CRYGN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to muscle activity (GO:0014850)9.62684505
2thyroid hormone generation (GO:0006590)8.98665382
3visual perception (GO:0007601)8.51017222
4sensory perception of light stimulus (GO:0050953)8.42069684
5cytolysis (GO:0019835)8.20280674
6camera-type eye development (GO:0043010)7.94496260
7thyroid hormone metabolic process (GO:0042403)7.64101314
8protein refolding (GO:0042026)7.53614313
9muscle cell cellular homeostasis (GO:0046716)7.07929050
10retinal cone cell development (GO:0046549)6.93047364
11regulation of protein sumoylation (GO:0033233)6.91710955
12bile acid and bile salt transport (GO:0015721)6.89729326
13histone H3-K9 demethylation (GO:0033169)6.66915997
14eye development (GO:0001654)6.57948088
15central nervous system myelination (GO:0022010)6.14127072
16axon ensheathment in central nervous system (GO:0032291)6.14127072
17cellular response to osmotic stress (GO:0071470)6.01100513
18myofibril assembly (GO:0030239)5.95055505
19gamma-aminobutyric acid transport (GO:0015812)5.64144994
20negative regulation of oligodendrocyte differentiation (GO:0048715)5.41328179
21regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.35063015
22regulation of ER to Golgi vesicle-mediated transport (GO:0060628)5.25056468
23sensory organ development (GO:0007423)5.01974411
24atrioventricular valve morphogenesis (GO:0003181)4.75486326
25pericardium development (GO:0060039)4.70873345
26positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)4.55534996
27regulation of type B pancreatic cell apoptotic process (GO:2000674)4.54927554
28keratan sulfate catabolic process (GO:0042340)4.51990520
29metanephric epithelium development (GO:0072207)4.51903026
30negative regulation of homotypic cell-cell adhesion (GO:0034111)4.51857897
31mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.50086443
32response to salt stress (GO:0009651)4.49908795
33negative regulation of astrocyte differentiation (GO:0048712)4.44960047
34sarcomere organization (GO:0045214)4.24389001
35cilium movement (GO:0003341)4.21597383
36cell wall macromolecule catabolic process (GO:0016998)4.09339549
37lens development in camera-type eye (GO:0002088)34.4723329
38pattern specification involved in kidney development (GO:0061004)3.97183860
39atrial septum morphogenesis (GO:0060413)3.95230292
40regulation of cardioblast proliferation (GO:0003264)3.93266949
41regulation of secondary heart field cardioblast proliferation (GO:0003266)3.93266949
42insulin-like growth factor receptor signaling pathway (GO:0048009)3.92776499
43regulation of myoblast differentiation (GO:0045661)3.92352664
44sensory perception (GO:0007600)3.90937682
45regulation of beta-amyloid formation (GO:1902003)3.90193646
46histone H4-K12 acetylation (GO:0043983)3.90187287
47lung epithelium development (GO:0060428)3.87284221
48regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.85610070
49sulfate transport (GO:0008272)3.69579016
50protein homotrimerization (GO:0070207)3.68320538
51sulfate transmembrane transport (GO:1902358)3.66990074
52response to pheromone (GO:0019236)3.66779378
53intestinal epithelial cell development (GO:0060576)3.63273095
54regulation of cardioblast differentiation (GO:0051890)3.60686521
55urinary tract smooth muscle contraction (GO:0014848)3.57941038
56SMAD protein complex assembly (GO:0007183)3.57423441
57regulation of non-canonical Wnt signaling pathway (GO:2000050)3.57164186
58neuroblast proliferation (GO:0007405)3.56467861
59cerebral cortex neuron differentiation (GO:0021895)3.55565780
60negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.54364520
61positive regulation of cellular amide metabolic process (GO:0034250)3.46848727
62positive regulation of dendritic spine morphogenesis (GO:0061003)3.38484927
63GTP biosynthetic process (GO:0006183)3.36325658
64cell wall macromolecule metabolic process (GO:0044036)3.35073431
65regulation of hippo signaling (GO:0035330)3.34855131
66regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.34442445
67kidney morphogenesis (GO:0060993)3.33638730
68regulation of hexokinase activity (GO:1903299)3.33000259
69regulation of glucokinase activity (GO:0033131)3.33000259
70nucleotide transmembrane transport (GO:1901679)3.29870687
71axoneme assembly (GO:0035082)3.24762031
72mesenchymal to epithelial transition (GO:0060231)3.24517876
73anterior/posterior axis specification, embryo (GO:0008595)3.22585122
74regulation of steroid hormone biosynthetic process (GO:0090030)3.21761046
75metanephric mesenchyme development (GO:0072075)3.21024175
76regulation of glucocorticoid metabolic process (GO:0031943)3.19648935
77thyroid gland development (GO:0030878)3.18832898
78lateral sprouting from an epithelium (GO:0060601)3.16475758
79nephron tubule formation (GO:0072079)3.15757146
80collagen fibril organization (GO:0030199)3.14878911
81positive regulation of wound healing (GO:0090303)3.14540359
82protein-cofactor linkage (GO:0018065)3.12158310
83signal peptide processing (GO:0006465)3.10940465
84cellular ketone body metabolic process (GO:0046950)3.10531942
85water transport (GO:0006833)3.09533632
86negative regulation of organ growth (GO:0046621)3.07475698
87ventricular system development (GO:0021591)3.07438399
88neuromuscular process controlling posture (GO:0050884)3.07042206
89UTP biosynthetic process (GO:0006228)3.06112677
90regulation of platelet aggregation (GO:0090330)3.05970945
91cellular response to calcium ion (GO:0071277)3.03962762
92regulation of skeletal muscle fiber development (GO:0048742)3.03955856
93establishment of planar polarity (GO:0001736)3.03546978
94establishment of tissue polarity (GO:0007164)3.03546978
95axonemal dynein complex assembly (GO:0070286)3.03286436
96UTP metabolic process (GO:0046051)3.01573196
97lens fiber cell development (GO:0070307)25.1125273
98cell migration involved in heart development (GO:0060973)2.99232606
99regulation of glucose import in response to insulin stimulus (GO:2001273)2.98519730
100regulation of Rac protein signal transduction (GO:0035020)2.96898386
101negative regulation of gluconeogenesis (GO:0045721)2.95596764
102peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.95409762
103negative regulation of platelet activation (GO:0010544)2.90878087
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88803574
105regulation of oligodendrocyte differentiation (GO:0048713)2.87963791
106epithelial cilium movement (GO:0003351)2.87022991
107photoreceptor cell development (GO:0042461)2.86940981
108positive regulation of osteoblast proliferation (GO:0033690)2.85399531
