ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of oxidative stress-induced neuron death (GO:1903203)	7.43217385
2	regulation of DNA endoreduplication (GO:0032875)	6.81000046
3	cullin deneddylation (GO:0010388)	6.32541697
4	protein deneddylation (GO:0000338)	5.93021505
5	positive regulation of response to oxidative stress (GO:1902884)	5.77564420
6	positive regulation of cellular response to oxidative stress (GO:1900409)	5.77564420
7	DNA strand elongation involved in DNA replication (GO:0006271)	5.17306274
8	DNA strand elongation (GO:0022616)	4.90170971
9	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	4.88731004
10	mitochondrial RNA metabolic process (GO:0000959)	4.88368467
11	negative regulation of protein acetylation (GO:1901984)	4.79159035
12	DNA replication checkpoint (GO:0000076)	4.74608957
13	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.52869611
14	DNA replication initiation (GO:0006270)	4.44254026
15	maturation of 5.8S rRNA (GO:0000460)	4.42271452
16	positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)	4.38814810
17	ether lipid metabolic process (GO:0046485)	4.30064253
18	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.20939983
19	gonadal mesoderm development (GO:0007506)	4.14511393
20	mRNA cleavage (GO:0006379)	4.14131092
21	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.82114917
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.81295638
23	DNA deamination (GO:0045006)	3.77020758
24	pseudouridine synthesis (GO:0001522)	3.72931428
25	nucleobase biosynthetic process (GO:0046112)	3.71426701
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.58041457
27	negative regulation of JAK-STAT cascade (GO:0046426)	3.48093012
28	establishment of epithelial cell polarity (GO:0090162)	3.47974320
29	glycerol ether metabolic process (GO:0006662)	3.43851408
30	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.41053073
31	telomere maintenance via semi-conservative replication (GO:0032201)	3.41052968
32	proteasome assembly (GO:0043248)	3.40421567
33	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.39493522
34	rRNA modification (GO:0000154)	3.38292121
35	ribosome assembly (GO:0042255)	3.36408616
36	protein K6-linked ubiquitination (GO:0085020)	3.34891075
37	magnesium ion transport (GO:0015693)	3.31553014
38	postreplication repair (GO:0006301)	3.30589432
39	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.29736713
40	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.27612347
41	protein import into peroxisome matrix (GO:0016558)	3.20714546
42	monoubiquitinated protein deubiquitination (GO:0035520)	3.18739332
43	protein polyglutamylation (GO:0018095)	3.16370527
44	neurotransmitter catabolic process (GO:0042135)	3.15884029
45	ether metabolic process (GO:0018904)	3.14821452
46	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.05682784
47	negative regulation of histone acetylation (GO:0035067)	3.05385793
48	ovulation cycle (GO:0042698)	3.05303569
49	negative regulation of granulocyte differentiation (GO:0030853)	3.03048818
50	DNA unwinding involved in DNA replication (GO:0006268)	2.99347438
51	regulation of histone phosphorylation (GO:0033127)	2.97737378
52	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.96787337
53	regulation of DNA-dependent DNA replication (GO:0090329)	2.96039160
54	tRNA aminoacylation for protein translation (GO:0006418)	2.95566079
55	purine nucleobase biosynthetic process (GO:0009113)	2.94335193
56	rRNA methylation (GO:0031167)	2.92838250
57	positive regulation of ligase activity (GO:0051351)	2.92591790
58	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.89467799
59	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	2.87374110
60	formation of translation preinitiation complex (GO:0001731)	2.87340213
61	actin nucleation (GO:0045010)	2.86962529
62	negative regulation of macrophage differentiation (GO:0045650)	2.86178594
63	nucleoside transmembrane transport (GO:1901642)	2.85384929
64	mitotic nuclear envelope disassembly (GO:0007077)	2.84729848
65	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.82132691
66	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.82132691
67	NADH dehydrogenase complex assembly (GO:0010257)	2.82132691
68	ribonucleoprotein complex disassembly (GO:0032988)	2.81241072
69	telomere maintenance via recombination (GO:0000722)	2.81136741
70	mitotic recombination (GO:0006312)	2.77469573
71	phenylpropanoid metabolic process (GO:0009698)	2.76774166
