CRYGFP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.14353261
2chaperone-mediated protein transport (GO:0072321)5.92807520
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.32837284
4ATP synthesis coupled proton transport (GO:0015986)5.32837284
5rRNA modification (GO:0000154)5.14085565
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.09414050
7regulation of mitotic spindle checkpoint (GO:1903504)4.82396389
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.82396389
9proteasome assembly (GO:0043248)4.76521116
10spliceosomal snRNP assembly (GO:0000387)4.73054287
11somatic diversification of immune receptors via somatic mutation (GO:0002566)4.72940073
12somatic hypermutation of immunoglobulin genes (GO:0016446)4.72940073
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.72620328
14pseudouridine synthesis (GO:0001522)4.64321078
15establishment of integrated proviral latency (GO:0075713)4.43579185
16respiratory electron transport chain (GO:0022904)4.41133488
17electron transport chain (GO:0022900)4.30232313
18protein neddylation (GO:0045116)4.29334994
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.20158896
20ribosomal small subunit assembly (GO:0000028)4.17319846
21rRNA methylation (GO:0031167)4.07349349
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.06277369
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.06277369
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.06159229
25nucleobase biosynthetic process (GO:0046112)4.03954745
26protein complex biogenesis (GO:0070271)3.84730329
27NADH dehydrogenase complex assembly (GO:0010257)3.84613138
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84613138
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.84613138
30DNA deamination (GO:0045006)3.75774271
31ribosomal small subunit biogenesis (GO:0042274)3.73252954
32purine nucleobase biosynthetic process (GO:0009113)3.63509762
33mitochondrial respiratory chain complex assembly (GO:0033108)3.61432672
34viral transcription (GO:0019083)3.59803827
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59519053
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.59197896
37termination of RNA polymerase III transcription (GO:0006386)3.59197896
38oxidative phosphorylation (GO:0006119)3.58007577
39IMP biosynthetic process (GO:0006188)3.57309236
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.55387333
41translational termination (GO:0006415)3.49132713
42regulation of helicase activity (GO:0051095)3.47050755
43branched-chain amino acid catabolic process (GO:0009083)3.45608155
44IMP metabolic process (GO:0046040)3.42148058
45maturation of SSU-rRNA (GO:0030490)3.41051265
46mitochondrial RNA metabolic process (GO:0000959)3.38791160
47mannosylation (GO:0097502)3.33721814
48ribosome biogenesis (GO:0042254)3.33326380
49respiratory chain complex IV assembly (GO:0008535)3.32862979
50ribonucleoprotein complex biogenesis (GO:0022613)3.30867054
51negative regulation of ligase activity (GO:0051352)3.28628422
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28628422
53DNA replication checkpoint (GO:0000076)3.27074169
54cellular component biogenesis (GO:0044085)3.24824934
55ubiquinone biosynthetic process (GO:0006744)3.23675503
56chromatin remodeling at centromere (GO:0031055)3.23266888
57rRNA processing (GO:0006364)3.22087567
58translation (GO:0006412)3.21439605
59translational elongation (GO:0006414)3.21277684
60water-soluble vitamin biosynthetic process (GO:0042364)3.20131479
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19871755
62regulation of cellular amino acid metabolic process (GO:0006521)3.19863876
63establishment of viral latency (GO:0019043)3.18597214
64histone mRNA metabolic process (GO:0008334)3.16945272
65branched-chain amino acid metabolic process (GO:0009081)3.14268610
66inner mitochondrial membrane organization (GO:0007007)3.13386081
67rRNA metabolic process (GO:0016072)3.12000220
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09446257
69protein-cofactor linkage (GO:0018065)3.07837576
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05440868
71ATP biosynthetic process (GO:0006754)3.04887896
72ribosomal large subunit biogenesis (GO:0042273)3.04843995
