CRTC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.57749268
2negative regulation of cell killing (GO:0031342)4.57749268
3negative regulation of erythrocyte differentiation (GO:0045647)4.38622964
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.11063759
5antigen processing and presentation of endogenous antigen (GO:0019883)3.88003667
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85655528
7positive regulation of gamma-delta T cell activation (GO:0046645)3.82256485
8mannose metabolic process (GO:0006013)3.81709043
9response to laminar fluid shear stress (GO:0034616)3.71601260
10interferon-gamma production (GO:0032609)3.35727874
11positive thymic T cell selection (GO:0045059)3.31518438
12histone H3-K4 trimethylation (GO:0080182)3.17994875
13positive T cell selection (GO:0043368)3.09384505
14positive regulation of cellular amide metabolic process (GO:0034250)3.08994535
15histone H3-K36 demethylation (GO:0070544)3.08257537
16leukocyte aggregation (GO:0070486)3.05714145
17positive regulation of macrophage differentiation (GO:0045651)2.99695290
18B cell receptor signaling pathway (GO:0050853)2.98425332
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94478812
20superoxide anion generation (GO:0042554)2.90027437
21detection of molecule of bacterial origin (GO:0032490)2.89970277
22regulation of T cell tolerance induction (GO:0002664)2.89616377
23negative regulation of lymphocyte mediated immunity (GO:0002707)2.85961449
24tolerance induction (GO:0002507)2.85401745
25regulation of male gonad development (GO:2000018)2.83001689
26detection of bacterium (GO:0016045)2.81909956
27positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.79726997
28detection of other organism (GO:0098543)2.79466717
29regulation of gamma-delta T cell activation (GO:0046643)2.78931547
30mesenchymal cell differentiation involved in renal system development (GO:2001012)2.78267952
31mesenchymal cell differentiation involved in kidney development (GO:0072161)2.78267952
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76401086
33lymph node development (GO:0048535)2.69520529
34T cell migration (GO:0072678)2.68942760
35negative regulation of granulocyte differentiation (GO:0030853)2.68782627
36embryonic process involved in female pregnancy (GO:0060136)2.67128846
37regulation of extracellular matrix disassembly (GO:0010715)2.66821044
38positive regulation of natural killer cell differentiation (GO:0032825)2.66153341
39negative regulation of leukocyte mediated immunity (GO:0002704)2.65550827
40regulation of alpha-beta T cell proliferation (GO:0046640)2.64551482
41macrophage activation involved in immune response (GO:0002281)2.63733101
42response to muramyl dipeptide (GO:0032495)2.61933345
43polyketide metabolic process (GO:0030638)2.61651161
44doxorubicin metabolic process (GO:0044598)2.61651161
45daunorubicin metabolic process (GO:0044597)2.61651161
46regulation of histone H3-K27 methylation (GO:0061085)2.61430411
47cellular response to epinephrine stimulus (GO:0071872)2.60759769
48cellular response to interleukin-15 (GO:0071350)2.59948758
49NIK/NF-kappaB signaling (GO:0038061)2.59759367
50regulation of ARF protein signal transduction (GO:0032012)2.58867089
51dendritic cell chemotaxis (GO:0002407)2.58344480
52positive regulation of histone deacetylation (GO:0031065)2.58283001
53regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58271081
54thymic T cell selection (GO:0045061)2.58150188
55response to fluid shear stress (GO:0034405)2.56292061
56regulation of interleukin-2 biosynthetic process (GO:0045076)2.53906872
57positive regulation by symbiont of host defense response (GO:0052509)2.52241489
58modulation by symbiont of host defense response (GO:0052031)2.52241489
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52241489
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52241489
61positive regulation by organism of defense response of other organism involved in symbiotic interact2.52241489
62modulation by symbiont of host immune response (GO:0052553)2.52241489
63response to type I interferon (GO:0034340)2.51158491
64positive regulation of Rap GTPase activity (GO:0032854)2.50580769
65regulation of tolerance induction (GO:0002643)2.50535793
66positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49627770
67regulation of gamma-delta T cell differentiation (GO:0045586)2.49543889
68T cell selection (GO:0045058)2.49225382
69T cell receptor signaling pathway (GO:0050852)2.48139659
70positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48129180
71antigen receptor-mediated signaling pathway (GO:0050851)2.47926203
72cellular response to type I interferon (GO:0071357)2.45690792
73type I interferon signaling pathway (GO:0060337)2.45690792
74negative regulation of glycoprotein biosynthetic process (GO:0010561)2.45057810
75activated T cell proliferation (GO:0050798)2.40716302
76dendritic cell migration (GO:0036336)2.38918261
77lymphocyte homeostasis (GO:0002260)2.37734293
78regulation of macrophage differentiation (GO:0045649)2.37538412
79negative T cell selection (GO:0043383)2.36773748
80negative regulation of interleukin-12 production (GO:0032695)2.36648780
81positive regulation of T cell mediated cytotoxicity (GO:0001916)2.35854509
82regulation of interleukin-12 biosynthetic process (GO:0045075)2.35570344
83regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.34737093
84definitive hemopoiesis (GO:0060216)2.34619057
85negative regulation of innate immune response (GO:0045824)2.33713370
