CSAD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the group 2 decarboxylase family. A similar protein in rodents plays a role in multiple biological processes as the rate-limiting enzyme in taurine biosynthesis, catalyzing the decarboxylation of cysteinesulfinate to hypotaurine. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.93719597
2L-phenylalanine catabolic process (GO:0006559)6.93719597
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.91542856
4L-phenylalanine metabolic process (GO:0006558)6.91542856
5aromatic amino acid family catabolic process (GO:0009074)6.30731817
6glyoxylate metabolic process (GO:0046487)6.16304611
7cysteine metabolic process (GO:0006534)5.76826251
8tryptophan catabolic process (GO:0006569)5.75829939
9indole-containing compound catabolic process (GO:0042436)5.75829939
10indolalkylamine catabolic process (GO:0046218)5.75829939
11* sulfur amino acid catabolic process (GO:0000098)5.59568692
12bile acid biosynthetic process (GO:0006699)5.50808529
13kynurenine metabolic process (GO:0070189)5.47209503
14tryptophan metabolic process (GO:0006568)5.38748780
15behavioral response to nicotine (GO:0035095)5.31115831
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.14280301
17serine family amino acid catabolic process (GO:0009071)5.13297723
18lysine catabolic process (GO:0006554)5.09461403
19lysine metabolic process (GO:0006553)5.09461403
20alpha-linolenic acid metabolic process (GO:0036109)5.07822051
21homocysteine metabolic process (GO:0050667)4.99252081
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.94739948
23complement activation, alternative pathway (GO:0006957)4.90494990
24bile acid metabolic process (GO:0008206)4.72594663
25urea cycle (GO:0000050)4.69434667
26urea metabolic process (GO:0019627)4.69434667
27amino-acid betaine metabolic process (GO:0006577)4.64671963
28aromatic amino acid family metabolic process (GO:0009072)4.62225520
29acetyl-CoA metabolic process (GO:0006084)4.60160099
30regulation of protein activation cascade (GO:2000257)4.60050526
31proline metabolic process (GO:0006560)4.49055881
32negative regulation of fibrinolysis (GO:0051918)4.44766893
33acylglycerol homeostasis (GO:0055090)4.44073229
34triglyceride homeostasis (GO:0070328)4.44073229
35nitrogen cycle metabolic process (GO:0071941)4.41387510
36alpha-amino acid catabolic process (GO:1901606)4.41279495
37regulation of complement activation (GO:0030449)4.37511229
38fatty acid beta-oxidation (GO:0006635)4.37296699
39drug transmembrane transport (GO:0006855)4.33801599
40regulation of fibrinolysis (GO:0051917)4.32109446
41peptidyl-glutamic acid carboxylation (GO:0017187)4.30164517
42protein carboxylation (GO:0018214)4.30164517
43serine family amino acid metabolic process (GO:0009069)4.24947023
44regulation of triglyceride catabolic process (GO:0010896)4.23655018
45high-density lipoprotein particle remodeling (GO:0034375)4.23328484
46tyrosine metabolic process (GO:0006570)4.23057998
47urate metabolic process (GO:0046415)4.22333826
48short-chain fatty acid metabolic process (GO:0046459)4.22188920
49cellular ketone body metabolic process (GO:0046950)4.21764610
50* cellular amino acid catabolic process (GO:0009063)4.21328136
51fatty acid oxidation (GO:0019395)4.18725440
52lipid oxidation (GO:0034440)4.09629947
53cellular modified amino acid catabolic process (GO:0042219)4.08663278
54NAD biosynthetic process (GO:0009435)4.08516848
55fatty acid catabolic process (GO:0009062)4.05787744
56coenzyme catabolic process (GO:0009109)4.04888866
57ethanol oxidation (GO:0006069)4.02398323
58amine catabolic process (GO:0009310)4.00407834
59cellular biogenic amine catabolic process (GO:0042402)4.00407834
60proline biosynthetic process (GO:0006561)4.00120567
61valine metabolic process (GO:0006573)3.99780321
62indolalkylamine metabolic process (GO:0006586)3.99013740
63regulation of sequestering of triglyceride (GO:0010889)3.95679063
64glutamate metabolic process (GO:0006536)3.93380168
65cytolysis (GO:0019835)3.93247827
66* organic acid catabolic process (GO:0016054)3.89787687
67* carboxylic acid catabolic process (GO:0046395)3.89787687
68monocarboxylic acid catabolic process (GO:0072329)3.89714347
69glycine metabolic process (GO:0006544)3.84256534
70benzene-containing compound metabolic process (GO:0042537)3.83139775
71plasma lipoprotein particle clearance (GO:0034381)3.80327595
72regulation of cholesterol homeostasis (GO:2000188)3.79534688
732-oxoglutarate metabolic process (GO:0006103)3.74703342
74glutamine family amino acid biosynthetic process (GO:0009084)3.73264815
75negative regulation of fatty acid biosynthetic process (GO:0045717)3.73096577
76serine family amino acid biosynthetic process (GO:0009070)3.72015475
77cellular glucuronidation (GO:0052695)3.71994045
78biotin metabolic process (GO:0006768)3.71585409
79reverse cholesterol transport (GO:0043691)3.70330645
80drug catabolic process (GO:0042737)3.69992477
81pyrimidine nucleobase catabolic process (GO:0006208)3.68744127
82branched-chain amino acid metabolic process (GO:0009081)3.68575917
83heme transport (GO:0015886)3.67926771
84very-low-density lipoprotein particle assembly (GO:0034379)3.67513191
85plasma lipoprotein particle remodeling (GO:0034369)3.65250695
86protein-lipid complex remodeling (GO:0034368)3.65250695
87macromolecular complex remodeling (GO:0034367)3.65250695
88branched-chain amino acid catabolic process (GO:0009083)3.64980471
89ketone body metabolic process (GO:1902224)3.64309596
90carnitine metabolic process (GO:0009437)3.63931372
91regulation of cholesterol esterification (GO:0010872)3.63733681
92response to nitrosative stress (GO:0051409)3.61381661
93aspartate family amino acid catabolic process (GO:0009068)3.59996706
94drug transport (GO:0015893)3.57348740
95bile acid and bile salt transport (GO:0015721)3.56996181
96fucose catabolic process (GO:0019317)3.50750308
97L-fucose metabolic process (GO:0042354)3.50750308
98L-fucose catabolic process (GO:0042355)3.50750308
99positive regulation of fatty acid beta-oxidation (GO:0032000)3.48447899
100cholesterol efflux (GO:0033344)3.48089560
101negative regulation of sterol transport (GO:0032372)3.46436924
102negative regulation of cholesterol transport (GO:0032375)3.46436924
103cholesterol homeostasis (GO:0042632)3.45289971
104plasma lipoprotein particle assembly (GO:0034377)3.44734104
105positive regulation of CREB transcription factor activity (GO:0032793)3.42701822
106pyridine nucleotide biosynthetic process (GO:0019363)3.41996208
107nicotinamide nucleotide biosynthetic process (GO:0019359)3.41996208
