CRYL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)6.45160761
2urate metabolic process (GO:0046415)5.88312175
3drug transport (GO:0015893)5.77922351
4glucuronate metabolic process (GO:0019585)5.55997138
5uronic acid metabolic process (GO:0006063)5.55997138
6aminoglycoside antibiotic metabolic process (GO:0030647)5.36747572
7cellular glucuronidation (GO:0052695)5.29784191
8lysine metabolic process (GO:0006553)5.15012913
9lysine catabolic process (GO:0006554)5.15012913
10epoxygenase P450 pathway (GO:0019373)5.05553853
11cysteine metabolic process (GO:0006534)5.01757677
12drug catabolic process (GO:0042737)4.94313207
13xenobiotic catabolic process (GO:0042178)4.75160803
14glyoxylate metabolic process (GO:0046487)4.69464089
15organic cation transport (GO:0015695)4.66664204
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.59150830
17L-phenylalanine metabolic process (GO:0006558)4.59150830
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.46406299
19L-phenylalanine catabolic process (GO:0006559)4.46406299
20renal absorption (GO:0070293)4.45701723
21response to nitrosative stress (GO:0051409)4.40945674
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.38028939
23aromatic amino acid family catabolic process (GO:0009074)4.36120889
24indole-containing compound catabolic process (GO:0042436)4.35256332
25indolalkylamine catabolic process (GO:0046218)4.35256332
26tryptophan catabolic process (GO:0006569)4.35256332
27sulfur amino acid catabolic process (GO:0000098)4.33536420
28exogenous drug catabolic process (GO:0042738)4.31041599
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.30584433
30regulation of cholesterol esterification (GO:0010872)4.26515138
31angiotensin maturation (GO:0002003)4.25540566
32peptide catabolic process (GO:0043171)4.22061073
33flavonoid metabolic process (GO:0009812)4.20393601
34tryptophan metabolic process (GO:0006568)4.15804932
35vitamin D metabolic process (GO:0042359)4.12288667
36toxin transport (GO:1901998)4.04712070
37benzene-containing compound metabolic process (GO:0042537)3.96235904
38aldehyde catabolic process (GO:0046185)3.94753876
39short-chain fatty acid metabolic process (GO:0046459)3.93613375
40valine metabolic process (GO:0006573)3.93596988
41tricarboxylic acid metabolic process (GO:0072350)3.83688795
423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.82359043
43purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.82359043
44amino-acid betaine metabolic process (GO:0006577)3.80257024
45high-density lipoprotein particle remodeling (GO:0034375)3.78640061
46homocysteine metabolic process (GO:0050667)3.76936413
47glutathione derivative metabolic process (GO:1901685)3.73592947
48glutathione derivative biosynthetic process (GO:1901687)3.73592947
49low-density lipoprotein particle remodeling (GO:0034374)3.72942226
50phosphate ion transport (GO:0006817)3.69259208
51positive regulation of triglyceride lipase activity (GO:0061365)3.69015273
52positive regulation of lipoprotein lipase activity (GO:0051006)3.69015273
53L-ascorbic acid metabolic process (GO:0019852)3.65136146
54regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.59772516
55reverse cholesterol transport (GO:0043691)3.59698729
56protein-lipid complex remodeling (GO:0034368)3.59328508
57macromolecular complex remodeling (GO:0034367)3.59328508
58plasma lipoprotein particle remodeling (GO:0034369)3.59328508
59complement activation, alternative pathway (GO:0006957)3.59030060
60quaternary ammonium group transport (GO:0015697)3.58308599
61carnitine metabolic process (GO:0009437)3.54960942
62fatty acid beta-oxidation (GO:0006635)3.54901147
63negative regulation of cholesterol transport (GO:0032375)3.51446411
64negative regulation of sterol transport (GO:0032372)3.51446411
65phenylpropanoid metabolic process (GO:0009698)3.51078162
66phospholipid efflux (GO:0033700)3.49971828
67nitrogen cycle metabolic process (GO:0071941)3.48811202
68nonribosomal peptide biosynthetic process (GO:0019184)3.47780090
69glutathione metabolic process (GO:0006749)3.45494985
70omega-hydroxylase P450 pathway (GO:0097267)3.44001075
71kynurenine metabolic process (GO:0070189)3.43808188
72fatty acid oxidation (GO:0019395)3.42460488
73glycosphingolipid catabolic process (GO:0046479)3.41578514
74branched-chain amino acid metabolic process (GO:0009081)3.38899602
75response to mercury ion (GO:0046689)3.36707174
76lipid oxidation (GO:0034440)3.36296686
77regulation of protein activation cascade (GO:2000257)3.32730817
78glycoside metabolic process (GO:0016137)3.31392623
79cholesterol efflux (GO:0033344)3.30838054
80regulation of triglyceride catabolic process (GO:0010896)3.29738593
81blood coagulation, intrinsic pathway (GO:0007597)3.29693619
82very-low-density lipoprotein particle assembly (GO:0034379)3.28560816
83excretion (GO:0007588)3.26777080
84proline metabolic process (GO:0006560)3.25172956
85cellular modified amino acid catabolic process (GO:0042219)3.24759618
86glucose 6-phosphate metabolic process (GO:0051156)3.23502627
87cellular ketone body metabolic process (GO:0046950)3.21909333
88regulation of complement activation (GO:0030449)3.21069219
