CRYZP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-lysine dimethylation (GO:0018027)5.49818529
2protein K6-linked ubiquitination (GO:0085020)5.24592276
3L-methionine biosynthetic process from methylthioadenosine (GO:0019509)5.21379798
4spliceosomal tri-snRNP complex assembly (GO:0000244)5.10927078
5nuclear pore complex assembly (GO:0051292)4.86856596
6Rap protein signal transduction (GO:0032486)4.72383899
7regulation of RNA export from nucleus (GO:0046831)4.67224612
8negative regulation of dendrite morphogenesis (GO:0050774)4.62776321
9cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.58677495
10histone H3-K9 methylation (GO:0051567)4.48440820
11dermatan sulfate metabolic process (GO:0030205)4.45593169
12negative regulation of mRNA processing (GO:0050686)4.32976776
13aggressive behavior (GO:0002118)4.28247835
14histone H2A acetylation (GO:0043968)4.19074544
15L-methionine salvage (GO:0071267)4.18869025
16L-methionine biosynthetic process (GO:0071265)4.18869025
17amino acid salvage (GO:0043102)4.18869025
18definitive hemopoiesis (GO:0060216)4.11230777
19somatic hypermutation of immunoglobulin genes (GO:0016446)4.06591441
20somatic diversification of immune receptors via somatic mutation (GO:0002566)4.06591441
21pore complex assembly (GO:0046931)4.05764474
22activation of Rac GTPase activity (GO:0032863)4.01602078
23response to follicle-stimulating hormone (GO:0032354)3.94340558
24nuclear pore organization (GO:0006999)3.93606369
25nucleotide-excision repair, DNA gap filling (GO:0006297)3.92823583
26regulation of translation in response to stress (GO:0043555)3.90849000
27glycine metabolic process (GO:0006544)3.90746171
28mitochondrial DNA replication (GO:0006264)3.71496666
29ER overload response (GO:0006983)3.70770904
30generation of neurons (GO:0048699)3.69326931
31isoprenoid biosynthetic process (GO:0008299)3.58720938
32B cell receptor signaling pathway (GO:0050853)3.55510327
33negative regulation of mRNA metabolic process (GO:1903312)3.54775142
34histone H3-K9 modification (GO:0061647)3.52714742
35double-strand break repair via nonhomologous end joining (GO:0006303)3.51000124
36non-recombinational repair (GO:0000726)3.51000124
37regulation of nucleobase-containing compound transport (GO:0032239)3.50509938
38rRNA catabolic process (GO:0016075)3.47734433
39methionine biosynthetic process (GO:0009086)3.40444429
40telomere maintenance via semi-conservative replication (GO:0032201)3.32946772
41telomere maintenance via recombination (GO:0000722)3.30669771
42L-serine metabolic process (GO:0006563)3.29772047
43positive regulation of B cell differentiation (GO:0045579)3.29690035
44sulfur amino acid biosynthetic process (GO:0000097)3.25706827
45regulation of histone H3-K27 methylation (GO:0061085)3.25121914
46poly(A)+ mRNA export from nucleus (GO:0016973)3.24786476
47megakaryocyte development (GO:0035855)3.24588731
48cholesterol biosynthetic process (GO:0006695)3.16796154
49purine nucleobase biosynthetic process (GO:0009113)3.14598955
50alternative mRNA splicing, via spliceosome (GO:0000380)3.14364666
51mitotic chromosome condensation (GO:0007076)3.13927722
52methionine metabolic process (GO:0006555)3.12327665
53phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.09044248
54peptidyl-lysine methylation (GO:0018022)3.07173683
55protein K11-linked deubiquitination (GO:0035871)3.05733370
56DNA synthesis involved in DNA repair (GO:0000731)3.02585827
57translesion synthesis (GO:0019985)3.01612034
58dosage compensation (GO:0007549)2.98084533
59regulation of mitotic spindle organization (GO:0060236)2.96157131
60mitochondrial DNA metabolic process (GO:0032042)2.95167587
61histone H4-K8 acetylation (GO:0043982)2.94615507
62histone H4-K5 acetylation (GO:0043981)2.94615507
63neurogenesis (GO:0022008)2.93888059
64mitotic sister chromatid cohesion (GO:0007064)2.91921707
65glomerular visceral epithelial cell development (GO:0072015)2.90017728
66negative regulation of necroptotic process (GO:0060546)2.89500190
67cellular response to gamma radiation (GO:0071480)2.88596641
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87675052