72	regulation of triglyceride biosynthetic process (GO:0010866)	2.76366869
73	ATP synthesis coupled proton transport (GO:0015986)	2.75691057
74	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.75691057
75	amino acid activation (GO:0043038)	2.75370715
76	tRNA aminoacylation (GO:0043039)	2.75370715
77	protein complex biogenesis (GO:0070271)	2.73117516
78	establishment of integrated proviral latency (GO:0075713)	2.72052029
79	response to growth hormone (GO:0060416)	2.71597651
80	flavonoid metabolic process (GO:0009812)	2.70366150
81	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.70104256
82	glycerophospholipid catabolic process (GO:0046475)	2.66749126
83	histone H2A ubiquitination (GO:0033522)	2.64757282
84	ncRNA 3-end processing (GO:0043628)	2.63873770
85	nuclear pore complex assembly (GO:0051292)	2.63617017
86	nucleobase-containing small molecule interconversion (GO:0015949)	2.62934249
87	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.61519701
88	protein targeting to peroxisome (GO:0006625)	2.59291421
89	establishment of protein localization to peroxisome (GO:0072663)	2.59291421
90	protein localization to peroxisome (GO:0072662)	2.59291421
91	positive regulation of histone H3-K4 methylation (GO:0051571)	2.58768576
92	DNA integrity checkpoint (GO:0031570)	2.58471719
93	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.56893047
94	organelle disassembly (GO:1903008)	2.56437078
95	regulation of translational termination (GO:0006449)	2.55937808
96	phosphatidylethanolamine metabolic process (GO:0046337)	2.54000295
97	kinetochore organization (GO:0051383)	2.53867733
98	peroxisomal transport (GO:0043574)	2.53413958
99	ribosome biogenesis (GO:0042254)	2.53144023
100	DNA replication (GO:0006260)	2.52789207

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.49266292
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.98599733
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.20027741
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.46210374
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.43508936
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.28901400
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.07834964
8	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.97248065
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.89972230
10	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.75669430
11	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.65216244
12	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.61187848
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.59412531
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.59330650
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.52009701
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.48161047
17	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.46011344
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.36773575
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.33142383
20	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.28611253
21	ELK1_19687146_ChIP-ChIP_HELA_Human	2.22525845
22	AR_21909140_ChIP-Seq_LNCAP_Human	2.10126798
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06460196
24	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.06217778
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.03913172
26	ZNF274_21170338_ChIP-Seq_K562_Hela	2.00742717
27	GABP_19822575_ChIP-Seq_HepG2_Human	1.97868569
28	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.92999313
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91506398
30	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.89647519
31	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.85235366
32	ZNF263_19887448_ChIP-Seq_K562_Human	1.81721507
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.81009106
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80021819
35	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.79955503
36	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.79461783
37	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.79263933
38	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.74759583
39	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.66763635
40	XRN2_22483619_ChIP-Seq_HELA_Human	1.65917838
41	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.61984875
42	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.60766428
43	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.58901947
