CRX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phototransduction (GO:0007602)9.08886542
2GMP metabolic process (GO:0046037)9.02787005
3detection of light stimulus (GO:0009583)8.85198059
4phototransduction, visible light (GO:0007603)8.55736808
5detection of visible light (GO:0009584)8.47966280
6* visual perception (GO:0007601)8.20756674
7* sensory perception of light stimulus (GO:0050953)8.12296080
8photoreceptor cell differentiation (GO:0046530)7.87394254
9eye photoreceptor cell differentiation (GO:0001754)7.87394254
10protein-chromophore linkage (GO:0018298)6.58456330
11* retina development in camera-type eye (GO:0060041)6.38447835
12detection of external stimulus (GO:0009581)6.22665708
13behavioral response to nicotine (GO:0035095)6.21662734
14cellular response to light stimulus (GO:0071482)6.13732650
15detection of abiotic stimulus (GO:0009582)6.11542544
16positive regulation of guanylate cyclase activity (GO:0031284)5.98811061
17regulation of guanylate cyclase activity (GO:0031282)5.36865777
18regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.30013458
19peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.29847961
20nonmotile primary cilium assembly (GO:0035058)5.15911368
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04700529
22L-fucose catabolic process (GO:0042355)4.37303291
23fucose catabolic process (GO:0019317)4.37303291
24L-fucose metabolic process (GO:0042354)4.37303291
25regulation of clathrin-mediated endocytosis (GO:2000369)4.36584063
26regulation of cGMP metabolic process (GO:0030823)4.34331774
27regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31525386
28retina layer formation (GO:0010842)4.24981556
29neuron development (GO:0048666)4.14283327
30protein localization to synapse (GO:0035418)4.11529510
31DNA deamination (GO:0045006)4.05868565
32* sensory perception (GO:0007600)3.95475782
33response to pheromone (GO:0019236)3.94372530
34cellular response to radiation (GO:0071478)3.91888897
35positive regulation of cGMP biosynthetic process (GO:0030828)3.79948066
36water-soluble vitamin biosynthetic process (GO:0042364)3.67361614
37platelet dense granule organization (GO:0060155)3.64141013
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.62005612
39cellular potassium ion homeostasis (GO:0030007)3.60669026
40negative regulation of telomere maintenance (GO:0032205)3.57889801
41regulation of cGMP biosynthetic process (GO:0030826)3.54251670
42synaptic vesicle maturation (GO:0016188)3.53131561
43response to light stimulus (GO:0009416)3.52406118
44adaptation of signaling pathway (GO:0023058)3.52263215
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.50348140
46negative regulation of receptor-mediated endocytosis (GO:0048261)3.47407351
47positive regulation of gastrulation (GO:2000543)3.44952261
48indolalkylamine metabolic process (GO:0006586)3.44519476
49regulation of voltage-gated calcium channel activity (GO:1901385)3.42251283
50regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.40988580
51protein-cofactor linkage (GO:0018065)3.40583575
52axoneme assembly (GO:0035082)3.38630724
53indole-containing compound catabolic process (GO:0042436)3.36983643
54indolalkylamine catabolic process (GO:0046218)3.36983643
55tryptophan catabolic process (GO:0006569)3.36983643
56piRNA metabolic process (GO:0034587)3.35640141
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32576728
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32576728
59potassium ion homeostasis (GO:0055075)3.31185668
60positive regulation of cGMP metabolic process (GO:0030825)3.30541728
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29857075
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.29857075
63NADH dehydrogenase complex assembly (GO:0010257)3.29857075
64neuron remodeling (GO:0016322)3.29432557
65cellular ketone body metabolic process (GO:0046950)3.27452596
66estrogen biosynthetic process (GO:0006703)3.27056029
67protein complex biogenesis (GO:0070271)3.25140522
68synaptic vesicle docking involved in exocytosis (GO:0016081)3.23151877
69membrane hyperpolarization (GO:0060081)3.18269842
70kynurenine metabolic process (GO:0070189)3.14569163
71positive regulation of oligodendrocyte differentiation (GO:0048714)3.14257903
72cell morphogenesis involved in neuron differentiation (GO:0048667)3.13114350
73kidney morphogenesis (GO:0060993)3.11904810
74appendage development (GO:0048736)3.10699602
75limb development (GO:0060173)3.10699602
76histone H3-K4 trimethylation (GO:0080182)3.09567057
77sodium ion export (GO:0071436)3.04991253
78protein polyglutamylation (GO:0018095)3.04467373
79respiratory chain complex IV assembly (GO:0008535)3.03031729
80preassembly of GPI anchor in ER membrane (GO:0016254)2.99966092
81mitochondrial respiratory chain complex assembly (GO:0033108)2.98601080
82receptor guanylyl cyclase signaling pathway (GO:0007168)2.96181697
83prenylation (GO:0097354)2.94133603
84protein prenylation (GO:0018342)2.94133603
85positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.93841168
86ketone body metabolic process (GO:1902224)2.92925221
87tryptophan metabolic process (GO:0006568)2.91992009
88pseudouridine synthesis (GO:0001522)2.91809551
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91057839
90gamma-aminobutyric acid transport (GO:0015812)2.90869579
91negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.90699568
92cornea development in camera-type eye (GO:0061303)2.89662551
93synaptic vesicle exocytosis (GO:0016079)2.87855645
94DNA methylation involved in gamete generation (GO:0043046)2.86615784
95epithelial cilium movement (GO:0003351)2.85830300
96retina homeostasis (GO:0001895)2.82044205
97sulfation (GO:0051923)2.80888939
98positive regulation of vesicle fusion (GO:0031340)2.79836500
99neuron fate determination (GO:0048664)2.79055597
100indole-containing compound metabolic process (GO:0042430)2.78836349
101nephron epithelium morphogenesis (GO:0072088)2.78107430
102nephron tubule morphogenesis (GO:0072078)2.78107430
103mannosylation (GO:0097502)2.76897856
104regulation of synaptic vesicle exocytosis (GO:2000300)2.76862505
