CRYZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.34728839
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.34728839
3L-phenylalanine metabolic process (GO:0006558)7.15768593
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.15768593
5glyoxylate metabolic process (GO:0046487)6.83647456
6aromatic amino acid family catabolic process (GO:0009074)6.75656235
7lysine metabolic process (GO:0006553)6.61488112
8lysine catabolic process (GO:0006554)6.61488112
9cysteine metabolic process (GO:0006534)6.34527598
10urate metabolic process (GO:0046415)6.19391832
11indole-containing compound catabolic process (GO:0042436)6.18154239
12indolalkylamine catabolic process (GO:0046218)6.18154239
13tryptophan catabolic process (GO:0006569)6.18154239
14drug transmembrane transport (GO:0006855)6.02544110
15tryptophan metabolic process (GO:0006568)5.86268985
16kynurenine metabolic process (GO:0070189)5.74352425
17serine family amino acid catabolic process (GO:0009071)5.58839913
18homocysteine metabolic process (GO:0050667)5.42100546
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.30897907
20bile acid biosynthetic process (GO:0006699)5.28784645
21drug catabolic process (GO:0042737)5.24452886
22sulfur amino acid catabolic process (GO:0000098)5.22486704
23amino-acid betaine metabolic process (GO:0006577)5.17925993
24drug transport (GO:0015893)5.04050630
25aromatic amino acid family metabolic process (GO:0009072)4.98136316
26serine family amino acid metabolic process (GO:0009069)4.97334275
27cellular ketone body metabolic process (GO:0046950)4.86333961
28short-chain fatty acid metabolic process (GO:0046459)4.83839820
29alpha-amino acid catabolic process (GO:1901606)4.83835695
30alpha-linolenic acid metabolic process (GO:0036109)4.82609063
31exogenous drug catabolic process (GO:0042738)4.80052957
32aspartate family amino acid catabolic process (GO:0009068)4.79079611
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.77210011
34serine family amino acid biosynthetic process (GO:0009070)4.63132665
35urea metabolic process (GO:0019627)4.62173573
36urea cycle (GO:0000050)4.62173573
37cellular modified amino acid catabolic process (GO:0042219)4.61782268
38cellular amino acid catabolic process (GO:0009063)4.61402439
39glutamate metabolic process (GO:0006536)4.51242028
40glycine metabolic process (GO:0006544)4.42861881
41bile acid metabolic process (GO:0008206)4.41226145
42tyrosine metabolic process (GO:0006570)4.40138880
43indolalkylamine metabolic process (GO:0006586)4.35739336
442-oxoglutarate metabolic process (GO:0006103)4.30685666
45nitrogen cycle metabolic process (GO:0071941)4.30635681
46acetyl-CoA metabolic process (GO:0006084)4.29203302
47response to mercury ion (GO:0046689)4.23185101
48negative regulation of fibrinolysis (GO:0051918)4.21665403
49ketone body metabolic process (GO:1902224)4.21603796
50cellular biogenic amine catabolic process (GO:0042402)4.20351436
51amine catabolic process (GO:0009310)4.20351436
52fatty acid beta-oxidation (GO:0006635)4.19402351
53benzene-containing compound metabolic process (GO:0042537)4.16192568
54aldehyde catabolic process (GO:0046185)4.14936960
55peptidyl-glutamic acid carboxylation (GO:0017187)4.13124900
56protein carboxylation (GO:0018214)4.13124900
57phosphate ion transport (GO:0006817)4.11841127
58organic acid catabolic process (GO:0016054)4.10944611
59carboxylic acid catabolic process (GO:0046395)4.10944611
60ethanol oxidation (GO:0006069)4.10366986
61epoxygenase P450 pathway (GO:0019373)4.10322449
62fatty acid oxidation (GO:0019395)4.08709290
63valine metabolic process (GO:0006573)4.08497052
64carnitine metabolic process (GO:0009437)4.08482781
65branched-chain amino acid metabolic process (GO:0009081)4.08169015
66high-density lipoprotein particle remodeling (GO:0034375)4.07473914
67cellular glucuronidation (GO:0052695)4.02630996
68branched-chain amino acid catabolic process (GO:0009083)4.01202062
69lipid oxidation (GO:0034440)4.00707391
70daunorubicin metabolic process (GO:0044597)4.00473286
71polyketide metabolic process (GO:0030638)4.00473286
72doxorubicin metabolic process (GO:0044598)4.00473286
73regulation of fibrinolysis (GO:0051917)3.95683415
74negative regulation of sterol transport (GO:0032372)3.94575008
75negative regulation of cholesterol transport (GO:0032375)3.94575008
76coenzyme catabolic process (GO:0009109)3.93966135
77dicarboxylic acid biosynthetic process (GO:0043650)3.91746502
78organic cation transport (GO:0015695)3.91701670
79phosphate ion transmembrane transport (GO:0035435)3.90230229
80complement activation, alternative pathway (GO:0006957)3.88153293
81regulation of protein activation cascade (GO:2000257)3.86337593
82tricarboxylic acid metabolic process (GO:0072350)3.86308933
83monocarboxylic acid catabolic process (GO:0072329)3.85700534
84S-adenosylmethionine metabolic process (GO:0046500)3.83757861
85fatty acid catabolic process (GO:0009062)3.82456689
86intestinal cholesterol absorption (GO:0030299)3.80288495
87glucuronate metabolic process (GO:0019585)3.76092810
88uronic acid metabolic process (GO:0006063)3.76092810
89water-soluble vitamin biosynthetic process (GO:0042364)3.75633436
90triglyceride homeostasis (GO:0070328)3.74156609
91acylglycerol homeostasis (GO:0055090)3.74156609
92drug metabolic process (GO:0017144)3.73154500
93blood coagulation, intrinsic pathway (GO:0007597)3.67150985
94regulation of triglyceride catabolic process (GO:0010896)3.66892999