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.58504343
45	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56857075
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.56411191
47	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.53723018
48	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50420689
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.48503578
50	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.43169069
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42175647
52	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.39232423
53	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.37385087
54	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.32953454
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.31345127
56	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.30437615
57	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.27292967
58	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.25835138
59	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.25185226
60	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.23825895
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22929317
62	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.22721025
63	TTF2_22483619_ChIP-Seq_HELA_Human	1.22695515
64	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22187232
65	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.22161588
66	KDM5A_27292631_Chip-Seq_BREAST_Human	1.15021689
67	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.13905072
68	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.12667541
69	NCOR1_26117541_ChIP-Seq_K562_Human	1.12014745
70	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.11672791
71	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.08394222
72	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.06264737
73	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.05807763
74	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02718943
75	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.02089967
76	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.99471481
77	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.97793895
78	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92790569
79	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.91462606
80	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.89900077
81	ELF5_23300383_ChIP-Seq_T47D_Human	0.88678879
82	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.87735669
83	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.83640616
84	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.81892783
85	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.81438794
86	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.80957277
87	IGF1R_20145208_ChIP-Seq_DFB_Human	0.80425195
88	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.80246561
89	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.79732229
90	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.79312315
91	VDR_22108803_ChIP-Seq_LS180_Human	0.79051591
92	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.78078146
93	TFEB_21752829_ChIP-Seq_HELA_Human	0.77714005
94	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.77529021
95	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.76508611
96	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.75286268
97	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.75046078
98	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.74519970
99	CIITA_25753668_ChIP-Seq_RAJI_Human	0.73929891
100	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.73593638

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008007_abnormal_cellular_replicative	7.80449107
2	MP0003806_abnormal_nucleotide_metabolis	6.46315928
3	MP0003315_abnormal_perineum_morphology	3.87577619
4	MP0005360_urolithiasis	3.31321630
5	MP0003786_premature_aging	3.19553426
6	MP0010094_abnormal_chromosome_stability	3.14875319
7	MP0002138_abnormal_hepatobiliary_system	3.09926928
8	MP0009697_abnormal_copulation	3.02579192
9	MP0003950_abnormal_plasma_membrane	2.86005559
10	MP0008058_abnormal_DNA_repair	2.67888568
11	MP0002876_abnormal_thyroid_physiology	2.54867754
12	MP0008995_early_reproductive_senescence	2.53315180
13	MP0003111_abnormal_nucleus_morphology	2.43345577
14	MP0005408_hypopigmentation	2.38310104
15	MP0001873_stomach_inflammation	2.12422652
16	MP0010234_abnormal_vibrissa_follicle	1.90375662
