CRYBA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of the vertebrate eye, which function to maintain the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also defined as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group but absent in the acidic group). Beta-crystallins form aggregates of different sizes and are able to form homodimers through self-association or heterodimers with other beta-crystallins. This gene is a beta acidic group member. Three alternatively spliced transcript variants encoding identical proteins have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lens morphogenesis in camera-type eye (GO:0002089)8.25226557
2visual perception (GO:0007601)8.16632592
3sensory perception of light stimulus (GO:0050953)8.13969574
4response to muscle activity (GO:0014850)7.60175778
5protein refolding (GO:0042026)6.72821823
6camera-type eye development (GO:0043010)6.58672472
7histone H3-K9 demethylation (GO:0033169)6.21997152
8cytolysis (GO:0019835)6.19614247
9muscle cell cellular homeostasis (GO:0046716)6.14102557
10regulation of protein sumoylation (GO:0033233)6.08504064
11eye development (GO:0001654)5.76466213
12Golgi transport vesicle coating (GO:0048200)5.76049252
13COPI coating of Golgi vesicle (GO:0048205)5.76049252
14nodal signaling pathway (GO:0038092)5.43832282
15bile acid and bile salt transport (GO:0015721)5.19533589
16positive regulation of gluconeogenesis (GO:0045722)5.16504990
17negative regulation of execution phase of apoptosis (GO:1900118)5.00064531
18sensory organ development (GO:0007423)4.61637397
19myofibril assembly (GO:0030239)4.53315826
20cellular response to osmotic stress (GO:0071470)4.49847289
21positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)4.17001488
22COPII vesicle coating (GO:0048208)4.16256331
23auditory receptor cell differentiation (GO:0042491)4.10363328
24nephron epithelium morphogenesis (GO:0072088)4.04324310
25nephron tubule morphogenesis (GO:0072078)4.04324310
26sensory perception (GO:0007600)4.03408637
27inositol phosphate catabolic process (GO:0071545)4.01935621
28negative regulation of homotypic cell-cell adhesion (GO:0034111)3.99411847
29respiratory chain complex IV assembly (GO:0008535)3.98443248
30cellular ketone body metabolic process (GO:0046950)3.95781052
31L-alpha-amino acid transmembrane transport (GO:1902475)3.93493164
32regulation of autophagic vacuole assembly (GO:2000785)3.93029735
33response to salt stress (GO:0009651)3.92803645
34inositol phosphate dephosphorylation (GO:0046855)3.90326651
35phosphorylated carbohydrate dephosphorylation (GO:0046838)3.90326651
36chemosensory behavior (GO:0007635)3.90125938
37negative regulation of JUN kinase activity (GO:0043508)3.85215050
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.84843598
39insulin-like growth factor receptor signaling pathway (GO:0048009)3.83228048
40positive regulation of calcium ion import (GO:0090280)3.81382203
41energy homeostasis (GO:0097009)3.75856494
42cytochrome complex assembly (GO:0017004)3.74060292
43endocrine pancreas development (GO:0031018)3.70871720
44positive regulation of histone H3-K4 methylation (GO:0051571)3.68018154
45L-phenylalanine metabolic process (GO:0006558)3.66881778
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.66881778
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.65910632
48response to nitrosative stress (GO:0051409)3.62468525
49peptide hormone processing (GO:0016486)3.61550602
50L-phenylalanine catabolic process (GO:0006559)3.57512936
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.57512936
52cellular response to vitamin D (GO:0071305)3.51741766
53retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.51280565
54protein retention in ER lumen (GO:0006621)3.49991473
55ketone body metabolic process (GO:1902224)3.47723363
56detection of calcium ion (GO:0005513)3.47028762
57sarcomere organization (GO:0045214)3.41880229
58renal tubule morphogenesis (GO:0061333)3.40598324
59regulation of vacuole organization (GO:0044088)3.39886455
60positive regulation of insulin secretion (GO:0032024)3.38475643
61regulation of extracellular matrix disassembly (GO:0010715)3.38130433
62glandular epithelial cell differentiation (GO:0002067)3.34217885
63somite rostral/caudal axis specification (GO:0032525)3.33904721
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.31512685
65water-soluble vitamin biosynthetic process (GO:0042364)3.29521714
66positive regulation of glycolytic process (GO:0045821)3.27978957
67nitric oxide biosynthetic process (GO:0006809)3.27312515
68negative regulation of cAMP-mediated signaling (GO:0043951)3.21232971
69positive regulation of neurotransmitter transport (GO:0051590)3.20944048
70positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.20312813
71serotonin metabolic process (GO:0042428)3.17145654
72pteridine-containing compound biosynthetic process (GO:0042559)3.14378266
73positive regulation of macroautophagy (GO:0016239)3.13657981
74brain morphogenesis (GO:0048854)3.13052728
75glycerophospholipid catabolic process (GO:0046475)3.10493244
76water transport (GO:0006833)3.10339718
77polyol catabolic process (GO:0046174)3.09913482
78cysteine metabolic process (GO:0006534)3.08176541
79regulation of neurotransmitter uptake (GO:0051580)3.06479590
80toxin metabolic process (GO:0009404)3.03750708
81type B pancreatic cell development (GO:0003323)3.01307216
82* lens development in camera-type eye (GO:0002088)27.6368088
83lens fiber cell development (GO:0070307)20.2754893
84positive regulation of response to extracellular stimulus (GO:0032106)2.98658489
85positive regulation of response to nutrient levels (GO:0032109)2.98658489
86negative regulation of hormone biosynthetic process (GO:0032353)2.97548261
87regulation of hexokinase activity (GO:1903299)2.97495230
