ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gonadal mesoderm development (GO:0007506)	7.07963899
2	regulation of translational fidelity (GO:0006450)	5.21201244
3	formation of translation preinitiation complex (GO:0001731)	4.90921491
4	ribosomal small subunit biogenesis (GO:0042274)	4.57391461
5	nuclear pore complex assembly (GO:0051292)	4.31167790
6	ribosome assembly (GO:0042255)	4.27635558
7	DNA replication checkpoint (GO:0000076)	4.01147443
8	DNA strand elongation involved in DNA replication (GO:0006271)	3.98301873
9	ribosomal large subunit biogenesis (GO:0042273)	3.95449671
10	telomere maintenance via semi-conservative replication (GO:0032201)	3.92371803
11	viral transcription (GO:0019083)	3.86649266
12	ribonucleoprotein complex biogenesis (GO:0022613)	3.84993367
13	DNA strand elongation (GO:0022616)	3.83005074
14	negative regulation of protein acetylation (GO:1901984)	3.82961832
15	mitotic nuclear envelope disassembly (GO:0007077)	3.82080968
16	ribosomal small subunit assembly (GO:0000028)	3.76364727
17	translational termination (GO:0006415)	3.72136115
18	nucleobase-containing small molecule interconversion (GO:0015949)	3.68683320
19	nuclear pore organization (GO:0006999)	3.68415405
20	ribosome biogenesis (GO:0042254)	3.66359646
21	mitotic chromosome condensation (GO:0007076)	3.66184621
22	translational initiation (GO:0006413)	3.55676402
23	mitotic sister chromatid segregation (GO:0000070)	3.50673252
24	proline biosynthetic process (GO:0006561)	3.49667756
25	tRNA aminoacylation for protein translation (GO:0006418)	3.46954533
26	nuclear envelope disassembly (GO:0051081)	3.45760190
27	membrane disassembly (GO:0030397)	3.45760190
28	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.44511499
29	COPI coating of Golgi vesicle (GO:0048205)	3.40106808
30	Golgi transport vesicle coating (GO:0048200)	3.40106808
31	translational elongation (GO:0006414)	3.39938522
32	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.38509610
33	cotranslational protein targeting to membrane (GO:0006613)	3.37525970
34	protein targeting to ER (GO:0045047)	3.37488768
35	pore complex assembly (GO:0046931)	3.33621968
36	telomere maintenance via recombination (GO:0000722)	3.32703627
37	amino acid activation (GO:0043038)	3.27657954
38	tRNA aminoacylation (GO:0043039)	3.27657954
39	protein localization to endoplasmic reticulum (GO:0070972)	3.26808767
40	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.24077081
41	regulation of translational elongation (GO:0006448)	3.23463156
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.16431080
43	DNA replication initiation (GO:0006270)	3.15246010
44	regulation of mitotic spindle organization (GO:0060236)	3.12269462
45	folic acid-containing compound biosynthetic process (GO:0009396)	3.11909843
46	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.11802878
47	mitotic recombination (GO:0006312)	3.10340555
48	translation (GO:0006412)	3.09782039
49	DNA topological change (GO:0006265)	3.09347690
50	maturation of SSU-rRNA (GO:0030490)	3.07485427
51	DNA unwinding involved in DNA replication (GO:0006268)	3.06748810
52	sister chromatid segregation (GO:0000819)	3.06428337
53	viral life cycle (GO:0019058)	3.05645811
54	maturation of 5.8S rRNA (GO:0000460)	3.02216138
55	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.01379385
56	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.98615185
57	UMP biosynthetic process (GO:0006222)	2.98615185
58	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.98615185
59	UMP metabolic process (GO:0046049)	2.98615185
60	cellular protein complex disassembly (GO:0043624)	2.97018758
61	viral mRNA export from host cell nucleus (GO:0046784)	2.96985250
62	mRNA cleavage (GO:0006379)	2.95722004
63	positive regulation of ligase activity (GO:0051351)	2.95352691
64	proteasome assembly (GO:0043248)	2.94224575
65	IMP biosynthetic process (GO:0006188)	2.92323177
66	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.91886572
67	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.91620662
68	nucleobase biosynthetic process (GO:0046112)	2.90024984
69	protein complex disassembly (GO:0043241)	2.88628138
70	L-serine metabolic process (GO:0006563)	2.86716783
71	iron ion import (GO:0097286)	2.85191396
72	cellular component biogenesis (GO:0044085)	2.85034435
73	macromolecular complex disassembly (GO:0032984)	2.84376138