108sterol homeostasis (GO:0055092)3.40760421
109macroautophagy (GO:0016236)3.25445876
110response to pheromone (GO:0019236)3.21529729
111somite development (GO:0061053)3.12434358
112behavioral response to ethanol (GO:0048149)3.04798531
113nucleobase catabolic process (GO:0046113)3.04508830
114positive regulation of triglyceride biosynthetic process (GO:0010867)3.03691033
115regulation of triglyceride biosynthetic process (GO:0010866)2.99569038
116positive regulation of fatty acid oxidation (GO:0046321)2.93636357
117negative regulation of Rho protein signal transduction (GO:0035024)2.92870225
118adaptation of signaling pathway (GO:0023058)2.92563348
119positive regulation of histone deacetylation (GO:0031065)2.92522962
120regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90613815
121gamma-aminobutyric acid transport (GO:0015812)2.87969710
122startle response (GO:0001964)2.84688482
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82048213
124negative regulation of interleukin-1 production (GO:0032692)2.80460056
125detection of bacterium (GO:0016045)2.77688965
126neuronal action potential (GO:0019228)2.74012846
127phosphatidylglycerol biosynthetic process (GO:0006655)2.72324575
128regulation of hydrogen peroxide metabolic process (GO:0010310)2.70763936
129negative regulation of interleukin-1 beta production (GO:0032691)2.69060764
130positive regulation of oligodendrocyte differentiation (GO:0048714)2.67899515
131response to misfolded protein (GO:0051788)2.65117148
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64766708
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.64766708
134detection of other organism (GO:0098543)2.61210780
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.60283481
136negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59506043
137reciprocal DNA recombination (GO:0035825)2.59071053
138reciprocal meiotic recombination (GO:0007131)2.59071053
139exogenous drug catabolic process (GO:0042738)2.57266944
140nephron tubule morphogenesis (GO:0072078)2.53684920
141nephron epithelium morphogenesis (GO:0072088)2.53684920
142positive regulation of triglyceride metabolic process (GO:0090208)2.48468078
143head development (GO:0060322)2.47976318
144cAMP catabolic process (GO:0006198)2.46124543
145gamma-aminobutyric acid signaling pathway (GO:0007214)2.45056470
146cilium or flagellum-dependent cell motility (GO:0001539)2.44244582
147membrane depolarization during action potential (GO:0086010)2.43591598
148activated T cell proliferation (GO:0050798)2.43404286
149regulation of natural killer cell differentiation (GO:0032823)2.41472771
150regulation of triglyceride metabolic process (GO:0090207)2.36161192
151alanine transport (GO:0032328)2.36025621
152positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.35984008
153white fat cell differentiation (GO:0050872)2.35862849
154male sex determination (GO:0030238)2.35612899
155positive regulation of protein kinase C signaling (GO:0090037)2.33608205
156regulation of histone deacetylation (GO:0031063)2.31987129
157pyridine-containing compound biosynthetic process (GO:0072525)2.26703509
158synaptic transmission, cholinergic (GO:0007271)2.25544815
159cell migration in hindbrain (GO:0021535)2.25354284
160toxin metabolic process (GO:0009404)2.24575947
161diacylglycerol metabolic process (GO:0046339)2.24094026
162epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.23503342
163S-adenosylmethionine metabolic process (GO:0046500)2.21665810
164detection of light stimulus involved in visual perception (GO:0050908)2.20724152
165detection of light stimulus involved in sensory perception (GO:0050962)2.20724152
166cAMP metabolic process (GO:0046058)2.20537661
167fucosylation (GO:0036065)2.19304838
168cornea development in camera-type eye (GO:0061303)2.18582887
169opioid receptor signaling pathway (GO:0038003)2.18452593
170N-acetylglucosamine metabolic process (GO:0006044)2.18337463
171epithelial cilium movement (GO:0003351)2.18318609
172alkaloid metabolic process (GO:0009820)2.18179916
173brown fat cell differentiation (GO:0050873)2.17121177
174membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.17042505
175hydrogen peroxide biosynthetic process (GO:0050665)2.16722039
176sex determination (GO:0007530)2.15377381
177nonmotile primary cilium assembly (GO:0035058)2.14977369
178neuron cell-cell adhesion (GO:0007158)2.14550878
179negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.12697406
180axoneme assembly (GO:0035082)2.12389081
181negative regulation of mast cell activation (GO:0033004)2.11923106
182cAMP biosynthetic process (GO:0006171)2.11775815
183detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.11089974
184membrane hyperpolarization (GO:0060081)2.11088465
185cyclic nucleotide catabolic process (GO:0009214)2.10290547
186detection of biotic stimulus (GO:0009595)2.09849930
187fatty acid transmembrane transport (GO:1902001)2.09544299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.71649898
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.52527933
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.00501734
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.93143561
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.52758406
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.91355389
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.28575877
8EZH2_22144423_ChIP-Seq_EOC_Human4.17464906
9ZNF274_21170338_ChIP-Seq_K562_Hela3.92631151
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74006353
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.50252443
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74878491
13GBX2_23144817_ChIP-Seq_PC3_Human2.53202951
14VDR_22108803_ChIP-Seq_LS180_Human2.30378150
15DROSHA_22980978_ChIP-Seq_HELA_Human2.28218678
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01350512
17REST_21632747_ChIP-Seq_MESCs_Mouse2.01030131
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1555100
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90641514
20CLOCK_20551151_ChIP-Seq_293T_Human1.85775211
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83384332
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.73123426
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69355073
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.68872722
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67943116
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65988916
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65753976
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63655494