89modified amino acid transport (GO:0072337)3.19928815
90serine family amino acid catabolic process (GO:0009071)3.18401999
91glycolipid catabolic process (GO:0019377)3.17981229
92aromatic amino acid family metabolic process (GO:0009072)3.17632987
93glutathione biosynthetic process (GO:0006750)3.17250421
94ethanol oxidation (GO:0006069)3.17236823
95hormone catabolic process (GO:0042447)3.16352214
96negative regulation of fibrinolysis (GO:0051918)3.16348275
97monocarboxylic acid catabolic process (GO:0072329)3.15741021
98bile acid metabolic process (GO:0008206)3.15429098
99bile acid and bile salt transport (GO:0015721)3.14616607
100drug metabolic process (GO:0017144)3.14065562
101fructose metabolic process (GO:0006000)3.13759227
102regulation of fibrinolysis (GO:0051917)3.12675147
103fatty acid catabolic process (GO:0009062)3.12307401
104oligosaccharide catabolic process (GO:0009313)3.11710460
105fat-soluble vitamin biosynthetic process (GO:0042362)3.11444474
106vitamin transport (GO:0051180)3.09002326
107bile acid biosynthetic process (GO:0006699)3.07994022
108fibrinolysis (GO:0042730)3.05669789
109indolalkylamine metabolic process (GO:0006586)3.05438956
110serine family amino acid metabolic process (GO:0009069)3.04171036
111phosphate ion transmembrane transport (GO:0035435)3.04127591
112negative regulation of hemostasis (GO:1900047)3.03794484
113negative regulation of blood coagulation (GO:0030195)3.03794484
114sulfur amino acid metabolic process (GO:0000096)2.99643726
115plasma lipoprotein particle assembly (GO:0034377)2.98649559
116transepithelial transport (GO:0070633)2.97201163
117xenobiotic metabolic process (GO:0006805)2.96363041
118NADH metabolic process (GO:0006734)2.95882164
1192-oxoglutarate metabolic process (GO:0006103)2.95276040
120carboxylic acid catabolic process (GO:0046395)2.95175668
121organic acid catabolic process (GO:0016054)2.95175668
122cellular biogenic amine catabolic process (GO:0042402)2.94848976
123amine catabolic process (GO:0009310)2.94848976
124aspartate family amino acid catabolic process (GO:0009068)2.94824101
125positive regulation of fatty acid biosynthetic process (GO:0045723)2.93073752
126plasma lipoprotein particle organization (GO:0071827)2.92731422
127cellular amino acid catabolic process (GO:0009063)2.92682179
128peptidyl-glutamic acid carboxylation (GO:0017187)2.92262552
129protein carboxylation (GO:0018214)2.92262552
130regulation of cholesterol homeostasis (GO:2000188)2.90495978
131urea cycle (GO:0000050)2.89877446
132urea metabolic process (GO:0019627)2.89877446
133branched-chain amino acid catabolic process (GO:0009083)2.87909580
134protein activation cascade (GO:0072376)2.86766567
135protein-lipid complex subunit organization (GO:0071825)2.85014993
136negative regulation of coagulation (GO:0050819)2.84307531
137protein-lipid complex assembly (GO:0065005)2.83845201
138alpha-amino acid catabolic process (GO:1901606)2.83638747
139ceramide catabolic process (GO:0046514)2.81707849
140ethanol metabolic process (GO:0006067)2.81309351
141signal peptide processing (GO:0006465)2.80408581
142lipoprotein transport (GO:0042953)2.80376200
143polyol transport (GO:0015791)2.80176859
144lipoprotein metabolic process (GO:0042157)2.79508625
145phosphate ion homeostasis (GO:0055062)2.79223848
146trivalent inorganic anion homeostasis (GO:0072506)2.79223848
147triglyceride homeostasis (GO:0070328)2.78045494
148acylglycerol homeostasis (GO:0055090)2.78045494
149intestinal absorption (GO:0050892)2.77212427
150nicotinamide nucleotide biosynthetic process (GO:0019359)2.76833127
151regulation of sterol transport (GO:0032371)2.72310293
152regulation of cholesterol transport (GO:0032374)2.72310293
153complement activation, classical pathway (GO:0006958)2.71843922
154acute-phase response (GO:0006953)2.71110848
155complement activation (GO:0006956)2.66941088
156plasma lipoprotein particle clearance (GO:0034381)2.63912470
157tyrosine metabolic process (GO:0006570)2.60663677
158phospholipid homeostasis (GO:0055091)2.60151302
159arginine metabolic process (GO:0006525)2.58774722
160positive regulation of cellular amine metabolic process (GO:0033240)2.53177833
161alkaloid metabolic process (GO:0009820)2.52650356
162cholesterol homeostasis (GO:0042632)2.52067963
163negative regulation of wound healing (GO:0061045)2.51145307
164neutrophil activation involved in immune response (GO:0002283)2.50578295
165positive regulation of hemostasis (GO:1900048)2.49335778
166positive regulation of blood coagulation (GO:0030194)2.49335778
167arachidonic acid metabolic process (GO:0019369)2.49296640
168cyclooxygenase pathway (GO:0019371)2.47078055
169sterol homeostasis (GO:0055092)2.46007703
170positive regulation of steroid metabolic process (GO:0045940)2.45564965
171regulation of cholesterol metabolic process (GO:0090181)2.45143524
172positive regulation of coagulation (GO:0050820)2.42992145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.96518451
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.39348823
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.93443415
