CRYAB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.61901437
2axon ensheathment in central nervous system (GO:0032291)8.61901437
3sarcomere organization (GO:0045214)6.19408660
4creatine metabolic process (GO:0006600)5.81348455
5negative regulation of protein localization to cell surface (GO:2000009)5.79735590
6myofibril assembly (GO:0030239)5.32747030
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.26355537
8cardiac myofibril assembly (GO:0055003)5.24531417
9muscle filament sliding (GO:0030049)5.17406900
10actin-myosin filament sliding (GO:0033275)5.17406900
11ensheathment of neurons (GO:0007272)5.15468380
12axon ensheathment (GO:0008366)5.15468380
13myelination (GO:0042552)5.06052948
14fatty acid elongation (GO:0030497)4.98119265
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.81464435
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.66767972
17myelin maintenance (GO:0043217)4.62530315
18negative regulation of potassium ion transmembrane transport (GO:1901380)4.57672071
19regulation of actin filament-based movement (GO:1903115)4.42046529
20actin-mediated cell contraction (GO:0070252)4.36449727
21cellular potassium ion homeostasis (GO:0030007)4.28960662
22sodium ion export (GO:0071436)4.25038198
23regulation of skeletal muscle contraction (GO:0014819)4.18256271
24regulation of relaxation of muscle (GO:1901077)4.15676621
25cardiac muscle tissue morphogenesis (GO:0055008)4.13941071
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.13643920
27actomyosin structure organization (GO:0031032)4.08731369
28ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.07056672
29adult heart development (GO:0007512)3.98602940
30cell communication by electrical coupling (GO:0010644)3.95467121
31cardiac muscle contraction (GO:0060048)3.87476015
32long-chain fatty acid biosynthetic process (GO:0042759)3.78214283
33positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.77383654
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.76854954
35muscle tissue morphogenesis (GO:0060415)3.75791196
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.75647892
37plasma membrane repair (GO:0001778)3.75584251
38regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.74118008
39regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.69075523
40potassium ion import (GO:0010107)3.66465455
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63844001
42ATP synthesis coupled proton transport (GO:0015986)3.63844001
43postsynaptic membrane organization (GO:0001941)3.63608324
44establishment of mitochondrion localization (GO:0051654)3.60837593
45astrocyte differentiation (GO:0048708)3.59236462
46sarcoplasmic reticulum calcium ion transport (GO:0070296)3.57952122
47cell communication involved in cardiac conduction (GO:0086065)3.57337820
48regulation of striated muscle contraction (GO:0006942)3.57037287
49cardiac muscle cell development (GO:0055013)3.50406502
50membrane tubulation (GO:0097320)3.50247895
51respiratory electron transport chain (GO:0022904)3.49822728
52response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.49543172
53regulation of cell communication by electrical coupling (GO:0010649)3.47280052
54heart trabecula formation (GO:0060347)3.44139786
55detection of calcium ion (GO:0005513)3.43693502
56regulation of cardiac muscle cell contraction (GO:0086004)3.39431688
57potassium ion homeostasis (GO:0055075)3.39205239
58electron transport chain (GO:0022900)3.38165594
59regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.31637765
60striated muscle contraction (GO:0006941)3.28691694
61cardiac cell development (GO:0055006)3.26447931
62photoreceptor cell differentiation (GO:0046530)3.26389768
63eye photoreceptor cell differentiation (GO:0001754)3.26389768
64regulation of sarcomere organization (GO:0060297)3.25072704
65myelination in peripheral nervous system (GO:0022011)3.23993246
66peripheral nervous system axon ensheathment (GO:0032292)3.23993246
67actin filament-based movement (GO:0030048)3.22347128
68ventricular cardiac muscle cell action potential (GO:0086005)3.22266184
69astrocyte development (GO:0014002)3.21855737
70regulation of cardioblast differentiation (GO:0051890)3.20933281
71regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.20674806
72synaptic vesicle docking involved in exocytosis (GO:0016081)3.20195227
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19962799
74cerebellar granule cell differentiation (GO:0021707)3.19695283
75cellular response to epinephrine stimulus (GO:0071872)3.18574014
76L-amino acid import (GO:0043092)3.16646618
77neuronal ion channel clustering (GO:0045161)3.16185070
78substantia nigra development (GO:0021762)3.13899836
79response to redox state (GO:0051775)3.10796772
80cGMP-mediated signaling (GO:0019934)3.06915286
81response to epinephrine (GO:0071871)3.05078804
82heart contraction (GO:0060047)3.04057790
83heart process (GO:0003015)3.04057790
84regulation of cardiac muscle contraction (GO:0055117)3.03547517
85oligodendrocyte differentiation (GO:0048709)3.03137383
86cardiac muscle hypertrophy (GO:0003300)3.01987071
