CRY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.14698310
2synaptic vesicle maturation (GO:0016188)4.84869317
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73356140
4synaptic vesicle exocytosis (GO:0016079)4.61436185
5locomotory exploration behavior (GO:0035641)4.58440330
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.53282636
7regulation of synaptic vesicle exocytosis (GO:2000300)4.45292772
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.35816314
9cellular potassium ion homeostasis (GO:0030007)4.33402913
10glutamate secretion (GO:0014047)4.31243817
11vocalization behavior (GO:0071625)4.09604513
12regulation of synaptic vesicle transport (GO:1902803)4.04005873
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99571933
14sarcoplasmic reticulum calcium ion transport (GO:0070296)3.93391014
15creatine metabolic process (GO:0006600)3.88249765
16neurotransmitter-gated ion channel clustering (GO:0072578)3.87314986
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.83331486
18neurotransmitter secretion (GO:0007269)3.80530714
19regulation of glutamate receptor signaling pathway (GO:1900449)3.77459087
20cell communication by electrical coupling (GO:0010644)3.76159425
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71781224
22protein localization to synapse (GO:0035418)3.69290436
23muscle filament sliding (GO:0030049)3.65715205
24actin-myosin filament sliding (GO:0033275)3.65715205
25sodium ion export (GO:0071436)3.59128216
26response to pheromone (GO:0019236)3.54423564
27cardiac muscle contraction (GO:0060048)3.50900216
28regulation of synapse structural plasticity (GO:0051823)3.48780353
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.48064823
30synaptic transmission, glutamatergic (GO:0035249)3.47015964
31neuronal action potential propagation (GO:0019227)3.43304354
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.43142277
33regulation of neuronal synaptic plasticity (GO:0048168)3.43068568
34cerebellar granule cell differentiation (GO:0021707)3.41456005
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38099695
36striated muscle contraction (GO:0006941)3.34677696
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.33915542
38glutamate receptor signaling pathway (GO:0007215)3.32971848
39exploration behavior (GO:0035640)3.32686047
40layer formation in cerebral cortex (GO:0021819)3.32397520
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29533334
42positive regulation of synaptic transmission, GABAergic (GO:0032230)3.29419365
43regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.28424270
44synaptic vesicle endocytosis (GO:0048488)3.27889251
45long-term memory (GO:0007616)3.27158056
46alanine transport (GO:0032328)3.25986259
47neuron-neuron synaptic transmission (GO:0007270)3.25037484
48positive regulation of synapse maturation (GO:0090129)3.23524772
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.22536345
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.21161174
51myofibril assembly (GO:0030239)3.19985271
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19381534
53neuron cell-cell adhesion (GO:0007158)3.19146438
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19025859
55potassium ion homeostasis (GO:0055075)3.16291202
56regulation of relaxation of muscle (GO:1901077)3.16202962
57gamma-aminobutyric acid transport (GO:0015812)3.11889669
58innervation (GO:0060384)3.10563930
59neurotransmitter transport (GO:0006836)3.10217047
60proline transport (GO:0015824)3.09986124
61regulation of cell communication by electrical coupling (GO:0010649)3.09803863
62skeletal muscle contraction (GO:0003009)3.08984907
63regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.07989102
64membrane depolarization during action potential (GO:0086010)3.06859103
65regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05450791
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.01980124
67detection of calcium ion (GO:0005513)3.01522479
68regulation of neurotransmitter secretion (GO:0046928)3.00099205
69activation of protein kinase A activity (GO:0034199)2.99735481
70positive regulation of membrane potential (GO:0045838)2.99239170
71cellular sodium ion homeostasis (GO:0006883)2.99215652
72ethanol oxidation (GO:0006069)2.98265524
73regulation of actin filament-based movement (GO:1903115)2.97742119
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95800301
75regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94725570
76long-term synaptic potentiation (GO:0060291)2.94561005
77long term synaptic depression (GO:0060292)2.94449532
78regulation of vesicle fusion (GO:0031338)2.93681860
79dendritic spine morphogenesis (GO:0060997)2.92231574
80cerebellar Purkinje cell differentiation (GO:0021702)2.90904780
81cardiac muscle hypertrophy (GO:0003300)2.90414621
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87265879
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86664583
84glycine transport (GO:0015816)2.86306624
85regulation of postsynaptic membrane potential (GO:0060078)2.85989084
86regulation of neurotransmitter levels (GO:0001505)2.85189381
87response to auditory stimulus (GO:0010996)2.84484164
88actin-mediated cell contraction (GO:0070252)2.84341751
89regulation of synaptic plasticity (GO:0048167)2.83838747