86positive regulation of interleukin-2 production (GO:0032743)2.32917297
87CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.32488272
88T-helper cell differentiation (GO:0042093)2.32488272
89response to interleukin-15 (GO:0070672)2.32365915
90cellular extravasation (GO:0045123)2.32286481
91regulation of ARF GTPase activity (GO:0032312)2.32035852
92response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.30492428
93response to host immune response (GO:0052572)2.30492428
94regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.29744239
95negative regulation of bone resorption (GO:0045779)2.29694645
96positive regulation of tolerance induction (GO:0002645)2.29113592
97embryonic camera-type eye morphogenesis (GO:0048596)2.28945084
98regulation of interferon-beta biosynthetic process (GO:0045357)2.27596788
99regulation of regulatory T cell differentiation (GO:0045589)2.27414463
100negative thymic T cell selection (GO:0045060)2.27009033
101positive regulation of protein deacetylation (GO:0090312)2.27001431
102signal complex assembly (GO:0007172)2.26970075
103positive regulation of alpha-beta T cell proliferation (GO:0046641)2.26753875
104neutrophil activation (GO:0042119)2.26078724
105myeloid dendritic cell activation (GO:0001773)2.26037509
106androgen biosynthetic process (GO:0006702)2.25458279
107CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.25326715
108tyrosine phosphorylation of STAT protein (GO:0007260)2.25223435
109regulation of T-helper 2 cell differentiation (GO:0045628)2.24875832
110regulation of B cell receptor signaling pathway (GO:0050855)2.24316357
111positive regulation of male gonad development (GO:2000020)2.22318504
112negative regulation of T-helper cell differentiation (GO:0045623)2.21204226
113positive regulation of heat generation (GO:0031652)2.20677656
114cell differentiation involved in metanephros development (GO:0072202)2.19642238
115modulation by virus of host process (GO:0019054)2.19510120
116germinal center formation (GO:0002467)2.18656924
117coronary vasculature morphogenesis (GO:0060977)2.17231277
118detection of external biotic stimulus (GO:0098581)2.17225434
119response to peptidoglycan (GO:0032494)2.15998320
120G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.14792496
121response to host (GO:0075136)2.14768857
122response to host defenses (GO:0052200)2.14768857
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.14768857
124male sex determination (GO:0030238)2.14489783
125positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.14455471
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.14433850
127regulation of necroptotic process (GO:0060544)2.13897508
128regulation of dendritic cell antigen processing and presentation (GO:0002604)2.12587345
129negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.12301431
130regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.11396462
131positive regulation of antigen processing and presentation (GO:0002579)2.11138783
132regulation of hypersensitivity (GO:0002883)2.10882814
133positive regulation of tumor necrosis factor production (GO:0032760)2.09760527
134regulation of granulocyte differentiation (GO:0030852)2.09388468
135sex determination (GO:0007530)2.08977985
136modulation by symbiont of host cellular process (GO:0044068)2.07605265
137granulocyte activation (GO:0036230)2.07289702
138CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.07165181
139positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.07094706
140myeloid dendritic cell differentiation (GO:0043011)2.05553384
141negative regulation of T cell mediated immunity (GO:0002710)2.05524180
142positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.03774019
143regulation of cellular extravasation (GO:0002691)2.02407091
144B cell homeostasis (GO:0001782)2.01837406
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.01634192
146positive regulation of granulocyte differentiation (GO:0030854)2.00129210
147positive regulation of mast cell degranulation (GO:0043306)1.99701678
148positive regulation of mast cell activation involved in immune response (GO:0033008)1.99701678
149T cell homeostasis (GO:0043029)1.98969650
150regulation of interleukin-8 secretion (GO:2000482)1.98711384
151positive regulation of interleukin-1 beta secretion (GO:0050718)1.98160073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12760587
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.89373548
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.14585985
4MYC_22102868_ChIP-Seq_BL_Human2.96633419
5VDR_21846776_ChIP-Seq_THP-1_Human2.79063446
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.78095076
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.77820146
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73324261
9KDM2B_26808549_Chip-Seq_DND41_Human2.55995992
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.50042027
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.38146716
12* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.37354473
13RUNX_20019798_ChIP-Seq_JUKART_Human2.10749087
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08844829
15SCL_19346495_ChIP-Seq_HPC-7_Human2.08653107
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.08328286
17UTX_26944678_Chip-Seq_JUKART_Human2.02558222
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01462774
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01135607