88regulation of glucokinase activity (GO:0033131)2.97495230
89preassembly of GPI anchor in ER membrane (GO:0016254)2.96716137
90negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96260594
91vesicle coating (GO:0006901)2.93069530
92insulin secretion (GO:0030073)2.91650885
93primary amino compound metabolic process (GO:1901160)2.90208509
94glutathione derivative biosynthetic process (GO:1901687)2.88348344
95glutathione derivative metabolic process (GO:1901685)2.88348344
96regulation of insulin secretion (GO:0050796)2.88069385
97regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.87183830
98regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.87183830
99toxin transport (GO:1901998)2.86851775
100regulation of type B pancreatic cell apoptotic process (GO:2000674)2.85447593
101cellular sodium ion homeostasis (GO:0006883)2.85148872
102inositol phosphate-mediated signaling (GO:0048016)2.85059025
103beta-amyloid metabolic process (GO:0050435)2.84859880
104retinol metabolic process (GO:0042572)2.84187172
105regulation of myoblast differentiation (GO:0045661)2.82838057
106dentate gyrus development (GO:0021542)2.82101817
107regulation of execution phase of apoptosis (GO:1900117)2.81573061
108xenobiotic catabolic process (GO:0042178)2.80553162
109organic cation transport (GO:0015695)2.79946215
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79182243
111sequestering of metal ion (GO:0051238)2.78401616
112protein autoprocessing (GO:0016540)2.76014997
113axoneme assembly (GO:0035082)2.75864681
114signal peptide processing (GO:0006465)2.75842990
115dopaminergic neuron differentiation (GO:0071542)2.75487360
116positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.75199073
117C-terminal protein lipidation (GO:0006501)2.72782357
118positive regulation of peptide hormone secretion (GO:0090277)2.72396558
119signal transduction involved in regulation of gene expression (GO:0023019)2.71315790
120zinc ion homeostasis (GO:0055069)2.69074403
121magnesium ion transport (GO:0015693)2.67877591
122regulation of platelet aggregation (GO:0090330)2.67842100
123peptide transport (GO:0015833)2.66677877
124snRNA transcription (GO:0009301)2.66671039
125regulation of oxidative phosphorylation (GO:0002082)2.66383686
126fluid transport (GO:0042044)2.64642062
127positive regulation of meiosis (GO:0045836)2.64490555
128response to dietary excess (GO:0002021)2.63993164
129positive regulation of peptide secretion (GO:0002793)2.63777814
130response to pheromone (GO:0019236)2.63540751
131regulation of peptide hormone secretion (GO:0090276)2.62613879
132protein homotrimerization (GO:0070207)2.62123567
133activin receptor signaling pathway (GO:0032924)2.60845177
134lactate metabolic process (GO:0006089)2.59588028
135regulation of peptide secretion (GO:0002791)2.57846189
136protein maturation by protein folding (GO:0022417)2.57586273
137macroautophagy (GO:0016236)2.53741722
138neuron fate specification (GO:0048665)2.51011047
139positive regulation of vesicle fusion (GO:0031340)2.47887841
140activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.44065520
141lung epithelium development (GO:0060428)2.42727557
142positive regulation of calcium ion transport into cytosol (GO:0010524)2.41350340
143negative regulation of insulin secretion (GO:0046676)2.39330960
144dorsal/ventral axis specification (GO:0009950)2.32923187
145negative regulation of catecholamine secretion (GO:0033604)2.32606471
146cellular response to vitamin (GO:0071295)2.31274791
147peptide hormone secretion (GO:0030072)2.30970416
148exocrine pancreas development (GO:0031017)2.30337318
149regulation of hormone secretion (GO:0046883)2.29679171
150regulation of Rac protein signal transduction (GO:0035020)2.28755446
151regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.28482052
152regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.28114043
153negative regulation of cell size (GO:0045792)2.27360569
154positive regulation of nuclease activity (GO:0032075)2.26772855
155cellular response to glucagon stimulus (GO:0071377)2.24881724
156astrocyte differentiation (GO:0048708)2.22109242
157peptide secretion (GO:0002790)2.21688324
158glycine transport (GO:0015816)2.21426624
159cellular response to prostaglandin stimulus (GO:0071379)2.19946926
160negative regulation of norepinephrine secretion (GO:0010700)2.19637726
161response to activity (GO:0014823)2.19044590
162nitric oxide mediated signal transduction (GO:0007263)2.18070284
163intermediate filament cytoskeleton organization (GO:0045104)2.17767674
164histone lysine demethylation (GO:0070076)2.15979764
165cellular response to calcium ion (GO:0071277)2.15025784
166epithelial cell fate commitment (GO:0072148)2.15011518
167regulation of skeletal muscle fiber development (GO:0048742)2.14642136
168positive regulation of hormone secretion (GO:0046887)2.14485356
169cornea development in camera-type eye (GO:0061303)2.14400367
170negative regulation of osteoblast proliferation (GO:0033689)2.13792208
171regulation of non-canonical Wnt signaling pathway (GO:2000050)2.13081848
172intermediate filament-based process (GO:0045103)2.11975113
173epithelial cell development (GO:0002064)2.11491632
174lens fiber cell differentiation (GO:0070306)16.5105503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse9.53406168
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.66117875
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.60059612
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30611955
5PCGF2_27294783_Chip-Seq_NPCs_Mouse2.87707724
6GBX2_23144817_ChIP-Seq_PC3_Human2.65866142
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53820548
8VDR_22108803_ChIP-Seq_LS180_Human2.42338995
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.34324398
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23147223