90striated muscle hypertrophy (GO:0014897)2.81222792
91cardiac myofibril assembly (GO:0055003)2.80246765
92regulation of neurotransmitter transport (GO:0051588)2.80087747
93NADH metabolic process (GO:0006734)2.79392131
94L-amino acid import (GO:0043092)2.78520927
95synapse assembly (GO:0007416)2.78026608
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77854859
97cell communication involved in cardiac conduction (GO:0086065)2.76399210
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.75746914
99membrane hyperpolarization (GO:0060081)2.74909731
100neuromuscular process controlling posture (GO:0050884)2.74783640
101regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.74673402
102regulation of ARF protein signal transduction (GO:0032012)2.73223746
103potassium ion import (GO:0010107)2.69894454
104response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.69890664
105positive regulation of neurotransmitter transport (GO:0051590)2.69508022
106chemosensory behavior (GO:0007635)2.67586817
1072-oxoglutarate metabolic process (GO:0006103)2.67272929
108cardiac muscle hypertrophy in response to stress (GO:0014898)2.67096661
109muscle hypertrophy in response to stress (GO:0003299)2.67096661
110cardiac muscle adaptation (GO:0014887)2.67096661
111positive regulation of neurotransmitter secretion (GO:0001956)2.66840445
112regulation of dendritic spine morphogenesis (GO:0061001)2.65523713
113positive regulation of dendritic spine morphogenesis (GO:0061003)2.64755911
114dendrite morphogenesis (GO:0048813)2.64636393
115auditory behavior (GO:0031223)2.64615437
116prepulse inhibition (GO:0060134)2.63420939
117transmission of nerve impulse (GO:0019226)2.63338094
118positive regulation of potassium ion transmembrane transport (GO:1901381)2.62057005
119positive regulation of dendritic spine development (GO:0060999)2.61521680
120positive regulation of synaptic transmission (GO:0050806)2.60461985
121positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.60376695
122muscle hypertrophy (GO:0014896)2.59912354
123membrane depolarization (GO:0051899)2.59698171
124striatum development (GO:0021756)2.59031699
125behavioral response to cocaine (GO:0048148)2.58887155
126regulation of synapse maturation (GO:0090128)2.58875968
127regulation of voltage-gated calcium channel activity (GO:1901385)2.58407657
128regulation of skeletal muscle contraction (GO:0014819)2.56545289
129neuromuscular process controlling balance (GO:0050885)2.56380944
130sarcomere organization (GO:0045214)2.55428411
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55324085
132regulation of membrane repolarization (GO:0060306)2.54482166
133urinary tract smooth muscle contraction (GO:0014848)2.53258085
134regulation of calcium ion transmembrane transporter activity (GO:1901019)2.52954783
135regulation of calcium ion transmembrane transport (GO:1903169)2.52954783
136synaptic transmission (GO:0007268)2.52579599
137amino acid import (GO:0043090)2.52055740
138macroautophagy (GO:0016236)2.52022881
139cellular response to epinephrine stimulus (GO:0071872)2.49205410
140ethanol metabolic process (GO:0006067)2.47204317
141cytoskeletal anchoring at plasma membrane (GO:0007016)2.43207981
142striated muscle adaptation (GO:0014888)2.42327988
143regulation of sequestering of triglyceride (GO:0010889)2.39776500
144neuronal ion channel clustering (GO:0045161)2.39655914
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.37027282
146carnitine shuttle (GO:0006853)2.36325573
147actin filament-based movement (GO:0030048)2.35369001
148response to mercury ion (GO:0046689)2.33761348
149regulation of sodium ion transmembrane transporter activity (GO:2000649)2.31399265
150skeletal muscle adaptation (GO:0043501)2.30338827
151regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.30296320
152complement activation, alternative pathway (GO:0006957)2.28790997
153muscle contraction (GO:0006936)2.28680971
154cellular response to catecholamine stimulus (GO:0071870)2.28070615
155cellular response to monoamine stimulus (GO:0071868)2.28070615
156regulation of sodium ion transmembrane transport (GO:1902305)2.27915483
157dicarboxylic acid biosynthetic process (GO:0043650)2.27241367
158oxaloacetate metabolic process (GO:0006107)2.24651974
159fatty acid transmembrane transport (GO:1902001)2.23789616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89250521
2GBX2_23144817_ChIP-Seq_PC3_Human3.26510125
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82077999
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76994783
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.64664430
6DROSHA_22980978_ChIP-Seq_HELA_Human2.61003601
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53580399
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47756941
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43915756
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38051745
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38051745
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36777594
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.32253815
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31602950
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29789293
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25014210
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21799086