109cardiac right ventricle morphogenesis (GO:0003215)2.85356829
110negative regulation of telomere maintenance (GO:0032205)2.84024578
111negative regulation of glial cell differentiation (GO:0045686)2.83276250
112cGMP-mediated signaling (GO:0019934)2.82167822
113positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.81412406
114negative regulation of heart growth (GO:0061117)2.79302560
115negative regulation of cardiac muscle tissue growth (GO:0055022)2.79302560
116L-serine transport (GO:0015825)2.78787994
117positive regulation of calcium ion transport into cytosol (GO:0010524)2.78474370
118zinc ion transport (GO:0006829)2.77190889
119negative regulation of epithelial to mesenchymal transition (GO:0010719)2.76217429
120regulation of protein polyubiquitination (GO:1902914)2.75935559
121regulation of endothelial cell chemotaxis (GO:2001026)2.75452046
122inner ear receptor stereocilium organization (GO:0060122)2.72408163
123ventricular septum development (GO:0003281)2.72105089
124transepithelial transport (GO:0070633)2.71610572
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.71080664
126zinc ion homeostasis (GO:0055069)2.69942305
127renal tubule development (GO:0061326)2.67602743
128negative regulation of fat cell differentiation (GO:0045599)2.66583161
129cellular response to ATP (GO:0071318)2.66357453
130fluid transport (GO:0042044)2.66137615
131ketone body metabolic process (GO:1902224)2.65944391
132serine transport (GO:0032329)2.65070951
133mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.63595862
134positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.63595862
135regulation of mesenchymal cell apoptotic process (GO:2001053)2.63569210
136kinetochore assembly (GO:0051382)2.63059909
137lung-associated mesenchyme development (GO:0060484)2.60666092
138intermediate filament cytoskeleton organization (GO:0045104)2.59365246
139epithelial cell development (GO:0002064)2.54085689
140response to activity (GO:0014823)2.53862047
141intermediate filament-based process (GO:0045103)2.47075762
142nucleoside diphosphate phosphorylation (GO:0006165)2.45895924
143cerebellar granule cell differentiation (GO:0021707)2.42082535
144regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.36789996
145skeletal muscle organ development (GO:0060538)2.33357077
146left/right axis specification (GO:0070986)2.31178361
147actomyosin structure organization (GO:0031032)2.29475552
148respiratory tube development (GO:0030323)2.21274791
149regulation of myotube differentiation (GO:0010830)2.19493700
150dopaminergic neuron differentiation (GO:0071542)2.19253520
151cartilage morphogenesis (GO:0060536)2.18953217
152protein localization to cell surface (GO:0034394)2.17793743
153low-density lipoprotein particle remodeling (GO:0034374)2.17488633
154activation of JUN kinase activity (GO:0007257)2.15697627
155mating behavior (GO:0007617)2.14589663
156positive regulation of dendritic spine development (GO:0060999)2.09785981
157diaphragm development (GO:0060539)2.09228149
158histone lysine demethylation (GO:0070076)2.08130341
159CTP metabolic process (GO:0046036)2.04985098
160CTP biosynthetic process (GO:0006241)2.04985098
161basement membrane organization (GO:0071711)2.04596657
162negative regulation of hormone biosynthetic process (GO:0032353)2.03977917
163negative regulation of hormone metabolic process (GO:0032351)2.03977917
164response to osmotic stress (GO:0006970)2.03876398
165erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.02693461
166L-phenylalanine catabolic process (GO:0006559)2.02693461
167cilium or flagellum-dependent cell motility (GO:0001539)2.01314997
168lens fiber cell differentiation (GO:0070306)19.8858010
169lens morphogenesis in camera-type eye (GO:0002089)10.3062039
170cell-cell junction assembly (GO:0007043)1.99432759
171regulation of release of sequestered calcium ion into cytosol (GO:0051279)1.97337992
172embryonic retina morphogenesis in camera-type eye (GO:0060059)1.96157114
173pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)1.95338322
174metanephric tubule development (GO:0072170)1.95204245
175metanephric nephron tubule development (GO:0072234)1.95204245
176histone demethylation (GO:0016577)1.94456200
177epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)1.94315683
178L-alpha-amino acid transmembrane transport (GO:1902475)1.91833349
179pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)1.91584950
180prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060521.90684746
181guanosine-containing compound biosynthetic process (GO:1901070)1.90572488
182erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.90121246
183L-phenylalanine metabolic process (GO:0006558)1.90121246
184carnitine shuttle (GO:0006853)1.88378516
185positive regulation of cellular response to insulin stimulus (GO:1900078)1.87041020
186neuronal stem cell maintenance (GO:0097150)1.82681119
187regulation of striated muscle cell differentiation (GO:0051153)1.79894892
188regulation of fatty acid beta-oxidation (GO:0031998)1.79813599
189regulation of homotypic cell-cell adhesion (GO:0034110)1.79197960
190glyoxylate metabolic process (GO:0046487)1.77247011
191metanephric nephron epithelium development (GO:0072243)1.76786820
192protein trimerization (GO:0070206)1.74237136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.53312124
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.73556083
3PCGF2_27294783_Chip-Seq_NPCs_Mouse3.38078221
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.03436172
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.96839864
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.86070361
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84829918
8EGR1_19032775_ChIP-ChIP_M12_Human2.74470895
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68943055
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57510179
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.45471803
12GBX2_23144817_ChIP-Seq_PC3_Human2.44089798
13BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.43865916
14P300_19829295_ChIP-Seq_ESCs_Human2.43729013
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.32564235
16IGF1R_20145208_ChIP-Seq_DFB_Human2.29643631
17BCAT_22108803_ChIP-Seq_LS180_Human2.23229472
18FUS_26573619_Chip-Seq_HEK293_Human2.21919358
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16545288
20NFE2_27457419_Chip-Seq_LIVER_Mouse2.16410250
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.13267761
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12461089
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07926348
