Rank | Gene Set | Z-score |
---|---|---|
1 | drug transmembrane transport (GO:0006855) | 6.45160761 |
2 | urate metabolic process (GO:0046415) | 5.88312175 |
3 | drug transport (GO:0015893) | 5.77922351 |
4 | glucuronate metabolic process (GO:0019585) | 5.55997138 |
5 | uronic acid metabolic process (GO:0006063) | 5.55997138 |
6 | aminoglycoside antibiotic metabolic process (GO:0030647) | 5.36747572 |
7 | cellular glucuronidation (GO:0052695) | 5.29784191 |
8 | lysine catabolic process (GO:0006554) | 5.15012913 |
9 | lysine metabolic process (GO:0006553) | 5.15012913 |
10 | epoxygenase P450 pathway (GO:0019373) | 5.05553853 |
11 | cysteine metabolic process (GO:0006534) | 5.01757677 |
12 | drug catabolic process (GO:0042737) | 4.94313207 |
13 | xenobiotic catabolic process (GO:0042178) | 4.75160803 |
14 | glyoxylate metabolic process (GO:0046487) | 4.69464089 |
15 | organic cation transport (GO:0015695) | 4.66664204 |
16 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.59150830 |
17 | L-phenylalanine metabolic process (GO:0006558) | 4.59150830 |
18 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 4.46406299 |
19 | L-phenylalanine catabolic process (GO:0006559) | 4.46406299 |
20 | renal absorption (GO:0070293) | 4.45701723 |
21 | response to nitrosative stress (GO:0051409) | 4.40945674 |
22 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.38028939 |
23 | aromatic amino acid family catabolic process (GO:0009074) | 4.36120889 |
24 | tryptophan catabolic process (GO:0006569) | 4.35256332 |
25 | indole-containing compound catabolic process (GO:0042436) | 4.35256332 |
26 | indolalkylamine catabolic process (GO:0046218) | 4.35256332 |
27 | sulfur amino acid catabolic process (GO:0000098) | 4.33536420 |
28 | exogenous drug catabolic process (GO:0042738) | 4.31041599 |
29 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 4.30584433 |
30 | regulation of cholesterol esterification (GO:0010872) | 4.26515138 |
31 | angiotensin maturation (GO:0002003) | 4.25540566 |
32 | peptide catabolic process (GO:0043171) | 4.22061073 |
33 | flavonoid metabolic process (GO:0009812) | 4.20393601 |
34 | tryptophan metabolic process (GO:0006568) | 4.15804932 |
35 | vitamin D metabolic process (GO:0042359) | 4.12288667 |
36 | toxin transport (GO:1901998) | 4.04712070 |
37 | benzene-containing compound metabolic process (GO:0042537) | 3.96235904 |
38 | aldehyde catabolic process (GO:0046185) | 3.94753876 |
39 | short-chain fatty acid metabolic process (GO:0046459) | 3.93613375 |
40 | valine metabolic process (GO:0006573) | 3.93596988 |
41 | tricarboxylic acid metabolic process (GO:0072350) | 3.83688795 |
42 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 3.82359043 |
43 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 3.82359043 |
44 | amino-acid betaine metabolic process (GO:0006577) | 3.80257024 |
45 | high-density lipoprotein particle remodeling (GO:0034375) | 3.78640061 |
46 | homocysteine metabolic process (GO:0050667) | 3.76936413 |
47 | glutathione derivative biosynthetic process (GO:1901687) | 3.73592947 |
48 | glutathione derivative metabolic process (GO:1901685) | 3.73592947 |
49 | low-density lipoprotein particle remodeling (GO:0034374) | 3.72942226 |
50 | phosphate ion transport (GO:0006817) | 3.69259208 |
51 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.69015273 |
52 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.69015273 |
53 | L-ascorbic acid metabolic process (GO:0019852) | 3.65136146 |
54 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 3.59772516 |
55 | reverse cholesterol transport (GO:0043691) | 3.59698729 |
56 | protein-lipid complex remodeling (GO:0034368) | 3.59328508 |
57 | macromolecular complex remodeling (GO:0034367) | 3.59328508 |
58 | plasma lipoprotein particle remodeling (GO:0034369) | 3.59328508 |
59 | complement activation, alternative pathway (GO:0006957) | 3.59030060 |
60 | quaternary ammonium group transport (GO:0015697) | 3.58308599 |
61 | carnitine metabolic process (GO:0009437) | 3.54960942 |
62 | fatty acid beta-oxidation (GO:0006635) | 3.54901147 |
63 | negative regulation of cholesterol transport (GO:0032375) | 3.51446411 |
64 | negative regulation of sterol transport (GO:0032372) | 3.51446411 |
65 | phenylpropanoid metabolic process (GO:0009698) | 3.51078162 |
66 | phospholipid efflux (GO:0033700) | 3.49971828 |
67 | nitrogen cycle metabolic process (GO:0071941) | 3.48811202 |
68 | nonribosomal peptide biosynthetic process (GO:0019184) | 3.47780090 |
69 | glutathione metabolic process (GO:0006749) | 3.45494985 |
70 | omega-hydroxylase P450 pathway (GO:0097267) | 3.44001075 |
71 | kynurenine metabolic process (GO:0070189) | 3.43808188 |
72 | fatty acid oxidation (GO:0019395) | 3.42460488 |
73 | glycosphingolipid catabolic process (GO:0046479) | 3.41578514 |
74 | branched-chain amino acid metabolic process (GO:0009081) | 3.38899602 |
75 | response to mercury ion (GO:0046689) | 3.36707174 |
76 | lipid oxidation (GO:0034440) | 3.36296686 |
77 | regulation of protein activation cascade (GO:2000257) | 3.32730817 |
78 | glycoside metabolic process (GO:0016137) | 3.31392623 |
79 | cholesterol efflux (GO:0033344) | 3.30838054 |
80 | regulation of triglyceride catabolic process (GO:0010896) | 3.29738593 |
81 | blood coagulation, intrinsic pathway (GO:0007597) | 3.29693619 |
82 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.28560816 |
83 | excretion (GO:0007588) | 3.26777080 |
84 | proline metabolic process (GO:0006560) | 3.25172956 |
85 | cellular modified amino acid catabolic process (GO:0042219) | 3.24759618 |
86 | glucose 6-phosphate metabolic process (GO:0051156) | 3.23502627 |
87 | cellular ketone body metabolic process (GO:0046950) | 3.21909333 |
88 | regulation of complement activation (GO:0030449) | 3.21069219 |
89 | modified amino acid transport (GO:0072337) | 3.19928815 |
90 | serine family amino acid catabolic process (GO:0009071) | 3.18401999 |
