CRYZL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.00038151
2neuron cell-cell adhesion (GO:0007158)4.97081178
3behavioral response to nicotine (GO:0035095)4.87306025
4presynaptic membrane organization (GO:0097090)4.54150197
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.43356979
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24821308
7pyrimidine nucleobase catabolic process (GO:0006208)4.18906788
8platelet dense granule organization (GO:0060155)4.06610779
9ATP synthesis coupled proton transport (GO:0015986)4.05993798
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05993798
11synaptic vesicle exocytosis (GO:0016079)4.01929741
12vocalization behavior (GO:0071625)3.96862974
13chaperone-mediated protein transport (GO:0072321)3.87110421
14negative regulation of synaptic transmission, GABAergic (GO:0032229)3.86569810
15postsynaptic membrane organization (GO:0001941)3.85499044
16protein neddylation (GO:0045116)3.83863849
17ATP hydrolysis coupled proton transport (GO:0015991)3.82631036
18energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.82631036
19transferrin transport (GO:0033572)3.80633407
20gamma-aminobutyric acid signaling pathway (GO:0007214)3.80283430
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77155553
22protein localization to synapse (GO:0035418)3.76459856
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.76192785
24dopamine transport (GO:0015872)3.75467048
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.69330110
26epithelial cilium movement (GO:0003351)3.67722510
27protein complex biogenesis (GO:0070271)3.67525721
28startle response (GO:0001964)3.64868118
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61880053
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.61880053
31NADH dehydrogenase complex assembly (GO:0010257)3.61880053
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.59018937
33respiratory electron transport chain (GO:0022904)3.55523809
34neurotransmitter uptake (GO:0001504)3.54261760
35neuron-neuron synaptic transmission (GO:0007270)3.54171083
36ferric iron transport (GO:0015682)3.52801162
37trivalent inorganic cation transport (GO:0072512)3.52801162
38neural tube formation (GO:0001841)3.51251010
39response to pheromone (GO:0019236)3.50659968
40nucleobase catabolic process (GO:0046113)3.48559746
41electron transport chain (GO:0022900)3.46640558
42negative regulation of neurotransmitter transport (GO:0051589)3.44456767
43synaptic transmission, glutamatergic (GO:0035249)3.41434748
44glutamate receptor signaling pathway (GO:0007215)3.39582615
45regulation of synaptic vesicle exocytosis (GO:2000300)3.39397139
46sequestering of actin monomers (GO:0042989)3.39084811
47phagosome maturation (GO:0090382)3.34374674
48positive regulation of synapse assembly (GO:0051965)3.33868610
49neuronal action potential propagation (GO:0019227)3.32714195
50protein localization to cilium (GO:0061512)3.32511298
51long-chain fatty acid biosynthetic process (GO:0042759)3.28172086
52intraciliary transport (GO:0042073)3.27507914
53DNA deamination (GO:0045006)3.25375682
54regulation of glutamate receptor signaling pathway (GO:1900449)3.21915757
55protein-cofactor linkage (GO:0018065)3.20210892
56preassembly of GPI anchor in ER membrane (GO:0016254)3.15550852
57mitochondrial respiratory chain complex assembly (GO:0033108)3.15261355
58regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14945768
59transmission of nerve impulse (GO:0019226)3.13924593
60gamma-aminobutyric acid transport (GO:0015812)3.13145497
61regulation of synaptic vesicle transport (GO:1902803)3.09410138
62neurotransmitter-gated ion channel clustering (GO:0072578)3.08962569
63fucose catabolic process (GO:0019317)3.08174540
64L-fucose metabolic process (GO:0042354)3.08174540
65L-fucose catabolic process (GO:0042355)3.08174540
66central nervous system myelination (GO:0022010)3.07620164
67axon ensheathment in central nervous system (GO:0032291)3.07620164
68detection of light stimulus involved in visual perception (GO:0050908)3.07222521
69detection of light stimulus involved in sensory perception (GO:0050962)3.07222521
70axoneme assembly (GO:0035082)3.06095701
71protein polyglutamylation (GO:0018095)3.04648786
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03395894
73regulation of glutamate secretion (GO:0014048)3.03028861
74anterograde synaptic vesicle transport (GO:0048490)3.02344626
75negative regulation of telomere maintenance (GO:0032205)3.01342393
76long-term synaptic potentiation (GO:0060291)3.00873187
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99115698
78prenylation (GO:0097354)2.98877403
79protein prenylation (GO:0018342)2.98877403
80neuron recognition (GO:0008038)2.98222830
81DNA double-strand break processing (GO:0000729)2.98162734
82respiratory chain complex IV assembly (GO:0008535)2.97949465
83water-soluble vitamin biosynthetic process (GO:0042364)2.96115504
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.94730535
85cilium morphogenesis (GO:0060271)2.92938199
86cilium movement (GO:0003341)2.92229734
87regulation of cilium movement (GO:0003352)2.91987394
88response to histamine (GO:0034776)2.91025791
89GPI anchor metabolic process (GO:0006505)2.90166655
90cilium organization (GO:0044782)2.89248097
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88108934
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88108934
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84944439
