CS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)8.13483364
2sarcomere organization (GO:0045214)7.03787981
3regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.83646545
4carnitine shuttle (GO:0006853)6.62193239
5cardiac myofibril assembly (GO:0055003)6.59634492
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.43601439
7regulation of acyl-CoA biosynthetic process (GO:0050812)6.21043314
8NADH metabolic process (GO:0006734)6.00164521
9negative regulation of potassium ion transmembrane transport (GO:1901380)5.94026077
10regulation of cofactor metabolic process (GO:0051193)5.91491542
11regulation of coenzyme metabolic process (GO:0051196)5.91491542
12fatty acid transmembrane transport (GO:1902001)5.82761706
13actin-myosin filament sliding (GO:0033275)5.69098860
14muscle filament sliding (GO:0030049)5.69098860
15myofibril assembly (GO:0030239)5.64430338
16plasma membrane repair (GO:0001778)5.37134736
17cardiac muscle contraction (GO:0060048)5.34803016
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.30400733
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.04079605
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.99421143
21cardiac muscle cell development (GO:0055013)4.99407679
22carnitine transmembrane transport (GO:1902603)4.93092783
23regulation of sequestering of triglyceride (GO:0010889)4.89062335
24ventricular cardiac muscle cell action potential (GO:0086005)4.81488102
25nuclear pore complex assembly (GO:0051292)4.80895691
26COPI coating of Golgi vesicle (GO:0048205)4.68924122
27Golgi transport vesicle coating (GO:0048200)4.68924122
28actin-mediated cell contraction (GO:0070252)4.68415044
29cardiac cell development (GO:0055006)4.68358118
30regulation of sulfur metabolic process (GO:0042762)4.65925397
31mitotic chromosome condensation (GO:0007076)4.64170019
32actomyosin structure organization (GO:0031032)4.61008330
33bundle of His cell to Purkinje myocyte communication (GO:0086069)4.59237902
34carnitine transport (GO:0015879)4.58340193
35amino-acid betaine transport (GO:0015838)4.58340193
36DNA unwinding involved in DNA replication (GO:0006268)4.53521381
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.50534424
38regulation of actin filament-based movement (GO:1903115)4.48992339
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.48225437
40regulation of fatty acid oxidation (GO:0046320)4.45029814
41regulation of skeletal muscle contraction (GO:0014819)4.44722080
42regulation of translational fidelity (GO:0006450)4.43307309
43regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.40672510
44lysine metabolic process (GO:0006553)4.37041409
45lysine catabolic process (GO:0006554)4.37041409
462-oxoglutarate metabolic process (GO:0006103)4.28852289
47cell communication involved in cardiac conduction (GO:0086065)4.25605841
48striated muscle contraction (GO:0006941)4.21308784
49succinate metabolic process (GO:0006105)4.20952882
50tricarboxylic acid metabolic process (GO:0072350)4.18453962
51nuclear pore organization (GO:0006999)4.16238005
52cardiac muscle hypertrophy (GO:0003300)4.10994849
53oxidative phosphorylation (GO:0006119)4.10257449
54regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.06294145
55regulation of relaxation of muscle (GO:1901077)4.05890190
56cell communication by electrical coupling (GO:0010644)4.05418420
57cardiac muscle tissue morphogenesis (GO:0055008)4.00401996
58heart trabecula formation (GO:0060347)3.99649639
59fatty acid beta-oxidation (GO:0006635)3.96982368
60gluconeogenesis (GO:0006094)3.95661395
61oxaloacetate metabolic process (GO:0006107)3.94277302
62striated muscle hypertrophy (GO:0014897)3.90973613
63peptidyl-arginine omega-N-methylation (GO:0035247)3.87980954
64proline biosynthetic process (GO:0006561)3.83913716
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.83583561
66ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.77469373
67regulation of the force of heart contraction (GO:0002026)3.72997367
68aspartate family amino acid catabolic process (GO:0009068)3.72854650
69regulation of membrane repolarization (GO:0060306)3.72646924
70actin filament-based movement (GO:0030048)3.70797786
71adult heart development (GO:0007512)3.70745666
72hexose biosynthetic process (GO:0019319)3.68089680
73regulation of sarcomere organization (GO:0060297)3.64860903
74formation of translation preinitiation complex (GO:0001731)3.62264530
75glycolytic process (GO:0006096)3.60877353
76muscle tissue morphogenesis (GO:0060415)3.59922133
77mitotic sister chromatid segregation (GO:0000070)3.58813427
78sarcoplasmic reticulum calcium ion transport (GO:0070296)3.56830819
79monosaccharide biosynthetic process (GO:0046364)3.50627945
80regulation of cell communication by electrical coupling (GO:0010649)3.49246169
81regulation of striated muscle contraction (GO:0006942)3.47676391
82acetyl-CoA metabolic process (GO:0006084)3.40753481
83IMP metabolic process (GO:0046040)3.39941884
84positive regulation of fatty acid oxidation (GO:0046321)3.39341668
85cardiac muscle cell action potential involved in contraction (GO:0086002)3.39227993
86sister chromatid segregation (GO:0000819)3.35784385
87muscle hypertrophy (GO:0014896)3.35578059
88biotin metabolic process (GO:0006768)3.34648291
89ATP synthesis coupled proton transport (GO:0015986)3.33502299
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.33502299
91cardiac muscle cell action potential (GO:0086001)3.31430497
92peptidyl-arginine N-methylation (GO:0035246)3.31373010
93peptidyl-arginine methylation (GO:0018216)3.31373010