24SUZ12_27294783_Chip-Seq_NPCs_Mouse2.05897954
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.01144567
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse10.4286555
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97293780
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96255575
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95609948
30EWS_26573619_Chip-Seq_HEK293_Human1.90044136
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87782943
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87782943
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.87538755
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86117950
35AR_25329375_ChIP-Seq_VCAP_Human1.84203742
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83405450
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.82157946
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.82157946
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.82157946
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.78149661
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77678718
42GATA1_22025678_ChIP-Seq_K562_Human1.75452673
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.72747678
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.71196724
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.68953573
46AR_21572438_ChIP-Seq_LNCaP_Human1.68719626
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67921777
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64384605
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.63516180
50GATA3_24758297_ChIP-Seq_MCF-7_Human1.62632176
51SMAD3_21741376_ChIP-Seq_HESCs_Human1.62532612
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58707297
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57205657
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56866082
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55109898
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.54810568
57* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52715841
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51314338
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.51215608
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47352826
61CTCF_18555785_Chip-Seq_ESCs_Mouse1.43598384
62SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43403657
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42160091
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42022799
65ER_23166858_ChIP-Seq_MCF-7_Human1.39952153
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39157326
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39101831
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.39051478
69TCF4_22108803_ChIP-Seq_LS180_Human1.37118273
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.36700812
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35397074
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35387449
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34438804
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34120130
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.34019985
76* RUNX2_22187159_ChIP-Seq_PCA_Human1.33532243
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32426091
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.31822029
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31099474
80* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30954952
81PU1_27457419_Chip-Seq_LIVER_Mouse1.30900081
82CDX2_22108803_ChIP-Seq_LS180_Human1.30490797
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30029025
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28205322
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28043003
86JUN_21703547_ChIP-Seq_K562_Human1.26934327
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26401010
88SMAD4_21799915_ChIP-Seq_A2780_Human1.26118160
89SMC3_22415368_ChIP-Seq_MEFs_Mouse1.26018680
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25610282
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.25267682
92RNF2_27304074_Chip-Seq_NSC_Mouse1.24921107
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24380800
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24215524
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.23673592
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23029996
97REST_21632747_ChIP-Seq_MESCs_Mouse1.20841528
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20221585
99SALL4_22934838_ChIP-ChIP_CD34+_Human1.20037362
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19922515
101EZH2_22144423_ChIP-Seq_EOC_Human1.19894970
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19431561
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19262368
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19262368
105TP53_22573176_ChIP-Seq_HFKS_Human1.19188457
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16848938
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16524173
108* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16514415
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.16198503
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15362791
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.15362791
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15158434
113SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14760873
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.14506996
115SOX9_26525672_Chip-Seq_HEART_Mouse1.14079446
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.13962015
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13913529
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.13859855
119GATA3_21878914_ChIP-Seq_MCF-7_Human1.13581161
120CLOCK_20551151_ChIP-Seq_293T_Human1.13485558
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13304910
122VDR_22108803_ChIP-Seq_LS180_Human1.12954855
123* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11192437
124CTCF_27219007_Chip-Seq_Bcells_Human1.11129745
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11020070
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10025876
127P53_22387025_ChIP-Seq_ESCs_Mouse1.08364899
128LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08248559
129FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07324142
130GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07151784
131OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07021170
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07007204
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06856068
134FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03990290
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03534030
136NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03068045
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02114771
138ZNF274_21170338_ChIP-Seq_K562_Hela1.01286271
139SOX2_18555785_Chip-Seq_ESCs_Mouse1.01262575
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01023154
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.00846752
142ZFX_18555785_Chip-Seq_ESCs_Mouse1.00532226
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99494767
144PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99325437
145DROSHA_22980978_ChIP-Seq_HELA_Human0.99037145
146SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98996776
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98876401
148TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98858713
149TCF4_23295773_ChIP-Seq_U87_Human0.98857121
150PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98735064
151SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98587432
152AR_20517297_ChIP-Seq_VCAP_Human0.98196735
153PRDM14_20953172_ChIP-Seq_ESCs_Human0.98050655
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97832471
155FOXA2_19822575_ChIP-Seq_HepG2_Human0.97584744
156AHR_22903824_ChIP-Seq_MCF-7_Human0.97494655
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96962423
158SMAD3_21741376_ChIP-Seq_ESCs_Human0.96793407
159SOX2_16153702_ChIP-ChIP_HESCs_Human0.96769962
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96620631
161KLF4_18555785_Chip-Seq_ESCs_Mouse0.96316116
162STAT3_23295773_ChIP-Seq_U87_Human0.96285134
163SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94242531
164EGR1_19374776_ChIP-ChIP_THP-1_Human0.93843664
165ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89956128
166SMAD3_21741376_ChIP-Seq_EPCs_Human0.88246183
167TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88223715
168RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88158730
169PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87947269
170RXR_22158963_ChIP-Seq_LIVER_Mouse0.85647190
171P300_18555785_Chip-Seq_ESCs_Mouse0.85517090
172LXR_22292898_ChIP-Seq_THP-1_Human0.85506531
173NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85482976
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84940500
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84318350
176SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84048613
177GATA2_21666600_ChIP-Seq_HMVEC_Human0.83253754
178SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82436753
179ZNF263_19887448_ChIP-Seq_K562_Human0.81994525
180LXR_22158963_ChIP-Seq_LIVER_Mouse0.81641672
181* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81568378
182P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79185214
183SMC1_22415368_ChIP-Seq_MEFs_Mouse0.78340069
184ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78161439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005193_abnormal_anterior_eye9.00657078
2MP0003283_abnormal_digestive_organ7.05181894
3MP0005503_abnormal_tendon_morphology5.78890162
4MP0005253_abnormal_eye_physiology4.66409224
5MP0001286_abnormal_eye_development3.85669407
6MP0000749_muscle_degeneration3.77707228
7MP0002092_abnormal_eye_morphology3.71186061
8MP0005197_abnormal_uvea_morphology3.60932299
9MP0002876_abnormal_thyroid_physiology3.60630682
10MP0002254_reproductive_system_inflammat3.49616354
11MP0000681_abnormal_thyroid_gland3.31698780
12MP0005391_vision/eye_phenotype3.06001459
13MP0003941_abnormal_skin_development2.95662726
14MP0005275_abnormal_skin_tensile2.73153076
15MP0000383_abnormal_hair_follicle2.39733914
16MP0002102_abnormal_ear_morphology2.29414807
17MP0001348_abnormal_lacrimal_gland2.25788227
18MP0002090_abnormal_vision2.24647147
19MP0003195_calcinosis2.21430617
20MP0009384_cardiac_valve_regurgitation2.14801450
21MP0000462_abnormal_digestive_system2.14488707
22MP0001346_abnormal_lacrimal_gland2.02741646
23MP0002697_abnormal_eye_size13.9069064
24MP0001984_abnormal_olfaction1.96489592
25MP0005645_abnormal_hypothalamus_physiol1.83455159
26MP0004742_abnormal_vestibular_system1.78175148
27MP0008877_abnormal_DNA_methylation1.73099741
28MP0005508_abnormal_skeleton_morphology1.70100445
29MP0004133_heterotaxia1.64788289
30MP0010678_abnormal_skin_adnexa1.64627651
31MP0002139_abnormal_hepatobiliary_system1.63706243
32MP0001485_abnormal_pinna_reflex1.63189202
33MP0010368_abnormal_lymphatic_system1.58385392
34MP0008995_early_reproductive_senescence1.58324079
35MP0002108_abnormal_muscle_morphology1.57988049
36MP0005257_abnormal_intraocular_pressure1.56625688
37MP0004272_abnormal_basement_membrane1.55609183
38MP0005379_endocrine/exocrine_gland_phen1.50961299
39MP0004043_abnormal_pH_regulation1.48440885
40MP0003119_abnormal_digestive_system1.45148333
41MP0005330_cardiomyopathy1.44803832
42MP0002638_abnormal_pupillary_reflex1.43553792
43MP0002269_muscular_atrophy1.33465932
44MP0005167_abnormal_blood-brain_barrier1.28221211
45MP0001502_abnormal_circadian_rhythm1.26987811
46MP0003279_aneurysm1.25906331
47MP0000026_abnormal_inner_ear1.25820861
48MP0005171_absent_coat_pigmentation1.18593774
49MP0005360_urolithiasis1.14357748
50MP0005174_abnormal_tail_pigmentation1.14127434
51MP0005085_abnormal_gallbladder_physiolo1.08712497
52MP0010030_abnormal_orbit_morphology1.08490729
53MP0004142_abnormal_muscle_tone1.07457390
54MP0002735_abnormal_chemical_nociception1.05988747
55MP0001501_abnormal_sleep_pattern1.02482666
56MP0000631_abnormal_neuroendocrine_gland0.98711012
57MP0002272_abnormal_nervous_system0.98373324
58MP0005195_abnormal_posterior_eye0.98122858
59MP0005319_abnormal_enzyme/_coenzyme0.95169370
60MP0001293_anophthalmia0.90409345
61MP0003937_abnormal_limbs/digits/tail_de0.89669271
62MP0002249_abnormal_larynx_morphology0.89286389
63MP0001340_abnormal_eyelid_morphology0.88333610
64MP0001963_abnormal_hearing_physiology0.88136596
65MP0002653_abnormal_ependyma_morphology0.86963970
66MP0003252_abnormal_bile_duct0.86546763
67MP0005623_abnormal_meninges_morphology0.86127904
68MP0003936_abnormal_reproductive_system0.85473797
69MP0002111_abnormal_tail_morphology0.83196158
70MP0000427_abnormal_hair_cycle0.82243778
71MP0002736_abnormal_nociception_after0.81392524
72MP0000049_abnormal_middle_ear0.81242467
73MP0005410_abnormal_fertilization0.79975932
74MP0001299_abnormal_eye_distance/0.79676138
75MP0003705_abnormal_hypodermis_morpholog0.77999379
76MP0003136_yellow_coat_color0.77021196
77MP0002896_abnormal_bone_mineralization0.76744510
78MP0003137_abnormal_impulse_conducting0.76369927
79MP0003938_abnormal_ear_development0.76136600
80MP0006292_abnormal_olfactory_placode0.76094176
81MP0008569_lethality_at_weaning0.74031849
