ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytolysis (GO:0019835)	8.42938078
2	* visual perception (GO:0007601)	8.34906130
3	camera-type eye development (GO:0043010)	8.30090260
4	* sensory perception of light stimulus (GO:0050953)	8.24887821
5	histone H3-K9 demethylation (GO:0033169)	7.80554075
6	muscle cell cellular homeostasis (GO:0046716)	7.72133966
7	protein refolding (GO:0042026)	7.70089535
8	bile acid and bile salt transport (GO:0015721)	7.01295044
9	cellular response to osmotic stress (GO:0071470)	6.96009045
10	regulation of protein sumoylation (GO:0033233)	6.92963984
11	eye development (GO:0001654)	6.68322238
12	myofibril assembly (GO:0030239)	6.34246893
13	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	5.17976188
14	sensory organ development (GO:0007423)	5.11620180
15	response to salt stress (GO:0009651)	4.92634096
16	negative regulation of homotypic cell-cell adhesion (GO:0034111)	4.74468504
17	insulin-like growth factor receptor signaling pathway (GO:0048009)	4.70116413
18	sarcomere organization (GO:0045214)	4.64578946
19	regulation of myoblast differentiation (GO:0045661)	4.09744067
20	* lens development in camera-type eye (GO:0002088)	33.7702650
21	protein homotrimerization (GO:0070207)	3.88769096
22	* sensory perception (GO:0007600)	3.82671641
23	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.76372885
24	lung epithelium development (GO:0060428)	3.64153659
25	regulation of Rac protein signal transduction (GO:0035020)	3.48745449
26	water transport (GO:0006833)	3.43420544
27	regulation of platelet aggregation (GO:0090330)	3.37475806
28	positive regulation of wound healing (GO:0090303)	3.27033392
29	positive regulation of calcium ion transport into cytosol (GO:0010524)	3.25297034
30	regulation of skeletal muscle fiber development (GO:0048742)	3.18041341
31	intermediate filament cytoskeleton organization (GO:0045104)	3.05101265
32	cellular response to calcium ion (GO:0071277)	3.01129253
33	lens fiber cell development (GO:0070307)	27.4682589
34	lens fiber cell differentiation (GO:0070306)	21.6093695
35	fluid transport (GO:0042044)	2.95719179
36	intermediate filament-based process (GO:0045103)	2.93638878
37	response to activity (GO:0014823)	2.74853662
38	histone lysine demethylation (GO:0070076)	2.74046405
39	respiratory tube development (GO:0030323)	2.72414433
40	dopaminergic neuron differentiation (GO:0071542)	2.71727890
41	cerebellar granule cell differentiation (GO:0021707)	2.71373543
42	negative regulation of platelet activation (GO:0010544)	2.65718888
43	skeletal muscle organ development (GO:0060538)	2.59576699
44	activation of JUN kinase activity (GO:0007257)	2.56400447
45	lung-associated mesenchyme development (GO:0060484)	2.56064200
46	mating behavior (GO:0007617)	2.55685892
47	histone demethylation (GO:0016577)	2.55474557
48	epithelial cell development (GO:0002064)	2.53612939
49	actomyosin structure organization (GO:0031032)	2.48219690
50	L-alpha-amino acid transmembrane transport (GO:1902475)	2.47401291
51	negative regulation of cell size (GO:0045792)	2.42113276
52	regulation of release of sequestered calcium ion into cytosol (GO:0051279)	2.39807524
53	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	2.39373789
54	regulation of myotube differentiation (GO:0010830)	2.36149823
55	diaphragm development (GO:0060539)	2.30218342
56	response to osmotic stress (GO:0006970)	2.28735902
57	protein demethylation (GO:0006482)	2.25044874
58	protein dealkylation (GO:0008214)	2.25044874
59	basement membrane organization (GO:0071711)	2.23325608
60	cell-cell junction assembly (GO:0007043)	2.22182347
61	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.19205136
62	positive regulation of dendritic spine development (GO:0060999)	2.18090906
63	positive regulation of dendrite morphogenesis (GO:0050775)	2.13518840