73cotranslational protein targeting to membrane (GO:0006613)3.04092295
74CENP-A containing nucleosome assembly (GO:0034080)3.03686354
75cytochrome complex assembly (GO:0017004)3.02934581
76serine family amino acid catabolic process (GO:0009071)3.02243629
77protein targeting to ER (GO:0045047)3.01983919
78DNA damage response, detection of DNA damage (GO:0042769)2.94879692
79DNA ligation (GO:0006266)2.92612899
80termination of RNA polymerase II transcription (GO:0006369)2.90738543
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90735561
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90735561
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90735561
84aerobic respiration (GO:0009060)2.90433134
85peptidyl-arginine omega-N-methylation (GO:0035247)2.89353522
86translational initiation (GO:0006413)2.87642614
87hydrogen ion transmembrane transport (GO:1902600)2.87218212
88protein targeting to mitochondrion (GO:0006626)2.86563158
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86506127
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85170340
91DNA replication-dependent nucleosome assembly (GO:0006335)2.84402361
92DNA replication-dependent nucleosome organization (GO:0034723)2.84402361
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82953044
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82134468
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81342231
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81342231
97ubiquinone metabolic process (GO:0006743)2.80723791
98regulation of mitochondrial translation (GO:0070129)2.80659844
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.80579274
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80579274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human6.00079299
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.10118781
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.93652728
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.84046210
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.80195215
6E2F7_22180533_ChIP-Seq_HELA_Human3.60168383
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.54904792
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43462794
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.17975135
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.15278659
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.13785687
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.08716244
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.03383250
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89468710
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88049778
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75903083
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62295480
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61714787
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58268329
20FOXP3_21729870_ChIP-Seq_TREG_Human2.55114964
21VDR_23849224_ChIP-Seq_CD4+_Human2.46747996
22ELK1_19687146_ChIP-ChIP_HELA_Human2.43593086
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.41271510
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41020176
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25922297
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17113791
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04700641
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94191758
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.90095028
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88573193
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85777707
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85001467
33TTF2_22483619_ChIP-Seq_HELA_Human1.79932813
34XRN2_22483619_ChIP-Seq_HELA_Human1.76654764
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75159697
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72207034
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67728818
38ZNF274_21170338_ChIP-Seq_K562_Hela1.63496090
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56153437
40MYC_18940864_ChIP-ChIP_HL60_Human1.55003760
41DCP1A_22483619_ChIP-Seq_HELA_Human1.53445967
42GABP_19822575_ChIP-Seq_HepG2_Human1.50278143