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87675052
70positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.85737769
71positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.83793341
72mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.83793341
73aspartate family amino acid biosynthetic process (GO:0009067)2.82691836
74Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80838331
75positive regulation of granulocyte differentiation (GO:0030854)2.78999115
76mitotic recombination (GO:0006312)2.77402340
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76261988
78mRNA splice site selection (GO:0006376)2.75608165
79microtubule severing (GO:0051013)2.75367543
80histone lysine methylation (GO:0034968)2.75116179
81histone H3-K4 trimethylation (GO:0080182)2.72279289
82regulation of granulocyte differentiation (GO:0030852)2.71279669
83response to lipoprotein particle (GO:0055094)2.70098449
84embryonic process involved in female pregnancy (GO:0060136)2.65778753
85positive regulation of macrophage differentiation (GO:0045651)2.64741910
86regulation of histone H3-K9 methylation (GO:0051570)2.63785815
87regulation of sister chromatid cohesion (GO:0007063)2.63358644
88DNA biosynthetic process (GO:0071897)2.62497235
89gastrulation with mouth forming second (GO:0001702)2.61981638
90dermatan sulfate biosynthetic process (GO:0030208)2.61914203
91sterol biosynthetic process (GO:0016126)2.61911915
92regulation of interferon-beta biosynthetic process (GO:0045357)2.61899314
93DNA-dependent DNA replication (GO:0006261)2.58781831
94hepatocyte apoptotic process (GO:0097284)2.58041187
95serine family amino acid catabolic process (GO:0009071)2.56641129
96granulocyte differentiation (GO:0030851)2.55108640
97positive regulation of prostaglandin secretion (GO:0032308)2.53428163
98nucleobase biosynthetic process (GO:0046112)2.51397450
99DNA methylation (GO:0006306)2.50820996
100DNA alkylation (GO:0006305)2.50820996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.42066130
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.81661102
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.97682651
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59599852
5MYC_22102868_ChIP-Seq_BL_Human3.54282687
6SCL_19346495_ChIP-Seq_HPC-7_Human3.34201895
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.75881557
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73336639
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.67079890
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50194759
11AR_21909140_ChIP-Seq_LNCAP_Human2.45915662
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.37904147
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35173759
14ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.31721695
15PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.22461863
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17622670
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.16528026
18ELK1_19687146_ChIP-ChIP_HELA_Human2.15302487
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13491477
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11182482
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08749880
22KDM5A_27292631_Chip-Seq_BREAST_Human2.02277945
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.01473451
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97946720
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97275745
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97126434
27CIITA_25753668_ChIP-Seq_RAJI_Human1.94078165
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.85023406
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84791315
30ERG_20887958_ChIP-Seq_HPC-7_Mouse1.84440334
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83282125
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.83277793
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74540133
34FOXP3_21729870_ChIP-Seq_TREG_Human1.72363714
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71840084
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67487815
37VDR_23849224_ChIP-Seq_CD4+_Human1.62985192