95regulation of complement activation (GO:0030449)3.60490326
96quaternary ammonium group transport (GO:0015697)3.59999939
97phenylpropanoid metabolic process (GO:0009698)3.59005582
98arginine metabolic process (GO:0006525)3.57642911
99flavonoid metabolic process (GO:0009812)3.57333813
100regulation of cholesterol homeostasis (GO:2000188)3.57327648
101negative regulation of protein activation cascade (GO:2000258)3.56908448
102fibrinolysis (GO:0042730)3.56726111
103fructose metabolic process (GO:0006000)3.56573417
104reverse cholesterol transport (GO:0043691)3.55160355
105regulation of cholesterol esterification (GO:0010872)3.54349422
106omega-hydroxylase P450 pathway (GO:0097267)3.53329953
107aminoglycoside antibiotic metabolic process (GO:0030647)3.52114972
108bile acid and bile salt transport (GO:0015721)3.51262395
109dicarboxylic acid metabolic process (GO:0043648)3.50303490
110small molecule catabolic process (GO:0044282)3.50269513
111plasma lipoprotein particle remodeling (GO:0034369)3.49788242
112macromolecular complex remodeling (GO:0034367)3.49788242
113L-methionine salvage (GO:0071267)3.27123319
114L-methionine biosynthetic process (GO:0071265)3.27123319
115amino acid salvage (GO:0043102)3.27123319
116very-low-density lipoprotein particle assembly (GO:0034379)3.22938928
117oxidative demethylation (GO:0070989)3.19426095
118COPII vesicle coating (GO:0048208)3.10215152
119pteridine-containing compound biosynthetic process (GO:0042559)3.08042756
120regulation of hexokinase activity (GO:1903299)3.06866792
121regulation of glucokinase activity (GO:0033131)3.06866792
122negative regulation of complement activation (GO:0045916)3.04455438
123heme transport (GO:0015886)3.00462011
124cholesterol efflux (GO:0033344)3.00106576
125respiratory chain complex IV assembly (GO:0008535)2.98873078
126cellular aldehyde metabolic process (GO:0006081)2.97197943
127protein-lipid complex remodeling (GO:0034368)2.95655701
128tetrahydrofolate metabolic process (GO:0046653)2.95273170
129regulation of plasminogen activation (GO:0010755)2.90880952
130response to nitrosative stress (GO:0051409)2.88708643
131vitamin biosynthetic process (GO:0009110)2.87647270
132lactate metabolic process (GO:0006089)2.82302053
133negative regulation of coagulation (GO:0050819)2.78842415
134ethanol metabolic process (GO:0006067)2.76310273
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.72477539
136negative regulation of hemostasis (GO:1900047)2.69525646
137negative regulation of blood coagulation (GO:0030195)2.69525646
138negative regulation of wound healing (GO:0061045)2.65527606
139L-ascorbic acid metabolic process (GO:0019852)2.65480446
140negative regulation of lipase activity (GO:0060192)2.64469013
141mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.62906116
142retinal metabolic process (GO:0042574)2.62786524
143tricarboxylic acid cycle (GO:0006099)2.61899676
144* xenobiotic catabolic process (GO:0042178)2.59313023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.22377078
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.07628710
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.22028943
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.12826652
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.46002339
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.66313235
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.56934649
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89010893
9* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86870287
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.72768245
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.80991547
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.69248004
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.66921978
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.37910910
15ELK1_19687146_ChIP-ChIP_HELA_Human2.25660481
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.24640716
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13170447
18CLOCK_20551151_ChIP-Seq_293T_Human2.05301541
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02291605
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5179881
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.82977823
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.81703972
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81506887
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80188741
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77744438
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70804752
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65139923
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65107803
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63959599
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62867838
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61542424
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.56732263
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.53271722
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51954141
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.51574612
36FUS_26573619_Chip-Seq_HEK293_Human1.49013185
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.47455807
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47002065
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44418537
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41530142