74	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.82250393
75	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.79766081
76	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.79169319
77	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.77576689
78	nuclear envelope organization (GO:0006998)	2.77467876
79	protoporphyrinogen IX metabolic process (GO:0046501)	2.77234073
80	DNA catabolic process, exonucleolytic (GO:0000738)	2.75806604
81	regulation of mitochondrial translation (GO:0070129)	2.73631185
82	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.73082400
83	pteridine-containing compound biosynthetic process (GO:0042559)	2.72696925
84	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.72107647
85	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.71798729
86	ATP synthesis coupled proton transport (GO:0015986)	2.71798729
87	rRNA processing (GO:0006364)	2.71627229
88	binding of sperm to zona pellucida (GO:0007339)	2.69809383
89	establishment of integrated proviral latency (GO:0075713)	2.69710059
90	telomere maintenance via telomere lengthening (GO:0010833)	2.69581804
91	chromosome condensation (GO:0030261)	2.68880809
92	purine nucleobase biosynthetic process (GO:0009113)	2.68875542
93	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.68858124
94	mitochondrial DNA metabolic process (GO:0032042)	2.66577707
95	IMP metabolic process (GO:0046040)	2.66072074
96	regulation of ligase activity (GO:0051340)	2.65185698
97	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.64360857
98	rRNA modification (GO:0000154)	2.62775304
99	transcription-coupled nucleotide-excision repair (GO:0006283)	2.62327686
100	chromosome segregation (GO:0007059)	2.61916578

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.20504239
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.76474862
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.49269391
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.33897511
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.29287289
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.10445557
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.04561928
8	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.03008661
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.93425141
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.88008546
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.84498580
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.69520466
13	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.64829767
14	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.58917871
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55597015
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.55442467
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.55285711
18	AR_21909140_ChIP-Seq_LNCAP_Human	2.54923104
19	DCP1A_22483619_ChIP-Seq_HELA_Human	2.41671140
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.41024828
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.18508878
22	GABP_19822575_ChIP-Seq_HepG2_Human	2.13568312
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.00923514
24	TTF2_22483619_ChIP-Seq_HELA_Human	1.96946000
25	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.96627111
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.92608900
27	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.87355429
28	KDM5A_27292631_Chip-Seq_BREAST_Human	1.87128379
29	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.84670677
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.79772442
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.79594486
32	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.77756105
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.77532826
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.77480105
35	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.76331630
36	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.73771888
37	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.73749872
38	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.70069112
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.68170282
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.67235696
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.63837310
42	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.58749058
43	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.55193817