91 | glycolipid catabolic process (GO:0019377) | 3.17981229 |
92 | aromatic amino acid family metabolic process (GO:0009072) | 3.17632987 |
93 | glutathione biosynthetic process (GO:0006750) | 3.17250421 |
94 | ethanol oxidation (GO:0006069) | 3.17236823 |
95 | hormone catabolic process (GO:0042447) | 3.16352214 |
96 | negative regulation of fibrinolysis (GO:0051918) | 3.16348275 |
97 | monocarboxylic acid catabolic process (GO:0072329) | 3.15741021 |
98 | bile acid metabolic process (GO:0008206) | 3.15429098 |
99 | bile acid and bile salt transport (GO:0015721) | 3.14616607 |
100 | drug metabolic process (GO:0017144) | 3.14065562 |
101 | fructose metabolic process (GO:0006000) | 3.13759227 |
102 | regulation of fibrinolysis (GO:0051917) | 3.12675147 |
103 | fatty acid catabolic process (GO:0009062) | 3.12307401 |
104 | oligosaccharide catabolic process (GO:0009313) | 3.11710460 |
105 | fat-soluble vitamin biosynthetic process (GO:0042362) | 3.11444474 |
106 | vitamin transport (GO:0051180) | 3.09002326 |
107 | bile acid biosynthetic process (GO:0006699) | 3.07994022 |
108 | fibrinolysis (GO:0042730) | 3.05669789 |
109 | indolalkylamine metabolic process (GO:0006586) | 3.05438956 |
110 | serine family amino acid metabolic process (GO:0009069) | 3.04171036 |
111 | phosphate ion transmembrane transport (GO:0035435) | 3.04127591 |
112 | negative regulation of blood coagulation (GO:0030195) | 3.03794484 |
113 | negative regulation of hemostasis (GO:1900047) | 3.03794484 |
114 | sulfur amino acid metabolic process (GO:0000096) | 2.99643726 |
115 | plasma lipoprotein particle assembly (GO:0034377) | 2.98649559 |
116 | transepithelial transport (GO:0070633) | 2.97201163 |
117 | xenobiotic metabolic process (GO:0006805) | 2.96363041 |
118 | NADH metabolic process (GO:0006734) | 2.95882164 |
119 | 2-oxoglutarate metabolic process (GO:0006103) | 2.95276040 |
120 | organic acid catabolic process (GO:0016054) | 2.95175668 |
121 | carboxylic acid catabolic process (GO:0046395) | 2.95175668 |
122 | amine catabolic process (GO:0009310) | 2.94848976 |
123 | cellular biogenic amine catabolic process (GO:0042402) | 2.94848976 |
124 | aspartate family amino acid catabolic process (GO:0009068) | 2.94824101 |
125 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 2.93073752 |
126 | plasma lipoprotein particle organization (GO:0071827) | 2.92731422 |
127 | cellular amino acid catabolic process (GO:0009063) | 2.92682179 |
128 | protein carboxylation (GO:0018214) | 2.92262552 |
129 | peptidyl-glutamic acid carboxylation (GO:0017187) | 2.92262552 |
130 | regulation of cholesterol homeostasis (GO:2000188) | 2.90495978 |
131 | urea metabolic process (GO:0019627) | 2.89877446 |
132 | urea cycle (GO:0000050) | 2.89877446 |
133 | branched-chain amino acid catabolic process (GO:0009083) | 2.87909580 |
134 | protein activation cascade (GO:0072376) | 2.86766567 |
135 | protein-lipid complex subunit organization (GO:0071825) | 2.85014993 |
136 | negative regulation of coagulation (GO:0050819) | 2.84307531 |
137 | protein-lipid complex assembly (GO:0065005) | 2.83845201 |
138 | alpha-amino acid catabolic process (GO:1901606) | 2.83638747 |
139 | ceramide catabolic process (GO:0046514) | 2.81707849 |
140 | ethanol metabolic process (GO:0006067) | 2.81309351 |
141 | signal peptide processing (GO:0006465) | 2.80408581 |
142 | lipoprotein transport (GO:0042953) | 2.80376200 |
143 | polyol transport (GO:0015791) | 2.80176859 |
144 | lipoprotein metabolic process (GO:0042157) | 2.79508625 |
145 | phosphate ion homeostasis (GO:0055062) | 2.79223848 |
146 | trivalent inorganic anion homeostasis (GO:0072506) | 2.79223848 |
147 | acylglycerol homeostasis (GO:0055090) | 2.78045494 |
148 | triglyceride homeostasis (GO:0070328) | 2.78045494 |
149 | intestinal absorption (GO:0050892) | 2.77212427 |
150 | nicotinamide nucleotide biosynthetic process (GO:0019359) | 2.76833127 |
151 | regulation of cholesterol transport (GO:0032374) | 2.72310293 |
152 | regulation of sterol transport (GO:0032371) | 2.72310293 |
153 | complement activation, classical pathway (GO:0006958) | 2.71843922 |
154 | acute-phase response (GO:0006953) | 2.71110848 |
155 | complement activation (GO:0006956) | 2.66941088 |
156 | plasma lipoprotein particle clearance (GO:0034381) | 2.63912470 |
157 | tyrosine metabolic process (GO:0006570) | 2.60663677 |
158 | phospholipid homeostasis (GO:0055091) | 2.60151302 |
159 | arginine metabolic process (GO:0006525) | 2.58774722 |
160 | positive regulation of cellular amine metabolic process (GO:0033240) | 2.53177833 |
161 | alkaloid metabolic process (GO:0009820) | 2.52650356 |
162 | cholesterol homeostasis (GO:0042632) | 2.52067963 |
163 | negative regulation of wound healing (GO:0061045) | 2.51145307 |
164 | neutrophil activation involved in immune response (GO:0002283) | 2.50578295 |
165 | positive regulation of blood coagulation (GO:0030194) | 2.49335778 |
166 | positive regulation of hemostasis (GO:1900048) | 2.49335778 |
167 | arachidonic acid metabolic process (GO:0019369) | 2.49296640 |
168 | cyclooxygenase pathway (GO:0019371) | 2.47078055 |
169 | sterol homeostasis (GO:0055092) | 2.46007703 |
170 | positive regulation of steroid metabolic process (GO:0045940) | 2.45564965 |
171 | regulation of cholesterol metabolic process (GO:0090181) | 2.45143524 |
172 | positive regulation of coagulation (GO:0050820) | 2.42992145 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 6.96518451 |
2 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 5.39348823 |
3 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 4.93443415 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 4.23167626 |
5 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.01320300 |
6 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 3.91315132 |
7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 3.68843561 |
8 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.94187605 |
