CRYGEP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.52105487
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.05584360
3establishment of integrated proviral latency (GO:0075713)5.45890870
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.44209620
5chromatin remodeling at centromere (GO:0031055)5.03103884
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.01140259
7ATP synthesis coupled proton transport (GO:0015986)5.01140259
8CENP-A containing nucleosome assembly (GO:0034080)4.91224341
9proteasome assembly (GO:0043248)4.82015920
10rRNA modification (GO:0000154)4.53038971
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.40019624
12termination of RNA polymerase III transcription (GO:0006386)4.40019624
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.39921621
14ribosomal small subunit assembly (GO:0000028)4.34266476
15regulation of mitochondrial translation (GO:0070129)4.32754918
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.30081322
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.28658047
18regulation of helicase activity (GO:0051095)4.27956401
19establishment of viral latency (GO:0019043)4.24881478
20DNA replication checkpoint (GO:0000076)4.23966214
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.23127121
22histone exchange (GO:0043486)4.18423685
23regulation of mitotic spindle checkpoint (GO:1903504)4.11078913
24regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.11078913
25spliceosomal snRNP assembly (GO:0000387)4.10731965
26respiratory electron transport chain (GO:0022904)4.07447038
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.05711670
28negative regulation of ligase activity (GO:0051352)4.01327690
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.01327690
30purine nucleobase biosynthetic process (GO:0009113)3.98553000
31electron transport chain (GO:0022900)3.97187424
32DNA replication-independent nucleosome assembly (GO:0006336)3.96404287
33DNA replication-independent nucleosome organization (GO:0034724)3.96404287
34rRNA methylation (GO:0031167)3.91788947
35protein neddylation (GO:0045116)3.90464944
36pseudouridine synthesis (GO:0001522)3.85916527
37DNA strand elongation involved in DNA replication (GO:0006271)3.84569907
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80797073
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.80797073
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76795154
41nucleobase biosynthetic process (GO:0046112)3.70721067
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70368213
43telomere maintenance via semi-conservative replication (GO:0032201)3.68376019
44ribosomal large subunit biogenesis (GO:0042273)3.60312629
45DNA strand elongation (GO:0022616)3.59844217
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.58058338
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.58058338
48protein targeting to mitochondrion (GO:0006626)3.54673859
49viral transcription (GO:0019083)3.53729742
50translational termination (GO:0006415)3.51475399
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.50888335
52negative regulation of sister chromatid segregation (GO:0033046)3.50888335
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.50888335
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.50888335
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.50888335
56IMP biosynthetic process (GO:0006188)3.46128733
57negative regulation of chromosome segregation (GO:0051985)3.42421517
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.40567350
59L-serine metabolic process (GO:0006563)3.39813497
60protein complex biogenesis (GO:0070271)3.36117937
61ribosome assembly (GO:0042255)3.34559152
62mitotic metaphase plate congression (GO:0007080)3.34135483
63mitochondrial respiratory chain complex assembly (GO:0033108)3.33276336
64rRNA processing (GO:0006364)3.30459627
65histone mRNA metabolic process (GO:0008334)3.30434592
66regulation of nuclear cell cycle DNA replication (GO:0033262)3.29839129
67translation (GO:0006412)3.28289300
68establishment of protein localization to mitochondrion (GO:0072655)3.27929477
69regulation of cellular amino acid metabolic process (GO:0006521)3.27353624
70oxidative phosphorylation (GO:0006119)3.26735069