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63109185
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.60750858
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59225413
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.55727967
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55460813
34ER_23166858_ChIP-Seq_MCF-7_Human1.54972656
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53875636
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.50626645
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49131112
38* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.45477042
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45411888
40IGF1R_20145208_ChIP-Seq_DFB_Human1.40987066
41BCAT_22108803_ChIP-Seq_LS180_Human1.40414406
42ERA_21632823_ChIP-Seq_H3396_Human1.37718580
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37506411
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36744752
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.36198288
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35972175
47TAF2_19829295_ChIP-Seq_ESCs_Human1.35438342
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35278855
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35152217
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34257217
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32968288
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32896117
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32896117
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.30785291
55* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30132655
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29865924
57* GATA3_21878914_ChIP-Seq_MCF-7_Human1.29767333
58AR_21572438_ChIP-Seq_LNCaP_Human1.29664224
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.29581981
60LXR_22292898_ChIP-Seq_THP-1_Human1.28715731
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.27523299
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26997028
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26885973
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26504237
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26282805
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25890450
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25439553
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25267134
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23911161
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.22432172
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21603525
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21065017
73TP53_22573176_ChIP-Seq_HFKS_Human1.21015047
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20880036
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19233725
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19233725
77MYC_19829295_ChIP-Seq_ESCs_Human1.18464323
78NCOR_22424771_ChIP-Seq_293T_Human1.18390356
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18344880
80SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18048357
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17655959
82* OCT4_20526341_ChIP-Seq_ESCs_Human1.17557595
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15632699
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15001229
85CDX2_20551321_ChIP-Seq_CACO-2_Human1.14038833
86OCT4_19829295_ChIP-Seq_ESCs_Human1.13127485
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12825113
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12488057
89E2F1_20622854_ChIP-Seq_HELA_Human1.12371487
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.11735979
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10031364
92AR_25329375_ChIP-Seq_VCAP_Human1.09826916
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.09477218
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09111759
95PHF8_20622854_ChIP-Seq_HELA_Human1.07618840
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06121184
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05703653
98* STAT3_23295773_ChIP-Seq_U87_Human1.05644992
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.05601956
100YY1_22570637_ChIP-Seq_MALME-3M_Human1.05397923
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04920561
102TRIM28_21343339_ChIP-Seq_HEK293_Human1.04200647
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03501191
104RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03489129
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03162342
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03162342
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03162342
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03121230
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03117057
110BCL6_27268052_Chip-Seq_Bcells_Human1.02830887
111CTCF_20526341_ChIP-Seq_ESCs_Human1.02775682
112RUNX2_22187159_ChIP-Seq_PCA_Human1.02275471
113FOXH1_21741376_ChIP-Seq_ESCs_Human1.01233179
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01032162
115NANOG_20526341_ChIP-Seq_ESCs_Human1.00587103
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99440967
117TP53_16413492_ChIP-PET_HCT116_Human0.98070863
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97981914
119RAC3_21632823_ChIP-Seq_H3396_Human0.97247702
120IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97209814
121OCT1_27270436_Chip-Seq_PROSTATE_Human0.95647317
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94326504
123RNF2_27304074_Chip-Seq_NSC_Mouse0.94262841
124P68_20966046_ChIP-Seq_HELA_Human0.94058148
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93924084
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.93253221
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93218639
128RACK7_27058665_Chip-Seq_MCF-7_Human0.93217790
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92995296
130TAF15_26573619_Chip-Seq_HEK293_Human0.92062151
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91971656
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90907967
133* RARA_24833708_ChIP-Seq_LIVER_Mouse0.90827454
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90763453
135TCF4_23295773_ChIP-Seq_U87_Human0.90663521
136* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90300438
137HTT_18923047_ChIP-ChIP_STHdh_Human0.90261341
138POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89971529
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89588695
140IRF1_19129219_ChIP-ChIP_H3396_Human0.89466979
141BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.86836843