105positive regulation of sodium ion transmembrane transport (GO:1902307)2.76827534
106detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.76475925
107somite rostral/caudal axis specification (GO:0032525)2.74256564
108innervation (GO:0060384)2.72555886
109adenosine metabolic process (GO:0046085)2.71848717
110synaptic transmission, cholinergic (GO:0007271)2.71483703
111primary amino compound metabolic process (GO:1901160)2.70202787
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69657411
113reflex (GO:0060004)2.69445101
114tRNA modification (GO:0006400)2.68561355
115positive regulation of neurotransmitter transport (GO:0051590)2.68392930
116glycerophospholipid catabolic process (GO:0046475)2.68115596
117negative regulation of mast cell activation (GO:0033004)2.68017327
118amine catabolic process (GO:0009310)2.67250213
119cellular biogenic amine catabolic process (GO:0042402)2.67250213
120regulation of nuclear cell cycle DNA replication (GO:0033262)2.66663604
121L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66118407
122neuronal action potential (GO:0019228)2.64169791
123tRNA processing (GO:0008033)2.64105318
124regulation of type B pancreatic cell apoptotic process (GO:2000674)2.62711517
125regulation of cilium movement (GO:0003352)2.61756748
126lipid translocation (GO:0034204)2.61615708
127phospholipid translocation (GO:0045332)2.61615708
128regulation of action potential (GO:0098900)2.60757523
129cilium morphogenesis (GO:0060271)2.60630406
130auditory receptor cell stereocilium organization (GO:0060088)2.59867088
131multicellular organism reproduction (GO:0032504)2.58755107
132cytochrome complex assembly (GO:0017004)2.58411563
133lipoprotein transport (GO:0042953)2.57574623
134lactate metabolic process (GO:0006089)2.53588018
135primitive streak formation (GO:0090009)2.50503811
136protein localization to cilium (GO:0061512)2.49728099
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49304817
138positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.48338279
139regulation of neurotransmitter uptake (GO:0051580)2.48275901
140ubiquinone biosynthetic process (GO:0006744)2.47900674
141somite development (GO:0061053)2.46765915
142regulation of mesoderm development (GO:2000380)2.45686568
143positive regulation of fatty acid transport (GO:2000193)2.45620555
144GPI anchor metabolic process (GO:0006505)2.45501518
145cilium or flagellum-dependent cell motility (GO:0001539)2.45425679
146negative regulation of DNA-dependent DNA replication (GO:2000104)2.43979432
147phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43940584
148mitochondrial RNA metabolic process (GO:0000959)2.43242368
149L-methionine salvage (GO:0071267)2.43236647
150L-methionine biosynthetic process (GO:0071265)2.43236647
151amino acid salvage (GO:0043102)2.43236647
152neural tube formation (GO:0001841)2.42897024
153cilium organization (GO:0044782)2.42694763
154regulation of vesicle fusion (GO:0031338)2.42590703
155replication fork processing (GO:0031297)2.42235832
156cellular response to ATP (GO:0071318)2.40555218
157retinoid metabolic process (GO:0001523)2.39950494
158recombinational repair (GO:0000725)2.39502481
159regulation of synaptic vesicle transport (GO:1902803)2.39360600
160dentate gyrus development (GO:0021542)2.39059545
161potassium ion import (GO:0010107)2.38244226
162negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38018319
163adult feeding behavior (GO:0008343)2.37258735
164response to radiation (GO:0009314)2.37215221
165double-strand break repair via homologous recombination (GO:0000724)2.37061290
166regulation of hippo signaling (GO:0035330)2.36212123
167S-adenosylmethionine metabolic process (GO:0046500)2.36083914
168cilium movement (GO:0003341)2.36010762
169ubiquinone metabolic process (GO:0006743)2.35784553
170behavioral response to ethanol (GO:0048149)2.35506032
171calcium ion import (GO:0070509)2.32349597
172establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.31426133
173mitochondrion transport along microtubule (GO:0047497)2.31426133
174righting reflex (GO:0060013)2.31290612
175regulation of neurotransmitter secretion (GO:0046928)2.31150257
176G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30435484
177CDP-diacylglycerol biosynthetic process (GO:0016024)2.28109738
178positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.26725593
179regulation of rhodopsin mediated signaling pathway (GO:0022400)14.0573572
180rhodopsin mediated signaling pathway (GO:0016056)13.7574336
181photoreceptor cell development (GO:0042461)12.9500035
182retinal cone cell development (GO:0046549)12.9066005
183photoreceptor cell maintenance (GO:0045494)12.4803430
184eye photoreceptor cell development (GO:0042462)12.4197084
185retinal rod cell development (GO:0046548)12.3559538
186detection of light stimulus involved in visual perception (GO:0050908)10.2652152
187detection of light stimulus involved in sensory perception (GO:0050962)10.2652152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.24664776
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.26247127
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23627087
4GBX2_23144817_ChIP-Seq_PC3_Human3.17358073
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.03932624
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03174593
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.83875406
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43779008
9DROSHA_22980978_ChIP-Seq_HELA_Human2.25790476
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24039452
11EWS_26573619_Chip-Seq_HEK293_Human2.14671270
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.12022944
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.06094220
14FUS_26573619_Chip-Seq_HEK293_Human2.02575715
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01283369
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99127012
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99106727
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95786641
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.93129463
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92736037
