CRY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.77620482
2piRNA metabolic process (GO:0034587)5.67383428
3mitotic chromosome condensation (GO:0007076)4.99628597
4metaphase plate congression (GO:0051310)4.79627109
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.76811824
6protein localization to kinetochore (GO:0034501)4.60815795
7mitotic sister chromatid cohesion (GO:0007064)4.50051348
8DNA replication checkpoint (GO:0000076)4.47255379
9mitotic nuclear envelope disassembly (GO:0007077)4.38203640
10protein localization to chromosome, centromeric region (GO:0071459)4.28880338
11histone H2A monoubiquitination (GO:0035518)4.28686576
12regulation of sister chromatid cohesion (GO:0007063)4.24409910
13regulation of spindle organization (GO:0090224)4.21681695
14nuclear pore organization (GO:0006999)4.18950609
15establishment of chromosome localization (GO:0051303)4.15182662
16nuclear envelope disassembly (GO:0051081)4.11746937
17membrane disassembly (GO:0030397)4.11746937
18regulation of meiosis I (GO:0060631)4.07268542
19DNA replication initiation (GO:0006270)4.01744841
20attachment of spindle microtubules to kinetochore (GO:0008608)4.00672509
21nuclear pore complex assembly (GO:0051292)4.00419729
22protein K6-linked ubiquitination (GO:0085020)3.90609487
23DNA replication-dependent nucleosome assembly (GO:0006335)3.90090355
24DNA replication-dependent nucleosome organization (GO:0034723)3.90090355
25monoubiquitinated protein deubiquitination (GO:0035520)3.88875849
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88449923
27negative regulation of meiosis (GO:0045835)3.86160569
28negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.86065730
29protein localization to chromosome (GO:0034502)3.83168866
30mitotic sister chromatid segregation (GO:0000070)3.82120327
31DNA methylation involved in gamete generation (GO:0043046)3.76592127
32gene silencing by RNA (GO:0031047)3.69843063
33male meiosis (GO:0007140)3.69797892
34DNA replication-independent nucleosome assembly (GO:0006336)3.64203111
35DNA replication-independent nucleosome organization (GO:0034724)3.64203111
36folic acid-containing compound biosynthetic process (GO:0009396)3.62325128
37histone H2A ubiquitination (GO:0033522)3.61812065
38regulation of mitotic spindle organization (GO:0060236)3.59359545
39nucleobase biosynthetic process (GO:0046112)3.59076071
40meiotic cell cycle (GO:0051321)3.58690343
41ribosome assembly (GO:0042255)3.57740042
42positive regulation of chromosome segregation (GO:0051984)3.55514655
43synaptonemal complex assembly (GO:0007130)3.52639616
44purine nucleobase biosynthetic process (GO:0009113)3.51399097
45negative regulation of histone methylation (GO:0031061)3.49005654
46regulation of chromosome segregation (GO:0051983)3.47698906
47sister chromatid segregation (GO:0000819)3.44675763
48sister chromatid cohesion (GO:0007062)3.43699265
49DNA damage response, signal transduction resulting in transcription (GO:0042772)3.36655161
50DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.35201466
51nuclear envelope organization (GO:0006998)3.34310167
52regulation of histone H3-K27 methylation (GO:0061085)3.30751397
53CENP-A containing nucleosome assembly (GO:0034080)3.30231704
54chromatin remodeling at centromere (GO:0031055)3.30085588
55chromosome segregation (GO:0007059)3.29710001
56DNA unwinding involved in DNA replication (GO:0006268)3.28469845
57meiotic chromosome segregation (GO:0045132)3.27434676
58histone exchange (GO:0043486)3.26881296
59chromatin assembly or disassembly (GO:0006333)3.25180175
60meiotic nuclear division (GO:0007126)3.24137921
61maturation of 5.8S rRNA (GO:0000460)3.21778223
62synaptonemal complex organization (GO:0070193)3.20226391
63DNA strand elongation involved in DNA replication (GO:0006271)3.19585005
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.18873761
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18873761
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18873761
67regulation of RNA export from nucleus (GO:0046831)3.15630262
68regulation of meiosis (GO:0040020)3.15399112
69regulation of telomere maintenance via telomerase (GO:0032210)3.15154321
70folic acid metabolic process (GO:0046655)3.12622491
71spindle checkpoint (GO:0031577)3.11171787
72regulation of exit from mitosis (GO:0007096)3.10892531
73pyrimidine dimer repair (GO:0006290)3.10551178
74female gamete generation (GO:0007292)3.09880487
75oocyte maturation (GO:0001556)3.08641348
76meiosis I (GO:0007127)3.07424942
77negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.07417837
78negative regulation of DNA-templated transcription, elongation (GO:0032785)3.07417837
79ubiquinone metabolic process (GO:0006743)3.05928251
80DNA strand elongation (GO:0022616)3.05121119
81regulation of double-strand break repair via homologous recombination (GO:0010569)3.04692273
82histone H2A acetylation (GO:0043968)3.04123446
83regulation of centrosome cycle (GO:0046605)3.02904931
84COPI coating of Golgi vesicle (GO:0048205)3.01943601
85Golgi transport vesicle coating (GO:0048200)3.01943601
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00682349
87fatty acid elongation (GO:0030497)2.97729773
88kinetochore organization (GO:0051383)2.97709030
89negative regulation of chromosome segregation (GO:0051985)2.96990890
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96963100
91male meiosis I (GO:0007141)2.96962642
92kinetochore assembly (GO:0051382)2.96790030
93meiotic cell cycle process (GO:1903046)2.96576424
94snRNA transcription (GO:0009301)2.95812003
95DNA alkylation (GO:0006305)2.93319935
96DNA methylation (GO:0006306)2.93319935