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.18892922
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.18013081
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14098156
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.12307553
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.09770109
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.00587604
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91154135
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.87429322
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.85148721
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73915268
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68506131
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68104821
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67882805
31AR_21572438_ChIP-Seq_LNCaP_Human1.64128551
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63083519
33LXR_22292898_ChIP-Seq_THP-1_Human1.59640332
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57105072
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.55422830
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52296124
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.49396653
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49379711
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.48335650
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48269459
41SMAD4_21799915_ChIP-Seq_A2780_Human1.47622953
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40443981
43* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39133892
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.36329699
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.35694085
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.35694085
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.33892262
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33092154
49* SMC4_20622854_ChIP-Seq_HELA_Human1.33079718
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32532333
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29445488
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29366851
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29257156
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28964801
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28638411
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.27760719
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.25463240
58AR_19668381_ChIP-Seq_PC3_Human1.24998428
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23606877
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22450413
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21825592
62* KDM2B_26808549_Chip-Seq_DND41_Human1.21532335
63STAT3_23295773_ChIP-Seq_U87_Human1.18875458
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16068902
65ZNF274_21170338_ChIP-Seq_K562_Hela1.15707488
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14699684
67AR_25329375_ChIP-Seq_VCAP_Human1.14676010
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14387467
69TCF7_22412390_ChIP-Seq_EML_Mouse1.13879807
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.13627277
71P300_19829295_ChIP-Seq_ESCs_Human1.13477858
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13250047
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12509011
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.12225590
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11516201
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.09494704
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.08278103
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07457772
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05969264
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05188443
81* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04518867
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.04332446
83* CREB1_26743006_Chip-Seq_LNCaP_Human1.04324000
84SMAD4_21741376_ChIP-Seq_HESCs_Human1.03240952
85* KDM2B_26808549_Chip-Seq_K562_Human1.02866905
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02632641
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02505527
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02369486
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02205757
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01977155
91OCT4_19829295_ChIP-Seq_ESCs_Human1.01175021
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01061870
93TCF4_23295773_ChIP-Seq_U87_Human1.00757399
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00558279
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00263258
96CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99724726
97BCAT_22108803_ChIP-Seq_LS180_Human0.99678103
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.98898223
99GATA1_19941826_ChIP-Seq_K562_Human0.98869045
100TAF15_26573619_Chip-Seq_HEK293_Human0.97808313
101YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97706850
102* FOXA2_19822575_ChIP-Seq_HepG2_Human0.97531579
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97013441
104CTCF_27219007_Chip-Seq_Bcells_Human0.96284094
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96073907
106TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95878797