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91544950
22REST_21632747_ChIP-Seq_MESCs_Mouse1.91004496
23P53_22127205_ChIP-Seq_FIBROBLAST_Human1.90070980
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89908758
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87535467
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87062603
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84537854
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83406032
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79074907
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78362915
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78362915
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73900393
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73689426
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.72823648
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.72782892
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71238806
37TAF15_26573619_Chip-Seq_HEK293_Human1.69387744
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65749887
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.65662880
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.65254236
41IRF1_19129219_ChIP-ChIP_H3396_Human1.64156355
42TP53_22573176_ChIP-Seq_HFKS_Human1.61851841
43* REST_18959480_ChIP-ChIP_MESCs_Mouse1.60953834
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53235590
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.52102401
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.52024822
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.50472621
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49623961
49TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.48970834
50MYC_18940864_ChIP-ChIP_HL60_Human1.47387208
51SMAD3_21741376_ChIP-Seq_HESCs_Human1.46202377
52SMAD4_21799915_ChIP-Seq_A2780_Human1.46072328
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44611086
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.43205224
55AR_21572438_ChIP-Seq_LNCaP_Human1.43095273
56* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42340887
57AR_19668381_ChIP-Seq_PC3_Human1.42011933
58NANOG_19829295_ChIP-Seq_ESCs_Human1.39797893
59SOX2_19829295_ChIP-Seq_ESCs_Human1.39797893
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39783529
61VDR_22108803_ChIP-Seq_LS180_Human1.39095210
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38835738
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38359930
64KDM2B_26808549_Chip-Seq_K562_Human1.36521749
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35769944
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34546459
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34266861
68TCF4_22108803_ChIP-Seq_LS180_Human1.33845209
69TBL1_22424771_ChIP-Seq_293T_Human1.33067303
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32707195
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.32707195
72AR_25329375_ChIP-Seq_VCAP_Human1.31534525
73STAT3_23295773_ChIP-Seq_U87_Human1.31277073
74CTCF_27219007_Chip-Seq_Bcells_Human1.29913705
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29772818
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27841971
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27743588
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.27580410
79IGF1R_20145208_ChIP-Seq_DFB_Human1.27291268
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26904200
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26846171
82BCAT_22108803_ChIP-Seq_LS180_Human1.26844197
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.26459410
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26383322
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.26156543
86NCOR_22424771_ChIP-Seq_293T_Human1.26123581
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25691454
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.25109106
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24470437
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.24255217
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22381113
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.21361201
93P300_19829295_ChIP-Seq_ESCs_Human1.20030502
94RUNX2_22187159_ChIP-Seq_PCA_Human1.19624475
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19012468
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18946899
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18200920
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17687534
99EZH2_22144423_ChIP-Seq_EOC_Human1.17672330
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.16718303
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16029688
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.15350275
103AR_20517297_ChIP-Seq_VCAP_Human1.14359772
104* HOXB7_26014856_ChIP-Seq_BT474_Human1.13832957
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13563104
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12364435
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.11368465
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11133144
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10404927
110TCF4_23295773_ChIP-Seq_U87_Human1.10144110
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09553491
112ISL1_27105846_Chip-Seq_CPCs_Mouse1.09425218
113ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09336303
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09271410
115RNF2_27304074_Chip-Seq_NSC_Mouse1.08649363
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08482047
117VDR_23849224_ChIP-Seq_CD4+_Human1.08175304
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.07327610
119CBP_20019798_ChIP-Seq_JUKART_Human1.06840968
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06840968
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.06541407
122SALL1_21062744_ChIP-ChIP_HESCs_Human1.05602382
123WDR5_24793694_ChIP-Seq_LNCAP_Human1.05560990
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05339834
125CDX2_22108803_ChIP-Seq_LS180_Human1.05307243
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.04639448