71maturation of SSU-rRNA (GO:0030490)3.26579042
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20110095
73protein localization to mitochondrion (GO:0070585)3.19686526
74DNA double-strand break processing (GO:0000729)3.18561103
75ribosomal small subunit biogenesis (GO:0042274)3.17671546
76rRNA metabolic process (GO:0016072)3.17218014
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16771993
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16552969
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16552969
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16552969
81DNA damage response, detection of DNA damage (GO:0042769)3.16160058
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16150942
83cotranslational protein targeting to membrane (GO:0006613)3.15937831
84telomere maintenance via recombination (GO:0000722)3.14240688
85translational initiation (GO:0006413)3.13582472
86protein targeting to ER (GO:0045047)3.11268202
87signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11092937
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11092937
89mitotic spindle checkpoint (GO:0071174)3.10018815
90mitochondrial respiratory chain complex I assembly (GO:0032981)3.08528393
91NADH dehydrogenase complex assembly (GO:0010257)3.08528393
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08528393
93respiratory chain complex IV assembly (GO:0008535)3.08484087
94regulation of ubiquitin-protein transferase activity (GO:0051438)3.08193385
95peptidyl-histidine modification (GO:0018202)3.07824768
96spindle checkpoint (GO:0031577)3.06746701
97signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05996041
98signal transduction involved in DNA damage checkpoint (GO:0072422)3.05996041
99positive regulation of ligase activity (GO:0051351)3.05266553
100translational elongation (GO:0006414)3.04559056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.90322879
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.37582497
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.33709765
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.11048079
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.08749167
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.78355804
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37656789
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23767785
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21972705
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.14627257
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.10437948
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.10367126
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03984270
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90889889
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90666125
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84217359
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80298704
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63796037
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49325304
20ELK1_19687146_ChIP-ChIP_HELA_Human2.38248655
21FOXP3_21729870_ChIP-Seq_TREG_Human2.35553873
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35021630
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26825187
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25023783
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19067289
26VDR_23849224_ChIP-Seq_CD4+_Human2.18345514
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09738138
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07051742
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04699304
30TTF2_22483619_ChIP-Seq_HELA_Human2.02395921
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.91308651
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.88581050
33XRN2_22483619_ChIP-Seq_HELA_Human1.86383284
34DCP1A_22483619_ChIP-Seq_HELA_Human1.85191102
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72692201
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70288521
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69846251
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67319383
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.67298176
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.67093483