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62565773
39MYB_26560356_Chip-Seq_TH2_Human1.60524581
40TAF15_26573619_Chip-Seq_HEK293_Human1.58073376
41TFEB_21752829_ChIP-Seq_HELA_Human1.54480809
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53110625
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.50680097
44E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.46481006
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45371325
46MYB_26560356_Chip-Seq_TH1_Human1.44473351
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41764415
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41354054
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40652463
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.37864518
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37452131
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36486331
53GABP_19822575_ChIP-Seq_HepG2_Human1.34657961
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.34126069
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33100982
56CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28043995
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24565197
58CHD1_26751641_Chip-Seq_LNCaP_Human1.24480295
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23868686
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22583093
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22358397
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21375933
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15052717
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13084188
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11913983
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11477592
67FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09105896
68SPI1_23547873_ChIP-Seq_NB4_Human1.08801739
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07908785
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06728417
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06237056
72FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05621908
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04903510
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03065247
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03000334
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.01747319
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01394009
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01101743
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01051964
80MAF_26560356_Chip-Seq_TH1_Human1.00312524
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98772128
82GATA2_19941826_ChIP-Seq_K562_Human0.98064540
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97459825
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95553948
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95553948
86XRN2_22483619_ChIP-Seq_HELA_Human0.94676778
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92847224
88GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90869519
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90728206
90TCF7_22412390_ChIP-Seq_EML_Mouse0.89860137
91GATA1_19941826_ChIP-Seq_K562_Human0.88715347
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88667776
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86808207
94MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85997180
95RUNX1_22412390_ChIP-Seq_EML_Mouse0.85514125
96MAF_26560356_Chip-Seq_TH2_Human0.85132833
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85113885
98IRF8_21731497_ChIP-ChIP_J774_Mouse0.84690460
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84390475
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83977517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.33118938
2MP0008057_abnormal_DNA_replication4.32643273
3MP0003705_abnormal_hypodermis_morpholog3.93567876
4MP0010094_abnormal_chromosome_stability3.42588161
5MP0002009_preneoplasia3.31348454
6MP0003172_abnormal_lysosome_physiology3.07791364
7MP0003121_genomic_imprinting2.74137699
8MP0005451_abnormal_body_composition2.60731300
9MP0006138_congestive_heart_failure2.59005575