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22419492
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.16481104
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13064606
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09789291
15HTT_18923047_ChIP-ChIP_STHdh_Human2.04128028
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.87023164
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.81217608
18NFE2_27457419_Chip-Seq_LIVER_Mouse1.80297627
19* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80187012
20IGF1R_20145208_ChIP-Seq_DFB_Human1.79244650
21EGR1_19032775_ChIP-ChIP_M12_Human1.79050973
22GATA1_22025678_ChIP-Seq_K562_Human1.75068084
23BCAT_22108803_ChIP-Seq_LS180_Human1.74141829
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73528739
25* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.65019774
26FUS_26573619_Chip-Seq_HEK293_Human1.64065870
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63232352
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62418036
29NR3C1_23031785_ChIP-Seq_PC12_Mouse1.62149190
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61372462
31SMAD4_21799915_ChIP-Seq_A2780_Human1.57680922
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55283342
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54853757
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51936404
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.50742779
36* EZH2_27294783_Chip-Seq_ESCs_Mouse1.50148038
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48566084
38OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47730715
39P300_19829295_ChIP-Seq_ESCs_Human1.46557121
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45673148
41SOX2_22085726_ChIP-Seq_NPCs_Mouse1.43091238
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42467969
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.41682919
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40753072
45ZNF274_21170338_ChIP-Seq_K562_Hela1.40608190
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40139200
47* REST_21632747_ChIP-Seq_MESCs_Mouse1.39884900
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39638978
49* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39172125
50TAF15_26573619_Chip-Seq_HEK293_Human1.37822207
51AR_25329375_ChIP-Seq_VCAP_Human1.37186514
52* CTCF_18555785_Chip-Seq_ESCs_Mouse1.36944118
53STAT3_23295773_ChIP-Seq_U87_Human1.35879172
54EZH2_22144423_ChIP-Seq_EOC_Human1.35149964
55* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.34377407
56TP53_22573176_ChIP-Seq_HFKS_Human1.33687940
57* RNF2_27304074_Chip-Seq_ESCs_Mouse1.32857629
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32674651
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32207152
60SOX2_18555785_Chip-Seq_ESCs_Mouse1.31194702
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.31150040
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31150040
63* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30503350
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29980287
65* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.28923478
66* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27325313
67* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26622134
68* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26234536
69* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25646339
70* EZH2_27294783_Chip-Seq_NPCs_Mouse1.24696642
71KLF4_18555785_Chip-Seq_ESCs_Mouse1.23555634
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23220964
73FOXA1_25552417_ChIP-Seq_VCAP_Human1.22877651
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22855112
75CTCF_27219007_Chip-Seq_Bcells_Human1.21997003
76* REST_18959480_ChIP-ChIP_MESCs_Mouse1.21639915
77CDX2_22108803_ChIP-Seq_LS180_Human1.20811920
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20716082
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20467578
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20078575
81* GATA3_24758297_ChIP-Seq_MCF-7_Human1.20031499
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19891440
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18570787
84* CBX2_27304074_Chip-Seq_ESCs_Mouse1.18284686
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.17456442
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.17355428
87* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16753760
88* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16753760
89AR_20517297_ChIP-Seq_VCAP_Human1.16691915
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.15589346
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15443649
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14407343
93CBP_20019798_ChIP-Seq_JUKART_Human1.14407343
94* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12694719
95ER_23166858_ChIP-Seq_MCF-7_Human1.12492146
96* PU1_27457419_Chip-Seq_LIVER_Mouse1.12229355
97* P53_22387025_ChIP-Seq_ESCs_Mouse1.11907256
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.11893788
99SMAD3_21741376_ChIP-Seq_ESCs_Human1.11281477
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09195243
101* EZH2_27304074_Chip-Seq_ESCs_Mouse1.08613275
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08533407
103* NANOG_16153702_ChIP-ChIP_HESCs_Human1.07781044
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07285051
105SOX2_19829295_ChIP-Seq_ESCs_Human1.06148685
106NANOG_19829295_ChIP-Seq_ESCs_Human1.06148685
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06055293
108* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04849453
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04442275
110TCF4_22108803_ChIP-Seq_LS180_Human1.04341871
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02166124
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02105358
