

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | chaperone-mediated protein transport (GO:0072321) | 6.52105487 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.05584360 |
| 3 | establishment of integrated proviral latency (GO:0075713) | 5.45890870 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.44209620 |
| 5 | chromatin remodeling at centromere (GO:0031055) | 5.03103884 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.01140259 |
| 7 | ATP synthesis coupled proton transport (GO:0015986) | 5.01140259 |
| 8 | CENP-A containing nucleosome assembly (GO:0034080) | 4.91224341 |
| 9 | proteasome assembly (GO:0043248) | 4.82015920 |
| 10 | rRNA modification (GO:0000154) | 4.53038971 |
| 11 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.40019624 |
| 12 | termination of RNA polymerase III transcription (GO:0006386) | 4.40019624 |
| 13 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.39921621 |
| 14 | ribosomal small subunit assembly (GO:0000028) | 4.34266476 |
| 15 | regulation of mitochondrial translation (GO:0070129) | 4.32754918 |
| 16 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.30081322 |
| 17 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.28658047 |
| 18 | regulation of helicase activity (GO:0051095) | 4.27956401 |
| 19 | establishment of viral latency (GO:0019043) | 4.24881478 |
| 20 | DNA replication checkpoint (GO:0000076) | 4.23966214 |
| 21 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.23127121 |
| 22 | histone exchange (GO:0043486) | 4.18423685 |
| 23 | regulation of mitotic spindle checkpoint (GO:1903504) | 4.11078913 |
| 24 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 4.11078913 |
| 25 | spliceosomal snRNP assembly (GO:0000387) | 4.10731965 |
| 26 | respiratory electron transport chain (GO:0022904) | 4.07447038 |
| 27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.05711670 |
| 28 | negative regulation of ligase activity (GO:0051352) | 4.01327690 |
| 29 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.01327690 |
| 30 | purine nucleobase biosynthetic process (GO:0009113) | 3.98553000 |
| 31 | electron transport chain (GO:0022900) | 3.97187424 |
| 32 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.96404287 |
| 33 | DNA replication-independent nucleosome organization (GO:0034724) | 3.96404287 |
| 34 | rRNA methylation (GO:0031167) | 3.91788947 |
| 35 | protein neddylation (GO:0045116) | 3.90464944 |
| 36 | pseudouridine synthesis (GO:0001522) | 3.85916527 |
| 37 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.84569907 |
| 38 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.80797073 |
| 39 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.80797073 |
| 40 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.76795154 |
| 41 | nucleobase biosynthetic process (GO:0046112) | 3.70721067 |
| 42 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.70368213 |
| 43 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.68376019 |
| 44 | ribosomal large subunit biogenesis (GO:0042273) | 3.60312629 |
| 45 | DNA strand elongation (GO:0022616) | 3.59844217 |
| 46 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.58058338 |
| 47 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.58058338 |
| 48 | protein targeting to mitochondrion (GO:0006626) | 3.54673859 |
| 49 | viral transcription (GO:0019083) | 3.53729742 |
| 50 | translational termination (GO:0006415) | 3.51475399 |
| 51 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.50888335 |
| 52 | negative regulation of sister chromatid segregation (GO:0033046) | 3.50888335 |
| 53 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.50888335 |
| 54 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.50888335 |
| 55 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.50888335 |
| 56 | IMP biosynthetic process (GO:0006188) | 3.46128733 |
| 57 | negative regulation of chromosome segregation (GO:0051985) | 3.42421517 |
| 58 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.40567350 |
| 59 | L-serine metabolic process (GO:0006563) | 3.39813497 |
| 60 | protein complex biogenesis (GO:0070271) | 3.36117937 |
| 61 | ribosome assembly (GO:0042255) | 3.34559152 |
| 62 | mitotic metaphase plate congression (GO:0007080) | 3.34135483 |
| 63 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.33276336 |
| 64 | rRNA processing (GO:0006364) | 3.30459627 |