10MP0008058_abnormal_DNA_repair2.56904006
11MP0009384_cardiac_valve_regurgitation2.56411670
12MP0008438_abnormal_cutaneous_collagen2.31505559
13MP0003111_abnormal_nucleus_morphology2.25665893
14MP0003077_abnormal_cell_cycle2.11753907
15MP0005275_abnormal_skin_tensile2.11387534
16MP0003191_abnormal_cellular_cholesterol1.84540258
17MP0004808_abnormal_hematopoietic_stem1.78429696
18MP0003221_abnormal_cardiomyocyte_apopto1.76548913
19MP0000569_abnormal_digit_pigmentation1.68609244
20MP0001800_abnormal_humoral_immune1.65821699
21MP0002234_abnormal_pharynx_morphology1.59011687
22MP0009703_decreased_birth_body1.55079453
23MP0005058_abnormal_lysosome_morphology1.54681768
24MP0001270_distended_abdomen1.47738724
25MP0002092_abnormal_eye_morphology1.45062512
26MP0002877_abnormal_melanocyte_morpholog1.44587486
27MP0002398_abnormal_bone_marrow1.37373179
28MP0003763_abnormal_thymus_physiology1.36037649
29MP0004233_abnormal_muscle_weight1.35428270
30MP0009697_abnormal_copulation1.34985667
31MP0001764_abnormal_homeostasis1.34322860
32MP0001730_embryonic_growth_arrest1.34274222
33MP0000465_gastrointestinal_hemorrhage1.33407497
34MP0002166_altered_tumor_susceptibility1.32904620
35MP0005670_abnormal_white_adipose1.30562076
36MP0004084_abnormal_cardiac_muscle1.30472331
37MP0000015_abnormal_ear_pigmentation1.28355939
38MP0000689_abnormal_spleen_morphology1.27989163
39MP0005171_absent_coat_pigmentation1.22813842
40MP0008007_abnormal_cellular_replicative1.20875721
41MP0004957_abnormal_blastocyst_morpholog1.18533521
42MP0008961_abnormal_basal_metabolism1.16537865
43MP0002396_abnormal_hematopoietic_system1.14158237
44MP0008932_abnormal_embryonic_tissue1.13989345
45MP0003300_gastrointestinal_ulcer1.12669929
46MP0002452_abnormal_antigen_presenting1.09945612
47MP0002019_abnormal_tumor_incidence1.09776264
48MP0006035_abnormal_mitochondrial_morpho1.08234529
49MP0004264_abnormal_extraembryonic_tissu1.05213832
50MP0005174_abnormal_tail_pigmentation1.03143080
51MP0002177_abnormal_outer_ear1.01148502
52MP0003984_embryonic_growth_retardation0.97706651
53MP0004858_abnormal_nervous_system0.96892897
54MP0001849_ear_inflammation0.96604968
55MP0004133_heterotaxia0.95963104
56MP0002088_abnormal_embryonic_growth/wei0.95494382
57MP0005391_vision/eye_phenotype0.94192085
58MP0005380_embryogenesis_phenotype0.94061081
59MP0001672_abnormal_embryogenesis/_devel0.94061081
60MP0002420_abnormal_adaptive_immunity0.93564649
61MP0001286_abnormal_eye_development0.93041128
62MP0003385_abnormal_body_wall0.92397247
63MP0001819_abnormal_immune_cell0.90034858
64MP0008260_abnormal_autophagy0.88140142
65MP0001545_abnormal_hematopoietic_system0.87557401
66MP0005397_hematopoietic_system_phenotyp0.87557401
67MP0002722_abnormal_immune_system0.87106792
68MP0005621_abnormal_cell_physiology0.86128918
69MP0005387_immune_system_phenotype0.85778624
70MP0001790_abnormal_immune_system0.85778624
71MP0010352_gastrointestinal_tract_polyps0.84353242
72MP0000613_abnormal_salivary_gland0.83438884
73MP0000733_abnormal_muscle_development0.83037915
74MP0005075_abnormal_melanosome_morpholog0.82221779
75MP0002429_abnormal_blood_cell0.82172552
76MP0008877_abnormal_DNA_methylation0.82059472
77MP0002080_prenatal_lethality0.82026045
78MP0001502_abnormal_circadian_rhythm0.80094199
79MP0000428_abnormal_craniofacial_morphol0.79945675
80MP0001661_extended_life_span0.79909864
81MP0002132_abnormal_respiratory_system0.78849803
82MP0000716_abnormal_immune_system0.78825844
83MP0002928_abnormal_bile_duct0.78650517
84MP0002086_abnormal_extraembryonic_tissu0.76853004
85MP0001851_eye_inflammation0.76836611
86MP0008770_decreased_survivor_rate0.76659309
87MP0000703_abnormal_thymus_morphology0.75889216
88MP0005384_cellular_phenotype0.75868682
89MP0001299_abnormal_eye_distance/0.75379576
90MP0001293_anophthalmia0.74787351
91MP0002084_abnormal_developmental_patter0.74271274
92MP0002723_abnormal_immune_serum0.72300195
93MP0001697_abnormal_embryo_size0.71451673
94MP0001929_abnormal_gametogenesis0.70980859
95MP0002233_abnormal_nose_morphology0.69601068
96MP0002697_abnormal_eye_size0.69475789
97MP0005385_cardiovascular_system_phenoty0.68870707