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01295350
114P300_18555785_Chip-Seq_ESCs_Mouse1.00807313
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00259890
116RUNX2_22187159_ChIP-Seq_PCA_Human0.99337705
117FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98256582
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97683851
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.97239099
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96334362
121EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95915825
122TAL1_26923725_Chip-Seq_HPCs_Mouse0.95800765
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95659743
124MYC_19829295_ChIP-Seq_ESCs_Human0.95040598
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94486874
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.94095298
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93934240
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.92984234
129EWS_26573619_Chip-Seq_HEK293_Human0.92075330
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92036089
131GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91937777
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.91789927
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90692633
134* CRX_20693478_ChIP-Seq_RETINA_Mouse0.90386402
135TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89479597
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.89306859
137* EED_16625203_ChIP-ChIP_MESCs_Mouse0.86017010
138* ZFX_18555785_Chip-Seq_ESCs_Mouse0.85877411
139* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85086935
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84793499
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84770469
142HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82908477
143* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82567641
144* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82295261
145TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82024144
146P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80844006
147* FOXA2_19822575_ChIP-Seq_HepG2_Human0.80511556
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79436664
149CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79070625
150TDRD3_21172665_ChIP-Seq_MCF-7_Human0.78758584
151JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78514765
152PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.78218849
153GATA2_21666600_ChIP-Seq_HMVEC_Human0.77415586
154JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77312055
155TCF4_23295773_ChIP-Seq_U87_Human0.77153899
156PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.74731235
157DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74373353
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74277090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005193_abnormal_anterior_eye7.31690097
2MP0005253_abnormal_eye_physiology4.98996192
3MP0003941_abnormal_skin_development3.73311993
4MP0001286_abnormal_eye_development3.02567864
5MP0005391_vision/eye_phenotype2.88186343
6MP0000749_muscle_degeneration2.86137901
7MP0002092_abnormal_eye_morphology2.80958306
8MP0005197_abnormal_uvea_morphology2.74754495
9MP0010234_abnormal_vibrissa_follicle2.73248899
10MP0002638_abnormal_pupillary_reflex2.50851625
11MP0000013_abnormal_adipose_tissue2.46016733
12MP0008877_abnormal_DNA_methylation2.30350577
13MP0002090_abnormal_vision2.11118176
14MP0004019_abnormal_vitamin_homeostasis2.05224195
15MP0002697_abnormal_eye_size11.8445349
16MP0005379_endocrine/exocrine_gland_phen1.93634127
17MP0002254_reproductive_system_inflammat1.89839961
18MP0002877_abnormal_melanocyte_morpholog1.88978602
19MP0003195_calcinosis1.87007703
20MP0005332_abnormal_amino_acid1.83503492
21MP0010329_abnormal_lipoprotein_level1.80877914
22MP0002909_abnormal_adrenal_gland1.79062215
23MP0006072_abnormal_retinal_apoptosis1.70676274
24MP0001944_abnormal_pancreas_morphology1.66692270
25MP0003183_abnormal_peptide_metabolism1.65820240
26MP0003122_maternal_imprinting1.64444784
27MP0009046_muscle_twitch1.63269521
28MP0004043_abnormal_pH_regulation1.58347984
29MP0003787_abnormal_imprinting1.50728392
30MP0003172_abnormal_lysosome_physiology1.47772146
31MP0005365_abnormal_bile_salt1.47692454
32MP0002822_catalepsy1.47024546
33MP0002693_abnormal_pancreas_physiology1.45787900
34MP0005551_abnormal_eye_electrophysiolog1.45274638
35MP0000678_abnormal_parathyroid_gland1.44731055
36MP0001346_abnormal_lacrimal_gland1.44722303
37MP0009780_abnormal_chondrocyte_physiolo1.42955018
38MP0004133_heterotaxia1.40243234
39MP0002837_dystrophic_cardiac_calcinosis1.39279929
40MP0002108_abnormal_muscle_morphology1.34045931
41MP0002163_abnormal_gland_morphology1.33820383
42MP0005645_abnormal_hypothalamus_physiol1.29684941
43MP0006292_abnormal_olfactory_placode1.26085150
44MP0002735_abnormal_chemical_nociception1.25541001
45MP0000427_abnormal_hair_cycle1.24224149
46MP0010386_abnormal_urinary_bladder1.24080401
47MP0009745_abnormal_behavioral_response1.22826092
48MP0005220_abnormal_exocrine_pancreas1.22212041
49MP0005257_abnormal_intraocular_pressure1.20355284
50MP0003283_abnormal_digestive_organ1.18993982
51MP0001299_abnormal_eye_distance/1.18776468
52MP0002269_muscular_atrophy1.18552175
53MP0001501_abnormal_sleep_pattern1.16524819
54MP0001502_abnormal_circadian_rhythm1.15112603
55MP0005386_behavior/neurological_phenoty1.13977360
56MP0004924_abnormal_behavior1.13977360
57MP0002009_preneoplasia1.13421127
58MP0003123_paternal_imprinting1.10894874
59MP0005248_abnormal_Harderian_gland1.10403495
60MP0003186_abnormal_redox_activity1.08319748
61MP0003011_delayed_dark_adaptation1.05471046
62MP0005195_abnormal_posterior_eye1.05204010
63MP0000003_abnormal_adipose_tissue1.03384301
64MP0003959_abnormal_lean_body1.03198254
65MP0003137_abnormal_impulse_conducting1.03126353
66MP0010678_abnormal_skin_adnexa1.01976786