44	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.50284006
45	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.46761276
46	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46398118
47	NCOR1_26117541_ChIP-Seq_K562_Human	1.46113571
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.45228515
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.44619689
50	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.42910808
51	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.42495612
52	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.40063862
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39386494
54	TFEB_21752829_ChIP-Seq_HELA_Human	1.38338582
55	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.37656455
56	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.36807074
57	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.36317001
58	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.36095498
59	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.35415535
60	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.32919248
61	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.32477872
62	CHD1_26751641_Chip-Seq_LNCaP_Human	1.31651229
63	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.30696990
64	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.30257331
65	MYC_22102868_ChIP-Seq_BL_Human	1.28387251
66	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.28123508
67	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.27923076
68	CIITA_25753668_ChIP-Seq_RAJI_Human	1.27315065
69	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.27147514
70	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.26570318
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25473750
72	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24370352
73	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20665617
74	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.19781917
75	ATF3_27146783_Chip-Seq_COLON_Human	1.19133348
76	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.18490999
77	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.17228190
78	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17133703
79	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.16772786
80	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.16373604
81	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.13611134
82	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.11603876
83	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.11055168
84	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.09756188
85	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.08292475
86	RACK7_27058665_Chip-Seq_MCF-7_Human	1.08271411
87	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.04666034
88	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.02495038
89	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00096887
90	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.98489966
91	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.97820486
92	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.96566300
93	* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.95239402
94	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.94711611
95	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.94623763
96	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.94572973
97	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.93783326
98	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.93380003
99	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.93022740
100	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.92381167

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.98377152
2	MP0009697_abnormal_copulation	3.79128179
3	MP0003111_abnormal_nucleus_morphology	3.65117182
4	MP0005451_abnormal_body_composition	3.50800616
5	MP0010094_abnormal_chromosome_stability	3.32010642
6	MP0004957_abnormal_blastocyst_morpholog	3.22533929
7	MP0003693_abnormal_embryo_hatching	3.20253851
8	MP0008058_abnormal_DNA_repair	3.12092104
9	MP0008007_abnormal_cellular_replicative	2.95262314
10	MP0003077_abnormal_cell_cycle	2.82420166
11	MP0005171_absent_coat_pigmentation	2.78933096
12	MP0004858_abnormal_nervous_system	2.68262658
13	MP0003786_premature_aging	2.40013626
14	MP0005408_hypopigmentation	2.27644908
15	MP0008995_early_reproductive_senescence	2.22174876
16	MP0003186_abnormal_redox_activity	2.20636281