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95440897
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94810053
109BP1_19119308_ChIP-ChIP_Hs578T_Human0.94705810
110CBX2_27304074_Chip-Seq_ESCs_Mouse0.94679543
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.94289835
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.93949357
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93733147
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.93292949
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93089808
116* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92602286
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92596028
118* P68_20966046_ChIP-Seq_HELA_Human0.92217411
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91266236
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91116739
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.91060287
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90956951
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90798204
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90736035
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.90578978
126CLOCK_20551151_ChIP-Seq_293T_Human0.89305210
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88924910
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88720314
129RACK7_27058665_Chip-Seq_MCF-7_Human0.88690550
130IGF1R_20145208_ChIP-Seq_DFB_Human0.88215921
131RUNX2_22187159_ChIP-Seq_PCA_Human0.87228918
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86923209
133* KDM2B_26808549_Chip-Seq_JURKAT_Human0.86878047
134AHR_22903824_ChIP-Seq_MCF-7_Human0.86317492
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85551544
136KLF4_19829295_ChIP-Seq_ESCs_Human0.84926323
137* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84231636
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.83915105
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83783471
140TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83493612
141ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82924078
142RXR_22108803_ChIP-Seq_LS180_Human0.81055489
143ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80937472
144TP63_22573176_ChIP-Seq_HFKS_Human0.80327026
145* SA1_27219007_Chip-Seq_ERYTHROID_Human0.80208502
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79959456
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79273912
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.79061032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.12772389
2MP0003635_abnormal_synaptic_transmissio3.45347704
3MP0003880_abnormal_central_pattern3.32907784
4MP0004270_analgesia3.13287999
5MP0002822_catalepsy2.83004559
6MP0009745_abnormal_behavioral_response2.74750748
7MP0002063_abnormal_learning/memory/cond2.72743641
8MP0009780_abnormal_chondrocyte_physiolo2.64302759
9MP0002909_abnormal_adrenal_gland2.57570081
10MP0009046_muscle_twitch2.57167645
11MP0002064_seizures2.56526339
12MP0003646_muscle_fatigue2.55618868
13MP0001968_abnormal_touch/_nociception2.39317927
14MP0002572_abnormal_emotion/affect_behav2.38658059
15MP0002272_abnormal_nervous_system2.27956856
16MP0000749_muscle_degeneration2.26992369
17MP0001486_abnormal_startle_reflex2.26177376
18MP0002734_abnormal_mechanical_nocicepti2.22827054
19MP0001984_abnormal_olfaction2.20012901
20MP0005646_abnormal_pituitary_gland2.19113464
21MP0005423_abnormal_somatic_nervous2.17903535
22MP0001501_abnormal_sleep_pattern1.99148721
23MP0004510_myositis1.98645570
24MP0004858_abnormal_nervous_system1.97776903
25MP0004087_abnormal_muscle_fiber1.91162849
26MP0002332_abnormal_exercise_endurance1.88733363
27MP0005551_abnormal_eye_electrophysiolog1.85876626
28MP0003329_amyloid_beta_deposits1.84050398
29MP0003879_abnormal_hair_cell1.81427531
30MP0001440_abnormal_grooming_behavior1.80885253
31MP0004084_abnormal_cardiac_muscle1.80727479
32MP0002736_abnormal_nociception_after1.80329148
33MP0000747_muscle_weakness1.79186976
34MP0005645_abnormal_hypothalamus_physiol1.78293091
35MP0002106_abnormal_muscle_physiology1.76919236
36MP0008569_lethality_at_weaning1.73659881
37MP0002733_abnormal_thermal_nociception1.73330574
38* MP0001502_abnormal_circadian_rhythm1.72013734
39MP0000013_abnormal_adipose_tissue1.71102135
40MP0000759_abnormal_skeletal_muscle1.68711802
41MP0002067_abnormal_sensory_capabilities1.67664197
42MP0002735_abnormal_chemical_nociception1.66294551
43MP0010386_abnormal_urinary_bladder1.65751908
44MP0002837_dystrophic_cardiac_calcinosis1.63455608
45MP0002557_abnormal_social/conspecific_i1.62162536
46MP0005451_abnormal_body_composition1.60690582
47MP0002971_abnormal_brown_adipose1.58496069
48MP0001970_abnormal_pain_threshold1.56630795
49MP0005620_abnormal_muscle_contractility1.56176430
50MP0002184_abnormal_innervation1.53880843
51MP0006276_abnormal_autonomic_nervous1.53421905
52MP0005369_muscle_phenotype1.53174367
53MP0005386_behavior/neurological_phenoty1.51533929
54MP0004924_abnormal_behavior1.51533929
55MP0005666_abnormal_adipose_tissue1.49748235
56MP0002972_abnormal_cardiac_muscle1.48134180
57MP0004484_altered_response_of1.47363400
58MP0002269_muscular_atrophy1.41017318
59MP0004885_abnormal_endolymph1.37629917
60MP0005375_adipose_tissue_phenotype1.35273784
61MP0004043_abnormal_pH_regulation1.33861351
62MP0002090_abnormal_vision1.32915338