67MP0009384_cardiac_valve_regurgitation1.00104547
68MP0003633_abnormal_nervous_system0.99842874
69MP0000639_abnormal_adrenal_gland0.97194450
70MP0004270_analgesia0.97192817
71MP0002734_abnormal_mechanical_nocicepti0.96904677
72MP0002733_abnormal_thermal_nociception0.94057062
73MP0001765_abnormal_ion_homeostasis0.93319681
74MP0001529_abnormal_vocalization0.91998858
75MP0004272_abnormal_basement_membrane0.91913310
76MP0004215_abnormal_myocardial_fiber0.90726750
77MP0002118_abnormal_lipid_homeostasis0.89654082
78MP0002064_seizures0.89275526
79MP0002938_white_spotting0.88455876
80MP0000566_synostosis0.88106208
81MP0005330_cardiomyopathy0.86751133
82MP0002078_abnormal_glucose_homeostasis0.86469266
83MP0005084_abnormal_gallbladder_morpholo0.86248637
84MP0005075_abnormal_melanosome_morpholog0.84262556
85MP0002063_abnormal_learning/memory/cond0.82011926
86MP0002139_abnormal_hepatobiliary_system0.79273618
87MP0010368_abnormal_lymphatic_system0.78540984
88MP0004147_increased_porphyrin_level0.78367833
89MP0002653_abnormal_ependyma_morphology0.74191158
90MP0002177_abnormal_outer_ear0.73548587
91MP0004085_abnormal_heartbeat0.72971623
92MP0001666_abnormal_nutrient_absorption0.72923959
93MP0006036_abnormal_mitochondrial_physio0.72889936
94MP0002069_abnormal_eating/drinking_beha0.72762782
95MP0008872_abnormal_physiological_respon0.69851282
96MP0005452_abnormal_adipose_tissue0.69209200
97MP0000470_abnormal_stomach_morphology0.68412762
98MP0000049_abnormal_middle_ear0.67843117
99MP0005174_abnormal_tail_pigmentation0.66890920
100MP0003786_premature_aging0.66693461
101MP0005535_abnormal_body_temperature0.66578852
102MP0003121_genomic_imprinting0.65707509
103MP0004233_abnormal_muscle_weight0.65088070
104MP0002751_abnormal_autonomic_nervous0.64633551
105MP0005646_abnormal_pituitary_gland0.63023577
106MP0002166_altered_tumor_susceptibility0.62885751
107MP0009642_abnormal_blood_homeostasis0.62719837
108MP0003119_abnormal_digestive_system0.61240175
109MP0003252_abnormal_bile_duct0.59448323
110MP0002184_abnormal_innervation0.59140841
111MP0002928_abnormal_bile_duct0.57692456
112MP0005187_abnormal_penis_morphology0.57557300
113MP0005636_abnormal_mineral_homeostasis0.57444760
114MP0001905_abnormal_dopamine_level0.56828825
115MP0001324_abnormal_eye_pigmentation0.56425457
116MP0001340_abnormal_eyelid_morphology0.56329639
117MP0006276_abnormal_autonomic_nervous0.55619921
118MP0002138_abnormal_hepatobiliary_system0.54653489
119MP0002272_abnormal_nervous_system0.50856598
120MP0003953_abnormal_hormone_level0.50457113
121MP0001970_abnormal_pain_threshold0.50195336
122MP0001986_abnormal_taste_sensitivity0.49137769
123MP0002876_abnormal_thyroid_physiology0.48856340
124MP0001188_hyperpigmentation0.48460591
125MP0002557_abnormal_social/conspecific_i0.48194567
126MP0003879_abnormal_hair_cell0.47785167
127MP0004264_abnormal_extraembryonic_tissu0.46863996
128MP0005319_abnormal_enzyme/_coenzyme0.46572091
129MP0005369_muscle_phenotype0.46097233
130MP0003635_abnormal_synaptic_transmissio0.46044485
131MP0002572_abnormal_emotion/affect_behav0.45404331
132MP0000955_abnormal_spinal_cord0.44799143
133MP0004885_abnormal_endolymph0.44433199
134MP0000230_abnormal_systemic_arterial0.42786568
135MP0008961_abnormal_basal_metabolism0.41723963
136MP0001661_extended_life_span0.40815235
137MP0005448_abnormal_energy_balance0.40319925
138MP0001756_abnormal_urination0.39681030
139MP0001968_abnormal_touch/_nociception0.39552391
140MP0000631_abnormal_neuroendocrine_gland0.39284727
141MP0009643_abnormal_urine_homeostasis0.37342632
142MP0002896_abnormal_bone_mineralization0.37193449
143MP0002229_neurodegeneration0.36692715

Predicted human phenotypes

RankGene SetZ-score
1Corneal dystrophy (HP:0001131)6.91237636
2* Congenital cataract (HP:0000519)6.82640438
3Congenital malformation of the right heart (HP:0011723)6.63224072
4Double outlet right ventricle (HP:0001719)6.63224072
5Amblyopia (HP:0000646)6.58758312
6Increased circulating renin level (HP:0000848)6.20797417
7Anterior segment dysgenesis (HP:0007700)5.54508333
8Hyperkalemia (HP:0002153)4.77881097
9Hyperactive renin-angiotensin system (HP:0000841)4.36734804
10Polar cataract (HP:0010696)4.11941637
11Microcornea (HP:0000482)3.63756895
12Clumsiness (HP:0002312)3.56328265
13Hematochezia (HP:0002573)3.19507223
14Hypoalbuminemia (HP:0003073)3.11983229
15Abnormal albumin level (HP:0012116)3.11983229
16Nuclear cataract (HP:0100018)26.2667849
17Zonular cataract (HP:0010920)23.6841396
18Abnormality of renin-angiotensin system (HP:0000847)2.98850352
19Abnormality of vitamin B metabolism (HP:0004340)2.91863472
20Iris coloboma (HP:0000612)2.91270683
21Abnormality of potassium homeostasis (HP:0011042)2.84414581
22Hyperaldosteronism (HP:0000859)2.74609540
23Increased CSF protein (HP:0002922)2.70786252
24Opacification of the corneal stroma (HP:0007759)2.64062392
25Congenital primary aphakia (HP:0007707)2.57955653
26Ketosis (HP:0001946)2.53875194
27Eosinophilia (HP:0001880)2.53264023
28Abnormality of abdominal situs (HP:0011620)2.53259757
29Abdominal situs inversus (HP:0003363)2.53259757
30Enlarged penis (HP:0000040)2.50633992
31Toxemia of pregnancy (HP:0100603)2.49881468
32Abnormality of vitamin metabolism (HP:0100508)2.41459525
33Vascular calcification (HP:0004934)2.38359319
34Mesangial abnormality (HP:0001966)2.37736823
35Sclerocornea (HP:0000647)2.34539663
36Hemiparesis (HP:0001269)2.32383925
37Gastrointestinal atresia (HP:0002589)2.31354053
38Ventricular fibrillation (HP:0001663)2.27543172
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27323315
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27323315
41Postural tremor (HP:0002174)2.25085809
42Progressive neurologic deterioration (HP:0002344)2.24789124
43Aplasia/Hypoplasia of the lens (HP:0008063)2.23363842