64	protein localization to cell surface (GO:0034394)	2.12597202
65	regulation of homotypic cell-cell adhesion (GO:0034110)	2.12154198
66	metanephric tubule development (GO:0072170)	2.09604048
67	metanephric nephron tubule development (GO:0072234)	2.09604048
68	protein trimerization (GO:0070206)	2.04647165
69	neuronal stem cell maintenance (GO:0097150)	2.03213137
70	carnitine shuttle (GO:0006853)	2.00312986
71	lens morphogenesis in camera-type eye (GO:0002089)	11.0389961
72	response to muscle activity (GO:0014850)	10.4746236
73	collecting duct development (GO:0072044)	1.99459851
74	apoptotic process involved in morphogenesis (GO:0060561)	1.97883107
75	negative regulation of hormone metabolic process (GO:0032351)	1.97524097
76	negative regulation of hormone biosynthetic process (GO:0032353)	1.97524097
77	positive regulation of developmental growth (GO:0048639)	1.96882240
78	dorsal/ventral axis specification (GO:0009950)	1.96008869
79	apoptotic process involved in development (GO:1902742)	1.95126337
80	negative regulation of potassium ion transmembrane transport (GO:1901380)	1.92354036
81	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.92013454
82	metanephric nephron epithelium development (GO:0072243)	1.90769952
83	regulation of dendritic spine morphogenesis (GO:0061001)	1.89401459
84	cellular response to vitamin D (GO:0071305)	1.88495841
85	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	1.85913274
86	cell maturation (GO:0048469)	1.85571176
87	negative regulation of JUN kinase activity (GO:0043508)	1.84130186
88	anatomical structure regression (GO:0060033)	1.81162782
89	cellular response to prostaglandin stimulus (GO:0071379)	1.80406793
90	fatty acid transmembrane transport (GO:1902001)	1.76443604
91	cartilage morphogenesis (GO:0060536)	1.75784451
92	regulation of skeletal muscle tissue development (GO:0048641)	1.72593196
93	bone trabecula formation (GO:0060346)	1.71956823
94	regulation of calcium ion transport into cytosol (GO:0010522)	1.71304999
95	regulation of striated muscle cell differentiation (GO:0051153)	1.71030030
96	lung morphogenesis (GO:0060425)	1.66679836
97	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.66447245
98	metanephric epithelium development (GO:0072207)	1.65103877
99	regulation of wound healing (GO:0061041)	1.64597294
100	regulation of bile acid biosynthetic process (GO:0070857)	1.64566838

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	5.53274348
2	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	5.26541226
3	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.03510622
4	IKZF1_21737484_ChIP-ChIP_HCT116_Human	3.38858444
5	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.66629908
6	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	2.57170722
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.14948027
8	* PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.05108309
9	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.03565472
10	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.03294759
11	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.00217245
12	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.00217245
13	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	10.6344867
14	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.99565954
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.99259800
16	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.93767899
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.90524484
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.72196663
19	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.69053913
20	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.64370253
21	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.62885978
22	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.57940002