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85318098
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85126881
144* TET1_21451524_ChIP-Seq_MESCs_Mouse0.84359497
145* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81596563
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79622473
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77066665
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76270666
149CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75747350
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75442895
151GATA4_25053715_ChIP-Seq_YYC3_Human0.75194264
152SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73050232
153E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.71896949
154* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.70479609
155TCF3_18692474_ChIP-Seq_MESCs_Mouse0.69491919
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69384602
157SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65747952
158SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64480302
159SOX2_18692474_ChIP-Seq_MEFs_Mouse0.64419138
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.62673805
161PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62330070
162CTCF_21964334_ChIP-Seq_BJAB-B_Human0.61821050
163* SPI1_26923725_Chip-Seq_HPCs_Mouse0.61226225
164STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.61221014
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.60133408
166* MYC_27129775_Chip-Seq_CORNEA_Mouse0.59314392
167PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59056363
168PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58452875
169BCOR_27268052_Chip-Seq_Bcells_Human0.57622142
170TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57534762
171ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.57457318
172GATA1_22025678_ChIP-Seq_K562_Human0.56896730
173* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.56525063
174SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.56169163
175* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.55992172
176CSB_26484114_Chip-Seq_FIBROBLAST_Human0.55831900
177BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55571211
178PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.55015301
179ESR1_20079471_ChIP-ChIP_T-47D_Human0.54415509
180AUTS2_25519132_ChIP-Seq_293T-REX_Human0.53605780
181* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.53061405
182NANOG_16518401_ChIP-PET_MESCs_Mouse0.52565407
183CTCF_27219007_Chip-Seq_Bcells_Human0.52138996
184ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.51481050
185* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51120630
186GATA6_25053715_ChIP-Seq_YYC3_Human0.50376142
187* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.50092717
188NFIB_24661679_ChIP-Seq_LUNG_Mouse0.50048473
189ETS1_21867929_ChIP-Seq_TH2_Mouse0.49992609
190P63_26484246_Chip-Seq_KERATINOCYTES_Human0.49793370
191FLI1_21867929_ChIP-Seq_CD8_Mouse0.47827643
192MYC_19915707_ChIP-ChIP_AK7_Human0.47577316
193PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47353324
194CEBPB_22108803_ChIP-Seq_LS180_Human0.47267149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.55841533
2MP0005360_urolithiasis7.29575967
3MP0005365_abnormal_bile_salt6.29354898
4MP0005085_abnormal_gallbladder_physiolo6.11300819
5MP0008875_abnormal_xenobiotic_pharmacok4.47190656
6MP0003252_abnormal_bile_duct3.71931128
7MP0003806_abnormal_nucleotide_metabolis3.57165017
8MP0005332_abnormal_amino_acid3.32107406
9MP0010329_abnormal_lipoprotein_level3.30640876
10MP0004019_abnormal_vitamin_homeostasis2.82238987
11MP0003195_calcinosis2.75117886
12MP0001666_abnormal_nutrient_absorption2.47938378
13MP0009840_abnormal_foam_cell2.40927241
14MP0001968_abnormal_touch/_nociception2.40307729
15MP0005377_hearing/vestibular/ear_phenot2.38246658
16MP0003878_abnormal_ear_physiology2.38246658
17MP0003191_abnormal_cellular_cholesterol2.36567666
18MP0005083_abnormal_biliary_tract2.21920439
19MP0002118_abnormal_lipid_homeostasis2.21720488
20MP0002102_abnormal_ear_morphology2.18835971
21MP0005551_abnormal_eye_electrophysiolog2.13742097
22MP0000609_abnormal_liver_physiology2.05542411
23MP0002653_abnormal_ependyma_morphology2.00826734
24MP0005670_abnormal_white_adipose2.00196409
25MP0009745_abnormal_behavioral_response1.97905910
26MP0002138_abnormal_hepatobiliary_system1.94707834
27MP0001501_abnormal_sleep_pattern1.88946421
28MP0001986_abnormal_taste_sensitivity1.87298685
29MP0002736_abnormal_nociception_after1.87280601
30MP0005319_abnormal_enzyme/_coenzyme1.79613464
31MP0001486_abnormal_startle_reflex1.79124872
32MP0001485_abnormal_pinna_reflex1.77984842
33MP0001764_abnormal_homeostasis1.70828159
34MP0004742_abnormal_vestibular_system1.70543144
35MP0003868_abnormal_feces_composition1.69766011
36MP0009643_abnormal_urine_homeostasis1.66776994
37MP0003787_abnormal_imprinting1.64989897
38MP0004885_abnormal_endolymph1.64629507
39MP0002064_seizures1.64214026
40MP0009046_muscle_twitch1.64079495
41MP0003635_abnormal_synaptic_transmissio1.58589815
42MP0005584_abnormal_enzyme/coenzyme_acti1.57029568
43MP0002063_abnormal_learning/memory/cond1.54581379
44MP0002572_abnormal_emotion/affect_behav1.53696723
45MP0005646_abnormal_pituitary_gland1.52470913
46MP0002272_abnormal_nervous_system1.50754005
47MP0008877_abnormal_DNA_methylation1.50322113
48MP0001502_abnormal_circadian_rhythm1.49385877
49MP0003186_abnormal_redox_activity1.48272981
50MP0002735_abnormal_chemical_nociception1.46619045
51MP0004142_abnormal_muscle_tone1.44862497
52MP0008995_early_reproductive_senescence1.37560766
53MP0003136_yellow_coat_color1.35156363
54MP0003646_muscle_fatigue1.33179086
55MP0008872_abnormal_physiological_respon1.32429120
56MP0002638_abnormal_pupillary_reflex1.32300326
57MP0005451_abnormal_body_composition1.30010224
58MP0004130_abnormal_muscle_cell1.29613787
59MP0005666_abnormal_adipose_tissue1.28440427
60MP0005167_abnormal_blood-brain_barrier1.26207275
61MP0002277_abnormal_respiratory_mucosa1.23814486
62MP0001970_abnormal_pain_threshold1.21131950
63MP0002557_abnormal_social/conspecific_i1.20817630
64MP0002971_abnormal_brown_adipose1.18293143
65MP0004133_heterotaxia1.17813616
66MP0005423_abnormal_somatic_nervous1.16140208
67MP0005647_abnormal_sex_gland1.16085314
68MP0004924_abnormal_behavior1.14162752
69MP0005386_behavior/neurological_phenoty1.14162752
70MP0003880_abnormal_central_pattern1.14052130
71MP0000427_abnormal_hair_cycle1.13667282
72MP0003183_abnormal_peptide_metabolism1.13095356
73MP0000598_abnormal_liver_morphology1.12800436
74MP0002067_abnormal_sensory_capabilities1.11581240