63MP0008961_abnormal_basal_metabolism1.32141318
64MP0000750_abnormal_muscle_regeneration1.31338305
65MP0003633_abnormal_nervous_system1.31257464
66MP0005330_cardiomyopathy1.31176269
67MP0004145_abnormal_muscle_electrophysio1.30107844
68MP0004811_abnormal_neuron_physiology1.28935581
69MP0000955_abnormal_spinal_cord1.28898380
70MP0005365_abnormal_bile_salt1.21853002
71MP0006138_congestive_heart_failure1.21680319
72MP0000751_myopathy1.20395958
73MP0004233_abnormal_muscle_weight1.19521832
74MP0002882_abnormal_neuron_morphology1.19384395
75MP0006072_abnormal_retinal_apoptosis1.19225891
76MP0008875_abnormal_xenobiotic_pharmacok1.18067368
77MP0002066_abnormal_motor_capabilities/c1.16477685
78MP0005167_abnormal_blood-brain_barrier1.14712472
79MP0003183_abnormal_peptide_metabolism1.14494675
80MP0005535_abnormal_body_temperature1.11777056
81MP0003195_calcinosis1.09489572
82MP0002108_abnormal_muscle_morphology1.08288381
83MP0003283_abnormal_digestive_organ1.07999417
84MP0002229_neurodegeneration1.07974432
85MP0009840_abnormal_foam_cell1.07007041
86MP0003122_maternal_imprinting1.06472408
87MP0004215_abnormal_myocardial_fiber1.05836737
88MP0010630_abnormal_cardiac_muscle1.05649877
89MP0002139_abnormal_hepatobiliary_system1.03301652
90MP0001544_abnormal_cardiovascular_syste1.03140592
91MP0005385_cardiovascular_system_phenoty1.03140592
92MP0000920_abnormal_myelination1.02311091
93MP0000778_abnormal_nervous_system1.02103869
94MP0006292_abnormal_olfactory_placode1.01192682
95MP0002069_abnormal_eating/drinking_beha1.01000312
96MP0004142_abnormal_muscle_tone0.99694852
97MP0001529_abnormal_vocalization0.97993803
98MP0003631_nervous_system_phenotype0.97701323
99MP0004085_abnormal_heartbeat0.96912619
100MP0003787_abnormal_imprinting0.96599205
101MP0002118_abnormal_lipid_homeostasis0.96069786
102MP0005253_abnormal_eye_physiology0.95861920
103MP0005670_abnormal_white_adipose0.95800981
104MP0003868_abnormal_feces_composition0.94815642
105MP0002078_abnormal_glucose_homeostasis0.92243150
106MP0002234_abnormal_pharynx_morphology0.91005921
107MP0003303_peritoneal_inflammation0.90465471
108MP0005379_endocrine/exocrine_gland_phen0.89409016
109MP0010329_abnormal_lipoprotein_level0.89170450
110MP0004130_abnormal_muscle_cell0.88931188
111MP0000631_abnormal_neuroendocrine_gland0.86932912
112MP0003690_abnormal_glial_cell0.86241711
113MP0001944_abnormal_pancreas_morphology0.85517662
114MP0004036_abnormal_muscle_relaxation0.82627497
115MP0000003_abnormal_adipose_tissue0.82386176
116MP0003045_fibrosis0.82206137
117MP0002152_abnormal_brain_morphology0.81771738
118MP0003137_abnormal_impulse_conducting0.81694826
119MP0003191_abnormal_cellular_cholesterol0.80295527
120MP0005085_abnormal_gallbladder_physiolo0.79832002
121MP0003634_abnormal_glial_cell0.79241785
122MP0000604_amyloidosis0.78663475
123MP0005448_abnormal_energy_balance0.77014551
124MP0003828_pulmonary_edema0.76952225
125MP0001177_atelectasis0.76812863
126* MP0002638_abnormal_pupillary_reflex0.75886505
127MP0002876_abnormal_thyroid_physiology0.75653852
128MP0008872_abnormal_physiological_respon0.75017987
129MP0003075_altered_response_to0.75001295
130MP0005334_abnormal_fat_pad0.74907603
131MP0008874_decreased_physiological_sensi0.74630982
132MP0005409_darkened_coat_color0.74556642
133MP0000678_abnormal_parathyroid_gland0.74424273
134MP0003953_abnormal_hormone_level0.74379897
135MP0002693_abnormal_pancreas_physiology0.73360524
136MP0009115_abnormal_fat_cell0.73035255
137MP0001188_hyperpigmentation0.72558107
138MP0005166_decreased_susceptibility_to0.69973865
139MP0001905_abnormal_dopamine_level0.68946235
140MP0003656_abnormal_erythrocyte_physiolo0.68630269

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.59553204
2Myokymia (HP:0002411)5.03450949
3Muscle fiber inclusion bodies (HP:0100299)4.95674275
4Nemaline bodies (HP:0003798)4.75972645
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.74984141
6Muscle fiber splitting (HP:0003555)4.63003470
7Visual hallucinations (HP:0002367)4.51567986
8Type 1 muscle fiber predominance (HP:0003803)4.42286042
9Epileptic encephalopathy (HP:0200134)4.37013551
10Focal seizures (HP:0007359)4.21416134
11Hyporeflexia of lower limbs (HP:0002600)3.94019270
12Febrile seizures (HP:0002373)3.78270330
13Progressive cerebellar ataxia (HP:0002073)3.68274872
14Sudden death (HP:0001699)3.67830712
15EMG: myopathic abnormalities (HP:0003458)3.55616744
16Absence seizures (HP:0002121)3.53178300
17Action tremor (HP:0002345)3.52965764
18Exercise-induced muscle cramps (HP:0003710)3.49685530
19Asymmetric septal hypertrophy (HP:0001670)3.46021480
20Generalized tonic-clonic seizures (HP:0002069)3.44248929
21Obstructive sleep apnea (HP:0002870)3.37136966
22Supranuclear gaze palsy (HP:0000605)3.29789682
23Difficulty running (HP:0009046)3.22121301
24Atonic seizures (HP:0010819)3.18648815
25Depression (HP:0000716)3.14351224
26Dialeptic seizures (HP:0011146)3.11785654
27Muscle hypertrophy of the lower extremities (HP:0008968)3.11577731
28EEG with generalized epileptiform discharges (HP:0011198)3.10841322
29Myopathic facies (HP:0002058)3.10387694
30Epileptiform EEG discharges (HP:0011182)3.10268243
31Centrally nucleated skeletal muscle fibers (HP:0003687)3.03000896
32Increased variability in muscle fiber diameter (HP:0003557)3.02325920
33Abnormality of the calf musculature (HP:0001430)3.01797570
