocular smooth pursuit (HP:0000617)2.64246478
48Peripheral hypomyelination (HP:0007182)2.64137663
49Delusions (HP:0000746)2.56621489
50Cerebral hypomyelination (HP:0006808)2.54648978
51Bundle branch block (HP:0011710)2.53137355
52Urinary urgency (HP:0000012)2.52144242
53Craniofacial dystonia (HP:0012179)2.50360380
54Megalencephaly (HP:0001355)2.49685053
55Spastic gait (HP:0002064)2.47701719
56Scanning speech (HP:0002168)2.46470401
57Amblyopia (HP:0000646)2.44067286
58Intention tremor (HP:0002080)2.43415523
59Bradykinesia (HP:0002067)2.38683087
60Diminished motivation (HP:0000745)2.36207037
61Turricephaly (HP:0000262)2.32042403
62Spinal canal stenosis (HP:0003416)2.30186280
63Excessive salivation (HP:0003781)2.29886151
64Drooling (HP:0002307)2.29886151
65Agitation (HP:0000713)2.28346076
66Abnormality of binocular vision (HP:0011514)2.27313484
67Diplopia (HP:0000651)2.27313484
68Epileptiform EEG discharges (HP:0011182)2.26311826
69EEG with generalized epileptiform discharges (HP:0011198)2.24006976
70Bronchomalacia (HP:0002780)2.23440055
71Polyphagia (HP:0002591)2.20598318
72Abnormal EKG (HP:0003115)2.20202829
73Obstructive sleep apnea (HP:0002870)2.18717973
74Hypsarrhythmia (HP:0002521)2.18105682
75Neoplasm of the heart (HP:0100544)2.17117166
76Impaired vibratory sensation (HP:0002495)2.14748524
77Hyperacusis (HP:0010780)2.10381845
78Upper limb amyotrophy (HP:0009129)2.09426311
79Amyotrophic lateral sclerosis (HP:0007354)2.07907132
80Progressive inability to walk (HP:0002505)2.07231883
81Status epilepticus (HP:0002133)2.04940628
82Ankyloglossia (HP:0010296)2.04368500
83Shallow orbits (HP:0000586)2.02274666
84Clonus (HP:0002169)2.01439099
85Hypercortisolism (HP:0001578)2.01199757
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97533041
87Lower limb muscle weakness (HP:0007340)1.97513488
88Cerebral aneurysm (HP:0004944)1.96210703
89Incomplete penetrance (HP:0003829)1.96126950
90Hyperventilation (HP:0002883)1.94604548
91Hand muscle atrophy (HP:0009130)1.93611715
92Aplasia involving bones of the upper limbs (HP:0009823)1.92817490
93Aplasia of the phalanges of the hand (HP:0009802)1.92817490
94Aplasia involving bones of the extremities (HP:0009825)1.92817490
95Lower limb amyotrophy (HP:0007210)1.92569498
96Elfin facies (HP:0004428)1.89490375
97Prolonged QT interval (HP:0001657)1.88749093
98Tetraplegia (HP:0002445)1.88589768
99Fetal akinesia sequence (HP:0001989)1.86378903
100Abnormality of the corticospinal tract (HP:0002492)1.85251236
101Dementia (HP:0000726)1.81408938
102Choreoathetosis (HP:0001266)1.81144645
103Ocular albinism (HP:0001107)1.81126615
104Absent speech (HP:0001344)1.80470353
105Spastic tetraparesis (HP:0001285)1.79805210
106Limb dystonia (HP:0002451)1.79473777
107Abnormality of saccadic eye movements (HP:0000570)1.79392768
108Gait ataxia (HP:0002066)1.78768934
109Lower limb asymmetry (HP:0100559)1.78760125
110Macroorchidism (HP:0000053)1.77855867
111Neuronal loss in central nervous system (HP:0002529)1.75155548
112Iris hypopigmentation (HP:0007730)1.74491716
113Resting tremor (HP:0002322)1.73679669
114Limb ataxia (HP:0002070)1.72230250
115Obsessive-compulsive behavior (HP:0000722)1.71587085
116Memory impairment (HP:0002354)1.71456834
117Slow saccadic eye movements (HP:0000514)1.70864296
118Rigidity (HP:0002063)1.69778139
119Slow progression (HP:0003677)1.69263280
120Psychosis (HP:0000709)1.68691331
121Hypoventilation (HP:0002791)1.66649929
122Abnormality of the periventricular white matter (HP:0002518)1.65425644
123Rapidly progressive (HP:0003678)1.64120994
124Generalized myoclonic seizures (HP:0002123)1.61959175
125Apathy (HP:0000741)1.61491865
126Sleep apnea (HP:0010535)1.57848993
127Distal upper limb amyotrophy (HP:0007149)1.56311361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.91886181
2NTRK34.41287745
3MAP3K93.75289530
4PRKD32.84849026
5DAPK22.79198363
6MARK12.78358666
7MINK12.64951412
8MAP3K42.56753261
9PAK62.36521525
10CAMKK12.36088752
11KSR22.29590703
12NTRK22.28008979
13KSR11.90200785
14MAP2K71.84971682
15SIK21.70906109
16NTRK11.65809319
17STK381.61443656
18CDK51.60872377
19DAPK11.60627121
20PRPF4B1.48108689
21FES1.48005516
22MAP2K41.43146265