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48688373
44CIITA_25753668_ChIP-Seq_RAJI_Human1.46422301
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44949350
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43239297
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41048954
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36864977
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36431599
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32814208
51EWS_26573619_Chip-Seq_HEK293_Human1.30911423
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27392810
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24892838
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20301609
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.19598913
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.19236261
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17612940
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17171443
59FUS_26573619_Chip-Seq_HEK293_Human1.13103012
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12146915
61VDR_22108803_ChIP-Seq_LS180_Human1.12146508
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.10081366
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.05049191
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04554860
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04313134
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02813673
67KDM5A_27292631_Chip-Seq_BREAST_Human1.01655172
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.01469994
69YY1_22570637_ChIP-Seq_MALME-3M_Human0.99358430
70MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98646925
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95441311
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95109202
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94670397
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89295737
75PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89130802
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87197160
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86783218
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86469884
79ELK1_22589737_ChIP-Seq_MCF10A_Human0.86226729
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85137668
81IGF1R_20145208_ChIP-Seq_DFB_Human0.85030873
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.85024866
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85024866
84NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83497203
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83054227
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82888727
87IRF8_22096565_ChIP-ChIP_GC-B_Human0.82592103
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82558167
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81237584
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78673730
91KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77904839
92RBPJ_21746931_ChIP-Seq_IB4_Human0.76980408
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.76536763
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76419642
95TP53_22573176_ChIP-Seq_HFKS_Human0.74261605
96AR_20517297_ChIP-Seq_VCAP_Human0.73538160
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71392879
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.69957991
99IRF1_19129219_ChIP-ChIP_H3396_Human0.69529228
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.69009563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.68418269
2MP0008058_abnormal_DNA_repair4.21042650
3MP0003123_paternal_imprinting3.16228954
4MP0003693_abnormal_embryo_hatching3.14926034
5MP0003195_calcinosis3.03448710
6MP0003718_maternal_effect2.96316816
7MP0004957_abnormal_blastocyst_morpholog2.80760518
8MP0003111_abnormal_nucleus_morphology2.78450908
9MP0005646_abnormal_pituitary_gland2.57091813
10MP0003941_abnormal_skin_development2.52269026
11MP0010094_abnormal_chromosome_stability2.50914397
12MP0001764_abnormal_homeostasis2.42566478
13MP0008007_abnormal_cellular_replicative2.23205967
14MP0003121_genomic_imprinting2.16240668
15MP0008877_abnormal_DNA_methylation2.12944941
16MP0009379_abnormal_foot_pigmentation2.12302634