44Proximal tubulopathy (HP:0000114)2.21567822
45Abnormality of the anterior chamber (HP:0000593)2.18545457
46Vacuolated lymphocytes (HP:0001922)2.18400381
47Hyponatremia (HP:0002902)2.17308086
48Congenital sensorineural hearing impairment (HP:0008527)2.15679040
49Abnormal sex determination (HP:0012244)2.14177170
50Sex reversal (HP:0012245)2.14177170
51Popliteal pterygium (HP:0009756)2.14004960
52Oligodactyly (hands) (HP:0001180)2.13558231
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12261712
54Aqueductal stenosis (HP:0002410)2.12209728
55Abnormality of polysaccharide metabolism (HP:0011012)2.12129664
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12129664
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12129664
58Truncus arteriosus (HP:0001660)2.09497627
59Abnormality of chloride homeostasis (HP:0011422)2.09230999
60Hyperinsulinemic hypoglycemia (HP:0000825)2.08963275
61Unilateral renal agenesis (HP:0000122)2.07790506
62Aplasia/Hypoplasia of the macula (HP:0008059)2.07399129
63Methylmalonic acidemia (HP:0002912)2.03640557
64Testicular atrophy (HP:0000029)2.03319561
65Posterior subcapsular cataract (HP:0007787)2.02470335
66Muscular hypotonia of the trunk (HP:0008936)2.02119090
67Granulocytopenia (HP:0001913)2.02012079
68Cardiovascular calcification (HP:0011915)2.01111578
69Conjunctival hamartoma (HP:0100780)2.00312928
70Renal cortical cysts (HP:0000803)1.98637187
71Syncope (HP:0001279)1.97911399
72Glycosuria (HP:0003076)1.97215592
73Abnormality of urine glucose concentration (HP:0011016)1.97215592
74Abnormal biliary tract morphology (HP:0012440)1.97166635
75Anxiety (HP:0000739)1.96629811
76Aplasia/Hypoplasia affecting the retina (HP:0008061)1.95698277
77J-shaped sella turcica (HP:0002680)1.95532310
78Proximal amyotrophy (HP:0007126)1.95055817
79Hypokinesia (HP:0002375)1.94754628
80Mucopolysacchariduria (HP:0008155)1.94487094
81Urinary glycosaminoglycan excretion (HP:0003541)1.94487094
82Abnormality of the renal cortex (HP:0011035)1.90252061
83Neuroendocrine neoplasm (HP:0100634)1.90061479
84Testicular neoplasm (HP:0010788)1.89657615
85Hypoglycemic seizures (HP:0002173)1.87077470
86Orthostatic hypotension (HP:0001278)1.86303442
87Abnormality of renal resorption (HP:0011038)1.85463837
88Glucose intolerance (HP:0000833)1.83456878
89Progressive macrocephaly (HP:0004481)1.82923066
90Palpitations (HP:0001962)1.82507918
91Adrenal overactivity (HP:0002717)1.79833974
92Gaze-evoked nystagmus (HP:0000640)1.78953638
93Scapular winging (HP:0003691)1.77022471
94Poor suck (HP:0002033)1.76974942
95Hypoglycemic coma (HP:0001325)1.71989430
96Symptomatic seizures (HP:0011145)1.66826270
97Abnormality of eosinophils (HP:0001879)1.64921721
98Abnormality of calcium-phosphate metabolism (HP:0100530)1.55770126
99Abnormality of the labia majora (HP:0012881)1.53650775
100Fetal akinesia sequence (HP:0001989)1.40160776
101Neonatal respiratory distress (HP:0002643)1.39072273
102Akinesia (HP:0002304)1.37631814
103Hyperglycemia (HP:0003074)1.32153244
104Aplasia of the musculature (HP:0100854)1.28452402
105Abnormal pancreas size (HP:0012094)1.27453284
106Abnormality of the pancreatic islet cells (HP:0006476)1.24731180
107Abnormality of endocrine pancreas physiology (HP:0012093)1.24731180
108Difficulty walking (HP:0002355)1.24139089
109Pancreatic islet-cell hyperplasia (HP:0004510)1.23416363
110Late onset (HP:0003584)1.14851694
111Large for gestational age (HP:0001520)1.14490329
112Agitation (HP:0000713)1.14008713
113Hyperparathyroidism (HP:0000843)1.10462246
114Ketoacidosis (HP:0001993)1.10254860
115Neoplasm of the heart (HP:0100544)1.09707147
116Hypoplastic nipples (HP:0002557)1.09679475
117Long clavicles (HP:0000890)1.09508280
118Rib fusion (HP:0000902)1.07288671
119Severe visual impairment (HP:0001141)1.03093616
120Amniotic constriction ring (HP:0009775)1.02824670
121Abnormality of placental membranes (HP:0011409)1.02824670
122Aplasia/hypoplasia of the uterus (HP:0008684)1.02663251
123Symphalangism affecting the phalanges of the hand (HP:0009773)0.97657164
124Abnormality of the shoulder girdle musculature (HP:0001435)0.97330330
125Hypoplasia of the fovea (HP:0007750)0.96714722
126Aplasia/Hypoplasia of the fovea (HP:0008060)0.96714722
127Atelectasis (HP:0100750)0.96256299
128Hyperphosphatemia (HP:0002905)0.94757800
129Decreased circulating renin level (HP:0003351)0.94220036
130Vertebral clefting (HP:0008428)0.93348274
131Retinal atrophy (HP:0001105)0.93278696
132Hypothermia (HP:0002045)0.93104304
133Leukocytosis (HP:0001974)0.92294782
134Subcapsular cataract (HP:0000523)0.90871790
135Absent rod-and cone-mediated responses on ERG (HP:0007688)0.89072878
136Limb hypertonia (HP:0002509)0.88377612
137Chorioretinal coloboma (HP:0000567)0.87447059
138Fused cervical vertebrae (HP:0002949)0.86686255
139Abnormality of aromatic amino acid family metabolism (HP:0004338)0.85835977
140Intestinal atresia (HP:0011100)0.85464992
141Hepatoblastoma (HP:0002884)0.84229599
142Enlarged kidneys (HP:0000105)0.83817907
143Abnormality of the fovea (HP:0000493)0.83659104
144Abnormal rod and cone electroretinograms (HP:0008323)0.83520194
145Insulin-resistant diabetes mellitus (HP:0000831)0.83069530
146Congenital glaucoma (HP:0001087)0.80512038
147Skin nodule (HP:0200036)0.79471512
148Hyperthyroidism (HP:0000836)0.78513060
149Exostoses (HP:0100777)0.76486502
150Pterygium (HP:0001059)0.76166927
151Hypokalemia (HP:0002900)0.75112288
152Abnormality of the labia (HP:0000058)0.73708516
153Broad nasal tip (HP:0000455)0.73303352
154Menstrual irregularities (HP:0000858)0.72924066
155EEG with generalized epileptiform discharges (HP:0011198)0.72323991
156Restlessness (HP:0000711)0.71746758
157Osteomalacia (HP:0002749)0.71608032
158Hypsarrhythmia (HP:0002521)0.71456163
159Pheochromocytoma (HP:0002666)0.71424587
160Epileptiform EEG discharges (HP:0011182)0.69747322