34Abnormality of skeletal muscle fiber size (HP:0012084)2.99512441
35Distal lower limb muscle weakness (HP:0009053)2.99219363
36Anxiety (HP:0000739)2.95298628
37Dysdiadochokinesis (HP:0002075)2.94917518
38Calf muscle hypertrophy (HP:0008981)2.87124954
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.82781301
40Postural instability (HP:0002172)2.82773389
41Abnormal atrioventricular conduction (HP:0005150)2.81759252
42Hypsarrhythmia (HP:0002521)2.80579179
43Myoglobinuria (HP:0002913)2.80557733
44Abnormality of the left ventricular outflow tract (HP:0011103)2.79905728
45Subaortic stenosis (HP:0001682)2.79905728
46Hemiparesis (HP:0001269)2.78117318
47Complement deficiency (HP:0004431)2.77914596
48Increased connective tissue (HP:0009025)2.76222876
49Rhabdomyolysis (HP:0003201)2.75281232
50Congenital stationary night blindness (HP:0007642)2.75268462
51EMG: neuropathic changes (HP:0003445)2.73365281
52Central scotoma (HP:0000603)2.70551965
53Truncal ataxia (HP:0002078)2.67466335
54Hyperinsulinemic hypoglycemia (HP:0000825)2.65930560
55Neck muscle weakness (HP:0000467)2.65851408
56Round ear (HP:0100830)2.65385365
57Poor eye contact (HP:0000817)2.64716672
58Neurofibrillary tangles (HP:0002185)2.64070567
59Ankle clonus (HP:0011448)2.63100883
60Hypoglycemic seizures (HP:0002173)2.63002997
61Abnormality of the lower motor neuron (HP:0002366)2.62679833
62Frequent falls (HP:0002359)2.60685099
63Gaze-evoked nystagmus (HP:0000640)2.54217594
64Impaired social interactions (HP:0000735)2.53702427
65Abnormal social behavior (HP:0012433)2.53702427
66Distal arthrogryposis (HP:0005684)2.52721593
67Genetic anticipation (HP:0003743)2.49516531
68Ketoacidosis (HP:0001993)2.49375336
69Atrioventricular block (HP:0001678)2.48694985
70Hyperkalemia (HP:0002153)2.48368308
71Exercise-induced myalgia (HP:0003738)2.48354376
72Torticollis (HP:0000473)2.48295391
73Dysmetria (HP:0001310)2.46159099
74Status epilepticus (HP:0002133)2.45868884
75Megalencephaly (HP:0001355)2.44861590
76Abnormality of the foot musculature (HP:0001436)2.43238692
77Impaired smooth pursuit (HP:0007772)2.42209079
78Impaired vibration sensation in the lower limbs (HP:0002166)2.41671976
79Hyperventilation (HP:0002883)2.40478382
80Foot dorsiflexor weakness (HP:0009027)2.39324423
81Rimmed vacuoles (HP:0003805)2.36241191
82Cerebral inclusion bodies (HP:0100314)2.35105228
83Prolonged QT interval (HP:0001657)2.35031231
84Fetal akinesia sequence (HP:0001989)2.32475152
85Focal dystonia (HP:0004373)2.30088100
86Abnormal eating behavior (HP:0100738)2.28912670
87Abnormality of calcium-phosphate metabolism (HP:0100530)2.26986635
88Bradykinesia (HP:0002067)2.25779748
89Mildly elevated creatine phosphokinase (HP:0008180)2.25376397
90Hemiplegia (HP:0002301)2.25177309
91Ventricular arrhythmia (HP:0004308)2.24897298
92Abnormality of macular pigmentation (HP:0008002)2.24896156
93Ventricular tachycardia (HP:0004756)2.24159648
94Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23425218
95Agitation (HP:0000713)2.20849070
96Abnormal EKG (HP:0003115)2.18922713
97Excessive salivation (HP:0003781)2.18154223
98Drooling (HP:0002307)2.18154223
99Urinary bladder sphincter dysfunction (HP:0002839)2.17622807
100Ventricular fibrillation (HP:0001663)2.17202559
101Muscle stiffness (HP:0003552)2.17182207
102Ulnar deviation of the wrist (HP:0003049)2.15780809
103Scanning speech (HP:0002168)2.15575298
104Broad-based gait (HP:0002136)2.12530210
105Abnormality of ocular smooth pursuit (HP:0000617)2.11460388
106Bundle branch block (HP:0011710)2.10124057
107Lower limb amyotrophy (HP:0007210)2.09526407
108Pheochromocytoma (HP:0002666)2.09418469
109Distal lower limb amyotrophy (HP:0008944)2.09206188
110Hyperlipoproteinemia (HP:0010980)2.09166095
111Craniofacial dystonia (HP:0012179)2.08835356
112Atrial fibrillation (HP:0005110)2.08713645
113Oligomenorrhea (HP:0000876)2.07916394
114Rapidly progressive (HP:0003678)2.06778133
115Symptomatic seizures (HP:0011145)2.06642623
116Abnormality of complement system (HP:0005339)2.05608569
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04356140
118Neoplasm of the heart (HP:0100544)2.04029511
119Myotonia (HP:0002486)2.03907711
120Deep venous thrombosis (HP:0002625)1.99692223
121Dysmetric saccades (HP:0000641)1.99450105
122Stereotypic behavior (HP:0000733)1.98696592
123Primary atrial arrhythmia (HP:0001692)1.98435147
124Intention tremor (HP:0002080)1.97768700
125Difficulty climbing stairs (HP:0003551)1.96480299
126Ketosis (HP:0001946)1.95187455
127Syncope (HP:0001279)1.95059656
128Hypoglycemic coma (HP:0001325)1.95028774
129Spastic gait (HP:0002064)1.94234483
130Decreased circulating renin level (HP:0003351)1.93821338
131Hypercortisolism (HP:0001578)1.93144276
132Aplasia of the phalanges of the hand (HP:0009802)1.92661534
133Aplasia involving bones of the extremities (HP:0009825)1.92661534
134Aplasia involving bones of the upper limbs (HP:0009823)1.92661534
135Insomnia (HP:0100785)1.92135677
136Sleep apnea (HP:0010535)1.92110292
137Scotoma (HP:0000575)1.91091323
138Abnormality of binocular vision (HP:0011514)1.90727754
139Diplopia (HP:0000651)1.90727754
140Rigidity (HP:0002063)1.90354743
141Neuronal loss in central nervous system (HP:0002529)1.90316887
142Systemic lupus erythematosus (HP:0002725)1.89562107