| 65 | histone mRNA metabolic process (GO:0008334) | 3.30434592 |
| 66 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.29839129 |
| 67 | translation (GO:0006412) | 3.28289300 |
| 68 | establishment of protein localization to mitochondrion (GO:0072655) | 3.27929477 |
| 69 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.27353624 |
| 70 | oxidative phosphorylation (GO:0006119) | 3.26735069 |
| 71 | maturation of SSU-rRNA (GO:0030490) | 3.26579042 |
| 72 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.20110095 |
| 73 | protein localization to mitochondrion (GO:0070585) | 3.19686526 |
| 74 | DNA double-strand break processing (GO:0000729) | 3.18561103 |
| 75 | ribosomal small subunit biogenesis (GO:0042274) | 3.17671546 |
| 76 | rRNA metabolic process (GO:0016072) | 3.17218014 |
| 77 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.16771993 |
| 78 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.16552969 |
| 79 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.16552969 |
| 80 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.16552969 |
| 81 | DNA damage response, detection of DNA damage (GO:0042769) | 3.16160058 |
| 82 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.16150942 |
| 83 | cotranslational protein targeting to membrane (GO:0006613) | 3.15937831 |
| 84 | telomere maintenance via recombination (GO:0000722) | 3.14240688 |
| 85 | translational initiation (GO:0006413) | 3.13582472 |
| 86 | protein targeting to ER (GO:0045047) | 3.11268202 |
| 87 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.11092937 |
| 88 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.11092937 |
| 89 | mitotic spindle checkpoint (GO:0071174) | 3.10018815 |
| 90 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.08528393 |
| 91 | NADH dehydrogenase complex assembly (GO:0010257) | 3.08528393 |
| 92 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.08528393 |
| 93 | respiratory chain complex IV assembly (GO:0008535) | 3.08484087 |
| 94 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.08193385 |
| 95 | peptidyl-histidine modification (GO:0018202) | 3.07824768 |
| 96 | spindle checkpoint (GO:0031577) | 3.06746701 |
| 97 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.05996041 |
| 98 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.05996041 |
| 99 | positive regulation of ligase activity (GO:0051351) | 3.05266553 |
| 100 | translational elongation (GO:0006414) | 3.04559056 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.90322879 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.37582497 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.33709765 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.11048079 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.08749167 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.78355804 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.37656789 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.23767785 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.21972705 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.14627257 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.10437948 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.10367126 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.03984270 |
| 14 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.90889889 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.90666125 |
| 16 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.84217359 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.80298704 |
| 18 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.63796037 |
| 19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.49325304 |
| 20 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.38248655 |
| 21 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.35553873 |
| 22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.35021630 |
| 23 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.26825187 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.25023783 |
| 25 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.19067289 |
| 26 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.18345514 |
| 27 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.09738138 |
| 28 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.07051742 |
| 29 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.04699304 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.02395921 |