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.23167626
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.01320300
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.91315132
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.68843561
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.94187605
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.85208433
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.72706938
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.70087682
12STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.69218470
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.49603646
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.47555408
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.47168381
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24066483
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20789450
18GATA1_22025678_ChIP-Seq_K562_Human2.12355221
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.09172253
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.08506097
21SOX2_27498859_Chip-Seq_STOMACH_Mouse2.06002157
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05939934
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05262432
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.96814392
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88186071
26* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86871234
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81779686
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72824943
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72445712
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70409729
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68096770
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.60419987
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57599710
34GATA4_25053715_ChIP-Seq_YYC3_Human1.57452510
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45317691
36* SOX2_20726797_ChIP-Seq_SW620_Human1.44614936
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44107134
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.43379824
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43017561
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41373612
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41355380
42TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40470719
43* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40307674
44CLOCK_20551151_ChIP-Seq_293T_Human1.38768201
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36295890
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34791156
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34463284
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33299127
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25284214
50GATA6_25053715_ChIP-Seq_YYC3_Human1.24941778
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24292481
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18957166
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18570579
54GATA1_19941826_ChIP-Seq_K562_Human1.16739614
55SPI1_23127762_ChIP-Seq_K562_Human1.16176486
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15173051
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14790943
58* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12160812
59* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10545551
60SCL_19346495_ChIP-Seq_HPC-7_Human1.10097457
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09310363
62BCL6_27268052_Chip-Seq_Bcells_Human1.08504853
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.06199359
64BCOR_27268052_Chip-Seq_Bcells_Human1.04951464
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.03653091
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02652615
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02635291
68STAT1_20625510_ChIP-Seq_HELA_Human1.01197086
69RACK7_27058665_Chip-Seq_MCF-7_Human1.00404781
70P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99751220
71LXR_22292898_ChIP-Seq_THP-1_Human0.99714824
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99483754
73DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97471949
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97273714
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97083750
76STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95108268
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94931683
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94222464
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93121249
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92945123
81GATA1_19941827_ChIP-Seq_MEL_Mouse0.91831736
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91715530
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90758060
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89753088
85AR_21909140_ChIP-Seq_LNCAP_Human0.89365231
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89358203
87GATA2_19941826_ChIP-Seq_K562_Human0.89091172
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88488713
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88477971