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65818920
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64344795
43MYC_18940864_ChIP-ChIP_HL60_Human1.62472742
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.59872714
45GABP_19822575_ChIP-Seq_HepG2_Human1.58040440
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57162974
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.55174827
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54942761
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49602416
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48558755
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46641844
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44883890
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44422044
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44422044
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44422044
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42888204
57AR_21909140_ChIP-Seq_LNCAP_Human1.41813702
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40861155
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.34769032
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28259889
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27530357
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24611164
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24521520
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.22353105
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21481451
66EWS_26573619_Chip-Seq_HEK293_Human1.19133887
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10734304
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09436092
69NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08851914
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03178455
71VDR_22108803_ChIP-Seq_LS180_Human1.00166486
72ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97613230
73ELK1_22589737_ChIP-Seq_MCF10A_Human0.96993095
74ZNF274_21170338_ChIP-Seq_K562_Hela0.96879203
75FUS_26573619_Chip-Seq_HEK293_Human0.95120217
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94803081
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94279340
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93808731
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91954588
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91872627
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89346039
82KDM5A_27292631_Chip-Seq_BREAST_Human0.88727794
83SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88643392
84FLI1_27457419_Chip-Seq_LIVER_Mouse0.87417962
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85952837
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85848622
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.85787230
88TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84401295
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84071716
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83079326
91TP63_19390658_ChIP-ChIP_HaCaT_Human0.82323483
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82296783
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.81958289
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80979230
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79695681
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77321278
97IRF1_19129219_ChIP-ChIP_H3396_Human0.76569422
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70583103
99NANOG_18692474_ChIP-Seq_MEFs_Mouse0.67390240
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.65259187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.48198088
2MP0003941_abnormal_skin_development4.34480814
3MP0003693_abnormal_embryo_hatching4.28920039
4MP0004957_abnormal_blastocyst_morpholog3.99637299
5MP0006292_abnormal_olfactory_placode3.94881945
6MP0010094_abnormal_chromosome_stability3.80684330
7MP0003111_abnormal_nucleus_morphology3.59864581
8MP0003718_maternal_effect2.93318546
9MP0003077_abnormal_cell_cycle2.87578910
10MP0008877_abnormal_DNA_methylation2.81304422
11MP0008007_abnormal_cellular_replicative2.75606373
12MP0008932_abnormal_embryonic_tissue2.57422497
13MP0009379_abnormal_foot_pigmentation2.56088752