| 31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.91308651 |
| 32 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.88581050 |
| 33 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.86383284 |
| 34 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.85191102 |
| 35 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.72692201 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.70288521 |
| 37 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.69846251 |
| 38 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.67319383 |
| 39 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.67298176 |
| 40 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.67093483 |
| 41 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.65818920 |
| 42 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.64344795 |
| 43 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.62472742 |
| 44 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.59872714 |
| 45 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.58040440 |
| 46 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.57162974 |
| 47 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.55174827 |
| 48 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.54942761 |
| 49 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.49602416 |
| 50 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.48558755 |
| 51 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.46641844 |
| 52 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.44883890 |
| 53 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.44422044 |
| 54 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.44422044 |
| 55 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.44422044 |
| 56 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.42888204 |
| 57 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.41813702 |
| 58 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.40861155 |
| 59 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.34769032 |
| 60 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.28259889 |
| 61 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.27530357 |
| 62 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.24611164 |
| 63 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.24521520 |
| 64 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.22353105 |
| 65 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.21481451 |
| 66 | EWS_26573619_Chip-Seq_HEK293_Human | 1.19133887 |
| 67 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.10734304 |
| 68 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.09436092 |
| 69 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.08851914 |
| 70 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.03178455 |
| 71 | VDR_22108803_ChIP-Seq_LS180_Human | 1.00166486 |
| 72 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.97613230 |
| 73 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.96993095 |
| 74 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.96879203 |
| 75 | FUS_26573619_Chip-Seq_HEK293_Human | 0.95120217 |
| 76 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.94803081 |
| 77 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94279340 |
| 78 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.93808731 |
| 79 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.91954588 |
| 80 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.91872627 |
| 81 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.89346039 |
| 82 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.88727794 |
| 83 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.88643392 |
| 84 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.87417962 |
| 85 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.85952837 |
| 86 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.85848622 |
| 87 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.85787230 |
| 88 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.84401295 |
| 89 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.84071716 |
| 90 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.83079326 |
| 91 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.82323483 |
| 92 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.82296783 |