90* SPI1_23547873_ChIP-Seq_NB4_Human0.88007312
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87141992
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86994803
93* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86011622
94DROSHA_22980978_ChIP-Seq_HELA_Human0.85293700
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85278293
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85278293
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84708322
98HTT_18923047_ChIP-ChIP_STHdh_Human0.84165317
99GATA3_26560356_Chip-Seq_TH2_Human0.84088664
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84087801
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84009172
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82924252
103* FOXA2_19822575_ChIP-Seq_HepG2_Human0.82853551
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82844321
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82221429
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82181433
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.81370930
108AR_20517297_ChIP-Seq_VCAP_Human0.80950411
109VDR_24763502_ChIP-Seq_THP-1_Human0.80796213
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80796132
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79892114
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79463859
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79137967
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78978558
115PU_27001747_Chip-Seq_BMDM_Mouse0.78008079
116* SA1_27219007_Chip-Seq_Bcells_Human0.77474858
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77067666
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76978959
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.76406944
120VDR_24787735_ChIP-Seq_THP-1_Human0.76213896
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75634338
122SOX2_21211035_ChIP-Seq_LN229_Human0.75558381
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74269263
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.74248288
125SRF_21415370_ChIP-Seq_HL-1_Mouse0.74089644
126RUNX1_22412390_ChIP-Seq_EML_Mouse0.73206553
127RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72098240
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71899070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.64617774
2MP0002139_abnormal_hepatobiliary_system5.25265540
3MP0008875_abnormal_xenobiotic_pharmacok4.09201368
4MP0004043_abnormal_pH_regulation3.77120463
5MP0005365_abnormal_bile_salt3.36904130
6MP0004019_abnormal_vitamin_homeostasis3.31285315
7MP0003195_calcinosis3.20070027
8MP0005085_abnormal_gallbladder_physiolo3.12384282
9MP0005058_abnormal_lysosome_morphology3.06220074
10MP0005332_abnormal_amino_acid2.99769453
11MP0009643_abnormal_urine_homeostasis2.91195145
12MP0002138_abnormal_hepatobiliary_system2.56584252
13MP0003252_abnormal_bile_duct2.48661798
14MP0009840_abnormal_foam_cell2.43406717
15MP0001666_abnormal_nutrient_absorption2.31991501
16MP0003303_peritoneal_inflammation2.31689145
17MP0005636_abnormal_mineral_homeostasis2.18023553
18MP0003186_abnormal_redox_activity2.13338238
19MP0001765_abnormal_ion_homeostasis2.12762758
20MP0003191_abnormal_cellular_cholesterol2.06062681
21MP0001756_abnormal_urination1.99180298
22MP0003806_abnormal_nucleotide_metabolis1.89024307
23MP0002136_abnormal_kidney_physiology1.87520244
24MP0000678_abnormal_parathyroid_gland1.86052655
25MP0010329_abnormal_lipoprotein_level1.83314696
26MP0003879_abnormal_hair_cell1.73463423
27MP0002876_abnormal_thyroid_physiology1.66228765
28MP0003868_abnormal_feces_composition1.62910537
29MP0001835_abnormal_antigen_presentation1.62111466
30MP0005167_abnormal_blood-brain_barrier1.61792282
31MP0005319_abnormal_enzyme/_coenzyme1.61564077
32MP0003724_increased_susceptibility_to1.59528455
33MP0001764_abnormal_homeostasis1.54134781
34MP0003183_abnormal_peptide_metabolism1.50259270
35MP0003329_amyloid_beta_deposits1.42741849
36MP0004264_abnormal_extraembryonic_tissu1.42267126
37MP0003300_gastrointestinal_ulcer1.40827120
38MP0000538_abnormal_urinary_bladder1.38153953
39MP0005584_abnormal_enzyme/coenzyme_acti1.33729477
40MP0003436_decreased_susceptibility_to1.33059642
41MP0006082_CNS_inflammation1.30998419
42MP0000343_altered_response_to1.30665822
43MP0000609_abnormal_liver_physiology1.28221324
44MP0009764_decreased_sensitivity_to1.25405203
45MP0008469_abnormal_protein_level1.23961756
46MP0003172_abnormal_lysosome_physiology1.23380043
47MP0002118_abnormal_lipid_homeostasis1.22622127
48MP0003878_abnormal_ear_physiology1.17406476
49MP0005377_hearing/vestibular/ear_phenot1.17406476
50MP0005451_abnormal_body_composition1.16756541
51MP0005310_abnormal_salivary_gland1.12641930
52MP0010155_abnormal_intestine_physiology1.11552045
53MP0002928_abnormal_bile_duct1.11057689
54MP0002254_reproductive_system_inflammat1.08895099
55MP0002148_abnormal_hypersensitivity_rea1.08468424
56MP0000920_abnormal_myelination1.03895611
57MP0001845_abnormal_inflammatory_respons1.03175837
58MP0005464_abnormal_platelet_physiology1.00684315
59MP0005408_hypopigmentation1.00368459
60MP0003075_altered_response_to1.00366538
61MP0001790_abnormal_immune_system0.99660527