97mitotic spindle checkpoint (GO:0071174)2.92724890
98inner cell mass cell proliferation (GO:0001833)2.92511201
99ribosome biogenesis (GO:0042254)2.92285780
100pre-miRNA processing (GO:0031054)2.89540423
101COPII vesicle coating (GO:0048208)2.88382126
102gene silencing (GO:0016458)2.87639618
103resolution of meiotic recombination intermediates (GO:0000712)2.87394103
104negative regulation of mitotic sister chromatid separation (GO:2000816)2.87288375
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87288375
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87288375
107negative regulation of sister chromatid segregation (GO:0033046)2.87288375
108paraxial mesoderm development (GO:0048339)2.85505420
109regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.83124118
110negative regulation of mRNA processing (GO:0050686)2.77231391
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74714097
112pore complex assembly (GO:0046931)2.70018575
113single strand break repair (GO:0000012)2.69452740
114negative regulation of DNA recombination (GO:0045910)2.67264354
115RNA localization (GO:0006403)2.61668188
116olfactory bulb development (GO:0021772)2.60329854
117isoprenoid biosynthetic process (GO:0008299)2.60255013
118astrocyte differentiation (GO:0048708)2.59963156
119photoreceptor cell differentiation (GO:0046530)2.58902854
120eye photoreceptor cell differentiation (GO:0001754)2.58902854
121intraciliary transport (GO:0042073)2.56951363
122protein localization to cilium (GO:0061512)2.55876382
123cellular protein complex localization (GO:0034629)2.50648108
124synapsis (GO:0007129)2.48987313
125regulation of DNA methylation (GO:0044030)2.47557747
126protein K11-linked ubiquitination (GO:0070979)2.47493202
127proteasome assembly (GO:0043248)2.46919147
128stress granule assembly (GO:0034063)2.46553580
129UDP-N-acetylglucosamine metabolic process (GO:0006047)2.40965190
130ubiquinone biosynthetic process (GO:0006744)2.39589219
131cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.38980550
132spliceosomal tri-snRNP complex assembly (GO:0000244)2.38683898
133negative regulation of meiotic cell cycle (GO:0051447)2.38472176
134DNA ligation (GO:0006266)2.36940452
135transcription elongation from RNA polymerase I promoter (GO:0006362)2.36939149
136regulation of mitotic metaphase/anaphase transition (GO:0030071)2.33233436
137endoplasmic reticulum organization (GO:0007029)2.32545419
138cholesterol biosynthetic process (GO:0006695)2.32341538
139dorsal/ventral axis specification (GO:0009950)2.31009075
140negative regulation of mRNA metabolic process (GO:1903312)2.30968879
141centriole replication (GO:0007099)2.30890872
142regulation of mitotic sister chromatid separation (GO:0010965)2.28906021
143regulation of mitotic sister chromatid segregation (GO:0033047)2.28906021
144regulation of sister chromatid segregation (GO:0033045)2.28906021
145negative regulation of NF-kappaB import into nucleus (GO:0042347)2.28430172
146positive regulation of mRNA 3-end processing (GO:0031442)2.28209240
147positive regulation of mitochondrial fission (GO:0090141)2.28166684
148mitotic spindle assembly checkpoint (GO:0007094)2.27300894
149regulation of centriole replication (GO:0046599)2.26985168
150response to follicle-stimulating hormone (GO:0032354)2.26496005
151negative regulation of neurotransmitter transport (GO:0051589)2.23926597
152positive regulation of translational initiation (GO:0045948)2.23822459
153spindle assembly checkpoint (GO:0071173)2.22968834
154cullin deneddylation (GO:0010388)2.22925062
155dosage compensation (GO:0007549)2.22408281
156morphogenesis of an epithelial sheet (GO:0002011)2.22179361
157ER overload response (GO:0006983)2.21212607
158regulation of mRNA splicing, via spliceosome (GO:0048024)2.20854910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.40551478
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.34010682
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.84222547
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.69738166
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69519436
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.52561779
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.35409064
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29364185
9AR_21909140_ChIP-Seq_LNCAP_Human2.95338879
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45756421
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.44636672
12MYC_22102868_ChIP-Seq_BL_Human2.44424448
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.40033456
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37869919
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.27515912
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.25770247
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25756343
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24467909
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23188410
20* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.22186361
21ELK1_19687146_ChIP-ChIP_HELA_Human2.18298553
22TAF15_26573619_Chip-Seq_HEK293_Human2.11847577
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07523804
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05484334
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04140303
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02615610
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97435318
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88309260
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87801698
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.87006279
31XRN2_22483619_ChIP-Seq_HELA_Human1.84714957