82MP0009745_abnormal_behavioral_response0.71196194
83MP0004019_abnormal_vitamin_homeostasis0.71186527
84MP0005551_abnormal_eye_electrophysiolog0.70845265
85MP0002751_abnormal_autonomic_nervous0.70628181
86MP0001243_abnormal_dermal_layer0.70524694
87MP0008004_abnormal_stomach_pH0.69613981
88MP0009046_muscle_twitch0.69272304
89MP0000013_abnormal_adipose_tissue0.68832735
90MP0008438_abnormal_cutaneous_collagen0.67966720
91MP0004147_increased_porphyrin_level0.67055176
92MP0009379_abnormal_foot_pigmentation0.66197279
93MP0005365_abnormal_bile_salt0.64835789
94MP0002229_neurodegeneration0.64513720
95MP0002938_white_spotting0.63822862
96MP0004087_abnormal_muscle_fiber0.63371601
97MP0001879_abnormal_lymphatic_vessel0.63075851
98MP0001944_abnormal_pancreas_morphology0.62881495
99MP0001905_abnormal_dopamine_level0.62490144
100MP0005390_skeleton_phenotype0.62341361
101MP0002909_abnormal_adrenal_gland0.61262179
102MP0000639_abnormal_adrenal_gland0.61025957
103MP0003698_abnormal_male_reproductive0.60674198
104MP0002089_abnormal_postnatal_growth/wei0.60454127
105MP0005164_abnormal_response_to0.58482678
106MP0002109_abnormal_limb_morphology0.57744080
107MP0002837_dystrophic_cardiac_calcinosis0.56255039
108MP0000470_abnormal_stomach_morphology0.55183463
109MP0005369_muscle_phenotype0.54874135
110MP0008875_abnormal_xenobiotic_pharmacok0.54377336
111MP0003878_abnormal_ear_physiology0.53917169
112MP0005377_hearing/vestibular/ear_phenot0.53917169
113MP0005023_abnormal_wound_healing0.53864110
114MP0001968_abnormal_touch/_nociception0.53806114
115MP0003890_abnormal_embryonic-extraembry0.53713786
116MP0009703_decreased_birth_body0.51633281
117MP0000762_abnormal_tongue_morphology0.50773068
118MP0005647_abnormal_sex_gland0.50488775
119MP0000163_abnormal_cartilage_morphology0.49428477
120MP0003656_abnormal_erythrocyte_physiolo0.49363402
121MP0002734_abnormal_mechanical_nocicepti0.46488952
122MP0009250_abnormal_appendicular_skeleto0.46093447
123MP0009780_abnormal_chondrocyte_physiolo0.45221930
124MP0005248_abnormal_Harderian_gland0.45038741
125MP0002282_abnormal_trachea_morphology0.44684347
126MP0003123_paternal_imprinting0.44522439
127MP0010329_abnormal_lipoprotein_level0.44278166
128MP0003329_amyloid_beta_deposits0.42538893
129MP0000759_abnormal_skeletal_muscle0.41747829
130MP0003942_abnormal_urinary_system0.40673465
131MP0004859_abnormal_synaptic_plasticity0.39861765
132MP0009053_abnormal_anal_canal0.39470637
133MP0005187_abnormal_penis_morphology0.39312369
134MP0000428_abnormal_craniofacial_morphol0.39231255
135MP0003690_abnormal_glial_cell0.37902829
136MP0000747_muscle_weakness0.34712381
137MP0004858_abnormal_nervous_system0.33221202
138MP0002295_abnormal_pulmonary_circulatio0.32164856
139MP0002177_abnormal_outer_ear0.31713803
140MP0003635_abnormal_synaptic_transmissio0.29977429
141MP0003566_abnormal_cell_adhesion0.29531859
142MP0001915_intracranial_hemorrhage0.29236044
143MP0001943_abnormal_respiration0.28613869
144MP0002928_abnormal_bile_duct0.28523599
145MP0001958_emphysema0.28282894
146MP0003959_abnormal_lean_body0.28048428
147MP0005646_abnormal_pituitary_gland0.27494906
148MP0005332_abnormal_amino_acid0.24580325
149MP0003122_maternal_imprinting0.24008616
150MP0003115_abnormal_respiratory_system0.23799007
151MP0005636_abnormal_mineral_homeostasis0.23776841
152MP0002063_abnormal_learning/memory/cond0.23770665
153MP0005595_abnormal_vascular_smooth0.23191455
154MP0002128_abnormal_blood_circulation0.22899322
155MP0003075_altered_response_to0.22470296
156MP0001440_abnormal_grooming_behavior0.22431725
157MP0004036_abnormal_muscle_relaxation0.22233394
158MP0002925_abnormal_cardiovascular_devel0.22219812
159MP0002152_abnormal_brain_morphology0.22024887
160MP0000604_amyloidosis0.20911175
161MP0002064_seizures0.20625291
162MP0002118_abnormal_lipid_homeostasis0.20049748
163MP0002733_abnormal_thermal_nociception0.19818601
164MP0004885_abnormal_endolymph0.19722899
165MP0003806_abnormal_nucleotide_metabolis0.19682394
166MP0004084_abnormal_cardiac_muscle0.18581601
167MP0001765_abnormal_ion_homeostasis0.18212848
168MP0000751_myopathy0.17678564
169MP0004134_abnormal_chest_morphology0.17498911
170MP0008469_abnormal_protein_level0.16885547
171MP0001784_abnormal_fluid_regulation0.16794956
172MP0006054_spinal_hemorrhage0.16762467
173MP0000955_abnormal_spinal_cord0.16335428
174MP0001663_abnormal_digestive_system0.16192923

Predicted human phenotypes

RankGene SetZ-score
1Congenital cataract (HP:0000519)7.87468036
2Corneal dystrophy (HP:0001131)7.08656818
3Amblyopia (HP:0000646)6.90080138
4Anterior segment dysgenesis (HP:0007700)5.86904499
5Thyroid-stimulating hormone excess (HP:0002925)5.72749684
6Ulnar claw (HP:0001178)4.54137105
7Polar cataract (HP:0010696)4.37404121
8Goiter (HP:0000853)4.37046595
9Clumsiness (HP:0002312)3.96431363
10Partial duplication of the phalanx of hand (HP:0009999)3.85213222
11Microcornea (HP:0000482)3.60825082
12Absent frontal sinuses (HP:0002688)3.51964774
13Partial duplication of thumb phalanx (HP:0009944)3.38577687
14Septo-optic dysplasia (HP:0100842)3.24260814
15Small epiphyses (HP:0010585)3.10760954
16Action tremor (HP:0002345)3.07935914
17Bifid tongue (HP:0010297)3.07727932
18Anomalous pulmonary venous return (HP:0010772)3.07155095
19Nuclear cataract (HP:0100018)27.3217741
20Zonular cataract (HP:0010920)24.1536622
21Duplication of thumb phalanx (HP:0009942)2.92808307
22Iris coloboma (HP:0000612)2.91344946
23Pancreatic cysts (HP:0001737)2.88162669
24Hyperthyroidism (HP:0000836)2.86769213
25Tubular atrophy (HP:0000092)2.79879307
26Eosinophilia (HP:0001880)2.77407033
27Genu varum (HP:0002970)2.73711626
28Absent thumb (HP:0009777)2.71770096
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68222867
30Morphological abnormality of the middle ear (HP:0008609)2.67042105
31Cutaneous finger syndactyly (HP:0010554)2.66025200
32Generalized myoclonic seizures (HP:0002123)2.64163291
33Sclerocornea (HP:0000647)2.63734817
34Renal cortical cysts (HP:0000803)2.62381643
35Short middle phalanx of the 5th finger (HP:0004220)2.57039757
36Abnormality of the renal cortex (HP:0011035)2.56560696
37Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.55855526
38Opacification of the corneal stroma (HP:0007759)2.55832951
39Abnormality of the pulmonary veins (HP:0011718)2.55141524
40Bile duct proliferation (HP:0001408)2.53847790
41Abnormal biliary tract physiology (HP:0012439)2.53847790
42Progressive inability to walk (HP:0002505)2.53142841
43Abnormality of the anterior chamber (HP:0000593)2.48000481
44Congenital primary aphakia (HP:0007707)2.45870702