143Amblyopia (HP:0000646)1.89432403
144Gowers sign (HP:0003391)1.88984800
145Scapular winging (HP:0003691)1.88485580
146Stridor (HP:0010307)1.86331287
147Blue irides (HP:0000635)1.86020480
148Supraventricular tachycardia (HP:0004755)1.84871351
149Limb ataxia (HP:0002070)1.83080111
150Impaired vibratory sensation (HP:0002495)1.82273176
151Dilated cardiomyopathy (HP:0001644)1.80823951
152Lower limb muscle weakness (HP:0007340)1.80338595
153Bulbar palsy (HP:0001283)1.79801262
154Joint hemorrhage (HP:0005261)1.79661466
155Late onset (HP:0003584)1.79479865
156Lipoatrophy (HP:0100578)1.79468469
157Supraventricular arrhythmia (HP:0005115)1.78714013
158Gait ataxia (HP:0002066)1.77818277
159Large for gestational age (HP:0001520)1.75852371
160Papilledema (HP:0001085)1.72666439
161Clonus (HP:0002169)1.71255309
162Urinary urgency (HP:0000012)1.71010147
163Retinal atrophy (HP:0001105)1.69679933
164Heart block (HP:0012722)1.69485041
165Hyperglycemia (HP:0003074)1.68935608
166Polyphagia (HP:0002591)1.68716159
167Neuroendocrine neoplasm (HP:0100634)1.68338155
168Global brain atrophy (HP:0002283)1.66198483
169Abnormal gallbladder physiology (HP:0012438)1.65773594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.10578873
2EPHA44.10547227
3OBSCN3.75348629
4MAP3K92.93636183
5MAP3K42.62458249
6PRKD32.54845108
7TTN2.53615875
8DAPK22.51265238
9MINK12.43167871
10MARK12.29045948
11NTRK22.22548537
12PAK62.15075947
13INSRR2.13794622
14MAP2K71.97203287
15PHKG11.86786024
16PHKG21.86786024
17KSR21.84898622
18TNIK1.84495051
19MAP2K41.70741967
20STK381.63737587
21CAMKK11.63450835
22NTRK11.58892125
23PRPF4B1.53899140
24SIK21.47352643
25PINK11.45915605
26LMTK21.45602842
27MAP3K21.41910574
28CDK51.35228375
29RIPK11.33400836
30CAMKK21.28663601
31DAPK11.26759219
32PRKCG1.26278829
33KSR11.25132506
34EEF2K1.18644622
35SGK4941.18461843
36SGK2231.18461843
37ERN11.15863131
38SGK21.15779297
39SIK31.12344319
40MAPK131.10528298
41UHMK11.08457306
42GRK51.04322715
43CAMK11.04253309
44TYRO31.01093272
45SGK31.00628624
46MAP3K131.00477637
47WNK30.99836447
48PAK30.97402631
49PRKCH0.94765079
50SIK10.94669057
51TNK20.93254825
52CAMK2A0.92815414
53MAP3K10.92645728
54PRKAA20.89845586
55MARK20.86793076
56MAPK70.86790555
57ICK0.86470528
58MAPK150.85846157
59MAP3K110.85419434
60EPHA30.84148437
61DYRK1B0.83549501
62MAP3K60.83045415
63RET0.82696153
64RIPK40.82138386
65MAP2K30.81781894
66CDK190.81103786
67CDC42BPA0.80814765
68NME10.80615596
69FGFR20.80389511
70CAMK1G0.79336408
71EPHB10.79305265
72MAP3K70.78869027
73PIK3CG0.77243970
74MAP2K60.77217995
75FES0.74933472
76CASK0.73337873
77CAMK2D0.70629195
78CAMK2B0.69781048
79TAOK10.69222123
80PKN10.68435742
81ARAF0.68010308
82FER0.66835654
83SGK10.64906725
84FGFR40.63347977
85JAK20.63344086
86MAPK40.62900796
87PRKD10.62695160
88LATS20.60957548
89DMPK0.60531414
90CAMK40.60527862
91TAOK20.60346518
92CAMK2G0.58981136
93WNK40.58688345
94AKT30.58529424
95STK110.58321932
96FGFR30.57827591
97NEK10.57384246
98RPS6KA30.56414398
99WNK10.56347357
100PRKAA10.56315850
101* DYRK1A0.56082614
102TRPM70.55693976
103MAPK120.55659458
104CDK180.55189569
105JAK10.54961157
106RPS6KA20.54728403
107PRKCE0.53749790
108PDPK10.53433243
109CDK150.53057848
110TBK10.52839780
111CDK140.52772842
112MAPKAPK30.52069500
113MAP3K30.51737662
114PRKCZ0.51640989
115PNCK0.51241809
116PDK10.49524676
117MUSK0.49503602
118PTK2B0.47588179
119MAP2K10.47505545
120NEK60.47489977
121PLK20.47275133
122TRIB30.46931036
123MAPK100.46488705
124PRKD20.45822809
125IRAK20.45273586
126PDGFRA0.45177862
127CDK11A0.44356829
128HIPK20.44133277
129PRKACG0.42915354
130PRKACA0.42401965
131PIK3CA0.41278907
132PDK20.40159645

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.17077609
2Synaptic vesicle cycle_Homo sapiens_hsa047212.85119987
3GABAergic synapse_Homo sapiens_hsa047272.63050480
4Insulin secretion_Homo sapiens_hsa049112.61530175
5Olfactory transduction_Homo sapiens_hsa047402.48106167
6Circadian entrainment_Homo sapiens_hsa047132.47020109
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35755904
8Morphine addiction_Homo sapiens_hsa050322.25980252
9Glutamatergic synapse_Homo sapiens_hsa047242.15102859
10Nitrogen metabolism_Homo sapiens_hsa009102.11001783
11Amphetamine addiction_Homo sapiens_hsa050312.05462388
12Long-term potentiation_Homo sapiens_hsa047201.99521602
13Phenylalanine metabolism_Homo sapiens_hsa003601.96325308
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94864521
15Salivary secretion_Homo sapiens_hsa049701.89216488
16Dopaminergic synapse_Homo sapiens_hsa047281.80538949
17Taste transduction_Homo sapiens_hsa047421.74225245
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71555130
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71445910
20Cholinergic synapse_Homo sapiens_hsa047251.63691318
21Cocaine addiction_Homo sapiens_hsa050301.60591748
22Renin secretion_Homo sapiens_hsa049241.56354575
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.55311482
24Histidine metabolism_Homo sapiens_hsa003401.54473931
25Gastric acid secretion_Homo sapiens_hsa049711.47626203
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45269591
27Type II diabetes mellitus_Homo sapiens_hsa049301.44428417
28Calcium signaling pathway_Homo sapiens_hsa040201.40688008
29Serotonergic synapse_Homo sapiens_hsa047261.40254309