87regulation of membrane repolarization (GO:0060306)3.01403643
88regulation of lipoprotein metabolic process (GO:0050746)3.00984105
89cellular sodium ion homeostasis (GO:0006883)2.99252740
90bundle of His cell to Purkinje myocyte communication (GO:0086069)2.98631766
91synaptic vesicle maturation (GO:0016188)2.97732748
92positive regulation of action potential (GO:0045760)2.96197645
93apical protein localization (GO:0045176)2.94743892
94regulation of collateral sprouting (GO:0048670)2.94629094
95peptidyl-tyrosine autophosphorylation (GO:0038083)2.93049353
96muscle hypertrophy (GO:0014896)2.92194800
97glutamate secretion (GO:0014047)2.90788826
98striated muscle hypertrophy (GO:0014897)2.90115680
99cardiac muscle hypertrophy in response to stress (GO:0014898)2.89446257
100muscle hypertrophy in response to stress (GO:0003299)2.89446257
101cardiac muscle adaptation (GO:0014887)2.89446257
102asymmetric protein localization (GO:0008105)2.87883654
103adhesion of symbiont to host cell (GO:0044650)2.87525135
104virion attachment to host cell (GO:0019062)2.87525135
105regulation of synapse structural plasticity (GO:0051823)2.85598337
106activation of protein kinase A activity (GO:0034199)2.84708329
107response to inactivity (GO:0014854)2.84571714
108regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.83688910
109neurotransmitter uptake (GO:0001504)2.82801433
110regulation of the force of heart contraction (GO:0002026)2.82564533
111membrane raft organization (GO:0031579)2.82267064
112synaptic vesicle exocytosis (GO:0016079)2.81571838
113vocalization behavior (GO:0071625)2.78655821
114tricarboxylic acid cycle (GO:0006099)2.77352975
115* muscle contraction (GO:0006936)2.76675428
116cholesterol biosynthetic process (GO:0006695)2.74415842
117amino acid import (GO:0043090)2.74294963
118positive regulation of potassium ion transport (GO:0043268)2.73681377
119response to methylmercury (GO:0051597)2.72579217
120relaxation of cardiac muscle (GO:0055119)2.70881799
121neuronal action potential propagation (GO:0019227)2.69491462
122positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.69228011
123regulation of voltage-gated calcium channel activity (GO:1901385)2.68835102
124membrane assembly (GO:0071709)2.68252538
125regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.67817668
126aspartate family amino acid catabolic process (GO:0009068)2.66126733
127locomotory exploration behavior (GO:0035641)2.65828379
128regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64986394
129NADH metabolic process (GO:0006734)2.64961196
130regulation of synaptic vesicle exocytosis (GO:2000300)2.64549867
131regulation of calcium ion transmembrane transporter activity (GO:1901019)2.64195704
132regulation of calcium ion transmembrane transport (GO:1903169)2.64195704
133negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.62474700
134negative regulation of calcium ion transmembrane transport (GO:1903170)2.62474700
135relaxation of muscle (GO:0090075)2.61772867
136negative regulation of neurotransmitter secretion (GO:0046929)2.60202651
137import into cell (GO:0098657)2.58544829
138regulation of sodium ion transmembrane transport (GO:1902305)2.56994085
139negative regulation of neurotransmitter transport (GO:0051589)2.54314336
140* muscle system process (GO:0003012)2.53228614
141cellular response to monoamine stimulus (GO:0071868)2.52971105
142cellular response to catecholamine stimulus (GO:0071870)2.52971105
143response to monoamine (GO:0071867)2.51743581
144response to catecholamine (GO:0071869)2.51743581
145positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.51502677
146thioester biosynthetic process (GO:0035384)2.51305037
147acyl-CoA biosynthetic process (GO:0071616)2.51305037
148negative regulation of inclusion body assembly (GO:0090084)2.51268739
149positive regulation of sodium ion transport (GO:0010765)2.50316219
150skeletal muscle contraction (GO:0003009)2.50252856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse3.11856493
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34373860
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.33164269
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.17701948
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16506991
6EZH2_22144423_ChIP-Seq_EOC_Human2.16233307
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11357324
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.08977475
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.05564219
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05034002
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.02192393
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93790650
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90641209
14* TBX20_22080862_ChIP-Seq_HEART_Mouse1.90050392
15* TBX20_22328084_ChIP-Seq_HEART_Mouse1.90050392
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89473330
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85824516
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85824516
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82874852
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.75980648