94pore complex assembly (GO:0046931)3.30627189
95lipid particle organization (GO:0034389)3.27534329
96retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.26947111
97heart process (GO:0003015)3.24077811
98heart contraction (GO:0060047)3.24077811
99regulation of cardioblast differentiation (GO:0051890)3.23317642
100creatine metabolic process (GO:0006600)3.21097947
101quaternary ammonium group transport (GO:0015697)3.21070620
102IMP biosynthetic process (GO:0006188)3.19749146
103ventricular cardiac muscle cell development (GO:0055015)3.19526757
104negative regulation of potassium ion transport (GO:0043267)3.19188681
105cardiac muscle adaptation (GO:0014887)3.18294902
106cardiac muscle hypertrophy in response to stress (GO:0014898)3.18294902
107muscle hypertrophy in response to stress (GO:0003299)3.18294902
108respiratory electron transport chain (GO:0022904)3.15691553
109intracellular lipid transport (GO:0032365)3.15093080
110fatty acid catabolic process (GO:0009062)3.14969340
111mitochondrial fusion (GO:0008053)3.13307910
112fatty acid oxidation (GO:0019395)3.12342571
113mitotic nuclear envelope disassembly (GO:0007077)3.12306699
114positive regulation of fatty acid beta-oxidation (GO:0032000)3.12176065
115negative regulation of cell size (GO:0045792)3.10807867
116DNA strand elongation involved in DNA replication (GO:0006271)3.10633869
117skeletal muscle contraction (GO:0003009)3.08493975
118regulation of cardiac muscle cell contraction (GO:0086004)3.07087167
119lipid oxidation (GO:0034440)3.06803221
120DNA strand elongation (GO:0022616)3.06351383
121electron transport chain (GO:0022900)3.05059281
122epithelial cell-cell adhesion (GO:0090136)3.03374917
123response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.03330625
124regulation of heart rate (GO:0002027)3.02982628
125cardiac conduction (GO:0061337)3.02217585
126regulation of fatty acid beta-oxidation (GO:0031998)3.00551856
127striated muscle cell development (GO:0055002)2.99082551
128regulation of RNA export from nucleus (GO:0046831)2.95360981
129nuclear envelope disassembly (GO:0051081)2.94833377
130membrane disassembly (GO:0030397)2.94833377
131chromosome condensation (GO:0030261)2.94216162
132histone arginine methylation (GO:0034969)2.93369280
133fatty acid homeostasis (GO:0055089)2.90594717
134protein complex localization (GO:0031503)2.89803385
135DNA replication initiation (GO:0006270)2.88519483
136regulation of mitotic spindle organization (GO:0060236)2.87065701
137spliceosomal tri-snRNP complex assembly (GO:0000244)2.85759324
138peptidyl-lysine dimethylation (GO:0018027)2.85637749
139pyruvate metabolic process (GO:0006090)2.84358957
140protein localization to chromosome, centromeric region (GO:0071459)2.80762894
141ribosome assembly (GO:0042255)2.72298168
142glucose 6-phosphate metabolic process (GO:0051156)2.71702969
143regulation of spindle organization (GO:0090224)2.68856259
144regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67792762
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66101836
146pentose-phosphate shunt (GO:0006098)2.65825989
147positive regulation of DNA-dependent DNA replication (GO:2000105)2.64997468
148cell-substrate adherens junction assembly (GO:0007045)2.64989230
149focal adhesion assembly (GO:0048041)2.64989230
150mRNA stabilization (GO:0048255)2.62574813
151RNA stabilization (GO:0043489)2.62574813
152mitotic sister chromatid cohesion (GO:0007064)2.61593274
153telomere maintenance via semi-conservative replication (GO:0032201)2.61036766
154cellular protein complex localization (GO:0034629)2.60617653
155nuclear envelope organization (GO:0006998)2.59397401
156folic acid-containing compound biosynthetic process (GO:0009396)2.58817828
157dicarboxylic acid biosynthetic process (GO:0043650)2.58703992
158tRNA aminoacylation for protein translation (GO:0006418)2.57550349
159glycogen catabolic process (GO:0005980)2.56798932
160negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.53697446
161regulation of nucleobase-containing compound transport (GO:0032239)2.52577872
162fructose metabolic process (GO:0006000)2.49176145
163DNA topological change (GO:0006265)2.48819705
164muscle cell cellular homeostasis (GO:0046716)2.48668881
165protein localization to microtubule (GO:0035372)2.46634175
166regulation of sister chromatid cohesion (GO:0007063)2.45352605
167tRNA aminoacylation (GO:0043039)2.44993281
168amino acid activation (GO:0043038)2.44993281
169NADPH regeneration (GO:0006740)2.44653082
170regulation of translational elongation (GO:0006448)2.44570737
171glucose metabolic process (GO:0006006)2.44191657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.70267192
2E2F7_22180533_ChIP-Seq_HELA_Human7.10193672
3* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.58116829
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.06836784
5ZNF263_19887448_ChIP-Seq_K562_Human3.63204602
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.34054225
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.31440098
8CLOCK_20551151_ChIP-Seq_293T_Human3.27201700
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88111515
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.85125312
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.74819886
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74266374
13TBX20_22328084_ChIP-Seq_HEART_Mouse2.73412799
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.73412799
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.72699549
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38909456