41VDR_23849224_ChIP-Seq_CD4+_Human1.41372104
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38589001
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.36539013
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35825532
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35056851
46* FOXP3_21729870_ChIP-Seq_TREG_Human1.31304029
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30942065
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.30573161
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.30021500
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28849667
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28795634
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28467085
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27163330
54DCP1A_22483619_ChIP-Seq_HELA_Human1.26226513
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.24265222
56EWS_26573619_Chip-Seq_HEK293_Human1.22821319
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20875139
58VDR_22108803_ChIP-Seq_LS180_Human1.20588479
59SOX17_20123909_ChIP-Seq_XEN_Mouse1.18876115
60ZNF274_21170338_ChIP-Seq_K562_Hela1.17860872
61AR_21909140_ChIP-Seq_LNCAP_Human1.17353207
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14188280
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13473565
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12989846
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12641752
66GATA4_25053715_ChIP-Seq_YYC3_Human1.11503080
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09659215
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09657210
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09617261
70CDX2_22108803_ChIP-Seq_LS180_Human1.08932327
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.08124310
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07943755
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.07480134
74* P300_19829295_ChIP-Seq_ESCs_Human1.06061255
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05914203
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05027714
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04564804
78NANOG_19829295_ChIP-Seq_ESCs_Human1.02463160
79SOX2_19829295_ChIP-Seq_ESCs_Human1.02463160
80E2F7_22180533_ChIP-Seq_HELA_Human1.01977641
81HTT_18923047_ChIP-ChIP_STHdh_Human1.01334385
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00203181
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00003016
84* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99947132
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97315494
86* PHF8_20622853_ChIP-Seq_HELA_Human0.97265629
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97055416
88* TAF15_26573619_Chip-Seq_HEK293_Human0.96767269
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.96666368
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96666368
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.96363056
92* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96313927
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95570041
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95412596
95* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94239703
96MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93802017
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93486577
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92302057
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.92002408
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91589331
101OCT4_18555785_Chip-Seq_ESCs_Mouse0.91393070
102* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91143482
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91139844
104ESR2_21235772_ChIP-Seq_MCF-7_Human0.90338301
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89095017
106GATA1_22025678_ChIP-Seq_K562_Human0.89004221
107* SOX2_18555785_Chip-Seq_ESCs_Mouse0.88866138
108MYC_18940864_ChIP-ChIP_HL60_Human0.88866002
109IRF1_19129219_ChIP-ChIP_H3396_Human0.88669072
110SOX2_20726797_ChIP-Seq_SW620_Human0.88569447
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.81196109
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81185107
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79535890
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78772931
115AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77471225
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77167810
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70813360
118* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70592526
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70036016
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68165542
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.66978928
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65600538
123LXR_22292898_ChIP-Seq_THP-1_Human0.64895029
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64885166
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.64383096
126TRIM28_21343339_ChIP-Seq_HEK293_Human0.63917926
127AR_20517297_ChIP-Seq_VCAP_Human0.63861487
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.63199795
129GATA6_25053715_ChIP-Seq_YYC3_Human0.62968813
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.61975661
131* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61920269
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.61668992