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84511605
33* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80984894
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.79758205
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77549198
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.75292602
37GABP_19822575_ChIP-Seq_HepG2_Human1.71861085
38* VDR_23849224_ChIP-Seq_CD4+_Human1.71453948
39KDM5A_27292631_Chip-Seq_BREAST_Human1.69048986
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.68235919
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.64143967
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61091366
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60898469
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59988825
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59969660
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59969660
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59969660
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58600889
49FUS_26573619_Chip-Seq_HEK293_Human1.56810680
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56785710
51EWS_26573619_Chip-Seq_HEK293_Human1.56503111
52* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55518971
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53871618
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53200678
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52582636
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51460759
57CIITA_25753668_ChIP-Seq_RAJI_Human1.47633669
58GBX2_23144817_ChIP-Seq_PC3_Human1.45614930
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45130028
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44206156
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43153275
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41546748
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40973400
64FOXP3_21729870_ChIP-Seq_TREG_Human1.40130848
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38579466
66DCP1A_22483619_ChIP-Seq_HELA_Human1.37608339
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37065515
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36851127
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.34463733
70IGF1R_20145208_ChIP-Seq_DFB_Human1.34158190
71ZNF274_21170338_ChIP-Seq_K562_Hela1.33306909
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32229378
73TTF2_22483619_ChIP-Seq_HELA_Human1.31882418
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31722468
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31547234
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28931254
77IRF1_19129219_ChIP-ChIP_H3396_Human1.25047054
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24688870
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.24648767
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24016852
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18055137
82* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17216066
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16295413
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16104422
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15906996
86KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14789426
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13766650
88* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13563727
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13470140
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10625618
91* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10350312
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09873214
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09745528
94TFEB_21752829_ChIP-Seq_HELA_Human1.09513114
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07055546
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06898721
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06817615
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06015233
99REST_19997604_ChIP-ChIP_NEURONS_Mouse1.05311003
100P300_19829295_ChIP-Seq_ESCs_Human1.04976150
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04763388
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04693095
103MYC_18940864_ChIP-ChIP_HL60_Human1.04181675
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03537722
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03532366
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03425677
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01655549
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01215677
109* SMAD4_21799915_ChIP-Seq_A2780_Human1.00453653
110* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99923465
111CLOCK_20551151_ChIP-Seq_293T_Human0.99828510
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99748669
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99289291
114* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97701915
115* CBP_20019798_ChIP-Seq_JUKART_Human0.97701915
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96978610
117SOX9_26525672_Chip-Seq_HEART_Mouse0.96534853
118ATF3_27146783_Chip-Seq_COLON_Human0.95181883
119EZH2_22144423_ChIP-Seq_EOC_Human0.95009391
120HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92904433
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92088320
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91451764
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.90635287
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90100140
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89709099
126CHD1_26751641_Chip-Seq_LNCaP_Human0.89117667
127UTX_26944678_Chip-Seq_JUKART_Human0.88970986
128* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88698670
129THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87098674
130VDR_21846776_ChIP-Seq_THP-1_Human0.86302943
131KAP1_27257070_Chip-Seq_ESCs_Mouse0.84882369
132ZNF263_19887448_ChIP-Seq_K562_Human0.83798657
133PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82461511
134NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82260282
135YY1_21170310_ChIP-Seq_MESCs_Mouse0.81913487
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81590627
137TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80866423
138TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80824281
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80648092
140MYB_26560356_Chip-Seq_TH2_Human0.80254108
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78846260
142TCF7_22412390_ChIP-Seq_EML_Mouse0.78549619
143MYB_26560356_Chip-Seq_TH1_Human0.77679910
144* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77533497
145TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77202034
146POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76194032
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73641548
148* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72296957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.02900502
2MP0010094_abnormal_chromosome_stability4.11413903
3MP0003111_abnormal_nucleus_morphology4.02109514
4MP0008877_abnormal_DNA_methylation3.61369327
5MP0004957_abnormal_blastocyst_morpholog3.60295791
6MP0003077_abnormal_cell_cycle3.59454563
7MP0002653_abnormal_ependyma_morphology3.41758192
8MP0008057_abnormal_DNA_replication3.33041740
9MP0003718_maternal_effect3.03005560
10MP0008007_abnormal_cellular_replicative2.91052197
11MP0005394_taste/olfaction_phenotype2.65575005
12MP0005499_abnormal_olfactory_system2.65575005
13MP0003123_paternal_imprinting2.65308461
14MP0002822_catalepsy2.59808634
15MP0008058_abnormal_DNA_repair2.57529145
16MP0003646_muscle_fatigue2.53615124
17MP0000350_abnormal_cell_proliferation2.42456378
18MP0001730_embryonic_growth_arrest2.36006384
19MP0008789_abnormal_olfactory_epithelium2.18873118
20MP0010352_gastrointestinal_tract_polyps2.03305498
21MP0002210_abnormal_sex_determination2.02085749
22MP0008932_abnormal_embryonic_tissue2.00512181
23MP0001929_abnormal_gametogenesis1.96655217
24MP0005451_abnormal_body_composition1.89053414
25MP0005076_abnormal_cell_differentiation1.82892987
26MP0010307_abnormal_tumor_latency1.81576790
27MP0001697_abnormal_embryo_size1.81401006
28MP0001672_abnormal_embryogenesis/_devel1.80246098
29MP0005380_embryogenesis_phenotype1.80246098
30MP0002085_abnormal_embryonic_tissue1.74095937
31MP0000653_abnormal_sex_gland1.70256020
32MP0002084_abnormal_developmental_patter1.69878903
33MP0002234_abnormal_pharynx_morphology1.69490266
34MP0003786_premature_aging1.68400322
35MP0002102_abnormal_ear_morphology1.65901063
36MP0003121_genomic_imprinting1.63888228
37MP0003656_abnormal_erythrocyte_physiolo1.62445551
38MP0001145_abnormal_male_reproductive1.61990327
39MP0003984_embryonic_growth_retardation1.57940471
40MP0003763_abnormal_thymus_physiology1.57181825
41MP0001984_abnormal_olfaction1.56256154
42MP0001119_abnormal_female_reproductive1.56000574
43MP0000537_abnormal_urethra_morphology1.55015761
44MP0002088_abnormal_embryonic_growth/wei1.54047753
45MP0000778_abnormal_nervous_system1.53680291
46MP0001727_abnormal_embryo_implantation1.50298981
47MP0009046_muscle_twitch1.48932366
48MP0002080_prenatal_lethality1.43533339
49MP0000490_abnormal_crypts_of1.42122976
50MP0003699_abnormal_female_reproductive1.41714446
51MP0002233_abnormal_nose_morphology1.40971239
52MP0001529_abnormal_vocalization1.40049342
53MP0009333_abnormal_splenocyte_physiolog1.39511763
54MP0006292_abnormal_olfactory_placode1.37052055
55MP0002019_abnormal_tumor_incidence1.36547509
56MP0002396_abnormal_hematopoietic_system1.36515567
57MP0002086_abnormal_extraembryonic_tissu1.31587606
58MP0000647_abnormal_sebaceous_gland1.29199955
59MP0005187_abnormal_penis_morphology1.24463444
60MP0003221_abnormal_cardiomyocyte_apopto1.23546437
61MP0003890_abnormal_embryonic-extraembry1.23047048
62MP0004197_abnormal_fetal_growth/weight/1.20648984
63MP0000013_abnormal_adipose_tissue1.17558683
64MP0003937_abnormal_limbs/digits/tail_de1.17019821
65MP0001188_hyperpigmentation1.16531173
66MP0004811_abnormal_neuron_physiology1.15823507
67MP0002090_abnormal_vision1.15252534
68MP0005391_vision/eye_phenotype1.15244016
69MP0002697_abnormal_eye_size1.14091368
70MP0004185_abnormal_adipocyte_glucose1.13826999
71* MP0001502_abnormal_circadian_rhythm1.13784484
72MP0005253_abnormal_eye_physiology1.13618433
73MP0005395_other_phenotype1.12629366
74MP0003122_maternal_imprinting1.12031249
75MP0010030_abnormal_orbit_morphology1.11605215
76MP0003787_abnormal_imprinting1.10472970
77MP0002161_abnormal_fertility/fecundity1.09787348
78* MP0006276_abnormal_autonomic_nervous1.09558712
79MP0000313_abnormal_cell_death1.08577664
80MP0005410_abnormal_fertilization1.07524447
81MP0009672_abnormal_birth_weight1.07252398
82MP0002909_abnormal_adrenal_gland1.02199020
83MP0003698_abnormal_male_reproductive1.02024271
84MP0000703_abnormal_thymus_morphology1.01041303
85MP0005248_abnormal_Harderian_gland1.00615417
86MP0004233_abnormal_muscle_weight0.98741958
87MP0003880_abnormal_central_pattern0.98589312
88MP0005621_abnormal_cell_physiology0.95750708
89MP0009840_abnormal_foam_cell0.95198580
90MP0004264_abnormal_extraembryonic_tissu0.91862412
91MP0003705_abnormal_hypodermis_morpholog0.90925584
92MP0002736_abnormal_nociception_after0.90133192
93MP0000049_abnormal_middle_ear0.89698635