17	MP0000678_abnormal_parathyroid_gland	1.85826377
18	MP0005187_abnormal_penis_morphology	1.81534656
19	MP0003077_abnormal_cell_cycle	1.81513111
20	MP0005451_abnormal_body_composition	1.80270869
21	MP0000613_abnormal_salivary_gland	1.75040191
22	MP0006072_abnormal_retinal_apoptosis	1.66228553
23	MP0003186_abnormal_redox_activity	1.64073255
24	MP0004808_abnormal_hematopoietic_stem	1.63755680
25	MP0003693_abnormal_embryo_hatching	1.63109056
26	MP0010386_abnormal_urinary_bladder	1.62753309
27	MP0002938_white_spotting	1.59188796
28	MP0005058_abnormal_lysosome_morphology	1.56637718
29	MP0005171_absent_coat_pigmentation	1.55990338
30	MP0004043_abnormal_pH_regulation	1.52417898
31	MP0000681_abnormal_thyroid_gland	1.50297585
32	MP0008875_abnormal_xenobiotic_pharmacok	1.48463553
33	MP0002638_abnormal_pupillary_reflex	1.46131915
34	MP0004957_abnormal_blastocyst_morpholog	1.45644860
35	MP0010030_abnormal_orbit_morphology	1.44261534
36	MP0002332_abnormal_exercise_endurance	1.39477877
37	MP0006036_abnormal_mitochondrial_physio	1.32139716
38	MP0001919_abnormal_reproductive_system	1.31172471
39	MP0005389_reproductive_system_phenotype	1.29752007
40	MP0000372_irregular_coat_pigmentation	1.27943589
41	MP0006035_abnormal_mitochondrial_morpho	1.21053908
42	MP0003984_embryonic_growth_retardation	1.20114664
43	MP0003718_maternal_effect	1.19855707
44	MP0002088_abnormal_embryonic_growth/wei	1.19565127
45	MP0005266_abnormal_metabolism	1.15237998
46	MP0001697_abnormal_embryo_size	1.14334090
47	MP0001730_embryonic_growth_arrest	1.11184108
48	MP0000538_abnormal_urinary_bladder	1.08160450
49	MP0001764_abnormal_homeostasis	1.06373107
50	MP0002160_abnormal_reproductive_system	1.04407035
51	MP0000313_abnormal_cell_death	1.04259720
52	MP0001672_abnormal_embryogenesis/_devel	1.04174502
53	MP0005380_embryogenesis_phenotype	1.04174502
54	MP0002249_abnormal_larynx_morphology	1.00251322
55	MP0002132_abnormal_respiratory_system	0.96418665
56	MP0000647_abnormal_sebaceous_gland	0.95754315
57	MP0009250_abnormal_appendicular_skeleto	0.92055163
58	MP0005636_abnormal_mineral_homeostasis	0.91920268
59	MP0001881_abnormal_mammary_gland	0.91568053
60	MP0000358_abnormal_cell_content/	0.90623548
61	MP0001929_abnormal_gametogenesis	0.89414532
62	MP0000350_abnormal_cell_proliferation	0.87323226
63	MP0002210_abnormal_sex_determination	0.82701317
64	MP0005332_abnormal_amino_acid	0.82204295
65	MP0003868_abnormal_feces_composition	0.80184384
66	MP0002796_impaired_skin_barrier	0.79059191
67	MP0001661_extended_life_span	0.76614927
68	MP0001348_abnormal_lacrimal_gland	0.76268751
69	MP0005584_abnormal_enzyme/coenzyme_acti	0.76026089
70	MP0008057_abnormal_DNA_replication	0.75908450
71	MP0003937_abnormal_limbs/digits/tail_de	0.75240284
72	MP0002080_prenatal_lethality	0.73880077
73	MP0002019_abnormal_tumor_incidence	0.72070923
74	MP0000653_abnormal_sex_gland	0.71916459
75	MP0001270_distended_abdomen	0.71282636
76	MP0009765_abnormal_xenobiotic_induced	0.71048841
77	MP0004019_abnormal_vitamin_homeostasis	0.71026188
78	MP0008932_abnormal_embryonic_tissue	0.70728671
79	MP0005220_abnormal_exocrine_pancreas	0.69425844
80	MP0003698_abnormal_male_reproductive	0.69325806
81	MP0003252_abnormal_bile_duct	0.66077592
82	MP0001145_abnormal_male_reproductive	0.64877208
83	MP0005248_abnormal_Harderian_gland	0.62848732
84	MP0000703_abnormal_thymus_morphology	0.61122399
85	MP0000609_abnormal_liver_physiology	0.59857751
86	MP0002254_reproductive_system_inflammat	0.59809421
87	MP0004147_increased_porphyrin_level	0.59308882
88	MP0002085_abnormal_embryonic_tissue	0.58624312
89	MP0002086_abnormal_extraembryonic_tissu	0.58430503
90	MP0005410_abnormal_fertilization	0.57940407
91	MP0003943_abnormal_hepatobiliary_system	0.56380839
92	MP0005501_abnormal_skin_physiology	0.53154665
93	MP0003646_muscle_fatigue	0.52784131
94	MP0003699_abnormal_female_reproductive	0.51662991
95	MP0002909_abnormal_adrenal_gland	0.51661699
96	MP0008775_abnormal_heart_ventricle	0.50947975
97	MP0001243_abnormal_dermal_layer	0.50234668
98	MP0000685_abnormal_immune_system	0.50006115
99	MP0002161_abnormal_fertility/fecundity	0.49250203
100	MP0005319_abnormal_enzyme/_coenzyme	0.48599117

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Delayed CNS myelination (HP:0002188)	7.74518022
2	Abnormality of the phalanges of the 2nd finger (HP:0009541)	4.20717452
3	Fibular aplasia (HP:0002990)	4.05853408
4	Hypoplasia of the uterus (HP:0000013)	3.85024939
5	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.73363153