23	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.57600398
24	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.57017290
25	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.51184985
26	GATA1_22025678_ChIP-Seq_K562_Human	1.49804548
27	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.49727735
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.45654653
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42328075
30	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.39746199
31	* GATA3_24758297_ChIP-Seq_MCF-7_Human	1.38774928
32	* NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35556332
33	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.34430677
34	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.33875703
35	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.31826663
36	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.31281118
37	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.29854457
38	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.29628451
39	CTCF_27219007_Chip-Seq_Bcells_Human	1.29521655
40	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.27844926
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.27601873
42	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.27348922
43	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26000207
44	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.25334442
45	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.24766121
46	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.24687471
47	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.22888609
48	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.22669475
49	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.19906415
50	GATA1_19941827_ChIP-Seq_MEL86_Mouse	1.19886058
51	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19746810
52	LXR_22292898_ChIP-Seq_THP-1_Human	1.18044936
53	ZNF263_19887448_ChIP-Seq_K562_Human	1.17959124
54	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.14618606
55	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.13468967
56	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.13215066
57	VDR_22108803_ChIP-Seq_LS180_Human	1.12307285
58	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.11486237
59	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.11051260
60	* CTCF_18555785_Chip-Seq_ESCs_Mouse	1.10229838
61	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.08646491
62	* SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08250539
63	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.08009133
64	* EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07572225
65	* SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.05215031
66	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.04543207
67	* RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.04421311
68	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.02893622
69	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.01796398
70	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.01103302
71	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.00554532
72	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.00276224
73	ZNF274_21170338_ChIP-Seq_K562_Hela	0.99950177
74	CLOCK_20551151_ChIP-Seq_293T_Human	0.99380513
75	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.97713609
76	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.97327939
77	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.95696496
78	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.95673258
79	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.95337655
80	MYC_18940864_ChIP-ChIP_HL60_Human	0.91744692
81	KDM2B_26808549_Chip-Seq_K562_Human	0.89982488
82	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.88044369
83	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.87821602