94MP0001501_abnormal_sleep_pattern0.89554171
95MP0000955_abnormal_spinal_cord0.88207665
96MP0008260_abnormal_autophagy0.88008134
97MP0005384_cellular_phenotype0.85348733
98MP0002398_abnormal_bone_marrow0.84900021
99MP0002184_abnormal_innervation0.84528926
100MP0000631_abnormal_neuroendocrine_gland0.84354457
101MP0003195_calcinosis0.82979295
102MP0002009_preneoplasia0.82977520
103MP0004808_abnormal_hematopoietic_stem0.82686655
104MP0001915_intracranial_hemorrhage0.81713979
105MP0002877_abnormal_melanocyte_morpholog0.80926075
106MP0000689_abnormal_spleen_morphology0.80239334
107MP0005220_abnormal_exocrine_pancreas0.79954516
108MP0002249_abnormal_larynx_morphology0.78361170
109MP0003115_abnormal_respiratory_system0.78190636
110MP0003119_abnormal_digestive_system0.75954226
111MP0002722_abnormal_immune_system0.75651511
112MP0004859_abnormal_synaptic_plasticity0.74728936
113MP0008995_early_reproductive_senescence0.73822515
114MP0004133_heterotaxia0.72779876
115MP0001270_distended_abdomen0.71840225
116MP0000428_abnormal_craniofacial_morphol0.71172348
117MP0002081_perinatal_lethality0.70788331
118MP0002557_abnormal_social/conspecific_i0.70108786
119MP0001849_ear_inflammation0.65538636
120MP0003861_abnormal_nervous_system0.65372169
121MP0009703_decreased_birth_body0.65237425
122MP0006072_abnormal_retinal_apoptosis0.64775827
123MP0003567_abnormal_fetal_cardiomyocyte0.64350670
124MP0001293_anophthalmia0.63232686
125MP0003755_abnormal_palate_morphology0.63229384
126MP0005408_hypopigmentation0.63190080
127MP0000432_abnormal_head_morphology0.61558460
128MP0000733_abnormal_muscle_development0.61391333
129MP0000358_abnormal_cell_content/0.60915808
130MP0003315_abnormal_perineum_morphology0.60631355
131MP0005397_hematopoietic_system_phenotyp0.58171790
132MP0001545_abnormal_hematopoietic_system0.58171790
133MP0003935_abnormal_craniofacial_develop0.58005273
134MP0002160_abnormal_reproductive_system0.57864333
135MP0005023_abnormal_wound_healing0.57302593
136MP0010234_abnormal_vibrissa_follicle0.55313298
137MP0002282_abnormal_trachea_morphology0.53957910
138MP0002405_respiratory_system_inflammati0.53938553
139MP0002429_abnormal_blood_cell0.53912135
140MP0001851_eye_inflammation0.51177839
141MP0000858_altered_metastatic_potential0.50726085
142MP0002092_abnormal_eye_morphology0.50627467
143MP0001286_abnormal_eye_development0.50181603

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.05650962
2Cortical dysplasia (HP:0002539)4.19161158
3Facial hemangioma (HP:0000329)4.04419837
4Breast hypoplasia (HP:0003187)4.02649289
5Patellar aplasia (HP:0006443)3.93207633
6Abnormality of the labia minora (HP:0012880)3.67361286
7Carpal bone hypoplasia (HP:0001498)3.60066078
8Aplasia/Hypoplasia of the patella (HP:0006498)3.59520854
9Male infertility (HP:0003251)3.45541300
10Oral leukoplakia (HP:0002745)3.43409053
11Overlapping toe (HP:0001845)3.05983894
12Chromsome breakage (HP:0040012)2.93997818
13Irregular epiphyses (HP:0010582)2.89085314
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.88154661
15Impulsivity (HP:0100710)2.85006667
16Rimmed vacuoles (HP:0003805)2.83900060
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79551502
18Oligodactyly (HP:0012165)2.75487484
19Flat capital femoral epiphysis (HP:0003370)2.73463489
20Premature ovarian failure (HP:0008209)2.69869290
21Gonadotropin excess (HP:0000837)2.69414987
22Secondary amenorrhea (HP:0000869)2.69398511
23Abnormality of the anterior horn cell (HP:0006802)2.68606562
24Degeneration of anterior horn cells (HP:0002398)2.68606562
25Abnormality of the fingertips (HP:0001211)2.68040641
26Capillary hemangiomas (HP:0005306)2.67157149
27Aplasia/Hypoplasia of the sternum (HP:0006714)2.66673813
28Oligodactyly (hands) (HP:0001180)2.64443465
29Medulloblastoma (HP:0002885)2.63218380
30Abnormality of the hip-girdle musculature (HP:0001445)2.61750901
31Abnormality of the musculature of the pelvis (HP:0001469)2.61750901
32Abnormality of chromosome stability (HP:0003220)2.61513013
33Papillary thyroid carcinoma (HP:0002895)2.59912184
34Prominent nose (HP:0000448)2.57823452
35Abnormality of the metopic suture (HP:0005556)2.55800362
36Small epiphyses (HP:0010585)2.55781468
37Shawl scrotum (HP:0000049)2.50820427
38Spastic diplegia (HP:0001264)2.46855792
39Neoplasm of the oral cavity (HP:0100649)2.42961757
40Meckel diverticulum (HP:0002245)2.42618164
41Prominent metopic ridge (HP:0005487)2.39736668
42Abnormality of chromosome segregation (HP:0002916)2.39304975
43Supernumerary spleens (HP:0009799)2.38538218
44Rough bone trabeculation (HP:0100670)2.35608822
45Ependymoma (HP:0002888)2.34500139
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.31054507
47Congenital primary aphakia (HP:0007707)2.27704428
48Postnatal microcephaly (HP:0005484)2.27649751
49Thyroid carcinoma (HP:0002890)2.26297125
50Abnormality of the ileum (HP:0001549)2.24412452
51Adrenal hypoplasia (HP:0000835)2.23559616
52Unilateral renal agenesis (HP:0000122)2.23163741
53Deviation of the thumb (HP:0009603)2.22715644
54Upper limb muscle weakness (HP:0003484)2.21644870
55Nephrogenic diabetes insipidus (HP:0009806)2.19447206
56Abnormality of the lower motor neuron (HP:0002366)2.17951826
57Gait imbalance (HP:0002141)2.17430220
58Selective tooth agenesis (HP:0001592)2.17092391
59Pelvic girdle muscle weakness (HP:0003749)2.15942669
60Hypoglycemic seizures (HP:0002173)2.14602001
61Absent radius (HP:0003974)2.14305197
62Cafe-au-lait spot (HP:0000957)2.13459981
63Breast aplasia (HP:0100783)2.12577577
64Abnormality of lateral ventricle (HP:0030047)2.11868376
65Tubulointerstitial nephritis (HP:0001970)2.10370723
66Abnormal gallbladder physiology (HP:0012438)2.10306879