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61565192
134ZNF263_19887448_ChIP-Seq_K562_Human0.60321720
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.58386750
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57838898
137CEBPB_22108803_ChIP-Seq_LS180_Human0.57635733
138CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.57356975
139IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.56807886
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.56581302
141TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.54784163
142* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.54470847
143* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.54470847
144RARB_24833708_ChIP-Seq_LIVER_Mouse0.53643608
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.53588306
146* MYC_19915707_ChIP-ChIP_AK7_Human0.52635179
147EGR1_19032775_ChIP-ChIP_M12_Human0.52400328
148PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51815394
149RACK7_27058665_Chip-Seq_MCF-7_Human0.51430482
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.50543833
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.50434251
152OCT4_18692474_ChIP-Seq_MEFs_Mouse0.50082660
153CBP_21632823_ChIP-Seq_H3396_Human0.49740210
154TAF2_19829295_ChIP-Seq_ESCs_Human0.48474817
155ESET_19884257_ChIP-Seq_ESCs_Mouse0.48460146
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48092473
157NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.47600750
158SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47203608
159* NANOG_16518401_ChIP-PET_MESCs_Mouse0.46461360
160NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.46085943
161GATA3_24758297_ChIP-Seq_MCF-7_Human0.45982986
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.45191003
163EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.45046535
164FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45008986
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44933859
166CSB_26484114_Chip-Seq_FIBROBLAST_Human0.44513867
167NANOG_18692474_ChIP-Seq_MEFs_Mouse0.44313407
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43580195
169TET1_21451524_ChIP-Seq_MESCs_Mouse0.42990362
170SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.42627739
171P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.42293553
172* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42110950
173SOX2_22085726_ChIP-Seq_NPCs_Mouse0.41797054
174* STAT1_17558387_ChIP-Seq_HELA_Human0.41700595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.15946082
2MP0002139_abnormal_hepatobiliary_system7.82898504
3MP0005085_abnormal_gallbladder_physiolo5.52382684
4MP0005365_abnormal_bile_salt5.38152078
5MP0008875_abnormal_xenobiotic_pharmacok4.83505802
6MP0003806_abnormal_nucleotide_metabolis3.98832958
7MP0005332_abnormal_amino_acid3.91130448
8MP0003195_calcinosis3.74868904
9MP0003252_abnormal_bile_duct3.68773911
10MP0004019_abnormal_vitamin_homeostasis3.42001106
11MP0010329_abnormal_lipoprotein_level2.87035715
12MP0002138_abnormal_hepatobiliary_system2.68183663
13MP0004043_abnormal_pH_regulation2.52510808
14MP0009643_abnormal_urine_homeostasis2.36175767
15MP0009840_abnormal_foam_cell2.32473644
16MP0005083_abnormal_biliary_tract2.27841691
17MP0001666_abnormal_nutrient_absorption2.19449486
18MP0005379_endocrine/exocrine_gland_phen2.01427094
19MP0003941_abnormal_skin_development1.95041238
20MP0002118_abnormal_lipid_homeostasis1.87183485
21MP0005319_abnormal_enzyme/_coenzyme1.85759308
22MP0003191_abnormal_cellular_cholesterol1.84840876
23MP0000609_abnormal_liver_physiology1.79907531
24MP0005636_abnormal_mineral_homeostasis1.79405695
25MP0003186_abnormal_redox_activity1.77975132
26MP0002163_abnormal_gland_morphology1.77765172
27MP0005584_abnormal_enzyme/coenzyme_acti1.74327862
28MP0010234_abnormal_vibrissa_follicle1.69227568
29MP0001764_abnormal_homeostasis1.66870399
30MP0009780_abnormal_chondrocyte_physiolo1.63404103
31MP0001756_abnormal_urination1.62672762
32MP0010386_abnormal_urinary_bladder1.49966168
33MP0003950_abnormal_plasma_membrane1.43879098
34MP0005451_abnormal_body_composition1.40809656
35MP0002136_abnormal_kidney_physiology1.36108847
36MP0001765_abnormal_ion_homeostasis1.35938160
37MP0000372_irregular_coat_pigmentation1.30469141
38MP0003868_abnormal_feces_composition1.28990991
39MP0006036_abnormal_mitochondrial_physio1.28278459
40MP0002938_white_spotting1.28148052
41MP0002909_abnormal_adrenal_gland1.16019428
42MP0002090_abnormal_vision1.15223041
43MP0004272_abnormal_basement_membrane1.12704921
44MP0005670_abnormal_white_adipose1.11626252
45MP0008058_abnormal_DNA_repair1.10591337
46MP0005084_abnormal_gallbladder_morpholo1.10079452
47MP0002876_abnormal_thyroid_physiology1.07397879
48MP0000598_abnormal_liver_morphology1.07234293
49MP0004957_abnormal_blastocyst_morpholog1.05524896
50MP0003693_abnormal_embryo_hatching1.02776285
51MP0003283_abnormal_digestive_organ1.00868371
52MP0003011_delayed_dark_adaptation0.97380861
53MP0006072_abnormal_retinal_apoptosis0.94278825
54MP0010678_abnormal_skin_adnexa0.94277407
55MP0008877_abnormal_DNA_methylation0.92607781
56MP0003705_abnormal_hypodermis_morpholog0.90803407
57MP0009697_abnormal_copulation0.89606991
58MP0004215_abnormal_myocardial_fiber0.88913456
59MP0001661_extended_life_span0.87937467
60MP0009642_abnormal_blood_homeostasis0.87914126
61MP0009764_decreased_sensitivity_to0.85518109
62MP0005408_hypopigmentation0.83653978
63MP0002132_abnormal_respiratory_system0.82690193