17	MP0004233_abnormal_muscle_weight	2.19309845
18	MP0008932_abnormal_embryonic_tissue	2.14975950
19	MP0005360_urolithiasis	2.12012343
20	MP0006036_abnormal_mitochondrial_physio	2.10837131
21	MP0005058_abnormal_lysosome_morphology	1.90338017
22	MP0010234_abnormal_vibrissa_follicle	1.81692645
23	MP0006035_abnormal_mitochondrial_morpho	1.80392520
24	MP0000678_abnormal_parathyroid_gland	1.78393610
25	MP0004147_increased_porphyrin_level	1.76583074
26	MP0002877_abnormal_melanocyte_morpholog	1.73431495
27	MP0003718_maternal_effect	1.63682082
28	MP0000350_abnormal_cell_proliferation	1.59393071
29	MP0001661_extended_life_span	1.59317434
30	MP0003123_paternal_imprinting	1.58512618
31	MP0002938_white_spotting	1.54863597
32	MP0003950_abnormal_plasma_membrane	1.52581599
33	MP0000372_irregular_coat_pigmentation	1.50450539
34	MP0001764_abnormal_homeostasis	1.50444883
35	MP0003705_abnormal_hypodermis_morpholog	1.48763554
36	MP0001697_abnormal_embryo_size	1.47549681
37	MP0008875_abnormal_xenobiotic_pharmacok	1.47450794
38	MP0005410_abnormal_fertilization	1.46494073
39	MP0001730_embryonic_growth_arrest	1.46385381
40	MP0000313_abnormal_cell_death	1.39209042
41	MP0000358_abnormal_cell_content/	1.37379150
42	MP0001881_abnormal_mammary_gland	1.35862063
43	MP0002080_prenatal_lethality	1.34640639
44	MP0003656_abnormal_erythrocyte_physiolo	1.34107942
45	MP0002210_abnormal_sex_determination	1.21003361
46	MP0001929_abnormal_gametogenesis	1.17354562
47	MP0010307_abnormal_tumor_latency	1.17000157
48	MP0005380_embryogenesis_phenotype	1.14711144
49	MP0001672_abnormal_embryogenesis/_devel	1.14711144
50	MP0002249_abnormal_larynx_morphology	1.08997004
51	MP0002086_abnormal_extraembryonic_tissu	1.08268104
52	MP0003984_embryonic_growth_retardation	1.06682133
53	MP0008775_abnormal_heart_ventricle	1.05070345
54	MP0002088_abnormal_embryonic_growth/wei	1.03994942
55	MP0003315_abnormal_perineum_morphology	1.01247197
56	MP0001145_abnormal_male_reproductive	0.97165767
57	MP0000627_abnormal_mammary_gland	0.95510747
58	MP0002019_abnormal_tumor_incidence	0.94947597
59	MP0004084_abnormal_cardiac_muscle	0.94915876
60	MP0001348_abnormal_lacrimal_gland	0.94519847
61	MP0005330_cardiomyopathy	0.93699712
62	MP0004264_abnormal_extraembryonic_tissu	0.91595363
63	MP0003698_abnormal_male_reproductive	0.90985774
64	MP0000609_abnormal_liver_physiology	0.89961092
65	MP0003136_yellow_coat_color	0.89914756
66	MP0004808_abnormal_hematopoietic_stem	0.87981525
67	MP0000537_abnormal_urethra_morphology	0.87593410
68	MP0002160_abnormal_reproductive_system	0.86819606
69	MP0000653_abnormal_sex_gland	0.84887163
70	MP0001873_stomach_inflammation	0.84738366
71	MP0004185_abnormal_adipocyte_glucose	0.83838510
72	MP0001919_abnormal_reproductive_system	0.82854216
73	MP0001727_abnormal_embryo_implantation	0.82579889
74	MP0005076_abnormal_cell_differentiation	0.81406441
75	MP0005501_abnormal_skin_physiology	0.81232299
76	MP0002132_abnormal_respiratory_system	0.81111850
77	MP0000747_muscle_weakness	0.78603336
78	MP0010030_abnormal_orbit_morphology	0.77529381
79	MP0008057_abnormal_DNA_replication	0.76196998
80	MP0003936_abnormal_reproductive_system	0.75382187
81	MP0004197_abnormal_fetal_growth/weight/	0.75257188
82	MP0002161_abnormal_fertility/fecundity	0.74090956
83	MP0005636_abnormal_mineral_homeostasis	0.73909417
84	MP0005384_cellular_phenotype	0.72617167
85	MP0002085_abnormal_embryonic_tissue	0.72185885
86	MP0002075_abnormal_coat/hair_pigmentati	0.70075716
87	MP0001186_pigmentation_phenotype	0.70015056
88	MP0005666_abnormal_adipose_tissue	0.69931408
89	MP0001853_heart_inflammation	0.69877878
90	MP0005319_abnormal_enzyme/_coenzyme	0.69276790
91	MP0000598_abnormal_liver_morphology	0.67639903
92	MP0004019_abnormal_vitamin_homeostasis	0.67048072
93	MP0004036_abnormal_muscle_relaxation	0.66972430
94	MP0003959_abnormal_lean_body	0.64821548
95	MP0000613_abnormal_salivary_gland	0.64729116
96	MP0002084_abnormal_developmental_patter	0.63927374
97	MP0003699_abnormal_female_reproductive	0.63899308
98	MP0004381_abnormal_hair_follicle	0.63782244
99	MP0001545_abnormal_hematopoietic_system	0.62753543
100	MP0005397_hematopoietic_system_phenotyp	0.62753543

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperthyroidism (HP:0000836)	5.06132629
2	Abnormal gallbladder physiology (HP:0012438)	4.76669699
3	Cholecystitis (HP:0001082)	4.76669699
4	Truncus arteriosus (HP:0001660)	3.96536816