67Cholecystitis (HP:0001082)2.10306879
68Abnormality of the preputium (HP:0100587)2.08291130
69Acute myeloid leukemia (HP:0004808)2.07013226
70Broad palm (HP:0001169)2.06083812
71Myelodysplasia (HP:0002863)2.05627445
72Slender long bone (HP:0003100)2.05380251
73Hypsarrhythmia (HP:0002521)2.05115250
74Aplasia involving forearm bones (HP:0009822)2.04901069
75Absent forearm bone (HP:0003953)2.04901069
76Sandal gap (HP:0001852)2.04030798
77Large for gestational age (HP:0001520)2.03411279
78Hypoglycemic coma (HP:0001325)2.01479526
79Proximal placement of thumb (HP:0009623)2.01468846
80Sloping forehead (HP:0000340)2.01171229
81Volvulus (HP:0002580)2.01017698
82Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99707733
83Atresia of the external auditory canal (HP:0000413)1.99121007
84Rhabdomyosarcoma (HP:0002859)1.97614682
85Posterior subcapsular cataract (HP:0007787)1.96530923
86Bone marrow hypocellularity (HP:0005528)1.96218467
87Bifid tongue (HP:0010297)1.96068382
88Increased nuchal translucency (HP:0010880)1.94962562
89Aplasia/Hypoplasia of the breasts (HP:0010311)1.94803457
90Medial flaring of the eyebrow (HP:0010747)1.94773936
91Abnormal hair whorl (HP:0010721)1.94360826
92Pendular nystagmus (HP:0012043)1.94227152
93Short tibia (HP:0005736)1.92635620
94Drooling (HP:0002307)1.92599352
95EEG with generalized epileptiform discharges (HP:0011198)1.92345742
96Colon cancer (HP:0003003)1.92239729
97Diastasis recti (HP:0001540)1.90248493
98Abnormal spermatogenesis (HP:0008669)1.89347702
99Aplastic anemia (HP:0001915)1.89239104
100Lissencephaly (HP:0001339)1.88942861
101Nephroblastoma (Wilms tumor) (HP:0002667)1.87450710
102Embryonal renal neoplasm (HP:0011794)1.86909807
103Thin upper lip vermilion (HP:0000219)1.86483330
104Ectopic kidney (HP:0000086)1.86117269
105Small intestinal stenosis (HP:0012848)1.85464668
106Duodenal stenosis (HP:0100867)1.85464668
107Oculomotor apraxia (HP:0000657)1.85212222
108Short thumb (HP:0009778)1.84174245
109Absent epiphyses (HP:0010577)1.83954143
110Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83954143
111Labial hypoplasia (HP:0000066)1.83765614
112Neoplasm of the pancreas (HP:0002894)1.83659636
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83536018
114High pitched voice (HP:0001620)1.83165935
115Atrophy/Degeneration involving motor neurons (HP:0007373)1.82927947
116Limb-girdle muscle atrophy (HP:0003797)1.82815080
117Genital tract atresia (HP:0001827)1.82246317
118Pulmonary fibrosis (HP:0002206)1.81847146
119Large eyes (HP:0001090)1.81479809
120Retinal dysplasia (HP:0007973)1.81189539
121Rib fusion (HP:0000902)1.79016844
122Abnormality of the epiphysis of the femoral head (HP:0010574)1.78844392
123Epileptiform EEG discharges (HP:0011182)1.78646793
124Optic nerve hypoplasia (HP:0000609)1.78097333
125Neoplasm of striated muscle (HP:0009728)1.78037229
126Pancreatic fibrosis (HP:0100732)1.76535445
127Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.76249571
128Abnormality of femoral epiphyses (HP:0006499)1.76249571
129Hammertoe (HP:0001765)1.76166711
130Metaphyseal cupping (HP:0003021)1.75972013
131Delayed puberty (HP:0000823)1.75755627
132Vertebral arch anomaly (HP:0008438)1.75742155
133Cellular immunodeficiency (HP:0005374)1.74948308
134Entropion (HP:0000621)1.74901036
135Hypoplastic female external genitalia (HP:0012815)1.73905692
136Shoulder girdle muscle weakness (HP:0003547)1.73704744
137Intestinal atresia (HP:0011100)1.73266865
138Microretrognathia (HP:0000308)1.72771614
139Urethral obstruction (HP:0000796)1.72140524
140Limb-girdle muscle weakness (HP:0003325)1.71910485
141Limb dystonia (HP:0002451)1.70446138
142Abnormality of the proximal phalanges of the hand (HP:0009834)1.70077421
143Abnormality of the carotid arteries (HP:0005344)1.69992905
144Hand muscle atrophy (HP:0009130)1.69431689
145Truncal obesity (HP:0001956)1.68904212
146Micropenis (HP:0000054)1.67945197
147Tetraplegia (HP:0002445)1.67784877
148Broad alveolar ridges (HP:0000187)1.67768062
149Abnormality of the duodenum (HP:0002246)1.67469026
150Vaginal atresia (HP:0000148)1.67040952
151Absent speech (HP:0001344)1.65688933
152Short 4th metacarpal (HP:0010044)1.65481501
153Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65481501
154Broad foot (HP:0001769)1.64949043
155Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64840046
156Long eyelashes (HP:0000527)1.63974968
157Abnormality of the femoral head (HP:0003368)1.63221959
158Septo-optic dysplasia (HP:0100842)1.62548001
159Excessive salivation (HP:0003781)1.61919199
160Esotropia (HP:0000565)1.61766277
161Cone-rod dystrophy (HP:0000548)1.60866400
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.60474113
163Abnormal lung lobation (HP:0002101)1.59850311
164Failure to thrive in infancy (HP:0001531)1.59335439
165Decreased testicular size (HP:0008734)1.57708493
166Broad nasal tip (HP:0000455)1.56925395
167Specific learning disability (HP:0001328)1.55606245
168Poor coordination (HP:0002370)1.55536326
169Aplasia/Hypoplasia of the brainstem (HP:0007362)1.53464055
170Hypoplasia of the brainstem (HP:0002365)1.53464055
171Limb hypertonia (HP:0002509)1.52615567
172Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.50542387
173Postaxial hand polydactyly (HP:0001162)1.50246864
174Symptomatic seizures (HP:0011145)1.49720003
175Septate vagina (HP:0001153)1.48704188
176Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.48591071
177Abnormality of the labia (HP:0000058)1.48293718
178Aganglionic megacolon (HP:0002251)1.46539064
179Abnormality of the anterior chamber (HP:0000593)1.46250159
180Atonic seizures (HP:0010819)1.46039428
