CRYM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.86064195
2sodium ion export (GO:0071436)5.41865221
3protein localization to synapse (GO:0035418)4.98281775
4ionotropic glutamate receptor signaling pathway (GO:0035235)4.97127789
5vocalization behavior (GO:0071625)4.91984238
6L-amino acid import (GO:0043092)4.88574689
7regulation of glutamate secretion (GO:0014048)4.78337541
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.77656872
9regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.75950705
10regulation of long-term neuronal synaptic plasticity (GO:0048169)4.73421836
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.72485765
12glutamate receptor signaling pathway (GO:0007215)4.69107819
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.64026628
14behavioral defense response (GO:0002209)4.61766755
15behavioral fear response (GO:0001662)4.61766755
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.47337672
17positive regulation of neurotransmitter secretion (GO:0001956)4.46503557
18synaptic vesicle endocytosis (GO:0048488)4.42041570
19exploration behavior (GO:0035640)4.40021904
20regulation of female receptivity (GO:0045924)4.39076675
21synaptic vesicle exocytosis (GO:0016079)4.38324297
22neurotransmitter transport (GO:0006836)4.36104809
23fear response (GO:0042596)4.31821328
24regulation of glutamate receptor signaling pathway (GO:1900449)4.31783185
25locomotory exploration behavior (GO:0035641)4.30961154
26long-term synaptic potentiation (GO:0060291)4.29741668
27synaptic transmission, dopaminergic (GO:0001963)4.26074018
28behavioral response to cocaine (GO:0048148)4.23309518
29cerebellar granule cell differentiation (GO:0021707)4.22254097
30regulation of neuronal synaptic plasticity (GO:0048168)4.22236474
31neuron-neuron synaptic transmission (GO:0007270)4.15659159
32neuron recognition (GO:0008038)4.13607171
33synaptic transmission, glutamatergic (GO:0035249)4.11974729
34regulation of voltage-gated calcium channel activity (GO:1901385)4.08846902
35amino acid import (GO:0043090)4.07930652
36potassium ion homeostasis (GO:0055075)4.07699303
37regulation of dendritic spine morphogenesis (GO:0061001)4.07471020
38female mating behavior (GO:0060180)4.06673905
39neuron cell-cell adhesion (GO:0007158)4.03018867
40neurotransmitter uptake (GO:0001504)4.01918229
41cell communication by electrical coupling (GO:0010644)4.00356789
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.99414771
43regulation of neurotransmitter secretion (GO:0046928)3.98761485
44positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94398642
45regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.92131523
46regulation of neurotransmitter levels (GO:0001505)3.89567545
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.84694736
48regulation of synaptic plasticity (GO:0048167)3.84577609
49dendritic spine organization (GO:0097061)3.79049867
50negative regulation of dendrite morphogenesis (GO:0050774)3.77432012
51regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.73029173
52regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.73029173
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72713974
54regulation of postsynaptic membrane potential (GO:0060078)3.71189106
55positive regulation of synapse maturation (GO:0090129)3.69548456
56postsynaptic membrane organization (GO:0001941)3.69489660
57glutamate secretion (GO:0014047)3.66890127
58long-term memory (GO:0007616)3.65995375
59positive regulation of neurotransmitter transport (GO:0051590)3.63505367
60dendritic spine morphogenesis (GO:0060997)3.61405618
61negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.61285792
62regulation of cell communication by electrical coupling (GO:0010649)3.61263738
63layer formation in cerebral cortex (GO:0021819)3.60969640
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.58996864
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.58786946
66cell communication involved in cardiac conduction (GO:0086065)3.58362801
67potassium ion import (GO:0010107)3.56664539
68positive regulation of cellular response to oxidative stress (GO:1900409)3.56077338
69positive regulation of response to oxidative stress (GO:1902884)3.56077338
70regulation of neurotransmitter uptake (GO:0051580)3.55679743
71response to histamine (GO:0034776)3.54270138
72regulation of neurotransmitter transport (GO:0051588)3.53208830
73cellular sodium ion homeostasis (GO:0006883)3.52958165
74regulation of amyloid precursor protein catabolic process (GO:1902991)3.48516044
75axonal fasciculation (GO:0007413)3.48387252
76regulation of synaptic vesicle exocytosis (GO:2000300)3.48378943
77positive regulation of dendritic spine development (GO:0060999)3.47444821
78regulation of dopamine metabolic process (GO:0042053)3.46799149
79regulation of catecholamine metabolic process (GO:0042069)3.46799149
80neurotransmitter-gated ion channel clustering (GO:0072578)3.46296190