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.52624430
6	Chromsome breakage (HP:0040012)	3.40299168
7	Acute encephalopathy (HP:0006846)	3.30981108
8	Upper limb muscle weakness (HP:0003484)	3.29969513
9	Seborrheic dermatitis (HP:0001051)	3.28387100
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.22604116
11	Hypertensive crisis (HP:0100735)	3.17637483
12	Abnormality of glycolysis (HP:0004366)	3.02712297
13	Birth length less than 3rd percentile (HP:0003561)	2.99458990
14	Reticulocytosis (HP:0001923)	2.98866206
15	Abnormality of reticulocytes (HP:0004312)	2.97884913
16	Abnormality of the tricuspid valve (HP:0001702)	2.96448550
17	Reticulocytopenia (HP:0001896)	2.95813293
18	Spastic paraparesis (HP:0002313)	2.92396129
19	Testicular atrophy (HP:0000029)	2.71192697
20	Hypoparathyroidism (HP:0000829)	2.70672750
21	Acute necrotizing encephalopathy (HP:0006965)	2.68481995
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65897593
23	Cholelithiasis (HP:0001081)	2.65868727
24	Pallor (HP:0000980)	2.59684613
25	J-shaped sella turcica (HP:0002680)	2.55391945
26	Abnormality of the preputium (HP:0100587)	2.54966715
27	Abnormal number of erythroid precursors (HP:0012131)	2.50073649
28	Cerebral hypomyelination (HP:0006808)	2.48747628
29	Atelectasis (HP:0100750)	2.47477606
30	Insomnia (HP:0100785)	2.42999676
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.36949641
32	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.36949641
33	Abnormality of cochlea (HP:0000375)	2.34766130
34	Aplasia cutis congenita (HP:0001057)	2.32793564
35	Hepatocellular necrosis (HP:0001404)	2.30448360
36	Increased serum pyruvate (HP:0003542)	2.25577879
37	Bowel incontinence (HP:0002607)	2.25090138
38	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.23938277
39	Morphological abnormality of the inner ear (HP:0011390)	2.23135205
40	Reduced antithrombin III activity (HP:0001976)	2.23034257
41	Spinal cord lesions (HP:0100561)	2.22009691
42	Syringomyelia (HP:0003396)	2.22009691
43	Abnormal gallbladder morphology (HP:0012437)	2.21247858
44	Sparse lateral eyebrow (HP:0005338)	2.20305527
45	Secondary amenorrhea (HP:0000869)	2.20299498
46	Patellar dislocation (HP:0002999)	2.19521486
47	Hand muscle atrophy (HP:0009130)	2.17063956
48	Hyperacusis (HP:0010780)	2.15664469
49	Abnormal large intestine physiology (HP:0012700)	2.15426826
50	Squamous cell carcinoma (HP:0002860)	2.14460478
51	Macrocytic anemia (HP:0001972)	2.14266740
52	Hepatic necrosis (HP:0002605)	2.10732679
53	Male infertility (HP:0003251)	2.06520167
54	Cerebral edema (HP:0002181)	2.06097650
55	Limb hypertonia (HP:0002509)	2.04575315
56	Breast hypoplasia (HP:0003187)	2.03875546
57	Absent thumb (HP:0009777)	2.03558254
58	Entropion (HP:0000621)	2.02256826
59	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.99366415
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.98196793
61	Increased CSF lactate (HP:0002490)	1.96526874
62	Mitochondrial inheritance (HP:0001427)	1.96451724
63	Duplicated collecting system (HP:0000081)	1.95727429
64	Progressive muscle weakness (HP:0003323)	1.95174111
65	Diaphragmatic weakness (HP:0009113)	1.94627651
66	Myelodysplasia (HP:0002863)	1.94372034
67	Progressive macrocephaly (HP:0004481)	1.93935720
68	Neoplasm of head and neck (HP:0012288)	1.92409996
69	Esophageal neoplasm (HP:0100751)	1.92409996
70	Biconcave vertebral bodies (HP:0004586)	1.92330250
71	Abnormal hemoglobin (HP:0011902)	1.91657916
72	Abnormality of pyrimidine metabolism (HP:0004353)	1.91154945
73	Abnormality of the carotid arteries (HP:0005344)	1.90744452
74	Abnormality of the renal collecting system (HP:0004742)	1.88421590
75	Cutaneous melanoma (HP:0012056)	1.88329800
76	Abnormally folded helix (HP:0008544)	1.87771439
77	Ureteral duplication (HP:0000073)	1.86758029
78	Rough bone trabeculation (HP:0100670)	1.86577643
79	Abnormality of the gallbladder (HP:0005264)	1.85859596
80	Lactic acidosis (HP:0003128)	1.85525975
81	Paraparesis (HP:0002385)	1.85384762
82	Ankyloglossia (HP:0010296)	1.83380590
83	Abnormality of DNA repair (HP:0003254)	1.82603026
84	Facial cleft (HP:0002006)	1.81991366
85	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.81929240
86	Abnormality of subcutaneous fat tissue (HP:0001001)	1.81223223
87	Poikiloderma (HP:0001029)	1.80679744
88	Abnormality of chromosome stability (HP:0003220)	1.80189996
89	Generalized aminoaciduria (HP:0002909)	1.79676588