161Dysautonomia (HP:0002459)0.69516826
162Macroorchidism (HP:0000053)0.69261926
163Generalized aminoaciduria (HP:0002909)0.68673073
164Hypoplasia of the uterus (HP:0000013)0.68566863
165Hypotension (HP:0002615)0.67396123
166Prominent metopic ridge (HP:0005487)0.65913020
167Hypercortisolism (HP:0001578)0.65673155
168Thin ribs (HP:0000883)0.64740853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.72256058
2MAP2K65.33375195
3WNK35.01015586
4WNK44.61871585
5INSRR4.35549635
6PHKG13.08415810
7PHKG23.08415810
8FLT33.01324754
9NTRK12.65379795
10PIK3CG2.44504697
11NLK2.34874568
12GRK12.34320827
13BLK2.31237633
14IRAK42.12293142
15ADRBK22.11973002
16FGFR22.04633152
17HIPK21.98899325
18PRKG11.97383807
19PASK1.96423316
20SIK11.73001494
21TNIK1.72471183
22MAP3K91.70744832
23MAP4K21.67077805
24* SGK11.64968020
25UHMK11.63656840
26WNK11.63239488
27TRPM71.62714718
28FGFR31.51078626
29NTRK31.46939966
30MET1.45762024
31TAOK11.40274061
32STK391.38770284
33MKNK21.38137257
34STK31.35426372
35PRKD31.33658917
36IRAK11.27946028
37MST41.27703030
38AKT31.27529351
39PDGFRA1.24276337
40ERN11.23638354
41PLK21.23078591
42CSNK1G11.22963687
43IGF1R1.22193540
44MAP3K21.21029927
45PTK21.15050021
46PAK31.13634250
47PTK61.09253930
48EPHA21.07293537
49SCYL21.06705436
50MAPK101.05273211
51MAP3K121.05130627
52INSR1.03462807
53CSNK1G30.99975857
54STK38L0.96634283
55BRAF0.95588621
56BCKDK0.93819664
57TAOK30.92710532
58ZAP700.90575218
59TRIB30.89343141
60IRAK20.88419891
61CSNK1G20.83348668
62FRK0.82793180
63BMPR20.81803396
64SGK4940.79881166
65SGK2230.79881166
66EPHA30.78303362
67ACVR1B0.77604427
68DYRK1B0.77175605
69* PRKCB0.76555814
70STK110.76121519
71CAMKK20.75550556
72TNK20.74532784
73OXSR10.73048508
74PTK2B0.70598548
75ERBB20.70266395
76BMPR1B0.69839587
77PINK10.69017912
78PRKCI0.68826725
79PNCK0.66511379
80FER0.65841141
81CASK0.64539444
82BRD40.64021527
83PRKACG0.61761029
84CSNK1A1L0.61732996
85JAK10.60093505
86PRKACB0.59404012
87PRKAA10.58564708
88CDC42BPA0.58368128
89PRKCE0.57826084
90MAP2K20.55562715
91RPS6KA20.55240750
92ROCK20.54339049
93CAMK1G0.53702726
94PRKG20.53133498
95STK40.48384048
96DAPK10.47217724
97* RPS6KA30.46914995
98MAP3K10.46902070
99PRKCH0.46856722
100STK240.45764201
101CAMKK10.44352238
102ADRBK10.43767864
103ZAK0.43052432
104CSNK1D0.42813730
105YES10.41250513
106PRKAA20.40994061
107CDK50.38913442
108CAMK2A0.38412775
109PAK60.36953709
110DYRK20.35754996
111PRKCQ0.35678775
112CHUK0.35588263
113ERBB30.34620358
114PRKD20.34483677
115MAPK130.34473218
116STK380.34362645
117MAP2K70.33938564
118DYRK1A0.33536593
119MAP3K100.33322743
120MAP2K40.32879635
121JAK30.32578162
122AKT20.32117150
123PRKACA0.31449785
124MAP3K40.31077786
125RPS6KB10.30564859
126PRKCA0.29516571
127MINK10.29368494
128EPHB20.29063263
129PKN10.27502209
130PRKCG0.27473375
131MAPKAPK30.27047050
132CSNK2A20.26742744
133PKN20.26420548
134MYLK0.25947841
135ITK0.25941867
136MAP2K10.25597371
137LMTK20.25345939
138CAMK2D0.24979796
139CSNK1E0.24195972
140PRKCZ0.24185763
141NTRK20.23938525
142EIF2AK30.23615703
143LIMK10.21782887
144MAPKAPK20.21513239
145RPS6KA10.19723615
146CSK0.19449069
147TESK10.19156997
148ALK0.18955280
149MARK30.18763873
150CSNK1A10.18198549
151DAPK20.18114828
152SRPK10.17469928
153EGFR0.17467602

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.52639102
2Protein export_Homo sapiens_hsa030604.57893724
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.64422238
4Insulin secretion_Homo sapiens_hsa049113.37150149
5Vibrio cholerae infection_Homo sapiens_hsa051102.48713499
6Sulfur metabolism_Homo sapiens_hsa009202.14026251
7Vitamin B6 metabolism_Homo sapiens_hsa007502.05484801
8Cocaine addiction_Homo sapiens_hsa050302.01593282
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00796512
10Type II diabetes mellitus_Homo sapiens_hsa049301.96274388
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.93719529
12Synaptic vesicle cycle_Homo sapiens_hsa047211.87837822
13Type I diabetes mellitus_Homo sapiens_hsa049401.71141631
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69622672
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69139737
16Circadian rhythm_Homo sapiens_hsa047101.64158871
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61610369
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55692573
19Glutathione metabolism_Homo sapiens_hsa004801.55689111
20Amphetamine addiction_Homo sapiens_hsa050311.54642581
21Circadian entrainment_Homo sapiens_hsa047131.48971085
22Arginine biosynthesis_Homo sapiens_hsa002201.47392776
23GABAergic synapse_Homo sapiens_hsa047271.45066149
24Serotonergic synapse_Homo sapiens_hsa047261.44900722
25Phototransduction_Homo sapiens_hsa047441.41547193
26N-Glycan biosynthesis_Homo sapiens_hsa005101.38478386
27Fatty acid elongation_Homo sapiens_hsa000621.37025020
28Peroxisome_Homo sapiens_hsa041461.34928061
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32029414
30Glucagon signaling pathway_Homo sapiens_hsa049221.30350146
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26704982
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26406467
33Dopaminergic synapse_Homo sapiens_hsa047281.22830378
34Prion diseases_Homo sapiens_hsa050201.21408570
35Sphingolipid metabolism_Homo sapiens_hsa006001.18369555
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08848413
37Folate biosynthesis_Homo sapiens_hsa007901.06765269
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05801785
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03459352
40Phenylalanine metabolism_Homo sapiens_hsa003600.99315478
41Propanoate metabolism_Homo sapiens_hsa006400.97935898
42Tryptophan metabolism_Homo sapiens_hsa003800.97463732
43Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96843802
44Cholinergic synapse_Homo sapiens_hsa047250.93667237
45Taste transduction_Homo sapiens_hsa047420.91011332