64MP0006054_spinal_hemorrhage0.82430910
65MP0005535_abnormal_body_temperature0.82026225
66MP0005058_abnormal_lysosome_morphology0.81358759
67MP0006035_abnormal_mitochondrial_morpho0.80035855
68MP0005220_abnormal_exocrine_pancreas0.80020734
69MP0003890_abnormal_embryonic-extraembry0.77137432
70MP0005647_abnormal_sex_gland0.76803030
71MP0002078_abnormal_glucose_homeostasis0.76656606
72MP0003656_abnormal_erythrocyte_physiolo0.76390924
73MP0010094_abnormal_chromosome_stability0.75244656
74MP0000604_amyloidosis0.74783159
75MP0002928_abnormal_bile_duct0.74438376
76MP0005376_homeostasis/metabolism_phenot0.74340967
77MP0000566_synostosis0.73873092
78MP0003122_maternal_imprinting0.73643406
79MP0009053_abnormal_anal_canal0.72436080
80MP0002233_abnormal_nose_morphology0.72088782
81MP0008469_abnormal_protein_level0.71723174
82MP0002693_abnormal_pancreas_physiology0.70027548
83MP0009763_increased_sensitivity_to0.68794881
84MP0000538_abnormal_urinary_bladder0.68111739
85MP0003786_premature_aging0.67777151
86MP0002168_other_aberrant_phenotype0.67607172
87MP0005187_abnormal_penis_morphology0.67223463
88MP0005551_abnormal_eye_electrophysiolog0.67054420
89MP0002971_abnormal_brown_adipose0.66886634
90MP0000358_abnormal_cell_content/0.66625578
91MP0005666_abnormal_adipose_tissue0.65895130
92MP0005266_abnormal_metabolism0.65602925
93MP0005395_other_phenotype0.65092174
94MP0000230_abnormal_systemic_arterial0.63232870
95MP0003329_amyloid_beta_deposits0.62666647
96MP0001915_intracranial_hemorrhage0.62611658
97MP0003638_abnormal_response/metabolism_0.61402960
98MP0004133_heterotaxia0.60557546
99MP0008961_abnormal_basal_metabolism0.59833388
100MP0009765_abnormal_xenobiotic_induced0.59593835
101MP0001984_abnormal_olfaction0.59447532
102MP0005410_abnormal_fertilization0.59281003
103MP0005330_cardiomyopathy0.59002184
104MP0000647_abnormal_sebaceous_gland0.58563832
105MP0003111_abnormal_nucleus_morphology0.58301661
106MP0003878_abnormal_ear_physiology0.58135748
107MP0005377_hearing/vestibular/ear_phenot0.58135748
108MP0002135_abnormal_kidney_morphology0.57967019
109MP0008007_abnormal_cellular_replicative0.56528336
110MP0003943_abnormal_hepatobiliary_system0.55489821
111MP0003136_yellow_coat_color0.54735507
112MP0010352_gastrointestinal_tract_polyps0.54102642
113MP0005253_abnormal_eye_physiology0.53962058
114MP0008932_abnormal_embryonic_tissue0.52472191
115MP0003123_paternal_imprinting0.52416349
116MP0004130_abnormal_muscle_cell0.52368441
117MP0002254_reproductive_system_inflammat0.51031997
118MP0005334_abnormal_fat_pad0.49583940
119MP0001730_embryonic_growth_arrest0.49174385
120MP0000013_abnormal_adipose_tissue0.48743635
121MP0001697_abnormal_embryo_size0.48573994
122MP0001293_anophthalmia0.47461502
123MP0004264_abnormal_extraembryonic_tissu0.47424999
124MP0003953_abnormal_hormone_level0.46650284
125MP0001958_emphysema0.45250976
126MP0000003_abnormal_adipose_tissue0.44899799
127MP0001929_abnormal_gametogenesis0.44825406
128MP0010368_abnormal_lymphatic_system0.44576443
129MP0002796_impaired_skin_barrier0.43984588
130MP0002837_dystrophic_cardiac_calcinosis0.42955395
131MP0009672_abnormal_birth_weight0.42169325
132MP0003718_maternal_effect0.41723282
133MP0003690_abnormal_glial_cell0.41052692
134MP0004147_increased_porphyrin_level0.40900775
135MP0004885_abnormal_endolymph0.39558722
136MP0003959_abnormal_lean_body0.36728071
137MP0002896_abnormal_bone_mineralization0.34451040
138MP0009384_cardiac_valve_regurgitation0.30505093
139MP0008872_abnormal_physiological_respon0.30355725
140MP0004782_abnormal_surfactant_physiolog0.30127458
141MP0008873_increased_physiological_sensi0.30069987
142MP0008874_decreased_physiological_sensi0.29310700
143MP0005448_abnormal_energy_balance0.27725405
144MP0003300_gastrointestinal_ulcer0.27196675
145MP0009115_abnormal_fat_cell0.26777679
146MP0002269_muscular_atrophy0.26145695
147MP0003724_increased_susceptibility_to0.24675538
148MP0002970_abnormal_white_adipose0.24366761
149MP0003221_abnormal_cardiomyocyte_apopto0.24188733
150MP0000639_abnormal_adrenal_gland0.24136637
151MP0000371_diluted_coat_color0.23654952
152MP0001944_abnormal_pancreas_morphology0.23341310

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.08906241
2Intrahepatic cholestasis (HP:0001406)5.57265429
3Hyperglycinuria (HP:0003108)5.32589150
4Gout (HP:0001997)5.21933780
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.10127313
6Abnormality of glutamine family amino acid metabolism (HP:0010902)5.07279583
7Xanthomatosis (HP:0000991)4.98018557
8Deep venous thrombosis (HP:0002625)4.91794165
9Abnormality of serine family amino acid metabolism (HP:0010894)4.91041109
10Abnormality of glycine metabolism (HP:0010895)4.91041109
11Ketosis (HP:0001946)4.74486312
12Hyperglycinemia (HP:0002154)4.72585249
13Hyperammonemia (HP:0001987)4.51510256
14Hypobetalipoproteinemia (HP:0003563)4.43208629
15Abnormality of aspartate family amino acid metabolism (HP:0010899)4.31991070
16Ketoacidosis (HP:0001993)4.19514946
17Abnormality of purine metabolism (HP:0004352)4.03740525
18Prolonged partial thromboplastin time (HP:0003645)4.01795205
19Proximal tubulopathy (HP:0000114)4.01006548
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.99139448
21Abnormality of fatty-acid metabolism (HP:0004359)3.96186455
22Hypoglycemic coma (HP:0001325)3.79892905
23Generalized aminoaciduria (HP:0002909)3.76314064
24Abnormality of nucleobase metabolism (HP:0010932)3.75811468