9 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.85208433 |
10 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.72706938 |
11 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.70087682 |
12 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 2.69218470 |
13 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.49603646 |
14 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.47555408 |
15 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.47168381 |
16 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.24066483 |
17 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.20789450 |
18 | GATA1_22025678_ChIP-Seq_K562_Human | 2.12355221 |
19 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 2.09172253 |
20 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.08506097 |
21 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 2.06002157 |
22 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.05939934 |
23 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.05262432 |
24 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.96814392 |
25 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.88186071 |
26 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.86871234 |
27 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.81779686 |
28 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.72824943 |
29 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.72445712 |
30 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.70409729 |
31 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.68096770 |
32 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.60419987 |
33 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.57599710 |
34 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.57452510 |
35 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.45317691 |
36 | * SOX2_20726797_ChIP-Seq_SW620_Human | 1.44614936 |
37 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44107134 |
38 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.43379824 |
39 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.43017561 |
40 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.41373612 |
41 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41355380 |
42 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.40470719 |
43 | * FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.40307674 |
44 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.38768201 |
45 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.36295890 |
46 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.34791156 |
47 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.34463284 |
48 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.33299127 |
49 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.25284214 |
50 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.24941778 |
51 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.24292481 |
52 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.18957166 |
53 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.18570579 |
54 | GATA1_19941826_ChIP-Seq_K562_Human | 1.16739614 |
55 | SPI1_23127762_ChIP-Seq_K562_Human | 1.16176486 |
56 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.15173051 |
57 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.14790943 |
58 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.12160812 |
59 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.10545551 |
60 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.10097457 |
61 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.09310363 |
62 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.08504853 |
63 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.06199359 |
64 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.04951464 |
65 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.03653091 |
66 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02652615 |
67 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.02635291 |
68 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.01197086 |
69 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.00404781 |
70 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.99751220 |
71 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.99714824 |
72 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99483754 |
73 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.97471949 |
74 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.97273714 |
75 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.97083750 |
76 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.95108268 |
77 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.94931683 |
78 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.94222464 |
79 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.93121249 |
80 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.92945123 |
81 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.91831736 |
82 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.91715530 |
83 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.90758060 |
84 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.89753088 |
85 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.89365231 |
86 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.89358203 |
87 | GATA2_19941826_ChIP-Seq_K562_Human | 0.89091172 |
88 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.88488713 |
89 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88477971 |
90 | * SPI1_23547873_ChIP-Seq_NB4_Human | 0.88007312 |
91 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.87141992 |
92 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.86994803 |
93 | * FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.86011622 |
94 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.85293700 |
95 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.85278293 |
96 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.85278293 |