94organelle disassembly (GO:1903008)2.84758655
95protein deneddylation (GO:0000338)2.83310465
96cilium assembly (GO:0042384)2.83011067
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82733238
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.81921694
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.81595872
100regulation of catecholamine metabolic process (GO:0042069)2.81505555
101regulation of dopamine metabolic process (GO:0042053)2.81505555
102striatum development (GO:0021756)2.80447158
103regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80337414
104mechanosensory behavior (GO:0007638)2.79743962
105negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77483988
106glutamate secretion (GO:0014047)2.74730353
107cytochrome complex assembly (GO:0017004)2.73720457
108limb bud formation (GO:0060174)2.72966536
109somite development (GO:0061053)2.72936381
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72921020
111catecholamine transport (GO:0051937)2.71955442
112synaptic vesicle endocytosis (GO:0048488)2.71031128
113cornea development in camera-type eye (GO:0061303)2.70646270
114hydrogen ion transmembrane transport (GO:1902600)2.69499796
115photoreceptor cell maintenance (GO:0045494)2.68234340
116regulation of postsynaptic membrane potential (GO:0060078)2.67979106
117cullin deneddylation (GO:0010388)2.67920872
118cellular ketone body metabolic process (GO:0046950)2.67517398
119neurotransmitter secretion (GO:0007269)2.66019710
120dendrite development (GO:0016358)2.65414666
121mannosylation (GO:0097502)2.65349809
122retinal ganglion cell axon guidance (GO:0031290)2.65264340
123inner ear receptor stereocilium organization (GO:0060122)2.65223811
124regulation of synapse assembly (GO:0051963)2.64900555
125neurotransmitter transport (GO:0006836)2.63428623
126establishment of synaptic vesicle localization (GO:0097480)2.63417407
127synaptic vesicle transport (GO:0048489)2.63417407
128cerebellar granule cell differentiation (GO:0021707)2.63223864
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.62429132
130regulation of neurotransmitter secretion (GO:0046928)2.60896687
131positive regulation of protein homodimerization activity (GO:0090073)2.60862353
132synaptic transmission, dopaminergic (GO:0001963)2.60315674
133synaptic transmission, cholinergic (GO:0007271)2.59961008
134response to cocaine (GO:0042220)2.59633728
135nonmotile primary cilium assembly (GO:0035058)2.58614072
136regulation of synaptic transmission, GABAergic (GO:0032228)2.58144467
137kynurenine metabolic process (GO:0070189)2.57596607
138GTP biosynthetic process (GO:0006183)2.56358077
139replication fork processing (GO:0031297)2.55997382
140proton transport (GO:0015992)2.55848236
141behavioral response to ethanol (GO:0048149)2.54864286
142indolalkylamine metabolic process (GO:0006586)2.54165122
143positive regulation of mitochondrial fission (GO:0090141)2.53540366
144regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.52999193
145GPI anchor biosynthetic process (GO:0006506)2.52785239
146retinal cone cell development (GO:0046549)2.51726911
147anterograde axon cargo transport (GO:0008089)2.51271387
148hydrogen transport (GO:0006818)2.50641233
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50279252
150regulation of voltage-gated calcium channel activity (GO:1901385)2.50117004
151regulation of neurotransmitter transport (GO:0051588)2.49057667
152regulation of amino acid transport (GO:0051955)2.48847652
153photoreceptor cell development (GO:0042461)2.48770333
154synapse assembly (GO:0007416)2.48054081
155membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47912918
156regulation of vesicle fusion (GO:0031338)2.47732056
157regulation of protein kinase A signaling (GO:0010738)2.47170857
158ketone body metabolic process (GO:1902224)2.47116997
159substantia nigra development (GO:0021762)2.46826356
160regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46113979
161negative regulation of dendrite morphogenesis (GO:0050774)2.44890868
162kidney morphogenesis (GO:0060993)2.43557673
163S-adenosylmethionine metabolic process (GO:0046500)2.43411029
164adenosine metabolic process (GO:0046085)2.41928091
165tryptophan catabolic process (GO:0006569)2.41846188
166indole-containing compound catabolic process (GO:0042436)2.41846188
167indolalkylamine catabolic process (GO:0046218)2.41846188
168regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.41361132
169head development (GO:0060322)2.40551846
170intracellular protein transmembrane import (GO:0044743)2.38627188
171proteasome assembly (GO:0043248)2.38625110
172base-excision repair, AP site formation (GO:0006285)2.38487206
173C-terminal protein lipidation (GO:0006501)2.38449492
174positive regulation of oligodendrocyte differentiation (GO:0048714)2.37842042
175cilium or flagellum-dependent cell motility (GO:0001539)2.37674150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.45638019
2EZH2_22144423_ChIP-Seq_EOC_Human3.91124128
3ZNF274_21170338_ChIP-Seq_K562_Hela3.81468391
4TAF15_26573619_Chip-Seq_HEK293_Human3.05907717
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78454317
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64090634
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.52503976
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46804043
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46408649
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40000217
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39461989