62MP0005387_immune_system_phenotype0.99660527
63MP0001501_abnormal_sleep_pattern0.99117757
64MP0001663_abnormal_digestive_system0.97758190
65MP0002419_abnormal_innate_immunity0.96536634
66MP0000465_gastrointestinal_hemorrhage0.96347052
67MP0002971_abnormal_brown_adipose0.96013747
68MP0006036_abnormal_mitochondrial_physio0.94744505
69MP0009642_abnormal_blood_homeostasis0.93753280
70MP0008260_abnormal_autophagy0.93459137
71MP0005165_increased_susceptibility_to0.91794677
72MP0004782_abnormal_surfactant_physiolog0.91374943
73MP0004510_myositis0.89998194
74MP0010234_abnormal_vibrissa_follicle0.89033901
75MP0005084_abnormal_gallbladder_morpholo0.87692616
76MP0005166_decreased_susceptibility_to0.87640044
77MP0000230_abnormal_systemic_arterial0.86496242
78MP0001664_abnormal_digestion0.86175780
79MP0005535_abnormal_body_temperature0.85072998
80MP0005025_abnormal_response_to0.84335579
81MP0000249_abnormal_blood_vessel0.84046036
82MP0003866_abnormal_defecation0.82676139
83MP0005000_abnormal_immune_tolerance0.82142939
84MP0000598_abnormal_liver_morphology0.81921659
85MP0009785_altered_susceptibility_to0.80811685
86MP0001533_abnormal_skeleton_physiology0.79689934
87MP0005381_digestive/alimentary_phenotyp0.79317129
88MP0002998_abnormal_bone_remodeling0.79165797
89MP0002135_abnormal_kidney_morphology0.78150564
90MP0005670_abnormal_white_adipose0.78054803
91MP0004147_increased_porphyrin_level0.75893845
92MP0005448_abnormal_energy_balance0.75304196
93MP0004947_skin_inflammation0.73494346
94MP0005220_abnormal_exocrine_pancreas0.73386575
95MP0002723_abnormal_immune_serum0.72580975
96MP0003638_abnormal_response/metabolism_0.72349374
97MP0002877_abnormal_melanocyte_morpholog0.72121468
98MP0002078_abnormal_glucose_homeostasis0.71670169
99MP0001958_emphysema0.71204765
100MP0002896_abnormal_bone_mineralization0.70823976
101MP0000604_amyloidosis0.70363990
102MP0008874_decreased_physiological_sensi0.69685723
103MP0008961_abnormal_basal_metabolism0.68981928
104MP0000685_abnormal_immune_system0.68535370
105MP0009379_abnormal_foot_pigmentation0.67938951
106MP0002909_abnormal_adrenal_gland0.67425297
107MP0003633_abnormal_nervous_system0.66752336
108MP0002405_respiratory_system_inflammati0.66533539
109MP0001873_stomach_inflammation0.65952277
110MP0009763_increased_sensitivity_to0.65562106
111MP0002132_abnormal_respiratory_system0.65454606
112MP0002098_abnormal_vibrissa_morphology0.65032343
113MP0002693_abnormal_pancreas_physiology0.65020428
114MP0003690_abnormal_glial_cell0.63892375
115MP0001545_abnormal_hematopoietic_system0.63762885
116MP0005397_hematopoietic_system_phenotyp0.63762885
117MP0005409_darkened_coat_color0.63473429
118MP0010386_abnormal_urinary_bladder0.62400872
119MP0002452_abnormal_antigen_presenting0.62368307
120MP0009765_abnormal_xenobiotic_induced0.62294277
121MP0001800_abnormal_humoral_immune0.61502468
122MP0003656_abnormal_erythrocyte_physiolo0.61240636
123MP0009780_abnormal_chondrocyte_physiolo0.60834391
124MP0005671_abnormal_response_to0.60686718
125MP0008004_abnormal_stomach_pH0.60461658
126MP0008872_abnormal_physiological_respon0.60178319
127MP0003011_delayed_dark_adaptation0.59230300

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)5.38298938
2Hyperactive renin-angiotensin system (HP:0000841)4.54125722
3Metabolic alkalosis (HP:0200114)4.43107286
4Gout (HP:0001997)4.41006411
5Abnormality of glutamine family amino acid metabolism (HP:0010902)4.22512614
6Proximal tubulopathy (HP:0000114)4.17060050
7Hypokalemic alkalosis (HP:0001949)4.06151702
8Purpura (HP:0000979)4.05741249
9Abnormality of chloride homeostasis (HP:0011422)4.02523877
10Abnormality of complement system (HP:0005339)4.01358966
11Increased circulating renin level (HP:0000848)4.00047023
12Hyperglycinuria (HP:0003108)3.96404546
13Deep venous thrombosis (HP:0002625)3.94786341
14Abnormality of magnesium homeostasis (HP:0004921)3.84706193
15Hyperlipoproteinemia (HP:0010980)3.78976211
16Polyuria (HP:0000103)3.76877035
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.74492521
18Vacuolated lymphocytes (HP:0001922)3.74378652
19Systemic lupus erythematosus (HP:0002725)3.71307220
20Abnormality of glycolipid metabolism (HP:0010969)3.68668094
21Abnormality of liposaccharide metabolism (HP:0010968)3.68668094
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.68668094
23Abnormality of purine metabolism (HP:0004352)3.67556834
24Abnormal urine output (HP:0012590)3.66285908
25Dysostosis multiplex (HP:0000943)3.55125730
26Hypomagnesemia (HP:0002917)3.54782666
27Glycosuria (HP:0003076)3.53656181
28Abnormality of urine glucose concentration (HP:0011016)3.53656181
29Abnormality of renal excretion (HP:0011036)3.49467440
30Alkalosis (HP:0001948)3.47658493
31Renal tubular acidosis (HP:0001947)3.46530593
32Ketoacidosis (HP:0001993)3.43162040
33Abnormality of fatty-acid metabolism (HP:0004359)3.39079341
34Mucopolysacchariduria (HP:0008155)3.39042396
35Urinary glycosaminoglycan excretion (HP:0003541)3.39042396
36Abnormal drinking behavior (HP:0030082)3.30070617
37Polydipsia (HP:0001959)3.30070617
38Joint hemorrhage (HP:0005261)3.20775437
39Abnormality of renin-angiotensin system (HP:0000847)3.16227149