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04634109
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04440055
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04386116
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03559335
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03444269
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03228121
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02959045
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.02666606
135ER_23166858_ChIP-Seq_MCF-7_Human1.01918339
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01463541
137MYC_19829295_ChIP-Seq_ESCs_Human1.01451344
138CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00956177
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00888099
140SMAD4_21741376_ChIP-Seq_HESCs_Human1.00508277
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00354592
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99675003
143AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99404483
144P53_22387025_ChIP-Seq_ESCs_Mouse0.99190870
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99143241
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97198802
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97198802
148ELK1_19687146_ChIP-ChIP_HELA_Human0.96696886
149SMC4_20622854_ChIP-Seq_HELA_Human0.96092850
150AHR_22903824_ChIP-Seq_MCF-7_Human0.95935070
151* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95563156
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.94885262
153NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94458277
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94275278
155STAT3_18555785_Chip-Seq_ESCs_Mouse0.94120406
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.93912422
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.93769424
158FOXH1_21741376_ChIP-Seq_EPCs_Human0.93538902
159WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93482146
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91998891
161CBP_21632823_ChIP-Seq_H3396_Human0.91488192
162SOX2_21211035_ChIP-Seq_LN229_Gbm0.90830668
163SMAD3_21741376_ChIP-Seq_ESCs_Human0.89883715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.16106861
2MP0003011_delayed_dark_adaptation8.27876533
3MP0006072_abnormal_retinal_apoptosis7.02333445
4MP0005253_abnormal_eye_physiology6.53140974
5* MP0005195_abnormal_posterior_eye4.07082372
6MP0003950_abnormal_plasma_membrane3.84625381
7MP0001324_abnormal_eye_pigmentation3.68943669
8MP0005391_vision/eye_phenotype3.38055129
9MP0006292_abnormal_olfactory_placode3.21631871
10MP0002638_abnormal_pupillary_reflex3.13487123
11MP0003195_calcinosis3.06496798
12MP0008877_abnormal_DNA_methylation2.74997066
13MP0002090_abnormal_vision2.61862244
14* MP0002229_neurodegeneration2.53976500
15MP0002653_abnormal_ependyma_morphology2.53028409
16MP0002736_abnormal_nociception_after2.27180173
17MP0008872_abnormal_physiological_respon2.23050870
18MP0004147_increased_porphyrin_level2.14854350
19* MP0002752_abnormal_somatic_nervous2.10337840
20MP0003646_muscle_fatigue2.08807802
21MP0002837_dystrophic_cardiac_calcinosis2.05902615
22MP0005423_abnormal_somatic_nervous2.02576654
23MP0002876_abnormal_thyroid_physiology1.97711381
24MP0000569_abnormal_digit_pigmentation1.88772206
25MP0005394_taste/olfaction_phenotype1.88443511
26MP0005499_abnormal_olfactory_system1.88443511
27MP0008789_abnormal_olfactory_epithelium1.85483069
28MP0010030_abnormal_orbit_morphology1.77350082
29MP0004133_heterotaxia1.76662116
30MP0004885_abnormal_endolymph1.74757895
31MP0008875_abnormal_xenobiotic_pharmacok1.67151947
32MP0000427_abnormal_hair_cycle1.62848914
33MP0001501_abnormal_sleep_pattern1.62055123
34MP0005645_abnormal_hypothalamus_physiol1.59934269
35MP0002938_white_spotting1.57518272
36* MP0002882_abnormal_neuron_morphology1.54917906
37MP0001485_abnormal_pinna_reflex1.51418091
38MP0001984_abnormal_olfaction1.51342904
39MP0001764_abnormal_homeostasis1.51138038
40MP0000372_irregular_coat_pigmentation1.50340303
41MP0005084_abnormal_gallbladder_morpholo1.47237040
42MP0002160_abnormal_reproductive_system1.45448834
43* MP0001502_abnormal_circadian_rhythm1.43784883
44MP0002735_abnormal_chemical_nociception1.39762788
45MP0006276_abnormal_autonomic_nervous1.38292543
46MP0002163_abnormal_gland_morphology1.35145149
47MP0005389_reproductive_system_phenotype1.31794935
48MP0005248_abnormal_Harderian_gland1.30857580
49MP0005167_abnormal_blood-brain_barrier1.26781884
50MP0002095_abnormal_skin_pigmentation1.26042833
51MP0008995_early_reproductive_senescence1.25047051
52MP0005379_endocrine/exocrine_gland_phen1.23970327
53MP0003890_abnormal_embryonic-extraembry1.15985108
54MP0001986_abnormal_taste_sensitivity1.14998688
55MP0002234_abnormal_pharynx_morphology1.12796264
56MP0001905_abnormal_dopamine_level1.12337591
57MP0005197_abnormal_uvea_morphology1.11480312
58MP0002733_abnormal_thermal_nociception1.11425200
59MP0002138_abnormal_hepatobiliary_system1.10859464
60MP0001970_abnormal_pain_threshold1.09621412
61MP0001486_abnormal_startle_reflex1.09199270
62MP0003136_yellow_coat_color1.08204598
63MP0005075_abnormal_melanosome_morpholog1.06500876
64MP0005174_abnormal_tail_pigmentation1.05061334
65MP0003880_abnormal_central_pattern1.04537974
66MP0001919_abnormal_reproductive_system1.02132089
67MP0001529_abnormal_vocalization1.01271094
68MP0002127_abnormal_cardiovascular_syste0.99998506
69MP0000230_abnormal_systemic_arterial0.97856435
70MP0004233_abnormal_muscle_weight0.97302849
71MP0005410_abnormal_fertilization0.97092065
72MP0003634_abnormal_glial_cell0.95558306
73MP0005332_abnormal_amino_acid0.92093707
74MP0001346_abnormal_lacrimal_gland0.91905534
75MP0004270_analgesia0.91101950
76MP0000383_abnormal_hair_follicle0.90927786
77MP0001286_abnormal_eye_development0.89601812
78MP0002272_abnormal_nervous_system0.89486398
79MP0002697_abnormal_eye_size0.87473008
80MP0003718_maternal_effect0.83409683
81MP0010386_abnormal_urinary_bladder0.83209521
82MP0005377_hearing/vestibular/ear_phenot0.83071977
83MP0003878_abnormal_ear_physiology0.83071977
84MP0001293_anophthalmia0.82172050