81cellular potassium ion homeostasis (GO:0030007)3.44180117
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.44124478
83regulation of dendritic spine development (GO:0060998)3.43286660
84regulation of Rac GTPase activity (GO:0032314)3.43095229
85vesicle docking involved in exocytosis (GO:0006904)3.42034228
86positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.41585226
87membrane depolarization during action potential (GO:0086010)3.38873086
88G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.38254253
89regulation of vesicle fusion (GO:0031338)3.38177764
90innervation (GO:0060384)3.36715554
91negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.36531460
92regulation of synapse structural plasticity (GO:0051823)3.35387737
93negative regulation of amine transport (GO:0051953)3.34496989
94negative regulation of neurotransmitter transport (GO:0051589)3.33210514
95cochlea development (GO:0090102)3.31324867
96neuromuscular process controlling posture (GO:0050884)3.31290416
97synaptic vesicle docking involved in exocytosis (GO:0016081)3.31062265
98transmission of nerve impulse (GO:0019226)3.30993317
99regulation of synaptic vesicle transport (GO:1902803)3.28938721
100learning (GO:0007612)3.27786993
101regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.27465994
102negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26543398
103membrane depolarization (GO:0051899)3.26378770
104vesicle docking (GO:0048278)3.24268050
105acidic amino acid transport (GO:0015800)3.23797180
106regulation of sodium ion transmembrane transporter activity (GO:2000649)3.22438207
107phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.21491786
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20865939
109neuronal ion channel clustering (GO:0045161)3.20768672
110negative regulation of amino acid transport (GO:0051956)3.20173601
111neuromuscular process controlling balance (GO:0050885)3.20125432
112neuronal action potential propagation (GO:0019227)3.19088913
113regulation of inositol phosphate biosynthetic process (GO:0010919)3.18176555
114regulation of synapse maturation (GO:0090128)3.16548890
115proline transport (GO:0015824)3.15864543
116regulation of synaptic transmission, glutamatergic (GO:0051966)3.15561528
117synaptic transmission (GO:0007268)3.15420687
118regulation of synaptic transmission (GO:0050804)3.13840616
119regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.13097530
120presynaptic membrane assembly (GO:0097105)3.12995035
121long term synaptic depression (GO:0060292)3.11959784
122positive regulation of membrane potential (GO:0045838)3.11347888
123glycosphingolipid biosynthetic process (GO:0006688)3.10857966
124establishment of synaptic vesicle localization (GO:0097480)3.10360511
125synaptic vesicle transport (GO:0048489)3.10360511
126inner ear receptor cell development (GO:0060119)3.09689113
127positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.09135866
128activation of protein kinase A activity (GO:0034199)3.09065226
129gamma-aminobutyric acid transport (GO:0015812)3.08322181
130response to amphetamine (GO:0001975)3.08067240
131synaptic vesicle maturation (GO:0016188)3.07750834
132positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.06562517
133regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.06451641
134dopamine transport (GO:0015872)3.05554643
135vesicle transport along microtubule (GO:0047496)3.05224702
136positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.04137382
137extracellular fibril organization (GO:0043206)3.03845641
138regulation of sodium ion transmembrane transport (GO:1902305)3.03409281
139regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.03313398
140neurotransmitter secretion (GO:0007269)3.01086263
141ephrin receptor signaling pathway (GO:0048013)3.00495501
142calcium-mediated signaling using intracellular calcium source (GO:0035584)2.99476632
143dicarboxylic acid transport (GO:0006835)2.95914184
144negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95334891
145L-glutamate transport (GO:0015813)2.94618992
146detection of calcium ion (GO:0005513)2.94431959
147positive regulation of synaptic transmission (GO:0050806)2.93685290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95049475
2GBX2_23144817_ChIP-Seq_PC3_Human3.80716979
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.49865779
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.47377871
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.44568456
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse3.10927788
7JARID2_20075857_ChIP-Seq_MESCs_Mouse3.02534545
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.96461961
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.96461961
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.94005738
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.79460302
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.75953253