75MP0002733_abnormal_thermal_nociception1.10972767
76MP0003122_maternal_imprinting1.07720664
77MP0001440_abnormal_grooming_behavior1.07299022
78MP0003879_abnormal_hair_cell1.06307088
79MP0003656_abnormal_erythrocyte_physiolo1.06067186
80MP0003011_delayed_dark_adaptation1.05148066
81MP0005636_abnormal_mineral_homeostasis1.04618464
82MP0001661_extended_life_span1.03090759
83MP0005220_abnormal_exocrine_pancreas1.01233465
84MP0002876_abnormal_thyroid_physiology1.00008616
85MP0000026_abnormal_inner_ear0.98297060
86MP0003705_abnormal_hypodermis_morpholog0.98023966
87MP0004381_abnormal_hair_follicle0.97861399
88MP0005253_abnormal_eye_physiology0.96628712
89MP0005058_abnormal_lysosome_morphology0.96020395
90MP0006036_abnormal_mitochondrial_physio0.95905851
91MP0001756_abnormal_urination0.95090894
92MP0000566_synostosis0.92576808
93MP0005334_abnormal_fat_pad0.90764305
94MP0004859_abnormal_synaptic_plasticity0.89157569
95MP0002796_impaired_skin_barrier0.88139976
96MP0001984_abnormal_olfaction0.86697135
97MP0004185_abnormal_adipocyte_glucose0.86686025
98MP0000685_abnormal_immune_system0.85898237
99MP0000955_abnormal_spinal_cord0.84656037
100MP0006276_abnormal_autonomic_nervous0.84612598
101MP0001663_abnormal_digestive_system0.84067502
102MP0005379_endocrine/exocrine_gland_phen0.83583040
103MP0002249_abnormal_larynx_morphology0.83132443
104MP0000631_abnormal_neuroendocrine_gland0.82281983
105MP0004043_abnormal_pH_regulation0.81836723
106MP0000778_abnormal_nervous_system0.81507436
107MP0005376_homeostasis/metabolism_phenot0.81000727
108MP0005535_abnormal_body_temperature0.80986425
109MP0009642_abnormal_blood_homeostasis0.80733460
110MP0001963_abnormal_hearing_physiology0.80092448
111MP0002078_abnormal_glucose_homeostasis0.79572481
112MP0002136_abnormal_kidney_physiology0.79232175
113MP0003137_abnormal_impulse_conducting0.78838162
114MP0004145_abnormal_muscle_electrophysio0.78819709
115MP0000639_abnormal_adrenal_gland0.78178553
116MP0002734_abnormal_mechanical_nocicepti0.77520104
117MP0002254_reproductive_system_inflammat0.77283573
118MP0005645_abnormal_hypothalamus_physiol0.76904459
119MP0003690_abnormal_glial_cell0.75480066
120MP0009115_abnormal_fat_cell0.75252088
121MP0003938_abnormal_ear_development0.74863289
122MP0002882_abnormal_neuron_morphology0.73530443
123MP0005084_abnormal_gallbladder_morpholo0.73193674
124MP0002933_joint_inflammation0.73069324
125MP0009697_abnormal_copulation0.71498075
126MP0002060_abnormal_skin_morphology0.71336437
127MP0005266_abnormal_metabolism0.70530075
128MP0009763_increased_sensitivity_to0.70139487
129MP0005395_other_phenotype0.69177452
130MP0009764_decreased_sensitivity_to0.68347460
131MP0005195_abnormal_posterior_eye0.67318216
132MP0002909_abnormal_adrenal_gland0.66724850
133MP0002168_other_aberrant_phenotype0.65215319
134MP0008469_abnormal_protein_level0.65176931
135MP0008438_abnormal_cutaneous_collagen0.65134767
136MP0005375_adipose_tissue_phenotype0.64857324
137MP0003638_abnormal_response/metabolism_0.64788991
138MP0002970_abnormal_white_adipose0.61513954
139MP0009278_abnormal_bone_marrow0.60340055
140MP0000579_abnormal_nail_morphology0.60142403
141MP0003453_abnormal_keratinocyte_physiol0.59780393
142MP0005408_hypopigmentation0.57702630
143MP0009765_abnormal_xenobiotic_induced0.56704140
144MP0003959_abnormal_lean_body0.54833265
145MP0005448_abnormal_energy_balance0.54776440
146MP0000604_amyloidosis0.54761299
147MP0002928_abnormal_bile_duct0.54512022
148MP0004264_abnormal_extraembryonic_tissu0.53462666
149MP0009053_abnormal_anal_canal0.52664016
150MP0003718_maternal_effect0.51578688
151MP0001765_abnormal_ion_homeostasis0.50391524
152MP0002282_abnormal_trachea_morphology0.49710402
153MP0003953_abnormal_hormone_level0.48405786
154MP0010368_abnormal_lymphatic_system0.46541423
155MP0005075_abnormal_melanosome_morpholog0.46114562
156MP0003724_increased_susceptibility_to0.44606024
157MP0004147_increased_porphyrin_level0.40787317
158MP0008874_decreased_physiological_sensi0.39993045
159MP0002135_abnormal_kidney_morphology0.39565974
160MP0003075_altered_response_to0.39403144
161MP0010030_abnormal_orbit_morphology0.38853490
162MP0000467_abnormal_esophagus_morphology0.37739340
163MP0002295_abnormal_pulmonary_circulatio0.35899054
164MP0001324_abnormal_eye_pigmentation0.35890234
165MP0003172_abnormal_lysosome_physiology0.35844693
166MP0006035_abnormal_mitochondrial_morpho0.35579547
167MP0000538_abnormal_urinary_bladder0.35076759
168MP0000230_abnormal_systemic_arterial0.35018721
169MP0001340_abnormal_eyelid_morphology0.33007197
170MP0000371_diluted_coat_color0.32893454

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.64318464
2Intrahepatic cholestasis (HP:0001406)6.53416774
3Deep venous thrombosis (HP:0002625)5.83981390
4Xanthomatosis (HP:0000991)5.59795205
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.48892447
6Hyperglycinuria (HP:0003108)5.12733988
7Complement deficiency (HP:0004431)5.02958424
8Hypobetalipoproteinemia (HP:0003563)4.95127069
9Prolonged partial thromboplastin time (HP:0003645)4.89122771
10Ketosis (HP:0001946)4.76754279
11Abnormality of serine family amino acid metabolism (HP:0010894)4.76416738
12Abnormality of glycine metabolism (HP:0010895)4.76416738
13Hyperammonemia (HP:0001987)4.71829611
14Hyperglycinemia (HP:0002154)4.66839851
15Hyperlipoproteinemia (HP:0010980)4.51503181
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.50407078
17Attenuation of retinal blood vessels (HP:0007843)4.13709365
18Ketoacidosis (HP:0001993)4.07527990
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.07034964
20Congenital stationary night blindness (HP:0007642)3.98595272
21Concave nail (HP:0001598)3.95919798
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.93109110
23Hypolipoproteinemia (HP:0010981)3.88457256
24Abnormality of fatty-acid metabolism (HP:0004359)3.82779394
25Epidermoid cyst (HP:0200040)3.80185516
26Joint hemorrhage (HP:0005261)3.79527176
27Pancreatic cysts (HP:0001737)3.69067535
28Fat malabsorption (HP:0002630)3.66832191
29Molar tooth sign on MRI (HP:0002419)3.64625390
30Abnormality of midbrain morphology (HP:0002418)3.64625390
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.64094964
32Hypoglycemic coma (HP:0001325)3.63810392
33Ependymoma (HP:0002888)3.62643620
34Abnormality of complement system (HP:0005339)3.62253525
35Abnormality of methionine metabolism (HP:0010901)3.57075348
36Hypoalphalipoproteinemia (HP:0003233)3.55345045
37Gout (HP:0001997)3.45839574
38True hermaphroditism (HP:0010459)3.40210920
39Delayed CNS myelination (HP:0002188)3.38392398