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99166635
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98811710
22VDR_24763502_ChIP-Seq_THP-1_Human1.97347967
23KDM2B_26808549_Chip-Seq_JURKAT_Human1.96288709
24LXR_22292898_ChIP-Seq_THP-1_Human1.90620705
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89521763
26MAF_26560356_Chip-Seq_TH2_Human1.88478007
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81827903
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78310348
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.77694685
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.76879802
31* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75048561
32GBX2_23144817_ChIP-Seq_PC3_Human1.71585583
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70428736
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65633309
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64590663
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63502460
37DROSHA_22980978_ChIP-Seq_HELA_Human1.59370646
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.59050132
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.58811528
40* KDM2B_26808549_Chip-Seq_K562_Human1.58776816
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.58192868
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57030703
43VDR_24787735_ChIP-Seq_THP-1_Human1.54160489
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.53533586
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48509046
46* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45740309
47GATA1_22025678_ChIP-Seq_K562_Human1.45531327
48* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43097686
49RACK7_27058665_Chip-Seq_MCF-7_Human1.40822907
50* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39502215
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39224860
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36211474
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36012159
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35804907
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34471823
56SMC4_20622854_ChIP-Seq_HELA_Human1.31650309
57AHR_22903824_ChIP-Seq_MCF-7_Human1.30464416
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25293228
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25225228
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24557341
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.24448499
62GATA1_19941826_ChIP-Seq_K562_Human1.24341652
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23967485
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23394944
65TP53_16413492_ChIP-PET_HCT116_Human1.21103881
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20366180
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.19410432
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19067697
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18477340
70GATA3_27048872_Chip-Seq_THYMUS_Human1.18377612
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.18152756
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17770514
73TP53_18474530_ChIP-ChIP_U2OS_Human1.17098401
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16293904
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.15071463
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14972301
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14484415
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14401510
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12846450
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12259931
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11391467
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11267337
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09509646
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.09403873
85* RNF2_27304074_Chip-Seq_ESCs_Mouse1.09398762
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07994410
87IGF1R_20145208_ChIP-Seq_DFB_Human1.07923067
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07532688
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06142033
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05830704
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.05015030
92CJUN_26792858_Chip-Seq_BT549_Human1.04991007
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04965741
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.04778125
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04713560
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.04663147
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04460668
98* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04398039
99SPI1_23127762_ChIP-Seq_K562_Human1.04353066
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03320264
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.03073606
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.03073606
103CIITA_25753668_ChIP-Seq_RAJI_Human1.02669308
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01661178
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01111446
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00360688
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.99880262
108NFE2_27457419_Chip-Seq_LIVER_Mouse0.99785028
109P68_20966046_ChIP-Seq_HELA_Human0.99592843
110EZH2_27304074_Chip-Seq_ESCs_Mouse0.99153992
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99106632
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98872316
113EZH2_27294783_Chip-Seq_ESCs_Mouse0.97944534