85MP0000631_abnormal_neuroendocrine_gland0.81823306
86MP0009764_decreased_sensitivity_to0.81261608
87MP0003119_abnormal_digestive_system0.80754962
88MP0004019_abnormal_vitamin_homeostasis0.79803537
89MP0003186_abnormal_redox_activity0.79568845
90MP0002693_abnormal_pancreas_physiology0.78609492
91MP0003635_abnormal_synaptic_transmissio0.77990420
92MP0000647_abnormal_sebaceous_gland0.77446558
93MP0002277_abnormal_respiratory_mucosa0.77351550
94MP0000015_abnormal_ear_pigmentation0.76976410
95MP0005187_abnormal_penis_morphology0.76570911
96MP0004782_abnormal_surfactant_physiolog0.75947833
97MP0000516_abnormal_urinary_system0.75884509
98MP0005367_renal/urinary_system_phenotyp0.75884509
99MP0005360_urolithiasis0.75642206
100MP0002064_seizures0.74865862
101MP0000778_abnormal_nervous_system0.71513656
102MP0002734_abnormal_mechanical_nocicepti0.69667625
103MP0001963_abnormal_hearing_physiology0.65518103
104MP0002067_abnormal_sensory_capabilities0.64981822
105MP0004859_abnormal_synaptic_plasticity0.63471591
106MP0009046_muscle_twitch0.62561847
107MP0002184_abnormal_innervation0.62424988
108MP0002063_abnormal_learning/memory/cond0.59432860
109MP0004742_abnormal_vestibular_system0.53049742
110MP0004215_abnormal_myocardial_fiber0.49802168
111MP0009745_abnormal_behavioral_response0.48979271
112MP0002152_abnormal_brain_morphology0.48534294
113MP0002332_abnormal_exercise_endurance0.48139116
114MP0002572_abnormal_emotion/affect_behav0.46767174
115MP0005386_behavior/neurological_phenoty0.46611882
116MP0004924_abnormal_behavior0.46611882
117MP0004145_abnormal_muscle_electrophysio0.45185578
118MP0005193_abnormal_anterior_eye0.44237319
119MP0000026_abnormal_inner_ear0.43464391
120MP0003633_abnormal_nervous_system0.39920051
121MP0002092_abnormal_eye_morphology0.37909064
122MP0005595_abnormal_vascular_smooth0.37371579
123MP0003861_abnormal_nervous_system0.36809306
124MP0002066_abnormal_motor_capabilities/c0.36239607
125MP0004043_abnormal_pH_regulation0.35921439
126MP0008569_lethality_at_weaning0.35574601
127MP0000465_gastrointestinal_hemorrhage0.35486544
128MP0001968_abnormal_touch/_nociception0.35267229
129MP0003787_abnormal_imprinting0.35230801
130MP0000955_abnormal_spinal_cord0.35173587
131MP0005220_abnormal_exocrine_pancreas0.33661553
132MP0003632_abnormal_nervous_system0.32968149
133MP0002557_abnormal_social/conspecific_i0.32758748
134MP0004811_abnormal_neuron_physiology0.31703774
135MP0004085_abnormal_heartbeat0.31006435
136MP0004142_abnormal_muscle_tone0.30916227
137MP0002751_abnormal_autonomic_nervous0.30296331
138MP0000428_abnormal_craniofacial_morphol0.30227827
139MP0003631_nervous_system_phenotype0.28605343
140MP0009780_abnormal_chondrocyte_physiolo0.28237555
141MP0001879_abnormal_lymphatic_vessel0.28033001
142MP0005620_abnormal_muscle_contractility0.26360234
143MP0002928_abnormal_bile_duct0.25784808
144MP0001177_atelectasis0.25412130
145MP0005646_abnormal_pituitary_gland0.24900740
146MP0008775_abnormal_heart_ventricle0.23996090
147MP0003137_abnormal_impulse_conducting0.23102451
148MP0003045_fibrosis0.22937171
149MP0001915_intracranial_hemorrhage0.22154865
150MP0002102_abnormal_ear_morphology0.21775674
151MP0002069_abnormal_eating/drinking_beha0.20794099
152MP0003698_abnormal_male_reproductive0.20589351
153MP0004036_abnormal_muscle_relaxation0.20398832

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)9.15442448
2Pigmentary retinal degeneration (HP:0001146)8.28270769
3Scotoma (HP:0000575)7.64596647
4* Pendular nystagmus (HP:0012043)7.61567411
5* Chorioretinal atrophy (HP:0000533)7.59858087
6Abnormality of macular pigmentation (HP:0008002)7.52665750
7Severe visual impairment (HP:0001141)7.31977461
8* Abolished electroretinogram (ERG) (HP:0000550)7.28008028
9Decreased central vision (HP:0007663)6.93015432
10Attenuation of retinal blood vessels (HP:0007843)6.55435480
11Dyschromatopsia (HP:0007641)6.51500003
12Posterior subcapsular cataract (HP:0007787)6.31486828
13Macular degeneration (HP:0000608)5.49893090
14* Type II diabetes mellitus (HP:0005978)5.18040800
15Vitreoretinal degeneration (HP:0000655)5.11493830
16* Photophobia (HP:0000613)5.06511285
17Constricted visual fields (HP:0001133)4.84369339
18* Increased corneal curvature (HP:0100692)4.44711322
19* Keratoconus (HP:0000563)4.44711322
20Retinitis pigmentosa (HP:0000510)3.98451539
21Type II lissencephaly (HP:0007260)3.84277308
22Subcapsular cataract (HP:0000523)3.82422036
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.80774524
24Abnormality of alanine metabolism (HP:0010916)3.80774524
25Hyperalaninemia (HP:0003348)3.80774524
26* Cone-rod dystrophy (HP:0000548)3.41722403
27Choroideremia (HP:0001139)3.40089543
28Progressive visual loss (HP:0000529)3.38859243
29Abnormality of the renal cortex (HP:0011035)3.37091115
30Abnormality of the renal medulla (HP:0100957)3.25716195
31Chronic hepatic failure (HP:0100626)2.97032776
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.84716511
33Tubular atrophy (HP:0000092)2.78020565
34Hyperventilation (HP:0002883)2.64923871
35Inability to walk (HP:0002540)2.56123233
36Gait imbalance (HP:0002141)2.50367946
37Congenital sensorineural hearing impairment (HP:0008527)2.49199127
38Abnormal drinking behavior (HP:0030082)2.48793066
39Polydipsia (HP:0001959)2.48793066
40Congenital primary aphakia (HP:0007707)2.47893356
41Abnormal biliary tract physiology (HP:0012439)2.46604431
42Bile duct proliferation (HP:0001408)2.46604431
43Lissencephaly (HP:0001339)2.44096883
44Cerebellar dysplasia (HP:0007033)2.43415696
45True hermaphroditism (HP:0010459)2.36682317
46Renal cortical cysts (HP:0000803)2.36669848
47Pancreatic fibrosis (HP:0100732)2.31602913
48* Wide nasal bridge (HP:0000431)2.29982177
49Large for gestational age (HP:0001520)2.24202656
50Optic disc pallor (HP:0000543)2.23729720
51Nephrogenic diabetes insipidus (HP:0009806)2.23692323
52Progressive inability to walk (HP:0002505)2.23317074
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.22301845
54Absent/shortened dynein arms (HP:0200106)2.22301845
55Medial flaring of the eyebrow (HP:0010747)2.19543936
56Acute necrotizing encephalopathy (HP:0006965)2.15689890