40Abnormality of mucopolysaccharide metabolism (HP:0011020)3.15979714
41Abnormality of polysaccharide metabolism (HP:0011012)3.15979714
42Abnormality of glycosaminoglycan metabolism (HP:0004371)3.15979714
43Abnormality of glycine metabolism (HP:0010895)3.14274778
44Abnormality of serine family amino acid metabolism (HP:0010894)3.14274778
45Ketosis (HP:0001946)3.12754473
46Increased purine levels (HP:0004368)3.11595110
47Hyperuricemia (HP:0002149)3.11595110
48Abnormality of monocarboxylic acid metabolism (HP:0010996)3.06865968
49Abnormality of nucleobase metabolism (HP:0010932)3.02832020
50Hyperphosphaturia (HP:0003109)3.01788906
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.99185048
52Prolonged partial thromboplastin time (HP:0003645)2.97267215
53Gingival bleeding (HP:0000225)2.96597032
54Tetany (HP:0001281)2.87938633
55Hypoglycemic coma (HP:0001325)2.85619363
56Menorrhagia (HP:0000132)2.83958610
57Hyperaldosteronism (HP:0000859)2.82883823
58Delayed epiphyseal ossification (HP:0002663)2.79144808
59Hyperammonemia (HP:0001987)2.78977397
60Prolonged bleeding time (HP:0003010)2.70042544
61Intrahepatic cholestasis (HP:0001406)2.69928472
62Hydroxyprolinuria (HP:0003080)2.67542264
63Abnormality of proline metabolism (HP:0010907)2.67542264
64Amyloidosis (HP:0011034)2.65618007
65Malnutrition (HP:0004395)2.63114999
66Nephritis (HP:0000123)2.61951114
67Increased cerebral lipofuscin (HP:0011813)2.61061939
68Abnormal urine phosphate concentration (HP:0012599)2.59158298
69Widely patent fontanelles and sutures (HP:0004492)2.58269203
70Hypokalemia (HP:0002900)2.57332242
71Epistaxis (HP:0000421)2.54283998
72Xanthomatosis (HP:0000991)2.54268381
73Renal salt wasting (HP:0000127)2.54068104
74Renal tubular dysfunction (HP:0000124)2.53601477
75Hypophosphatemia (HP:0002148)2.51849625
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50796142
77Dicarboxylic aciduria (HP:0003215)2.50796142
78Abnormality of sulfur amino acid metabolism (HP:0004339)2.48977160
79Symptomatic seizures (HP:0011145)2.47263051
80Hemorrhage of the eye (HP:0011885)2.46556519
81Recurrent gram-negative bacterial infections (HP:0005420)2.46355643
82Abnormality of the common coagulation pathway (HP:0010990)2.45956939
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45006074
84Thin bony cortex (HP:0002753)2.42816052
85Abnormal tarsal ossification (HP:0008369)2.42673954
86Nephrolithiasis (HP:0000787)2.41484597
87Rickets (HP:0002748)2.41183116
88Hypercalciuria (HP:0002150)2.40671145
89Hyperglycinemia (HP:0002154)2.40176234
90Fat malabsorption (HP:0002630)2.39803172
91Congenital sensorineural hearing impairment (HP:0008527)2.36296856
92Hypolipoproteinemia (HP:0010981)2.36104670
93Abnormality of macrophages (HP:0004311)2.34987792
94Delayed CNS myelination (HP:0002188)2.34832943
95Nausea (HP:0002018)2.34657519
96Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33956247
97Abnormal enzyme/coenzyme activity (HP:0012379)2.32912199
98Metabolic acidosis (HP:0001942)2.29972341
99Abnormality of alkaline phosphatase activity (HP:0004379)2.26976229
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.24650172
101Complement deficiency (HP:0004431)2.23700977
102Protuberant abdomen (HP:0001538)2.23001970
103Metaphyseal irregularity (HP:0003025)2.20846971
104Neurofibrillary tangles (HP:0002185)2.20431106
105Late onset (HP:0003584)2.18596880
106Increased mean platelet volume (HP:0011877)2.17976713
107Loss of speech (HP:0002371)2.17665288
108Vomiting (HP:0002013)2.17070128
109Abnormality of the costochondral junction (HP:0000919)2.15009200
110Axonal loss (HP:0003447)2.13964541
111Elevated alkaline phosphatase (HP:0003155)2.13760536
112Vascular calcification (HP:0004934)2.13443937
113Lethargy (HP:0001254)2.11189031
114Mutism (HP:0002300)2.11023461
115Acanthocytosis (HP:0001927)2.10279908
116Conjugated hyperbilirubinemia (HP:0002908)2.09092131
117Abnormal platelet volume (HP:0011876)2.07766075
118Prolonged neonatal jaundice (HP:0006579)2.07681555
119Glomerulonephritis (HP:0000099)2.06962125
120Joint swelling (HP:0001386)2.04183263
121Enlarged epiphyses (HP:0010580)2.03304920
122Irritability (HP:0000737)2.02174906
123Dehydration (HP:0001944)2.02145340
124Impaired platelet aggregation (HP:0003540)2.01782949
125Abnormal platelet function (HP:0011869)2.01782949
126Hypobetalipoproteinemia (HP:0003563)2.01766502
127Petechiae (HP:0000967)1.97996801
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97407702
129Abnormality of vitamin metabolism (HP:0100508)1.96298463
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96084106
131Epidermoid cyst (HP:0200040)1.95876956
132Abnormality of potassium homeostasis (HP:0011042)1.95509967
133Increased serum ferritin (HP:0003281)1.94986903
134Hepatic necrosis (HP:0002605)1.93727382
135Steatorrhea (HP:0002570)1.92647613
136Eczematoid dermatitis (HP:0000976)1.91151876
137Spontaneous abortion (HP:0005268)1.90856952
138Progressive neurologic deterioration (HP:0002344)1.90782686
139Recurrent bacterial skin infections (HP:0005406)1.90727267
140Abnormality of iron homeostasis (HP:0011031)1.90307774