23TNIK1.40372919
24TAOK11.38417919
25MAP3K111.38384893
26RIPK11.33218303
27TYRO31.32355794
28UHMK11.25933395
29MAP3K131.24953556
30RIPK41.22378907
31MAPK121.21106533
32CAMK11.20744374
33PRKCH1.19387220
34MAP3K21.19203210
35CAMKK21.19070287
36SIK31.17004929
37CDK191.13443272
38MAPK131.13293220
39PRKCG1.12528481
40MAP3K121.12313394
41ARAF1.03981119
42SGK31.02695482
43SIK11.02118005
44SGK21.01592778
45SGK2231.00794910
46SGK4941.00794910
47ALK1.00552983
48LMTK21.00093183
49MARK20.96633244
50PKN10.93066718
51PINK10.92560918
52GRK50.90939179
53RET0.88575888
54PHKG10.88401840
55PHKG20.88401840
56CDK180.86174165
57STK110.83209454
58CDK150.82197477
59TNK20.81093139
60RAF10.80705814
61CDK140.77109451
62CAMK40.76456539
63MAP3K70.75282736
64PTK2B0.74651487
65TESK10.74082562
66SGK10.71997538
67ICK0.71891990
68CDK11A0.71793555
69CDC42BPA0.71233801
70PLK20.70924803
71MAP3K10.70289674
72PDK10.69258712
73CAMK2A0.68645817
74FGFR20.68040783
75CAMK2G0.67246597
76EEF2K0.66710699
77PDPK10.62680464
78PAK30.61804075
79PRKD20.61282219
80BRAF0.60827371
81LATS20.59948759
82TAOK20.59253018
83DYRK1A0.58576044
84CAMK1D0.58131050
85CAMK2B0.57404710
86RPS6KA30.55585249
87ERN10.55138696
88NEK10.54727261
89IRAK20.53964204
90WNK30.53845764
91BRSK10.52817298
92PDGFRA0.52729501
93TRIB30.52526031
94WNK10.51000454
95PRKCZ0.50593327
96MAPK100.49917502
97CAMK1G0.49916327
98SMG10.48333602
99RPS6KA20.48331890
100DMPK0.48096654
101NEK60.46605529
102FYN0.46036294
103HIPK20.42351438
104DYRK1B0.42330495
105FER0.41996277
106CDK120.41903865
107MAPK40.39505325
108MAP2K10.38168951
109MAP2K60.37422185
110SCYL20.36990036
111DAPK30.36849308
112PRKD10.36664527
113CSNK1G20.36386184
114LIMK10.36328955
115ROCK20.36232700
116CASK0.35748789
117MAPK80.35325985
118DDR20.32568375
119PRKCB0.30600664
120GSK3B0.28342665
121ERBB20.27684780

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.23119284
2Synaptic vesicle cycle_Homo sapiens_hsa047213.05281092
3Olfactory transduction_Homo sapiens_hsa047402.85452124
4Circadian entrainment_Homo sapiens_hsa047132.77829199
5Long-term potentiation_Homo sapiens_hsa047202.56570054
6GABAergic synapse_Homo sapiens_hsa047272.56200775
7Glutamatergic synapse_Homo sapiens_hsa047242.54601018
8Morphine addiction_Homo sapiens_hsa050322.45086483
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42162197
10Amphetamine addiction_Homo sapiens_hsa050312.35813684
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22494564
12Insulin secretion_Homo sapiens_hsa049112.18084561
13Dopaminergic synapse_Homo sapiens_hsa047282.08534500
14Salivary secretion_Homo sapiens_hsa049702.05784184
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.04489466
16Cholinergic synapse_Homo sapiens_hsa047251.99326019
17Gastric acid secretion_Homo sapiens_hsa049711.87601380
18Cocaine addiction_Homo sapiens_hsa050301.75206175
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72633679
20Oxytocin signaling pathway_Homo sapiens_hsa049211.68527100
21Taste transduction_Homo sapiens_hsa047421.64091200
22Long-term depression_Homo sapiens_hsa047301.60653899
23Calcium signaling pathway_Homo sapiens_hsa040201.54724651
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52528073
25Type II diabetes mellitus_Homo sapiens_hsa049301.49635130
26Renin secretion_Homo sapiens_hsa049241.48567488
27GnRH signaling pathway_Homo sapiens_hsa049121.47061110
28Serotonergic synapse_Homo sapiens_hsa047261.40722640
29cAMP signaling pathway_Homo sapiens_hsa040241.35255331
30Gap junction_Homo sapiens_hsa045401.34499226
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33824244
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25826964
33Glioma_Homo sapiens_hsa052141.25559382
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22565357
35Estrogen signaling pathway_Homo sapiens_hsa049151.18400989
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16372573
37Nitrogen metabolism_Homo sapiens_hsa009101.16334155
38ErbB signaling pathway_Homo sapiens_hsa040121.11051682
39Vitamin B6 metabolism_Homo sapiens_hsa007501.10008947
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09179573
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08344038
42Axon guidance_Homo sapiens_hsa043601.05740670