12FUS_26573619_Chip-Seq_HEK293_Human2.29634742
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26398508
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.24503725
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15259855
16P300_19829295_ChIP-Seq_ESCs_Human2.13023530
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11882356
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.08986301
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08527610
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08113262
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07627429
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.06719899
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00308559
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94862597
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89894594
26VDR_22108803_ChIP-Seq_LS180_Human1.89691521
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.86499600
28REST_21632747_ChIP-Seq_MESCs_Mouse1.85912442
29* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82416902
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.81961125
31ELK1_19687146_ChIP-ChIP_HELA_Human1.81708468
32SMAD4_21799915_ChIP-Seq_A2780_Human1.76790274
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74921151
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74325187
35ER_23166858_ChIP-Seq_MCF-7_Human1.73064828
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69996891
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67877293
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67877293
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62907494
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62516481
41VDR_23849224_ChIP-Seq_CD4+_Human1.61052880
42TP53_22573176_ChIP-Seq_HFKS_Human1.60931936
43RNF2_27304074_Chip-Seq_NSC_Mouse1.60654342
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59060269
45MYC_18940864_ChIP-ChIP_HL60_Human1.58119808
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56746372
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56644646
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.56431167
49EWS_26573619_Chip-Seq_HEK293_Human1.56179668
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.55805726
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52921979
52IGF1R_20145208_ChIP-Seq_DFB_Human1.52002562
53AR_21572438_ChIP-Seq_LNCaP_Human1.50115855
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48932642
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48242931
56CBP_20019798_ChIP-Seq_JUKART_Human1.48242931
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.47175142
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46703119
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46065222
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.45583529
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.44856582
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.42005990
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41873683
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39833651
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39520529
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39245647
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38326369
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37563837
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.37280111
70P53_22387025_ChIP-Seq_ESCs_Mouse1.34221301
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34114831
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33897073
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30963691
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29565260
75BCAT_22108803_ChIP-Seq_LS180_Human1.29106760
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.28795841
77NANOG_19829295_ChIP-Seq_ESCs_Human1.28768074
78SOX2_19829295_ChIP-Seq_ESCs_Human1.28768074
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.28474189
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27441216
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26684559
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.26362595
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25601941
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25578856
85JUN_21703547_ChIP-Seq_K562_Human1.24772650
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24598124
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24598124
88AR_25329375_ChIP-Seq_VCAP_Human1.24229809
89* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23997361
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23528719
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23279963
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23175820
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.23155217
94IRF1_19129219_ChIP-ChIP_H3396_Human1.23064523
95* TAL1_26923725_Chip-Seq_HPCs_Mouse1.21465387
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21146939
97* TCF4_22108803_ChIP-Seq_LS180_Human1.19137877
98P300_18555785_Chip-Seq_ESCs_Mouse1.18810611
99ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18448941
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18003960
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17807075
102SOX2_18555785_Chip-Seq_ESCs_Mouse1.17338196
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16534679
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16293702
105JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15746771