97 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.84708322 |
98 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.84165317 |
99 | GATA3_26560356_Chip-Seq_TH2_Human | 0.84088664 |
100 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.84087801 |
101 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.84009172 |
102 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.82924252 |
103 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.82853551 |
104 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.82844321 |
105 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.82221429 |
106 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.82181433 |
107 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.81370930 |
108 | AR_20517297_ChIP-Seq_VCAP_Human | 0.80950411 |
109 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.80796213 |
110 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.80796132 |
111 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.79892114 |
112 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.79463859 |
113 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.79137967 |
114 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.78978558 |
115 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.78008079 |
116 | * SA1_27219007_Chip-Seq_Bcells_Human | 0.77474858 |
117 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.77067666 |
118 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.76978959 |
119 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.76406944 |
120 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.76213896 |
121 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.75634338 |
122 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.75558381 |
123 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.74269263 |
124 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.74248288 |
125 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.74089644 |
126 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.73206553 |
127 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.72098240 |
128 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.71899070 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005360_urolithiasis | 6.64617774 |
2 | MP0002139_abnormal_hepatobiliary_system | 5.25265540 |
3 | MP0008875_abnormal_xenobiotic_pharmacok | 4.09201368 |
4 | MP0004043_abnormal_pH_regulation | 3.77120463 |
5 | MP0005365_abnormal_bile_salt | 3.36904130 |
6 | MP0004019_abnormal_vitamin_homeostasis | 3.31285315 |
7 | MP0003195_calcinosis | 3.20070027 |
8 | MP0005085_abnormal_gallbladder_physiolo | 3.12384282 |
9 | MP0005058_abnormal_lysosome_morphology | 3.06220074 |
10 | MP0005332_abnormal_amino_acid | 2.99769453 |
11 | MP0009643_abnormal_urine_homeostasis | 2.91195145 |
12 | MP0002138_abnormal_hepatobiliary_system | 2.56584252 |
13 | MP0003252_abnormal_bile_duct | 2.48661798 |
14 | MP0009840_abnormal_foam_cell | 2.43406717 |
15 | MP0001666_abnormal_nutrient_absorption | 2.31991501 |
16 | MP0003303_peritoneal_inflammation | 2.31689145 |
17 | MP0005636_abnormal_mineral_homeostasis | 2.18023553 |
18 | MP0003186_abnormal_redox_activity | 2.13338238 |
19 | MP0001765_abnormal_ion_homeostasis | 2.12762758 |
20 | MP0003191_abnormal_cellular_cholesterol | 2.06062681 |
21 | MP0001756_abnormal_urination | 1.99180298 |
22 | MP0003806_abnormal_nucleotide_metabolis | 1.89024307 |
23 | MP0002136_abnormal_kidney_physiology | 1.87520244 |
24 | MP0000678_abnormal_parathyroid_gland | 1.86052655 |
25 | MP0010329_abnormal_lipoprotein_level | 1.83314696 |
26 | MP0003879_abnormal_hair_cell | 1.73463423 |
27 | MP0002876_abnormal_thyroid_physiology | 1.66228765 |
28 | MP0003868_abnormal_feces_composition | 1.62910537 |
29 | MP0001835_abnormal_antigen_presentation | 1.62111466 |
30 | MP0005167_abnormal_blood-brain_barrier | 1.61792282 |
31 | MP0005319_abnormal_enzyme/_coenzyme | 1.61564077 |
32 | MP0003724_increased_susceptibility_to | 1.59528455 |
33 | MP0001764_abnormal_homeostasis | 1.54134781 |
34 | MP0003183_abnormal_peptide_metabolism | 1.50259270 |
35 | MP0003329_amyloid_beta_deposits | 1.42741849 |
36 | MP0004264_abnormal_extraembryonic_tissu | 1.42267126 |
37 | MP0003300_gastrointestinal_ulcer | 1.40827120 |
38 | MP0000538_abnormal_urinary_bladder | 1.38153953 |
39 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.33729477 |
40 | MP0003436_decreased_susceptibility_to | 1.33059642 |
41 | MP0006082_CNS_inflammation | 1.30998419 |
42 | MP0000343_altered_response_to | 1.30665822 |
43 | MP0000609_abnormal_liver_physiology | 1.28221324 |
44 | MP0009764_decreased_sensitivity_to | 1.25405203 |
45 | MP0008469_abnormal_protein_level | 1.23961756 |
46 | MP0003172_abnormal_lysosome_physiology | 1.23380043 |
47 | MP0002118_abnormal_lipid_homeostasis | 1.22622127 |
48 | MP0005377_hearing/vestibular/ear_phenot | 1.17406476 |
49 | MP0003878_abnormal_ear_physiology | 1.17406476 |
50 | MP0005451_abnormal_body_composition | 1.16756541 |
51 | MP0005310_abnormal_salivary_gland | 1.12641930 |
52 | MP0010155_abnormal_intestine_physiology | 1.11552045 |
53 | MP0002928_abnormal_bile_duct | 1.11057689 |
54 | MP0002254_reproductive_system_inflammat | 1.08895099 |
55 | MP0002148_abnormal_hypersensitivity_rea | 1.08468424 |
56 | MP0000920_abnormal_myelination | 1.03895611 |
57 | MP0001845_abnormal_inflammatory_respons | 1.03175837 |
58 | MP0005464_abnormal_platelet_physiology | 1.00684315 |
59 | MP0005408_hypopigmentation | 1.00368459 |
60 | MP0003075_altered_response_to | 1.00366538 |
61 | MP0005387_immune_system_phenotype | 0.99660527 |
62 | MP0001790_abnormal_immune_system | 0.99660527 |
63 | MP0001501_abnormal_sleep_pattern | 0.99117757 |
64 | MP0001663_abnormal_digestive_system | 0.97758190 |
65 | MP0002419_abnormal_innate_immunity | 0.96536634 |
66 | MP0000465_gastrointestinal_hemorrhage | 0.96347052 |
67 | MP0002971_abnormal_brown_adipose | 0.96013747 |
68 | MP0006036_abnormal_mitochondrial_physio | 0.94744505 |