14MP0008057_abnormal_DNA_replication2.41097509
15MP0002254_reproductive_system_inflammat2.23250204
16MP0001293_anophthalmia2.21323260
17MP0001188_hyperpigmentation1.98131293
18MP0006035_abnormal_mitochondrial_morpho1.92590543
19MP0006072_abnormal_retinal_apoptosis1.91216265
20MP0003186_abnormal_redox_activity1.88789004
21MP0003567_abnormal_fetal_cardiomyocyte1.78145562
22MP0006036_abnormal_mitochondrial_physio1.77716564
23MP0003786_premature_aging1.77585093
24MP0004133_heterotaxia1.73789249
25MP0001529_abnormal_vocalization1.73113295
26MP0003806_abnormal_nucleotide_metabolis1.70699081
27MP0003890_abnormal_embryonic-extraembry1.67473972
28MP0002736_abnormal_nociception_after1.64792268
29MP0003121_genomic_imprinting1.62975589
30MP0009672_abnormal_birth_weight1.59206136
31MP0000579_abnormal_nail_morphology1.56546655
32MP0003136_yellow_coat_color1.55829006
33MP0003195_calcinosis1.50832500
34MP0000350_abnormal_cell_proliferation1.47447792
35MP0003011_delayed_dark_adaptation1.46599516
36MP0001730_embryonic_growth_arrest1.42614140
37MP0009697_abnormal_copulation1.40753557
38MP0002277_abnormal_respiratory_mucosa1.31463567
39MP0002938_white_spotting1.20675537
40MP0003119_abnormal_digestive_system1.20146341
41MP0002751_abnormal_autonomic_nervous1.17784922
42MP0003937_abnormal_limbs/digits/tail_de1.17700122
43MP0008995_early_reproductive_senescence1.16399025
44MP0002102_abnormal_ear_morphology1.15955038
45MP0002085_abnormal_embryonic_tissue1.14814594
46MP0003787_abnormal_imprinting1.07283334
47MP0001485_abnormal_pinna_reflex1.04824655
48MP0001286_abnormal_eye_development1.04625095
49MP0000313_abnormal_cell_death1.04374286
50MP0001764_abnormal_homeostasis1.03383496
51MP0001697_abnormal_embryo_size1.03343921
52MP0005395_other_phenotype1.03039890
53MP0003283_abnormal_digestive_organ1.01899094
54MP0003122_maternal_imprinting1.00659978
55MP0001177_atelectasis1.00394478
56MP0002210_abnormal_sex_determination1.00213759
57MP0008789_abnormal_olfactory_epithelium0.96157596
58MP0000631_abnormal_neuroendocrine_gland0.95005410
59MP0002080_prenatal_lethality0.94903044
60MP0001672_abnormal_embryogenesis/_devel0.94758382
61MP0005380_embryogenesis_phenotype0.94758382
62MP0001145_abnormal_male_reproductive0.94007087
63MP0001968_abnormal_touch/_nociception0.93097427
64MP0001929_abnormal_gametogenesis0.92713379
65MP0005084_abnormal_gallbladder_morpholo0.92325746
66MP0000049_abnormal_middle_ear0.91336756
67MP0002233_abnormal_nose_morphology0.90743500
68MP0002697_abnormal_eye_size0.90705875
69MP0002084_abnormal_developmental_patter0.89702083
70MP0002160_abnormal_reproductive_system0.86609863
71MP0000653_abnormal_sex_gland0.86183405
72MP0005075_abnormal_melanosome_morpholog0.86033315
73MP0003123_paternal_imprinting0.85853308
74MP0002111_abnormal_tail_morphology0.85301426
75MP0003938_abnormal_ear_development0.84925247
76MP0004019_abnormal_vitamin_homeostasis0.82104246
77MP0002796_impaired_skin_barrier0.80471897
78MP0008872_abnormal_physiological_respon0.78188121
79MP0002282_abnormal_trachea_morphology0.77503170
80MP0000372_irregular_coat_pigmentation0.76893951
81MP0005645_abnormal_hypothalamus_physiol0.76668976
82MP0001984_abnormal_olfaction0.76250782
83MP0004215_abnormal_myocardial_fiber0.74336785
84MP0002396_abnormal_hematopoietic_system0.70969053
85MP0003984_embryonic_growth_retardation0.69990636
86MP0002088_abnormal_embryonic_growth/wei0.69348216
87MP0009703_decreased_birth_body0.67516289
88MP0005389_reproductive_system_phenotype0.66283317
89MP0004197_abnormal_fetal_growth/weight/0.65490439
90MP0003698_abnormal_male_reproductive0.65304047
91MP0005551_abnormal_eye_electrophysiolog0.64284008
92MP0005253_abnormal_eye_physiology0.63895961
93MP0001727_abnormal_embryo_implantation0.61443550
94MP0010030_abnormal_orbit_morphology0.60481855
95MP0001119_abnormal_female_reproductive0.60286722
96MP0005377_hearing/vestibular/ear_phenot0.59800227
97MP0003878_abnormal_ear_physiology0.59800227
98MP0000678_abnormal_parathyroid_gland0.59784531
99MP0002019_abnormal_tumor_incidence0.59467470
100MP0000358_abnormal_cell_content/0.59289842

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.04878584
2Acute encephalopathy (HP:0006846)4.53216176
3Abnormal mitochondria in muscle tissue (HP:0008316)4.41302178