25Increased circulating renin level (HP:0000848)3.70524620
26Hyperuricemia (HP:0002149)3.69219627
27Increased purine levels (HP:0004368)3.69219627
28Hyperlipoproteinemia (HP:0010980)3.68240680
29Hypokalemic alkalosis (HP:0001949)3.67655079
30Delayed CNS myelination (HP:0002188)3.60163977
31Alkalosis (HP:0001948)3.55068849
32Hyperactive renin-angiotensin system (HP:0000841)3.39018447
33Metabolic alkalosis (HP:0200114)3.32882982
34Hypolipoproteinemia (HP:0010981)3.28862779
35Abnormality of dicarboxylic acid metabolism (HP:0010995)3.26802113
36Dicarboxylic aciduria (HP:0003215)3.26802113
37Complement deficiency (HP:0004431)3.24125563
38Abnormality of methionine metabolism (HP:0010901)3.24001619
39Abnormality of serum amino acid levels (HP:0003112)3.23698601
40Abnormality of pyrimidine metabolism (HP:0004353)3.19953354
41Joint hemorrhage (HP:0005261)3.18629869
42Hyperinsulinemic hypoglycemia (HP:0000825)3.17587103
43Metabolic acidosis (HP:0001942)3.15929597
44Fat malabsorption (HP:0002630)3.15494546
45Glycosuria (HP:0003076)3.11228183
46Abnormality of urine glucose concentration (HP:0011016)3.11228183
47Increased serum pyruvate (HP:0003542)3.09931960
48Polyuria (HP:0000103)3.09463344
49Abnormal urine output (HP:0012590)3.09247894
50Hypomagnesemia (HP:0002917)3.06317448
51Lethargy (HP:0001254)3.05783711
52Epidermoid cyst (HP:0200040)3.05683336
53Abnormality of vitamin metabolism (HP:0100508)3.04936104
54Abnormality of glycolysis (HP:0004366)3.04669068
55Acute encephalopathy (HP:0006846)2.98829348
56Vascular calcification (HP:0004934)2.97840481
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.95583582
58Hypothermia (HP:0002045)2.94227623
59Abnormality of the common coagulation pathway (HP:0010990)2.88561243
60Abnormality of chloride homeostasis (HP:0011422)2.87450098
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.85836676
62Abnormality of renal excretion (HP:0011036)2.84051734
63Pancreatic islet-cell hyperplasia (HP:0004510)2.83674557
64Hypoalphalipoproteinemia (HP:0003233)2.82113120
65Hepatic necrosis (HP:0002605)2.80430132
66Methylmalonic acidemia (HP:0002912)2.78185121
67Hyperbilirubinemia (HP:0002904)2.74536342
68Acute necrotizing encephalopathy (HP:0006965)2.73876368
69Hepatocellular carcinoma (HP:0001402)2.71079880
70Vomiting (HP:0002013)2.69169553
71Conjugated hyperbilirubinemia (HP:0002908)2.68795113
72Enlarged kidneys (HP:0000105)2.68096836
73Abnormality of proline metabolism (HP:0010907)2.67924624
74Hydroxyprolinuria (HP:0003080)2.67924624
75Abnormality of vitamin B metabolism (HP:0004340)2.65364467
76Cardiovascular calcification (HP:0011915)2.64093956
77Spontaneous abortion (HP:0005268)2.57823265
78Malnutrition (HP:0004395)2.57634697
79Cerebral edema (HP:0002181)2.57452647
80Abnormality of magnesium homeostasis (HP:0004921)2.55030464
81Progressive macrocephaly (HP:0004481)2.53144287
82Irritability (HP:0000737)2.53029943
83Spastic diplegia (HP:0001264)2.52935606
84Rickets (HP:0002748)2.52368365
85Symptomatic seizures (HP:0011145)2.47648186
86Abnormality of the intrinsic pathway (HP:0010989)2.46353051
87Abnormality of endocrine pancreas physiology (HP:0012093)2.41873063
88Abnormality of the pancreatic islet cells (HP:0006476)2.41873063
89Increased CSF lactate (HP:0002490)2.40617496
90Lipid accumulation in hepatocytes (HP:0006561)2.39714464
91Mitochondrial inheritance (HP:0001427)2.39023010
92Cholecystitis (HP:0001082)2.38354438
93Abnormal gallbladder physiology (HP:0012438)2.38354438
94Neonatal onset (HP:0003623)2.36920204
95Hyperphosphaturia (HP:0003109)2.36807897
96Increased hepatocellular lipid droplets (HP:0006565)2.36167472
97Hepatocellular necrosis (HP:0001404)2.35948355
98Abnormal mitochondria in muscle tissue (HP:0008316)2.35510894
99Nephrolithiasis (HP:0000787)2.32794108
100Steatorrhea (HP:0002570)2.32699990
101Hypercholesterolemia (HP:0003124)2.30935872
102Polydipsia (HP:0001959)2.30729473
103Abnormal drinking behavior (HP:0030082)2.30729473
104Abnormal enzyme/coenzyme activity (HP:0012379)2.30186098
105Late onset (HP:0003584)2.26066226
106Glomerulonephritis (HP:0000099)2.24468231
107Hyperglycemia (HP:0003074)2.23754035
108Renal tubular acidosis (HP:0001947)2.22848424
109Sensorimotor neuropathy (HP:0007141)2.22449185
110Abnormality of complement system (HP:0005339)2.22284352
111Renal salt wasting (HP:0000127)2.21414053
112Reduced antithrombin III activity (HP:0001976)2.17996631
113Abnormal biliary tract physiology (HP:0012439)2.17757134
114Bile duct proliferation (HP:0001408)2.17757134
115Megaloblastic anemia (HP:0001889)2.17268174
116Tetany (HP:0001281)2.16903575
117Nausea (HP:0002018)2.16335003
118Confusion (HP:0001289)2.15447898
119Hypoglycemic seizures (HP:0002173)2.12964853
120Abnormal urine phosphate concentration (HP:0012599)2.11731941
121Abnormality of renin-angiotensin system (HP:0000847)2.10634201
122Abnormality of alkaline phosphatase activity (HP:0004379)2.10057847
123Methylmalonic aciduria (HP:0012120)2.07779578
124Renal cortical cysts (HP:0000803)2.07379199
125Pancreatitis (HP:0001733)2.06810946
126Hyperaldosteronism (HP:0000859)2.06744627
127Abnormality of the vitamin B12 metabolism (HP:0004341)2.04350723
128Renal Fanconi syndrome (HP:0001994)2.00981924
129Hypophosphatemia (HP:0002148)1.99735131
130Hypokinesia (HP:0002375)1.95555205
131Abnormal cartilage morphology (HP:0002763)1.95480879
132Azoospermia (HP:0000027)1.92583057
133Hypophosphatemic rickets (HP:0004912)1.92260392