45Tubulointerstitial nephritis (HP:0001970)2.43823836
46Irregular vertebral endplates (HP:0003301)2.43259062
47Abnormality of the frontal sinuses (HP:0002687)2.41774379
48Duplicated collecting system (HP:0000081)2.41770502
49Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40854338
50Irregular epiphyses (HP:0010582)2.40748597
51Increased hepatocellular lipid droplets (HP:0006565)2.39915810
52Abnormality of the vocal cords (HP:0008777)2.39100708
53Cystic liver disease (HP:0006706)2.38827045
54Hypoplastic left heart (HP:0004383)2.37294132
55Abnormal hair laboratory examination (HP:0003328)2.34560286
56Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.32682489
57Mesangial abnormality (HP:0001966)2.32509589
58Anophthalmia (HP:0000528)2.31592735
59Patent foramen ovale (HP:0001655)2.29625061
60Focal motor seizures (HP:0011153)2.28486152
61Cutaneous syndactyly (HP:0012725)2.26419482
62Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.24467164
63Supernumerary spleens (HP:0009799)2.22645189
64Mild short stature (HP:0003502)2.22464633
65Ulnar bowing (HP:0003031)2.22073768
66Bilateral microphthalmos (HP:0007633)2.21374697
67Asplenia (HP:0001746)2.20552892
68Lipid accumulation in hepatocytes (HP:0006561)2.20262649
69Granulocytopenia (HP:0001913)2.18588079
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.14306193
71Large for gestational age (HP:0001520)2.11926470
72Abnormality of methionine metabolism (HP:0010901)2.11776051
73Atonic seizures (HP:0010819)2.11655116
74Hypokinesia (HP:0002375)2.10591015
75Maternal diabetes (HP:0009800)2.10294141
76Abnormality of the renal collecting system (HP:0004742)2.09864386
77Hemiparesis (HP:0001269)2.08604022
78Disproportionate short-trunk short stature (HP:0003521)2.07109797
79Scapular winging (HP:0003691)2.04043359
80Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.03866321
81Proximal amyotrophy (HP:0007126)2.00923190
82Hypoplastic pelvis (HP:0008839)2.00492185
83Small hand (HP:0200055)2.00057128
84Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.99961762
85Midline defect of the nose (HP:0004122)1.99500899
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.98548814
87Methylmalonic acidemia (HP:0002912)1.97488554
88Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.97406751
89Vertebral hypoplasia (HP:0008417)1.97406751
90Aplasia/Hypoplasia of the lens (HP:0008063)1.96591058
91Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.96282627
92Tibial bowing (HP:0002982)1.94058638
93Abnormality of the vertebral endplates (HP:0005106)1.93880735
94Cupped ribs (HP:0000887)1.92701145
95Absence seizures (HP:0002121)1.92375920
96Stomatitis (HP:0010280)1.91582587
97Molar tooth sign on MRI (HP:0002419)1.90365455
98Abnormality of midbrain morphology (HP:0002418)1.90365455
99Hemivertebrae (HP:0002937)1.90257320
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89991634
101Abnormality of eosinophils (HP:0001879)1.87340467
102Polydipsia (HP:0001959)1.87235385
103Abnormal drinking behavior (HP:0030082)1.87235385
104Hip dysplasia (HP:0001385)1.87224683
105Peripheral hypomyelination (HP:0007182)1.86734404
106Reticulocytopenia (HP:0001896)1.86302005
107Metaphyseal cupping (HP:0003021)1.85244039
108Hypothermia (HP:0002045)1.83693529
109Poor head control (HP:0002421)1.79799494
110Abnormality of the phalanges of the 5th finger (HP:0004213)1.77291178
111Tubulointerstitial abnormality (HP:0001969)1.76264192
112Methylmalonic aciduria (HP:0012120)1.76043548
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74140124
114Posterior subcapsular cataract (HP:0007787)1.70229371
115Abnormal respiratory motile cilium physiology (HP:0012261)1.66412351
116Neonatal respiratory distress (HP:0002643)1.63741355
117Abnormal ciliary motility (HP:0012262)1.57856210
118Rhinitis (HP:0012384)1.57322740
119Aplasia/Hypoplasia of the macula (HP:0008059)1.52368707
120Fetal akinesia sequence (HP:0001989)1.47518698
121Popliteal pterygium (HP:0009756)1.42837662
122Aplasia/Hypoplasia affecting the retina (HP:0008061)1.42694637
123Aplasia of the musculature (HP:0100854)1.40845212
124Long clavicles (HP:0000890)1.35676229
125Abnormality of placental membranes (HP:0011409)1.31250222
126Amniotic constriction ring (HP:0009775)1.31250222
127Abnormality of the shoulder girdle musculature (HP:0001435)1.21828269
128Leukocytosis (HP:0001974)1.21025990
129Difficulty walking (HP:0002355)1.20849363
130Hypoplastic nipples (HP:0002557)1.18644796
131Akinesia (HP:0002304)1.17216170
132Abnormal respiratory epithelium morphology (HP:0012253)1.14935883
133Abnormal respiratory motile cilium morphology (HP:0005938)1.14935883
134Rib fusion (HP:0000902)1.08813927
135Chronic bronchitis (HP:0004469)0.97290784
136Fused cervical vertebrae (HP:0002949)0.96969484
137Symphalangism affecting the phalanges of the hand (HP:0009773)0.93635071
138Vertebral clefting (HP:0008428)0.92274408
139Chorioretinal coloboma (HP:0000567)0.88559807
140Subcapsular cataract (HP:0000523)0.84562370
141Aplasia/Hypoplasia involving the musculature (HP:0001460)0.81242559
142Hypoplastic heart (HP:0001961)0.79188010
143Enlarged kidneys (HP:0000105)0.75250055
144Abnormality of the labia majora (HP:0012881)0.75019513
145Dynein arm defect of respiratory motile cilia (HP:0012255)0.73731285
146Absent/shortened dynein arms (HP:0200106)0.73731285
147Pterygium (HP:0001059)0.69829469
148Thin ribs (HP:0000883)0.69568779
149Exostoses (HP:0100777)0.68858655
150Camptodactyly of toe (HP:0001836)0.65001555
151Bronchiectasis (HP:0002110)0.64742769
152Deep venous thrombosis (HP:0002625)0.64110098
153Malignant hyperthermia (HP:0002047)0.63669406
154Lymphangioma (HP:0100764)0.58314454
155Severe visual impairment (HP:0001141)0.57600450
156Abnormal number of incisors (HP:0011064)0.56422333
157Back pain (HP:0003418)0.50621341
158Exercise-induced myalgia (HP:0003738)0.50168789
159Atelectasis (HP:0100750)0.50161926
160Neonatal hypoglycemia (HP:0001998)0.49863506
161Aplasia/Hypoplasia of the nipples (HP:0006709)0.49159696
162Diminished movement (HP:0002374)0.48255470
163Abnormality of dentin (HP:0010299)0.47761458
164Nasal polyposis (HP:0100582)0.47265820
165Abnormality of aromatic amino acid family metabolism (HP:0004338)0.47247033
166Autosomal dominant inheritance (HP:0000006)0.46676226
167Annular pancreas (HP:0001734)0.45856656
168Hepatoblastoma (HP:0002884)0.45494574
169Cystic hygroma (HP:0000476)0.44897642
170Split foot (HP:0001839)0.43533124
171Abnormality of the humeroradial joint (HP:0100744)0.43523848
172Dislocated radial head (HP:0003083)0.42821051
173Hyporeflexia of lower limbs (HP:0002600)0.42802060