40Pancreatic fibrosis (HP:0100732)3.37489960
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26988617
42Abnormality of the common coagulation pathway (HP:0010990)3.25749606
43Abnormality of the renal cortex (HP:0011035)3.22931741
44Nephronophthisis (HP:0000090)3.20956654
45Abnormality of alanine metabolism (HP:0010916)3.18765021
46Hyperalaninemia (HP:0003348)3.18765021
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.18765021
48Hypochromic microcytic anemia (HP:0004840)3.15377209
49Abnormality of purine metabolism (HP:0004352)3.14342276
50Abnormality of nucleobase metabolism (HP:0010932)3.09896114
51Abnormality of serum amino acid levels (HP:0003112)3.03336688
52Elevated erythrocyte sedimentation rate (HP:0003565)3.02376450
53Abnormality of pyrimidine metabolism (HP:0004353)3.01003791
54Hyperventilation (HP:0002883)3.00598541
55Abnormality of the renal medulla (HP:0100957)2.97148147
56Pendular nystagmus (HP:0012043)2.97026616
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96336443
58Dicarboxylic aciduria (HP:0003215)2.96336443
59Abnormality of the intrinsic pathway (HP:0010989)2.95821897
60Focal motor seizures (HP:0011153)2.95345578
61Myocardial infarction (HP:0001658)2.93579627
62Steatorrhea (HP:0002570)2.88721897
63Lethargy (HP:0001254)2.86517574
64Type II lissencephaly (HP:0007260)2.84458351
65Hypercholesterolemia (HP:0003124)2.83856909
66Cystic liver disease (HP:0006706)2.82586175
67Conjugated hyperbilirubinemia (HP:0002908)2.81796634
68Turricephaly (HP:0000262)2.80456285
69Metabolic acidosis (HP:0001942)2.80304408
70Prolonged QT interval (HP:0001657)2.77929015
71Generalized aminoaciduria (HP:0002909)2.76763956
72Hyperbilirubinemia (HP:0002904)2.68236467
73Hepatocellular carcinoma (HP:0001402)2.64655883
74Chronic hepatic failure (HP:0100626)2.59448172
75Febrile seizures (HP:0002373)2.59331299
76Myositis (HP:0100614)2.58545543
77Birth length less than 3rd percentile (HP:0003561)2.58149048
78Progressive cerebellar ataxia (HP:0002073)2.53317415
79Proximal tubulopathy (HP:0000114)2.51906595
80Increased purine levels (HP:0004368)2.50920808
81Hyperuricemia (HP:0002149)2.50920808
82Focal seizures (HP:0007359)2.49619913
83Atonic seizures (HP:0010819)2.48149539
84Irritability (HP:0000737)2.46967615
85Vascular calcification (HP:0004934)2.46818210
86Malnutrition (HP:0004395)2.45876567
87Inability to walk (HP:0002540)2.44758892
88Agnosia (HP:0010524)2.44380795
89Spastic diplegia (HP:0001264)2.42745444
90Abnormal rod and cone electroretinograms (HP:0008323)2.41809954
91Systemic lupus erythematosus (HP:0002725)2.40543530
92Alkalosis (HP:0001948)2.40528514
93Gait imbalance (HP:0002141)2.39756941
94Vomiting (HP:0002013)2.39459509
95Orchitis (HP:0100796)2.38866556
96Abnormality of proline metabolism (HP:0010907)2.37083495
97Hydroxyprolinuria (HP:0003080)2.37083495
98Astrocytoma (HP:0009592)2.35825413
99Abnormality of the astrocytes (HP:0100707)2.35825413
1003-Methylglutaconic aciduria (HP:0003535)2.35393218
101Skin nodule (HP:0200036)2.32614954
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32244601
103Rickets (HP:0002748)2.31953605
104Enlarged kidneys (HP:0000105)2.31697871
105Keratoconus (HP:0000563)2.30900572
106Increased corneal curvature (HP:0100692)2.30900572
107Cerebral edema (HP:0002181)2.28100167
108Opisthotonus (HP:0002179)2.27861268
109Abnormality of urine glucose concentration (HP:0011016)2.27790353
110Glycosuria (HP:0003076)2.27790353
111Abnormal enzyme/coenzyme activity (HP:0012379)2.24473688
112Pachygyria (HP:0001302)2.23504482
113Occipital encephalocele (HP:0002085)2.23201933
114Constricted visual fields (HP:0001133)2.22297314
115Severe muscular hypotonia (HP:0006829)2.22189497
116Cardiovascular calcification (HP:0011915)2.21707057
117Neonatal onset (HP:0003623)2.21347555
118Pancreatitis (HP:0001733)2.19435880
119Spontaneous abortion (HP:0005268)2.18450994
120Tubular atrophy (HP:0000092)2.17716202
121Polyphagia (HP:0002591)2.17673798
122Optic neuritis (HP:0100653)2.17651752
123Retrobulbar optic neuritis (HP:0100654)2.17651752
124Medial flaring of the eyebrow (HP:0010747)2.17188417
125Nephrogenic diabetes insipidus (HP:0009806)2.14348049
126Lissencephaly (HP:0001339)2.14059426
127Fair hair (HP:0002286)2.13047272
128Amyloidosis (HP:0011034)2.12951211
129Supernumerary spleens (HP:0009799)2.10973347
130Arthropathy (HP:0003040)2.09913537
131Congenital sensorineural hearing impairment (HP:0008527)2.09709227
132Polydipsia (HP:0001959)2.06699717
133Abnormal drinking behavior (HP:0030082)2.06699717
134Patellar aplasia (HP:0006443)2.04714253
135Stomatitis (HP:0010280)2.04552574
136Abnormal hemoglobin (HP:0011902)2.04437196
137Genetic anticipation (HP:0003743)2.04376986
138Recurrent corneal erosions (HP:0000495)2.04262365
139Optic disc pallor (HP:0000543)2.03638774
140Brushfield spots (HP:0001088)2.00884457
141Decreased circulating renin level (HP:0003351)2.00836564
142Abnormality of alkaline phosphatase activity (HP:0004379)2.00371318
143Sensorimotor neuropathy (HP:0007141)2.00057561
144Peritonitis (HP:0002586)1.99955194
145Alopecia of scalp (HP:0002293)1.99833326
146Bile duct proliferation (HP:0001408)1.99226440
147Abnormal biliary tract physiology (HP:0012439)1.99226440
148Neoplasm of the oral cavity (HP:0100649)1.98637077
149Abnormal EKG (HP:0003115)1.97619024
150Congenital primary aphakia (HP:0007707)1.96812070
151Hemorrhage of the eye (HP:0011885)1.95900598
152Abnormal cartilage morphology (HP:0002763)1.95438129
153Hypoglycemic seizures (HP:0002173)1.93122062
154Esophageal varix (HP:0002040)1.92439578
155Tented upper lip vermilion (HP:0010804)1.92016121
156Menorrhagia (HP:0000132)1.91557907
157Late onset (HP:0003584)1.91479099
158Oligomenorrhea (HP:0000876)1.90987986
159Aplasia/Hypoplasia of the patella (HP:0006498)1.90874446
160Cerebral palsy (HP:0100021)1.89443347
161Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89388790
162Generalized hypopigmentation of hair (HP:0011358)1.88475382
163Decreased central vision (HP:0007663)1.87526749
164Cerebellar dysplasia (HP:0007033)1.87438473
165Acute hepatic failure (HP:0006554)1.87296161
166Nephrolithiasis (HP:0000787)1.83603648
167Oligodactyly (hands) (HP:0001180)1.82289070
168Broad-based gait (HP:0002136)1.80636952
169Pancreatic islet-cell hyperplasia (HP:0004510)1.79958282
170Mucopolysacchariduria (HP:0008155)1.79923883
171Urinary glycosaminoglycan excretion (HP:0003541)1.79923883
172Hypertriglyceridemia (HP:0002155)1.79899036
173Congenital hepatic fibrosis (HP:0002612)1.79892935
174Biliary tract neoplasm (HP:0100574)1.79778710