17MP0010368_abnormal_lymphatic_system2.08586045
18MP0006292_abnormal_olfactory_placode2.04163854
19MP0002254_reproductive_system_inflammat1.92015646
20MP0009697_abnormal_copulation1.85515635
21MP0008875_abnormal_xenobiotic_pharmacok1.84345495
22MP0002277_abnormal_respiratory_mucosa1.83451371
23MP0006036_abnormal_mitochondrial_physio1.82942201
24MP0003724_increased_susceptibility_to1.81722191
25MP0003186_abnormal_redox_activity1.75106618
26MP0003786_premature_aging1.71414599
27MP0000372_irregular_coat_pigmentation1.70309723
28MP0005551_abnormal_eye_electrophysiolog1.68175916
29MP0008932_abnormal_embryonic_tissue1.64902686
30MP0005645_abnormal_hypothalamus_physiol1.61098336
31MP0005075_abnormal_melanosome_morpholog1.59420325
32MP0004147_increased_porphyrin_level1.55243615
33MP0003806_abnormal_nucleotide_metabolis1.44212924
34MP0002735_abnormal_chemical_nociception1.39019135
35MP0006072_abnormal_retinal_apoptosis1.38904510
36MP0002736_abnormal_nociception_after1.36880343
37MP0003077_abnormal_cell_cycle1.33412199
38MP0002837_dystrophic_cardiac_calcinosis1.32710049
39MP0001968_abnormal_touch/_nociception1.31676114
40MP0002148_abnormal_hypersensitivity_rea1.30554858
41MP0001293_anophthalmia1.26925202
42MP0008872_abnormal_physiological_respon1.26757350
43MP0006035_abnormal_mitochondrial_morpho1.25297485
44MP0008995_early_reproductive_senescence1.24183268
45MP0001529_abnormal_vocalization1.20752752
46MP0003638_abnormal_response/metabolism_1.15257374
47MP0005395_other_phenotype1.13990554
48MP0001905_abnormal_dopamine_level1.12519875
49MP0002396_abnormal_hematopoietic_system1.10263808
50MP0003880_abnormal_central_pattern1.10060799
51MP0010386_abnormal_urinary_bladder1.08631302
52MP0005332_abnormal_amino_acid1.08380896
53MP0003011_delayed_dark_adaptation1.07811454
54MP0008260_abnormal_autophagy1.05434100
55MP0002733_abnormal_thermal_nociception1.04586752
56MP0002282_abnormal_trachea_morphology1.03229759
57MP0001929_abnormal_gametogenesis1.00607088
58MP0002210_abnormal_sex_determination0.99735557
59MP0001485_abnormal_pinna_reflex0.94074483
60MP0002102_abnormal_ear_morphology0.93580211
61MP0002933_joint_inflammation0.92435718
62MP0000313_abnormal_cell_death0.90857837
63MP0002019_abnormal_tumor_incidence0.90736927
64MP0008873_increased_physiological_sensi0.90324117
65MP0001145_abnormal_male_reproductive0.87914178
66MP0002111_abnormal_tail_morphology0.86105995
67MP0000653_abnormal_sex_gland0.86038809
68MP0005253_abnormal_eye_physiology0.84624008
69MP0009765_abnormal_xenobiotic_induced0.84161221
70MP0005084_abnormal_gallbladder_morpholo0.81163953
71MP0000467_abnormal_esophagus_morphology0.80660678
72MP0000516_abnormal_urinary_system0.79696879
73MP0005367_renal/urinary_system_phenotyp0.79696879
74MP0001970_abnormal_pain_threshold0.78654160
75MP0009333_abnormal_splenocyte_physiolog0.78212146
76MP0001835_abnormal_antigen_presentation0.77202942
77MP0002160_abnormal_reproductive_system0.76845975
78MP0005220_abnormal_exocrine_pancreas0.74674624
79MP0006276_abnormal_autonomic_nervous0.74567696
80MP0003646_muscle_fatigue0.72729858
81MP0005636_abnormal_mineral_homeostasis0.72297265
82MP0001119_abnormal_female_reproductive0.72011708
83MP0009764_decreased_sensitivity_to0.71874013
84MP0000490_abnormal_crypts_of0.71243525
85MP0004043_abnormal_pH_regulation0.69436911
86MP0005310_abnormal_salivary_gland0.68511758
87MP0003137_abnormal_impulse_conducting0.67188574
88MP0003567_abnormal_fetal_cardiomyocyte0.67069280
89MP0002822_catalepsy0.66697347
90MP0001730_embryonic_growth_arrest0.66522619
91MP0003698_abnormal_male_reproductive0.65057514
92MP0000350_abnormal_cell_proliferation0.63710273
93MP0005389_reproductive_system_phenotype0.60957947
94MP0002938_white_spotting0.59813768
95MP0005000_abnormal_immune_tolerance0.59361916
96MP0000689_abnormal_spleen_morphology0.57435224
97MP0002398_abnormal_bone_marrow0.57209935
98MP0003866_abnormal_defecation0.56802866
99MP0001881_abnormal_mammary_gland0.55781146
100MP0008775_abnormal_heart_ventricle0.55407943

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.58888455
2Acute encephalopathy (HP:0006846)4.99563461
3Abnormal mitochondria in muscle tissue (HP:0008316)4.98351148