134Elevated alkaline phosphatase (HP:0003155)1.90486102
135Increased serum lactate (HP:0002151)1.87281686
136Opisthotonus (HP:0002179)1.86584708
137Lactic acidosis (HP:0003128)1.81231658
138CNS demyelination (HP:0007305)1.79348424
139Respiratory failure (HP:0002878)1.78183948
1403-Methylglutaconic aciduria (HP:0003535)1.75017561
141Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74580679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.93371110
2WNK45.61025309
3WNK35.60675408
4OXSR14.71875034
5MST44.33115883
6EIF2AK33.58436510
7STK38L2.99565193
8FGFR42.97539084
9SIK12.84443091
10ERN12.69285783
11MAP3K122.61014247
12NEK12.27317226
13BRSK22.27315121
14INSRR2.23388294
15VRK22.22237064
16PDK42.19684734
17PDK32.19684734
18STK392.14749408
19BUB12.12102993
20PBK2.11690209
21MST1R2.02013852
22TRIM281.96094351
23TNIK1.87260289
24TTK1.77831572
25ERBB41.77224848
26STK241.76319857
27PLK31.73481114
28BMPR1B1.68378392
29NUAK11.55357402
30VRK11.50299720
31PASK1.49498027
32PKN21.47244726
33ZAK1.45336042
34SGK2231.43863021
35SGK4941.43863021
36BCR1.42679842
37FLT31.40724502
38TSSK61.39098658
39ACVR1B1.37854193
40ABL21.32591586
41PDK21.31499203
42LATS11.29741799
43GRK11.28604737
44MAP4K21.27962399
45TAOK31.27595307
46FGFR31.23286863
47MAPK111.22832961
48MAP2K41.22740118
49PINK11.22326132
50TRIB31.13541387
51MET1.09000386
52FRK1.08811730
53MKNK21.08486533
54TAF11.07016456
55LMTK21.02705601
56PIK3CG1.00974258
57NLK1.00933506
58ERBB30.99334781
59WEE10.98511747
60SGK20.98041727
61SGK30.97439287
62NME10.95557651
63GRK60.93030871
64MAP3K30.93018993
65SRPK10.92022971
66CASK0.91802147
67FGFR10.91127245
68PLK10.90354223
69STK380.87417795
70PRKCE0.85953086
71PTK60.85813046
72NEK90.84527471
73BRSK10.84522005
74MAPK150.84180866
75GSK3A0.83630552
76MAP3K70.82173949
77PRKAA20.80487483
78DYRK1B0.74589336
79EIF2AK10.72751993
80MAPKAPK30.72376980
81PRKAA10.71822241
82ADRBK20.70880557
83MKNK10.68355988
84KDR0.68051875
85IRAK20.67403934
86CDC70.67176256
87PRKCZ0.66768585
88PLK20.66203533
89DAPK10.64667630
90EIF2AK20.63596577
91CDK80.63372846
92MAP2K30.62567299
93IRAK30.62513263
94TIE10.61364369
95EPHA20.61342345
96PTK20.60907674
97TLK10.58417213
98WNK10.55634007
99DAPK20.54306029
100AURKB0.53906474
101TRPM70.53890660
102MAP3K90.53200685
103JAK20.51869999
104LRRK20.51808072
105PRKACG0.51241813
106CSNK2A20.50089519
107PIK3CA0.49675830
108MAP3K110.49462932
109FGFR20.49390177
110DAPK30.48167466
111ATM0.48050423
112PLK40.47761286
113PHKG10.47011734
114PHKG20.47011734
115IRAK10.45249983
116EPHB10.44669074
117CSNK1G30.44504602
118CSNK2A10.43835260
119CDK30.43206397
120NME20.42938143
121LATS20.42683968
122PDPK10.41990154
123STK40.41707593
124MAP3K20.40515577
125TGFBR20.39589385
126TAOK20.39123230
127FER0.38529067
128TYK20.38181507
129PAK30.37768532
130MYLK0.37101949
131LIMK10.36851068
132EPHA40.36021910
133CDK90.35071109
134MAPK40.35044791
135YES10.34798867
136CSNK1E0.34474839
137PRKACB0.34407147
138MAP2K10.33673437
139NEK60.33398793
140MAP2K60.33057428
141RIPK10.32828343
142MAPK120.32216826
143PRKG10.31444050
144ERBB20.30134085
145CAMK2G0.29392801
146MELK0.29253204
147BMPR20.29129866
148PRKCG0.28993548
149MTOR0.28773148
150ALK0.28209412
151CDK60.27374815
152PRKCI0.25400987
153SGK10.25104373
154PAK40.24737095
155AKT20.21986008
156PRKCA0.21131308
157CSNK1G10.21035629
158MAP3K50.19633903
159MAP3K100.19520024
160MAP2K20.19456264
161PDGFRA0.19401094
162STK30.19113109
163BMX0.18927266
164STK160.18850609
165CDK40.18415690
166PDK10.17544929
167AKT30.17185918
168IGF1R0.16481590
169PRKACA0.15559659
170ICK0.14676297

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.52243370
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41981712
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.09896811
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09124259
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.90983893
6Nitrogen metabolism_Homo sapiens_hsa009102.84364385
7Butanoate metabolism_Homo sapiens_hsa006502.81546861
8Fatty acid degradation_Homo sapiens_hsa000712.67272574
9Tryptophan metabolism_Homo sapiens_hsa003802.66558915
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60946109
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60190650
12Propanoate metabolism_Homo sapiens_hsa006402.58620548
13Arginine biosynthesis_Homo sapiens_hsa002202.54842234
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.47188658
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34955252
16Peroxisome_Homo sapiens_hsa041462.32247651
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24684282
18Protein export_Homo sapiens_hsa030602.12954693
19Fatty acid metabolism_Homo sapiens_hsa012121.97292903
20Pyruvate metabolism_Homo sapiens_hsa006201.93736883
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.91158160
22beta-Alanine metabolism_Homo sapiens_hsa004101.88634447
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85732328
24Complement and coagulation cascades_Homo sapiens_hsa046101.78989442
25PPAR signaling pathway_Homo sapiens_hsa033201.74809767
26Proteasome_Homo sapiens_hsa030501.74409974
27Histidine metabolism_Homo sapiens_hsa003401.66402690
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63941102
29Chemical carcinogenesis_Homo sapiens_hsa052041.61029682
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60726331
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60099933