98MP0001544_abnormal_cardiovascular_syste0.68870707
99MP0002282_abnormal_trachea_morphology0.68850752
100MP0005076_abnormal_cell_differentiation0.67957005

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.82201301
2Hypoplastic pelvis (HP:0008839)4.28235773
3Cellulitis (HP:0100658)3.95752005
4Breast hypoplasia (HP:0003187)3.57895502
5Prominent nose (HP:0000448)3.51250267
6Abnormality of the fingertips (HP:0001211)3.48204536
7J-shaped sella turcica (HP:0002680)3.39207898
8Broad face (HP:0000283)3.32982939
9Spastic diplegia (HP:0001264)3.28088457
10Increased serum pyruvate (HP:0003542)3.26692126
11Aplastic anemia (HP:0001915)3.21754050
12Patent foramen ovale (HP:0001655)3.13260299
13Cervical subluxation (HP:0003308)3.05131580
14Hyperglycinemia (HP:0002154)3.03157668
15Scanning speech (HP:0002168)2.98716905
16Asplenia (HP:0001746)2.94726695
1711 pairs of ribs (HP:0000878)2.93966671
18Medulloblastoma (HP:0002885)2.85092913
19Panhypogammaglobulinemia (HP:0003139)2.80084469
20Deformed sella turcica (HP:0002681)2.76906275
21Ependymoma (HP:0002888)2.76747115
22B lymphocytopenia (HP:0010976)2.73360417
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.65125914
24Abnormality of B cell number (HP:0010975)2.63333111
25Abnormality of glycolysis (HP:0004366)2.62875906
26Osteomyelitis (HP:0002754)2.62268525
27Lymphoma (HP:0002665)2.60917897
28Hip dysplasia (HP:0001385)2.59854232
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59161912
30Viral hepatitis (HP:0006562)2.57796704
31Poor speech (HP:0002465)2.56801261
32Biconcave vertebral bodies (HP:0004586)2.56575161
33Anhidrosis (HP:0000970)2.55319271
34Severe combined immunodeficiency (HP:0004430)2.50283496
35Pointed chin (HP:0000307)2.42702720
36Subacute progressive viral hepatitis (HP:0006572)2.42044114
37Recurrent bronchitis (HP:0002837)2.41801599
38Verrucae (HP:0200043)2.41186825
39Papilloma (HP:0012740)2.41186825
40Neonatal hypoglycemia (HP:0001998)2.39242966
41Recurrent pneumonia (HP:0006532)2.35484708
42Premature ovarian failure (HP:0008209)2.32856663
43Recurrent viral infections (HP:0004429)2.28523830
44Abnormality of the musculature of the hand (HP:0001421)2.26286936
45Stomach cancer (HP:0012126)2.23471378
46Missing ribs (HP:0000921)2.15853369
47Astrocytoma (HP:0009592)2.15394268
48Abnormality of the astrocytes (HP:0100707)2.15394268
49Spondylolisthesis (HP:0003302)2.11764388
50Hemorrhage of the eye (HP:0011885)2.10487728
51Freckling (HP:0001480)2.09936255
52Micronodular cirrhosis (HP:0001413)2.09407197
53Combined immunodeficiency (HP:0005387)2.07071337
54Rhabdomyosarcoma (HP:0002859)2.06596958
55Tubulointerstitial nephritis (HP:0001970)2.05570749
56Recurrent fungal infections (HP:0002841)2.04759761
57Sepsis (HP:0100806)2.04062516
58Hypoplasia of the thymus (HP:0000778)2.03053478
59Capillary hemangiomas (HP:0005306)2.03029556
60Autoamputation (HP:0001218)2.01710387
61Abnormality of the peritoneum (HP:0002585)2.00529393
62Short chin (HP:0000331)1.99797852
63Recurrent sinusitis (HP:0011108)1.98543977
64Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.97387472
65Sandal gap (HP:0001852)1.97320702
66Eczematoid dermatitis (HP:0000976)1.97282040
67Glioma (HP:0009733)1.97111586
68Supernumerary spleens (HP:0009799)1.96861535
69Long foot (HP:0001833)1.95938833
70Spinal canal stenosis (HP:0003416)1.94275925
71Cerebral palsy (HP:0100021)1.93191001
72Progressive external ophthalmoplegia (HP:0000590)1.90534454
73Abnormality of oral frenula (HP:0000190)1.87821917
74Sparse lateral eyebrow (HP:0005338)1.86894812
75Fibular hypoplasia (HP:0003038)1.86248943
76Colitis (HP:0002583)1.85577438
77Bronchitis (HP:0012387)1.84768643
78Widely spaced teeth (HP:0000687)1.82170755
79Impulsivity (HP:0100710)1.81082612
80Hypoplasia of the odontoid process (HP:0003311)1.80917643
81Cerebral hypomyelination (HP:0006808)1.79913693
82Meningitis (HP:0001287)1.79269373
83Truncus arteriosus (HP:0001660)1.78478978
84Small hand (HP:0200055)1.78279222
85Attenuation of retinal blood vessels (HP:0007843)1.77883563
86Acute lymphatic leukemia (HP:0006721)1.76845256
87Secondary amenorrhea (HP:0000869)1.76664134