43Melanogenesis_Homo sapiens_hsa049161.05298907
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02492719
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.97696169
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94342515
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93715599
48Pancreatic secretion_Homo sapiens_hsa049720.92618108
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.87731899
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.87585395
51Dorso-ventral axis formation_Homo sapiens_hsa043200.84507042
52Oocyte meiosis_Homo sapiens_hsa041140.84288354
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83446157
54Choline metabolism in cancer_Homo sapiens_hsa052310.81659111
55Dilated cardiomyopathy_Homo sapiens_hsa054140.80754377
56Thyroid hormone synthesis_Homo sapiens_hsa049180.79227904
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78198283
58mTOR signaling pathway_Homo sapiens_hsa041500.75876026
59Collecting duct acid secretion_Homo sapiens_hsa049660.74817499
60Circadian rhythm_Homo sapiens_hsa047100.74328501
61VEGF signaling pathway_Homo sapiens_hsa043700.74244326
62MAPK signaling pathway_Homo sapiens_hsa040100.74034731
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72520795
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71712505
65Non-small cell lung cancer_Homo sapiens_hsa052230.70255732
66Endometrial cancer_Homo sapiens_hsa052130.69248654
67Cardiac muscle contraction_Homo sapiens_hsa042600.65678066
68Notch signaling pathway_Homo sapiens_hsa043300.64657531
69Glucagon signaling pathway_Homo sapiens_hsa049220.62918655
70Phototransduction_Homo sapiens_hsa047440.62698072
71Rap1 signaling pathway_Homo sapiens_hsa040150.62286211
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61875751
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60720261
74Endocytosis_Homo sapiens_hsa041440.59745060
75Inositol phosphate metabolism_Homo sapiens_hsa005620.56564398
76B cell receptor signaling pathway_Homo sapiens_hsa046620.54940476
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54324808
78Ras signaling pathway_Homo sapiens_hsa040140.54126531
79Wnt signaling pathway_Homo sapiens_hsa043100.53543768
80Vibrio cholerae infection_Homo sapiens_hsa051100.53461217
81Type I diabetes mellitus_Homo sapiens_hsa049400.52064225
82Insulin signaling pathway_Homo sapiens_hsa049100.51716492
83Alcoholism_Homo sapiens_hsa050340.51577430
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50999805
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50010863
86Bile secretion_Homo sapiens_hsa049760.48455820
87AMPK signaling pathway_Homo sapiens_hsa041520.48157819
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.47005457
89Colorectal cancer_Homo sapiens_hsa052100.46669237
90Chemokine signaling pathway_Homo sapiens_hsa040620.45031511
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43760874
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41518696
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41507910
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41049829
95Renal cell carcinoma_Homo sapiens_hsa052110.40263085
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39893553
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39846561
98Acute myeloid leukemia_Homo sapiens_hsa052210.38855164
99Prolactin signaling pathway_Homo sapiens_hsa049170.38102170
100Platelet activation_Homo sapiens_hsa046110.36451561
101Ovarian steroidogenesis_Homo sapiens_hsa049130.35702643
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.35387064
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34704462
104Osteoclast differentiation_Homo sapiens_hsa043800.34693356
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32768702
106Prion diseases_Homo sapiens_hsa050200.31810721
107HIF-1 signaling pathway_Homo sapiens_hsa040660.30846340
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.30751563
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29609699
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28703103
111Chronic myeloid leukemia_Homo sapiens_hsa052200.23635463

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