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.74958806
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.66225356
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.63089642
16REST_21632747_ChIP-Seq_MESCs_Mouse2.62623273
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.58268550
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51489825
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.30048285
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29627899
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.27774959
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20918016
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.10549881
24* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99167588
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87618262
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87198287
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85419921
28SMAD4_21799915_ChIP-Seq_A2780_Human1.80524370
29DROSHA_22980978_ChIP-Seq_HELA_Human1.76237604
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75213076
31TAF15_26573619_Chip-Seq_HEK293_Human1.74594463
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.74196521
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73386162
34AR_21572438_ChIP-Seq_LNCaP_Human1.72253929
35FUS_26573619_Chip-Seq_HEK293_Human1.71856839
36VDR_22108803_ChIP-Seq_LS180_Human1.69262139
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.68647492
38P300_19829295_ChIP-Seq_ESCs_Human1.66368616
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65568663
40ZNF274_21170338_ChIP-Seq_K562_Hela1.65447620
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64952964
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58005803
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.57591025
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57026509
45TP53_16413492_ChIP-PET_HCT116_Human1.48499756
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.48202562
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46362319
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45432877
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45337978
50AR_25329375_ChIP-Seq_VCAP_Human1.42663125
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.42524492
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41521954
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41434715
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40814929
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39196801
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36572176
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36314673
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32083764
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.28246937
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.26986022
61TP53_18474530_ChIP-ChIP_U2OS_Human1.23580049
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23237262
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23224558
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22765258
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22728849
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22208091
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21348294
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.20288129
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20138666
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17544460
71CTCF_27219007_Chip-Seq_Bcells_Human1.15564599
72JUN_21703547_ChIP-Seq_K562_Human1.15351963
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.13371626
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.12754068
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12600889
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11629952
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11609748
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.09583141
79BCAT_22108803_ChIP-Seq_LS180_Human1.07300239
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06712379
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05419785
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04765824
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.04419666
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.03494341
85RNF2_27304074_Chip-Seq_NSC_Mouse1.02660486
86RUNX2_22187159_ChIP-Seq_PCA_Human1.01153722
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00756085
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00226195
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.99346768
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99179098
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97727590
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97135839
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97135839
94AR_19668381_ChIP-Seq_PC3_Human0.96997412