84	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.86955599
85	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.85892381
86	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.85856077
87	* PU1_27457419_Chip-Seq_LIVER_Mouse	0.85791579
88	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.84198235
89	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.83996228
90	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.83600159
91	OCT4_19829295_ChIP-Seq_ESCs_Human	0.83411151
92	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.83267467
93	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.82709226
94	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.81570352
95	TCF7_22412390_ChIP-Seq_EML_Mouse	0.81172869
96	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.81086130
97	IGF1R_20145208_ChIP-Seq_DFB_Human	0.80559769
98	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.79870716
99	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.78740461
100	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.77803564

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	* MP0005193_abnormal_anterior_eye	9.06228754
2	MP0005253_abnormal_eye_physiology	4.88515303
3	MP0001286_abnormal_eye_development	4.00292914
4	MP0002092_abnormal_eye_morphology	3.92130289
5	MP0000749_muscle_degeneration	3.86950043
6	MP0005197_abnormal_uvea_morphology	3.86800260
7	MP0003941_abnormal_skin_development	3.50666898
8	MP0005391_vision/eye_phenotype	3.18206750
9	MP0002090_abnormal_vision	2.39961217
10	MP0001346_abnormal_lacrimal_gland	2.28018049
11	* MP0002697_abnormal_eye_size	13.7132127
12	MP0002108_abnormal_muscle_morphology	1.73612750
13	MP0004272_abnormal_basement_membrane	1.69344897
14	MP0002269_muscular_atrophy	1.57747225
15	MP0005330_cardiomyopathy	1.56829939
16	MP0002638_abnormal_pupillary_reflex	1.38601059
17	MP0010368_abnormal_lymphatic_system	1.36637686
18	MP0002139_abnormal_hepatobiliary_system	1.21238986
19	MP0001299_abnormal_eye_distance/	1.13427922
20	MP0002735_abnormal_chemical_nociception	1.09968893
21	MP0005195_abnormal_posterior_eye	1.03413963
22	MP0003705_abnormal_hypodermis_morpholog	1.02127379
23	MP0001340_abnormal_eyelid_morphology	0.93858748
24	MP0005319_abnormal_enzyme/_coenzyme	0.80967371
25	MP0004087_abnormal_muscle_fiber	0.79554716
26	MP0003123_paternal_imprinting	0.76721724
27	MP0004859_abnormal_synaptic_plasticity	0.75485760
28	MP0005369_muscle_phenotype	0.70270849
29	MP0000049_abnormal_middle_ear	0.68046921
30	MP0003252_abnormal_bile_duct	0.64777766
31	MP0009053_abnormal_anal_canal	0.64578582
32	MP0000759_abnormal_skeletal_muscle	0.62938149
33	MP0000537_abnormal_urethra_morphology	0.59292495
34	MP0001905_abnormal_dopamine_level	0.57744079
35	MP0005551_abnormal_eye_electrophysiolog	0.53724016
36	MP0005187_abnormal_penis_morphology	0.53689038
37	MP0005085_abnormal_gallbladder_physiolo	0.53621927
38	MP0002736_abnormal_nociception_after	0.50744224
39	MP0002734_abnormal_mechanical_nocicepti	0.49495456
40	MP0005360_urolithiasis	0.49179588
41	MP0009780_abnormal_chondrocyte_physiolo	0.47461163
42	MP0003566_abnormal_cell_adhesion	0.45825989
43	MP0003787_abnormal_imprinting	0.45456089
44	MP0003656_abnormal_erythrocyte_physiolo	0.44953252
45	MP0002249_abnormal_larynx_morphology	0.44180206
46	MP0002089_abnormal_postnatal_growth/wei	0.43339074
47	MP0001915_intracranial_hemorrhage	0.43131409
48	MP0000747_muscle_weakness	0.42314746
49	MP0004885_abnormal_endolymph	0.42149973
50	MP0003635_abnormal_synaptic_transmissio	0.41979575
51	MP0001968_abnormal_touch/_nociception	0.41909529
52	MP0003329_amyloid_beta_deposits	0.41425520
53	MP0000751_myopathy	0.41190479
54	MP0006292_abnormal_olfactory_placode	0.41110917
55	MP0003115_abnormal_respiratory_system	0.38535432
56	MP0003942_abnormal_urinary_system	0.38057210
57	MP0001879_abnormal_lymphatic_vessel	0.37243800