69 | MP0009642_abnormal_blood_homeostasis | 0.93753280 |
70 | MP0008260_abnormal_autophagy | 0.93459137 |
71 | MP0005165_increased_susceptibility_to | 0.91794677 |
72 | MP0004782_abnormal_surfactant_physiolog | 0.91374943 |
73 | MP0004510_myositis | 0.89998194 |
74 | MP0010234_abnormal_vibrissa_follicle | 0.89033901 |
75 | MP0005084_abnormal_gallbladder_morpholo | 0.87692616 |
76 | MP0005166_decreased_susceptibility_to | 0.87640044 |
77 | MP0000230_abnormal_systemic_arterial | 0.86496242 |
78 | MP0001664_abnormal_digestion | 0.86175780 |
79 | MP0005535_abnormal_body_temperature | 0.85072998 |
80 | MP0005025_abnormal_response_to | 0.84335579 |
81 | MP0000249_abnormal_blood_vessel | 0.84046036 |
82 | MP0003866_abnormal_defecation | 0.82676139 |
83 | MP0005000_abnormal_immune_tolerance | 0.82142939 |
84 | MP0000598_abnormal_liver_morphology | 0.81921659 |
85 | MP0009785_altered_susceptibility_to | 0.80811685 |
86 | MP0001533_abnormal_skeleton_physiology | 0.79689934 |
87 | MP0005381_digestive/alimentary_phenotyp | 0.79317129 |
88 | MP0002998_abnormal_bone_remodeling | 0.79165797 |
89 | MP0002135_abnormal_kidney_morphology | 0.78150564 |
90 | MP0005670_abnormal_white_adipose | 0.78054803 |
91 | MP0004147_increased_porphyrin_level | 0.75893845 |
92 | MP0005448_abnormal_energy_balance | 0.75304196 |
93 | MP0004947_skin_inflammation | 0.73494346 |
94 | MP0005220_abnormal_exocrine_pancreas | 0.73386575 |
95 | MP0002723_abnormal_immune_serum | 0.72580975 |
96 | MP0003638_abnormal_response/metabolism_ | 0.72349374 |
97 | MP0002877_abnormal_melanocyte_morpholog | 0.72121468 |
98 | MP0002078_abnormal_glucose_homeostasis | 0.71670169 |
99 | MP0001958_emphysema | 0.71204765 |
100 | MP0002896_abnormal_bone_mineralization | 0.70823976 |
101 | MP0000604_amyloidosis | 0.70363990 |
102 | MP0008874_decreased_physiological_sensi | 0.69685723 |
103 | MP0008961_abnormal_basal_metabolism | 0.68981928 |
104 | MP0000685_abnormal_immune_system | 0.68535370 |
105 | MP0009379_abnormal_foot_pigmentation | 0.67938951 |
106 | MP0002909_abnormal_adrenal_gland | 0.67425297 |
107 | MP0003633_abnormal_nervous_system | 0.66752336 |
108 | MP0002405_respiratory_system_inflammati | 0.66533539 |
109 | MP0001873_stomach_inflammation | 0.65952277 |
110 | MP0009763_increased_sensitivity_to | 0.65562106 |
111 | MP0002132_abnormal_respiratory_system | 0.65454606 |
112 | MP0002098_abnormal_vibrissa_morphology | 0.65032343 |
113 | MP0002693_abnormal_pancreas_physiology | 0.65020428 |
114 | MP0003690_abnormal_glial_cell | 0.63892375 |
115 | MP0005397_hematopoietic_system_phenotyp | 0.63762885 |
116 | MP0001545_abnormal_hematopoietic_system | 0.63762885 |
117 | MP0005409_darkened_coat_color | 0.63473429 |
118 | MP0010386_abnormal_urinary_bladder | 0.62400872 |
119 | MP0002452_abnormal_antigen_presenting | 0.62368307 |
120 | MP0009765_abnormal_xenobiotic_induced | 0.62294277 |
121 | MP0001800_abnormal_humoral_immune | 0.61502468 |
122 | MP0003656_abnormal_erythrocyte_physiolo | 0.61240636 |
123 | MP0009780_abnormal_chondrocyte_physiolo | 0.60834391 |
124 | MP0005671_abnormal_response_to | 0.60686718 |
125 | MP0008004_abnormal_stomach_pH | 0.60461658 |
126 | MP0008872_abnormal_physiological_respon | 0.60178319 |
127 | MP0003011_delayed_dark_adaptation | 0.59230300 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Generalized aminoaciduria (HP:0002909) | 5.38298938 |
2 | Hyperactive renin-angiotensin system (HP:0000841) | 4.54125722 |
3 | Metabolic alkalosis (HP:0200114) | 4.43107286 |
4 | Gout (HP:0001997) | 4.41006411 |
5 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.22512614 |
6 | Proximal tubulopathy (HP:0000114) | 4.17060050 |
7 | Hypokalemic alkalosis (HP:0001949) | 4.06151702 |
8 | Purpura (HP:0000979) | 4.05741249 |
9 | Abnormality of chloride homeostasis (HP:0011422) | 4.02523877 |
10 | Abnormality of complement system (HP:0005339) | 4.01358966 |
11 | Increased circulating renin level (HP:0000848) | 4.00047023 |
12 | Hyperglycinuria (HP:0003108) | 3.96404546 |
13 | Deep venous thrombosis (HP:0002625) | 3.94786341 |
14 | Abnormality of magnesium homeostasis (HP:0004921) | 3.84706193 |
15 | Hyperlipoproteinemia (HP:0010980) | 3.78976211 |
16 | Polyuria (HP:0000103) | 3.76877035 |
17 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.74492521 |
18 | Vacuolated lymphocytes (HP:0001922) | 3.74378652 |
19 | Systemic lupus erythematosus (HP:0002725) | 3.71307220 |
20 | Abnormality of glycolipid metabolism (HP:0010969) | 3.68668094 |
21 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.68668094 |
22 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.68668094 |
23 | Abnormality of purine metabolism (HP:0004352) | 3.67556834 |
24 | Abnormal urine output (HP:0012590) | 3.66285908 |
25 | Dysostosis multiplex (HP:0000943) | 3.55125730 |
26 | Hypomagnesemia (HP:0002917) | 3.54782666 |
27 | Glycosuria (HP:0003076) | 3.53656181 |
28 | Abnormality of urine glucose concentration (HP:0011016) | 3.53656181 |
29 | Abnormality of renal excretion (HP:0011036) | 3.49467440 |
30 | Alkalosis (HP:0001948) | 3.47658493 |
31 | Renal tubular acidosis (HP:0001947) | 3.46530593 |
32 | Ketoacidosis (HP:0001993) | 3.43162040 |
33 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.39079341 |
34 | Mucopolysacchariduria (HP:0008155) | 3.39042396 |
35 | Urinary glycosaminoglycan excretion (HP:0003541) | 3.39042396 |
36 | Abnormal drinking behavior (HP:0030082) | 3.30070617 |
37 | Polydipsia (HP:0001959) | 3.30070617 |
38 | Joint hemorrhage (HP:0005261) | 3.20775437 |
39 | Abnormality of renin-angiotensin system (HP:0000847) | 3.16227149 |
40 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 3.15979714 |
41 | Abnormality of polysaccharide metabolism (HP:0011012) | 3.15979714 |
42 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 3.15979714 |
43 | Abnormality of glycine metabolism (HP:0010895) | 3.14274778 |
44 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.14274778 |