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96648187
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96629308
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96629233
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96516388
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95904924
100* STAT3_23295773_ChIP-Seq_U87_Human0.94878098
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94827914
102TCF4_23295773_ChIP-Seq_U87_Human0.94566798
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.94422407
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92462702
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91394415
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90880557
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.89908760
108IGF1R_20145208_ChIP-Seq_DFB_Human0.89578998
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89439695
110CBP_20019798_ChIP-Seq_JUKART_Human0.89439695
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89296206
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88643652
113KDM2B_26808549_Chip-Seq_K562_Human0.87262484
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87196209
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.86142629
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86072521
117AHR_22903824_ChIP-Seq_MCF-7_Human0.86045273
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86004361
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82690635
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82646049
121DPY_21335234_ChIP-Seq_ESCs_Mouse0.82607228
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82295520
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.79534525
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78442301
125SOX2_18555785_Chip-Seq_ESCs_Mouse0.77925906
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76948708
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.76472751
128MYC_19915707_ChIP-ChIP_AK7_Human0.76436769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.54110945
2MP0003880_abnormal_central_pattern6.20069411
3MP0003635_abnormal_synaptic_transmissio4.05260552
4MP0002063_abnormal_learning/memory/cond3.60657113
5MP0009745_abnormal_behavioral_response3.52571782
6MP0004270_analgesia3.35313350
7MP0003329_amyloid_beta_deposits2.84526408
8MP0002064_seizures2.83708014
9MP0002572_abnormal_emotion/affect_behav2.80967108
10MP0001968_abnormal_touch/_nociception2.77998534
11MP0002736_abnormal_nociception_after2.70443373
12MP0001440_abnormal_grooming_behavior2.53135019
13MP0001501_abnormal_sleep_pattern2.48889177
14MP0002822_catalepsy2.48106248
15MP0002837_dystrophic_cardiac_calcinosis2.37324842
16MP0002272_abnormal_nervous_system2.32073803
17MP0001486_abnormal_startle_reflex2.17137706
18MP0002735_abnormal_chemical_nociception2.08584494
19MP0000778_abnormal_nervous_system1.99216173
20MP0002184_abnormal_innervation1.92281586
21MP0002734_abnormal_mechanical_nocicepti1.83700974
22MP0001984_abnormal_olfaction1.80061866
23MP0006276_abnormal_autonomic_nervous1.77155241
24MP0009780_abnormal_chondrocyte_physiolo1.76820987
25MP0004858_abnormal_nervous_system1.75382228
26MP0009046_muscle_twitch1.72129594
27MP0002067_abnormal_sensory_capabilities1.70778295
28MP0001529_abnormal_vocalization1.68966441
29MP0002557_abnormal_social/conspecific_i1.61392663
30MP0001905_abnormal_dopamine_level1.60264469
31MP0008877_abnormal_DNA_methylation1.60237572
32MP0001188_hyperpigmentation1.51206349
33MP0002733_abnormal_thermal_nociception1.50931134
34MP0001970_abnormal_pain_threshold1.49513270
35MP0000604_amyloidosis1.45362626
36MP0002909_abnormal_adrenal_gland1.43511770
37MP0005394_taste/olfaction_phenotype1.42944404
38MP0005499_abnormal_olfactory_system1.42944404
39MP0004811_abnormal_neuron_physiology1.42117487
40MP0004885_abnormal_endolymph1.41178619
41MP0000955_abnormal_spinal_cord1.40500370
42MP0005386_behavior/neurological_phenoty1.38858323
43MP0004924_abnormal_behavior1.38858323
44MP0006292_abnormal_olfactory_placode1.37968949
45MP0005409_darkened_coat_color1.36092058
46MP0002882_abnormal_neuron_morphology1.35241637
47MP0004147_increased_porphyrin_level1.32788329
48MP0003879_abnormal_hair_cell1.31188657
49MP0005423_abnormal_somatic_nervous1.28708209
50MP0005187_abnormal_penis_morphology1.26562228
51MP0005646_abnormal_pituitary_gland1.26144100
52MP0010234_abnormal_vibrissa_follicle1.25666596
53MP0001177_atelectasis1.25589496
54MP0002066_abnormal_motor_capabilities/c1.25506530
55MP0003123_paternal_imprinting1.22039235
56MP0005645_abnormal_hypothalamus_physiol1.12738146
57MP0000678_abnormal_parathyroid_gland1.12083156
58MP0010386_abnormal_urinary_bladder1.08849440
59MP0000920_abnormal_myelination1.08815613
60MP0003938_abnormal_ear_development1.07972532
61MP0008569_lethality_at_weaning1.07309141
62MP0006036_abnormal_mitochondrial_physio1.06757185
63MP0004484_altered_response_of1.04765801
64MP0002152_abnormal_brain_morphology1.04296037