106* TCF4_23295773_ChIP-Seq_U87_Human1.15085293
107FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15085123
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.15085123
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.14842840
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14444767
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14279773
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13359101
113NCOR_22424771_ChIP-Seq_293T_Human1.13221946
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12029260
115RUNX2_22187159_ChIP-Seq_PCA_Human1.11552995
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11136098
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10750680
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10696058
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10256921
120STAT3_23295773_ChIP-Seq_U87_Human1.09950807
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.09485189
122* AR_20517297_ChIP-Seq_VCAP_Human1.08680545
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08361294
124NOTCH1_21737748_ChIP-Seq_TLL_Human1.07181768
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.07115411
126NMYC_18555785_Chip-Seq_ESCs_Mouse1.06744595
127PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06580329
128RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06105920
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05396690
130E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05304811
131SMAD_19615063_ChIP-ChIP_OVARY_Human1.04973617
132FOXP3_21729870_ChIP-Seq_TREG_Human1.04925636
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04772842
134ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04010213
135EZH2_27294783_Chip-Seq_NPCs_Mouse1.03774639
136FLI1_21867929_ChIP-Seq_TH2_Mouse1.02781076
137RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01568806
138TP63_19390658_ChIP-ChIP_HaCaT_Human1.00200902
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99680213
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.98187028
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97862297
142* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97106802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.37070719
2MP0004859_abnormal_synaptic_plasticity3.16666615
3MP0003635_abnormal_synaptic_transmissio2.96685800
4MP0001529_abnormal_vocalization2.96592430
5MP0009745_abnormal_behavioral_response2.95865624
6MP0001188_hyperpigmentation2.88412371
7MP0002064_seizures2.80913632
8MP0009046_muscle_twitch2.69276816
9MP0001968_abnormal_touch/_nociception2.68342777
10MP0002102_abnormal_ear_morphology2.67455783
11MP0002736_abnormal_nociception_after2.60328496
12MP0002272_abnormal_nervous_system2.58539806
13MP0001905_abnormal_dopamine_level2.52635219
14MP0002572_abnormal_emotion/affect_behav2.49935560
15MP0002063_abnormal_learning/memory/cond2.44192114
16MP0002735_abnormal_chemical_nociception2.30780729
17MP0002734_abnormal_mechanical_nocicepti2.30646537
18MP0005171_absent_coat_pigmentation2.29805477
19MP0006276_abnormal_autonomic_nervous2.29506231
20MP0004270_analgesia2.24753064
21MP0001501_abnormal_sleep_pattern2.19156505
22MP0001486_abnormal_startle_reflex2.18978696
23MP0004142_abnormal_muscle_tone2.10189159
24MP0005646_abnormal_pituitary_gland2.09139390
25MP0005423_abnormal_somatic_nervous2.06355642
26MP0001440_abnormal_grooming_behavior2.04282280
27MP0002067_abnormal_sensory_capabilities1.95416787
28MP0001984_abnormal_olfaction1.89832423
29MP0002822_catalepsy1.89155899
30MP0008789_abnormal_olfactory_epithelium1.85208914
31MP0000569_abnormal_digit_pigmentation1.82798649
32MP0002876_abnormal_thyroid_physiology1.82294362
33MP0001970_abnormal_pain_threshold1.79600416
34MP0005645_abnormal_hypothalamus_physiol1.78931580
35MP0005084_abnormal_gallbladder_morpholo1.78088842
36MP0003136_yellow_coat_color1.74259454
37MP0004133_heterotaxia1.72835921
38MP0003122_maternal_imprinting1.72485194
39MP0003195_calcinosis1.69424046
40MP0003011_delayed_dark_adaptation1.61427734
41MP0004924_abnormal_behavior1.61240972
42MP0005386_behavior/neurological_phenoty1.61240972
43MP0003787_abnormal_imprinting1.60135875
44MP0010386_abnormal_urinary_bladder1.59870994
45MP0001986_abnormal_taste_sensitivity1.59288930
46MP0005551_abnormal_eye_electrophysiolog1.59285001
47MP0000778_abnormal_nervous_system1.58400793
48MP0002733_abnormal_thermal_nociception1.56001165
49MP0002557_abnormal_social/conspecific_i1.45066238
50MP0008058_abnormal_DNA_repair1.43791735
51MP0002653_abnormal_ependyma_morphology1.42776088
52MP0002638_abnormal_pupillary_reflex1.39360720
53MP0002184_abnormal_innervation1.37368811
54MP0008995_early_reproductive_senescence1.33648279
55MP0001502_abnormal_circadian_rhythm1.32190405
56MP0002928_abnormal_bile_duct1.32055804
57MP0002751_abnormal_autonomic_nervous1.29180941
58MP0000920_abnormal_myelination1.27410117
59MP0003879_abnormal_hair_cell1.25166593
60MP0003183_abnormal_peptide_metabolism1.24072674
61MP0000427_abnormal_hair_cycle1.21024059
62MP0008260_abnormal_autophagy1.20597592
63MP0002234_abnormal_pharynx_morphology1.20482845
64MP0006292_abnormal_olfactory_placode1.20106646
65MP0002066_abnormal_motor_capabilities/c1.17770322
66MP0002882_abnormal_neuron_morphology1.17003010
67MP0005409_darkened_coat_color1.16967291
68MP0004742_abnormal_vestibular_system1.16692505
69MP0005379_endocrine/exocrine_gland_phen1.16354046
70MP0008875_abnormal_xenobiotic_pharmacok1.16000500
71MP0001293_anophthalmia1.13816734