114TCF7_22412390_ChIP-Seq_EML_Mouse0.97384980
115SPI1_23547873_ChIP-Seq_NB4_Human0.97282787
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.95130496
117* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94892515
118* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94892515
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94735064
120NCOR1_26117541_ChIP-Seq_K562_Human0.94116437
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93887934
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93883932
123* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93577632
124* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93494886
125PU_27001747_Chip-Seq_BMDM_Mouse0.93399678
126MYB_26560356_Chip-Seq_TH2_Human0.93207361
127SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93155495
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.92849638
129CREB1_26743006_Chip-Seq_LNCaP_Human0.92353937
130ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91998551
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91932077
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.91838878
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91811386
134* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91440265
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91298883
136SMAD4_21799915_ChIP-Seq_A2780_Human0.91138642
137* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91105794
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90074238
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89433398
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89389371
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89141536
142SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89037296
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88980787
144FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88873249
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.88109533
146NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88053513
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87868362
148MYB_26560356_Chip-Seq_TH1_Human0.87383683
149EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86517926
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86488755
151RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86487225
152EZH2_22144423_ChIP-Seq_EOC_Human0.86448605
153JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86280341
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.85220496
155FLI1_27457419_Chip-Seq_LIVER_Mouse0.85163107
156MAF_26560356_Chip-Seq_TH1_Human0.83680160
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83023202
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83023202
159TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82038919
160MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82008970
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81951650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.57122074
2MP0004510_myositis2.78077121
3MP0003763_abnormal_thymus_physiology2.69054097
4MP0001835_abnormal_antigen_presentation2.54558792
5MP0005670_abnormal_white_adipose2.41534935
6MP0005387_immune_system_phenotype2.32276313
7MP0001790_abnormal_immune_system2.32276313
8MP0005671_abnormal_response_to2.30731938
9MP0003724_increased_susceptibility_to2.29431745
10MP0003300_gastrointestinal_ulcer2.29301538
11MP0003045_fibrosis2.16509239
12MP0008995_early_reproductive_senescence2.01638928
13MP0002148_abnormal_hypersensitivity_rea1.98974662
14MP0009840_abnormal_foam_cell1.93507968
15MP0002419_abnormal_innate_immunity1.90244705
16MP0001879_abnormal_lymphatic_vessel1.89744404
17MP0005000_abnormal_immune_tolerance1.84703231
18MP0001348_abnormal_lacrimal_gland1.84324888
19MP0000685_abnormal_immune_system1.82092190
20MP0003436_decreased_susceptibility_to1.81892604
21MP0005174_abnormal_tail_pigmentation1.80883812
22MP0005058_abnormal_lysosome_morphology1.80365162
23MP0001800_abnormal_humoral_immune1.79553146
24MP0003172_abnormal_lysosome_physiology1.79366868
25MP0005076_abnormal_cell_differentiation1.77869661
26MP0002452_abnormal_antigen_presenting1.76803699
27MP0003705_abnormal_hypodermis_morpholog1.76346560
28MP0003828_pulmonary_edema1.74781728
29MP0004130_abnormal_muscle_cell1.74760084
30MP0002166_altered_tumor_susceptibility1.74343829
31MP0003279_aneurysm1.73867684
32MP0002006_tumorigenesis1.72216239
33MP0004808_abnormal_hematopoietic_stem1.71705382
34MP0002723_abnormal_immune_serum1.71286237
35MP0000015_abnormal_ear_pigmentation1.70635439
36MP0005451_abnormal_body_composition1.69848689
37MP0009785_altered_susceptibility_to1.69633665
38MP0009278_abnormal_bone_marrow1.67796705
39MP0005025_abnormal_response_to1.67494081
40MP0005464_abnormal_platelet_physiology1.65782130
41MP0001819_abnormal_immune_cell1.61420457
42MP0003303_peritoneal_inflammation1.61391216
43MP0002420_abnormal_adaptive_immunity1.60382481
44MP0002998_abnormal_bone_remodeling1.59500339
45MP0001958_emphysema1.54702454
46MP0003787_abnormal_imprinting1.53115421
47MP0009764_decreased_sensitivity_to1.52245855
48MP0004381_abnormal_hair_follicle1.49798813
49MP0002405_respiratory_system_inflammati1.48919204
50MP0005409_darkened_coat_color1.44905736
51MP0006292_abnormal_olfactory_placode1.44071246
52MP0002933_joint_inflammation1.40921061
53MP0005377_hearing/vestibular/ear_phenot1.40873239
54MP0003878_abnormal_ear_physiology1.40873239
55MP0002928_abnormal_bile_duct1.39953420
56MP0005310_abnormal_salivary_gland1.36055480