6	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	3.71966458
7	Dry hair (HP:0011359)	3.58717074
8	Birth length less than 3rd percentile (HP:0003561)	3.44353703
9	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.42907639
10	Autoimmune hemolytic anemia (HP:0001890)	3.41539340
11	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	3.30474476
12	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	3.16367063
13	Congenital, generalized hypertrichosis (HP:0004540)	3.14261624
14	Aplasia involving bones of the extremities (HP:0009825)	3.13182358
15	Aplasia involving bones of the upper limbs (HP:0009823)	3.13182358
16	Aplasia of the phalanges of the hand (HP:0009802)	3.13182358
17	Aplasia/hypoplasia of the uterus (HP:0008684)	3.11462750
18	Ridged nail (HP:0001807)	3.08638746
19	Vacuolated lymphocytes (HP:0001922)	3.00737713
20	Broad face (HP:0000283)	3.00224570
21	Acute encephalopathy (HP:0006846)	2.97135106
22	Premature ovarian failure (HP:0008209)	2.92853924
23	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.84773892
24	Pancreatic cysts (HP:0001737)	2.83101621
25	Abnormality of the fetal cardiovascular system (HP:0010948)	2.74819623
26	Abnormal umbilical cord blood vessels (HP:0011403)	2.74819623
27	Single umbilical artery (HP:0001195)	2.74819623
28	Pancreatic fibrosis (HP:0100732)	2.66894318
29	Supernumerary spleens (HP:0009799)	2.65498175
30	Spondylolisthesis (HP:0003302)	2.63891562
31	Concave nail (HP:0001598)	2.62490046
32	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.62345531
33	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.62345531
34	Acute necrotizing encephalopathy (HP:0006965)	2.60407698
35	Squamous cell carcinoma (HP:0002860)	2.57583955
36	Hypoparathyroidism (HP:0000829)	2.53554197
37	Hyperthyroidism (HP:0000836)	2.52845361
38	Ileus (HP:0002595)	2.52439317
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.51406334
40	Median cleft lip (HP:0000161)	2.49716504
41	Acute lymphatic leukemia (HP:0006721)	2.49470391
42	Neoplasm of the adrenal cortex (HP:0100641)	2.44023745
43	Metaphyseal dysplasia (HP:0100255)	2.43298161
44	Abnormality of the 2nd finger (HP:0004100)	2.43198632
45	Mitochondrial inheritance (HP:0001427)	2.42722850
46	Abnormality of secondary sexual hair (HP:0009888)	2.41684109
47	Abnormality of the axillary hair (HP:0100134)	2.41684109
48	Delayed myelination (HP:0012448)	2.41435979
49	Midline defect of the nose (HP:0004122)	2.38243025
50	Increased CSF lactate (HP:0002490)	2.30397487
51	Sparse lateral eyebrow (HP:0005338)	2.30305678
52	Progressive macrocephaly (HP:0004481)	2.29689312
53	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.29141072
54	Abnormality of pyrimidine metabolism (HP:0004353)	2.28052979
55	Abnormality of chromosome stability (HP:0003220)	2.28043396
56	Abnormality of the pons (HP:0007361)	2.27682090
57	Sparse eyelashes (HP:0000653)	2.26301424
58	Aplasia cutis congenita (HP:0001057)	2.24202835
59	Cerebral hypomyelination (HP:0006808)	2.21962168
60	Short femoral neck (HP:0100864)	2.21798143
61	Hypoplasia of the pons (HP:0012110)	2.21768869
62	Hepatocellular necrosis (HP:0001404)	2.20716459
63	Increased serum lactate (HP:0002151)	2.20203087
64	Abnormality of the middle phalanges of the toes (HP:0010183)	2.19987337
65	Type I transferrin isoform profile (HP:0003642)	2.17716012
66	Abnormality of lateral ventricle (HP:0030047)	2.16876860
67	Abnormality of subcutaneous fat tissue (HP:0001001)	2.12741403
68	Truncus arteriosus (HP:0001660)	2.11538849
69	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.11444357
70	Abnormality of the frontal sinuses (HP:0002687)	2.10611683
71	Patellar aplasia (HP:0006443)	2.06092648
72	Abnormality of the parathyroid morphology (HP:0011766)	2.04389967
73	Abnormality of T cell physiology (HP:0011840)	2.02857057
74	Cutaneous melanoma (HP:0012056)	2.02717469
75	Breast hypoplasia (HP:0003187)	2.02692309
76	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.01197480
77	Epiphyseal stippling (HP:0010655)	1.98254401
78	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.97694692
79	Abnormality of the pupil (HP:0000615)	1.97467621
80	Chromsome breakage (HP:0040012)	1.97392186
81	Aplasia/Hypoplasia of the patella (HP:0006498)	1.96346595
82	Hepatic necrosis (HP:0002605)	1.95843025
83	Tinnitus (HP:0000360)	1.93473832
84	Abnormality of alanine metabolism (HP:0010916)	1.93017320
85	Hyperalaninemia (HP:0003348)	1.93017320