175Absent speech (HP:0001344)1.78968685
176Hemoptysis (HP:0002105)1.78667809
177Morphological abnormality of the pyramidal tract (HP:0002062)1.78431693
178Glioma (HP:0009733)1.77392021
179Abnormal gallbladder morphology (HP:0012437)1.77303551
180Anencephaly (HP:0002323)1.76666646
181Hypoplastic iliac wings (HP:0002866)1.75510598
182Nausea (HP:0002018)1.74797819
183Renal cortical cysts (HP:0000803)1.74507810
184Glomerulonephritis (HP:0000099)1.72821464
185Clumsiness (HP:0002312)1.72264406
186Elevated hepatic transaminases (HP:0002910)1.72161425
187Large for gestational age (HP:0001520)1.71914174
188Mitral stenosis (HP:0001718)1.71711529
189Epileptic encephalopathy (HP:0200134)1.71656400
190Papilledema (HP:0001085)1.71281625
191Tachypnea (HP:0002789)1.71070097
192Abnormality of vitamin metabolism (HP:0100508)1.71013058
193Sleep apnea (HP:0010535)1.70365317
194Stomach cancer (HP:0012126)1.69762842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.59189450
2MAPK154.54415559
3ICK3.99538934
4SIK13.28650515
5MAP3K63.14453166
6PINK12.92796945
7DDR22.88188373
8ERN12.72776902
9FGFR42.58964415
10MARK12.54966993
11MAP4K22.54816118
12DAPK22.43170477
13TNK22.17795496
14MAP3K112.07080026
15MAPK132.05714578
16MAPK111.98673416
17ADRBK21.97190278
18INSRR1.85683383
19OXSR11.82280273
20TRIB31.80369963
21ERBB41.80249449
22WNK41.78697879
23CSK1.76704386
24TYRO31.73137824
25WNK31.70908733
26LATS11.70087762
27PRKD21.66140883
28SIK21.64278576
29MATK1.58987088
30NTRK31.54186339
31FGR1.53966733
32MAP2K61.48889063
33DYRK1B1.46762679
34PDGFRA1.43462468
35ACVR1B1.42091464
36PRKAA21.40235115
37DYRK21.39806949
38GRK11.38608386
39FLT31.36792514
40BMX1.35235522
41GSK3A1.33365104
42NTRK21.32500222
43MST1R1.32298069
44EPHB11.29805604
45STK38L1.26919117
46PAK31.24876447
47CAMK11.20805662
48RIPK41.20426294
49BMPR1B1.19500023
50TAOK31.19416369
51CDK61.16835844
52RIPK11.13286774
53MAP4K11.09095419
54KIT1.08639983
55PAK41.05803606
56STK391.05422068
57MARK21.05244826
58CAMK1D1.02875693
59MAP3K41.01012917
60ADRBK11.00957038
61CASK0.97576269
62PRKAA10.97413859
63MAPK120.92597714
64PTK2B0.90542404
65STK110.89610895
66DAPK10.87228321
67TXK0.86281654
68IRAK40.84869372
69LATS20.83437222
70AKT30.83367931
71DYRK1A0.83072155
72CAMKK20.81180807
73PRKCG0.80755062
74CSNK1G10.79523123
75TGFBR20.79174341
76MAP3K30.79030909
77MET0.76879531
78ABL20.76243611
79PTK20.75246914
80CAMK2G0.73578976
81CAMKK10.73287343
82TIE10.73090382
83PKN10.73011829
84JAK20.72782811
85MAP2K40.71010453
86BLK0.70795344
87ZAP700.68139883
88FGFR20.67420571
89MAPK40.66802235
90CAMK40.66598097
91YES10.65957731
92PIK3CA0.65346787
93SYK0.64081453
94JAK30.63774147
95PKN20.62440164
96TLK10.61911791
97PRKCZ0.61788881
98UHMK10.60736158
99SGK4940.60373655
100SGK2230.60373655
101EPHA30.57977355
102TAOK10.56666244
103TRPM70.56525782
104SGK20.56291424
105IKBKE0.56187826
106MTOR0.55956059
107PIK3CG0.54861557
108MAP2K70.53645979
109DYRK30.53568094
110MAP3K100.53448853
111PRKCQ0.52857360
112FES0.51945295
113NME10.51841598
114PRKACG0.51738587
115RPS6KC10.51483202
116RPS6KL10.51483202
117PRKCE0.51462645
118PTK60.51078744
119LCK0.50923206
120MAPKAPK30.49656185
121MARK30.48914920
122CDK70.48427356
123ERBB20.48082390
124PIM10.47987952
125HCK0.47393955
126MUSK0.47338008
127PIM20.47216306
128NLK0.46869579
129PDK40.46581954
130PDK30.46581954
131TAOK20.45502282
132MAP3K70.44409673
133CSNK1D0.44235440
134RPS6KA60.44090152
135CDK50.43785634
136MAP2K20.43449271
137CAMK2A0.43095058
138MAP2K30.42896648
139RET0.42669603
140CAMK1G0.42203394
141PNCK0.41361673
142EPHA40.41360759
143IRAK10.41287978
144IKBKB0.40121009
145CSF1R0.40066266
146FRK0.38194168
147IRAK20.37521926
148PDPK10.34436695
149EGFR0.34013947
150NEK90.33129580
151TYK20.32908225
152MAPK30.32622427
153STK30.31005997
154PHKG20.30750706
155PHKG10.30750706
156PRKD10.27896498
157INSR0.26280270
158RPS6KA10.26258165
159LYN0.25159156
160STK380.24489467
161ABL10.24202083
162GRK60.23945305
163PDGFRB0.23666554
164PDK20.23382786
165CSNK1G30.23207644
166RPS6KB10.22937536
167HIPK20.21106131

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.09594318
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15640271
3Nicotine addiction_Homo sapiens_hsa050332.97075226
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.89162980
5Nitrogen metabolism_Homo sapiens_hsa009102.86365188
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.77126927
7Fatty acid degradation_Homo sapiens_hsa000712.74306074
8Arginine biosynthesis_Homo sapiens_hsa002202.72065523
9Tryptophan metabolism_Homo sapiens_hsa003802.63992338
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.63284856
11Propanoate metabolism_Homo sapiens_hsa006402.60684591
12Butanoate metabolism_Homo sapiens_hsa006502.53409465
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50886852
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49574391
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.47098812
16Fatty acid metabolism_Homo sapiens_hsa012122.43943036
17Peroxisome_Homo sapiens_hsa041462.30942853
18Morphine addiction_Homo sapiens_hsa050322.26831984
19Complement and coagulation cascades_Homo sapiens_hsa046102.24969009
20PPAR signaling pathway_Homo sapiens_hsa033202.10301587
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09477666
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95374304
23beta-Alanine metabolism_Homo sapiens_hsa004101.89439910
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89056874
25Phototransduction_Homo sapiens_hsa047441.88396968
26GABAergic synapse_Homo sapiens_hsa047271.88320150
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85909957
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81609535
29Fatty acid biosynthesis_Homo sapiens_hsa000611.73874499
30Fatty acid elongation_Homo sapiens_hsa000621.70519849
31Pyruvate metabolism_Homo sapiens_hsa006201.68394826
32Circadian entrainment_Homo sapiens_hsa047131.66768209
33Histidine metabolism_Homo sapiens_hsa003401.64572114
34Ether lipid metabolism_Homo sapiens_hsa005651.63986943
35Chemical carcinogenesis_Homo sapiens_hsa052041.63387370
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63024261
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62103905
38Taste transduction_Homo sapiens_hsa047421.59629881
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57620445
40Regulation of autophagy_Homo sapiens_hsa041401.53840613
41Glutamatergic synapse_Homo sapiens_hsa047241.53325811
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.52126331
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47494087
44Selenocompound metabolism_Homo sapiens_hsa004501.46604059