141Decreased circulating renin level (HP:0003351)1.90083188
142White forelock (HP:0002211)1.88180183
143Pulmonary embolism (HP:0002204)1.84182341
144Orchitis (HP:0100796)1.79940147
145Myocardial infarction (HP:0001658)1.77905272
146Pancreatitis (HP:0001733)1.76993400
147Cardiovascular calcification (HP:0011915)1.76236991
148Hypercholesterolemia (HP:0003124)1.74619314
149Increased CSF protein (HP:0002922)1.73822182
150Patchy hypopigmentation of hair (HP:0011365)1.73412231
151Mitral stenosis (HP:0001718)1.72941024
152Chronic diarrhea (HP:0002028)1.71673097
153Hepatosplenomegaly (HP:0001433)1.71523009
154Abnormality of transition element cation homeostasis (HP:0011030)1.71328070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.41432216
2BCKDK3.81249543
3WNK33.59693278
4ERN13.50762311
5OXSR13.33849077
6ACVR1B2.77436797
7MST1R2.74565121
8FRK2.56848862
9IRAK32.45791037
10TAOK32.36251765
11INSRR2.36145029
12MAP3K142.30759288
13MAPK152.20161239
14TGFBR22.05888329
15MAP3K32.03098499
16TBK11.96978307
17TYK21.95176756
18TESK11.94507741
19MAP4K11.87227955
20TESK21.84133549
21DDR21.83300124
22FLT31.79902729
23BMPR21.73215666
24MAP2K31.71376772
25PDK21.62377302
26MST41.61535837
27STK101.59001293
28STK38L1.57755086
29BLK1.55263680
30MAPKAPK31.53088497
31MET1.50634881
32PIM21.49920778
33MAP3K21.46883210
34TIE11.37952886
35MAP3K111.37572073
36CSF1R1.32483111
37BTK1.30356088
38MAP4K21.26810946
39IRAK41.26399545
40MAP2K21.24429719
41EPHA31.24336941
42MAP3K101.23907964
43TEC1.23220589
44GRK51.22309358
45FER1.20158062
46IKBKE1.16844715
47MAP2K61.06625798
48GRK61.05460973
49DAPK11.05090111
50FGFR41.02994133
51FES1.01166003
52STK390.96879094
53FGR0.95079057
54TNK20.94809624
55GRK70.93722395
56NEK90.92399687
57PTK60.87720596
58ZAP700.87052066
59JAK20.86905553
60PIK3CA0.86507332
61KIT0.86184733
62PDK10.85824388
63BMPR1B0.81755979
64EPHA40.81393520
65PRPF4B0.80600675
66CAMKK20.79529430
67LRRK20.79225982
68LMTK20.79015050
69FGFR30.78175660
70ARAF0.78121937
71MAPK110.77540293
72JAK30.76675873
73PRKG20.74829809
74SYK0.74490281
75IKBKB0.72400622
76EPHB20.70644276
77MOS0.70571296
78DAPK30.69306392
79PRKACG0.69173995
80PASK0.68583446
81RPS6KA40.67190880
82CHUK0.67070063
83MAP3K60.66373399
84IRAK20.66264699
85JAK10.65759800
86PRKD30.65379497
87PINK10.65121536
88RIPK40.64548433
89ITK0.64459936
90SGK2230.64454107
91SGK4940.64454107
92EPHB10.64452692
93EPHA20.62727552
94NME20.62610078
95CAMK2D0.60684432
96PTK2B0.60212043
97PKN20.59114806
98IRAK10.59111136
99CAMK2G0.58851008
100CSK0.58778273
101MAP3K10.58604654
102NTRK30.57533441
103MAP3K50.57294760
104CDC42BPA0.56723578
105LIMK10.56463768
106ABL20.56081525
107MAP3K120.54856211
108ERBB40.53301001
109ADRBK20.53198416
110SRC0.52696411
111SGK20.52272639
112TAOK10.52247896
113PRKCI0.52207991
114PRKCA0.51775425
115TXK0.49632213
116PTK20.49380727
117FYN0.49313813
118PRKAA20.49164630
119NME10.48722633
120GRK10.48136181
121PRKD10.47765183
122PRKCD0.47665537
123PHKG10.47650245
124PHKG20.47650245
125PIK3CG0.47277337
126GSK3A0.45367162
127SGK30.44871047
128MATK0.44581333
129TAOK20.44320191
130DAPK20.44285743
131NEK10.44031597
132LYN0.41826476
133MYLK0.38858942
134NLK0.38486436
135ZAK0.38195897
136RIPK10.37841212
137PDPK10.37257211
138TGFBR10.36652975
139BMX0.36058913
140PAK40.34223688
141MAP2K10.33672894
142HIPK20.33623242
143DYRK1B0.33421810
144MAP3K70.32758493
145PIM10.30330279
146IGF1R0.30288740
147BRAF0.30258972

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.27626353
2* Pentose and glucuronate interconversions_Homo sapiens_hsa000403.64196831
3Sulfur metabolism_Homo sapiens_hsa009203.10963439
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.41916275
5Butanoate metabolism_Homo sapiens_hsa006502.33513443
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31244197
7Fatty acid degradation_Homo sapiens_hsa000712.15549611
8Other glycan degradation_Homo sapiens_hsa005112.15158214
9Tryptophan metabolism_Homo sapiens_hsa003802.14496127
10Peroxisome_Homo sapiens_hsa041462.11775832
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.11098542
12Selenocompound metabolism_Homo sapiens_hsa004502.08205939
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03158115
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.02904865
15Chemical carcinogenesis_Homo sapiens_hsa052042.01932054
16Starch and sucrose metabolism_Homo sapiens_hsa005002.01238176
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.97122884
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91924003
19Histidine metabolism_Homo sapiens_hsa003401.90727548
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.88628531
21Propanoate metabolism_Homo sapiens_hsa006401.81629573
22Folate biosynthesis_Homo sapiens_hsa007901.74122912
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.72862649
24beta-Alanine metabolism_Homo sapiens_hsa004101.71933347
25Glutathione metabolism_Homo sapiens_hsa004801.69260967
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.67933344
27Vitamin digestion and absorption_Homo sapiens_hsa049771.64244659
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63462584
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.61246990