4Mitochondrial inheritance (HP:0001427)4.82722323
5Progressive macrocephaly (HP:0004481)4.61203189
6Increased hepatocellular lipid droplets (HP:0006565)4.39776369
7Increased CSF lactate (HP:0002490)4.20768753
8Cerebral edema (HP:0002181)4.12141928
9Hepatocellular necrosis (HP:0001404)3.99470289
10Lipid accumulation in hepatocytes (HP:0006561)3.91409875
113-Methylglutaconic aciduria (HP:0003535)3.75771808
12Hepatic necrosis (HP:0002605)3.71380972
13Aplastic anemia (HP:0001915)3.64342020
14Hyperglycinemia (HP:0002154)3.55004998
15Hyperglycinuria (HP:0003108)3.41537834
16Increased intramyocellular lipid droplets (HP:0012240)3.33138245
17Renal Fanconi syndrome (HP:0001994)3.31171947
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.29379613
19Colon cancer (HP:0003003)3.23429413
20Exertional dyspnea (HP:0002875)3.19316165
21Abnormality of glycine metabolism (HP:0010895)3.16105487
22Abnormality of serine family amino acid metabolism (HP:0010894)3.16105487
23Type 2 muscle fiber atrophy (HP:0003554)3.06403409
24Absent rod-and cone-mediated responses on ERG (HP:0007688)3.05589330
25Lactic acidosis (HP:0003128)3.03901674
26Type I transferrin isoform profile (HP:0003642)2.99786177
27Panhypogammaglobulinemia (HP:0003139)2.95069234
28Attenuation of retinal blood vessels (HP:0007843)2.94603115
29Abnormal number of erythroid precursors (HP:0012131)2.94478167
30Pancreatic fibrosis (HP:0100732)2.89839594
31Pancreatic cysts (HP:0001737)2.89756679
32Lethargy (HP:0001254)2.83575289
33Congenital stationary night blindness (HP:0007642)2.82081576
34Abnormality of serum amino acid levels (HP:0003112)2.81057786
35Optic disc pallor (HP:0000543)2.79790142
36Muscle fiber atrophy (HP:0100295)2.76963038
37Increased muscle lipid content (HP:0009058)2.74918238
38Respiratory failure (HP:0002878)2.69349547
39Decreased central vision (HP:0007663)2.68909758
40Generalized aminoaciduria (HP:0002909)2.66701753
41Increased serum lactate (HP:0002151)2.64531401
42Cerebellar dysplasia (HP:0007033)2.63895284
43True hermaphroditism (HP:0010459)2.60701298
44Oral leukoplakia (HP:0002745)2.59876128
45Macrocytic anemia (HP:0001972)2.59406435
46Abnormality of cells of the erythroid lineage (HP:0012130)2.58384093
47Exercise intolerance (HP:0003546)2.56025250
48Leukodystrophy (HP:0002415)2.53251995
49Occipital encephalocele (HP:0002085)2.47222800
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46995016
51Methylmalonic aciduria (HP:0012120)2.46614762
52Type II lissencephaly (HP:0007260)2.44800948
53Methylmalonic acidemia (HP:0002912)2.44388614
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43097433
55Abnormality of alanine metabolism (HP:0010916)2.43097433
56Hyperalaninemia (HP:0003348)2.43097433
57Abnormal protein glycosylation (HP:0012346)2.37564454
58Abnormal glycosylation (HP:0012345)2.37564454
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37564454
60Abnormal protein N-linked glycosylation (HP:0012347)2.37564454
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34170582
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34170582
63Megaloblastic anemia (HP:0001889)2.33362723
64Impulsivity (HP:0100710)2.30246509
65Abnormality of the labia minora (HP:0012880)2.28145421
66Abnormality of the ileum (HP:0001549)2.24796976
67Meckel diverticulum (HP:0002245)2.24043795
68Tinnitus (HP:0000360)2.22950344
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19729972
70Reduced antithrombin III activity (HP:0001976)2.07471215
71Severe visual impairment (HP:0001141)2.06401823
72Hyperphosphaturia (HP:0003109)2.06130845
73Hypothermia (HP:0002045)2.05305435
74Inability to walk (HP:0002540)2.04697646
75Hypoglycemic coma (HP:0001325)2.04507090
76Severe combined immunodeficiency (HP:0004430)2.03353912
77Respiratory difficulties (HP:0002880)2.03075667
78Abnormal rod and cone electroretinograms (HP:0008323)1.99749762
79Abnormality of urine glucose concentration (HP:0011016)1.96953297
80Glycosuria (HP:0003076)1.96953297
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96906814
82Dicarboxylic aciduria (HP:0003215)1.96906814
83Gonadal dysgenesis (HP:0000133)1.96362039
84Renal cortical cysts (HP:0000803)1.88314246
85Ketosis (HP:0001946)1.87745893