30Oxytocin signaling pathway_Homo sapiens_hsa049211.33747678
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29976754
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27819577
33Long-term depression_Homo sapiens_hsa047301.19253771
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18876390
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18185676
36cAMP signaling pathway_Homo sapiens_hsa040241.17374453
37Complement and coagulation cascades_Homo sapiens_hsa046101.10993115
38Arginine biosynthesis_Homo sapiens_hsa002201.10591759
39Tyrosine metabolism_Homo sapiens_hsa003501.09264650
40Bile secretion_Homo sapiens_hsa049761.08499687
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07152224
42* Circadian rhythm_Homo sapiens_hsa047101.06981154
43GnRH signaling pathway_Homo sapiens_hsa049121.03979106
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01440355
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99555356
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96867294
47Arginine and proline metabolism_Homo sapiens_hsa003300.96553016
48Glucagon signaling pathway_Homo sapiens_hsa049220.96299684
49Pancreatic secretion_Homo sapiens_hsa049720.95811100
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95575552
51Gap junction_Homo sapiens_hsa045400.95200855
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92455430
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.89343366
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89169573
55Phototransduction_Homo sapiens_hsa047440.89034858
56beta-Alanine metabolism_Homo sapiens_hsa004100.87559908
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.85062394
58Fatty acid biosynthesis_Homo sapiens_hsa000610.84434210
59Collecting duct acid secretion_Homo sapiens_hsa049660.83907735
60Butanoate metabolism_Homo sapiens_hsa006500.83506499
61Cardiac muscle contraction_Homo sapiens_hsa042600.82287866
62Thyroid hormone synthesis_Homo sapiens_hsa049180.80658636
63Estrogen signaling pathway_Homo sapiens_hsa049150.80617376
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77902415
65Dilated cardiomyopathy_Homo sapiens_hsa054140.74057805
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70400262
67Vibrio cholerae infection_Homo sapiens_hsa051100.69827589
68VEGF signaling pathway_Homo sapiens_hsa043700.68965730
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.68937426
70Melanogenesis_Homo sapiens_hsa049160.66026586
71Dorso-ventral axis formation_Homo sapiens_hsa043200.64955415
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.63194199
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62205641
74Linoleic acid metabolism_Homo sapiens_hsa005910.60421769
75Glioma_Homo sapiens_hsa052140.60145842
76Fatty acid metabolism_Homo sapiens_hsa012120.58907334
77ABC transporters_Homo sapiens_hsa020100.58758648
78ErbB signaling pathway_Homo sapiens_hsa040120.57948643
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57135240
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56780463
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56532252
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55202954
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54789570
84Axon guidance_Homo sapiens_hsa043600.54290712
85Fatty acid degradation_Homo sapiens_hsa000710.53781198
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53683712
87Insulin signaling pathway_Homo sapiens_hsa049100.52946305
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.51832932
89Prion diseases_Homo sapiens_hsa050200.51427392
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49383446
91Retinol metabolism_Homo sapiens_hsa008300.49341477
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47521840
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.47504979
94Carbon metabolism_Homo sapiens_hsa012000.47264751
95Type I diabetes mellitus_Homo sapiens_hsa049400.47150365
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47015176
97Inositol phosphate metabolism_Homo sapiens_hsa005620.46894466
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45539473
99PPAR signaling pathway_Homo sapiens_hsa033200.45496904
100Choline metabolism in cancer_Homo sapiens_hsa052310.43876154
101Chemical carcinogenesis_Homo sapiens_hsa052040.43465415
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41147495
103Insulin resistance_Homo sapiens_hsa049310.39708668
104Ovarian steroidogenesis_Homo sapiens_hsa049130.39697250
105Glycerolipid metabolism_Homo sapiens_hsa005610.39168010
106Tryptophan metabolism_Homo sapiens_hsa003800.38754449
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38194930
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37915648
109Tight junction_Homo sapiens_hsa045300.37024732
110MAPK signaling pathway_Homo sapiens_hsa040100.36528710
111mTOR signaling pathway_Homo sapiens_hsa041500.35819422
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35590209
113Fructose and mannose metabolism_Homo sapiens_hsa000510.35332240
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33760516
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.32336980
116AMPK signaling pathway_Homo sapiens_hsa041520.32070018
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30935822
118Sulfur metabolism_Homo sapiens_hsa009200.29265671

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