181Prominent nasal bridge (HP:0000426)1.45284552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.87925780
2MAP4K23.55878996
3NEK23.28088292
4LATS13.01943630
5MAP3K42.98135228
6PLK42.97735228
7WEE12.87577640
8EEF2K2.87195259
9LATS22.77383229
10ACVR1B2.76011885
11STK38L2.72542067
12MAP2K72.62625095
13ERBB32.55119775
14CSNK1G32.53288893
15BCR2.48483892
16MAP3K62.42248669
17TTK2.40402628
18CSNK1G22.21245411
19BUB12.14193013
20TRIM281.98664509
21EPHA31.96869663
22DYRK31.94724614
23MST41.92606864
24STK31.91462432
25CDK121.86908043
26TAOK11.84519725
27KSR21.73802426
28PLK11.73529747
29ERBB41.71856208
30CHEK21.68186874
31NEK11.54778864
32RPS6KA41.49687120
33RPS6KB21.48222584
34CSNK1A1L1.47501379
35BRSK21.44907191
36SRPK11.43089386
37BRAF1.41570024
38EIF2AK11.39374344
39CDK41.34312616
40CDK81.33878678
41RAF11.33145421
42STK101.32576240
43MAPKAPK31.32400166
44TRIB31.31001255
45MELK1.30557793
46NUAK11.29000786
47CASK1.27579945
48NTRK21.24341746
49CDK71.23478362
50ATR1.20769375
51AURKB1.20728633
52ZAK1.20222313
53PRKD31.18143673
54CHEK11.17419206
55EIF2AK31.15663313
56CDK91.12300339
57PLK31.09557874
58MAP3K81.07963233
59TSSK61.04896757
60TESK21.04070899
61BRSK11.02631612
62PKN21.01765041
63TAOK31.01198598
64KSR11.01177491
65MAP3K90.98900545
66PDK20.96541430
67MOS0.96237285
68WNK30.95075238
69NLK0.94349906
70MKNK20.89613388
71MET0.84861638
72PLK20.84428730
73ARAF0.82695828
74CDK20.82132769
75DYRK20.81883086
76AURKA0.80239404
77ATM0.78517401
78PIM10.75110416
79MARK10.75073865
80SIK30.74377083
81TYRO30.74056806
82MAP4K10.73394311
83AKT30.71814518
84STK380.69257830
85MAP3K100.69253651
86ABL20.68209413
87JAK30.67124280
88NEK60.65731836
89MAP3K50.65569573
90PASK0.64084463
91EPHB10.63981921
92TGFBR10.63849228
93RPS6KA50.63399187
94PBK0.62995375
95MTOR0.61858820
96CSNK1E0.60960959
97CDK10.59114490
98STK240.58912267
99PDK30.58278671
100PDK40.58278671
101SCYL20.57894966
102PAK60.57066403
103IRAK20.54027502
104CDK30.53485256
105MUSK0.52091687
106YES10.51632261
107ALK0.50687320
108MAP3K140.50443629
109MAPK130.49521389
110PINK10.49011904
111MAPK110.48104044
112CDK140.46594220
113MAP3K130.46459518
114CSNK1D0.46390107
115MAP3K120.46368250
116MKNK10.45706534
117TNIK0.44464009
118BRD40.44370246
119NTRK30.43668350
120CDK60.43554525
121ZAP700.43449790
122DYRK1A0.42566634
123MAP3K30.42276941
124TESK10.41085433
125UHMK10.40424523
126SGK20.39999514
127PRKD20.39988135
128AKT20.39800827
129CDK180.38369038
130RPS6KB10.38143499
131IRAK10.37825094
132PAK10.37750513
133VRK10.37633744
134EPHA20.37588846
135MAP2K30.36800478
136DMPK0.34332584
137CHUK0.34107639
138BMPR20.32469327
139RIPK10.32044939
140CSNK1G10.31129677
141* PRKAA10.31049830
142STK40.29205707
143CCNB10.27611617
144MAPK140.26433002
145FLT30.25601859
146MAPK100.25498385

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.64739893
2DNA replication_Homo sapiens_hsa030303.61364173
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53351025
4RNA transport_Homo sapiens_hsa030133.17164041
5Mismatch repair_Homo sapiens_hsa034302.70292132
6RNA polymerase_Homo sapiens_hsa030202.60661413
7Base excision repair_Homo sapiens_hsa034102.58735436
8Basal transcription factors_Homo sapiens_hsa030222.58065599
9RNA degradation_Homo sapiens_hsa030182.54507052
10Homologous recombination_Homo sapiens_hsa034402.52833293
11Spliceosome_Homo sapiens_hsa030402.41127659
12Vitamin B6 metabolism_Homo sapiens_hsa007502.38490980
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.33801754
14Nucleotide excision repair_Homo sapiens_hsa034202.25089335
15Fanconi anemia pathway_Homo sapiens_hsa034602.24027014
16One carbon pool by folate_Homo sapiens_hsa006702.17101710
17Steroid biosynthesis_Homo sapiens_hsa001002.08552027
18mRNA surveillance pathway_Homo sapiens_hsa030152.00465040
19p53 signaling pathway_Homo sapiens_hsa041151.98858368
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90314403
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89179118
22Protein export_Homo sapiens_hsa030601.77885465
23Pyrimidine metabolism_Homo sapiens_hsa002401.74195604
24Fatty acid elongation_Homo sapiens_hsa000621.73367688
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.73253471
26* Circadian rhythm_Homo sapiens_hsa047101.65318301
27Oocyte meiosis_Homo sapiens_hsa041141.64275725
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57205544
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52078950
30Pentose phosphate pathway_Homo sapiens_hsa000301.43881079
31Non-homologous end-joining_Homo sapiens_hsa034501.37445171
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36664929
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35569336
34Biosynthesis of amino acids_Homo sapiens_hsa012301.29400255
35mTOR signaling pathway_Homo sapiens_hsa041501.25834315
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25755093
37Epstein-Barr virus infection_Homo sapiens_hsa051691.22535761
38Colorectal cancer_Homo sapiens_hsa052101.20020661
39TGF-beta signaling pathway_Homo sapiens_hsa043501.19423102
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.17960458
41MicroRNAs in cancer_Homo sapiens_hsa052061.17090988
42Pancreatic cancer_Homo sapiens_hsa052121.15729441
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15147518
44Herpes simplex infection_Homo sapiens_hsa051681.10465191
45Folate biosynthesis_Homo sapiens_hsa007901.10166525
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08650755
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08474600
48Synaptic vesicle cycle_Homo sapiens_hsa047211.06282450
49Vibrio cholerae infection_Homo sapiens_hsa051101.02523883
50Purine metabolism_Homo sapiens_hsa002301.00647296