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59387123
33Sulfur metabolism_Homo sapiens_hsa009201.57970157
34Selenocompound metabolism_Homo sapiens_hsa004501.56465550
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55266696
36Carbon metabolism_Homo sapiens_hsa012001.55025478
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.54781570
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.53051264
39Bile secretion_Homo sapiens_hsa049761.49823748
40Phenylalanine metabolism_Homo sapiens_hsa003601.49367345
41Retinol metabolism_Homo sapiens_hsa008301.37931097
42Fatty acid elongation_Homo sapiens_hsa000621.37437256
43Biosynthesis of amino acids_Homo sapiens_hsa012301.36819277
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30703727
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.30557049
46Starch and sucrose metabolism_Homo sapiens_hsa005001.25461470
47Arginine and proline metabolism_Homo sapiens_hsa003301.23426063
48Vitamin digestion and absorption_Homo sapiens_hsa049771.22881366
49Tyrosine metabolism_Homo sapiens_hsa003501.22108043
50Folate biosynthesis_Homo sapiens_hsa007901.19137173
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13896513
52Caffeine metabolism_Homo sapiens_hsa002321.08467845
53Glutathione metabolism_Homo sapiens_hsa004801.05715912
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03210248
55Lysine degradation_Homo sapiens_hsa003100.99693995
56Mismatch repair_Homo sapiens_hsa034300.99603689
57Steroid biosynthesis_Homo sapiens_hsa001000.98584684
58Staphylococcus aureus infection_Homo sapiens_hsa051500.92419666
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.91848169
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91105877
61ABC transporters_Homo sapiens_hsa020100.85260687
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78895270
63Fat digestion and absorption_Homo sapiens_hsa049750.77090709
64Sulfur relay system_Homo sapiens_hsa041220.76646283
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76239285
66Glycerolipid metabolism_Homo sapiens_hsa005610.75142168
67One carbon pool by folate_Homo sapiens_hsa006700.74331090
68Pentose phosphate pathway_Homo sapiens_hsa000300.71766404
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70812811
70Vitamin B6 metabolism_Homo sapiens_hsa007500.69886875
71RNA polymerase_Homo sapiens_hsa030200.68460038
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63557126
73Basal transcription factors_Homo sapiens_hsa030220.60598350
74Homologous recombination_Homo sapiens_hsa034400.57790615
75Metabolic pathways_Homo sapiens_hsa011000.57436888
76Huntingtons disease_Homo sapiens_hsa050160.55596952
77Non-homologous end-joining_Homo sapiens_hsa034500.55566785
78Nucleotide excision repair_Homo sapiens_hsa034200.55071187
79RNA degradation_Homo sapiens_hsa030180.54545092
80Circadian rhythm_Homo sapiens_hsa047100.52393833
81Fructose and mannose metabolism_Homo sapiens_hsa000510.52225969
82N-Glycan biosynthesis_Homo sapiens_hsa005100.47969651
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40857405
84Ribosome_Homo sapiens_hsa030100.35291766
85Pyrimidine metabolism_Homo sapiens_hsa002400.32294651
86Purine metabolism_Homo sapiens_hsa002300.32226623
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29439478
88RNA transport_Homo sapiens_hsa030130.28790047
89Galactose metabolism_Homo sapiens_hsa000520.28763498
90Sphingolipid metabolism_Homo sapiens_hsa006000.27246396
91DNA replication_Homo sapiens_hsa030300.26370185
92Fatty acid biosynthesis_Homo sapiens_hsa000610.23455881
93Collecting duct acid secretion_Homo sapiens_hsa049660.20959960
94Fanconi anemia pathway_Homo sapiens_hsa034600.16977113
95Insulin resistance_Homo sapiens_hsa049310.16111420
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14670619
97Other glycan degradation_Homo sapiens_hsa005110.14097049
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.13252365
99Protein digestion and absorption_Homo sapiens_hsa049740.12816088
100Oxidative phosphorylation_Homo sapiens_hsa001900.11678533
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10648360
102Mineral absorption_Homo sapiens_hsa049780.09361605
103Glucagon signaling pathway_Homo sapiens_hsa049220.08101453
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05883066
105Renin-angiotensin system_Homo sapiens_hsa046140.05280384
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.04982016
107AMPK signaling pathway_Homo sapiens_hsa041520.03093959
108Thyroid hormone synthesis_Homo sapiens_hsa049180.01327294
109Prion diseases_Homo sapiens_hsa050200.01270462
110Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1646415
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1636033
112Insulin signaling pathway_Homo sapiens_hsa04910-0.1565056
113Alzheimers disease_Homo sapiens_hsa05010-0.1490779
114Regulation of autophagy_Homo sapiens_hsa04140-0.0781752
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0675230
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0646338
117Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0537182
118Lysosome_Homo sapiens_hsa04142-0.0528625
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0382607
120Parkinsons disease_Homo sapiens_hsa05012-0.0239912
121Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0152214
122Linoleic acid metabolism_Homo sapiens_hsa00591-0.0085154
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0022094

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