174Metaphyseal dysplasia (HP:0100255)0.42663724
175Neoplasm of head and neck (HP:0012288)0.42470555
176Esophageal neoplasm (HP:0100751)0.42470555
177Muscle fiber splitting (HP:0003555)0.42107948
178Flexion contracture of toe (HP:0005830)0.41995941
179Joint contractures involving the joints of the feet (HP:0100492)0.41995941
180Neoplasm of the heart (HP:0100544)0.41940128
181Abnormal pancreas size (HP:0012094)0.41516187
182Hemiplegia (HP:0002301)0.41513561
183Skin nodule (HP:0200036)0.41333922
184Intrahepatic cholestasis (HP:0001406)0.41241982
185Missing ribs (HP:0000921)0.41226733
186True hermaphroditism (HP:0010459)0.41152350
187Abnormalities of placenta or umbilical cord (HP:0001194)0.40420390
188Megalencephaly (HP:0001355)0.40299321
189Abnormality of the nasal mucosa (HP:0000433)0.40207094
190Short thorax (HP:0010306)0.39827554
191Recurrent sinusitis (HP:0011108)0.39780021
192Pancreatic fibrosis (HP:0100732)0.39385332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K67.98214079
2FRK4.90395301
3BLK4.66410027
4BMPR1B3.97667216
5PNCK3.92330805
6SGK13.90306509
7MST43.57080936
8SIK13.48869070
9TAF13.40413760
10MAPK153.25519589
11TNIK2.96361608
12FLT32.78090190
13MKNK22.76135130
14PRKG12.62551646
15FGFR22.54390049
16STK392.52234423
17WNK42.36203956
18NTRK12.24591066
19ACVR1B2.19027188
20DMPK2.03678345
21VRK12.01778844
22BCR1.99840232
23LRRK21.88005383
24PASK1.84298298
25RPS6KA41.82104382
26MAP3K41.80119628
27PKN21.75044506
28MAP2K71.74154032
29IGF1R1.68247820
30TYK21.67131873
31PRKD21.62611480
32PIK3CA1.56458680
33PRKCB1.53525531
34CDK81.51308588
35NUAK11.49284701
36KDR1.46043974
37MAPK101.41252707
38INSRR1.40556114
39PRKD31.39878772
40MET1.36744922
41INSR1.36365961
42STK101.31485630
43PDGFRA1.27783069
44TRIB31.22851223
45VRK21.21119448
46PLK31.21057686
47ZAK1.20200876
48PRKACB1.17815074
49SCYL21.14655515
50CASK1.14367629
51OXSR11.05077984
52CDK61.04278258
53PTK60.98521701
54ROCK20.97881823
55PAK40.95715201
56RPS6KA30.95544282
57PLK40.95078487
58NLK0.94458037
59ADRBK20.94359216
60PRKCQ0.91648415
61EPHB20.91208558
62CSNK1G10.90099807
63AKT30.88190341
64RPS6KA20.86735687
65CSNK1G30.85543354
66ERBB20.85327661
67PRKACG0.84060226
68DYRK1B0.82637248
69EPHA40.80992669
70UHMK10.80855277
71PKN10.80175325
72MAPKAPK50.79529684
73PTK20.79528354
74CDK30.79467518
75PRKAA10.79215409
76MAPK110.77642820
77ZAP700.76552366
78TYRO30.75716527
79CAMKK10.75484975
80PAK20.75075528
81PRKAA20.72539315
82MAP3K100.72522115
83TLK10.72341739
84CSNK1G20.71511457
85CSF1R0.71404322
86BRSK20.69173225
87WNK10.68634285
88CCNB10.66149344
89ICK0.66085951
90ERBB40.63939630
91STK38L0.62477904
92PHKG20.62421971
93PHKG10.62421971
94PTK2B0.61959529
95SGK4940.61560557
96SGK2230.61560557
97ILK0.61032385
98BCKDK0.60040214
99ROCK10.59674670
100MAP4K20.58801651
101TRIM280.57663040
102CAMK10.56975509
103RPS6KL10.56574109
104RPS6KC10.56574109
105CSNK2A20.56142863
106WNK30.54450600
107LATS10.54173332
108IRAK10.53936590
109RPS6KA50.53617053
110ADRBK10.50839171
111GRK10.50658457
112PLK10.49832378
113EPHA20.49242332
114PRKCG0.49240051
115MAPK120.49187675
116TGFBR10.45883463
117PRKCZ0.45748376
118PAK30.44794197
119PLK20.43986216
120EGFR0.43217448
121MAP3K70.42563695
122GSK3A0.42319463
123RPS6KA60.39632342
124RPS6KA10.38707938
125AKT20.38378103
126DYRK20.37045087
127JAK10.36918537
128MINK10.36301634
129MAP3K90.36187983
130HIPK20.35729557
131EIF2AK10.33059938
132LATS20.31786409
133CAMK1G0.31639827
134BMX0.31588196
135MAPKAPK20.30958673
136CSNK2A10.30610787
137CSNK1E0.30464783
138PRKACA0.30194701
139PRKCE0.29817757
140NTRK20.29453187
141BRSK10.28899109
142FGFR10.28729735
143CAMK2A0.28521137
144TBK10.27645121
145TNK20.26995804
146PBK0.26620021
147AKT10.25738375
148CDK50.25212206
149MST1R0.24996772
150TIE10.24941882
151PRKG20.24768228
152WEE10.24700426
153PRKCA0.24261136
154MAP2K20.23234441
155MAPK130.22822631
156PAK60.21358349
157SRC0.20822524
158FES0.20436045
159ITK0.19593973
160MYLK0.19419698
161MKNK10.18794802
162MAP3K80.18003328
163FGR0.16890418
164PRKCH0.16596792
165DAPK20.16384382
166RPS6KB10.16124302
167PRKCI0.15529257
168ARAF0.13797786
169JAK30.13410287

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.62020098
2Protein export_Homo sapiens_hsa030603.31051522
3Phototransduction_Homo sapiens_hsa047443.08990804
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.86965284
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71703782
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69741862
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66609257
8Folate biosynthesis_Homo sapiens_hsa007902.60573521
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41948271
10Nitrogen metabolism_Homo sapiens_hsa009102.30977679
11Butanoate metabolism_Homo sapiens_hsa006502.23503696
12Arginine biosynthesis_Homo sapiens_hsa002202.08122431
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05994310
14PPAR signaling pathway_Homo sapiens_hsa033201.89927320
15Fatty acid degradation_Homo sapiens_hsa000711.87656216
16Vitamin digestion and absorption_Homo sapiens_hsa049771.86390502
17Tryptophan metabolism_Homo sapiens_hsa003801.85428530
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84112027
19Complement and coagulation cascades_Homo sapiens_hsa046101.80730310
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73854140
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72524046
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71294730
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67543266
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66348860
25Hedgehog signaling pathway_Homo sapiens_hsa043401.65574033
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63855653
27Basal cell carcinoma_Homo sapiens_hsa052171.63690589
28Linoleic acid metabolism_Homo sapiens_hsa005911.62964228
29Collecting duct acid secretion_Homo sapiens_hsa049661.62454126
30Small cell lung cancer_Homo sapiens_hsa052221.56627493
31Bile secretion_Homo sapiens_hsa049761.49443080
32Fanconi anemia pathway_Homo sapiens_hsa034601.48992992
33Sulfur metabolism_Homo sapiens_hsa009201.47196741
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.40080399
35Circadian rhythm_Homo sapiens_hsa047101.38518552
36Biosynthesis of amino acids_Homo sapiens_hsa012301.38148917
37TGF-beta signaling pathway_Homo sapiens_hsa043501.37653447
38Propanoate metabolism_Homo sapiens_hsa006401.36797409
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34917333
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31113820
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28891769
42Histidine metabolism_Homo sapiens_hsa003401.27391893