58	MP0002177_abnormal_outer_ear	0.35300051
59	MP0001958_emphysema	0.35080948
60	MP0009250_abnormal_appendicular_skeleto	0.34003497
61	MP0000428_abnormal_craniofacial_morphol	0.33990437
62	MP0010234_abnormal_vibrissa_follicle	0.33607421
63	MP0005248_abnormal_Harderian_gland	0.32842467
64	MP0001943_abnormal_respiration	0.31656082
65	MP0004134_abnormal_chest_morphology	0.31579269
66	MP0002063_abnormal_learning/memory/cond	0.31343245
67	MP0005623_abnormal_meninges_morphology	0.30642059
68	MP0002653_abnormal_ependyma_morphology	0.30524405
69	MP0008438_abnormal_cutaneous_collagen	0.30161324
70	MP0004197_abnormal_fetal_growth/weight/	0.30136925
71	MP0002295_abnormal_pulmonary_circulatio	0.28946228
72	MP0002925_abnormal_cardiovascular_devel	0.28928749
73	MP0004270_analgesia	0.28894827
74	MP0004811_abnormal_neuron_physiology	0.28798448
75	MP0004858_abnormal_nervous_system	0.28735479
76	MP0002733_abnormal_thermal_nociception	0.28380949
77	MP0003959_abnormal_lean_body	0.28063882
78	MP0005647_abnormal_sex_gland	0.26797935
79	MP0000955_abnormal_spinal_cord	0.26353611
80	MP0005257_abnormal_intraocular_pressure	0.26129393
81	MP0004084_abnormal_cardiac_muscle	0.23674173
82	MP0001784_abnormal_fluid_regulation	0.23081751
83	MP0002106_abnormal_muscle_physiology	0.22981777
84	MP0001614_abnormal_blood_vessel	0.22758316
85	MP0002152_abnormal_brain_morphology	0.22733831
86	MP0003122_maternal_imprinting	0.20840524
87	MP0002128_abnormal_blood_circulation	0.20056230
88	MP0000266_abnormal_heart_morphology	0.19627683
89	MP0002064_seizures	0.19103188
90	MP0002163_abnormal_gland_morphology	0.18999513
91	MP0003119_abnormal_digestive_system	0.18978332
92	MP0000604_amyloidosis	0.18437648
93	MP0008770_decreased_survivor_rate	0.17697239
94	MP0001765_abnormal_ion_homeostasis	0.17536093
95	MP0010329_abnormal_lipoprotein_level	0.17301730
96	MP0005365_abnormal_bile_salt	0.16624557
97	MP0004145_abnormal_muscle_electrophysio	0.15964036
98	MP0004185_abnormal_adipocyte_glucose	0.15749267
99	MP0004233_abnormal_muscle_weight	0.15681448
100	MP0002081_perinatal_lethality	0.15661209

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital cataract (HP:0000519)	7.94523974
2	Corneal dystrophy (HP:0001131)	7.10718287
3	Amblyopia (HP:0000646)	6.96547423
4	Anterior segment dysgenesis (HP:0007700)	5.96383533
5	Polar cataract (HP:0010696)	4.35275774
6	Clumsiness (HP:0002312)	3.95212990
7	Microcornea (HP:0000482)	3.56951851
8	Nuclear cataract (HP:0100018)	27.5842466
9	Zonular cataract (HP:0010920)	24.3176978
10	Iris coloboma (HP:0000612)	2.86026994
11	Eosinophilia (HP:0001880)	2.85799277
12	Opacification of the corneal stroma (HP:0007759)	2.58669177
13	Abnormality of the anterior chamber (HP:0000593)	2.53746488
14	Granulocytopenia (HP:0001913)	2.27959273
15	Sclerocornea (HP:0000647)	2.25466870
16	Scapular winging (HP:0003691)	2.11229191
17	Proximal amyotrophy (HP:0007126)	2.09223457
18	Congenital primary aphakia (HP:0007707)	2.04846709
19	Abnormality of eosinophils (HP:0001879)	1.94262170
20	Aplasia/Hypoplasia of the lens (HP:0008063)	1.75098067
21	Posterior subcapsular cataract (HP:0007787)	1.74412100
22	Neonatal respiratory distress (HP:0002643)	1.64783350
23	Fetal akinesia sequence (HP:0001989)	1.57077572
24	Aplasia/Hypoplasia of the macula (HP:0008059)	1.53103644
25	Popliteal pterygium (HP:0009756)	1.50217128
26	Long clavicles (HP:0000890)	1.48899715
27	Aplasia of the musculature (HP:0100854)	1.46657059
28	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.45766607
29	Amniotic constriction ring (HP:0009775)	1.37237793
30	Abnormality of placental membranes (HP:0011409)	1.37237793
31	Akinesia (HP:0002304)	1.33847880
32	Hypoplastic nipples (HP:0002557)	1.28805450
33	Difficulty walking (HP:0002355)	1.28640050
34	Abnormality of the shoulder girdle musculature (HP:0001435)	1.27714919