| 93 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.81958289 |
| 94 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.80979230 |
| 95 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.79695681 |
| 96 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.77321278 |
| 97 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.76569422 |
| 98 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.70583103 |
| 99 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.67390240 |
| 100 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.65259187 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 4.48198088 |
| 2 | MP0003941_abnormal_skin_development | 4.34480814 |
| 3 | MP0003693_abnormal_embryo_hatching | 4.28920039 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.99637299 |
| 5 | MP0006292_abnormal_olfactory_placode | 3.94881945 |
| 6 | MP0010094_abnormal_chromosome_stability | 3.80684330 |
| 7 | MP0003111_abnormal_nucleus_morphology | 3.59864581 |
| 8 | MP0003718_maternal_effect | 2.93318546 |
| 9 | MP0003077_abnormal_cell_cycle | 2.87578910 |
| 10 | MP0008877_abnormal_DNA_methylation | 2.81304422 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.75606373 |
| 12 | MP0008932_abnormal_embryonic_tissue | 2.57422497 |
| 13 | MP0009379_abnormal_foot_pigmentation | 2.56088752 |
| 14 | MP0008057_abnormal_DNA_replication | 2.41097509 |
| 15 | MP0002254_reproductive_system_inflammat | 2.23250204 |
| 16 | MP0001293_anophthalmia | 2.21323260 |
| 17 | MP0001188_hyperpigmentation | 1.98131293 |
| 18 | MP0006035_abnormal_mitochondrial_morpho | 1.92590543 |
| 19 | MP0006072_abnormal_retinal_apoptosis | 1.91216265 |
| 20 | MP0003186_abnormal_redox_activity | 1.88789004 |
| 21 | MP0003567_abnormal_fetal_cardiomyocyte | 1.78145562 |
| 22 | MP0006036_abnormal_mitochondrial_physio | 1.77716564 |
| 23 | MP0003786_premature_aging | 1.77585093 |
| 24 | MP0004133_heterotaxia | 1.73789249 |
| 25 | MP0001529_abnormal_vocalization | 1.73113295 |
| 26 | MP0003806_abnormal_nucleotide_metabolis | 1.70699081 |
| 27 | MP0003890_abnormal_embryonic-extraembry | 1.67473972 |
| 28 | MP0002736_abnormal_nociception_after | 1.64792268 |
| 29 | MP0003121_genomic_imprinting | 1.62975589 |
| 30 | MP0009672_abnormal_birth_weight | 1.59206136 |
| 31 | MP0000579_abnormal_nail_morphology | 1.56546655 |
| 32 | MP0003136_yellow_coat_color | 1.55829006 |
| 33 | MP0003195_calcinosis | 1.50832500 |
| 34 | MP0000350_abnormal_cell_proliferation | 1.47447792 |
| 35 | MP0003011_delayed_dark_adaptation | 1.46599516 |
| 36 | MP0001730_embryonic_growth_arrest | 1.42614140 |
| 37 | MP0009697_abnormal_copulation | 1.40753557 |
| 38 | MP0002277_abnormal_respiratory_mucosa | 1.31463567 |
| 39 | MP0002938_white_spotting | 1.20675537 |
| 40 | MP0003119_abnormal_digestive_system | 1.20146341 |
| 41 | MP0002751_abnormal_autonomic_nervous | 1.17784922 |
| 42 | MP0003937_abnormal_limbs/digits/tail_de | 1.17700122 |
| 43 | MP0008995_early_reproductive_senescence | 1.16399025 |
| 44 | MP0002102_abnormal_ear_morphology | 1.15955038 |
| 45 | MP0002085_abnormal_embryonic_tissue | 1.14814594 |
| 46 | MP0003787_abnormal_imprinting | 1.07283334 |
| 47 | MP0001485_abnormal_pinna_reflex | 1.04824655 |
| 48 | MP0001286_abnormal_eye_development | 1.04625095 |
| 49 | MP0000313_abnormal_cell_death | 1.04374286 |
| 50 | MP0001764_abnormal_homeostasis | 1.03383496 |
| 51 | MP0001697_abnormal_embryo_size | 1.03343921 |
| 52 | MP0005395_other_phenotype | 1.03039890 |
| 53 | MP0003283_abnormal_digestive_organ | 1.01899094 |
| 54 | MP0003122_maternal_imprinting | 1.00659978 |
| 55 | MP0001177_atelectasis | 1.00394478 |
| 56 | MP0002210_abnormal_sex_determination | 1.00213759 |
| 57 | MP0008789_abnormal_olfactory_epithelium | 0.96157596 |
| 58 | MP0000631_abnormal_neuroendocrine_gland | 0.95005410 |
| 59 | MP0002080_prenatal_lethality | 0.94903044 |
| 60 | MP0001672_abnormal_embryogenesis/_devel | 0.94758382 |
| 61 | MP0005380_embryogenesis_phenotype | 0.94758382 |
| 62 | MP0001145_abnormal_male_reproductive | 0.94007087 |
| 63 | MP0001968_abnormal_touch/_nociception | 0.93097427 |
| 64 | MP0001929_abnormal_gametogenesis | 0.92713379 |
| 65 | MP0005084_abnormal_gallbladder_morpholo | 0.92325746 |
| 66 | MP0000049_abnormal_middle_ear | 0.91336756 |
| 67 | MP0002233_abnormal_nose_morphology | 0.90743500 |
| 68 | MP0002697_abnormal_eye_size | 0.90705875 |
| 69 | MP0002084_abnormal_developmental_patter | 0.89702083 |