86	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93017320
87	Short tibia (HP:0005736)	1.92090225
88	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.91674247
89	Abnormality of the preputium (HP:0100587)	1.90932001
90	Bone marrow hypocellularity (HP:0005528)	1.90660252
91	Abnormality of the umbilical cord (HP:0010881)	1.89967419
92	Cerebral edema (HP:0002181)	1.89933636
93	Asplenia (HP:0001746)	1.88981792
94	Adactyly (HP:0009776)	1.85944129
95	Fair hair (HP:0002286)	1.85674090
96	Meckel diverticulum (HP:0002245)	1.82038370
97	Abnormality of the renal collecting system (HP:0004742)	1.81931561
98	Lactic acidosis (HP:0003128)	1.80316218
99	Adenoma sebaceum (HP:0009720)	1.80200683
100	Angiofibromas (HP:0010615)	1.80200683

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.50446604
2	ACVR1B	4.35776320
3	PLK2	4.25087305
4	BMPR1B	4.20722429
5	WNK4	3.25926474
6	TRIM28	2.88966288
7	EIF2AK1	2.78712442
8	FRK	2.76129214
9	FLT3	2.65489193
10	SIK3	2.63677031
11	MAPKAPK3	2.52367850
12	PRKCI	2.43013152
13	MAP3K3	2.38248939
14	CDC7	2.37170768
15	EEF2K	2.36060826
16	MST4	2.34648542
17	TGFBR1	2.05827354
18	EIF2AK3	1.86896942
19	SCYL2	1.80170350
20	DAPK1	1.76859272
21	SRPK1	1.71152481
22	TTK	1.66337864
23	STK16	1.58549315
24	EPHA2	1.49682797
25	MAPK13	1.44079148
26	BCR	1.40193976
27	BUB1	1.33413730
28	RPS6KB2	1.31092458
29	PKN2	1.29004769
30	NEK2	1.19676763
31	IRAK3	1.10766324
32	ERBB3	1.00532587
33	CDK3	0.98936423
34	NME1	0.93623445
35	CCNB1	0.93426198
36	NEK1	0.89254876
37	CSNK1E	0.85510401
38	MAPK12	0.84413630
39	PLK1	0.84257967
40	CHEK2	0.82511957
41	CSNK1A1	0.79771049
42	ATR	0.79753488
43	PLK3	0.78877847
44	BRD4	0.77490635
45	PLK4	0.74562199
46	WEE1	0.72822426
47	TRIB3	0.67837997
48	ERBB4	0.66901687
49	AKT2	0.65712057
50	MST1R	0.64738789
51	ZAK	0.60850175
52	AURKB	0.58667292
53	ATM	0.57136558
54	CSNK2A2	0.55333651
55	TRPM7	0.54944348
56	WNK1	0.53391886
57	TEC	0.52208474
58	STK4	0.51278546
59	AURKA	0.49408588
60	CDK2	0.48758668
61	BMPR2	0.48049232
62	PBK	0.46949641
63	ARAF	0.45220284
64	CDK1	0.44185985
65	KSR1	0.43166763
66	BRAF	0.43021184
67	TLK1	0.42748242
68	JAK3	0.42460006
69	CHEK1	0.41471936
70	GRK1	0.41160188
71	LRRK2	0.40980811
72	SGK1	0.39372902
73	NME2	0.38028031
74	MAPKAPK5	0.36295767
75	BRSK1	0.36291994
76	ALK	0.36028647
77	MAPK11	0.32134636
78	FGFR2	0.32036373
79	PRKACB	0.31899115
80	TNK2	0.31280778
81	CSNK2A1	0.30648294
82	PAK4	0.29954919
83	PRKD3	0.29841272
84	TSSK6	0.29293832
85	CSNK1D	0.29260481
86	BRSK2	0.28036237
87	MAP3K13	0.27311767
88	BCKDK	0.25526383
89	PKN1	0.25298911
90	PDK1	0.23058073
91	EIF2AK2	0.21316879
92	PIM2	0.20193936
93	TBK1	0.20192540
94	MAP2K1	0.19628498
95	MAPKAPK2	0.19186132
96	MAP3K8	0.18401152
97	EGFR	0.17889408
98	GSK3B	0.17670111
99	PASK	0.17369730
100	CDK7	0.16875809

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.90382540
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.58040185
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.28396185
4	Drug metabolism - other enzymes_Homo sapiens_hsa00983	3.06957612
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.05667530
6	Proteasome_Homo sapiens_hsa03050	2.83043929
7	Homologous recombination_Homo sapiens_hsa03440	2.69905685
8	Mismatch repair_Homo sapiens_hsa03430	2.61066394
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.53918011
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.41640942
11	One carbon pool by folate_Homo sapiens_hsa00670	2.24360655
12	RNA transport_Homo sapiens_hsa03013	2.15365773
13	Pyrimidine metabolism_Homo sapiens_hsa00240	2.14482836
14	Parkinsons disease_Homo sapiens_hsa05012	2.10577684
15	Other glycan degradation_Homo sapiens_hsa00511	2.03376571
16	Ribosome_Homo sapiens_hsa03010	2.00542970
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.95629791
18	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.89053406
19	Base excision repair_Homo sapiens_hsa03410	1.85784580
20	Spliceosome_Homo sapiens_hsa03040	1.76262868
21	RNA polymerase_Homo sapiens_hsa03020	1.73550277
22	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.73349536
23	RNA degradation_Homo sapiens_hsa03018	1.67760414
24	mRNA surveillance pathway_Homo sapiens_hsa03015	1.57672532
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.53240186
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.43452469
27	Basal transcription factors_Homo sapiens_hsa03022	1.38442116
28	Peroxisome_Homo sapiens_hsa04146	1.35567309
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.33622410