88Gastrointestinal stroma tumor (HP:0100723)1.76638662
89Hypoplastic female external genitalia (HP:0012815)1.76233865
90Renal cortical cysts (HP:0000803)1.75351989
91Short humerus (HP:0005792)1.75043169
92Dysostosis multiplex (HP:0000943)1.73477721
93Delayed gross motor development (HP:0002194)1.72470225
94Tubular atrophy (HP:0000092)1.71556474
95Basal cell carcinoma (HP:0002671)1.68351077
96Bowel incontinence (HP:0002607)1.68005380
97Atonic seizures (HP:0010819)1.67636238
98Alopecia of scalp (HP:0002293)1.67202673
99Agnosia (HP:0010524)1.66587474
100Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65034537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD44.62613650
2CDK123.68069521
3EIF2AK13.53327989
4CDC73.46536546
5EIF2AK33.15087493
6BMPR22.96201910
7MST42.81709221
8EPHB12.52349067
9WNK32.21720163
10ERN12.11334889
11ZAK1.95838141
12IRAK41.93905036
13GRK61.85971292
14BMPR1B1.85141021
15CSNK1G11.62652621
16STK101.59654619
17MAPK111.54690981
18DYRK31.54199229
19BCR1.53425494
20SRPK11.43316978
21AKT31.42941993
22BTK1.39195247
23BRSK21.36374109
24FLT31.34432681
25ATR1.32713604
26NEK91.28642225
27RPS6KA41.23955326
28CSNK1A1L1.23869927
29PKN21.23661434
30LATS11.17904520
31CSNK1G31.12766326
32NEK11.10517192
33AKT21.08217667
34MKNK21.08179186
35BLK1.05400999
36SCYL21.03116962
37TTK1.02300438
38CDK60.99954541
39TEC0.97704570
40ERBB40.97361309
41CLK10.95047309
42BCKDK0.86824628
43MET0.83704274
44SYK0.82991831
45EPHA30.82871456
46WEE10.80754686
47MAP3K140.80285402
48CDK80.79648623
49IKBKB0.78771597
50MAP3K120.78456072
51ACVR1B0.71670763
52ATM0.70935326
53MTOR0.70794942
54CSNK1G20.69883816
55PRKCE0.69754742
56PBK0.68969617
57TBK10.67120117
58NEK20.66167162
59LYN0.64880576
60PIM20.63916030
61PKN10.61463920
62LCK0.61359154
63CDK30.60966107
64RPS6KB20.60870225
65EEF2K0.60625238
66STK380.57443990
67PLK10.56787243
68YES10.55996839
69CDK40.51482159
70CHEK10.51343921
71MAP2K70.50516341
72MKNK10.50493377
73RPS6KA50.50343171
74MAP3K80.49742870
75CDK70.49654955
76MAP3K50.48554147
77CDK20.48481872
78EPHA20.48428369
79PDGFRA0.47517510
80CDK90.46454037
81PINK10.42774539
82CDK10.40383104
83CHEK20.39937351
84CHUK0.39585101
85PLK40.39454813
86AKT10.38915425
87ITK0.38141000
88FES0.36589541
89AURKB0.36245881
90PRKD20.35845512
91TSSK60.35476609
92MAP3K10.35253265
93MAP3K40.35160480
94PRKD10.33726816
95TRPM70.32688839
96CDK190.32582752
97MAPK10.31725151
98STK30.31630751
99MAPK130.31048026
100GSK3B0.30623593

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.48018275
2Non-homologous end-joining_Homo sapiens_hsa034504.25518493
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.48318699
4Mismatch repair_Homo sapiens_hsa034302.80186491
5Base excision repair_Homo sapiens_hsa034102.52761304
6DNA replication_Homo sapiens_hsa030302.47874823
7Lysine degradation_Homo sapiens_hsa003102.42729704
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28571654
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18322380
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.13375958
11Steroid biosynthesis_Homo sapiens_hsa001002.12485630
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05276356
13One carbon pool by folate_Homo sapiens_hsa006702.00386203
14B cell receptor signaling pathway_Homo sapiens_hsa046621.99315094
15Primary immunodeficiency_Homo sapiens_hsa053401.83953511
16Homologous recombination_Homo sapiens_hsa034401.76646736
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.75384005
18Nucleotide excision repair_Homo sapiens_hsa034201.72452151
19Butanoate metabolism_Homo sapiens_hsa006501.69210339
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62501642
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54298315
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.50371727
23mRNA surveillance pathway_Homo sapiens_hsa030151.43112520
24Fanconi anemia pathway_Homo sapiens_hsa034601.30276677
25Asthma_Homo sapiens_hsa053101.30110155
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21630164
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18948484
28RNA transport_Homo sapiens_hsa030131.17682421