90	Macroorchidism (HP:0000053)	1.79368566
91	Slender long bone (HP:0003100)	1.76072108
92	Polycystic kidney dysplasia (HP:0000113)	1.74646234
93	Increased serum lactate (HP:0002151)	1.74284719
94	Type I transferrin isoform profile (HP:0003642)	1.73948432
95	Cheekbone underdevelopment (HP:0010669)	1.73811892
96	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.73439188
97	Progressive external ophthalmoplegia (HP:0000590)	1.72184125
98	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.71566049
99	Hyperbilirubinemia (HP:0002904)	1.69438751
100	Meckel diverticulum (HP:0002245)	1.68617670

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	4.82112893
2	NME2	4.16164735
3	IRAK3	3.07968113
4	EIF2AK3	2.99763692
5	SIK3	2.71638754
6	EEF2K	2.53565867
7	BUB1	2.45096988
8	TRIM28	2.33373113
9	PRKD3	2.31319140
10	NEK1	2.25152809
11	WEE1	2.22577886
12	ICK	2.19966125
13	TRIB3	2.10049439
14	PBK	2.04696956
15	CDC7	1.98043480
16	MST1R	1.91634274
17	RPS6KB2	1.90890702
18	TTK	1.86519855
19	STK16	1.79358165
20	MST4	1.78922646
21	NEK2	1.66129940
22	WNK4	1.49229774
23	PAK4	1.48153035
24	PKN2	1.47444386
25	VRK2	1.43230564
26	IRAK2	1.43022411
27	EPHA2	1.38188008
28	CCNB1	1.38083704
29	LATS2	1.37389868
30	TSSK6	1.36776642
31	PLK4	1.30822499
32	MAP3K3	1.30524571
33	NME1	1.28571083
34	SMG1	1.25226246
35	BRSK1	1.22086551
36	ILK	1.18097681
37	CHEK2	1.17575661
38	SRPK1	1.16420495
39	AKT3	1.13006549
40	STK39	1.10906878
41	ARAF	1.04930461
42	CDK7	1.03438552
43	LRRK2	1.02926452
44	KSR1	1.01818447
45	MET	1.01247180
46	BRSK2	0.98568739
47	TAOK3	0.98483770
48	MAP3K8	0.95241545
49	MAP3K2	0.91304571
50	BCR	0.89471488
51	AURKA	0.86874110
52	EIF2AK2	0.85460428
53	ERBB4	0.84637507
54	RAF1	0.84568908
55	BRAF	0.83272801
56	PLK1	0.82178289
57	KSR2	0.81087132
58	BMPR2	0.80949432
59	MAP3K12	0.79836375
60	CHEK1	0.78936655
61	SCYL2	0.77808438
62	SIK1	0.77754249
63	AURKB	0.76928554
64	CDK12	0.74992491
65	ATR	0.73631268
66	MAPKAPK3	0.72357012
67	CLK1	0.72274179
68	TAOK2	0.70774427
69	MARK3	0.68307055
70	FLT3	0.67215133
71	CDK8	0.64933406
72	MAP2K3	0.63381906
73	MKNK1	0.62787073
74	AKT2	0.61384011
75	MTOR	0.61349507
76	PAK2	0.56498000
77	CSNK2A2	0.56437448
78	CDK1	0.54656553
79	PIM2	0.53147827
80	CDK3	0.52775699
81	MKNK2	0.52584667
82	ATM	0.51978899
83	CSNK1A1L	0.46610511
84	PRKCI	0.45503469
85	MAPKAPK5	0.45118056
86	CDK2	0.44996846
87	PLK3	0.44631709
88	PTK6	0.43951175
89	PTK2	0.43888861
90	PAK1	0.41828037
91	STK10	0.41290816
92	STK3	0.41054604
93	MOS	0.40888805
94	DMPK	0.39323548
95	NTRK1	0.38957859
96	CSNK2A1	0.37713809
97	CSNK1E	0.36832928
98	PDK2	0.32374091
99	MAP2K6	0.31669210
100	TNIK	0.30736611

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.82240810
2	DNA replication_Homo sapiens_hsa03030	3.66636729
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.57768731
4	Proteasome_Homo sapiens_hsa03050	3.33507258
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.94592988
6	Mismatch repair_Homo sapiens_hsa03430	2.93151160
7	Homologous recombination_Homo sapiens_hsa03440	2.66146544
8	RNA transport_Homo sapiens_hsa03013	2.57038440
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.53953331
10	One carbon pool by folate_Homo sapiens_hsa00670	2.38653058
11	Base excision repair_Homo sapiens_hsa03410	2.21592453
12	Pyrimidine metabolism_Homo sapiens_hsa00240	2.11804978
13	Spliceosome_Homo sapiens_hsa03040	2.10273482
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.00724446
15	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.99065421
16	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.86035272
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.76728403
18	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.76011406
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.72179286
20	RNA polymerase_Homo sapiens_hsa03020	1.71684001
21	Basal transcription factors_Homo sapiens_hsa03022	1.71548433
22	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.70353865
23	Parkinsons disease_Homo sapiens_hsa05012	1.62929644
24	Sulfur relay system_Homo sapiens_hsa04122	1.59755372
25	Other glycan degradation_Homo sapiens_hsa00511	1.58554438
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.57220307
27	mRNA surveillance pathway_Homo sapiens_hsa03015	1.52519917
28	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.46062483
29	Cell cycle_Homo sapiens_hsa04110	1.44814540
30	RNA degradation_Homo sapiens_hsa03018	1.41743346