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32873865
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.29728431
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27809124
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.27134031
34	Cell cycle_Homo sapiens_hsa04110	1.26985599
35	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.23228244
36	Glutathione metabolism_Homo sapiens_hsa00480	1.20666005
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.17253232
38	Olfactory transduction_Homo sapiens_hsa04740	1.16863537
39	Sulfur metabolism_Homo sapiens_hsa00920	1.15661809
40	Protein export_Homo sapiens_hsa03060	1.14760976
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.14126194
42	Alzheimers disease_Homo sapiens_hsa05010	1.12978348
43	Galactose metabolism_Homo sapiens_hsa00052	1.12236226
44	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.06419100
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06139690
46	Huntingtons disease_Homo sapiens_hsa05016	1.02653983
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.97673276
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.97087391
49	Purine metabolism_Homo sapiens_hsa00230	0.93073025
50	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92442094
51	Retinol metabolism_Homo sapiens_hsa00830	0.92336019
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.91727621
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89872543
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86640049
55	Propanoate metabolism_Homo sapiens_hsa00640	0.85092016
56	Pentose phosphate pathway_Homo sapiens_hsa00030	0.80779891
57	p53 signaling pathway_Homo sapiens_hsa04115	0.80099198
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.80011755
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78851035
60	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.77526964
61	Sulfur relay system_Homo sapiens_hsa04122	0.76772502
62	Metabolic pathways_Homo sapiens_hsa01100	0.75054169
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.74443150
64	Butanoate metabolism_Homo sapiens_hsa00650	0.74362031
65	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.64434023
66	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.64265628
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.64219660
68	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.62638072
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62048380
70	Caffeine metabolism_Homo sapiens_hsa00232	0.61643873
71	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.61248088
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61224389
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58567451
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57074410
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.47989588
76	Fatty acid degradation_Homo sapiens_hsa00071	0.45556625
77	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.43302889
78	Oocyte meiosis_Homo sapiens_hsa04114	0.42577361
79	Carbon metabolism_Homo sapiens_hsa01200	0.41334270
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40799482
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.40790576
82	Phenylalanine metabolism_Homo sapiens_hsa00360	0.36332325
83	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.35412688
84	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.35246789
85	Asthma_Homo sapiens_hsa05310	0.33839774
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.31895940
87	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.31765815
88	Regulation of autophagy_Homo sapiens_hsa04140	0.31519141
89	Folate biosynthesis_Homo sapiens_hsa00790	0.27384396
90	mTOR signaling pathway_Homo sapiens_hsa04150	0.26014560
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.25588188
92	Mineral absorption_Homo sapiens_hsa04978	0.24700724
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.24489338
94	Small cell lung cancer_Homo sapiens_hsa05222	0.23481865
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.18905568
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.18581206
97	Non-small cell lung cancer_Homo sapiens_hsa05223	0.16168633
98	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.14267460
99	Primary immunodeficiency_Homo sapiens_hsa05340	0.13103648
100	Fatty acid elongation_Homo sapiens_hsa00062	0.12772176

CSAG2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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