65MP0001963_abnormal_hearing_physiology1.01047666
66MP0003631_nervous_system_phenotype1.00654089
67MP0005551_abnormal_eye_electrophysiolog0.98744776
68MP0000751_myopathy0.98390171
69MP0001502_abnormal_circadian_rhythm0.97876005
70MP0002876_abnormal_thyroid_physiology0.97574539
71MP0001485_abnormal_pinna_reflex0.96921598
72MP0003632_abnormal_nervous_system0.96146990
73MP0005535_abnormal_body_temperature0.95150840
74MP0003633_abnormal_nervous_system0.94737816
75MP0008872_abnormal_physiological_respon0.93206064
76MP0009379_abnormal_foot_pigmentation0.91788866
77MP0002638_abnormal_pupillary_reflex0.91205508
78MP0003075_altered_response_to0.90853191
79MP0002234_abnormal_pharynx_morphology0.90641261
80MP0001664_abnormal_digestion0.90188912
81MP0003787_abnormal_imprinting0.89575038
82MP0004085_abnormal_heartbeat0.86543352
83MP0003137_abnormal_impulse_conducting0.86235947
84MP0000026_abnormal_inner_ear0.85369333
85MP0002069_abnormal_eating/drinking_beha0.84816482
86MP0002752_abnormal_somatic_nervous0.84733473
87MP0008789_abnormal_olfactory_epithelium0.81981270
88MP0000013_abnormal_adipose_tissue0.81341929
89MP0002229_neurodegeneration0.78102646
90MP0008874_decreased_physiological_sensi0.77072546
91MP0004145_abnormal_muscle_electrophysio0.75883622
92MP0004510_myositis0.75498299
93MP0004742_abnormal_vestibular_system0.75145310
94MP0004233_abnormal_muscle_weight0.74965402
95MP0003122_maternal_imprinting0.74440995
96MP0000647_abnormal_sebaceous_gland0.74298040
97MP0003638_abnormal_response/metabolism_0.72907560
98MP0003634_abnormal_glial_cell0.71789847
99MP0002090_abnormal_vision0.71745021
100MP0008875_abnormal_xenobiotic_pharmacok0.70711491
101MP0000631_abnormal_neuroendocrine_gland0.70481662
102MP0001986_abnormal_taste_sensitivity0.70309568
103MP0004215_abnormal_myocardial_fiber0.64813846
104MP0001346_abnormal_lacrimal_gland0.63966674
105MP0002102_abnormal_ear_morphology0.63399126
106MP0004043_abnormal_pH_regulation0.62667409
107MP0005167_abnormal_blood-brain_barrier0.62371372
108MP0004130_abnormal_muscle_cell0.61593850
109MP0006072_abnormal_retinal_apoptosis0.61117576
110MP0001765_abnormal_ion_homeostasis0.60612547
111MP0005595_abnormal_vascular_smooth0.60390296
112MP0002972_abnormal_cardiac_muscle0.59019606
113MP0003861_abnormal_nervous_system0.57735719
114MP0005165_increased_susceptibility_to0.56698854
115MP0004142_abnormal_muscle_tone0.56043209
116MP0003183_abnormal_peptide_metabolism0.55754055
117MP0004036_abnormal_muscle_relaxation0.54684387
118MP0003690_abnormal_glial_cell0.52955292
119MP0000639_abnormal_adrenal_gland0.52560480
120MP0005623_abnormal_meninges_morphology0.51037821
121MP0005379_endocrine/exocrine_gland_phen0.50596015
122MP0000534_abnormal_ureter_morphology0.50440171
123MP0005620_abnormal_muscle_contractility0.50115079
124MP0005410_abnormal_fertilization0.50028982
125MP0003956_abnormal_body_size0.49858720
126MP0003121_genomic_imprinting0.49518659
127MP0010769_abnormal_survival0.45605612

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.89018416
2Visual hallucinations (HP:0002367)6.56898838
3Cerebral inclusion bodies (HP:0100314)5.95845170
4Myokymia (HP:0002411)5.56846509
5Hyperventilation (HP:0002883)5.11561913
6Focal seizures (HP:0007359)4.84632664
7Absence seizures (HP:0002121)4.09159905
8Atonic seizures (HP:0010819)4.07058792
9Neurofibrillary tangles (HP:0002185)4.04240712
10Epileptic encephalopathy (HP:0200134)4.03039371
11Delusions (HP:0000746)3.95796137
12Neuronal loss in central nervous system (HP:0002529)3.92226423
13Sensorimotor neuropathy (HP:0007141)3.88159566
14Dialeptic seizures (HP:0011146)3.80504229
15Ankle clonus (HP:0011448)3.79330075
16Slow saccadic eye movements (HP:0000514)3.76741939
17Impaired vibratory sensation (HP:0002495)3.67996775
18Amblyopia (HP:0000646)3.62112163
19Papilledema (HP:0001085)3.47647105
20Spastic gait (HP:0002064)3.35083211
21Generalized tonic-clonic seizures (HP:0002069)3.34180794
22Postural instability (HP:0002172)3.30002798
23Broad-based gait (HP:0002136)3.24674661
24Supranuclear gaze palsy (HP:0000605)3.23194833
25Mutism (HP:0002300)3.18262952
26Anxiety (HP:0000739)3.16857741
27Febrile seizures (HP:0002373)3.10902191
28Abnormality of saccadic eye movements (HP:0000570)3.05400004
29Drooling (HP:0002307)3.02322916
30Excessive salivation (HP:0003781)3.02322916
31Bundle branch block (HP:0011710)3.00993810
32Epileptiform EEG discharges (HP:0011182)2.99331407
33Abnormality of binocular vision (HP:0011514)2.93162557
34Diplopia (HP:0000651)2.93162557
35Dysautonomia (HP:0002459)2.89917927
36Megalencephaly (HP:0001355)2.86481408
37Abnormality of the corticospinal tract (HP:0002492)2.82625479
38Tetraplegia (HP:0002445)2.82493572
39Cerebral hypomyelination (HP:0006808)2.81306074
40Urinary urgency (HP:0000012)2.81217466
41Ventricular fibrillation (HP:0001663)2.79731506
42Oligodactyly (hands) (HP:0001180)2.76275606