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.41742529
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.39634535
33	Carbon metabolism_Homo sapiens_hsa01200	1.38930123
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.30739171
35	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.23413116
36	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.18453221
37	Pentose phosphate pathway_Homo sapiens_hsa00030	1.14277236
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.14186636
39	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.14123719
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.13101678
41	Huntingtons disease_Homo sapiens_hsa05016	1.09086392
42	Sulfur metabolism_Homo sapiens_hsa00920	1.05288848
43	Protein export_Homo sapiens_hsa03060	1.05030672
44	Glutathione metabolism_Homo sapiens_hsa00480	1.04043190
45	Non-homologous end-joining_Homo sapiens_hsa03450	1.00621476
46	Alzheimers disease_Homo sapiens_hsa05010	0.98746779
47	Folate biosynthesis_Homo sapiens_hsa00790	0.95657783
48	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.94134101
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.87369781
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.87164460
51	Purine metabolism_Homo sapiens_hsa00230	0.86280425
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.85613355
53	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.83661210
54	p53 signaling pathway_Homo sapiens_hsa04115	0.78566622
55	Tyrosine metabolism_Homo sapiens_hsa00350	0.77685111
56	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76102439
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.75514985
58	Thyroid cancer_Homo sapiens_hsa05216	0.71922801
59	Arginine biosynthesis_Homo sapiens_hsa00220	0.71375547
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.69631686
61	Olfactory transduction_Homo sapiens_hsa04740	0.69402937
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69350242
63	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.68515795
64	Metabolic pathways_Homo sapiens_hsa01100	0.67442035
65	Propanoate metabolism_Homo sapiens_hsa00640	0.67297997
66	Lysine degradation_Homo sapiens_hsa00310	0.61636169
67	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.61574278
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60844255
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59993786
70	Galactose metabolism_Homo sapiens_hsa00052	0.57604211
71	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.56439887
72	Oocyte meiosis_Homo sapiens_hsa04114	0.52547674
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.52243627
74	mTOR signaling pathway_Homo sapiens_hsa04150	0.50730276
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49597730
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49472087
77	Prion diseases_Homo sapiens_hsa05020	0.42246176
78	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.40885479
79	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39536506
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.38062695
81	Fatty acid elongation_Homo sapiens_hsa00062	0.37648145
82	Vibrio cholerae infection_Homo sapiens_hsa05110	0.37566146
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.34567408
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34460894
85	VEGF signaling pathway_Homo sapiens_hsa04370	0.32668217
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.32198722
87	Non-small cell lung cancer_Homo sapiens_hsa05223	0.31140666
88	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.29977437
89	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.27380788
90	Bladder cancer_Homo sapiens_hsa05219	0.27227911
91	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.26871748
92	Viral carcinogenesis_Homo sapiens_hsa05203	0.25921209
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.23784686
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.23278795
95	Herpes simplex infection_Homo sapiens_hsa05168	0.21919926
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.21893438
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.20828020
98	Small cell lung cancer_Homo sapiens_hsa05222	0.19290513
99	Acute myeloid leukemia_Homo sapiens_hsa05221	0.18146345
100	Insulin signaling pathway_Homo sapiens_hsa04910	0.17371757

CSAG3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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