4Increased hepatocellular lipid droplets (HP:0006565)4.24980774
5Mitochondrial inheritance (HP:0001427)4.14574438
6Progressive macrocephaly (HP:0004481)4.10301464
7Colon cancer (HP:0003003)3.94762918
8Increased CSF lactate (HP:0002490)3.72962239
9Lipid accumulation in hepatocytes (HP:0006561)3.72149453
10Cerebral edema (HP:0002181)3.66108044
11Abnormality of the labia minora (HP:0012880)3.64779753
12Abnormal number of erythroid precursors (HP:0012131)3.60221939
13Oral leukoplakia (HP:0002745)3.49946188
14Abnormality of cells of the erythroid lineage (HP:0012130)3.40213166
15Septo-optic dysplasia (HP:0100842)3.37792650
16Renal Fanconi syndrome (HP:0001994)3.36104162
17Aplastic anemia (HP:0001915)3.32165779
18Hepatocellular necrosis (HP:0001404)3.31813402
19Macrocytic anemia (HP:0001972)3.21169906
20Reticulocytopenia (HP:0001896)2.99260704
21Hyperglycinemia (HP:0002154)2.89122419
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86495919
23Bilateral microphthalmos (HP:0007633)2.83878281
24Methylmalonic acidemia (HP:0002912)2.81829727
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81551477
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81551477
27Multiple enchondromatosis (HP:0005701)2.79361864
28Hepatic necrosis (HP:0002605)2.76903647
29Abnormality of serum amino acid levels (HP:0003112)2.75588807
30Birth length less than 3rd percentile (HP:0003561)2.73020693
31Abnormality of methionine metabolism (HP:0010901)2.72381290
32Meckel diverticulum (HP:0002245)2.63351976
33Leukodystrophy (HP:0002415)2.61577571
34Lactic acidosis (HP:0003128)2.58232695
35Methylmalonic aciduria (HP:0012120)2.56459333
36Exertional dyspnea (HP:0002875)2.53683809
37Increased intramyocellular lipid droplets (HP:0012240)2.51432960
38Hyperglycinuria (HP:0003108)2.51077411
39Abnormality of the ileum (HP:0001549)2.45299009
40Increased serum lactate (HP:0002151)2.45166016
41Respiratory failure (HP:0002878)2.44963289
42Abnormality of glycine metabolism (HP:0010895)2.44071655
43Abnormality of serine family amino acid metabolism (HP:0010894)2.44071655
44Abnormal number of incisors (HP:0011064)2.43299226
45Chromsome breakage (HP:0040012)2.42880652
46Megaloblastic anemia (HP:0001889)2.40460352
47Abnormality of homocysteine metabolism (HP:0010919)2.38738214
48Homocystinuria (HP:0002156)2.38738214
49Abnormal lung lobation (HP:0002101)2.38042807
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37646366
51Microvesicular hepatic steatosis (HP:0001414)2.36218668
52Exercise intolerance (HP:0003546)2.33220428
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32526509
54Pallor (HP:0000980)2.27119368
55Abnormality of renal resorption (HP:0011038)2.26810147
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26593756
57Hypoglycemic seizures (HP:0002173)2.25658383
58Maternal diabetes (HP:0009800)2.20988253
59Respiratory difficulties (HP:0002880)2.20225441
60Abnormality of chromosome stability (HP:0003220)2.20147361
61Type I transferrin isoform profile (HP:0003642)2.14621001
62Congenital, generalized hypertrichosis (HP:0004540)2.14219544
63Absent septum pellucidum (HP:0001331)2.13296552
64Abnormality of the preputium (HP:0100587)2.13107918
65Cellular immunodeficiency (HP:0005374)2.12150858
66Lethargy (HP:0001254)2.09198362
67Ependymoma (HP:0002888)2.07570129
68Pendular nystagmus (HP:0012043)2.05878399
69Abnormality of the septum pellucidum (HP:0007375)2.03221129
70Optic disc pallor (HP:0000543)2.01061650
71Pancreatic islet-cell hyperplasia (HP:0004510)2.00965658
72Pancytopenia (HP:0001876)2.00477815
73Agnosia (HP:0010524)2.00013603
74Aplasia/Hypoplasia of the uvula (HP:0010293)1.96065476
75Abolished electroretinogram (ERG) (HP:0000550)1.94649356
76Increased muscle lipid content (HP:0009058)1.94069445
77Small intestinal stenosis (HP:0012848)1.93069480
78Duodenal stenosis (HP:0100867)1.93069480
79Symptomatic seizures (HP:0011145)1.89865244
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89417141
81Abnormality of alanine metabolism (HP:0010916)1.89417141
82Hyperalaninemia (HP:0003348)1.89417141
83Sparse eyelashes (HP:0000653)1.88705997
84Carpal bone hypoplasia (HP:0001498)1.88529620
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88194950