57MP0002396_abnormal_hematopoietic_system1.34178640
58MP0005503_abnormal_tendon_morphology1.33576706
59MP0002398_abnormal_bone_marrow1.32181071
60MP0002009_preneoplasia1.30220839
61MP0009115_abnormal_fat_cell1.29431733
62MP0004947_skin_inflammation1.28478456
63MP0000733_abnormal_muscle_development1.27219235
64MP0008260_abnormal_autophagy1.26651385
65MP0000767_abnormal_smooth_muscle1.25843611
66MP0000716_abnormal_immune_system1.22825191
67MP0001853_heart_inflammation1.22724518
68MP0001188_hyperpigmentation1.22138544
69MP0003191_abnormal_cellular_cholesterol1.21845890
70MP0005645_abnormal_hypothalamus_physiol1.20517649
71MP0005397_hematopoietic_system_phenotyp1.18519757
72MP0001545_abnormal_hematopoietic_system1.18519757
73MP0001873_stomach_inflammation1.11738642
74MP0000703_abnormal_thymus_morphology1.08168301
75MP0001533_abnormal_skeleton_physiology1.07185630
76MP0006138_congestive_heart_failure1.07068425
77MP0003950_abnormal_plasma_membrane1.07006797
78MP0005375_adipose_tissue_phenotype1.06468324
79MP0005275_abnormal_skin_tensile1.05697498
80MP0000383_abnormal_hair_follicle1.04481584
81MP0002877_abnormal_melanocyte_morpholog1.03849547
82MP0005666_abnormal_adipose_tissue1.02840764
83MP0008961_abnormal_basal_metabolism1.02224760
84MP0003941_abnormal_skin_development1.01162036
85MP0001845_abnormal_inflammatory_respons1.00820100
86MP0003866_abnormal_defecation1.00720377
87MP0010155_abnormal_intestine_physiology1.00226286
88MP0005075_abnormal_melanosome_morpholog0.99716922
89MP0004185_abnormal_adipocyte_glucose0.98574354
90MP0001851_eye_inflammation0.96361463
91MP0010368_abnormal_lymphatic_system0.95615427
92MP0002132_abnormal_respiratory_system0.95280921
93MP0000003_abnormal_adipose_tissue0.95279674
94MP0003943_abnormal_hepatobiliary_system0.93497666
95MP0002722_abnormal_immune_system0.92257043
96MP0002095_abnormal_skin_pigmentation0.90386691
97MP0002429_abnormal_blood_cell0.88910260
98MP0003448_altered_tumor_morphology0.88649358
99MP0002971_abnormal_brown_adipose0.88534787
100MP0004233_abnormal_muscle_weight0.88242323
101MP0005390_skeleton_phenotype0.87635279
102MP0003566_abnormal_cell_adhesion0.86890211
103MP0000465_gastrointestinal_hemorrhage0.85041398
104MP0008469_abnormal_protein_level0.84884563
105MP0003453_abnormal_keratinocyte_physiol0.84061953
106MP0000249_abnormal_blood_vessel0.83992681
107MP0006082_CNS_inflammation0.83266915
108MP0000566_synostosis0.82693252
109MP0002168_other_aberrant_phenotype0.82356234
110MP0000371_diluted_coat_color0.81545681
111MP0000858_altered_metastatic_potential0.81339574
112MP0005023_abnormal_wound_healing0.80819842
113MP0008438_abnormal_cutaneous_collagen0.80676444
114MP0000689_abnormal_spleen_morphology0.80315231
115MP0000678_abnormal_parathyroid_gland0.79828543
116MP0003183_abnormal_peptide_metabolism0.79711228
117MP0003690_abnormal_glial_cell0.79381633
118MP0001346_abnormal_lacrimal_gland0.78366929
119MP0002970_abnormal_white_adipose0.77872654
120MP0000604_amyloidosis0.77539532
121MP0009333_abnormal_splenocyte_physiolog0.77297717
122MP0001502_abnormal_circadian_rhythm0.77273607
123MP0003795_abnormal_bone_structure0.76695851
124MP0002638_abnormal_pupillary_reflex0.76327810
125MP0005083_abnormal_biliary_tract0.75135259
126MP0002108_abnormal_muscle_morphology0.74732703
127MP0003091_abnormal_cell_migration0.73517257
128MP0000759_abnormal_skeletal_muscle0.73505049
129MP0000613_abnormal_salivary_gland0.73109665
130MP0002098_abnormal_vibrissa_morphology0.72847850
131MP0004883_abnormal_blood_vessel0.72141804
132MP0002177_abnormal_outer_ear0.70993883
133MP0002060_abnormal_skin_morphology0.70845332
134MP0005334_abnormal_fat_pad0.70298342
135MP0005621_abnormal_cell_physiology0.70184168
136MP0005646_abnormal_pituitary_gland0.69801686
137MP0001191_abnormal_skin_condition0.69290244

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)3.96122693
2Eczematoid dermatitis (HP:0000976)3.86914739
3Abnormality of the fingertips (HP:0001211)3.14780630
4Optic neuritis (HP:0100653)3.13738893
5Retrobulbar optic neuritis (HP:0100654)3.13738893
6Obstructive sleep apnea (HP:0002870)2.93445402
7Myositis (HP:0100614)2.91021650
8Aortic aneurysm (HP:0004942)2.90002328
9Broad face (HP:0000283)2.89430624
10Orchitis (HP:0100796)2.88865536
11Mediastinal lymphadenopathy (HP:0100721)2.88829064
12Recurrent abscess formation (HP:0002722)2.87059065
13Syringomyelia (HP:0003396)2.73702504
14Spinal cord lesions (HP:0100561)2.73702504
15Colitis (HP:0002583)2.71520080
16Pustule (HP:0200039)2.69248230
17Pulmonary artery stenosis (HP:0004415)2.67440763
18Abnormality of macrophages (HP:0004311)2.66857048
19Cerebral aneurysm (HP:0004944)2.65008699
20Recurrent fungal infections (HP:0002841)2.64277830
21Broad metatarsal (HP:0001783)2.55845441
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55434290
23T lymphocytopenia (HP:0005403)2.50903277
24Protrusio acetabuli (HP:0003179)2.50589615
25Segmental peripheral demyelination/remyelination (HP:0003481)2.48358907
26Abnormality of T cell number (HP:0011839)2.45477016
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.43272647
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.42168716
29Gingivitis (HP:0000230)2.40644963
30Panhypogammaglobulinemia (HP:0003139)2.39266899
31Dislocated radial head (HP:0003083)2.38118806
32Prolonged bleeding time (HP:0003010)2.37262446
33Agammaglobulinemia (HP:0004432)2.36702140
34Abnormality of the nasal septum (HP:0000419)2.34236383
35Papilledema (HP:0001085)2.33710004
