ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	8.93326000
2	regulation of retinoic acid receptor signaling pathway (GO:0048385)	7.71485561
3	synapsis (GO:0007129)	5.65822738
4	maturation of 5.8S rRNA (GO:0000460)	5.18265618
5	negative regulation of protein acetylation (GO:1901984)	4.86768807
6	nuclear pore complex assembly (GO:0051292)	4.63850644
7	DNA replication checkpoint (GO:0000076)	4.10047605
8	proteasome assembly (GO:0043248)	3.99404641
9	histone H2A acetylation (GO:0043968)	3.87136475
10	nuclear pore organization (GO:0006999)	3.85652463
11	mitochondrial DNA replication (GO:0006264)	3.76634296
12	protein deneddylation (GO:0000338)	3.74050228
13	binding of sperm to zona pellucida (GO:0007339)	3.73434353
14	ribosome assembly (GO:0042255)	3.72746417
15	aminoglycoside antibiotic metabolic process (GO:0030647)	3.67877571
16	DNA catabolic process, exonucleolytic (GO:0000738)	3.65068888
17	folic acid metabolic process (GO:0046655)	3.60591327
18	phosphate ion transport (GO:0006817)	3.59509315
19	mitotic nuclear envelope disassembly (GO:0007077)	3.59351334
20	urate metabolic process (GO:0046415)	3.58748929
21	resolution of meiotic recombination intermediates (GO:0000712)	3.57597906
22	rRNA methylation (GO:0031167)	3.57260473
23	negative regulation of histone acetylation (GO:0035067)	3.52145647
24	DNA double-strand break processing (GO:0000729)	3.46414280
25	cullin deneddylation (GO:0010388)	3.41330832
26	DNA methylation involved in gamete generation (GO:0043046)	3.37642734
27	formation of translation preinitiation complex (GO:0001731)	3.37537833
28	telomere maintenance via semi-conservative replication (GO:0032201)	3.36132247
29	rRNA modification (GO:0000154)	3.31921468
30	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.30882243
31	mRNA cleavage (GO:0006379)	3.28206413
32	pore complex assembly (GO:0046931)	3.25486228
33	regulation of translational fidelity (GO:0006450)	3.23224256
34	oxidative demethylation (GO:0070989)	3.17097192
35	nuclear envelope disassembly (GO:0051081)	3.16812269
36	membrane disassembly (GO:0030397)	3.16812269
37	positive regulation of ligase activity (GO:0051351)	3.12208648
38	phosphate ion transmembrane transport (GO:0035435)	3.10201915
39	diterpenoid biosynthetic process (GO:0016102)	3.10077711
40	regulation of RNA export from nucleus (GO:0046831)	3.09927725
41	glycoside metabolic process (GO:0016137)	3.09141029
42	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.05852749
43	meiotic chromosome segregation (GO:0045132)	3.05802092
44	regulation of cellular amino acid metabolic process (GO:0006521)	3.05455371
45	mitochondrial DNA metabolic process (GO:0032042)	3.04546982
46	response to misfolded protein (GO:0051788)	3.03442696
47	ribosomal large subunit biogenesis (GO:0042273)	3.01829300
48	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.01406377
49	male meiosis (GO:0007140)	2.99202326
50	water-soluble vitamin biosynthetic process (GO:0042364)	2.96559016
51	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.95866807
52	DNA replication initiation (GO:0006270)	2.95304316
53	sperm-egg recognition (GO:0035036)	2.93864661
54	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.93549100
55	telomere maintenance via recombination (GO:0000722)	2.91401950
56	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.89921205
57	UMP metabolic process (GO:0046049)	2.89921205
58	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.89921205
59	UMP biosynthetic process (GO:0006222)	2.89921205
60	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.89885818
61	DNA strand elongation involved in DNA replication (GO:0006271)	2.89870215
62	chromosome organization involved in meiosis (GO:0070192)	2.88430338
63	folic acid-containing compound metabolic process (GO:0006760)	2.86706700
64	fusion of sperm to egg plasma membrane (GO:0007342)	2.86323276
65	negative regulation of ligase activity (GO:0051352)	2.84708196
66	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.84708196
67	biotin metabolic process (GO:0006768)	2.83268801
68	lipopolysaccharide biosynthetic process (GO:0009103)	2.82085255
69	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.81864698
70	urea metabolic process (GO:0019627)	2.81838442
71	TOR signaling (GO:0031929)	2.81708438
72	regulation of ligase activity (GO:0051340)	2.81621760
73	ribosome biogenesis (GO:0042254)	2.81162409
74	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.80155950
75	short-chain fatty acid metabolic process (GO:0046459)	2.79979785
76	DNA strand elongation (GO:0022616)	2.79281944
77	transcription from mitochondrial promoter (GO:0006390)	2.77983547
78	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.77736242
79	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.77736242
80	negative regulation of peptidyl-lysine acetylation (GO:2000757)	2.77328254
81	hyperosmotic salinity response (GO:0042538)	2.77225533
82	DNA topological change (GO:0006265)	2.76700120
83	piRNA metabolic process (GO:0034587)	2.71910799
84	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.70312205
85	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.70312205
86	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.70312205
87	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.69373492
88	alkaloid metabolic process (GO:0009820)	2.68519540