863-Methylglutaconic aciduria (HP:0003535)1.88034306
87Rough bone trabeculation (HP:0100670)1.87587208
88Restlessness (HP:0000711)1.85690434
89Abnormality of sulfur amino acid metabolism (HP:0004339)1.82446637
90Stenosis of the external auditory canal (HP:0000402)1.81957676
91Gonadotropin excess (HP:0000837)1.81507998
92X-linked dominant inheritance (HP:0001423)1.80748544
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79381721
94Abnormality of the lacrimal duct (HP:0011481)1.79366182
95Selective tooth agenesis (HP:0001592)1.77157825
96Abnormality of the duodenum (HP:0002246)1.76689011
97Hyperinsulinemic hypoglycemia (HP:0000825)1.75706058
98Poor suck (HP:0002033)1.74839238
99Nephroblastoma (Wilms tumor) (HP:0002667)1.74693953
100Cleft eyelid (HP:0000625)1.73408715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.33102711
2BUB14.67310726
3CDC74.54853521
4PBK3.77865914
5SRPK12.96199057
6STK162.81773970
7TTK2.66009314
8TNIK2.65726184
9ZAK2.63363609
10TAF12.57712193
11NME12.52458372
12VRK12.44022552
13PLK32.38339919
14MST42.31056063
15CDK192.30865288
16PLK42.25747401
17TSSK62.15158101
18NUAK12.11618198
19MKNK22.01866271
20NME21.97995526
21MKNK11.97411229
22DYRK21.69084304
23EIF2AK31.67130261
24PLK11.59132599
25NEK11.55776561
26DYRK31.40539141
27BCKDK1.30004120
28ACVR1B1.19381972
29WNK31.16517534
30BRSK21.13981537
31TRIM281.09684093
32EIF2AK11.08192037
33ALK1.02605351
34WEE10.99446698
35ATR0.97061907
36AURKB0.95693012
37PASK0.94610349
38OXSR10.94374620
39CHEK20.91871302
40BMPR1B0.90067970
41STK40.90053388
42CSNK1G10.84545498
43NLK0.81142773
44GRK10.79116697
45EIF2AK20.74079161
46AURKA0.72512565
47NEK20.72272466
48PNCK0.71563672
49CSNK1G20.65400649
50CSNK2A20.63306349
51CSNK2A10.63122069
52ATM0.62750491
53CDK70.62212655
54CHEK10.62102929
55STK38L0.60907096
56PDK20.60644587
57BRSK10.59873096
58CSNK1G30.58500069
59TIE10.57509966
60CDK30.56724364
61INSRR0.54091502
62KDR0.51487949
63PAK40.50034819
64TESK20.48684303
65CSNK1E0.44426542
66ADRBK20.41170318
67PRKDC0.41130594
68MAP4K20.40358959
69CDK20.39887677
70PLK20.39093374
71TEC0.38654637
72PRKCG0.38311415
73CDK10.38060722
74DAPK10.37688125
75RPS6KA40.35153681
76FGFR10.32895034
77PAK10.32721482
78CSNK1A1L0.30803164
79FLT30.30651814
80RPS6KA50.29916105
81CSNK1A10.27868750
82DYRK1A0.27797963
83TLK10.27330371
84ABL20.26005735
85SMG10.24221432
86STK240.23609635
87PIM10.22933796
88PRKG20.20659115
89STK30.19902391
90RPS6KA10.19881327
91UHMK10.17897104
92ERBB40.17224762
93PRKACB0.13760389
94MATK0.11588444
95CAMK10.11176773
96PRKCI0.11065194
97PINK10.10327889
98EGFR0.10179585
99MAP3K100.10077748
100TGFBR10.09539809

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.52026091
2Ribosome_Homo sapiens_hsa030103.86628032
3DNA replication_Homo sapiens_hsa030303.62217209
4Mismatch repair_Homo sapiens_hsa034303.57077799
5RNA polymerase_Homo sapiens_hsa030203.39903854
6Oxidative phosphorylation_Homo sapiens_hsa001903.35423509
7Parkinsons disease_Homo sapiens_hsa050123.05982877
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05418688
9Spliceosome_Homo sapiens_hsa030402.60039064
10Non-homologous end-joining_Homo sapiens_hsa034502.57514256
11Homologous recombination_Homo sapiens_hsa034402.55489147
12Base excision repair_Homo sapiens_hsa034102.33276838
13Huntingtons disease_Homo sapiens_hsa050162.25395826
14Protein export_Homo sapiens_hsa030602.22760671
15RNA transport_Homo sapiens_hsa030132.08629044
16One carbon pool by folate_Homo sapiens_hsa006701.98369624
17Alzheimers disease_Homo sapiens_hsa050101.95693989
18Pyrimidine metabolism_Homo sapiens_hsa002401.88003574
19RNA degradation_Homo sapiens_hsa030181.86173432
20Nucleotide excision repair_Homo sapiens_hsa034201.71333206
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70816837
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70504358
23Basal transcription factors_Homo sapiens_hsa030221.62011811
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56775435
25Pyruvate metabolism_Homo sapiens_hsa006201.55902111
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51577308
27Fanconi anemia pathway_Homo sapiens_hsa034601.49015087
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.48933217
29Purine metabolism_Homo sapiens_hsa002301.43462212