35	Leukocytosis (HP:0001974)	1.27518023
36	Rib fusion (HP:0000902)	1.12639387
37	Fused cervical vertebrae (HP:0002949)	1.09129114
38	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.02115530
39	Vertebral clefting (HP:0008428)	0.99898229
40	Abnormality of the labia majora (HP:0012881)	0.95309392
41	Subcapsular cataract (HP:0000523)	0.92342108
42	Aplasia/Hypoplasia involving the musculature (HP:0001460)	0.85641984
43	Exostoses (HP:0100777)	0.81834280
44	Pterygium (HP:0001059)	0.78261876
45	Chorioretinal coloboma (HP:0000567)	0.77420722
46	Camptodactyly of toe (HP:0001836)	0.72378961
47	Lymphangioma (HP:0100764)	0.72350320
48	Malignant hyperthermia (HP:0002047)	0.71966856
49	Thin ribs (HP:0000883)	0.69710713
50	Ependymoma (HP:0002888)	0.68598042
51	Hypoplastic heart (HP:0001961)	0.68452764
52	Neoplasm of the heart (HP:0100544)	0.66959983
53	Abnormal number of incisors (HP:0011064)	0.64814844
54	Diminished movement (HP:0002374)	0.57814349
55	Aplasia/Hypoplasia of the nipples (HP:0006709)	0.57420584
56	Dislocated radial head (HP:0003083)	0.55598957
57	Cystic hygroma (HP:0000476)	0.55505375
58	Severe visual impairment (HP:0001141)	0.54011956
59	Abnormality of the humeroradial joint (HP:0100744)	0.53452845
60	Pointed chin (HP:0000307)	0.52979598
61	Muscle fiber splitting (HP:0003555)	0.52466767
62	Enlarged kidneys (HP:0000105)	0.52292438
63	Split foot (HP:0001839)	0.51989209
64	Abnormality of the radial head (HP:0003995)	0.51351110
65	Hepatoblastoma (HP:0002884)	0.50036908
66	Hypoplastic pelvis (HP:0008839)	0.49832188
67	Joint contractures involving the joints of the feet (HP:0100492)	0.49588528
68	Flexion contracture of toe (HP:0005830)	0.49588528
69	Astrocytoma (HP:0009592)	0.49313718
70	Abnormality of the astrocytes (HP:0100707)	0.49313718
71	Autosomal dominant inheritance (HP:0000006)	0.49216799
72	Visceral angiomatosis (HP:0100761)	0.48210308
73	Annular pancreas (HP:0001734)	0.47269429
74	Skin nodule (HP:0200036)	0.46858414
75	Hyporeflexia of lower limbs (HP:0002600)	0.46667580
76	Hamartoma of the eye (HP:0010568)	0.45976752
77	Abnormality of cochlea (HP:0000375)	0.45954574
78	Neonatal hypoglycemia (HP:0001998)	0.44576558
79	Buphthalmos (HP:0000557)	0.44467177
80	Patellar aplasia (HP:0006443)	0.44286544
81	Hemangiomatosis (HP:0007461)	0.43682195
82	Hemiplegia (HP:0002301)	0.43237312
83	Abnormality of the labia (HP:0000058)	0.42809036
84	Broad nasal tip (HP:0000455)	0.42580211
85	Deep venous thrombosis (HP:0002625)	0.41441235
86	Exercise-induced muscle cramps (HP:0003710)	0.39984375
87	Humeroradial synostosis (HP:0003041)	0.39540430
88	Synostosis involving the elbow (HP:0003938)	0.39540430
89	Exercise-induced myalgia (HP:0003738)	0.39282032
90	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	0.39050829
91	Aplasia/Hypoplasia of the patella (HP:0006498)	0.38847590
92	Adenoma sebaceum (HP:0009720)	0.38422019
93	Angiofibromas (HP:0010615)	0.38422019
94	Abnormal pancreas size (HP:0012094)	0.38151137
95	Abnormalities of placenta or umbilical cord (HP:0001194)	0.36443973
96	Hyperthyroidism (HP:0000836)	0.36242769
97	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	0.36108769
98	Overgrowth (HP:0001548)	0.36000821
99	Hypopigmentation of the fundus (HP:0007894)	0.34991844
100	Vertebral fusion (HP:0002948)	0.34363017

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K6	8.35915746
2	BLK	4.93731608
3	SGK1	4.21009584
4	STK39	3.15697571
5	WNK4	2.99409677
6	MST4	2.84558093
7	NTRK1	2.79604985
8	FLT3	2.78404200
9	PRKG1	2.60834265
10	PKN2	2.36515743
11	SIK1	2.29729180
12	TRIB3	2.15127483
13	MET	1.83082403
14	PDGFRA	1.72965437
15	IGF1R	1.71761482
16	LRRK2	1.71085959
17	PRKCB	1.64305026
18	INSR	1.49673846
19	MAPK10	1.48897588
20	EPHB2	1.38835727
21	PNCK	1.37031153
22	PRKACB	1.19847472
23	ZAP70	1.18293204
24	ERBB2	1.15553349
25	CDK6	1.14355243
26	EPHA4	1.14076505