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.75292082
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.75292082
45Annular pancreas (HP:0001734)2.73710743
46Acute necrotizing encephalopathy (HP:0006965)2.70894587
47EEG with generalized epileptiform discharges (HP:0011198)2.70718572
48Poor eye contact (HP:0000817)2.69295714
49Arterial tortuosity (HP:0005116)2.67219876
50Abnormality of the lower motor neuron (HP:0002366)2.65231762
51Limb dystonia (HP:0002451)2.63486965
52Truncal ataxia (HP:0002078)2.63294083
53Intention tremor (HP:0002080)2.63008062
54Sudden death (HP:0001699)2.58482875
55Abnormal mitochondria in muscle tissue (HP:0008316)2.57697482
56Hemiparesis (HP:0001269)2.56519734
57Syncope (HP:0001279)2.53819691
58Depression (HP:0000716)2.52214467
59Progressive macrocephaly (HP:0004481)2.48583023
60Lower limb muscle weakness (HP:0007340)2.47985340
61Hypsarrhythmia (HP:0002521)2.47915186
62Calcaneovalgus deformity (HP:0001848)2.44675538
63Global brain atrophy (HP:0002283)2.39255605
64Limb ataxia (HP:0002070)2.36786859
65Psychosis (HP:0000709)2.36471634
66Inability to walk (HP:0002540)2.33105818
67Polyphagia (HP:0002591)2.32712537
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.32138900
69Progressive cerebellar ataxia (HP:0002073)2.29763613
70Akinesia (HP:0002304)2.29622826
71Deformed tarsal bones (HP:0008119)2.29534574
72Abnormal social behavior (HP:0012433)2.28891170
73Impaired social interactions (HP:0000735)2.28891170
74Progressive inability to walk (HP:0002505)2.27886273
75Sleep apnea (HP:0010535)2.27832985
76Vascular tortuosity (HP:0004948)2.27720675
77Heart block (HP:0012722)2.27385001
78Impaired vibration sensation in the lower limbs (HP:0002166)2.27358695
79Obstructive sleep apnea (HP:0002870)2.26842452
80Acute encephalopathy (HP:0006846)2.25641701
81Absent speech (HP:0001344)2.25227895
82Action tremor (HP:0002345)2.24439831
83Hemiplegia (HP:0002301)2.20556554
84Dysmetria (HP:0001310)2.20291523
85Rapidly progressive (HP:0003678)2.18380543
86Gait ataxia (HP:0002066)2.16692401
87Mitochondrial inheritance (HP:0001427)2.16251072
88Rigidity (HP:0002063)2.12837123
89Dysdiadochokinesis (HP:0002075)2.12159626
90Brittle hair (HP:0002299)2.11892356
91Split foot (HP:0001839)2.10799011
92Abnormality of salivation (HP:0100755)2.09038044
93Clonus (HP:0002169)2.05260638
94Thickened helices (HP:0000391)2.02890181
95Abnormal respiratory motile cilium physiology (HP:0012261)2.01212397
96Incomplete penetrance (HP:0003829)2.01212244
97Abnormal atrioventricular conduction (HP:0005150)2.00048844
98Abnormal EKG (HP:0003115)1.99848451
99Choreoathetosis (HP:0001266)1.99821472
100Testicular atrophy (HP:0000029)1.99686306
101Double outlet right ventricle (HP:0001719)1.99320558
102Congenital malformation of the right heart (HP:0011723)1.99320558
103Hydroureter (HP:0000072)1.98642372
104Focal dystonia (HP:0004373)1.98477680
105Rhinitis (HP:0012384)1.97807343
106Stereotypic behavior (HP:0000733)1.97211083
107Torticollis (HP:0000473)1.96718708
108Absent/shortened dynein arms (HP:0200106)1.96082841
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.96082841
110Gait imbalance (HP:0002141)1.95214023
111Abnormal ciliary motility (HP:0012262)1.95184472
112Atrioventricular block (HP:0001678)1.95126511
113Primary atrial arrhythmia (HP:0001692)1.94661298
114Generalized myoclonic seizures (HP:0002123)1.94032833
115Abnormal respiratory epithelium morphology (HP:0012253)1.93256538
116Abnormal respiratory motile cilium morphology (HP:0005938)1.93256538
117Mixed hearing impairment (HP:0000410)1.92904692
118Atrial fibrillation (HP:0005110)1.91264384
119Prolonged QT interval (HP:0001657)1.91068336
120Abnormality of the antihelix (HP:0009738)1.90182165
121Palpebral edema (HP:0100540)1.90166823
122Fair hair (HP:0002286)1.89876934
123Morphological abnormality of the pyramidal tract (HP:0002062)1.89862187
124Termporal pattern (HP:0011008)1.89587351
125Insidious onset (HP:0003587)1.89587351
126Athetosis (HP:0002305)1.88898824
127Gaze-evoked nystagmus (HP:0000640)1.88717853
128Bradykinesia (HP:0002067)1.88248510
129Supraventricular tachycardia (HP:0004755)1.87966956
130Humeroradial synostosis (HP:0003041)1.86052392
131Synostosis involving the elbow (HP:0003938)1.86052392
132Unsteady gait (HP:0002317)1.84745435
133Slow progression (HP:0003677)1.84268775
134Impaired smooth pursuit (HP:0007772)1.83997765
135Retinal dysplasia (HP:0007973)1.81468586
136Craniofacial dystonia (HP:0012179)1.81134440
137Heterochromia iridis (HP:0001100)1.80784270
138Apathy (HP:0000741)1.80434926
139Supraventricular arrhythmia (HP:0005115)1.79910281
140Status epilepticus (HP:0002133)1.78460885
141Medial flaring of the eyebrow (HP:0010747)1.76847680
142Abnormal autonomic nervous system physiology (HP:0012332)1.76533554
143Bronchomalacia (HP:0002780)1.75786432
144Oligodactyly (HP:0012165)1.75293419
145Abnormal gallbladder physiology (HP:0012438)1.75071382