86Ketoacidosis (HP:0001993)1.87689784
87Abnormality of methionine metabolism (HP:0010901)1.87514152
88Abnormal lung lobation (HP:0002101)1.87506935
89Nausea (HP:0002018)1.84910779
90Abolished electroretinogram (ERG) (HP:0000550)1.84579624
91Abnormality of renal resorption (HP:0011038)1.84317711
92Abnormality of the preputium (HP:0100587)1.82371279
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80993880
94Combined immunodeficiency (HP:0005387)1.78235335
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.75647782
96Pancytopenia (HP:0001876)1.75297164
97Nephronophthisis (HP:0000090)1.73724967
98Anencephaly (HP:0002323)1.73277280
99Prostate neoplasm (HP:0100787)1.72994597
100Opisthotonus (HP:0002179)1.71833267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.88801110
2STK164.18006875
3ZAK3.96515560
4CDC73.41123510
5NUAK13.34824947
6BCKDK3.32856341
7BUB13.22668690
8MKNK13.20503964
9SRPK13.01148945
10PLK42.86893894
11TAF12.46854389
12NME22.42065840
13KDR2.33858681
14PBK2.31046584
15MAPKAPK52.14028974
16EIF2AK32.06780329
17VRK12.05852251
18NME11.75312146
19MAP4K21.73683850
20TNK21.69384978
21TTK1.64587324
22TIE11.64250772
23ADRBK21.50955078
24PLK31.49898304
25TEC1.34431363
26NEK11.34128467
27TNIK1.32501151
28TESK21.23475535
29EIF2AK21.18425645
30ALK1.17801574
31TSSK61.15058726
32BMX1.13776839
33BMPR1B1.12773986
34FLT31.09728646
35GRK11.08896260
36TAOK31.04057943
37RPS6KA51.02593935
38TXK1.01766322
39IRAK41.00258462
40CDK190.97947046
41WNK30.96999504
42FES0.96553879
43PLK10.93935975
44TLK10.89088323
45EIF2AK10.83122717
46KIT0.81798662
47CLK10.77193716
48ATR0.74995864
49CHEK20.73015021
50ACVR1B0.72883183
51NLK0.71384527
52PRKCQ0.70849714
53AURKB0.70363134
54BRSK20.63916775
55DYRK20.63481015
56SCYL20.63318387
57ITK0.60191350
58MARK30.57168135
59CDK70.56069673
60ADRBK10.55521792
61PASK0.54602854
62OXSR10.52529402
63STK40.51588377
64MKNK20.51442677
65DAPK10.50479287
66BCR0.50061129
67TAOK20.49482756
68MST40.47310018
69PIM10.46386934
70PIM20.45650566
71CSNK2A10.44847989
72IRAK10.44260983
73CSNK2A20.43415406
74FRK0.40220875
75LIMK10.37744920
76NEK20.37389343
77CSNK1G10.36118242
78WNK40.35310058
79INSRR0.33906179
80SMG10.33498697
81ATM0.31753993
82GRK50.30449227
83GRK60.30003379
84CSF1R0.29757177
85LYN0.26402398
86BRSK10.25828321
87ABL20.25168668
88ARAF0.24852899
89PRKCI0.24695859
90CSNK1A10.23584607
91PRKCG0.22759783
92SYK0.22706020
93CCNB10.21552962
94IKBKE0.21304561
95OBSCN0.19210640
96STK240.19124143
97PRKDC0.17443187
98LRRK20.16881763
99AURKA0.15621816
100PRKCA0.14581365

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.84709528
2Ribosome_Homo sapiens_hsa030103.83883807
3Oxidative phosphorylation_Homo sapiens_hsa001903.30345929
4RNA polymerase_Homo sapiens_hsa030202.98631740
5Parkinsons disease_Homo sapiens_hsa050122.97693837
6DNA replication_Homo sapiens_hsa030302.94192718
7One carbon pool by folate_Homo sapiens_hsa006702.88140016
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79828960
9Mismatch repair_Homo sapiens_hsa034302.73598211
10Non-homologous end-joining_Homo sapiens_hsa034502.45826463
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41077916
12Homologous recombination_Homo sapiens_hsa034402.14547100
13Spliceosome_Homo sapiens_hsa030402.06819177
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99546065
15Huntingtons disease_Homo sapiens_hsa050161.99101644
16Base excision repair_Homo sapiens_hsa034101.88927534
17Protein export_Homo sapiens_hsa030601.82305855
18Basal transcription factors_Homo sapiens_hsa030221.75865218
19Alzheimers disease_Homo sapiens_hsa050101.74909990
20RNA degradation_Homo sapiens_hsa030181.71676314
21Primary immunodeficiency_Homo sapiens_hsa053401.71665453
22Butanoate metabolism_Homo sapiens_hsa006501.70305213
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70255373
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69660879
25RNA transport_Homo sapiens_hsa030131.67271762
26Propanoate metabolism_Homo sapiens_hsa006401.62405030
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58146280
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.54920514
29Nucleotide excision repair_Homo sapiens_hsa034201.51640378
30Pyrimidine metabolism_Homo sapiens_hsa002401.47527626