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45110576
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44256430
47Sulfur metabolism_Homo sapiens_hsa009201.42923594
48Folate biosynthesis_Homo sapiens_hsa007901.41830330
49Retinol metabolism_Homo sapiens_hsa008301.41206928
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.40616218
51Steroid biosynthesis_Homo sapiens_hsa001001.36686456
52Phenylalanine metabolism_Homo sapiens_hsa003601.35434501
53Arginine and proline metabolism_Homo sapiens_hsa003301.31192443
54Biosynthesis of amino acids_Homo sapiens_hsa012301.30374785
55Bile secretion_Homo sapiens_hsa049761.30317040
56Caffeine metabolism_Homo sapiens_hsa002321.30127733
57Staphylococcus aureus infection_Homo sapiens_hsa051501.30085831
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.29376649
59Tyrosine metabolism_Homo sapiens_hsa003501.24359856
60Starch and sucrose metabolism_Homo sapiens_hsa005001.23092412
61Carbon metabolism_Homo sapiens_hsa012001.22631576
62Sulfur relay system_Homo sapiens_hsa041221.21074820
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.19924867
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17954188
65* Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15349834
66Lysine degradation_Homo sapiens_hsa003101.13880083
67Serotonergic synapse_Homo sapiens_hsa047261.13491185
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12924744
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12147327
70Maturity onset diabetes of the young_Homo sapiens_hsa049501.08384598
71ABC transporters_Homo sapiens_hsa020101.06688238
72Insulin secretion_Homo sapiens_hsa049111.04191539
73Fat digestion and absorption_Homo sapiens_hsa049751.02343228
74Cocaine addiction_Homo sapiens_hsa050300.98452642
75Glutathione metabolism_Homo sapiens_hsa004800.98372212
76Glycerolipid metabolism_Homo sapiens_hsa005610.96114115
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.95941763
78Cholinergic synapse_Homo sapiens_hsa047250.94262824
79Vitamin B6 metabolism_Homo sapiens_hsa007500.94175529
80Dopaminergic synapse_Homo sapiens_hsa047280.94004112
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93491903
82Vitamin digestion and absorption_Homo sapiens_hsa049770.91185917
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88269681
84Collecting duct acid secretion_Homo sapiens_hsa049660.86725889
85Olfactory transduction_Homo sapiens_hsa047400.83675486
86Oxidative phosphorylation_Homo sapiens_hsa001900.83072668
87Calcium signaling pathway_Homo sapiens_hsa040200.80246818
88cAMP signaling pathway_Homo sapiens_hsa040240.79015572
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77140913
90Type II diabetes mellitus_Homo sapiens_hsa049300.76377657
91Axon guidance_Homo sapiens_hsa043600.74934315
92Amphetamine addiction_Homo sapiens_hsa050310.74216558
93Dorso-ventral axis formation_Homo sapiens_hsa043200.73292966
94Salivary secretion_Homo sapiens_hsa049700.71586482
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68964651
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68751044
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61883140
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60420436
99Synaptic vesicle cycle_Homo sapiens_hsa047210.60014239
100Osteoclast differentiation_Homo sapiens_hsa043800.59336387
101Ras signaling pathway_Homo sapiens_hsa040140.58527778
102Long-term depression_Homo sapiens_hsa047300.58243110
103Renin secretion_Homo sapiens_hsa049240.53911415
104* Metabolic pathways_Homo sapiens_hsa011000.52782549
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52744349
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51883955
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.48783542
108Pentose phosphate pathway_Homo sapiens_hsa000300.46333001
109Gastric acid secretion_Homo sapiens_hsa049710.45447712
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45228196
111Oxytocin signaling pathway_Homo sapiens_hsa049210.43778633
112Fructose and mannose metabolism_Homo sapiens_hsa000510.43742734
113Parkinsons disease_Homo sapiens_hsa050120.42923514
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42902559
115Cardiac muscle contraction_Homo sapiens_hsa042600.42502069
116One carbon pool by folate_Homo sapiens_hsa006700.42431372
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41728969
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.39922261
119Chemokine signaling pathway_Homo sapiens_hsa040620.36242019
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33249533
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32633937
122Alzheimers disease_Homo sapiens_hsa050100.32394526
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.32379499
124Prion diseases_Homo sapiens_hsa050200.31039253
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30708456
126Galactose metabolism_Homo sapiens_hsa000520.27035640
127AMPK signaling pathway_Homo sapiens_hsa041520.26095310
128Insulin resistance_Homo sapiens_hsa049310.20915898
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.17918088
130Linoleic acid metabolism_Homo sapiens_hsa005910.14391915
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.13582088
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13330602
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09648885
134Glucagon signaling pathway_Homo sapiens_hsa049220.09549742
135Arachidonic acid metabolism_Homo sapiens_hsa005900.05697577
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.01909756
137Protein digestion and absorption_Homo sapiens_hsa049740.01625764
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00317728
139Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1763558
140Hedgehog signaling pathway_Homo sapiens_hsa04340-0.1746106
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1719550
142Notch signaling pathway_Homo sapiens_hsa04330-0.1708693
143Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1575811
144Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1560349
145Mineral absorption_Homo sapiens_hsa04978-0.1397228
146Other glycan degradation_Homo sapiens_hsa00511-0.1331687
147Lysosome_Homo sapiens_hsa04142-0.1231138
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1189653
149Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0813202
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0463094
151Bladder cancer_Homo sapiens_hsa05219-0.0326314
152Circadian rhythm_Homo sapiens_hsa04710-0.0131906
153Insulin signaling pathway_Homo sapiens_hsa04910-0.0023126

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