21GBX2_23144817_ChIP-Seq_PC3_Human1.72432740
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.72245502
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70927695
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.65057863
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61818766
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54703386
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53676065
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49834752
29DROSHA_22980978_ChIP-Seq_HELA_Human1.49720440
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.49098182
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48603981
32AR_21572438_ChIP-Seq_LNCaP_Human1.48028445
33MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.46042936
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43742754
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43722016
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40372257
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40248832
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36791808
39REST_21632747_ChIP-Seq_MESCs_Mouse1.35822893
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35612671
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35076476
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33847143
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33847143
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33273620
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30657399
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.29104522
47CLOCK_20551151_ChIP-Seq_293T_Human1.28889306
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25563176
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23855963
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23580388
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23260289
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.22529744
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19904025
54KDM2B_26808549_Chip-Seq_K562_Human1.19855763
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19675849
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.18094395
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15994628
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14550858
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13966967
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13135076
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12486166
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11807618
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11768899
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11595971
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.11102003
66EOMES_21245162_ChIP-Seq_HESCs_Human1.10283534
67ER_23166858_ChIP-Seq_MCF-7_Human1.08819756
68VDR_22108803_ChIP-Seq_LS180_Human1.08190524
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07382700
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04121032
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03406139
72AHR_22903824_ChIP-Seq_MCF-7_Human1.02044456
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.01852608
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.00934827
75CTCF_27219007_Chip-Seq_Bcells_Human1.00650890
76NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98631934
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98426943
78GATA2_21666600_ChIP-Seq_HMVEC_Human0.98117496
79RARB_27405468_Chip-Seq_BRAIN_Mouse0.97404658
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.97146702
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96608743
82TP53_20018659_ChIP-ChIP_R1E_Mouse0.95891268
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95701078
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95477249
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95390169
86PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94109631
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93647511
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93358072
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93313444
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92943338
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92403157
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92294946
93TAF15_26573619_Chip-Seq_HEK293_Human0.92182183
94CJUN_26792858_Chip-Seq_BT549_Human0.92067701
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.90618978
96* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90326558
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.90244094
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90068905
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89912818
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89422003
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.89372657
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.89331454
103* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89273274
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.88962259
105GATA1_19941826_ChIP-Seq_K562_Human0.88863369
106SMAD4_21799915_ChIP-Seq_A2780_Human0.87876924