45 | Ketosis (HP:0001946) | 3.12754473 |
46 | Increased purine levels (HP:0004368) | 3.11595110 |
47 | Hyperuricemia (HP:0002149) | 3.11595110 |
48 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 3.06865968 |
49 | Abnormality of nucleobase metabolism (HP:0010932) | 3.02832020 |
50 | Hyperphosphaturia (HP:0003109) | 3.01788906 |
51 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.99185048 |
52 | Prolonged partial thromboplastin time (HP:0003645) | 2.97267215 |
53 | Gingival bleeding (HP:0000225) | 2.96597032 |
54 | Tetany (HP:0001281) | 2.87938633 |
55 | Hypoglycemic coma (HP:0001325) | 2.85619363 |
56 | Menorrhagia (HP:0000132) | 2.83958610 |
57 | Hyperaldosteronism (HP:0000859) | 2.82883823 |
58 | Delayed epiphyseal ossification (HP:0002663) | 2.79144808 |
59 | Hyperammonemia (HP:0001987) | 2.78977397 |
60 | Prolonged bleeding time (HP:0003010) | 2.70042544 |
61 | Intrahepatic cholestasis (HP:0001406) | 2.69928472 |
62 | Hydroxyprolinuria (HP:0003080) | 2.67542264 |
63 | Abnormality of proline metabolism (HP:0010907) | 2.67542264 |
64 | Amyloidosis (HP:0011034) | 2.65618007 |
65 | Malnutrition (HP:0004395) | 2.63114999 |
66 | Nephritis (HP:0000123) | 2.61951114 |
67 | Increased cerebral lipofuscin (HP:0011813) | 2.61061939 |
68 | Abnormal urine phosphate concentration (HP:0012599) | 2.59158298 |
69 | Widely patent fontanelles and sutures (HP:0004492) | 2.58269203 |
70 | Hypokalemia (HP:0002900) | 2.57332242 |
71 | Epistaxis (HP:0000421) | 2.54283998 |
72 | Xanthomatosis (HP:0000991) | 2.54268381 |
73 | Renal salt wasting (HP:0000127) | 2.54068104 |
74 | Renal tubular dysfunction (HP:0000124) | 2.53601477 |
75 | Hypophosphatemia (HP:0002148) | 2.51849625 |
76 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.50796142 |
77 | Dicarboxylic aciduria (HP:0003215) | 2.50796142 |
78 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.48977160 |
79 | Symptomatic seizures (HP:0011145) | 2.47263051 |
80 | Hemorrhage of the eye (HP:0011885) | 2.46556519 |
81 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.46355643 |
82 | Abnormality of the common coagulation pathway (HP:0010990) | 2.45956939 |
83 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.45006074 |
84 | Thin bony cortex (HP:0002753) | 2.42816052 |
85 | Abnormal tarsal ossification (HP:0008369) | 2.42673954 |
86 | Nephrolithiasis (HP:0000787) | 2.41484597 |
87 | Rickets (HP:0002748) | 2.41183116 |
88 | Hypercalciuria (HP:0002150) | 2.40671145 |
89 | Hyperglycinemia (HP:0002154) | 2.40176234 |
90 | Fat malabsorption (HP:0002630) | 2.39803172 |
91 | Congenital sensorineural hearing impairment (HP:0008527) | 2.36296856 |
92 | Hypolipoproteinemia (HP:0010981) | 2.36104670 |
93 | Abnormality of macrophages (HP:0004311) | 2.34987792 |
94 | Delayed CNS myelination (HP:0002188) | 2.34832943 |
95 | Nausea (HP:0002018) | 2.34657519 |
96 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.33956247 |
97 | Abnormal enzyme/coenzyme activity (HP:0012379) | 2.32912199 |
98 | Metabolic acidosis (HP:0001942) | 2.29972341 |
99 | Abnormality of alkaline phosphatase activity (HP:0004379) | 2.26976229 |
100 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.24650172 |
101 | Complement deficiency (HP:0004431) | 2.23700977 |
102 | Protuberant abdomen (HP:0001538) | 2.23001970 |
103 | Metaphyseal irregularity (HP:0003025) | 2.20846971 |
104 | Neurofibrillary tangles (HP:0002185) | 2.20431106 |
105 | Late onset (HP:0003584) | 2.18596880 |
106 | Increased mean platelet volume (HP:0011877) | 2.17976713 |
107 | Loss of speech (HP:0002371) | 2.17665288 |
108 | Vomiting (HP:0002013) | 2.17070128 |
109 | Abnormality of the costochondral junction (HP:0000919) | 2.15009200 |
110 | Axonal loss (HP:0003447) | 2.13964541 |
111 | Elevated alkaline phosphatase (HP:0003155) | 2.13760536 |
112 | Vascular calcification (HP:0004934) | 2.13443937 |
113 | Lethargy (HP:0001254) | 2.11189031 |
114 | Mutism (HP:0002300) | 2.11023461 |
115 | Acanthocytosis (HP:0001927) | 2.10279908 |
116 | Conjugated hyperbilirubinemia (HP:0002908) | 2.09092131 |
117 | Abnormal platelet volume (HP:0011876) | 2.07766075 |
118 | Prolonged neonatal jaundice (HP:0006579) | 2.07681555 |
119 | Glomerulonephritis (HP:0000099) | 2.06962125 |
120 | Joint swelling (HP:0001386) | 2.04183263 |
121 | Enlarged epiphyses (HP:0010580) | 2.03304920 |
122 | Irritability (HP:0000737) | 2.02174906 |
123 | Dehydration (HP:0001944) | 2.02145340 |
124 | Impaired platelet aggregation (HP:0003540) | 2.01782949 |
125 | Abnormal platelet function (HP:0011869) | 2.01782949 |
126 | Hypobetalipoproteinemia (HP:0003563) | 2.01766502 |
127 | Petechiae (HP:0000967) | 1.97996801 |
128 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.97407702 |
129 | Abnormality of vitamin metabolism (HP:0100508) | 1.96298463 |
130 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.96084106 |
131 | Epidermoid cyst (HP:0200040) | 1.95876956 |
132 | Abnormality of potassium homeostasis (HP:0011042) | 1.95509967 |
133 | Increased serum ferritin (HP:0003281) | 1.94986903 |
134 | Hepatic necrosis (HP:0002605) | 1.93727382 |
135 | Steatorrhea (HP:0002570) | 1.92647613 |
136 | Eczematoid dermatitis (HP:0000976) | 1.91151876 |
137 | Spontaneous abortion (HP:0005268) | 1.90856952 |
138 | Progressive neurologic deterioration (HP:0002344) | 1.90782686 |
139 | Recurrent bacterial skin infections (HP:0005406) | 1.90727267 |
140 | Abnormality of iron homeostasis (HP:0011031) | 1.90307774 |
141 | Decreased circulating renin level (HP:0003351) | 1.90083188 |
142 | White forelock (HP:0002211) | 1.88180183 |
143 | Pulmonary embolism (HP:0002204) | 1.84182341 |
144 | Orchitis (HP:0100796) | 1.79940147 |
145 | Myocardial infarction (HP:0001658) | 1.77905272 |
146 | Pancreatitis (HP:0001733) | 1.76993400 |
147 | Cardiovascular calcification (HP:0011915) | 1.76236991 |
148 | Hypercholesterolemia (HP:0003124) | 1.74619314 |