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32383396
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30752209
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28388833
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.26264440
21XRN2_22483619_ChIP-Seq_HELA_Human2.23434273
22* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23043861
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20560718
24ZFX_18555785_ChIP-Seq_MESCs_Mouse2.15642945
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06833678
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.06510155
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.05528867
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00513472
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00046348
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.98101679
31MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.95312282
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93926652
33* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92859520
34ATF3_27146783_Chip-Seq_COLON_Human1.87184788
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.87177461
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78154252
37GATA4_21415370_ChIP-Seq_HL-1_Mouse1.78131179
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78047226
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77882237
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75979035
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74175454
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71562409
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71302901
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70847084
45DCP1A_22483619_ChIP-Seq_HELA_Human1.66830663
46NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.62110716
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.59766655
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59362666
49KDM2B_26808549_Chip-Seq_DND41_Human1.59229868
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59141201
51RACK7_27058665_Chip-Seq_MCF-7_Human1.58875638
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58718122
53* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57141748
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.56657570
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55297570
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.54214251
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54123441
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.52939523
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50883405
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50791214
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.50612910
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49259652
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49196550
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.48164837
65KDM5A_27292631_Chip-Seq_BREAST_Human1.47438799
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.47129597
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44690426
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44245305
69LXR_22292898_ChIP-Seq_THP-1_Human1.42400559
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42170426
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40838103
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39909447
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39792024
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39524818
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38715558
76TTF2_22483619_ChIP-Seq_HELA_Human1.36215234
77GABP_19822575_ChIP-Seq_HepG2_Human1.33155070
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.30739793
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30197589
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30166113
81AR_21909140_ChIP-Seq_LNCAP_Human1.29813871
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29419969
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29252522
84MYC_22102868_ChIP-Seq_BL_Human1.28634476
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28440123
86CIITA_25753668_ChIP-Seq_RAJI_Human1.28087697
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27222406
88* CHD1_26751641_Chip-Seq_LNCaP_Human1.27194095
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26585110
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24616542
91P68_20966046_ChIP-Seq_HELA_Human1.21306753
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19815844
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19413834
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19230684
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19200465
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18434339
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17935040
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17918406
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17440371
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17005694
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15132296
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.14623399
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.14590760
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14477199
105* RUNX1_27514584_Chip-Seq_MCF-7_Human1.14154044
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13913357
107* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.13350532
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13347694
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12680980
110* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11236748
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10055799
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09920950
113LXR_22158963_ChIP-Seq_LIVER_Mouse1.08367529
114* RXR_22158963_ChIP-Seq_LIVER_Mouse1.08353048
115TP63_22573176_ChIP-Seq_HFKS_Human1.06606673
116YY1_21170310_ChIP-Seq_MESCs_Mouse1.06431769
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06179977
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06139386
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06041354
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05503413
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05140051
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04177353
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04133505
124CREB1_26743006_Chip-Seq_LNCaP_Human1.03560220
125KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02829774
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02583908
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01202944
128* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01136284
129* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00946981
130* NCOR1_26117541_ChIP-Seq_K562_Human1.00638309
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99761346
132KDM2B_26808549_Chip-Seq_K562_Human0.99464729
133* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99109447
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.96883219
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96373838
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.95040157
137* TFEB_21752829_ChIP-Seq_HELA_Human0.93848197
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93757288
139TP53_22127205_ChIP-Seq_IMR90_Human0.92963793
140TCF7_22412390_ChIP-Seq_EML_Mouse0.92891039
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92298803
142DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90808457
143TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90700315
144SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89970418
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89770034
146BCL6_27268052_Chip-Seq_Bcells_Human0.89408000
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88641191
148BCOR_27268052_Chip-Seq_Bcells_Human0.85269965
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85250682
150* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84715807
151TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84673614
152VDR_21846776_ChIP-Seq_THP-1_Human0.83877269
153SMC4_20622854_ChIP-Seq_HELA_Human0.82766552
154GATA6_25053715_ChIP-Seq_YYC3_Human0.82315737
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82240300
156GATA1_19941826_ChIP-Seq_K562_Human0.81891065
157KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80647706
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80250910
159SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80025208
160* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79894427
161ISL1_27105846_Chip-Seq_CPCs_Mouse0.79722830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.74815810
2MP0003646_muscle_fatigue5.08539580
3MP0004084_abnormal_cardiac_muscle4.88976474
4MP0000751_myopathy4.45847926
5MP0004215_abnormal_myocardial_fiber4.03308179
6MP0004036_abnormal_muscle_relaxation3.52221024
7MP0005330_cardiomyopathy3.42747944
8MP0004130_abnormal_muscle_cell3.42654312
9MP0000749_muscle_degeneration3.30060988
10MP0004087_abnormal_muscle_fiber3.05191780
11MP0002972_abnormal_cardiac_muscle2.77905985
12MP0008775_abnormal_heart_ventricle2.68933501
13MP0000750_abnormal_muscle_regeneration2.63283062
14MP0005666_abnormal_adipose_tissue2.57731777
15MP0005620_abnormal_muscle_contractility2.51637144
16MP0003111_abnormal_nucleus_morphology2.47061099
17MP0005385_cardiovascular_system_phenoty2.44386254
18MP0001544_abnormal_cardiovascular_syste2.44386254
19MP0005670_abnormal_white_adipose2.42737863
20MP0010630_abnormal_cardiac_muscle2.42073910
21MP0003705_abnormal_hypodermis_morpholog2.41196519
22MP0006138_congestive_heart_failure2.35587476
23MP0002106_abnormal_muscle_physiology2.31031967
24MP0002269_muscular_atrophy2.29627332
25MP0003693_abnormal_embryo_hatching2.26642244
26MP0003221_abnormal_cardiomyocyte_apopto2.25299184
27MP0004185_abnormal_adipocyte_glucose2.23774157
28MP0010094_abnormal_chromosome_stability2.23604781
29MP0003137_abnormal_impulse_conducting2.22465289
30MP0004233_abnormal_muscle_weight2.22108994
31MP0004484_altered_response_of2.11831988
32MP0004957_abnormal_blastocyst_morpholog2.02005123
33MP0003077_abnormal_cell_cycle1.98958513
34MP0000759_abnormal_skeletal_muscle1.98142469
35MP0000747_muscle_weakness1.97493612
36MP0001661_extended_life_span1.96017202
37MP0006036_abnormal_mitochondrial_physio1.87494382
38MP0004145_abnormal_muscle_electrophysio1.84170950
39MP0005369_muscle_phenotype1.80011790
40MP0005375_adipose_tissue_phenotype1.76311068
41MP0008932_abnormal_embryonic_tissue1.74003581
42MP0003828_pulmonary_edema1.69393495
43MP0009672_abnormal_birth_weight1.69349768
44MP0004085_abnormal_heartbeat1.59469883
45MP0002877_abnormal_melanocyte_morpholog1.53690567
46MP0002971_abnormal_brown_adipose1.40381685
47MP0003566_abnormal_cell_adhesion1.38317264
48MP0003567_abnormal_fetal_cardiomyocyte1.33615334
49MP0008057_abnormal_DNA_replication1.31944425
50MP0000566_synostosis1.31127615
51MP0002332_abnormal_exercise_endurance1.29291411
52MP0002080_prenatal_lethality1.23714047
53MP0000003_abnormal_adipose_tissue1.22839289
54MP0001346_abnormal_lacrimal_gland1.21785555
55MP0004510_myositis1.20034281