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59379238
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44103914
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39657304
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35211457
34Pyruvate metabolism_Homo sapiens_hsa006201.29606498
35Galactose metabolism_Homo sapiens_hsa000521.27478832
36Staphylococcus aureus infection_Homo sapiens_hsa051501.26091488
37Sulfur relay system_Homo sapiens_hsa041221.25256386
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23428876
39Collecting duct acid secretion_Homo sapiens_hsa049661.23010201
40Arginine biosynthesis_Homo sapiens_hsa002201.21885225
41Fatty acid metabolism_Homo sapiens_hsa012121.20001177
42Bile secretion_Homo sapiens_hsa049761.19591535
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19110434
44Lysosome_Homo sapiens_hsa041421.17074068
45Asthma_Homo sapiens_hsa053101.15779925
46Retinol metabolism_Homo sapiens_hsa008301.14511972
47PPAR signaling pathway_Homo sapiens_hsa033201.12116591
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11023408
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09276099
50Caffeine metabolism_Homo sapiens_hsa002321.04432372
51Phenylalanine metabolism_Homo sapiens_hsa003601.03698404
52Mineral absorption_Homo sapiens_hsa049781.03583659
53Arginine and proline metabolism_Homo sapiens_hsa003301.03460592
54Protein export_Homo sapiens_hsa030600.97924622
55Carbon metabolism_Homo sapiens_hsa012000.96847293
56ABC transporters_Homo sapiens_hsa020100.94754663
57Complement and coagulation cascades_Homo sapiens_hsa046100.94511899
58Allograft rejection_Homo sapiens_hsa053300.93147861
59Fructose and mannose metabolism_Homo sapiens_hsa000510.91104746
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86772778
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85647251
62Prion diseases_Homo sapiens_hsa050200.84357871
63Renin-angiotensin system_Homo sapiens_hsa046140.83554512
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81917970
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81043398
66Type I diabetes mellitus_Homo sapiens_hsa049400.79120716
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.78434708
68Graft-versus-host disease_Homo sapiens_hsa053320.77872709
69Pentose phosphate pathway_Homo sapiens_hsa000300.76976068
70Autoimmune thyroid disease_Homo sapiens_hsa053200.75825325
71Arachidonic acid metabolism_Homo sapiens_hsa005900.75423799
72Fat digestion and absorption_Homo sapiens_hsa049750.74310356
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72167811
74Nitrogen metabolism_Homo sapiens_hsa009100.70626109
75Lysine degradation_Homo sapiens_hsa003100.63267861
76One carbon pool by folate_Homo sapiens_hsa006700.60107496
77Oxidative phosphorylation_Homo sapiens_hsa001900.55679796
78* Metabolic pathways_Homo sapiens_hsa011000.55650955
79Protein digestion and absorption_Homo sapiens_hsa049740.54929914
80Biosynthesis of amino acids_Homo sapiens_hsa012300.54917880
81Glycerolipid metabolism_Homo sapiens_hsa005610.54683274
82Tyrosine metabolism_Homo sapiens_hsa003500.54446031
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51396220
84Legionellosis_Homo sapiens_hsa051340.51254004
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49633628
86Pertussis_Homo sapiens_hsa051330.47875998
87Vitamin B6 metabolism_Homo sapiens_hsa007500.47372013
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42612074
89Vibrio cholerae infection_Homo sapiens_hsa051100.41546147
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41457975
91Phagosome_Homo sapiens_hsa041450.40101885
92Rheumatoid arthritis_Homo sapiens_hsa053230.38912506
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38613540
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.38394973
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38331282
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38302183
97Leishmaniasis_Homo sapiens_hsa051400.37090501
98Linoleic acid metabolism_Homo sapiens_hsa005910.36873078
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.36007625
100Ether lipid metabolism_Homo sapiens_hsa005650.35647237
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35507612
102Platelet activation_Homo sapiens_hsa046110.32662543
103Fatty acid elongation_Homo sapiens_hsa000620.32631868
104African trypanosomiasis_Homo sapiens_hsa051430.31129970
105Pancreatic secretion_Homo sapiens_hsa049720.29729043
106Osteoclast differentiation_Homo sapiens_hsa043800.28857857
107Tuberculosis_Homo sapiens_hsa051520.28292180
108N-Glycan biosynthesis_Homo sapiens_hsa005100.27590550
109Sphingolipid metabolism_Homo sapiens_hsa006000.25076811
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24521058
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23947777
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23198840
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20047740
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19892938
115Steroid biosynthesis_Homo sapiens_hsa001000.19417813
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17161139

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