30Cell cycle_Homo sapiens_hsa041101.40419294
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36597876
32Selenocompound metabolism_Homo sapiens_hsa004501.33907693
33Cardiac muscle contraction_Homo sapiens_hsa042601.31028802
34Propanoate metabolism_Homo sapiens_hsa006401.26392535
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23500613
36Glutathione metabolism_Homo sapiens_hsa004801.18463692
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12896574
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07292699
39Biosynthesis of amino acids_Homo sapiens_hsa012301.07204967
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05551252
41Fatty acid elongation_Homo sapiens_hsa000621.01677428
42Vitamin B6 metabolism_Homo sapiens_hsa007501.01486970
43Folate biosynthesis_Homo sapiens_hsa007900.99298722
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98131493
45Vitamin digestion and absorption_Homo sapiens_hsa049770.91880209
46mRNA surveillance pathway_Homo sapiens_hsa030150.90597401
47Carbon metabolism_Homo sapiens_hsa012000.89387938
48Steroid biosynthesis_Homo sapiens_hsa001000.80471169
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72986405
50Metabolic pathways_Homo sapiens_hsa011000.72394276
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69506468
52Oocyte meiosis_Homo sapiens_hsa041140.67320699
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56409369
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54928783
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50153425
56Arginine and proline metabolism_Homo sapiens_hsa003300.49154671
57Sulfur relay system_Homo sapiens_hsa041220.48407067
58Fatty acid degradation_Homo sapiens_hsa000710.46843286
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46818799
60p53 signaling pathway_Homo sapiens_hsa041150.45292056
61Peroxisome_Homo sapiens_hsa041460.45181481
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.44002769
63Retinol metabolism_Homo sapiens_hsa008300.43581688
64Tryptophan metabolism_Homo sapiens_hsa003800.42962751
65Epstein-Barr virus infection_Homo sapiens_hsa051690.41808614
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41475703
67beta-Alanine metabolism_Homo sapiens_hsa004100.41264189
68Galactose metabolism_Homo sapiens_hsa000520.40642988
69Chemical carcinogenesis_Homo sapiens_hsa052040.38227473
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37522615
71Phototransduction_Homo sapiens_hsa047440.35602264
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34198643
73Tyrosine metabolism_Homo sapiens_hsa003500.34076490
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.27909028
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26645030
76Nitrogen metabolism_Homo sapiens_hsa009100.25662748
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24692055
78Butanoate metabolism_Homo sapiens_hsa006500.23229702
79Fat digestion and absorption_Homo sapiens_hsa049750.22587004
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22130549
81Linoleic acid metabolism_Homo sapiens_hsa005910.21953581
82Pentose phosphate pathway_Homo sapiens_hsa000300.21894925
83Fatty acid metabolism_Homo sapiens_hsa012120.21740034
84Wnt signaling pathway_Homo sapiens_hsa043100.19813345
85Caffeine metabolism_Homo sapiens_hsa002320.19166655
86Basal cell carcinoma_Homo sapiens_hsa052170.18394006
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.18344996
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18212692
89Systemic lupus erythematosus_Homo sapiens_hsa053220.17667939
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.17097095
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15696320
92Arachidonic acid metabolism_Homo sapiens_hsa005900.15315268
93TGF-beta signaling pathway_Homo sapiens_hsa043500.14848943
94Arginine biosynthesis_Homo sapiens_hsa002200.14443900
95N-Glycan biosynthesis_Homo sapiens_hsa005100.13346144
96Sulfur metabolism_Homo sapiens_hsa009200.11792717
97Phenylalanine metabolism_Homo sapiens_hsa003600.10465609
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10428886
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08658224
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08350629

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