56MP0000350_abnormal_cell_proliferation1.19528114
57MP0002009_preneoplasia1.17856952
58MP0001697_abnormal_embryo_size1.16925405
59MP0000013_abnormal_adipose_tissue1.15839937
60MP0002127_abnormal_cardiovascular_syste1.14991741
61MP0000266_abnormal_heart_morphology1.12360381
62MP0003950_abnormal_plasma_membrane1.09173518
63MP0003315_abnormal_perineum_morphology1.08459861
64MP0008438_abnormal_cutaneous_collagen1.08001481
65MP0005275_abnormal_skin_tensile1.06479129
66MP0006035_abnormal_mitochondrial_morpho1.06273119
67MP0010352_gastrointestinal_tract_polyps1.04006711
68MP0004197_abnormal_fetal_growth/weight/1.03329699
69MP0000343_altered_response_to1.02647968
70MP0005409_darkened_coat_color1.01570427
71MP0008961_abnormal_basal_metabolism0.99155211
72MP0008007_abnormal_cellular_replicative0.97412921
73MP0000733_abnormal_muscle_development0.97383770
74MP0009697_abnormal_copulation0.95596667
75MP0005266_abnormal_metabolism0.94488848
76MP0005623_abnormal_meninges_morphology0.93984724
77MP0002234_abnormal_pharynx_morphology0.92926284
78MP0002086_abnormal_extraembryonic_tissu0.91567044
79MP0000537_abnormal_urethra_morphology0.87956122
80MP0005501_abnormal_skin_physiology0.87194396
81MP0001727_abnormal_embryo_implantation0.85560812
82MP0003279_aneurysm0.83715876
83MP0010234_abnormal_vibrissa_follicle0.83617391
84MP0009115_abnormal_fat_cell0.83295667
85MP0003656_abnormal_erythrocyte_physiolo0.83091859
86MP0002970_abnormal_white_adipose0.82933194
87MP0002085_abnormal_embryonic_tissue0.81901648
88MP0004264_abnormal_extraembryonic_tissu0.81014397
89MP0004272_abnormal_basement_membrane0.80065983
90MP0000313_abnormal_cell_death0.78866041
91MP0005058_abnormal_lysosome_morphology0.78029939
92MP0005165_increased_susceptibility_to0.77901723
93MP0008995_early_reproductive_senescence0.75916756
94MP0003984_embryonic_growth_retardation0.75510968
95MP0002084_abnormal_developmental_patter0.74657226
96MP0002088_abnormal_embryonic_growth/wei0.73804884
97MP0003806_abnormal_nucleotide_metabolis0.72011567
98MP0003959_abnormal_lean_body0.71933102
99MP0000678_abnormal_parathyroid_gland0.71842486
100MP0003941_abnormal_skin_development0.69627614
101MP0002128_abnormal_blood_circulation0.68754314
102MP0008058_abnormal_DNA_repair0.68259099
103MP0004147_increased_porphyrin_level0.67204977
104MP0005334_abnormal_fat_pad0.66930622
105MP0003123_paternal_imprinting0.66537447
106MP0002249_abnormal_larynx_morphology0.66198853
107MP0003385_abnormal_body_wall0.65847386
108MP0005076_abnormal_cell_differentiation0.64781730
109MP0002909_abnormal_adrenal_gland0.64560523
110MP0003329_amyloid_beta_deposits0.64399603
111MP0010329_abnormal_lipoprotein_level0.64313211
112MP0005187_abnormal_penis_morphology0.63545136
113MP0002078_abnormal_glucose_homeostasis0.63283985
114MP0004782_abnormal_surfactant_physiolog0.63205108
115MP0002118_abnormal_lipid_homeostasis0.62899430
116MP0009703_decreased_birth_body0.62434471
117MP0002108_abnormal_muscle_morphology0.62432455
118MP0005535_abnormal_body_temperature0.59853072
119MP0004043_abnormal_pH_regulation0.58075099
120MP0005319_abnormal_enzyme/_coenzyme0.57539969
121MP0009840_abnormal_foam_cell0.56977085
122MP0000230_abnormal_systemic_arterial0.56418583
123MP0002796_impaired_skin_barrier0.55033772
124MP0001672_abnormal_embryogenesis/_devel0.54869049
125MP0005380_embryogenesis_phenotype0.54869049
126MP0001730_embryonic_growth_arrest0.54700482
127MP0005584_abnormal_enzyme/coenzyme_acti0.52834018
128MP0002925_abnormal_cardiovascular_devel0.50922904
129MP0004858_abnormal_nervous_system0.50895896
130MP0005448_abnormal_energy_balance0.50749472
131MP0006054_spinal_hemorrhage0.50013770
132MP0009780_abnormal_chondrocyte_physiolo0.49250988
133MP0005452_abnormal_adipose_tissue0.49089214
134MP0005332_abnormal_amino_acid0.47054477
135MP0009384_cardiac_valve_regurgitation0.44065714
136MP0003948_abnormal_gas_homeostasis0.42723935
137MP0001849_ear_inflammation0.42328388
138MP0010368_abnormal_lymphatic_system0.42271659
139MP0001784_abnormal_fluid_regulation0.39996686
140MP0001614_abnormal_blood_vessel0.39824074
141MP0005451_abnormal_body_composition0.39738287

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.40150676
2Exercise-induced myalgia (HP:0003738)5.48550220
3Myoglobinuria (HP:0002913)5.46766888
4Ventricular tachycardia (HP:0004756)5.45557863
5Exercise-induced muscle cramps (HP:0003710)5.42516698
6Right ventricular cardiomyopathy (HP:0011663)4.66473036
7Calf muscle hypertrophy (HP:0008981)4.60570384
8Rhabdomyolysis (HP:0003201)4.52400626
9Muscle fiber splitting (HP:0003555)4.50460984
10Hyporeflexia of lower limbs (HP:0002600)4.34444294
11Atrial fibrillation (HP:0005110)4.33588834
12Lipoatrophy (HP:0100578)4.28609475
13Muscle hypertrophy of the lower extremities (HP:0008968)4.23322725
14Centrally nucleated skeletal muscle fibers (HP:0003687)4.22442314
15Primary atrial arrhythmia (HP:0001692)4.09430247
16Increased connective tissue (HP:0009025)4.05501205
17Abnormality of the calf musculature (HP:0001430)4.03110699
18Palpitations (HP:0001962)4.00250250
19Supraventricular tachycardia (HP:0004755)3.96786796
20Difficulty running (HP:0009046)3.93072603
21Supraventricular arrhythmia (HP:0005115)3.91951083
22Bundle branch block (HP:0011710)3.87436742
23Abnormality of the left ventricular outflow tract (HP:0011103)3.84834389
24Subaortic stenosis (HP:0001682)3.84834389
25Abnormal gallbladder physiology (HP:0012438)3.66511158
26Cholecystitis (HP:0001082)3.66511158
27Syncope (HP:0001279)3.66445505
28Dilated cardiomyopathy (HP:0001644)3.51635196