107OCT4_20526341_ChIP-Seq_ESCs_Human0.87793435
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.87411733
109SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86523726
110SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86255242
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85283655
112* TP53_23651856_ChIP-Seq_MEFs_Mouse0.85118339
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85115510
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84411737
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84026640
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83845054
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82960694
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82480213
119* TET1_21490601_ChIP-Seq_MESCs_Mouse0.82138088
120FOXH1_21741376_ChIP-Seq_ESCs_Human0.81903376
121FOXA2_19822575_ChIP-Seq_HepG2_Human0.80858891
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.80186086
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80122581
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.79272419
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79268640
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79105317
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79039039
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78671850
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.78562399
130RING1B_27294783_Chip-Seq_ESCs_Mouse0.78487871
131AR_19668381_ChIP-Seq_PC3_Human0.78461023
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.78275877
133TBL1_22424771_ChIP-Seq_293T_Human0.78196790
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77950206
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77624902
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77165605
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.77003563
138CBP_21632823_ChIP-Seq_H3396_Human0.76588864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.14512826
2MP0004084_abnormal_cardiac_muscle4.25445602
3MP0000751_myopathy4.25158922
4MP0004036_abnormal_muscle_relaxation3.73326392
5MP0003950_abnormal_plasma_membrane3.65340323
6MP0003646_muscle_fatigue3.53038225
7MP0000920_abnormal_myelination3.38300597
8MP0004215_abnormal_myocardial_fiber3.20580705
9* MP0000749_muscle_degeneration3.18206143
10MP0005330_cardiomyopathy3.16179857
11MP0004859_abnormal_synaptic_plasticity3.11712670
12MP0005670_abnormal_white_adipose2.71567971
13MP0003137_abnormal_impulse_conducting2.50546533
14MP0005423_abnormal_somatic_nervous2.49865186
15MP0002972_abnormal_cardiac_muscle2.49765609
16* MP0004087_abnormal_muscle_fiber2.40120022
17MP0004145_abnormal_muscle_electrophysio2.35201061
18MP0005620_abnormal_muscle_contractility2.24619452
19MP0009780_abnormal_chondrocyte_physiolo2.18538258
20MP0008775_abnormal_heart_ventricle2.17823001
21MP0002106_abnormal_muscle_physiology2.04586485
22* MP0000747_muscle_weakness2.02724105
23MP0003635_abnormal_synaptic_transmissio2.01403377
24MP0006138_congestive_heart_failure2.00225596
25MP0000750_abnormal_muscle_regeneration1.90585353
26MP0005167_abnormal_blood-brain_barrier1.84069412
27MP0004484_altered_response_of1.82804201
28MP0005369_muscle_phenotype1.81864011
29MP0001544_abnormal_cardiovascular_syste1.79900014
30MP0005385_cardiovascular_system_phenoty1.79900014
31MP0005623_abnormal_meninges_morphology1.78723846
32MP0004085_abnormal_heartbeat1.76582470
33MP0010630_abnormal_cardiac_muscle1.74105328
34MP0004043_abnormal_pH_regulation1.67096569
35* MP0000759_abnormal_skeletal_muscle1.66871061
36MP0009745_abnormal_behavioral_response1.61898522
37MP0004130_abnormal_muscle_cell1.59373914
38MP0003329_amyloid_beta_deposits1.59244779
39MP0004270_analgesia1.58735301
40MP0002063_abnormal_learning/memory/cond1.56938028
41MP0008438_abnormal_cutaneous_collagen1.54869782
42MP0005171_absent_coat_pigmentation1.53555447
43MP0003806_abnormal_nucleotide_metabolis1.52262817
44* MP0002269_muscular_atrophy1.52045815
45MP0005451_abnormal_body_composition1.50518597
46MP0003690_abnormal_glial_cell1.50464879
47MP0001502_abnormal_circadian_rhythm1.49710507
48MP0003221_abnormal_cardiomyocyte_apopto1.49212859
49MP0001529_abnormal_vocalization1.48782298
50MP0003634_abnormal_glial_cell1.46511940
51MP0004233_abnormal_muscle_weight1.45797399
52MP0003880_abnormal_central_pattern1.44001260
53MP0003879_abnormal_hair_cell1.40968817
54MP0001984_abnormal_olfaction1.34815544
55MP0001501_abnormal_sleep_pattern1.29207836
56MP0003828_pulmonary_edema1.28006539
57MP0002971_abnormal_brown_adipose1.27990534
58MP0002572_abnormal_emotion/affect_behav1.25395221
59MP0004885_abnormal_endolymph1.23546493
60MP0002272_abnormal_nervous_system1.21689238
61MP0006036_abnormal_mitochondrial_physio1.18493828
62MP0003136_yellow_coat_color1.17308822
63MP0001905_abnormal_dopamine_level1.16192025
64MP0004142_abnormal_muscle_tone1.14891014
65MP0001970_abnormal_pain_threshold1.13494477
66MP0002108_abnormal_muscle_morphology1.13341280
67MP0004185_abnormal_adipocyte_glucose1.11355972
68MP0001485_abnormal_pinna_reflex1.07687598
69MP0004272_abnormal_basement_membrane1.03763721
70MP0005666_abnormal_adipose_tissue1.03193731