| 70 | MP0002160_abnormal_reproductive_system | 0.86609863 |
| 71 | MP0000653_abnormal_sex_gland | 0.86183405 |
| 72 | MP0005075_abnormal_melanosome_morpholog | 0.86033315 |
| 73 | MP0003123_paternal_imprinting | 0.85853308 |
| 74 | MP0002111_abnormal_tail_morphology | 0.85301426 |
| 75 | MP0003938_abnormal_ear_development | 0.84925247 |
| 76 | MP0004019_abnormal_vitamin_homeostasis | 0.82104246 |
| 77 | MP0002796_impaired_skin_barrier | 0.80471897 |
| 78 | MP0008872_abnormal_physiological_respon | 0.78188121 |
| 79 | MP0002282_abnormal_trachea_morphology | 0.77503170 |
| 80 | MP0000372_irregular_coat_pigmentation | 0.76893951 |
| 81 | MP0005645_abnormal_hypothalamus_physiol | 0.76668976 |
| 82 | MP0001984_abnormal_olfaction | 0.76250782 |
| 83 | MP0004215_abnormal_myocardial_fiber | 0.74336785 |
| 84 | MP0002396_abnormal_hematopoietic_system | 0.70969053 |
| 85 | MP0003984_embryonic_growth_retardation | 0.69990636 |
| 86 | MP0002088_abnormal_embryonic_growth/wei | 0.69348216 |
| 87 | MP0009703_decreased_birth_body | 0.67516289 |
| 88 | MP0005389_reproductive_system_phenotype | 0.66283317 |
| 89 | MP0004197_abnormal_fetal_growth/weight/ | 0.65490439 |
| 90 | MP0003698_abnormal_male_reproductive | 0.65304047 |
| 91 | MP0005551_abnormal_eye_electrophysiolog | 0.64284008 |
| 92 | MP0005253_abnormal_eye_physiology | 0.63895961 |
| 93 | MP0001727_abnormal_embryo_implantation | 0.61443550 |
| 94 | MP0010030_abnormal_orbit_morphology | 0.60481855 |
| 95 | MP0001119_abnormal_female_reproductive | 0.60286722 |
| 96 | MP0005377_hearing/vestibular/ear_phenot | 0.59800227 |
| 97 | MP0003878_abnormal_ear_physiology | 0.59800227 |
| 98 | MP0000678_abnormal_parathyroid_gland | 0.59784531 |
| 99 | MP0002019_abnormal_tumor_incidence | 0.59467470 |
| 100 | MP0000358_abnormal_cell_content/ | 0.59289842 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.04878584 |
| 2 | Acute encephalopathy (HP:0006846) | 4.53216176 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.41302178 |
| 4 | Increased hepatocellular lipid droplets (HP:0006565) | 4.24980774 |
| 5 | Mitochondrial inheritance (HP:0001427) | 4.14574438 |
| 6 | Progressive macrocephaly (HP:0004481) | 4.10301464 |
| 7 | Colon cancer (HP:0003003) | 3.94762918 |
| 8 | Increased CSF lactate (HP:0002490) | 3.72962239 |
| 9 | Lipid accumulation in hepatocytes (HP:0006561) | 3.72149453 |
| 10 | Cerebral edema (HP:0002181) | 3.66108044 |
| 11 | Abnormality of the labia minora (HP:0012880) | 3.64779753 |
| 12 | Abnormal number of erythroid precursors (HP:0012131) | 3.60221939 |
| 13 | Oral leukoplakia (HP:0002745) | 3.49946188 |
| 14 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.40213166 |
| 15 | Septo-optic dysplasia (HP:0100842) | 3.37792650 |
| 16 | Renal Fanconi syndrome (HP:0001994) | 3.36104162 |
| 17 | Aplastic anemia (HP:0001915) | 3.32165779 |
| 18 | Hepatocellular necrosis (HP:0001404) | 3.31813402 |
| 19 | Macrocytic anemia (HP:0001972) | 3.21169906 |
| 20 | Reticulocytopenia (HP:0001896) | 2.99260704 |
| 21 | Hyperglycinemia (HP:0002154) | 2.89122419 |
| 22 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.86495919 |
| 23 | Bilateral microphthalmos (HP:0007633) | 2.83878281 |
| 24 | Methylmalonic acidemia (HP:0002912) | 2.81829727 |
| 25 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.81551477 |
| 26 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.81551477 |
| 27 | Multiple enchondromatosis (HP:0005701) | 2.79361864 |
| 28 | Hepatic necrosis (HP:0002605) | 2.76903647 |
| 29 | Abnormality of serum amino acid levels (HP:0003112) | 2.75588807 |
| 30 | Birth length less than 3rd percentile (HP:0003561) | 2.73020693 |
| 31 | Abnormality of methionine metabolism (HP:0010901) | 2.72381290 |
| 32 | Meckel diverticulum (HP:0002245) | 2.63351976 |
| 33 | Leukodystrophy (HP:0002415) | 2.61577571 |
| 34 | Lactic acidosis (HP:0003128) | 2.58232695 |
| 35 | Methylmalonic aciduria (HP:0012120) | 2.56459333 |
| 36 | Exertional dyspnea (HP:0002875) | 2.53683809 |
| 37 | Increased intramyocellular lipid droplets (HP:0012240) | 2.51432960 |
| 38 | Hyperglycinuria (HP:0003108) | 2.51077411 |
| 39 | Abnormality of the ileum (HP:0001549) | 2.45299009 |
| 40 | Increased serum lactate (HP:0002151) | 2.45166016 |
| 41 | Respiratory failure (HP:0002878) | 2.44963289 |
| 42 | Abnormality of glycine metabolism (HP:0010895) | 2.44071655 |