29EMG: myopathic abnormalities (HP:0003458)3.40251441
30Ventricular arrhythmia (HP:0004308)3.39782905
31Conjunctival hamartoma (HP:0100780)3.32375055
32Progressive muscle weakness (HP:0003323)3.29475603
33Asymmetric septal hypertrophy (HP:0001670)3.28927062
34Ventricular fibrillation (HP:0001663)3.15934665
35Prolonged QT interval (HP:0001657)3.15065234
36Atrioventricular block (HP:0001678)3.05232588
37Heart block (HP:0012722)3.04353910
38Type 1 muscle fiber predominance (HP:0003803)3.01008871
39Distal lower limb amyotrophy (HP:0008944)2.95711692
40Myotonia (HP:0002486)2.95430807
41Difficulty climbing stairs (HP:0003551)2.92642949
42Ketoacidosis (HP:0001993)2.91672103
43Abnormal atrioventricular conduction (HP:0005150)2.91057904
44Hypoglycemic coma (HP:0001325)2.88900841
45Muscle stiffness (HP:0003552)2.84242148
46Abnormality of fatty-acid metabolism (HP:0004359)2.78208838
47Hepatic necrosis (HP:0002605)2.73313609
48Hamartoma of the eye (HP:0010568)2.66728446
49Increased variability in muscle fiber diameter (HP:0003557)2.62931726
50Pheochromocytoma (HP:0002666)2.62668555
51Increased muscle lipid content (HP:0009058)2.62124242
52Hyperglycinuria (HP:0003108)2.59841727
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57385327
54Dicarboxylic aciduria (HP:0003215)2.57385327
55Rimmed vacuoles (HP:0003805)2.54898145
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54474104
57Abnormality of alanine metabolism (HP:0010916)2.54474104
58Hyperalaninemia (HP:0003348)2.54474104
59Muscle fiber inclusion bodies (HP:0100299)2.53468799
60Calcaneovalgus deformity (HP:0001848)2.51782233
61Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.50429854
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49908094
63Abnormality of skeletal muscle fiber size (HP:0012084)2.45640072
64Neoplasm of the adrenal gland (HP:0100631)2.43191103
65Dysmetric saccades (HP:0000641)2.41833344
66Cholelithiasis (HP:0001081)2.37500128
67Ragged-red muscle fibers (HP:0003200)2.35090207
68Limb-girdle muscle atrophy (HP:0003797)2.34444887
69Abnormality of glycolysis (HP:0004366)2.32554736
70Increased serum pyruvate (HP:0003542)2.32554736
71Chromsome breakage (HP:0040012)2.31804071
72Athetosis (HP:0002305)2.31530543
73Neuroendocrine neoplasm (HP:0100634)2.27738774
74Neck muscle weakness (HP:0000467)2.27285230
75Abnormal EKG (HP:0003115)2.27117666
76Distal arthrogryposis (HP:0005684)2.24644516
77Abnormal mitochondria in muscle tissue (HP:0008316)2.20363390
78Ulnar deviation of the wrist (HP:0003049)2.19731632
79Progressive external ophthalmoplegia (HP:0000590)2.17517634
80Round ear (HP:0100830)2.15731979
81Ketosis (HP:0001946)2.15628717
82Abnormality of glycine metabolism (HP:0010895)2.13716324
83Abnormality of serine family amino acid metabolism (HP:0010894)2.13716324
84Abnormality of the calcaneus (HP:0008364)2.13633373
85Mildly elevated creatine phosphokinase (HP:0008180)2.13589079
86Hyperammonemia (HP:0001987)2.13540223
87Multiple enchondromatosis (HP:0005701)2.12453304
88Palmoplantar keratoderma (HP:0000982)2.11894355
89Abnormality of the foot musculature (HP:0001436)2.11847421
90Microvesicular hepatic steatosis (HP:0001414)2.10754279
91Deformed tarsal bones (HP:0008119)2.10601212
92Reticulocytosis (HP:0001923)2.10305194
93Hepatocellular necrosis (HP:0001404)2.09038850
94Esophageal neoplasm (HP:0100751)2.08039687
95Neoplasm of head and neck (HP:0012288)2.08039687
96Lower limb amyotrophy (HP:0007210)2.04740223
97Foot dorsiflexor weakness (HP:0009027)2.03895279
98Angiofibromas (HP:0010615)2.02808596
99Adenoma sebaceum (HP:0009720)2.02808596
100Abnormal gallbladder morphology (HP:0012437)2.01421258
101Scapular winging (HP:0003691)2.01091221
102Neonatal death (HP:0003811)1.98999918
103Hyperacusis (HP:0010780)1.98722849
104Distal lower limb muscle weakness (HP:0009053)1.97797345
105Facial diplegia (HP:0001349)1.96344969
106Nemaline bodies (HP:0003798)1.96281611
107Nausea (HP:0002018)1.95220039
108Left ventricular hypertrophy (HP:0001712)1.92606523
109Lymphangioma (HP:0100764)1.92237596
110Areflexia of lower limbs (HP:0002522)1.91265426
111Gout (HP:0001997)1.91238097
112Back pain (HP:0003418)1.90590030
113Acute encephalopathy (HP:0006846)1.85790704
114Myopathic facies (HP:0002058)1.85751486
115Acute necrotizing encephalopathy (HP:0006965)1.85649090
116Termporal pattern (HP:0011008)1.85264645
117Insidious onset (HP:0003587)1.85264645
118Lactic acidosis (HP:0003128)1.85057048
119Cortical dysplasia (HP:0002539)1.84397789
120Increased intramyocellular lipid droplets (HP:0012240)1.84146015
121Generalized muscle weakness (HP:0003324)1.83874199
122Spinal rigidity (HP:0003306)1.83287363
123Neoplasm of the peripheral nervous system (HP:0100007)1.81093768
124Tinnitus (HP:0000360)1.80719645
125Abnormality of reticulocytes (HP:0004312)1.80585431
126Sudden cardiac death (HP:0001645)1.79385894
127EMG: neuropathic changes (HP:0003445)1.77682171
128Generalized aminoaciduria (HP:0002909)1.77532349
129Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77512834
130Proximal amyotrophy (HP:0007126)1.73078055
131Trismus (HP:0000211)1.70358346
132Abnormality of the gallbladder (HP:0005264)1.69727436
133Increased nuchal translucency (HP:0010880)1.65739960
134Insomnia (HP:0100785)1.63646390
135Septate vagina (HP:0001153)1.60819131
136Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60203750
137Achilles tendon contracture (HP:0001771)1.60105011
138Abnormality of the salivary glands (HP:0010286)1.58977397
139Malignant hyperthermia (HP:0002047)1.58917709
140Frequent falls (HP:0002359)1.56441189