89	regulation of response to osmotic stress (GO:0047484)	2.67852588
90	urea cycle (GO:0000050)	2.66681013
91	dopamine transport (GO:0015872)	2.66561171
92	valine metabolic process (GO:0006573)	2.66426556
93	telomere maintenance via telomere lengthening (GO:0010833)	2.66001722
94	retinal metabolic process (GO:0042574)	2.65434875
95	tetrahydrofolate metabolic process (GO:0046653)	2.63424079
96	regulation of mitochondrial translation (GO:0070129)	2.63265965
97	terpenoid biosynthetic process (GO:0016114)	2.62605207
98	glycine metabolic process (GO:0006544)	2.62102539
99	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.61933611
100	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.61933611

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	5.14193132
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.61309022
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.55308439
4	ZNF263_19887448_ChIP-Seq_K562_Human	3.72986695
5	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.52651858
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.46461278
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.45621977
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.34608970
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10488050
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.03457566
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.87003890
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.86791246
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.82175712
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.76775622
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.61801401
16	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.59238115
17	AR_21909140_ChIP-Seq_LNCAP_Human	2.53934764
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.44681268
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.42291669
20	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.40573721
21	VDR_22108803_ChIP-Seq_LS180_Human	2.36602166
22	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.23073170
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.22260429
24	VDR_23849224_ChIP-Seq_CD4+_Human	2.18353787
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.17084896
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99550686
27	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.96583819
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.92319901
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.87626804
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80949406
31	CIITA_25753668_ChIP-Seq_RAJI_Human	1.79242311
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77362730
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.72211423
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.68672116
35	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.67875391
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.65290950
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.64508185
38	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.61970080
39	KDM5A_27292631_Chip-Seq_BREAST_Human	1.61734665
40	XRN2_22483619_ChIP-Seq_HELA_Human	1.60616431
41	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.57596392
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.57508171
43	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.57430026
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.53883215
45	NCOR1_26117541_ChIP-Seq_K562_Human	1.47255302
46	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.44620627
47	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42435927
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.42119460
49	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.42028887
50	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.41929787
51	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.36576934
52	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.36376133
53	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.36001290
54	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.35295344
55	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.35237080
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.32748700
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31391679
58	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.31238399
59	RBPJ_21746931_ChIP-Seq_IB4_Human	1.28466201
60	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.26821075
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25876796
62	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.23719615
63	PHF8_20622853_ChIP-Seq_HELA_Human	1.22451538
64	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.21421655
65	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.17971648
66	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.17773813
67	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.14619751
68	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.13465580
69	ETV1_20927104_ChIP-Seq_GIST48_Human	1.12023854
70	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.10257130
71	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.07084590
72	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.05625443
73	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.02692737
74	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00114644