36Subaortic stenosis (HP:0001682)2.33420325
37Abnormality of the left ventricular outflow tract (HP:0011103)2.33420325
38Chromsome breakage (HP:0040012)2.32496484
39Gastrointestinal inflammation (HP:0004386)2.30806733
40Follicular hyperkeratosis (HP:0007502)2.26175495
41Recurrent bacterial skin infections (HP:0005406)2.25646602
42Lip pit (HP:0100267)2.25344784
43Recurrent cutaneous fungal infections (HP:0011370)2.24964537
44Chronic mucocutaneous candidiasis (HP:0002728)2.24964537
45Abnormality of the radial head (HP:0003995)2.23129278
46Obstructive lung disease (HP:0006536)2.22834310
47Chronic obstructive pulmonary disease (HP:0006510)2.22834310
48Gastrointestinal infarctions (HP:0005244)2.22696874
49Emphysema (HP:0002097)2.20944976
50Dysostosis multiplex (HP:0000943)2.19514316
51Abnormality of the prostate (HP:0008775)2.19120156
52Persistence of primary teeth (HP:0006335)2.18558761
53Pulmonary infiltrates (HP:0002113)2.17747291
54Aneurysm (HP:0002617)2.14390031
55Gastrointestinal stroma tumor (HP:0100723)2.13722027
56Verrucae (HP:0200043)2.12773944
57Papilloma (HP:0012740)2.12773944
58Recurrent gram-negative bacterial infections (HP:0005420)2.12534186
59Dilatation of the ascending aorta (HP:0005111)2.09582642
60Mitral regurgitation (HP:0001653)2.08651711
61Hemoptysis (HP:0002105)2.07979968
62Asymmetric septal hypertrophy (HP:0001670)2.07939472
63Slow saccadic eye movements (HP:0000514)2.06240351
64Spontaneous hematomas (HP:0007420)2.06087094
65Abnormality of polysaccharide metabolism (HP:0011012)2.05756653
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05756653
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05756653
68Urinary glycosaminoglycan excretion (HP:0003541)2.03984081
69Mucopolysacchariduria (HP:0008155)2.03984081
70Aplasia cutis congenita (HP:0001057)2.03555103
71Vasculitis (HP:0002633)2.02803293
72Keratoconjunctivitis sicca (HP:0001097)2.02437239
73Stomach cancer (HP:0012126)2.02420860
74Submucous cleft hard palate (HP:0000176)2.01638324
75Stomatitis (HP:0010280)2.00823972
76Meningitis (HP:0001287)1.99892468
77Cheilitis (HP:0100825)1.99849064
78Abnormality of male internal genitalia (HP:0000022)1.99051182
79Gingival bleeding (HP:0000225)1.98503576
80Congenital stationary night blindness (HP:0007642)1.98453930
81Chronic otitis media (HP:0000389)1.97921481
82Thin bony cortex (HP:0002753)1.97918051
83Arterial thrombosis (HP:0004420)1.97015038
84Abnormality of T cells (HP:0002843)1.96386755
85Aortic dissection (HP:0002647)1.96277862
86Increased variability in muscle fiber diameter (HP:0003557)1.95712277
87Eosinophilia (HP:0001880)1.95404810
88Chronic sinusitis (HP:0011109)1.94316030
89Onion bulb formation (HP:0003383)1.93915377
90Mitral valve prolapse (HP:0001634)1.91715427
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90291070
92Spondylolisthesis (HP:0003302)1.88472180
93Chronic diarrhea (HP:0002028)1.88243745
94Malnutrition (HP:0004395)1.87812412
95Keratitis (HP:0000491)1.87491620
96Recurrent sinusitis (HP:0011108)1.87210934
97Increased IgE level (HP:0003212)1.85652236
98Autoimmune hemolytic anemia (HP:0001890)1.85206407
99Recurrent bronchitis (HP:0002837)1.84291531
100Keratoconjunctivitis (HP:0001096)1.82226181
101Petechiae (HP:0000967)1.81871771
102Restrictive lung disease (HP:0002091)1.81753710
103Mesomelia (HP:0003027)1.81025550
104Craniofacial hyperostosis (HP:0004493)1.80252707
105Trigonocephaly (HP:0000243)1.79564763
106Recurrent skin infections (HP:0001581)1.79514209
107Narrow palate (HP:0000189)1.77451255
108Absent frontal sinuses (HP:0002688)1.76912004
109Abnormality of the columella (HP:0009929)1.76815698
110Cervical subluxation (HP:0003308)1.76587930
111Thoracic kyphosis (HP:0002942)1.75474233
112Elevated erythrocyte sedimentation rate (HP:0003565)1.75214546
113Hypoplasia of the iris (HP:0007676)1.74941888
114Hematochezia (HP:0002573)1.74375796
115Hypercortisolism (HP:0001578)1.73877209
116Leukocytosis (HP:0001974)1.73188681
117Annular pancreas (HP:0001734)1.72753422
118Epistaxis (HP:0000421)1.72610289
119Lymphopenia (HP:0001888)1.72216520
120Disproportionate tall stature (HP:0001519)1.72150637
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72063506
122Recurrent pneumonia (HP:0006532)1.72063248
123Chest pain (HP:0100749)1.71121134
124Periodontitis (HP:0000704)1.70832262
125Glomerulopathy (HP:0100820)1.70510818
126Sparse lateral eyebrow (HP:0005338)1.69890905
127Spinal canal stenosis (HP:0003416)1.69786157
128Abnormal sex determination (HP:0012244)1.69450910
129Sex reversal (HP:0012245)1.69450910
130Vertebral compression fractures (HP:0002953)1.69153596
131Increased connective tissue (HP:0009025)1.68570952
132Ectopic kidney (HP:0000086)1.68104539
133Interstitial pulmonary disease (HP:0006530)1.67861464
134Osteomyelitis (HP:0002754)1.67789767
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.67155146
136Abnormal ciliary motility (HP:0012262)1.65574508
137Deformed sella turcica (HP:0002681)1.65337952
138Fatigue (HP:0012378)1.64647952
139Long eyelashes (HP:0000527)1.63591599
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.62448983
141Abnormal respiratory motile cilium physiology (HP:0012261)1.62431249
142Abnormality of the pleura (HP:0002103)1.62188910
143Unilateral renal agenesis (HP:0000122)1.61835561
144Distal lower limb amyotrophy (HP:0008944)1.61717862
145Albinism (HP:0001022)1.61544068
146Abnormality of the endocardium (HP:0004306)1.61236256
147Joint hemorrhage (HP:0005261)1.60862626