51Viral carcinogenesis_Homo sapiens_hsa052030.98642817
52HTLV-I infection_Homo sapiens_hsa051660.94207134
53Thyroid cancer_Homo sapiens_hsa052160.93939540
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92702825
55Pyruvate metabolism_Homo sapiens_hsa006200.85270026
56Regulation of autophagy_Homo sapiens_hsa041400.84480918
57Cocaine addiction_Homo sapiens_hsa050300.83336745
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81528565
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80888007
60Type II diabetes mellitus_Homo sapiens_hsa049300.80880014
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80605227
62Sulfur metabolism_Homo sapiens_hsa009200.80538412
63Antigen processing and presentation_Homo sapiens_hsa046120.79992668
64Nicotine addiction_Homo sapiens_hsa050330.79991386
65Sphingolipid metabolism_Homo sapiens_hsa006000.79625229
66Hippo signaling pathway_Homo sapiens_hsa043900.77787338
67Chronic myeloid leukemia_Homo sapiens_hsa052200.77602206
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76921868
69Small cell lung cancer_Homo sapiens_hsa052220.75493363
70Proteasome_Homo sapiens_hsa030500.75362200
71Dorso-ventral axis formation_Homo sapiens_hsa043200.74870374
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74621129
73Propanoate metabolism_Homo sapiens_hsa006400.73943420
74Renal cell carcinoma_Homo sapiens_hsa052110.73818401
75Selenocompound metabolism_Homo sapiens_hsa004500.73616164
76Alcoholism_Homo sapiens_hsa050340.72423646
77FoxO signaling pathway_Homo sapiens_hsa040680.72226063
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71860594
79Butanoate metabolism_Homo sapiens_hsa006500.70688832
80Notch signaling pathway_Homo sapiens_hsa043300.70019696
81Amphetamine addiction_Homo sapiens_hsa050310.69231626
82T cell receptor signaling pathway_Homo sapiens_hsa046600.68665231
83Dopaminergic synapse_Homo sapiens_hsa047280.65989753
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64678864
85Hepatitis B_Homo sapiens_hsa051610.64010505
86Adherens junction_Homo sapiens_hsa045200.63443606
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62293535
88GABAergic synapse_Homo sapiens_hsa047270.62014524
89Endometrial cancer_Homo sapiens_hsa052130.61568411
90VEGF signaling pathway_Homo sapiens_hsa043700.61404198
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.60227451
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59188804
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56960201
94Prolactin signaling pathway_Homo sapiens_hsa049170.56750574
95Acute myeloid leukemia_Homo sapiens_hsa052210.55809773
96Shigellosis_Homo sapiens_hsa051310.54746644
97Ovarian steroidogenesis_Homo sapiens_hsa049130.53574450
98N-Glycan biosynthesis_Homo sapiens_hsa005100.52063930
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.50694500
100Carbon metabolism_Homo sapiens_hsa012000.50672694
101Prostate cancer_Homo sapiens_hsa052150.50286513
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.49741053
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48704141
104Apoptosis_Homo sapiens_hsa042100.48546558
105Gap junction_Homo sapiens_hsa045400.48169788
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46825801
107ErbB signaling pathway_Homo sapiens_hsa040120.46445077
108Choline metabolism in cancer_Homo sapiens_hsa052310.45802833
109Bladder cancer_Homo sapiens_hsa052190.45636323
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44319007
111Tight junction_Homo sapiens_hsa045300.43961286
112Hedgehog signaling pathway_Homo sapiens_hsa043400.43680588
113Fatty acid metabolism_Homo sapiens_hsa012120.43646304
114Primary immunodeficiency_Homo sapiens_hsa053400.43464971
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43184462
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43165734
117Sulfur relay system_Homo sapiens_hsa041220.43160620
118Measles_Homo sapiens_hsa051620.42822075
119Basal cell carcinoma_Homo sapiens_hsa052170.42015206
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.41918274
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41340023
122Non-small cell lung cancer_Homo sapiens_hsa052230.40299166
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38854705
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38768584
125Influenza A_Homo sapiens_hsa051640.37993552
126Inositol phosphate metabolism_Homo sapiens_hsa005620.37595203
127Collecting duct acid secretion_Homo sapiens_hsa049660.37272430
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37241347
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36947166
130Legionellosis_Homo sapiens_hsa051340.36685737
131Wnt signaling pathway_Homo sapiens_hsa043100.36229005
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35358194
133Pathways in cancer_Homo sapiens_hsa052000.34526223
134Arginine and proline metabolism_Homo sapiens_hsa003300.33043449
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33028602
136HIF-1 signaling pathway_Homo sapiens_hsa040660.32478290
137Linoleic acid metabolism_Homo sapiens_hsa005910.32024243
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.31307878
139Lysine degradation_Homo sapiens_hsa003100.30294109
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.30218458
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.30192435
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30125862
143TNF signaling pathway_Homo sapiens_hsa046680.30099157
144MAPK signaling pathway_Homo sapiens_hsa040100.29316494
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27199743
146AMPK signaling pathway_Homo sapiens_hsa041520.27022017

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