27	STK10	1.13668394
28	PTK6	1.12570913
29	WNK1	1.12164773
30	ICK	1.11531269
31	PAK4	1.08727949
32	RPS6KA3	1.04837441
33	MAP3K10	1.04644272
34	SCYL2	0.89711045
35	PRKCQ	0.89088447
36	PTK2	0.88042830
37	ROCK2	0.87728699
38	PAK6	0.81561693
39	PKN1	0.76168508
40	ILK	0.76003872
41	CAMKK1	0.75697459
42	PRKACG	0.74895578
43	PHKG1	0.73949839
44	PHKG2	0.73949839
45	CSF1R	0.71676053
46	PAK3	0.70251013
47	EPHA2	0.67649566
48	LATS1	0.63171321
49	CAMK1G	0.62500173
50	LATS2	0.62388297
51	SGK223	0.59892006
52	SGK494	0.59892006
53	MINK1	0.55323552
54	ROCK1	0.55173460
55	FGFR1	0.53612723
56	MAPKAPK5	0.51953181
57	RPS6KA2	0.51782376
58	CSNK2A2	0.48926804
59	UHMK1	0.44766505
60	CDK5	0.41204559
61	NTRK3	0.40456968
62	PTK2B	0.40412258
63	ALK	0.39830441
64	EGFR	0.38385009
65	ADRBK1	0.35154866
66	PAK2	0.35080930
67	PDGFRB	0.33744510
68	RPS6KA1	0.33726317
69	KSR1	0.32849030
70	NEK9	0.32824235
71	PRKCH	0.32427888
72	FER	0.31817486
73	TTN	0.30159060
74	CSNK1E	0.29018857
75	KSR2	0.28332634
76	JAK3	0.27926533
77	MAP3K8	0.27314300
78	HIPK2	0.25518066
79	MAP3K9	0.24752014
80	MARK1	0.24747209
81	RPS6KC1	0.24731322
82	RPS6KL1	0.24731322
83	CDK14	0.23393512
84	TBK1	0.22212519
85	FYN	0.22192274
86	MKNK1	0.21974891
87	DYRK2	0.21703818
88	BMX	0.21691921
89	PRKCA	0.20766128
90	FGR	0.19447028
91	MAPKAPK2	0.19054488
92	CSNK1A1L	0.17839298
93	AKT2	0.17083192
94	DMPK	0.16840658
95	SRC	0.16328531
96	FGFR2	0.16207988
97	DAPK2	0.16133037
98	LIMK1	0.16093831
99	CDK4	0.15916401
100	CDK15	0.15654236

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.43901160
2	Small cell lung cancer_Homo sapiens_hsa05222	2.42074732
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.10418852
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.04921855
5	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.02847061
6	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.95438865
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.91463820
8	Basal cell carcinoma_Homo sapiens_hsa05217	1.87383613
9	Adherens junction_Homo sapiens_hsa04520	1.75605491
10	Melanogenesis_Homo sapiens_hsa04916	1.62880003
11	Arginine biosynthesis_Homo sapiens_hsa00220	1.62131529
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.61928612
13	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.55835841
14	mTOR signaling pathway_Homo sapiens_hsa04150	1.53697098
15	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.52194292
16	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.47454024
17	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.42838217
18	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.40982720
19	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.37093581
20	ECM-receptor interaction_Homo sapiens_hsa04512	1.32576119
21	Proteoglycans in cancer_Homo sapiens_hsa05205	1.27843937
22	Circadian entrainment_Homo sapiens_hsa04713	1.27825068
23	Insulin signaling pathway_Homo sapiens_hsa04910	1.26007366
24	Fatty acid degradation_Homo sapiens_hsa00071	1.25772326
25	Amoebiasis_Homo sapiens_hsa05146	1.24305671
26	Glioma_Homo sapiens_hsa05214	1.22663779
27	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.20046307
28	GABAergic synapse_Homo sapiens_hsa04727	1.14390551
29	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.13532361
30	Olfactory transduction_Homo sapiens_hsa04740	1.13482653
31	Bile secretion_Homo sapiens_hsa04976	1.13475579
32	Wnt signaling pathway_Homo sapiens_hsa04310	1.13124440
33	Glucagon signaling pathway_Homo sapiens_hsa04922	1.12084348
34	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.11523939
35	Long-term potentiation_Homo sapiens_hsa04720	1.11028650
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06438902
37	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.03448570
38	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.03207805
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01967421