57Retinal atrophy (HP:0001105)2.13877569
58Abnormal respiratory motile cilium morphology (HP:0005938)2.11711778
59Abnormal respiratory epithelium morphology (HP:0012253)2.11711778
60Polar cataract (HP:0010696)2.10336006
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09943891
62Polyuria (HP:0000103)2.09749093
63Birth length less than 3rd percentile (HP:0003561)2.08619254
64Retinal dysplasia (HP:0007973)2.08056228
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.07395760
66Male pseudohermaphroditism (HP:0000037)2.05255469
67Broad-based gait (HP:0002136)2.05232808
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.04260040
69Mitochondrial inheritance (HP:0001427)2.04020619
70Aplasia/Hypoplasia of the patella (HP:0006498)2.03734579
71Increased CSF lactate (HP:0002490)2.03153108
72Congenital, generalized hypertrichosis (HP:0004540)2.02486105
73Septo-optic dysplasia (HP:0100842)2.00432021
74Congenital stationary night blindness (HP:0007642)12.1548749
75Absent rod-and cone-mediated responses on ERG (HP:0007688)11.7549104
76Abnormal rod and cone electroretinograms (HP:0008323)11.0611295
77Bony spicule pigmentary retinopathy (HP:0007737)10.0817604
78Progressive macrocephaly (HP:0004481)1.96493934
79Patellar aplasia (HP:0006443)1.95968736
80Abnormality of the renal collecting system (HP:0004742)1.95537045
81Methylmalonic acidemia (HP:0002912)1.95533324
82Acute encephalopathy (HP:0006846)1.93554197
83Pancreatic cysts (HP:0001737)1.92357696
84Poor coordination (HP:0002370)1.91881561
85Gaze-evoked nystagmus (HP:0000640)1.89288561
863-Methylglutaconic aciduria (HP:0003535)1.88773968
87Severe Myopia (HP:0011003)1.86605879
88Aplasia/hypoplasia of the uterus (HP:0008684)1.86086826
89Cystic liver disease (HP:0006706)1.85345315
90Severe muscular hypotonia (HP:0006829)1.83923929
91Aplasia/Hypoplasia of the fovea (HP:0008060)1.83462619
92Hypoplasia of the fovea (HP:0007750)1.83462619
93Hypomagnesemia (HP:0002917)1.82873975
94Sclerocornea (HP:0000647)1.82600945
95Dandy-Walker malformation (HP:0001305)1.81869349
96Hypoplasia of the pons (HP:0012110)1.81564846
97Decreased circulating renin level (HP:0003351)1.81323778
98Abnormality of the pons (HP:0007361)1.80937913
99Pachygyria (HP:0001302)1.80859980
100Abnormal mitochondria in muscle tissue (HP:0008316)1.80798065
101Stomach cancer (HP:0012126)1.80643748
102Duplicated collecting system (HP:0000081)1.80029296
103Hemiparesis (HP:0001269)1.78009746
104Abnormality of the labia minora (HP:0012880)1.76235939
105Aplasia/Hypoplasia of the spleen (HP:0010451)1.76122283
106Methylmalonic aciduria (HP:0012120)1.75356296
107Abnormality of the fovea (HP:0000493)1.74484076
108Ketoacidosis (HP:0001993)1.73327088
109Vaginal atresia (HP:0000148)1.72364168
110Neoplasm of the adrenal cortex (HP:0100641)1.70634580
111Abnormal ciliary motility (HP:0012262)1.70392514
112Increased serum lactate (HP:0002151)1.70012420
113Absent speech (HP:0001344)1.69981700
114Small hand (HP:0200055)1.69757825
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.69574149
116Hepatocellular necrosis (HP:0001404)1.68725142
117Genital tract atresia (HP:0001827)1.65920832
118Aplasia/Hypoplasia of the lens (HP:0008063)1.62887727
119Epileptic encephalopathy (HP:0200134)1.58117069
120* Optic atrophy (HP:0000648)1.54743137
121Abnormality of abdominal situs (HP:0011620)1.52604475
122Abdominal situs inversus (HP:0003363)1.52604475
123Interstitial pulmonary disease (HP:0006530)1.51637874
124Aplasia/Hypoplasia of the macula (HP:0008059)1.48949925
125Febrile seizures (HP:0002373)1.47193090
126Horizontal nystagmus (HP:0000666)1.45063512
127Aplasia/Hypoplasia affecting the retina (HP:0008061)1.38290480
128Chorioretinal coloboma (HP:0000567)1.28832410
129Astigmatism (HP:0000483)1.24884999
130Anencephaly (HP:0002323)1.23050116
131Furrowed tongue (HP:0000221)1.23016168
132Dysdiadochokinesis (HP:0002075)1.20965663
133Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.17451979
134Visual hallucinations (HP:0002367)1.16006469
135Congenital hepatic fibrosis (HP:0002612)1.12701572
136Anophthalmia (HP:0000528)1.10051486
137Hypermetropia (HP:0000540)1.07123863
138Progressive cerebellar ataxia (HP:0002073)1.05721886
139Specific learning disability (HP:0001328)1.05575720
140Postaxial foot polydactyly (HP:0001830)1.02832724
141Left ventricular hypertrophy (HP:0001712)0.99796449
142Optic nerve hypoplasia (HP:0000609)0.99794501
143Absent septum pellucidum (HP:0001331)0.99118365
144Abnormality of midbrain morphology (HP:0002418)0.98863511
145Molar tooth sign on MRI (HP:0002419)0.98863511
146Aplasia/Hypoplasia affecting the fundus (HP:0008057)0.96451752
147Recurrent sinusitis (HP:0011108)0.93431432
148Broad foot (HP:0001769)0.92878669
149Postaxial hand polydactyly (HP:0001162)0.91504018
150Prolonged QT interval (HP:0001657)0.91214166
151Abnormality of the septum pellucidum (HP:0007375)0.90785977
152Retinal detachment (HP:0000541)0.90246541
153Decreased testicular size (HP:0008734)0.89437770
154Asthma (HP:0002099)0.88872907
155Genetic anticipation (HP:0003743)0.85609241
156Truncal ataxia (HP:0002078)0.85018251
157Abnormality of the parathyroid morphology (HP:0011766)0.84611602
158Abnormality of the lower motor neuron (HP:0002366)0.82769002
159Abnormality of the fingertips (HP:0001211)0.81705118
160Preaxial hand polydactyly (HP:0001177)0.81277717
161Maternal diabetes (HP:0009800)0.81018218
162Holoprosencephaly (HP:0001360)0.77890960
163Insomnia (HP:0100785)0.77871096
164Albinism (HP:0001022)0.77210485
165Nephronophthisis (HP:0000090)0.76758224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK17.69742119
2FRK5.45371233
3PBK4.49955571
4IRAK23.53802568
5ADRBK23.36293820
6MAP3K102.98504405
7ACVR1B2.95125832
8PINK12.95070177
9ZAK2.91963872
10MAP4K22.91672630
11BMPR1B2.88995811
12WNK32.39439988
13WNK42.28915429
14SGK2232.10460757
15SGK4942.10460757
16TLK12.10204605
17CAMK1G2.06016509
18TXK1.93787418
19BRD41.86467762
20PRPF4B1.74604559
21SIK21.74536743
22PAK61.73950142
23INSRR1.65378667
24ERBB21.65116332
25CAMK1D1.64311410
26OXSR11.58150135
27DAPK21.56775483
28MARK11.53603769
29AKT31.52970187