148Bruising susceptibility (HP:0000978)1.60577743
149Granulocytopenia (HP:0001913)1.60447377
150Cellulitis (HP:0100658)1.60063821
151Febrile seizures (HP:0002373)1.59933241
152Acute myeloid leukemia (HP:0004808)1.58920946
153White forelock (HP:0002211)1.58601253
154Cranial hyperostosis (HP:0004437)1.56413859
155Recurrent viral infections (HP:0004429)1.55274752
156Abnormality of DNA repair (HP:0003254)1.54769561
157Autoimmune thrombocytopenia (HP:0001973)1.54763758
158Abnormality of the thoracic spine (HP:0100711)1.53981045
159Abnormality of eosinophils (HP:0001879)1.53872778
160Abnormality of incisor morphology (HP:0011063)1.53707379
161Ectropion (HP:0000656)1.53542994
162Inflammation of the large intestine (HP:0002037)1.53315512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.42164166
2MAP3K142.99576009
3TRIB32.72851862
4INSRR2.70634441
5IRAK32.41897759
6TNIK2.38797416
7PRPF4B2.37194884
8NLK2.28424497
9MAP3K132.17537885
10BRD42.15447404
11MAP4K12.06956808
12ICK2.05354167
13JAK11.94706781
14ZAK1.93991952
15SIK31.87675417
16JAK31.84680779
17EPHB11.76246864
18EPHA31.73353831
19TEC1.57156151
20IRAK41.53707277
21FGFR41.49058971
22TNK21.47965499
23CDK121.47380619
24GRK61.46281523
25RIPK11.45180792
26CLK11.44604495
27MAP3K101.39754563
28TYK21.39109914
29KIT1.35940168
30TIE11.35688175
31BTK1.35601547
32TAOK31.35408454
33SIK21.35245380
34IKBKE1.35037842
35DMPK1.34828727
36IKBKB1.33141701
37ITK1.26900909
38NUAK11.26270312
39CHUK1.24490702
40CAMK1G1.24485877
41HCK1.23041760
42MAPK71.22997376
43FGFR31.22536791
44CAMKK11.21240184
45MAPK111.19078027
46SIK11.17192937
47CAMKK21.15862412
48PKN11.14585734
49TBK11.11270375
50SMG11.05242609
51TRPM71.04896322
52GRK11.04529058
53BMX1.03375468
54BLK1.01549313
55CAMK1D0.98085082
56MTOR0.94846329
57MAP2K70.94481310
58MAP3K10.94299650
59PDK10.93536883
60CAMK10.92713610
61IRAK10.90809991
62STK380.90200525
63CSK0.90174263
64TESK20.89942064
65MAP3K70.89445352
66TYRO30.89044728
67PDGFRA0.88889860
68MAP3K30.88530071
69PDPK10.85577403
70SGK20.84527732
71YES10.84118852
72TGFBR20.82437173
73PRKD20.81015153
74ZAP700.80027055
75HIPK20.79047899
76CDK30.78594410
77MAPK150.77749540
78PTK60.76490280
79CDK90.75744691
80SYK0.75529388
81MARK30.75347953
82EIF2AK20.74885201
83PRKCH0.74352308
84PKN20.72846607
85RPS6KA60.72105610
86ERN10.72105478
87SGK30.71850543
88MAP2K20.71512020
89TAOK20.70004462
90RET0.69705604
91MELK0.68119814
92PDK20.67959632
93LCK0.67250647
94MARK20.65723510
95RPS6KL10.63860300
96RPS6KC10.63860300
97RIPK40.63419595
98RPS6KA20.62628761
99MKNK20.62295841
100LYN0.61858893
101TAOK10.61849641
102PINK10.61030572
103CDK40.60662238
104ERBB30.58147980
105CAMK40.57895488
106LRRK20.57344316
107JAK20.57118615
108CSF1R0.56566515
109STK30.56486349
110BMPR20.55154753
111MAP3K110.52735609
112NEK90.52432949
113ABL10.52170620
114EEF2K0.52095878
115PDGFRB0.52013768
116WNK10.51348677
117NEK60.50761345
118CDC42BPA0.50743847
119MAP3K60.50579412
120MAPK40.50502002
121STK110.50001560
122FES0.49707494
123PRKCQ0.49213864
124TTN0.48684160
125AKT30.48643433
126PIK3CG0.47988984
127MAPK120.47616921
128PRKAA20.46701544
129PIM10.46601037
130STK240.45735820
131LATS10.45633570
132STK40.45454923
133MAPK30.41331374
134PRKCE0.36172319
135MAPKAPK20.36002128
136MAP2K30.35658334

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42997477
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.22570302
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.00268938
4Leishmaniasis_Homo sapiens_hsa051401.99500728
5Hematopoietic cell lineage_Homo sapiens_hsa046401.86740564
6Primary immunodeficiency_Homo sapiens_hsa053401.86244667
7Osteoclast differentiation_Homo sapiens_hsa043801.79496923
8Graft-versus-host disease_Homo sapiens_hsa053321.75388883
9Measles_Homo sapiens_hsa051621.71713781
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66681085
11Non-small cell lung cancer_Homo sapiens_hsa052231.60222530
12Jak-STAT signaling pathway_Homo sapiens_hsa046301.55677750
13Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53963875
14Allograft rejection_Homo sapiens_hsa053301.51324881
15TNF signaling pathway_Homo sapiens_hsa046681.51248992
16Malaria_Homo sapiens_hsa051441.48842983
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39657831
18VEGF signaling pathway_Homo sapiens_hsa043701.37103774
19Toxoplasmosis_Homo sapiens_hsa051451.34123359
20mTOR signaling pathway_Homo sapiens_hsa041501.33228624
21T cell receptor signaling pathway_Homo sapiens_hsa046601.31339674
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29025107
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28868715
24Chemokine signaling pathway_Homo sapiens_hsa040621.27238971
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26990181
26Autoimmune thyroid disease_Homo sapiens_hsa053201.26548406
27Renal cell carcinoma_Homo sapiens_hsa052111.25787732
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22125839
29B cell receptor signaling pathway_Homo sapiens_hsa046621.21692910
30Viral myocarditis_Homo sapiens_hsa054161.20919730
31Endometrial cancer_Homo sapiens_hsa052131.19744161
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14681769
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14012649
34Vitamin digestion and absorption_Homo sapiens_hsa049771.13946702
35Asthma_Homo sapiens_hsa053101.12690627
36Dilated cardiomyopathy_Homo sapiens_hsa054141.12151773
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09182498
38Choline metabolism in cancer_Homo sapiens_hsa052311.07987707