141Metatarsus adductus (HP:0001840)1.54424278
142Bulbar palsy (HP:0001283)1.54259218
143Abnormality of the tricuspid valve (HP:0001702)1.53915020
144Upper limb amyotrophy (HP:0009129)1.53829859
145Distal upper limb amyotrophy (HP:0007149)1.53829859
146Breech presentation (HP:0001623)1.51663551
147Microglossia (HP:0000171)1.51555432
148Asymmetry of the thorax (HP:0001555)1.51269816
149Exercise intolerance (HP:0003546)1.47634627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.82686300
2TTN4.71170763
3PDK33.99977650
4PDK43.99977650
5PKN23.87948187
6LMTK23.79287437
7NEK13.59058395
8PHKG13.16613156
9PHKG23.16613156
10OBSCN2.97998439
11CDK122.96080508
12EIF2AK12.75658592
13SMG12.62237406
14BCKDK2.54367578
15DMPK2.35311209
16PDK22.21700942
17TAOK22.14841558
18MYLK2.14091537
19BUB12.04634271
20SRPK11.81544762
21PRPF4B1.68796716
22EEF2K1.59117556
23RIPK11.54174952
24PIK3CA1.49965411
25STK241.48255359
26TSSK61.43387917
27ILK1.38105422
28LATS21.36422649
29VRK21.31122630
30FGFR41.28696661
31BRD41.21378698
32PAK31.18823803
33CDK71.18217785
34CAMK1D1.17342828
35WEE11.17198459
36IRAK31.14212055
37PDGFRA1.13569105
38BRSK11.11148499
39MAPKAPK31.11010385
40SIK11.10129742
41CDK81.09596336
42NME21.08218321
43CDC71.05861117
44MAP2K31.04189577
45PBK1.01993000
46KSR21.01810340
47MAP3K101.00484260
48PRKD30.89661035
49PRKAA10.88318008
50LRRK20.88279671
51MAP3K70.88195413
52MAP3K50.87496472
53PTK60.85474249
54PRKD10.83692956
55TAOK10.80959393
56PAK60.80704317
57CHEK10.80564583
58PINK10.79468760
59LATS10.79231411
60ROCK10.79042091
61PRKAA20.78164514
62STK38L0.74655493
63TIE10.74563735
64CDK60.72358405
65CCNB10.72191196
66CHEK20.71242016
67ATR0.69676841
68RAF10.69610071
69CAMK1G0.69065093
70RET0.68893633
71EPHA20.68206158
72MAPK120.67338628
73NEK20.67280618
74TESK20.66494942
75LIMK10.66334404
76ARAF0.62589757
77EPHB10.61735269
78SCYL20.61617360
79STK380.60444996
80CDC42BPA0.58092766
81CDK10.57573200
82AURKB0.56531278
83MAP2K10.55369372
84KSR10.54778803
85ERN10.53950408
86FLT30.53945660
87MAP2K40.53751794
88MOS0.53507207
89BRAF0.53351327
90MTOR0.52997562
91DAPK30.52114606
92CDK20.51613116
93NEK90.50225194
94FGFR10.50154861
95PDPK10.49471874
96TESK10.49431563
97EIF2AK30.48270474
98AURKA0.47231041
99STK40.46497216
100CAMK2D0.45465738
101EIF2AK20.44561209
102CDK90.44372421
103PDK10.44313507
104AKT20.43832460
105CLK10.43649878
106FER0.43597773
107MAP3K30.43106159
108ROCK20.42942778
109ICK0.42645030
110CDK150.41661393
111CDK11A0.41639993
112MST1R0.41103139
113MAP3K130.40857689
114EPHB20.40760592
115MAPK110.40591304
116CDK180.40348814
117RPS6KB10.40067641
118TTK0.38935068
119PTK2B0.38560921
120TRPM70.38522090
121MAP3K80.38303800
122NME10.37858831
123PTK20.37593034
124BMX0.37257841
125PLK10.37018388
126CDK140.36947549
127CDK40.35686917
128PRKACG0.35304659
129MAP3K90.34984956
130ALK0.34464697
131MUSK0.34415614
132PAK20.32690947
133KDR0.32366002
134PRKCH0.31660367
135PAK40.31160857
136STK100.30245215
137RPS6KA10.30100397
138MAP3K40.29494446
139MAP3K110.28742479
140MAP2K60.27558966
141PRKACB0.27002207
142TGFBR10.26700975
143PRKG20.26677770
144MINK10.25619724
145MAP3K60.25591828
146SGK30.25518592
147RPS6KB20.24323568
148CAMK40.24067811

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.79452438
2* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.43072759
3Propanoate metabolism_Homo sapiens_hsa006403.66485610
4Fatty acid degradation_Homo sapiens_hsa000713.23758631
5* Carbon metabolism_Homo sapiens_hsa012002.95549220
6Fatty acid metabolism_Homo sapiens_hsa012122.90414106
7Cardiac muscle contraction_Homo sapiens_hsa042602.70156993
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50518703
9Dilated cardiomyopathy_Homo sapiens_hsa054142.46179581
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43075795
11Pyruvate metabolism_Homo sapiens_hsa006202.38031868
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.36984245
13DNA replication_Homo sapiens_hsa030302.22919042
14Fatty acid biosynthesis_Homo sapiens_hsa000612.03664886
15Parkinsons disease_Homo sapiens_hsa050121.83682673
16PPAR signaling pathway_Homo sapiens_hsa033201.81481739
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73494735
18* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70157245
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.69773230
20* Biosynthesis of amino acids_Homo sapiens_hsa012301.54355777
21Oxidative phosphorylation_Homo sapiens_hsa001901.50153676
22Cell cycle_Homo sapiens_hsa041101.43479985
23Viral myocarditis_Homo sapiens_hsa054161.43441586
24Butanoate metabolism_Homo sapiens_hsa006501.42893984
25Base excision repair_Homo sapiens_hsa034101.41738165
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38851799
27RNA transport_Homo sapiens_hsa030131.37171477
28mRNA surveillance pathway_Homo sapiens_hsa030151.35752937
29One carbon pool by folate_Homo sapiens_hsa006701.34541011
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.30693845
31Mismatch repair_Homo sapiens_hsa034301.30578688
32Alzheimers disease_Homo sapiens_hsa050101.24982150
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23957148
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.20142913
35Glucagon signaling pathway_Homo sapiens_hsa049221.18563201
36Insulin resistance_Homo sapiens_hsa049311.16276347
37Spliceosome_Homo sapiens_hsa030401.16259863
38Insulin signaling pathway_Homo sapiens_hsa049101.14821853
39AMPK signaling pathway_Homo sapiens_hsa041521.10719702
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09749701
41Huntingtons disease_Homo sapiens_hsa050161.07489459
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05429498