72MP0008569_lethality_at_weaning1.12336187
73MP0002229_neurodegeneration1.10726361
74MP0001963_abnormal_hearing_physiology1.08663305
75MP0005195_abnormal_posterior_eye1.07778452
76MP0002837_dystrophic_cardiac_calcinosis1.07681647
77MP0002095_abnormal_skin_pigmentation1.07190520
78MP0000049_abnormal_middle_ear1.05999739
79MP0000631_abnormal_neuroendocrine_gland1.04965696
80MP0004145_abnormal_muscle_electrophysio1.04764210
81MP0000372_irregular_coat_pigmentation1.02752963
82MP0009379_abnormal_foot_pigmentation1.01297509
83MP0004147_increased_porphyrin_level0.99681506
84MP0000955_abnormal_spinal_cord0.99548347
85MP0005389_reproductive_system_phenotype0.99468575
86MP0002160_abnormal_reproductive_system0.98125821
87MP0001485_abnormal_pinna_reflex0.96411686
88MP0001177_atelectasis0.95881971
89MP0002163_abnormal_gland_morphology0.95779693
90MP0003329_amyloid_beta_deposits0.95603269
91MP0009697_abnormal_copulation0.95418602
92MP0003890_abnormal_embryonic-extraembry0.95190388
93MP0004811_abnormal_neuron_physiology0.94592538
94MP0005075_abnormal_melanosome_morpholog0.94239444
95MP0003646_muscle_fatigue0.93799776
96MP0005391_vision/eye_phenotype0.92955855
97MP0005174_abnormal_tail_pigmentation0.92798477
98MP0001919_abnormal_reproductive_system0.92521423
99MP0005253_abnormal_eye_physiology0.92173196
100MP0003631_nervous_system_phenotype0.91797778
101MP0000015_abnormal_ear_pigmentation0.91458340
102MP0003633_abnormal_nervous_system0.89945217
103MP0000647_abnormal_sebaceous_gland0.89851676
104MP0003634_abnormal_glial_cell0.89321713
105MP0002752_abnormal_somatic_nervous0.88859778
106MP0000026_abnormal_inner_ear0.87999625
107MP0009780_abnormal_chondrocyte_physiolo0.87894473
108MP0003137_abnormal_impulse_conducting0.87663751
109MP0001324_abnormal_eye_pigmentation0.87443272
110MP0004043_abnormal_pH_regulation0.87268102
111MP0005410_abnormal_fertilization0.87234828
112MP0001664_abnormal_digestion0.86969658
113MP0000516_abnormal_urinary_system0.86469252
114MP0005367_renal/urinary_system_phenotyp0.86469252
115MP0008872_abnormal_physiological_respon0.85676559
116MP0004215_abnormal_myocardial_fiber0.84833171
117MP0003937_abnormal_limbs/digits/tail_de0.83768937
118MP0003718_maternal_effect0.82315567
119MP0002277_abnormal_respiratory_mucosa0.80932636
120MP0006072_abnormal_retinal_apoptosis0.80842720
121MP0002282_abnormal_trachea_morphology0.80278713
122MP0003632_abnormal_nervous_system0.80204095
123MP0003121_genomic_imprinting0.77585763
124MP0002152_abnormal_brain_morphology0.76411521
125MP0008004_abnormal_stomach_pH0.76178626
126MP0000681_abnormal_thyroid_gland0.76178311
127MP0000013_abnormal_adipose_tissue0.73494677
128MP0002090_abnormal_vision0.70066154
129MP0002069_abnormal_eating/drinking_beha0.68078188
130MP0002938_white_spotting0.67995908
131MP0005535_abnormal_body_temperature0.65548803
132MP0005499_abnormal_olfactory_system0.64874305
133MP0005394_taste/olfaction_phenotype0.64874305
134MP0003690_abnormal_glial_cell0.64237755
135MP0006035_abnormal_mitochondrial_morpho0.63795202
136MP0004885_abnormal_endolymph0.62310455
137MP0001943_abnormal_respiration0.61489880
138MP0008877_abnormal_DNA_methylation0.60249607

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.43736911
2Acute necrotizing encephalopathy (HP:0006965)4.94074682
3Abnormal mitochondria in muscle tissue (HP:0008316)4.49229647
4Progressive macrocephaly (HP:0004481)4.23955540
5Mitochondrial inheritance (HP:0001427)4.23108426
6Atonic seizures (HP:0010819)4.22694477
7Epileptic encephalopathy (HP:0200134)3.91690345
8Medial flaring of the eyebrow (HP:0010747)3.65481829
9Increased CSF lactate (HP:0002490)3.65219173
10Acute encephalopathy (HP:0006846)3.65161387
11Hepatocellular necrosis (HP:0001404)3.54636526
12Gait imbalance (HP:0002141)3.46152951
13Febrile seizures (HP:0002373)3.43551154
14Hyperventilation (HP:0002883)3.41951715
15Abnormal hair whorl (HP:0010721)3.35335126
16Congenital primary aphakia (HP:0007707)3.32624177
17Nephrogenic diabetes insipidus (HP:0009806)3.17286150
18Hypothermia (HP:0002045)3.17125995
19Focal seizures (HP:0007359)3.14858516
20Abnormality of the renal medulla (HP:0100957)3.06598001
21Increased serum pyruvate (HP:0003542)3.04700722
22Abnormality of glycolysis (HP:0004366)3.04700722
23Optic disc pallor (HP:0000543)3.02954398
24Absence seizures (HP:0002121)2.98405572
25Abnormal ciliary motility (HP:0012262)2.98037969
26Abnormality of the renal cortex (HP:0011035)2.97798979
27Congenital stationary night blindness (HP:0007642)2.96834570
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.95448566
29Absent/shortened dynein arms (HP:0200106)2.95448566
30Dialeptic seizures (HP:0011146)2.95327249
31Increased hepatocellular lipid droplets (HP:0006565)2.83718569
32Chronic hepatic failure (HP:0100626)2.82840451
33Renal cortical cysts (HP:0000803)2.80716092
34Myokymia (HP:0002411)2.78729642
35Vaginal atresia (HP:0000148)2.78477059
36Pancreatic fibrosis (HP:0100732)2.76367117
37Renal Fanconi syndrome (HP:0001994)2.76080223
38Genital tract atresia (HP:0001827)2.75556087
39Type II lissencephaly (HP:0007260)2.72142674
40True hermaphroditism (HP:0010459)2.69569230
41Limb dystonia (HP:0002451)2.68100052
42Hepatic necrosis (HP:0002605)2.67653268
43Scanning speech (HP:0002168)2.67413992
44Broad-based gait (HP:0002136)2.66783082
45Abnormal respiratory motile cilium morphology (HP:0005938)2.64690106
46Abnormal respiratory epithelium morphology (HP:0012253)2.64690106
47Neuroendocrine neoplasm (HP:0100634)2.60244219