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.13389175
30Pyrimidine metabolism_Homo sapiens_hsa002401.12695183
31Herpes simplex infection_Homo sapiens_hsa051681.11105719
32Cell cycle_Homo sapiens_hsa041101.10722561
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08086176
34Viral carcinogenesis_Homo sapiens_hsa052031.05984525
35Circadian rhythm_Homo sapiens_hsa047101.04700143
36RNA degradation_Homo sapiens_hsa030181.03829572
37Thyroid cancer_Homo sapiens_hsa052161.03593034
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02892743
39Systemic lupus erythematosus_Homo sapiens_hsa053221.02076228
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01001614
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.98391681
42Type I diabetes mellitus_Homo sapiens_hsa049400.93405370
43Propanoate metabolism_Homo sapiens_hsa006400.92830947
44Inositol phosphate metabolism_Homo sapiens_hsa005620.88074527
45Spliceosome_Homo sapiens_hsa030400.85149035
46Non-small cell lung cancer_Homo sapiens_hsa052230.85117912
47Allograft rejection_Homo sapiens_hsa053300.83960443
48Epstein-Barr virus infection_Homo sapiens_hsa051690.83150372
49Viral myocarditis_Homo sapiens_hsa054160.81852206
50HTLV-I infection_Homo sapiens_hsa051660.79110571
51Autoimmune thyroid disease_Homo sapiens_hsa053200.77385878
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.77200318
53Small cell lung cancer_Homo sapiens_hsa052220.75910221
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75510263
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.71497990
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69517846
57Chronic myeloid leukemia_Homo sapiens_hsa052200.69377250
58Choline metabolism in cancer_Homo sapiens_hsa052310.69162924
59Leishmaniasis_Homo sapiens_hsa051400.68070685
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67949105
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63964864
62N-Glycan biosynthesis_Homo sapiens_hsa005100.62042550
63Antigen processing and presentation_Homo sapiens_hsa046120.60686951
64Basal transcription factors_Homo sapiens_hsa030220.60329616
65Graft-versus-host disease_Homo sapiens_hsa053320.58623170
66Toxoplasmosis_Homo sapiens_hsa051450.57014017
67Measles_Homo sapiens_hsa051620.56418163
68Purine metabolism_Homo sapiens_hsa002300.54972367
69Biosynthesis of amino acids_Homo sapiens_hsa012300.54907526
70Acute myeloid leukemia_Homo sapiens_hsa052210.53782681
71Influenza A_Homo sapiens_hsa051640.50964590
72Alcoholism_Homo sapiens_hsa050340.50647135
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50603181
74Hepatitis B_Homo sapiens_hsa051610.49080307
75Prostate cancer_Homo sapiens_hsa052150.48621802
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.48328185
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48245638
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48092412
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45434609
80Hematopoietic cell lineage_Homo sapiens_hsa046400.45072889
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43902088
82Colorectal cancer_Homo sapiens_hsa052100.43641944
83AMPK signaling pathway_Homo sapiens_hsa041520.42852229
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.42796683
85Pancreatic cancer_Homo sapiens_hsa052120.39862300
86Hepatitis C_Homo sapiens_hsa051600.38968116
87mTOR signaling pathway_Homo sapiens_hsa041500.38791106
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.38688971
89Selenocompound metabolism_Homo sapiens_hsa004500.38415208
90RNA polymerase_Homo sapiens_hsa030200.38253758
91Carbon metabolism_Homo sapiens_hsa012000.37574794
92Adherens junction_Homo sapiens_hsa045200.36440591
93Apoptosis_Homo sapiens_hsa042100.35774758
94TNF signaling pathway_Homo sapiens_hsa046680.35713055
95Tuberculosis_Homo sapiens_hsa051520.35532927
96Olfactory transduction_Homo sapiens_hsa047400.35197499
97Phototransduction_Homo sapiens_hsa047440.34193044
98Insulin resistance_Homo sapiens_hsa049310.33868511
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33639159
100p53 signaling pathway_Homo sapiens_hsa041150.32498998

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