146Cholecystitis (HP:0001082)1.75071382
147Protruding tongue (HP:0010808)1.74596226
148Anosmia (HP:0000458)1.73028746
149Amyotrophic lateral sclerosis (HP:0007354)1.71812151
150Deep palmar crease (HP:0006191)1.71782537
151Congenital primary aphakia (HP:0007707)1.71471619
152Increased CSF lactate (HP:0002490)1.71251769
153Orthostatic hypotension (HP:0001278)1.71137678
154Decreased circulating renin level (HP:0003351)1.70744059
155Abnormal eating behavior (HP:0100738)1.70434259
156Urinary bladder sphincter dysfunction (HP:0002839)1.69594507
157Lower limb asymmetry (HP:0100559)1.69191355

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.19558065
2NTRK34.00686692
3RIPK43.87801680
4MAP3K123.02573987
5PLK22.93378633
6MAP3K92.78874065
7PTK2B2.78179498
8FGR2.69571559
9MINK12.68647758
10GRK62.43300012
11GRK52.36742873
12MAP3K42.25827963
13PNCK2.25143003
14NME12.03051434
15ARAF2.01631701
16MAP2K72.01480577
17BMPR22.01480506
18KSR21.89627925
19KSR11.80811629
20CASK1.77293157
21MAP3K131.73897493
22DAPK11.73047933
23MAP2K41.66551559
24DAPK21.57159048
25PRPF4B1.56626277
26PINK11.55286914
27LMTK21.46820079
28SIK21.45177568
29PRKD31.44190642
30CAMKK21.32254813
31CAMK2A1.30549572
32MARK11.30237818
33CDK51.27976823
34FES1.25964231
35PRKCG1.20998348
36NTRK21.19142462
37CAMK2B1.14631683
38DYRK1A1.12645232
39TESK11.10934188
40RAF11.10393458
41CDK191.00047137
42FER0.99694546
43DAPK30.95809126
44TNIK0.94934667
45NTRK10.92680818
46PRKCH0.90228623
47ALK0.88849551
48MAP3K20.86601115
49PAK60.84927088
50STK380.81415019
51MAPK120.79444956
52PDK30.79143089
53PDK40.79143089
54PKN10.77102470
55RIPK10.76016631
56CAMKK10.75089145
57DMPK0.74888116
58NEK60.72488216
59CAMK2D0.70047576
60MAPK130.69730302
61TAOK20.69528219
62CDK140.69012281
63BRSK10.68408792
64PHKG20.67689926
65PHKG10.67689926
66STK110.67518458
67OXSR10.66058228
68PLK30.65802520
69LIMK10.65180555
70BCR0.64348202
71CDK180.63523619
72SGK10.62809208
73MST40.61616824
74CDK150.58640352
75ROCK20.58250441
76SGK4940.55198188
77SGK2230.55198188
78MOS0.54188336
79PRKCE0.53493825
80BRAF0.53207770
81MARK20.51772242
82LATS20.50898517
83CAMK40.50871226
84CDK11A0.49228305
85SGK30.47811538
86PAK30.46775342
87PRKCZ0.46516949
88PRKD20.45813565
89MAP3K10.44982718
90MAP3K60.42221653
91RET0.42204529
92MAP2K10.40191222
93ADRBK10.39740828
94PDPK10.38987567
95CAMK2G0.38807242
96PRKG10.36917872
97PRKCQ0.36829469
98CSNK1G20.35648596
99TYRO30.35513093
100TRIM280.34635690
101ROCK10.34105585
102SIK30.33672762
103PDK20.33626505
104FYN0.33252450
105CAMK10.32806912
106PAK10.32723073
107SGK20.30879082
108MAP3K70.30287479
109PRKACA0.30059585
110UHMK10.29095430
111MYLK0.27922874
112MAPK100.27189991
113PRKCA0.26316994
114BMX0.26285990
115GRK70.26284640
116CCNB10.25398298
117PDK10.25323237
118CSNK1E0.25132100
119MAP3K110.24112718
120RPS6KA30.23561667
121IRAK20.23241372
122SYK0.23063088
123ABL20.21703609
124PRKCB0.20747754

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.29147918
2Long-term potentiation_Homo sapiens_hsa047203.46953450
3Amphetamine addiction_Homo sapiens_hsa050312.97501371
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82386736
5Circadian entrainment_Homo sapiens_hsa047132.71575274
6Glutamatergic synapse_Homo sapiens_hsa047242.66279808
7Olfactory transduction_Homo sapiens_hsa047402.63380398
8Synaptic vesicle cycle_Homo sapiens_hsa047212.53642148
9Morphine addiction_Homo sapiens_hsa050322.41325775
10GABAergic synapse_Homo sapiens_hsa047272.34361270
11Salivary secretion_Homo sapiens_hsa049702.33520481
12Dopaminergic synapse_Homo sapiens_hsa047282.26643681
13Renin secretion_Homo sapiens_hsa049242.26120413
14Collecting duct acid secretion_Homo sapiens_hsa049662.22895832
15Oxidative phosphorylation_Homo sapiens_hsa001902.04473422
16Alzheimers disease_Homo sapiens_hsa050101.97165435
17Taste transduction_Homo sapiens_hsa047421.96789142
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92627010
19Gastric acid secretion_Homo sapiens_hsa049711.89785644
20Calcium signaling pathway_Homo sapiens_hsa040201.88566881
21Vitamin B6 metabolism_Homo sapiens_hsa007501.88168378
22Long-term depression_Homo sapiens_hsa047301.74724839
23Serotonergic synapse_Homo sapiens_hsa047261.74192138
24Phototransduction_Homo sapiens_hsa047441.70557884
25Oxytocin signaling pathway_Homo sapiens_hsa049211.67086447
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60895264
27Parkinsons disease_Homo sapiens_hsa050121.53503692
28Cholinergic synapse_Homo sapiens_hsa047251.51266365
29Insulin secretion_Homo sapiens_hsa049111.48130372
30Cardiac muscle contraction_Homo sapiens_hsa042601.45924816
31GnRH signaling pathway_Homo sapiens_hsa049121.40118717
32Cocaine addiction_Homo sapiens_hsa050301.38985784
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36927214
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36925511
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35316062
36Gap junction_Homo sapiens_hsa045401.33579943