71MP0002638_abnormal_pupillary_reflex1.02791438
72MP0009046_muscle_twitch1.02368569
73MP0005375_adipose_tissue_phenotype0.99375630
74MP0002229_neurodegeneration0.99226227
75MP0001440_abnormal_grooming_behavior0.98634627
76MP0004742_abnormal_vestibular_system0.98331984
77MP0001486_abnormal_startle_reflex0.97668626
78MP0002332_abnormal_exercise_endurance0.95751543
79MP0002067_abnormal_sensory_capabilities0.95631857
80MP0001299_abnormal_eye_distance/0.94800142
81MP0005595_abnormal_vascular_smooth0.92549880
82MP0000003_abnormal_adipose_tissue0.92192273
83MP0004510_myositis0.91586722
84MP0005535_abnormal_body_temperature0.91003759
85MP0003075_altered_response_to0.90189602
86MP0005165_increased_susceptibility_to0.88922916
87MP0002733_abnormal_thermal_nociception0.87879920
88MP0002127_abnormal_cardiovascular_syste0.86678202
89MP0004147_increased_porphyrin_level0.86059472
90MP0008569_lethality_at_weaning0.84875875
91MP0000733_abnormal_muscle_development0.84684884
92MP0002295_abnormal_pulmonary_circulatio0.83965907
93MP0002064_seizures0.83690126
94MP0000778_abnormal_nervous_system0.83547788
95MP0005409_darkened_coat_color0.83211880
96MP0003705_abnormal_hypodermis_morpholog0.81346903
97MP0003632_abnormal_nervous_system0.80361816
98MP0000230_abnormal_systemic_arterial0.79802298
99MP0001968_abnormal_touch/_nociception0.79597653
100MP0000013_abnormal_adipose_tissue0.79038203
101MP0006276_abnormal_autonomic_nervous0.78619825
102MP0005646_abnormal_pituitary_gland0.75765417
103MP0003279_aneurysm0.75193059
104MP0004134_abnormal_chest_morphology0.74640614
105MP0001958_emphysema0.73835716
106MP0005410_abnormal_fertilization0.73442434
107MP0005503_abnormal_tendon_morphology0.73194276
108MP0002882_abnormal_neuron_morphology0.72394516
109MP0008260_abnormal_autophagy0.71870990
110MP0000383_abnormal_hair_follicle0.71725868
111MP0003631_nervous_system_phenotype0.70851664
112MP0003195_calcinosis0.70459515
113MP0002234_abnormal_pharynx_morphology0.70281080
114MP0000579_abnormal_nail_morphology0.69908574
115MP0000343_altered_response_to0.69606823
116MP0000955_abnormal_spinal_cord0.69141665
117MP0009384_cardiac_valve_regurgitation0.68226902
118MP0010678_abnormal_skin_adnexa0.66045742
119MP0000462_abnormal_digestive_system0.65962055
120MP0005386_behavior/neurological_phenoty0.64599450
121MP0004924_abnormal_behavior0.64599450
122MP0003633_abnormal_nervous_system0.64018525
123MP0005275_abnormal_skin_tensile0.61599733
124MP0005551_abnormal_eye_electrophysiolog0.61303974
125MP0002734_abnormal_mechanical_nocicepti0.60096944
126MP0004381_abnormal_hair_follicle0.59298214
127* MP0002066_abnormal_motor_capabilities/c0.58908086
128MP0005388_respiratory_system_phenotype0.58498654
129MP0002133_abnormal_respiratory_system0.58498654
130MP0000266_abnormal_heart_morphology0.58209998

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.61993815
2Calf muscle hypertrophy (HP:0008981)5.37561459
3Muscle hypertrophy of the lower extremities (HP:0008968)5.32883762
4Exercise-induced myalgia (HP:0003738)4.88905020
5Ventricular tachycardia (HP:0004756)4.77650594
6Exercise-induced muscle cramps (HP:0003710)4.64052877
7Abnormality of the calf musculature (HP:0001430)4.44126567
8Atrial fibrillation (HP:0005110)4.29137391
9* Muscle fiber splitting (HP:0003555)4.14063550
10* Hyporeflexia of lower limbs (HP:0002600)3.93136862
11Primary atrial arrhythmia (HP:0001692)3.92392664
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.91412060
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.91412060
14Supraventricular tachycardia (HP:0004755)3.74813200
15Difficulty running (HP:0009046)3.71623448
16Supraventricular arrhythmia (HP:0005115)3.68180706
17Neurofibrillary tangles (HP:0002185)3.53145262
18* Lipoatrophy (HP:0100578)3.47574238
19* EMG: myopathic abnormalities (HP:0003458)3.38246137
20Abnormality of the left ventricular outflow tract (HP:0011103)3.33154789
21Subaortic stenosis (HP:0001682)3.33154789
22Prolonged QT interval (HP:0001657)3.28734069
23* Dilated cardiomyopathy (HP:0001644)3.18161459
24EMG: neuropathic changes (HP:0003445)3.17957941
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.16488459
26Syncope (HP:0001279)3.16054647
27Muscle fiber inclusion bodies (HP:0100299)3.14392722
28Right ventricular cardiomyopathy (HP:0011663)3.12586985
29Myokymia (HP:0002411)3.06075775
30Myoglobinuria (HP:0002913)3.03961693
31Gowers sign (HP:0003391)3.01983377
32Acute necrotizing encephalopathy (HP:0006965)3.01543650
33Onion bulb formation (HP:0003383)2.99786435
34Abnormality of glycolysis (HP:0004366)2.89630290
35Increased serum pyruvate (HP:0003542)2.89630290
36Pheochromocytoma (HP:0002666)2.88156725
37Action tremor (HP:0002345)2.86188104
38Bundle branch block (HP:0011710)2.85987943
39Nemaline bodies (HP:0003798)2.78345301
40Abnormal mitochondria in muscle tissue (HP:0008316)2.75719849
41Leukodystrophy (HP:0002415)2.75255777
42Peripheral hypomyelination (HP:0007182)2.71868085
43Palpitations (HP:0001962)2.70675610
44Frequent falls (HP:0002359)2.70286889
45Focal motor seizures (HP:0011153)2.68327845
46Myotonia (HP:0002486)2.68213100