40	Protein digestion and absorption_Homo sapiens_hsa04974	1.00058967
41	Focal adhesion_Homo sapiens_hsa04510	0.97962575
42	Axon guidance_Homo sapiens_hsa04360	0.97442280
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.95936862
44	Sulfur metabolism_Homo sapiens_hsa00920	0.94314779
45	Hippo signaling pathway_Homo sapiens_hsa04390	0.93988214
46	Tight junction_Homo sapiens_hsa04530	0.92304948
47	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.92002588
48	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.91023826
49	Renal cell carcinoma_Homo sapiens_hsa05211	0.90901337
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.90892542
51	Gap junction_Homo sapiens_hsa04540	0.90800641
52	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.88192027
53	Type II diabetes mellitus_Homo sapiens_hsa04930	0.87811040
54	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.87789866
55	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.87574468
56	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.86101262
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85595299
58	Butanoate metabolism_Homo sapiens_hsa00650	0.85323095
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.83441481
60	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.83432243
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.82244540
62	Pathways in cancer_Homo sapiens_hsa05200	0.79949156
63	Vibrio cholerae infection_Homo sapiens_hsa05110	0.78747864
64	Insulin resistance_Homo sapiens_hsa04931	0.77120912
65	Gastric acid secretion_Homo sapiens_hsa04971	0.76090266
66	Estrogen signaling pathway_Homo sapiens_hsa04915	0.75305741
67	Cholinergic synapse_Homo sapiens_hsa04725	0.74645592
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.73551273
69	Prion diseases_Homo sapiens_hsa05020	0.73411541
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.72771201
71	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.72700073
72	Carbon metabolism_Homo sapiens_hsa01200	0.72363945
73	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.72152246
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.72142772
75	Insulin secretion_Homo sapiens_hsa04911	0.71220515
76	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.64938900
77	Thyroid cancer_Homo sapiens_hsa05216	0.64338983
78	ErbB signaling pathway_Homo sapiens_hsa04012	0.63291345
79	PPAR signaling pathway_Homo sapiens_hsa03320	0.62475460
80	Complement and coagulation cascades_Homo sapiens_hsa04610	0.61441152
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60604444
82	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.60147684
83	Long-term depression_Homo sapiens_hsa04730	0.59747396
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59556103
85	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.59426182
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.59167544
87	Glutathione metabolism_Homo sapiens_hsa00480	0.58192198
88	Rap1 signaling pathway_Homo sapiens_hsa04015	0.57162735
89	Amphetamine addiction_Homo sapiens_hsa05031	0.56832633
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56418866
91	AMPK signaling pathway_Homo sapiens_hsa04152	0.56226441
92	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.56135922
93	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55708203
94	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.55368806
95	Toxoplasmosis_Homo sapiens_hsa05145	0.54319020
96	MicroRNAs in cancer_Homo sapiens_hsa05206	0.54056959
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.53421557
98	Bladder cancer_Homo sapiens_hsa05219	0.52591087
99	Cocaine addiction_Homo sapiens_hsa05030	0.46334831
100	Morphine addiction_Homo sapiens_hsa05032	0.45814540

CRYGA

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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