30HIPK21.49554459
31ICK1.49423857
32NEK11.47690966
33DYRK1A1.44986240
34STK391.40263212
35PNCK1.36934434
36SGK21.34444962
37CDK31.30901985
38BCKDK1.27812845
39MAPK71.27530948
40MAP3K41.18701946
41DYRK21.16327985
42ADRBK11.14071043
43STK381.13980941
44CDK121.13483939
45DYRK1B1.12783839
46TIE11.12339252
47PRKD31.11115613
48SGK31.08220913
49MAPK121.07107932
50PRKCH1.04532376
51MKNK21.03098244
52MAP2K61.02160129
53PIK3CA0.97505961
54CAMKK20.97334593
55PRKCE0.96741006
56ERBB30.96210658
57TGFBR10.95172417
58NTRK20.95107714
59MAPKAPK30.94563187
60CASK0.94031150
61CSNK1D0.90152814
62NME10.90012262
63PRKD20.87171911
64PRKAA10.86600162
65MAP2K70.86449003
66VRK10.83659086
67TRIM280.83152515
68CSNK1G10.80021579
69PRKCZ0.79547487
70EPHA40.79436914
71CSNK1G30.76780720
72CSNK1G20.76536945
73PRKCB0.76432020
74NEK60.76255924
75PTK2B0.75804642
76CDC42BPA0.75721759
77CAMK2D0.75447188
78WNK10.74877796
79SGK10.73358836
80CDK90.72515061
81PLK20.70305631
82GSK3B0.69646624
83LATS10.69295319
84PKN10.67608580
85PLK30.67498343
86MAPK150.65667276
87MAP3K70.65640694
88MAPK140.65382753
89IKBKB0.64986966
90STK38L0.64646974
91NUAK10.64609473
92PHKG20.64357116
93PHKG10.64357116
94TNIK0.64088601
95TEC0.64015859
96FGFR20.63802184
97RPS6KA30.63743720
98EIF2AK30.62726413
99MAPK90.61719602
100CAMK10.61139887
101MAPK100.60965062
102PRKCQ0.60875673
103VRK20.60428153
104BRSK20.59071994
105MUSK0.59058207
106MST40.58662849
107RPS6KA50.58487489
108CDK50.58059091
109CSNK1A1L0.58029576
110TNK20.57240119
111CDK10.57239297
112BCR0.56710799
113KSR10.56625940
114CAMKK10.53881077
115GRK50.53818376
116MKNK10.53636335
117MAPK130.53631659
118KIT0.53085408
119CAMK40.52522218
120PRKAA20.52033859
121PLK40.51789999
122CSNK1A10.50694210
123CAMK2A0.50509974
124STK160.50265822
125FGFR10.49343052
126TAOK30.49190800
127TAOK20.48988905
128MINK10.48329719
129TAF10.47351799
130YES10.47134415
131PRKACG0.46924674
132ITK0.46227430
133PRKDC0.45208898
134STK30.45203184
135IRAK10.44614320
136NEK20.44460396
137PRKCI0.44082964
138NLK0.43826055
139PAK30.43538016
140MAPKAPK50.42131938
141MAPK80.41988534
142SIK10.41452342
143STK110.41371535
144ATM0.41325081
145RIPK10.41177754
146OBSCN0.39599776
147CDK190.39533479
148RPS6KA40.39464271
149PRKG10.39311992
150EPHA30.39074478
151PRKACA0.38576435
152NTRK30.36621721
153PRKCG0.36367293
154FES0.35935789
155GRK70.35899029
156MAPK10.35768353
157WEE10.35594710
158PRKCA0.35265386
159CHEK20.34072979
160FLT30.33977787
161ATR0.31257006
162CHUK0.30946451

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.43986349
2Synaptic vesicle cycle_Homo sapiens_hsa047212.38478003
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32521540
4Butanoate metabolism_Homo sapiens_hsa006502.21567920
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.19409684
6Oxidative phosphorylation_Homo sapiens_hsa001902.10204674
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06049330
8GABAergic synapse_Homo sapiens_hsa047272.03848322
9Phototransduction_Homo sapiens_hsa0474414.5097927
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92111550
11Olfactory transduction_Homo sapiens_hsa047401.82324914
12RNA polymerase_Homo sapiens_hsa030201.81464660
13Homologous recombination_Homo sapiens_hsa034401.76023001
14Protein export_Homo sapiens_hsa030601.70161760
15Tryptophan metabolism_Homo sapiens_hsa003801.60953832
16Fanconi anemia pathway_Homo sapiens_hsa034601.59061598
17One carbon pool by folate_Homo sapiens_hsa006701.56545773
18Parkinsons disease_Homo sapiens_hsa050121.54126524
19Sulfur relay system_Homo sapiens_hsa041221.51903427
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50675269
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46754413
22Caffeine metabolism_Homo sapiens_hsa002321.46358241
23Circadian rhythm_Homo sapiens_hsa047101.46225560
24Morphine addiction_Homo sapiens_hsa050321.45047196
25Basal transcription factors_Homo sapiens_hsa030221.44808564
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41840089
27Circadian entrainment_Homo sapiens_hsa047131.39394489
28Nicotine addiction_Homo sapiens_hsa050331.33918736
29Cholinergic synapse_Homo sapiens_hsa047251.30975211
30Peroxisome_Homo sapiens_hsa041461.28067910
31Propanoate metabolism_Homo sapiens_hsa006401.24803997
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24409828
33Glutamatergic synapse_Homo sapiens_hsa047241.23957298
34Sulfur metabolism_Homo sapiens_hsa009201.21056260
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.16437235
36Regulation of autophagy_Homo sapiens_hsa041401.15283337
37RNA degradation_Homo sapiens_hsa030181.15181430
38Chemical carcinogenesis_Homo sapiens_hsa052041.13968917
39Arachidonic acid metabolism_Homo sapiens_hsa005901.09059108
40Serotonergic synapse_Homo sapiens_hsa047261.03519086
41Dopaminergic synapse_Homo sapiens_hsa047281.02571811
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02519395
43Huntingtons disease_Homo sapiens_hsa050161.00428596
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.99643423
45Insulin secretion_Homo sapiens_hsa049110.97848016
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95271749
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.93988448
48Alzheimers disease_Homo sapiens_hsa050100.86783590
49Fat digestion and absorption_Homo sapiens_hsa049750.85629690
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82872951
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81211417
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81090497
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78680112
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78624379
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78203882
56Retinol metabolism_Homo sapiens_hsa008300.77893519
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75009234
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73223578
59Asthma_Homo sapiens_hsa053100.73044770
60ABC transporters_Homo sapiens_hsa020100.72937762
61Proteasome_Homo sapiens_hsa030500.72467765
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70908498
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68648949
64beta-Alanine metabolism_Homo sapiens_hsa004100.68389831