48Progressive cerebellar ataxia (HP:0002073)2.58207172
49Leukodystrophy (HP:0002415)2.57831993
50Abnormal respiratory motile cilium physiology (HP:0012261)2.54162154
51Pheochromocytoma (HP:0002666)2.52429174
52Cystic liver disease (HP:0006706)2.49280174
53Lissencephaly (HP:0001339)2.47101383
543-Methylglutaconic aciduria (HP:0003535)2.46271227
55Exercise intolerance (HP:0003546)2.44605077
56Generalized tonic-clonic seizures (HP:0002069)2.43992186
57Poor coordination (HP:0002370)2.40194549
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37745591
59Abnormality of alanine metabolism (HP:0010916)2.37745591
60Hyperalaninemia (HP:0003348)2.37745591
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35809141
62Attenuation of retinal blood vessels (HP:0007843)2.33998668
63Microvesicular hepatic steatosis (HP:0001414)2.33145759
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.30628818
65Abolished electroretinogram (ERG) (HP:0000550)2.28478995
66Sclerocornea (HP:0000647)2.28188865
67Molar tooth sign on MRI (HP:0002419)2.27707307
68Abnormality of midbrain morphology (HP:0002418)2.27707307
69Abnormality of the labia minora (HP:0012880)2.27650176
70Respiratory failure (HP:0002878)2.25161769
71Lactic acidosis (HP:0003128)2.21122132
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21026352
73Abnormality of renal resorption (HP:0011038)2.20632727
74Congenital, generalized hypertrichosis (HP:0004540)2.20521754
75Pachygyria (HP:0001302)2.20363555
76Gaze-evoked nystagmus (HP:0000640)2.19696027
77Postaxial foot polydactyly (HP:0001830)2.18397185
78Visual hallucinations (HP:0002367)2.17986624
79Anencephaly (HP:0002323)2.17452523
80Lipid accumulation in hepatocytes (HP:0006561)2.17446474
81Short tibia (HP:0005736)2.16846634
82Pancreatic cysts (HP:0001737)2.13714699
83Bile duct proliferation (HP:0001408)2.13538807
84Abnormal biliary tract physiology (HP:0012439)2.13538807
85Congenital hepatic fibrosis (HP:0002612)2.13532857
86Retinal dysplasia (HP:0007973)2.11105885
87Increased serum lactate (HP:0002151)2.10035099
88Nephronophthisis (HP:0000090)2.09207397
89Aplasia/Hypoplasia of the lens (HP:0008063)2.08719531
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06748412
91Postaxial hand polydactyly (HP:0001162)2.06595878
92Poor suck (HP:0002033)2.05433459
93Tubular atrophy (HP:0000092)2.05141226
94Intestinal atresia (HP:0011100)2.04279444
95Colon cancer (HP:0003003)2.03562736
96Cerebral edema (HP:0002181)2.02470472
97X-linked dominant inheritance (HP:0001423)2.00882156
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98139514
99Stomach cancer (HP:0012126)1.97989781
100Abnormal drinking behavior (HP:0030082)1.97429473
101Polydipsia (HP:0001959)1.97429473
102Anxiety (HP:0000739)1.96596226
103Decreased central vision (HP:0007663)1.96575481
104Degeneration of the lateral corticospinal tracts (HP:0002314)1.96359069
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96359069
106Progressive inability to walk (HP:0002505)1.95740769
107Pendular nystagmus (HP:0012043)1.94893581
108Methylmalonic acidemia (HP:0002912)1.92443909
109Methylmalonic aciduria (HP:0012120)1.91721146
110Male pseudohermaphroditism (HP:0000037)1.91511872
111Truncal ataxia (HP:0002078)1.90518257
112Polyphagia (HP:0002591)1.90239092
113Protruding tongue (HP:0010808)1.90008059
114Specific learning disability (HP:0001328)1.89600746
115Aplasia/hypoplasia of the uterus (HP:0008684)1.88582327
116Esotropia (HP:0000565)1.87243447
117Increased intramyocellular lipid droplets (HP:0012240)1.86678293
118Hyperglycinemia (HP:0002154)1.86174487
119Parakeratosis (HP:0001036)1.86162898
120Abnormal rod and cone electroretinograms (HP:0008323)1.86126092
121Abnormality of binocular vision (HP:0011514)1.84612746
122Diplopia (HP:0000651)1.84612746
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83339251
124Increased corneal curvature (HP:0100692)1.82992678
125Keratoconus (HP:0000563)1.82992678
126Neurofibrillary tangles (HP:0002185)1.81876798
127Type 2 muscle fiber atrophy (HP:0003554)1.81805398
128Inability to walk (HP:0002540)1.81781282
129Occipital encephalocele (HP:0002085)1.80945111
130Blue irides (HP:0000635)1.79394946
131Cerebellar dysplasia (HP:0007033)1.79386161
132Concave nail (HP:0001598)1.78160114
133Sensory axonal neuropathy (HP:0003390)1.77369922
134Optic nerve hypoplasia (HP:0000609)1.77312125
135Preaxial hand polydactyly (HP:0001177)1.76703916
136Supranuclear gaze palsy (HP:0000605)1.76643485
137Rhinitis (HP:0012384)1.76512941
138Delusions (HP:0000746)1.75984252
139Absent speech (HP:0001344)1.75275401
140Tubulointerstitial nephritis (HP:0001970)1.73109472
141Amblyopia (HP:0000646)1.71533861
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71331106
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71331106
144Furrowed tongue (HP:0000221)1.70986298
145Large for gestational age (HP:0001520)1.70877865
146Type I transferrin isoform profile (HP:0003642)1.70626519
147Abnormal pupillary function (HP:0007686)1.70098412
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70006821
149Delayed CNS myelination (HP:0002188)1.69287063
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.68954244
151Epileptiform EEG discharges (HP:0011182)1.66237419
152Hemiparesis (HP:0001269)1.66027610
153Poor eye contact (HP:0000817)1.63426131
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.63306889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.22717235
2FRK3.62038861
3MAP3K123.54669038