43Nucleotide excision repair_Homo sapiens_hsa034201.03232666
44Fat digestion and absorption_Homo sapiens_hsa049750.99591812
45Sulfur relay system_Homo sapiens_hsa041220.95590003
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95292612
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.95049404
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94742957
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93137675
50Nitrogen metabolism_Homo sapiens_hsa009100.92092326
51Fatty acid elongation_Homo sapiens_hsa000620.91393849
52Starch and sucrose metabolism_Homo sapiens_hsa005000.91159790
53Galactose metabolism_Homo sapiens_hsa000520.84537352
54HIF-1 signaling pathway_Homo sapiens_hsa040660.82336748
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81905517
56Arginine biosynthesis_Homo sapiens_hsa002200.81177935
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76350205
58beta-Alanine metabolism_Homo sapiens_hsa004100.75763766
59Fructose and mannose metabolism_Homo sapiens_hsa000510.74534564
60Proteasome_Homo sapiens_hsa030500.74001627
61Bladder cancer_Homo sapiens_hsa052190.73558701
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73200772
63Lysine degradation_Homo sapiens_hsa003100.71902632
64Non-homologous end-joining_Homo sapiens_hsa034500.71351332
65Glycerolipid metabolism_Homo sapiens_hsa005610.69289576
66Focal adhesion_Homo sapiens_hsa045100.68752730
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68400705
68Tight junction_Homo sapiens_hsa045300.67651526
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66738749
70Acute myeloid leukemia_Homo sapiens_hsa052210.66192269
71Steroid biosynthesis_Homo sapiens_hsa001000.65893350
72Pentose phosphate pathway_Homo sapiens_hsa000300.64829395
73Tryptophan metabolism_Homo sapiens_hsa003800.62907693
74Circadian rhythm_Homo sapiens_hsa047100.61079611
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60887286
76Pyrimidine metabolism_Homo sapiens_hsa002400.60695487
77Adherens junction_Homo sapiens_hsa045200.57680880
78mTOR signaling pathway_Homo sapiens_hsa041500.56729650
79Pancreatic cancer_Homo sapiens_hsa052120.55315774
80Gastric acid secretion_Homo sapiens_hsa049710.54278643
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53985632
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52736469
83Oxytocin signaling pathway_Homo sapiens_hsa049210.50747651
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49652794
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48851941
86Type II diabetes mellitus_Homo sapiens_hsa049300.47043141
87VEGF signaling pathway_Homo sapiens_hsa043700.46565309
88Purine metabolism_Homo sapiens_hsa002300.46407846
89Prion diseases_Homo sapiens_hsa050200.44327291
90MicroRNAs in cancer_Homo sapiens_hsa052060.43912345
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43610390
92Proteoglycans in cancer_Homo sapiens_hsa052050.42112127
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.40589126
94Tyrosine metabolism_Homo sapiens_hsa003500.39409799
95Renin secretion_Homo sapiens_hsa049240.38959428
96Prostate cancer_Homo sapiens_hsa052150.37984052
97Bile secretion_Homo sapiens_hsa049760.37417889
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37162818
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37078490
100ErbB signaling pathway_Homo sapiens_hsa040120.36985633
101N-Glycan biosynthesis_Homo sapiens_hsa005100.33744290
102Calcium signaling pathway_Homo sapiens_hsa040200.33683157
103Small cell lung cancer_Homo sapiens_hsa052220.33661020
104Vitamin B6 metabolism_Homo sapiens_hsa007500.32229691
105Peroxisome_Homo sapiens_hsa041460.31751997
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30575916
107Colorectal cancer_Homo sapiens_hsa052100.30222668
108Caffeine metabolism_Homo sapiens_hsa002320.29955160
109Amoebiasis_Homo sapiens_hsa051460.29845067
110Arginine and proline metabolism_Homo sapiens_hsa003300.29339689
111Gap junction_Homo sapiens_hsa045400.28749914
112Viral carcinogenesis_Homo sapiens_hsa052030.27903514
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27869443
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.27446007
115GnRH signaling pathway_Homo sapiens_hsa049120.26773358
116RNA polymerase_Homo sapiens_hsa030200.26135157
117Phenylalanine metabolism_Homo sapiens_hsa003600.25608361
118RNA degradation_Homo sapiens_hsa030180.25542388
119Endometrial cancer_Homo sapiens_hsa052130.25032274
120Renal cell carcinoma_Homo sapiens_hsa052110.23429047
121ECM-receptor interaction_Homo sapiens_hsa045120.23383853
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.22846068
123Thyroid cancer_Homo sapiens_hsa052160.22519627
124Glioma_Homo sapiens_hsa052140.22346156
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21293523
126Oocyte meiosis_Homo sapiens_hsa041140.21264331
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18996103
128Estrogen signaling pathway_Homo sapiens_hsa049150.18669860
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.18268314
130cAMP signaling pathway_Homo sapiens_hsa040240.17888561
131Hippo signaling pathway_Homo sapiens_hsa043900.17147643
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16543074
133Renin-angiotensin system_Homo sapiens_hsa046140.16233153
134Non-small cell lung cancer_Homo sapiens_hsa052230.16058610
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15728564
136Chronic myeloid leukemia_Homo sapiens_hsa052200.14754904
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.14492622

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