43Fatty acid elongation_Homo sapiens_hsa000621.21676682
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.21357004
45Glutathione metabolism_Homo sapiens_hsa004801.19309685
46Nicotine addiction_Homo sapiens_hsa050331.18369410
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.14513778
48Melanogenesis_Homo sapiens_hsa049161.13804562
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12881179
50Fatty acid metabolism_Homo sapiens_hsa012121.12179529
51Chemical carcinogenesis_Homo sapiens_hsa052041.12011944
52Arginine and proline metabolism_Homo sapiens_hsa003301.11201561
53Starch and sucrose metabolism_Homo sapiens_hsa005001.08783660
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07023595
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06713547
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05699546
57Pyruvate metabolism_Homo sapiens_hsa006201.05586839
58Huntingtons disease_Homo sapiens_hsa050161.04791839
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04039165
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04004657
61Carbon metabolism_Homo sapiens_hsa012001.02807845
62GABAergic synapse_Homo sapiens_hsa047271.01962506
63Peroxisome_Homo sapiens_hsa041461.00616508
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00463875
65African trypanosomiasis_Homo sapiens_hsa051430.98983258
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98258456
67Insulin secretion_Homo sapiens_hsa049110.97302042
68Sphingolipid metabolism_Homo sapiens_hsa006000.96925353
69Alzheimers disease_Homo sapiens_hsa050100.96382375
70beta-Alanine metabolism_Homo sapiens_hsa004100.95296939
71RNA degradation_Homo sapiens_hsa030180.94452350
72Oxidative phosphorylation_Homo sapiens_hsa001900.93603632
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89431141
74Insulin signaling pathway_Homo sapiens_hsa049100.88241995
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88042834
76Wnt signaling pathway_Homo sapiens_hsa043100.87842241
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87823502
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87672569
79Prion diseases_Homo sapiens_hsa050200.85926855
80Olfactory transduction_Homo sapiens_hsa047400.85407912
81Homologous recombination_Homo sapiens_hsa034400.85310206
82Gastric acid secretion_Homo sapiens_hsa049710.83459648
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82968705
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.82659941
85Circadian entrainment_Homo sapiens_hsa047130.82659892
86Glucagon signaling pathway_Homo sapiens_hsa049220.81448525
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81288693
88Ovarian steroidogenesis_Homo sapiens_hsa049130.79420888
89ECM-receptor interaction_Homo sapiens_hsa045120.79192407
90Parkinsons disease_Homo sapiens_hsa050120.78276932
91Steroid biosynthesis_Homo sapiens_hsa001000.77743442
92Amoebiasis_Homo sapiens_hsa051460.75546744
93RNA polymerase_Homo sapiens_hsa030200.72770147
94Selenocompound metabolism_Homo sapiens_hsa004500.69069152
95Ribosome_Homo sapiens_hsa030100.67719653
96Staphylococcus aureus infection_Homo sapiens_hsa051500.66766369
97Adherens junction_Homo sapiens_hsa045200.66259350
98Autoimmune thyroid disease_Homo sapiens_hsa053200.65736378
99Arachidonic acid metabolism_Homo sapiens_hsa005900.65353405
100Sulfur relay system_Homo sapiens_hsa041220.63729529
101Serotonergic synapse_Homo sapiens_hsa047260.63696043
102Regulation of autophagy_Homo sapiens_hsa041400.62521082
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62237797
104One carbon pool by folate_Homo sapiens_hsa006700.62235164
105Protein digestion and absorption_Homo sapiens_hsa049740.61656545
106Tight junction_Homo sapiens_hsa045300.61621924
107Cardiac muscle contraction_Homo sapiens_hsa042600.60862185
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.60245816
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.60041043
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59889802
111Proteoglycans in cancer_Homo sapiens_hsa052050.58629368
112Hippo signaling pathway_Homo sapiens_hsa043900.58572713
113Calcium signaling pathway_Homo sapiens_hsa040200.56751591
114Insulin resistance_Homo sapiens_hsa049310.56597402
115Melanoma_Homo sapiens_hsa052180.55504395
116Retinol metabolism_Homo sapiens_hsa008300.55241452
117cAMP signaling pathway_Homo sapiens_hsa040240.54860795
118N-Glycan biosynthesis_Homo sapiens_hsa005100.53858523
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53225126
120Taste transduction_Homo sapiens_hsa047420.53136608
121Morphine addiction_Homo sapiens_hsa050320.51764770
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50401307
123Galactose metabolism_Homo sapiens_hsa000520.50105380
124Basal transcription factors_Homo sapiens_hsa030220.50052080
125Tyrosine metabolism_Homo sapiens_hsa003500.49782417
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.49288118
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.49279038
128Pathways in cancer_Homo sapiens_hsa052000.48712435
129Caffeine metabolism_Homo sapiens_hsa002320.47943233
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46579408
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46498239
132Glycerolipid metabolism_Homo sapiens_hsa005610.45960748
133Dopaminergic synapse_Homo sapiens_hsa047280.45503383
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44594164
135Ether lipid metabolism_Homo sapiens_hsa005650.44275934
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43969562
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43829062
138Cocaine addiction_Homo sapiens_hsa050300.43292312
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43272061
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42933957
141mTOR signaling pathway_Homo sapiens_hsa041500.41754829
142Thyroid hormone synthesis_Homo sapiens_hsa049180.41664875
143Metabolic pathways_Homo sapiens_hsa011000.41526276
144Glutamatergic synapse_Homo sapiens_hsa047240.40163578
145Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39941682
146Phenylalanine metabolism_Homo sapiens_hsa003600.39070121
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38827437
148Gap junction_Homo sapiens_hsa045400.38752201
149Purine metabolism_Homo sapiens_hsa002300.38189557
150Amphetamine addiction_Homo sapiens_hsa050310.38122347
151ABC transporters_Homo sapiens_hsa020100.37979365
152Lysosome_Homo sapiens_hsa041420.37628360
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37531547
154Salivary secretion_Homo sapiens_hsa049700.36805215
155Thyroid cancer_Homo sapiens_hsa052160.34093731

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