| 43 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.44071655 |
| 44 | Abnormal number of incisors (HP:0011064) | 2.43299226 |
| 45 | Chromsome breakage (HP:0040012) | 2.42880652 |
| 46 | Megaloblastic anemia (HP:0001889) | 2.40460352 |
| 47 | Abnormality of homocysteine metabolism (HP:0010919) | 2.38738214 |
| 48 | Homocystinuria (HP:0002156) | 2.38738214 |
| 49 | Abnormal lung lobation (HP:0002101) | 2.38042807 |
| 50 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.37646366 |
| 51 | Microvesicular hepatic steatosis (HP:0001414) | 2.36218668 |
| 52 | Exercise intolerance (HP:0003546) | 2.33220428 |
| 53 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.32526509 |
| 54 | Pallor (HP:0000980) | 2.27119368 |
| 55 | Abnormality of renal resorption (HP:0011038) | 2.26810147 |
| 56 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.26593756 |
| 57 | Hypoglycemic seizures (HP:0002173) | 2.25658383 |
| 58 | Maternal diabetes (HP:0009800) | 2.20988253 |
| 59 | Respiratory difficulties (HP:0002880) | 2.20225441 |
| 60 | Abnormality of chromosome stability (HP:0003220) | 2.20147361 |
| 61 | Type I transferrin isoform profile (HP:0003642) | 2.14621001 |
| 62 | Congenital, generalized hypertrichosis (HP:0004540) | 2.14219544 |
| 63 | Absent septum pellucidum (HP:0001331) | 2.13296552 |
| 64 | Abnormality of the preputium (HP:0100587) | 2.13107918 |
| 65 | Cellular immunodeficiency (HP:0005374) | 2.12150858 |
| 66 | Lethargy (HP:0001254) | 2.09198362 |
| 67 | Ependymoma (HP:0002888) | 2.07570129 |
| 68 | Pendular nystagmus (HP:0012043) | 2.05878399 |
| 69 | Abnormality of the septum pellucidum (HP:0007375) | 2.03221129 |
| 70 | Optic disc pallor (HP:0000543) | 2.01061650 |
| 71 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.00965658 |
| 72 | Pancytopenia (HP:0001876) | 2.00477815 |
| 73 | Agnosia (HP:0010524) | 2.00013603 |
| 74 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.96065476 |
| 75 | Abolished electroretinogram (ERG) (HP:0000550) | 1.94649356 |
| 76 | Increased muscle lipid content (HP:0009058) | 1.94069445 |
| 77 | Small intestinal stenosis (HP:0012848) | 1.93069480 |
| 78 | Duodenal stenosis (HP:0100867) | 1.93069480 |
| 79 | Symptomatic seizures (HP:0011145) | 1.89865244 |
| 80 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.89417141 |
| 81 | Abnormality of alanine metabolism (HP:0010916) | 1.89417141 |
| 82 | Hyperalaninemia (HP:0003348) | 1.89417141 |
| 83 | Sparse eyelashes (HP:0000653) | 1.88705997 |
| 84 | Carpal bone hypoplasia (HP:0001498) | 1.88529620 |
| 85 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.88194950 |
| 86 | 3-Methylglutaconic aciduria (HP:0003535) | 1.88034306 |
| 87 | Rough bone trabeculation (HP:0100670) | 1.87587208 |
| 88 | Restlessness (HP:0000711) | 1.85690434 |
| 89 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.82446637 |
| 90 | Stenosis of the external auditory canal (HP:0000402) | 1.81957676 |
| 91 | Gonadotropin excess (HP:0000837) | 1.81507998 |
| 92 | X-linked dominant inheritance (HP:0001423) | 1.80748544 |
| 93 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.79381721 |
| 94 | Abnormality of the lacrimal duct (HP:0011481) | 1.79366182 |
| 95 | Selective tooth agenesis (HP:0001592) | 1.77157825 |
| 96 | Abnormality of the duodenum (HP:0002246) | 1.76689011 |
| 97 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.75706058 |
| 98 | Poor suck (HP:0002033) | 1.74839238 |
| 99 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.74693953 |
| 100 | Cleft eyelid (HP:0000625) | 1.73408715 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.33102711 |
| 2 | BUB1 | 4.67310726 |
| 3 | CDC7 | 4.54853521 |
| 4 | PBK | 3.77865914 |
| 5 | SRPK1 | 2.96199057 |
| 6 | STK16 | 2.81773970 |
| 7 | TTK | 2.66009314 |
| 8 | TNIK | 2.65726184 |
| 9 | ZAK | 2.63363609 |
| 10 | TAF1 | 2.57712193 |
| 11 | NME1 | 2.52458372 |
| 12 | VRK1 | 2.44022552 |
| 13 | PLK3 | 2.38339919 |
| 14 | MST4 | 2.31056063 |
| 15 | CDK19 | 2.30865288 |
| 16 | PLK4 | 2.25747401 |
| 17 | TSSK6 | 2.15158101 |
| 18 | NUAK1 | 2.11618198 |
| 19 | MKNK2 | 2.01866271 |
| 20 | NME2 | 1.97995526 |
| 21 | MKNK1 | 1.97411229 |
| 22 | DYRK2 | 1.69084304 |
| 23 | EIF2AK3 | 1.67130261 |
| 24 | PLK1 | 1.59132599 |
| 25 | NEK1 | 1.55776561 |
| 26 | DYRK3 | 1.40539141 |
| 27 | BCKDK | 1.30004120 |
| 28 | ACVR1B | 1.19381972 |
| 29 | WNK3 | 1.16517534 |