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65570204
66Oxytocin signaling pathway_Homo sapiens_hsa049210.65547442
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64849285
68Metabolic pathways_Homo sapiens_hsa011000.64793294
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.64613811
70Vitamin digestion and absorption_Homo sapiens_hsa049770.63450497
71Pyrimidine metabolism_Homo sapiens_hsa002400.63374711
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62299732
73Renin secretion_Homo sapiens_hsa049240.61361985
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.61292476
75Type I diabetes mellitus_Homo sapiens_hsa049400.61131759
76Salivary secretion_Homo sapiens_hsa049700.60809055
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60043529
78Fructose and mannose metabolism_Homo sapiens_hsa000510.59926233
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59887803
80mTOR signaling pathway_Homo sapiens_hsa041500.59167102
81Primary immunodeficiency_Homo sapiens_hsa053400.59077472
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59062316
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58606911
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56325156
85Dilated cardiomyopathy_Homo sapiens_hsa054140.53203712
86cAMP signaling pathway_Homo sapiens_hsa040240.52606203
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52126943
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52051038
89Lysine degradation_Homo sapiens_hsa003100.51626726
90Cardiac muscle contraction_Homo sapiens_hsa042600.50507362
91Inositol phosphate metabolism_Homo sapiens_hsa005620.50022488
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49776806
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49639663
94Histidine metabolism_Homo sapiens_hsa003400.48244151
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47927412
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.47698063
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46307646
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.46153306
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44432308
100Non-homologous end-joining_Homo sapiens_hsa034500.44296267
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41270128
102Type II diabetes mellitus_Homo sapiens_hsa049300.40197394
103Graft-versus-host disease_Homo sapiens_hsa053320.40157957
104HIF-1 signaling pathway_Homo sapiens_hsa040660.40114435
105Alcoholism_Homo sapiens_hsa050340.39857139
106Fatty acid degradation_Homo sapiens_hsa000710.39331826
107Fatty acid elongation_Homo sapiens_hsa000620.38941195
108Notch signaling pathway_Homo sapiens_hsa043300.37668039
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37361409
110Cocaine addiction_Homo sapiens_hsa050300.37260694
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36823965
112mRNA surveillance pathway_Homo sapiens_hsa030150.36761287
113Gastric acid secretion_Homo sapiens_hsa049710.36759320
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36294404
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35952259
116Allograft rejection_Homo sapiens_hsa053300.35444789
117Arginine and proline metabolism_Homo sapiens_hsa003300.35014198
118Axon guidance_Homo sapiens_hsa043600.34442311
119Autoimmune thyroid disease_Homo sapiens_hsa053200.34039452
120Taste transduction_Homo sapiens_hsa047420.32715686
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32027784
122Dorso-ventral axis formation_Homo sapiens_hsa043200.31786986
123Renal cell carcinoma_Homo sapiens_hsa052110.31042136
124Calcium signaling pathway_Homo sapiens_hsa040200.30369591
125Amphetamine addiction_Homo sapiens_hsa050310.29918598
126Long-term potentiation_Homo sapiens_hsa047200.29761278
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.29465541
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28806006
129Mineral absorption_Homo sapiens_hsa049780.28291490
130Ras signaling pathway_Homo sapiens_hsa040140.28228689
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.28141242
132Purine metabolism_Homo sapiens_hsa002300.27781910
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27032480
134Chemokine signaling pathway_Homo sapiens_hsa040620.26086901
135Glucagon signaling pathway_Homo sapiens_hsa049220.25699994
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25073330
137Collecting duct acid secretion_Homo sapiens_hsa049660.24890083
138Glycerolipid metabolism_Homo sapiens_hsa005610.24197764
139MAPK signaling pathway_Homo sapiens_hsa040100.24123348
140GnRH signaling pathway_Homo sapiens_hsa049120.23659376
141Choline metabolism in cancer_Homo sapiens_hsa052310.22712505
142AMPK signaling pathway_Homo sapiens_hsa041520.20802377
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20030057
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19027402
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18289536
146Wnt signaling pathway_Homo sapiens_hsa043100.18285323
147Tight junction_Homo sapiens_hsa045300.17771317
148Endometrial cancer_Homo sapiens_hsa052130.17341321
149Bile secretion_Homo sapiens_hsa049760.16632976
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.16195001
151Pancreatic secretion_Homo sapiens_hsa049720.15991443
152Galactose metabolism_Homo sapiens_hsa000520.15477408
153Glioma_Homo sapiens_hsa052140.14544813
154ErbB signaling pathway_Homo sapiens_hsa040120.14466871
155Nitrogen metabolism_Homo sapiens_hsa009100.14411898
156Biosynthesis of amino acids_Homo sapiens_hsa012300.14366494
157Thyroid hormone synthesis_Homo sapiens_hsa049180.14158405
158Vibrio cholerae infection_Homo sapiens_hsa051100.14024579
159alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13331024
160Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.13021169
161Ether lipid metabolism_Homo sapiens_hsa005650.12901385
162Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12783434
163Ovarian steroidogenesis_Homo sapiens_hsa049130.11683507
164Hippo signaling pathway_Homo sapiens_hsa043900.11293556
165Linoleic acid metabolism_Homo sapiens_hsa005910.10422231

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