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.29819446
38Vibrio cholerae infection_Homo sapiens_hsa051101.28671297
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26960027
40Melanogenesis_Homo sapiens_hsa049161.25944649
41cAMP signaling pathway_Homo sapiens_hsa040241.23481230
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23473948
43Axon guidance_Homo sapiens_hsa043601.20831141
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18405211
45Huntingtons disease_Homo sapiens_hsa050161.10526558
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09620342
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08516932
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07680027
49Glioma_Homo sapiens_hsa052141.07338559
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04865910
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00103072
52Oocyte meiosis_Homo sapiens_hsa041140.99843248
53Estrogen signaling pathway_Homo sapiens_hsa049150.97778926
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88691741
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86300992
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.85486142
57Arginine and proline metabolism_Homo sapiens_hsa003300.82339557
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79215795
59Glucagon signaling pathway_Homo sapiens_hsa049220.78438985
60VEGF signaling pathway_Homo sapiens_hsa043700.77647575
61Pancreatic secretion_Homo sapiens_hsa049720.76243072
62African trypanosomiasis_Homo sapiens_hsa051430.75341324
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73882890
64Circadian rhythm_Homo sapiens_hsa047100.70326803
65Arginine biosynthesis_Homo sapiens_hsa002200.67673202
66Choline metabolism in cancer_Homo sapiens_hsa052310.66671444
67Phenylalanine metabolism_Homo sapiens_hsa003600.65995981
68ErbB signaling pathway_Homo sapiens_hsa040120.60868423
69Thyroid hormone synthesis_Homo sapiens_hsa049180.56645568
70Butanoate metabolism_Homo sapiens_hsa006500.52494821
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51705984
72Prion diseases_Homo sapiens_hsa050200.49131910
73Rap1 signaling pathway_Homo sapiens_hsa040150.47475610
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.46707435
75Histidine metabolism_Homo sapiens_hsa003400.46621089
76Type II diabetes mellitus_Homo sapiens_hsa049300.46290844
77Ras signaling pathway_Homo sapiens_hsa040140.43960434
78beta-Alanine metabolism_Homo sapiens_hsa004100.43590115
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40491127
80Wnt signaling pathway_Homo sapiens_hsa043100.39752419
81Alcoholism_Homo sapiens_hsa050340.38825271
82MAPK signaling pathway_Homo sapiens_hsa040100.37618759
83Dilated cardiomyopathy_Homo sapiens_hsa054140.37010338
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35116503
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34749911
86Mineral absorption_Homo sapiens_hsa049780.33831544
87Sulfur metabolism_Homo sapiens_hsa009200.32428103
88Pyruvate metabolism_Homo sapiens_hsa006200.32213893
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31882384
90Bile secretion_Homo sapiens_hsa049760.31841308
91Tight junction_Homo sapiens_hsa045300.30881991
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28668811
93Rheumatoid arthritis_Homo sapiens_hsa053230.28300569
94Endocytosis_Homo sapiens_hsa041440.28230126
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.27780923
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27543274
97Carbon metabolism_Homo sapiens_hsa012000.24468802
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24218440
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23942310
100Regulation of autophagy_Homo sapiens_hsa041400.23445640
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22292348
102Propanoate metabolism_Homo sapiens_hsa006400.22112257
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21699601
104Fatty acid elongation_Homo sapiens_hsa000620.21296482
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20673373
106Inositol phosphate metabolism_Homo sapiens_hsa005620.20572535
107Dorso-ventral axis formation_Homo sapiens_hsa043200.20067847
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.19696284
109Nitrogen metabolism_Homo sapiens_hsa009100.19650244
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18842668
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17890979
112Type I diabetes mellitus_Homo sapiens_hsa049400.17707343
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12555291
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12495147
115Non-small cell lung cancer_Homo sapiens_hsa052230.11722727
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.09809455
117Glycerolipid metabolism_Homo sapiens_hsa005610.08579429
118Fatty acid biosynthesis_Homo sapiens_hsa000610.08318409
119Phagosome_Homo sapiens_hsa041450.08303209

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