46Mineral absorption_Homo sapiens_hsa049780.90614900
47Sulfur relay system_Homo sapiens_hsa041220.88856574
48Long-term potentiation_Homo sapiens_hsa047200.87445562
49Nitrogen metabolism_Homo sapiens_hsa009100.86722009
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86409406
51Insulin signaling pathway_Homo sapiens_hsa049100.86007627
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85887616
53Morphine addiction_Homo sapiens_hsa050320.85401952
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.85037334
55Melanogenesis_Homo sapiens_hsa049160.83158589
56Collecting duct acid secretion_Homo sapiens_hsa049660.82410846
57Estrogen signaling pathway_Homo sapiens_hsa049150.81487737
58Lysosome_Homo sapiens_hsa041420.81263510
59Histidine metabolism_Homo sapiens_hsa003400.80590930
60Thyroid hormone synthesis_Homo sapiens_hsa049180.77959339
61Retinol metabolism_Homo sapiens_hsa008300.77388684
62Selenocompound metabolism_Homo sapiens_hsa004500.75728514
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75546508
64Regulation of autophagy_Homo sapiens_hsa041400.75101860
65Hedgehog signaling pathway_Homo sapiens_hsa043400.74239072
66Linoleic acid metabolism_Homo sapiens_hsa005910.74184551
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72069001
68beta-Alanine metabolism_Homo sapiens_hsa004100.71919752
69Metabolic pathways_Homo sapiens_hsa011000.71688365
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71498896
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.70527648
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69326873
73ABC transporters_Homo sapiens_hsa020100.68915156
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68876142
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66933013
76Insulin resistance_Homo sapiens_hsa049310.66451907
77mTOR signaling pathway_Homo sapiens_hsa041500.65973154
78Long-term depression_Homo sapiens_hsa047300.65674363
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64894391
80Cardiac muscle contraction_Homo sapiens_hsa042600.64227689
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63943748
82Fatty acid metabolism_Homo sapiens_hsa012120.63616714
83Fat digestion and absorption_Homo sapiens_hsa049750.63479100
84Renin secretion_Homo sapiens_hsa049240.63193407
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62634447
86Prolactin signaling pathway_Homo sapiens_hsa049170.61924136
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60850057
88Protein digestion and absorption_Homo sapiens_hsa049740.59263429
89Chemical carcinogenesis_Homo sapiens_hsa052040.57656801
90Alcoholism_Homo sapiens_hsa050340.57215315
91Glutamatergic synapse_Homo sapiens_hsa047240.57116208
92Pancreatic secretion_Homo sapiens_hsa049720.55600688
93Wnt signaling pathway_Homo sapiens_hsa043100.55354486
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.54571624
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53974992
96Olfactory transduction_Homo sapiens_hsa047400.52807303
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51609204
98Legionellosis_Homo sapiens_hsa051340.51518244
99Huntingtons disease_Homo sapiens_hsa050160.50753204
100Tyrosine metabolism_Homo sapiens_hsa003500.50747260
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50478866
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50051545
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49733630
104Steroid biosynthesis_Homo sapiens_hsa001000.49424798
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.49149581
106Calcium signaling pathway_Homo sapiens_hsa040200.49094807
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49073899
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48433038
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.48355418
110Gap junction_Homo sapiens_hsa045400.45292228
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44273770
112Alzheimers disease_Homo sapiens_hsa050100.43609208
113cAMP signaling pathway_Homo sapiens_hsa040240.43395308
114Salivary secretion_Homo sapiens_hsa049700.43261723
115Oxidative phosphorylation_Homo sapiens_hsa001900.43225729
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.42934163
117Butanoate metabolism_Homo sapiens_hsa006500.42841095
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42014863
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.41644142
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38255928
121Dorso-ventral axis formation_Homo sapiens_hsa043200.37641324
122Gastric acid secretion_Homo sapiens_hsa049710.37324167
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37159792
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36521086
125Ether lipid metabolism_Homo sapiens_hsa005650.36480217
126Inositol phosphate metabolism_Homo sapiens_hsa005620.36043396
127Starch and sucrose metabolism_Homo sapiens_hsa005000.35909359
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35423136
129Oxytocin signaling pathway_Homo sapiens_hsa049210.35348168
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.34619897
131Fatty acid degradation_Homo sapiens_hsa000710.34468378
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33238561
133Ovarian steroidogenesis_Homo sapiens_hsa049130.33010678
134Galactose metabolism_Homo sapiens_hsa000520.32035002
135Other glycan degradation_Homo sapiens_hsa005110.30720198
136Renal cell carcinoma_Homo sapiens_hsa052110.29697068
137Parkinsons disease_Homo sapiens_hsa050120.29536406
138Amoebiasis_Homo sapiens_hsa051460.29300356
139Glioma_Homo sapiens_hsa052140.29136621
140ErbB signaling pathway_Homo sapiens_hsa040120.23815434
141Basal cell carcinoma_Homo sapiens_hsa052170.23545746
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22833685
143Phagosome_Homo sapiens_hsa041450.22551416

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