4MAP4K23.53346344
5MAP2K72.98859377
6NTRK32.74473200
7TNIK2.67612707
8NUAK12.54938413
9EPHA42.38374599
10PRPF4B2.37031323
11MAP3K42.25720150
12PLK22.15755102
13STK162.12927135
14OXSR11.94349830
15BMPR1B1.82107578
16TRIM281.78763716
17CDK191.78568745
18BCR1.73448122
19AKT31.72895682
20RIPK41.66247634
21MAPK131.65073147
22TAOK31.60278728
23MST41.58327769
24SIK31.55402641
25ACVR1B1.49712706
26BMPR21.49148356
27NME11.49136769
28MUSK1.48332716
29STK391.45604723
30BCKDK1.40914398
31CCNB11.39874171
32PNCK1.39740315
33ARAF1.36252334
34ADRBK21.28866194
35SRPK11.27147682
36MARK11.27000292
37MYLK1.25991240
38MINK11.23116496
39TLK11.22900451
40GRK51.21973350
41PAK31.19932132
42CSNK1G11.17727781
43CAMKK21.17657320
44NEK61.15282339
45DAPK11.14698863
46CAMK2B1.13262298
47ZAK1.11458369
48CSNK1A1L1.10348998
49MAP2K41.09944272
50CAMK2A1.07640146
51MAPKAPK51.07268683
52INSRR1.07188963
53EPHA31.03190743
54YES11.02244485
55DYRK31.01861791
56PRKCE0.99486884
57ERBB30.96332760
58SGK2230.96030068
59SGK4940.96030068
60FES0.93109013
61FGFR20.92117527
62VRK20.90053191
63PRKCG0.89970152
64NTRK20.89202917
65GRK70.88493665
66UHMK10.86778204
67TSSK60.83685985
68VRK10.83266650
69BRAF0.83192210
70CDK50.81856072
71CDK30.81542210
72CAMK2D0.80073535
73CDK80.78113378
74FGR0.76568432
75TGFBR10.75114089
76DAPK20.73539774
77BRSK20.72900164
78EIF2AK30.72220139
79MAPK150.70205702
80SGK20.70064370
81PKN10.68708148
82PLK40.68090221
83IRAK20.67909339
84PTK2B0.66222252
85WNK30.66195676
86PBK0.65802449
87PHKG20.65799973
88PHKG10.65799973
89STK38L0.65581380
90TXK0.65008354
91DYRK1A0.64530020
92RPS6KA40.64004937
93FLT30.63374306
94PDK20.62759610
95TIE10.62174681
96DYRK20.62130264
97CSNK1G30.62085664
98IRAK40.61586426
99CAMK2G0.58972364
100PLK30.58379955
101ADRBK10.58333189
102RPS6KA50.56019348
103CDK180.54694927
104GRK10.54374980
105WNK40.53046006
106CDK140.51863300
107CSNK1G20.49596565
108OBSCN0.49589536
109CSNK1A10.48607464
110PRKACA0.47704084
111LIMK10.47691608
112NTRK10.46761079
113MKNK20.46514495
114CDK150.46388062
115KIT0.46105532
116PRKCH0.46050606
117ROCK20.45278440
118MAP3K90.44885839
119WEE10.44820681
120TNK20.44169213
121MKNK10.43761803
122SIK20.41511336
123CAMK10.40845534
124PINK10.38659984
125NEK10.37805020
126CDK11A0.37391536
127PRKCQ0.36772649
128IRAK10.36254805
129PRKG10.35386841
130PIK3CA0.35284921
131CSNK1D0.35128316
132MAP2K60.34964288
133ATR0.34934744
134PRKCA0.34446865
135PRKACB0.33657172
136PAK60.33351569
137SGK10.32361724
138PDK30.30820775
139PDK40.30820775
140TEC0.30721899
141EPHB20.29254906
142PLK10.29135746

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.32048566
2Nicotine addiction_Homo sapiens_hsa050333.80061138
3Collecting duct acid secretion_Homo sapiens_hsa049663.65724236
4Parkinsons disease_Homo sapiens_hsa050123.30112810
5Synaptic vesicle cycle_Homo sapiens_hsa047213.16134615
6Alzheimers disease_Homo sapiens_hsa050102.72325282
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50148152
8Protein export_Homo sapiens_hsa030602.46860750
9Vibrio cholerae infection_Homo sapiens_hsa051102.44005595
10Huntingtons disease_Homo sapiens_hsa050162.34029540
11GABAergic synapse_Homo sapiens_hsa047272.21746078
12Butanoate metabolism_Homo sapiens_hsa006502.19315423
13Morphine addiction_Homo sapiens_hsa050322.15383813
14Homologous recombination_Homo sapiens_hsa034402.00678941
15Serotonergic synapse_Homo sapiens_hsa047261.97477805
16Phototransduction_Homo sapiens_hsa047441.93113263
17Nitrogen metabolism_Homo sapiens_hsa009101.91911747
18Glutamatergic synapse_Homo sapiens_hsa047241.88170758
19Circadian entrainment_Homo sapiens_hsa047131.84743842
20Amphetamine addiction_Homo sapiens_hsa050311.83122899
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82604264
22Fanconi anemia pathway_Homo sapiens_hsa034601.81817364
23Proteasome_Homo sapiens_hsa030501.80881209
24Taste transduction_Homo sapiens_hsa047421.80779932
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77907074
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.74786343
27Olfactory transduction_Homo sapiens_hsa047401.74450481
28Propanoate metabolism_Homo sapiens_hsa006401.74446469
29Rheumatoid arthritis_Homo sapiens_hsa053231.73296559
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67202789
31Linoleic acid metabolism_Homo sapiens_hsa005911.66923999
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63052951
33Long-term potentiation_Homo sapiens_hsa047201.59949323
34Peroxisome_Homo sapiens_hsa041461.59216127
35RNA degradation_Homo sapiens_hsa030181.59064325
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57595837
37Dopaminergic synapse_Homo sapiens_hsa047281.54425412
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52947474
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51029954
40Cardiac muscle contraction_Homo sapiens_hsa042601.46730035
41Cocaine addiction_Homo sapiens_hsa050301.29024775
42Fatty acid elongation_Homo sapiens_hsa000621.27964295
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.27111239
44Long-term depression_Homo sapiens_hsa047301.26549909
45Non-homologous end-joining_Homo sapiens_hsa034501.23233297
46Salivary secretion_Homo sapiens_hsa049701.22662363
47Caffeine metabolism_Homo sapiens_hsa002321.22566016
48Phagosome_Homo sapiens_hsa041451.19508861
49Selenocompound metabolism_Homo sapiens_hsa004501.19314164
50Calcium signaling pathway_Homo sapiens_hsa040201.15427717
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.11656365
52Renin secretion_Homo sapiens_hsa049241.11193551