39Herpes simplex infection_Homo sapiens_hsa051681.07555235
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07148144
41Influenza A_Homo sapiens_hsa051641.07106352
42Hepatitis B_Homo sapiens_hsa051611.06064438
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05989267
44Acute myeloid leukemia_Homo sapiens_hsa052211.03724054
45Tuberculosis_Homo sapiens_hsa051521.00601927
46Dorso-ventral axis formation_Homo sapiens_hsa043201.00011659
47Lysine degradation_Homo sapiens_hsa003100.99048363
48ECM-receptor interaction_Homo sapiens_hsa045120.97876791
49GnRH signaling pathway_Homo sapiens_hsa049120.97533447
50Adherens junction_Homo sapiens_hsa045200.97247076
51Staphylococcus aureus infection_Homo sapiens_hsa051500.96794549
52Notch signaling pathway_Homo sapiens_hsa043300.95348983
53Small cell lung cancer_Homo sapiens_hsa052220.94790347
54Colorectal cancer_Homo sapiens_hsa052100.94744129
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93550708
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93356365
57Ovarian steroidogenesis_Homo sapiens_hsa049130.92753042
58Circadian rhythm_Homo sapiens_hsa047100.92089607
59ErbB signaling pathway_Homo sapiens_hsa040120.91539667
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.91217679
61Platelet activation_Homo sapiens_hsa046110.90463055
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89855674
63Prolactin signaling pathway_Homo sapiens_hsa049170.89024201
64Apoptosis_Homo sapiens_hsa042100.84982208
65Chronic myeloid leukemia_Homo sapiens_hsa052200.84693941
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84074922
67Glioma_Homo sapiens_hsa052140.82699291
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82226431
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.81466094
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80470494
71* HTLV-I infection_Homo sapiens_hsa051660.80161997
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79397633
73ABC transporters_Homo sapiens_hsa020100.78547536
74Focal adhesion_Homo sapiens_hsa045100.78544547
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77891745
76Insulin signaling pathway_Homo sapiens_hsa049100.77635429
77Type II diabetes mellitus_Homo sapiens_hsa049300.76481904
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76255795
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.75763939
80Rheumatoid arthritis_Homo sapiens_hsa053230.75752401
81Other glycan degradation_Homo sapiens_hsa005110.75649032
82Prostate cancer_Homo sapiens_hsa052150.74772821
83Phototransduction_Homo sapiens_hsa047440.72633057
84Pancreatic cancer_Homo sapiens_hsa052120.71888870
85Pertussis_Homo sapiens_hsa051330.71760700
86FoxO signaling pathway_Homo sapiens_hsa040680.71241199
87Amoebiasis_Homo sapiens_hsa051460.70920031
88Thyroid cancer_Homo sapiens_hsa052160.70825469
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69503923
90Type I diabetes mellitus_Homo sapiens_hsa049400.68751410
91Endocytosis_Homo sapiens_hsa041440.68684978
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.68335690
93Long-term potentiation_Homo sapiens_hsa047200.67558584
94cAMP signaling pathway_Homo sapiens_hsa040240.66944550
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66906219
96Estrogen signaling pathway_Homo sapiens_hsa049150.66663493
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66223736
98Arachidonic acid metabolism_Homo sapiens_hsa005900.65684711
99Antigen processing and presentation_Homo sapiens_hsa046120.65063315
100MAPK signaling pathway_Homo sapiens_hsa040100.64978828
101Insulin resistance_Homo sapiens_hsa049310.64967437
102African trypanosomiasis_Homo sapiens_hsa051430.64914798
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63974862
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63762583
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63376862
106Pathways in cancer_Homo sapiens_hsa052000.61360171
107Salmonella infection_Homo sapiens_hsa051320.60860827
108Rap1 signaling pathway_Homo sapiens_hsa040150.60406025
109Hepatitis C_Homo sapiens_hsa051600.60301758
110MicroRNAs in cancer_Homo sapiens_hsa052060.59779629
111Viral carcinogenesis_Homo sapiens_hsa052030.59508927
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59193391
113Proteoglycans in cancer_Homo sapiens_hsa052050.58572841
114Lysosome_Homo sapiens_hsa041420.58230074
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57883482
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57835681
117AMPK signaling pathway_Homo sapiens_hsa041520.57472510
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56642372
119Oxytocin signaling pathway_Homo sapiens_hsa049210.56209501
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56081535
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55633808
122HIF-1 signaling pathway_Homo sapiens_hsa040660.55629461
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55321064
124Legionellosis_Homo sapiens_hsa051340.55160152
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.55075909
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54954875
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54193578
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53139038
129Inositol phosphate metabolism_Homo sapiens_hsa005620.52981692
130Sphingolipid metabolism_Homo sapiens_hsa006000.52830379
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.50509714
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.48396025

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