| 30 | BRSK2 | 1.13981537 |
| 31 | TRIM28 | 1.09684093 |
| 32 | EIF2AK1 | 1.08192037 |
| 33 | ALK | 1.02605351 |
| 34 | WEE1 | 0.99446698 |
| 35 | ATR | 0.97061907 |
| 36 | AURKB | 0.95693012 |
| 37 | PASK | 0.94610349 |
| 38 | OXSR1 | 0.94374620 |
| 39 | CHEK2 | 0.91871302 |
| 40 | BMPR1B | 0.90067970 |
| 41 | STK4 | 0.90053388 |
| 42 | CSNK1G1 | 0.84545498 |
| 43 | NLK | 0.81142773 |
| 44 | GRK1 | 0.79116697 |
| 45 | EIF2AK2 | 0.74079161 |
| 46 | AURKA | 0.72512565 |
| 47 | NEK2 | 0.72272466 |
| 48 | PNCK | 0.71563672 |
| 49 | CSNK1G2 | 0.65400649 |
| 50 | CSNK2A2 | 0.63306349 |
| 51 | CSNK2A1 | 0.63122069 |
| 52 | ATM | 0.62750491 |
| 53 | CDK7 | 0.62212655 |
| 54 | CHEK1 | 0.62102929 |
| 55 | STK38L | 0.60907096 |
| 56 | PDK2 | 0.60644587 |
| 57 | BRSK1 | 0.59873096 |
| 58 | CSNK1G3 | 0.58500069 |
| 59 | TIE1 | 0.57509966 |
| 60 | CDK3 | 0.56724364 |
| 61 | INSRR | 0.54091502 |
| 62 | KDR | 0.51487949 |
| 63 | PAK4 | 0.50034819 |
| 64 | TESK2 | 0.48684303 |
| 65 | CSNK1E | 0.44426542 |
| 66 | ADRBK2 | 0.41170318 |
| 67 | PRKDC | 0.41130594 |
| 68 | MAP4K2 | 0.40358959 |
| 69 | CDK2 | 0.39887677 |
| 70 | PLK2 | 0.39093374 |
| 71 | TEC | 0.38654637 |
| 72 | PRKCG | 0.38311415 |
| 73 | CDK1 | 0.38060722 |
| 74 | DAPK1 | 0.37688125 |
| 75 | RPS6KA4 | 0.35153681 |
| 76 | FGFR1 | 0.32895034 |
| 77 | PAK1 | 0.32721482 |
| 78 | CSNK1A1L | 0.30803164 |
| 79 | FLT3 | 0.30651814 |
| 80 | RPS6KA5 | 0.29916105 |
| 81 | CSNK1A1 | 0.27868750 |
| 82 | DYRK1A | 0.27797963 |
| 83 | TLK1 | 0.27330371 |
| 84 | ABL2 | 0.26005735 |
| 85 | SMG1 | 0.24221432 |
| 86 | STK24 | 0.23609635 |
| 87 | PIM1 | 0.22933796 |
| 88 | PRKG2 | 0.20659115 |
| 89 | STK3 | 0.19902391 |
| 90 | RPS6KA1 | 0.19881327 |
| 91 | UHMK1 | 0.17897104 |
| 92 | ERBB4 | 0.17224762 |
| 93 | PRKACB | 0.13760389 |
| 94 | MATK | 0.11588444 |
| 95 | CAMK1 | 0.11176773 |
| 96 | PRKCI | 0.11065194 |
| 97 | PINK1 | 0.10327889 |
| 98 | EGFR | 0.10179585 |
| 99 | MAP3K10 | 0.10077748 |
| 100 | TGFBR1 | 0.09539809 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.52026091 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 3.86628032 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 3.62217209 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.57077799 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.39903854 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.35423509 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 3.05982877 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.05418688 |
| 9 | Spliceosome_Homo sapiens_hsa03040 | 2.60039064 |
| 10 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.57514256 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.55489147 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.33276838 |
| 13 | Huntingtons disease_Homo sapiens_hsa05016 | 2.25395826 |
| 14 | Protein export_Homo sapiens_hsa03060 | 2.22760671 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 2.08629044 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.98369624 |
| 17 | Alzheimers disease_Homo sapiens_hsa05010 | 1.95693989 |
| 18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.88003574 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.86173432 |
| 20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.71333206 |
| 21 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.70816837 |
| 22 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.70504358 |
| 23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.62011811 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.56775435 |
| 25 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.55902111 |
| 26 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.51577308 |
| 27 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.49015087 |
| 28 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.48933217 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.43462212 |
| 30 | Cell cycle_Homo sapiens_hsa04110 | 1.40419294 |
| 31 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.36597876 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.33907693 |
| 33 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.31028802 |
| 34 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.26392535 |
| 35 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.23500613 |
| 36 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.18463692 |
| 37 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.12896574 |