53Insulin secretion_Homo sapiens_hsa049111.10271813
54Tryptophan metabolism_Homo sapiens_hsa003801.09060222
55Cholinergic synapse_Homo sapiens_hsa047251.07153661
56Ether lipid metabolism_Homo sapiens_hsa005651.06125699
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04229558
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01760524
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00242799
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99512647
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97263640
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92860139
63Type I diabetes mellitus_Homo sapiens_hsa049400.90855758
64Vitamin B6 metabolism_Homo sapiens_hsa007500.85837920
65Gastric acid secretion_Homo sapiens_hsa049710.85659564
66Chemical carcinogenesis_Homo sapiens_hsa052040.82757818
67beta-Alanine metabolism_Homo sapiens_hsa004100.82340089
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.80723575
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80009388
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79962083
71Sphingolipid metabolism_Homo sapiens_hsa006000.79716315
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76682207
73Sulfur metabolism_Homo sapiens_hsa009200.76054346
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75758784
75RNA polymerase_Homo sapiens_hsa030200.74320389
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73234361
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70843373
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69878926
79Oxytocin signaling pathway_Homo sapiens_hsa049210.68373780
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67918990
81Nucleotide excision repair_Homo sapiens_hsa034200.67421283
82Retinol metabolism_Homo sapiens_hsa008300.66472703
83Autoimmune thyroid disease_Homo sapiens_hsa053200.65330679
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65016722
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.64668126
86Base excision repair_Homo sapiens_hsa034100.63758275
87RNA transport_Homo sapiens_hsa030130.61193955
88Pyrimidine metabolism_Homo sapiens_hsa002400.60750086
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59800248
90Spliceosome_Homo sapiens_hsa030400.58664553
91One carbon pool by folate_Homo sapiens_hsa006700.58484441
92Alcoholism_Homo sapiens_hsa050340.58448050
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57406556
94Axon guidance_Homo sapiens_hsa043600.55638839
95Mismatch repair_Homo sapiens_hsa034300.55207322
96African trypanosomiasis_Homo sapiens_hsa051430.55162583
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.55018087
98Gap junction_Homo sapiens_hsa045400.53875807
99cAMP signaling pathway_Homo sapiens_hsa040240.53459735
100Purine metabolism_Homo sapiens_hsa002300.52508472
101Basal transcription factors_Homo sapiens_hsa030220.51914496
102Hedgehog signaling pathway_Homo sapiens_hsa043400.51913096
103GnRH signaling pathway_Homo sapiens_hsa049120.51606184
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51531759
105Arachidonic acid metabolism_Homo sapiens_hsa005900.51378023
106Regulation of autophagy_Homo sapiens_hsa041400.51121396
107Asthma_Homo sapiens_hsa053100.47005542
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46378405
109ABC transporters_Homo sapiens_hsa020100.43133947
110Allograft rejection_Homo sapiens_hsa053300.42864676
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.42008816
112Glycerolipid metabolism_Homo sapiens_hsa005610.41984670
113Metabolic pathways_Homo sapiens_hsa011000.41085075
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39555033
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39545319
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38316304
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37620405
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37574080
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37540999
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36995222
121Ras signaling pathway_Homo sapiens_hsa040140.36443105
122Fatty acid metabolism_Homo sapiens_hsa012120.34276768
123Ribosome_Homo sapiens_hsa030100.32298321
124Primary immunodeficiency_Homo sapiens_hsa053400.31820255
125Melanogenesis_Homo sapiens_hsa049160.28332686
126Pyruvate metabolism_Homo sapiens_hsa006200.28133039
127Pancreatic secretion_Homo sapiens_hsa049720.26990686
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25954886
129Ovarian steroidogenesis_Homo sapiens_hsa049130.25783131
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23882850
131Steroid biosynthesis_Homo sapiens_hsa001000.23880499
132Tyrosine metabolism_Homo sapiens_hsa003500.22176556
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21526652
134Circadian rhythm_Homo sapiens_hsa047100.20573662
135MAPK signaling pathway_Homo sapiens_hsa040100.19912735
136Lysosome_Homo sapiens_hsa041420.17046566
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16823740
138N-Glycan biosynthesis_Homo sapiens_hsa005100.16597137
139Thyroid hormone synthesis_Homo sapiens_hsa049180.12569376
140Oocyte meiosis_Homo sapiens_hsa041140.12048756
141Inositol phosphate metabolism_Homo sapiens_hsa005620.11523949
142ErbB signaling pathway_Homo sapiens_hsa040120.11041990
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10900024
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10864547
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09933077

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