149 | Increased CSF protein (HP:0002922) | 1.73822182 |
150 | Patchy hypopigmentation of hair (HP:0011365) | 1.73412231 |
151 | Mitral stenosis (HP:0001718) | 1.72941024 |
152 | Chronic diarrhea (HP:0002028) | 1.71673097 |
153 | Hepatosplenomegaly (HP:0001433) | 1.71523009 |
154 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.71328070 |
Rank | Gene Set | Z-score |
---|---|---|
1 | WNK4 | 4.41432216 |
2 | BCKDK | 3.81249543 |
3 | WNK3 | 3.59693278 |
4 | ERN1 | 3.50762311 |
5 | OXSR1 | 3.33849077 |
6 | ACVR1B | 2.77436797 |
7 | MST1R | 2.74565121 |
8 | FRK | 2.56848862 |
9 | IRAK3 | 2.45791037 |
10 | TAOK3 | 2.36251765 |
11 | INSRR | 2.36145029 |
12 | MAP3K14 | 2.30759288 |
13 | MAPK15 | 2.20161239 |
14 | TGFBR2 | 2.05888329 |
15 | MAP3K3 | 2.03098499 |
16 | TBK1 | 1.96978307 |
17 | TYK2 | 1.95176756 |
18 | TESK1 | 1.94507741 |
19 | MAP4K1 | 1.87227955 |
20 | TESK2 | 1.84133549 |
21 | DDR2 | 1.83300124 |
22 | FLT3 | 1.79902729 |
23 | BMPR2 | 1.73215666 |
24 | MAP2K3 | 1.71376772 |
25 | PDK2 | 1.62377302 |
26 | MST4 | 1.61535837 |
27 | STK10 | 1.59001293 |
28 | STK38L | 1.57755086 |
29 | BLK | 1.55263680 |
30 | MAPKAPK3 | 1.53088497 |
31 | MET | 1.50634881 |
32 | PIM2 | 1.49920778 |
33 | MAP3K2 | 1.46883210 |
34 | TIE1 | 1.37952886 |
35 | MAP3K11 | 1.37572073 |
36 | CSF1R | 1.32483111 |
37 | BTK | 1.30356088 |
38 | MAP4K2 | 1.26810946 |
39 | IRAK4 | 1.26399545 |
40 | MAP2K2 | 1.24429719 |
41 | EPHA3 | 1.24336941 |
42 | MAP3K10 | 1.23907964 |
43 | TEC | 1.23220589 |
44 | GRK5 | 1.22309358 |
45 | FER | 1.20158062 |
46 | IKBKE | 1.16844715 |
47 | MAP2K6 | 1.06625798 |
48 | GRK6 | 1.05460973 |
49 | DAPK1 | 1.05090111 |
50 | FGFR4 | 1.02994133 |
51 | FES | 1.01166003 |
52 | STK39 | 0.96879094 |
53 | FGR | 0.95079057 |
54 | TNK2 | 0.94809624 |
55 | GRK7 | 0.93722395 |
56 | NEK9 | 0.92399687 |
57 | PTK6 | 0.87720596 |
58 | ZAP70 | 0.87052066 |
59 | JAK2 | 0.86905553 |
60 | PIK3CA | 0.86507332 |
61 | KIT | 0.86184733 |
62 | PDK1 | 0.85824388 |
63 | BMPR1B | 0.81755979 |
64 | EPHA4 | 0.81393520 |
65 | PRPF4B | 0.80600675 |
66 | CAMKK2 | 0.79529430 |
67 | LRRK2 | 0.79225982 |
68 | LMTK2 | 0.79015050 |
69 | FGFR3 | 0.78175660 |
70 | ARAF | 0.78121937 |
71 | MAPK11 | 0.77540293 |
72 | JAK3 | 0.76675873 |
73 | PRKG2 | 0.74829809 |
74 | SYK | 0.74490281 |
75 | IKBKB | 0.72400622 |
76 | EPHB2 | 0.70644276 |
77 | MOS | 0.70571296 |
78 | DAPK3 | 0.69306392 |
79 | PRKACG | 0.69173995 |
80 | PASK | 0.68583446 |
81 | RPS6KA4 | 0.67190880 |
82 | CHUK | 0.67070063 |
83 | MAP3K6 | 0.66373399 |
84 | IRAK2 | 0.66264699 |
85 | JAK1 | 0.65759800 |
86 | PRKD3 | 0.65379497 |
87 | PINK1 | 0.65121536 |
88 | RIPK4 | 0.64548433 |
89 | ITK | 0.64459936 |
90 | SGK223 | 0.64454107 |
91 | SGK494 | 0.64454107 |
92 | EPHB1 | 0.64452692 |
93 | EPHA2 | 0.62727552 |
94 | NME2 | 0.62610078 |
95 | CAMK2D | 0.60684432 |
96 | PTK2B | 0.60212043 |
97 | PKN2 | 0.59114806 |
98 | IRAK1 | 0.59111136 |
99 | CAMK2G | 0.58851008 |
100 | CSK | 0.58778273 |
101 | MAP3K1 | 0.58604654 |
102 | NTRK3 | 0.57533441 |
103 | MAP3K5 | 0.57294760 |
104 | CDC42BPA | 0.56723578 |
105 | LIMK1 | 0.56463768 |
106 | ABL2 | 0.56081525 |
107 | MAP3K12 | 0.54856211 |
108 | ERBB4 | 0.53301001 |
109 | ADRBK2 | 0.53198416 |
110 | SRC | 0.52696411 |
111 | SGK2 | 0.52272639 |
112 | TAOK1 | 0.52247896 |
113 | PRKCI | 0.52207991 |
114 | PRKCA | 0.51775425 |
115 | TXK | 0.49632213 |
116 | PTK2 | 0.49380727 |
117 | FYN | 0.49313813 |
118 | PRKAA2 | 0.49164630 |
119 | NME1 | 0.48722633 |
120 | GRK1 | 0.48136181 |
121 | PRKD1 | 0.47765183 |
122 | PRKCD | 0.47665537 |
123 | PHKG1 | 0.47650245 |
124 | PHKG2 | 0.47650245 |
125 | PIK3CG | 0.47277337 |
126 | GSK3A | 0.45367162 |
127 | SGK3 | 0.44871047 |
128 | MATK | 0.44581333 |
129 | TAOK2 | 0.44320191 |
130 | DAPK2 | 0.44285743 |
131 | NEK1 | 0.44031597 |
132 | LYN | 0.41826476 |
133 | MYLK | 0.38858942 |
134 | NLK | 0.38486436 |
135 | ZAK | 0.38195897 |
136 | RIPK1 | 0.37841212 |
137 | PDPK1 | 0.37257211 |
138 | TGFBR1 | 0.36652975 |
139 | BMX | 0.36058913 |
140 | PAK4 | 0.34223688 |
141 | MAP2K1 | 0.33672894 |
142 | HIPK2 | 0.33623242 |
143 | DYRK1B | 0.33421810 |
144 | MAP3K7 | 0.32758493 |
145 | PIM1 | 0.30330279 |
146 | IGF1R | 0.30288740 |
147 | BRAF | 0.30258972 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 4.27626353 |
2 | * Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 3.64196831 |
3 | Sulfur metabolism_Homo sapiens_hsa00920 | 3.10963439 |
4 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.41916275 |
5 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.33513443 |
6 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.31244197 |
7 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.15549611 |
8 | Other glycan degradation_Homo sapiens_hsa00511 | 2.15158214 |
9 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.14496127 |
10 | Peroxisome_Homo sapiens_hsa04146 | 2.11775832 |
11 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.11098542 |
12 | Selenocompound metabolism_Homo sapiens_hsa00450 | 2.08205939 |
13 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.03158115 |
14 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.02904865 |
15 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.01932054 |
16 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.01238176 |
17 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.97122884 |
18 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.91924003 |
19 | Histidine metabolism_Homo sapiens_hsa00340 | 1.90727548 |
20 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.88628531 |
21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.81629573 |
22 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.74122912 |
23 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.72862649 |
24 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.71933347 |
25 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.69260967 |
26 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.67933344 |