47Abnormality of the corticospinal tract (HP:0002492)2.64827718
48Myopathic facies (HP:0002058)2.64128050
49Obstructive sleep apnea (HP:0002870)2.63938659
50Acute encephalopathy (HP:0006846)2.61503948
51Areflexia of lower limbs (HP:0002522)2.60049565
52Distal arthrogryposis (HP:0005684)2.58107021
53Ventricular arrhythmia (HP:0004308)2.56600774
54* Foot dorsiflexor weakness (HP:0009027)2.56434166
55Cerebral hypomyelination (HP:0006808)2.55573169
56Cerebral inclusion bodies (HP:0100314)2.55568724
57Increased variability in muscle fiber diameter (HP:0003557)2.55441772
58* Abnormality of the foot musculature (HP:0001436)2.53743031
59Neuroendocrine neoplasm (HP:0100634)2.52033071
60Increased connective tissue (HP:0009025)2.47732434
61Hepatocellular necrosis (HP:0001404)2.43447636
62Asymmetric septal hypertrophy (HP:0001670)2.42379566
63Progressive macrocephaly (HP:0004481)2.42265348
64Type 1 muscle fiber predominance (HP:0003803)2.41728642
65Scapular winging (HP:0003691)2.40513033
66Rimmed vacuoles (HP:0003805)2.40131847
67Mitochondrial inheritance (HP:0001427)2.40093356
68Heart block (HP:0012722)2.38722991
69Axonal loss (HP:0003447)2.38384292
70Hepatic necrosis (HP:0002605)2.37355522
71Mildly elevated creatine phosphokinase (HP:0008180)2.36873060
72Muscle stiffness (HP:0003552)2.36054068
73Sensory axonal neuropathy (HP:0003390)2.35716922
74Cerebral hemorrhage (HP:0001342)2.34397916
75Parakeratosis (HP:0001036)2.32102390
76Febrile seizures (HP:0002373)2.30990802
77Abnormality of binocular vision (HP:0011514)2.30054777
78Diplopia (HP:0000651)2.30054777
79Abnormal auditory evoked potentials (HP:0006958)2.28974991
80Diaphragmatic weakness (HP:0009113)2.28644693
81Abnormal eating behavior (HP:0100738)2.28610560
82Insidious onset (HP:0003587)2.27130790
83Termporal pattern (HP:0011008)2.27130790
84Abnormal atrioventricular conduction (HP:0005150)2.24952014
85Abnormality of skeletal muscle fiber size (HP:0012084)2.24076102
86Lower limb amyotrophy (HP:0007210)2.22288793
87Generalized muscle weakness (HP:0003324)2.19221989
88Hypoplasia of the iris (HP:0007676)2.19151420
89Round ear (HP:0100830)2.17230250
90Centrally nucleated skeletal muscle fibers (HP:0003687)2.14862427
91Rhabdomyolysis (HP:0003201)2.13462068
92Atrioventricular block (HP:0001678)2.09994439
93Atonic seizures (HP:0010819)2.08558384
94Segmental peripheral demyelination/remyelination (HP:0003481)2.07819637
95Abnormal EKG (HP:0003115)2.07531719
96Generalized tonic-clonic seizures (HP:0002069)2.06572219
97Left ventricular hypertrophy (HP:0001712)2.05761851
98Increased circulating renin level (HP:0000848)2.05327568
99Ventricular fibrillation (HP:0001663)2.05098320
100Alacrima (HP:0000522)2.05076003
101Stridor (HP:0010307)2.02881798
102Hypoplastic left heart (HP:0004383)2.00528375
103Increased CSF lactate (HP:0002490)1.99904939
104Bulbar palsy (HP:0001283)1.99715113
105Focal seizures (HP:0007359)1.99598158
106Broad metatarsal (HP:0001783)1.98048210
107Cerebral edema (HP:0002181)1.97782885
108* Neck muscle weakness (HP:0000467)1.96165364
109Fetal akinesia sequence (HP:0001989)1.94679648
110Difficulty climbing stairs (HP:0003551)1.93163296
111Large for gestational age (HP:0001520)1.92577600
112Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91294639
113Steppage gait (HP:0003376)1.91071127
114Intention tremor (HP:0002080)1.90930144
115Hypoplastic ischia (HP:0003175)1.89297848
116Sudden cardiac death (HP:0001645)1.88918246
117* Palmoplantar keratoderma (HP:0000982)1.88405942
118Supranuclear gaze palsy (HP:0000605)1.87364948
119Dysmetria (HP:0001310)1.86073262
120Ulnar deviation of the wrist (HP:0003049)1.84401437
121Distal lower limb amyotrophy (HP:0008944)1.83354452
122Ankle clonus (HP:0011448)1.82722672
123Mutism (HP:0002300)1.82467902
124Abnormality of the salivary glands (HP:0010286)1.80990628
125Hypoplastic heart (HP:0001961)1.78421642
126Spinal rigidity (HP:0003306)1.77839576
127Pulmonary artery stenosis (HP:0004415)1.76682727
128Distal lower limb muscle weakness (HP:0009053)1.76635163
129Split foot (HP:0001839)1.73417953
130Turricephaly (HP:0000262)1.72763082
131Lower limb muscle weakness (HP:0007340)1.71778444
132Oligomenorrhea (HP:0000876)1.69647936
133Hemiplegia (HP:0002301)1.69260502
134Shallow orbits (HP:0000586)1.67836855
135Anxiety (HP:0000739)1.64191660
136* Slow progression (HP:0003677)1.63828351
137Sleep apnea (HP:0010535)1.62685184
138Absence seizures (HP:0002121)1.62095859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.22181939
2TTN3.63820151
3OBSCN3.37542135
4OXSR13.20783858
5PHKG23.11391100
6PHKG13.11391100
7EPHB12.96865101
8WNK42.87103817
9NTRK32.76522639
10MYLK2.31896965
11LIMK12.31778640
12MUSK2.29708741
13DMPK2.20856294
14RIPK12.11136522
15NTRK22.03961156
16LMTK21.96302736
17WNK11.94194485
18EPHA41.93438851
19CAMK2D1.90541759
20MAPKAPK51.88469221
21MET1.88080658
22PIK3CA1.83372029
23BCR1.81336085
24ROCK21.77946452
25ARAF1.77387357
26PAK31.68471553
27FGFR21.63605392
28* PKN11.62471191
29LATS21.62311174
30PRKD11.51938308
31MAP3K91.44281243
32TRPM71.42693154
33DAPK21.40833296
34PINK11.39548634
35CAMK2B1.39380381