| 38 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.07292699 |
| 39 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.07204967 |
| 40 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.05551252 |
| 41 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.01677428 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.01486970 |
| 43 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.99298722 |
| 44 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.98131493 |
| 45 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.91880209 |
| 46 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.90597401 |
| 47 | Carbon metabolism_Homo sapiens_hsa01200 | 0.89387938 |
| 48 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.80471169 |
| 49 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.72986405 |
| 50 | Metabolic pathways_Homo sapiens_hsa01100 | 0.72394276 |
| 51 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.69506468 |
| 52 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.67320699 |
| 53 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.56409369 |
| 54 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.54928783 |
| 55 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.50153425 |
| 56 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.49154671 |
| 57 | Sulfur relay system_Homo sapiens_hsa04122 | 0.48407067 |
| 58 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.46843286 |
| 59 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.46818799 |
| 60 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.45292056 |
| 61 | Peroxisome_Homo sapiens_hsa04146 | 0.45181481 |
| 62 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.44002769 |
| 63 | Retinol metabolism_Homo sapiens_hsa00830 | 0.43581688 |
| 64 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.42962751 |
| 65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.41808614 |
| 66 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41475703 |
| 67 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41264189 |
| 68 | Galactose metabolism_Homo sapiens_hsa00052 | 0.40642988 |
| 69 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.38227473 |
| 70 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.37522615 |
| 71 | Phototransduction_Homo sapiens_hsa04744 | 0.35602264 |
| 72 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.34198643 |
| 73 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.34076490 |
| 74 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.27909028 |
| 75 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.26645030 |
| 76 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.25662748 |
| 77 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.24692055 |
| 78 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.23229702 |
| 79 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.22587004 |
| 80 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.22130549 |
| 81 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21953581 |
| 82 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.21894925 |
| 83 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.21740034 |
| 84 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.19813345 |
| 85 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.19166655 |
| 86 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.18394006 |
| 87 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.18344996 |
| 88 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.18212692 |
| 89 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.17667939 |
| 90 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.17097095 |
| 91 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.15696320 |
| 92 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.15315268 |
| 93 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.14848943 |
| 94 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.14443900 |
| 95 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.13346144 |
| 96 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.11792717 |
| 97 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.10465609 |
| 98 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.10428886 |
| 99 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.08658224 |
| 100 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.08350629 |