27 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.64244659 |
28 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.63462584 |
29 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.61246990 |
30 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.59379238 |
31 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.44103914 |
32 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.39657304 |
33 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.35211457 |
34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.29606498 |
35 | Galactose metabolism_Homo sapiens_hsa00052 | 1.27478832 |
36 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.26091488 |
37 | Sulfur relay system_Homo sapiens_hsa04122 | 1.25256386 |
38 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.23428876 |
39 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.23010201 |
40 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.21885225 |
41 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.20001177 |
42 | Bile secretion_Homo sapiens_hsa04976 | 1.19591535 |
43 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.19110434 |
44 | Lysosome_Homo sapiens_hsa04142 | 1.17074068 |
45 | Asthma_Homo sapiens_hsa05310 | 1.15779925 |
46 | Retinol metabolism_Homo sapiens_hsa00830 | 1.14511972 |
47 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.12116591 |
48 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.11023408 |
49 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.09276099 |
50 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.04432372 |
51 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.03698404 |
52 | Mineral absorption_Homo sapiens_hsa04978 | 1.03583659 |
53 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.03460592 |
54 | Protein export_Homo sapiens_hsa03060 | 0.97924622 |
55 | Carbon metabolism_Homo sapiens_hsa01200 | 0.96847293 |
56 | ABC transporters_Homo sapiens_hsa02010 | 0.94754663 |
57 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.94511899 |
58 | Allograft rejection_Homo sapiens_hsa05330 | 0.93147861 |
59 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.91104746 |
60 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.86772778 |
61 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.85647251 |
62 | Prion diseases_Homo sapiens_hsa05020 | 0.84357871 |
63 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.83554512 |
64 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.81917970 |
65 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.81043398 |
66 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.79120716 |
67 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.78434708 |
68 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.77872709 |
69 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.76976068 |
70 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.75825325 |
71 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.75423799 |
72 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.74310356 |
73 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.72167811 |
74 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.70626109 |
75 | Lysine degradation_Homo sapiens_hsa00310 | 0.63267861 |
76 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.60107496 |
77 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.55679796 |
78 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.55650955 |
79 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.54929914 |
80 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.54917880 |
81 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.54683274 |
82 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.54446031 |
83 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.51396220 |
84 | Legionellosis_Homo sapiens_hsa05134 | 0.51254004 |
85 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.49633628 |
86 | Pertussis_Homo sapiens_hsa05133 | 0.47875998 |
87 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.47372013 |
88 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.42612074 |
89 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.41546147 |
90 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.41457975 |
91 | Phagosome_Homo sapiens_hsa04145 | 0.40101885 |
92 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.38912506 |
93 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.38613540 |
94 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.38394973 |
95 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.38331282 |
96 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.38302183 |
97 | Leishmaniasis_Homo sapiens_hsa05140 | 0.37090501 |
98 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.36873078 |
99 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.36007625 |
100 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.35647237 |
101 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.35507612 |
102 | Platelet activation_Homo sapiens_hsa04611 | 0.32662543 |
103 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.32631868 |
104 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.31129970 |
105 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.29729043 |
106 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.28857857 |
107 | Tuberculosis_Homo sapiens_hsa05152 | 0.28292180 |
108 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.27590550 |
109 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.25076811 |
110 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.24521058 |
111 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.23947777 |
112 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.23198840 |
113 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.20047740 |
114 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.19892938 |
115 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.19417813 |
116 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.17161139 |