36PDK31.33932793
37PDK41.33932793
38PDK21.32526814
39PBK1.30742800
40UHMK11.28431031
41BCKDK1.27778666
42CDK191.18579426
43ICK1.17642103
44CAMK2G1.17433085
45MOS1.16026365
46MAP3K131.13901796
47DAPK31.11251940
48SGK4941.08514968
49SGK2231.08514968
50PRPF4B1.05488074
51TIE11.03323299
52ILK1.02151766
53CSNK1A1L1.01290808
54PAK61.00525959
55CSNK1G31.00453405
56CAMK2A0.99810686
57NTRK10.98106847
58MINK10.97279747
59TESK20.96885546
60ROCK10.93998772
61NEK60.91937459
62MAP3K120.91088277
63GRK70.90993646
64STK38L0.88511906
65PRKCE0.85268692
66PNCK0.83746032
67PDGFRA0.83716061
68MST40.82559839
69SGK20.81663215
70MAP2K10.78482505
71STK380.77442648
72GRK50.76467148
73MAPK40.73728585
74MARK20.72837048
75SGK30.71972378
76MAPK100.71546936
77CDC42BPA0.71201578
78CSNK1G10.71154775
79PDPK10.69845318
80CLK10.68529631
81RAF10.68453301
82MAPK120.68383949
83MAPKAPK30.66507491
84MAP2K40.65622060
85PRKACB0.65423243
86CAMK40.64581701
87FGR0.64248169
88TESK10.63932356
89PTK2B0.63861456
90CSNK1G20.62538774
91NME10.62087836
92MAP3K60.61315102
93TRIB30.58941360
94PRKCQ0.58366574
95MAP3K70.56089607
96AKT20.55342798
97PRKAA10.55152321
98KSR10.55005788
99DYRK20.54995981
100PLK20.54912519
101CAMKK10.54515989
102PRKCH0.52920535
103TGFBR20.52404141
104TYRO30.52244874
105RPS6KA30.51035507
106PTK20.50927878
107RET0.47340755
108CDK140.46644072
109STK40.45697446
110MAP3K10.45400157
111DDR20.45347102
112ABL20.44785060
113PRKACA0.44094675
114EPHA30.43667847
115CDK50.43334202
116PRKD30.42134717
117MAPK130.41978913
118EPHB20.40953786
119GSK3A0.38615725
120* PRKG10.38588452
121PRKACG0.38189257
122CDK150.37092687
123PRKAA20.35826792
124CASK0.33027059
125FYN0.32821369
126CSNK1D0.32653754
127MARK10.32463129
128PAK20.31410107
129PDK10.31288895
130CDK180.31260183
131RPS6KA50.31193594
132CDK11A0.30654320
133MAPK70.29457112
134TNIK0.29454872
135PDGFRB0.28562111
136MAPK150.28500611
137STK110.28166621
138PIK3CG0.27664556
139MAP2K20.27348859
140SGK10.27178323
141KSR20.25914851
142CAMK1G0.24406508
143CAMK10.23983045

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.82424091
2Cardiac muscle contraction_Homo sapiens_hsa042603.63552010
3Oxidative phosphorylation_Homo sapiens_hsa001903.63078104
4Parkinsons disease_Homo sapiens_hsa050123.26615658
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.22871219
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.94779106
7Dilated cardiomyopathy_Homo sapiens_hsa054142.83020892
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.71822050
9Alzheimers disease_Homo sapiens_hsa050102.60682445
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53911582
11Propanoate metabolism_Homo sapiens_hsa006402.40391120
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37646116
13Steroid biosynthesis_Homo sapiens_hsa001002.13011991
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04689954
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.95529975
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93313750
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90415917
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90107391
19Huntingtons disease_Homo sapiens_hsa050161.86591757
20Insulin secretion_Homo sapiens_hsa049111.82957286
21Circadian rhythm_Homo sapiens_hsa047101.76510281
22Long-term potentiation_Homo sapiens_hsa047201.75853071
23Ether lipid metabolism_Homo sapiens_hsa005651.72199028
24Butanoate metabolism_Homo sapiens_hsa006501.69237578
25Fatty acid metabolism_Homo sapiens_hsa012121.69135751
26Amphetamine addiction_Homo sapiens_hsa050311.65269792
27Nicotine addiction_Homo sapiens_hsa050331.58102978
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56642542
29Synaptic vesicle cycle_Homo sapiens_hsa047211.47815510
30Fatty acid degradation_Homo sapiens_hsa000711.43803235
31Arginine and proline metabolism_Homo sapiens_hsa003301.34147587
32Prion diseases_Homo sapiens_hsa050201.33906701
33Pyruvate metabolism_Homo sapiens_hsa006201.33426401
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33344929
35Nitrogen metabolism_Homo sapiens_hsa009101.29810527
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29037474
37Tight junction_Homo sapiens_hsa045301.28573158
38Sulfur metabolism_Homo sapiens_hsa009201.26722657
39Carbon metabolism_Homo sapiens_hsa012001.20387684
40Dopaminergic synapse_Homo sapiens_hsa047281.18750662
41Linoleic acid metabolism_Homo sapiens_hsa005911.11504755
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09811477
43Bile secretion_Homo sapiens_hsa049761.09628068
44Axon guidance_Homo sapiens_hsa043601.06766326
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06719237
46GnRH signaling pathway_Homo sapiens_hsa049121.06607227
47Estrogen signaling pathway_Homo sapiens_hsa049151.03541427
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01717507
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97008195
50Phenylalanine metabolism_Homo sapiens_hsa003600.95687820
51ECM-receptor interaction_Homo sapiens_hsa045120.95173368
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93559270
53Vitamin B6 metabolism_Homo sapiens_hsa007500.91552469
54Glucagon signaling pathway_Homo sapiens_hsa049220.91280553