31Phototransduction_Homo sapiens_hsa047441.34560433
32Purine metabolism_Homo sapiens_hsa002301.31655397
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27289061
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21375693
35Linoleic acid metabolism_Homo sapiens_hsa005911.21114648
36Cardiac muscle contraction_Homo sapiens_hsa042601.17579651
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17494444
38Fanconi anemia pathway_Homo sapiens_hsa034601.17233693
39Selenocompound metabolism_Homo sapiens_hsa004501.14620002
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13291557
41Sulfur metabolism_Homo sapiens_hsa009201.05085175
42Vitamin digestion and absorption_Homo sapiens_hsa049771.02511037
43Arachidonic acid metabolism_Homo sapiens_hsa005900.97868806
44Fatty acid elongation_Homo sapiens_hsa000620.90784859
45Phenylalanine metabolism_Homo sapiens_hsa003600.86428730
46Glutathione metabolism_Homo sapiens_hsa004800.86378574
47Tyrosine metabolism_Homo sapiens_hsa003500.86288572
48Pyruvate metabolism_Homo sapiens_hsa006200.86032930
49Biosynthesis of amino acids_Homo sapiens_hsa012300.84101822
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81941680
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81328541
52Carbon metabolism_Homo sapiens_hsa012000.79683608
53Metabolic pathways_Homo sapiens_hsa011000.78537342
54Peroxisome_Homo sapiens_hsa041460.77554006
55Tryptophan metabolism_Homo sapiens_hsa003800.74434037
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73959280
57Cell cycle_Homo sapiens_hsa041100.73173155
58beta-Alanine metabolism_Homo sapiens_hsa004100.70885598
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69744291
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.69566113
61Fatty acid degradation_Homo sapiens_hsa000710.68486898
62Retinol metabolism_Homo sapiens_hsa008300.65712999
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62596490
64mRNA surveillance pathway_Homo sapiens_hsa030150.62140946
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61997658
66Nitrogen metabolism_Homo sapiens_hsa009100.61756482
67Regulation of autophagy_Homo sapiens_hsa041400.60657745
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59824233
69Antigen processing and presentation_Homo sapiens_hsa046120.57741257
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.56153714
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55243360
72Vitamin B6 metabolism_Homo sapiens_hsa007500.54202238
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53385654
74Ether lipid metabolism_Homo sapiens_hsa005650.52930535
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52456409
76Fatty acid metabolism_Homo sapiens_hsa012120.52238001
77Chemical carcinogenesis_Homo sapiens_hsa052040.49367393
78Asthma_Homo sapiens_hsa053100.44051228
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.42235139
80Arginine and proline metabolism_Homo sapiens_hsa003300.42126908
81Ovarian steroidogenesis_Homo sapiens_hsa049130.41312669
82Graft-versus-host disease_Homo sapiens_hsa053320.40575885
83Autoimmune thyroid disease_Homo sapiens_hsa053200.39238241
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38322308
85Allograft rejection_Homo sapiens_hsa053300.37881470
86Taste transduction_Homo sapiens_hsa047420.37626106
87Type I diabetes mellitus_Homo sapiens_hsa049400.36885529
88Olfactory transduction_Homo sapiens_hsa047400.36508483
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35451320
90Systemic lupus erythematosus_Homo sapiens_hsa053220.34091633
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34002511
92Collecting duct acid secretion_Homo sapiens_hsa049660.29911467
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.27827032
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27676439
95Folate biosynthesis_Homo sapiens_hsa007900.25688407
96Steroid biosynthesis_Homo sapiens_hsa001000.24214587
97Epstein-Barr virus infection_Homo sapiens_hsa051690.23002789
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22779797
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20864730
100Histidine metabolism_Homo sapiens_hsa003400.20812415

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