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.90401635
56Renal cell carcinoma_Homo sapiens_hsa052110.88336828
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87662899
58Melanogenesis_Homo sapiens_hsa049160.85352735
59Viral myocarditis_Homo sapiens_hsa054160.85214450
60Insulin signaling pathway_Homo sapiens_hsa049100.85007768
61AMPK signaling pathway_Homo sapiens_hsa041520.83294900
62Histidine metabolism_Homo sapiens_hsa003400.82637231
63Arginine biosynthesis_Homo sapiens_hsa002200.81216853
64Sphingolipid metabolism_Homo sapiens_hsa006000.77278986
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76153278
66Glioma_Homo sapiens_hsa052140.72988510
67* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71763269
68Thyroid hormone synthesis_Homo sapiens_hsa049180.70025760
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68370365
70Protein export_Homo sapiens_hsa030600.68300854
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68032489
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66647773
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66445919
74Focal adhesion_Homo sapiens_hsa045100.65884742
75MAPK signaling pathway_Homo sapiens_hsa040100.62653856
76Gastric acid secretion_Homo sapiens_hsa049710.62128200
77GABAergic synapse_Homo sapiens_hsa047270.61800996
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60614843
79PPAR signaling pathway_Homo sapiens_hsa033200.60064470
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58363520
81Arachidonic acid metabolism_Homo sapiens_hsa005900.58354444
82Peroxisome_Homo sapiens_hsa041460.57079507
83ErbB signaling pathway_Homo sapiens_hsa040120.55147469
84Glutathione metabolism_Homo sapiens_hsa004800.54426907
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53440508
86Ovarian steroidogenesis_Homo sapiens_hsa049130.53421716
87Taste transduction_Homo sapiens_hsa047420.52621364
88Serotonergic synapse_Homo sapiens_hsa047260.52097657
89beta-Alanine metabolism_Homo sapiens_hsa004100.50832561
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50330595
91Rap1 signaling pathway_Homo sapiens_hsa040150.49399093
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49031059
93Glutamatergic synapse_Homo sapiens_hsa047240.48337964
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48127823
95Vibrio cholerae infection_Homo sapiens_hsa051100.47238780
96Calcium signaling pathway_Homo sapiens_hsa040200.47216295
97Circadian entrainment_Homo sapiens_hsa047130.46223852
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46214124
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.45877839
100Folate biosynthesis_Homo sapiens_hsa007900.45865117
101Metabolic pathways_Homo sapiens_hsa011000.44949640
102Renin secretion_Homo sapiens_hsa049240.43282106
103Olfactory transduction_Homo sapiens_hsa047400.43049987
104Oxytocin signaling pathway_Homo sapiens_hsa049210.42910039
105Endocytosis_Homo sapiens_hsa041440.42532828
106Morphine addiction_Homo sapiens_hsa050320.41199325
107VEGF signaling pathway_Homo sapiens_hsa043700.41178287
108cAMP signaling pathway_Homo sapiens_hsa040240.40682762
109Fatty acid biosynthesis_Homo sapiens_hsa000610.40401387
110Adherens junction_Homo sapiens_hsa045200.40090592
111Ras signaling pathway_Homo sapiens_hsa040140.40040759
112Pancreatic secretion_Homo sapiens_hsa049720.39859761
113Biosynthesis of amino acids_Homo sapiens_hsa012300.39783370
114Gap junction_Homo sapiens_hsa045400.39146822
115Insulin resistance_Homo sapiens_hsa049310.38258046
116Collecting duct acid secretion_Homo sapiens_hsa049660.38199678
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.37968023
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.37784087
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.36967684
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36492951
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36304159
122Choline metabolism in cancer_Homo sapiens_hsa052310.35712127
123Glycerolipid metabolism_Homo sapiens_hsa005610.35419998
124Salivary secretion_Homo sapiens_hsa049700.35395933
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34426483
126Tyrosine metabolism_Homo sapiens_hsa003500.33574628
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.31015618
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30779318
129Dorso-ventral axis formation_Homo sapiens_hsa043200.29719529
130Hedgehog signaling pathway_Homo sapiens_hsa043400.28979848
131Long-term depression_Homo sapiens_hsa047300.28954603
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28765289
133Amoebiasis_Homo sapiens_hsa051460.28495657
134Cholinergic synapse_Homo sapiens_hsa047250.27987748
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.26674330
136Cocaine addiction_Homo sapiens_hsa050300.26298658
137Tryptophan metabolism_Homo sapiens_hsa003800.25244831
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24519604
139Mineral absorption_Homo sapiens_hsa049780.23036177
140Lysosome_Homo sapiens_hsa041420.22564061
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19568748

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