75	RAC3_21632823_ChIP-Seq_H3396_Human	0.98210973
76	ELF5_23300383_ChIP-Seq_T47D_Human	0.96195985
77	EWS_26573619_Chip-Seq_HEK293_Human	0.96161025
78	TFEB_21752829_ChIP-Seq_HELA_Human	0.93505659
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.92944119
80	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.92789600
81	ER_23166858_ChIP-Seq_MCF-7_Human	0.91294429
82	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90221047
83	NFYB_21822215_ChIP-Seq_K562_Human	0.89868443
84	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.88657918
85	E2F1_20622854_ChIP-Seq_HELA_Human	0.88452642
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.88208241
87	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.88170026
88	P53_21459846_ChIP-Seq_SAOS-2_Human	0.86426241
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.85301717
90	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.83679422
91	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.83156987
92	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.82302875
93	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.81399596
94	NCOR_22424771_ChIP-Seq_293T_Human	0.81118286
95	ZNF274_21170338_ChIP-Seq_K562_Hela	0.81088233
96	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.80557096
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.80149002
98	NFYA_21822215_ChIP-Seq_K562_Human	0.79312540
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.77717876
100	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.77294783

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	4.65739217
2	MP0005360_urolithiasis	4.15977295
3	MP0004147_increased_porphyrin_level	3.91409361
4	MP0002138_abnormal_hepatobiliary_system	3.54861751
5	MP0008058_abnormal_DNA_repair	3.27000903
6	MP0003806_abnormal_nucleotide_metabolis	3.17039317
7	MP0003111_abnormal_nucleus_morphology	2.92543632
8	MP0003786_premature_aging	2.90096577
9	MP0005171_absent_coat_pigmentation	2.78089863
10	MP0005085_abnormal_gallbladder_physiolo	2.74875749
11	MP0008875_abnormal_xenobiotic_pharmacok	2.63960222
12	MP0002139_abnormal_hepatobiliary_system	2.51168604
13	MP0001764_abnormal_homeostasis	2.41914530
14	MP0005410_abnormal_fertilization	2.38422338
15	MP0006036_abnormal_mitochondrial_physio	2.33588848
16	MP0004957_abnormal_blastocyst_morpholog	2.30257787
17	MP0002160_abnormal_reproductive_system	2.29758880
18	MP0008995_early_reproductive_senescence	2.25098948
19	MP0010094_abnormal_chromosome_stability	2.20528410
20	MP0005397_hematopoietic_system_phenotyp	2.06214389
21	MP0001545_abnormal_hematopoietic_system	2.06214389
22	MP0003718_maternal_effect	1.89634704
23	MP0008775_abnormal_heart_ventricle	1.79269011
24	MP0005332_abnormal_amino_acid	1.77995706
25	MP0006035_abnormal_mitochondrial_morpho	1.73948705
26	MP0003077_abnormal_cell_cycle	1.73856925
27	MP0005083_abnormal_biliary_tract	1.73427357
28	MP0005389_reproductive_system_phenotype	1.71459544
29	MP0005365_abnormal_bile_salt	1.70944502
30	MP0001929_abnormal_gametogenesis	1.62900847
31	MP0003868_abnormal_feces_composition	1.62822009
32	MP0008007_abnormal_cellular_replicative	1.61238916
33	MP0002876_abnormal_thyroid_physiology	1.60958352
34	MP0004019_abnormal_vitamin_homeostasis	1.60952706
35	MP0000372_irregular_coat_pigmentation	1.59342645
36	MP0004808_abnormal_hematopoietic_stem	1.55600667
37	MP0003186_abnormal_redox_activity	1.52952264
38	MP0008932_abnormal_embryonic_tissue	1.51760307
39	MP0002938_white_spotting	1.46633599
40	MP0005646_abnormal_pituitary_gland	1.43250335
41	MP0002210_abnormal_sex_determination	1.39621439
42	MP0003195_calcinosis	1.39150105
43	MP0010386_abnormal_urinary_bladder	1.34335066
44	MP0002132_abnormal_respiratory_system	1.31416850
45	MP0010307_abnormal_tumor_latency	1.29379761
46	MP0004084_abnormal_cardiac_muscle	1.25848114
47	MP0000653_abnormal_sex_gland	1.24312784
48	MP0006292_abnormal_olfactory_placode	1.23734702
49	MP0005645_abnormal_hypothalamus_physiol	1.22859926
50	MP0003698_abnormal_male_reproductive	1.20523750
51	MP0000678_abnormal_parathyroid_gland	1.20223777
52	MP0000747_muscle_weakness	1.16852516
53	MP0001661_extended_life_span	1.15246873
54	MP0001145_abnormal_male_reproductive	1.14035706
55	MP0005395_other_phenotype	1.11675944
56	MP0001881_abnormal_mammary_gland	1.10673375
57	MP0005319_abnormal_enzyme/_coenzyme	1.09869094
58	MP0000749_muscle_degeneration	1.07324911
59	MP0004782_abnormal_surfactant_physiolog	1.03146334
60	MP0005636_abnormal_mineral_homeostasis	1.02097255
61	MP0003693_abnormal_embryo_hatching	1.01839525
62	MP0003136_yellow_coat_color	0.94092105
63	MP0008872_abnormal_physiological_respon	0.93832329
64	MP0001697_abnormal_embryo_size	0.93251686
65	MP0003045_fibrosis	0.92850679
66	MP0002161_abnormal_fertility/fecundity	0.91869471
67	MP0001919_abnormal_reproductive_system	0.90735282
68	MP0000681_abnormal_thyroid_gland	0.89481395
69	MP0005647_abnormal_sex_gland	0.89365787
70	MP0003252_abnormal_bile_duct	0.87825570
71	MP0002090_abnormal_vision	0.87175909
72	MP0001666_abnormal_nutrient_absorption	0.85592587
73	MP0000358_abnormal_cell_content/	0.85481066
74	MP0003959_abnormal_lean_body	0.84578259
75	MP0005187_abnormal_penis_morphology	0.83154330
76	MP0009643_abnormal_urine_homeostasis	0.82406843
77	MP0001730_embryonic_growth_arrest	0.81868800
78	MP0009333_abnormal_splenocyte_physiolog	0.81701360
79	MP0005330_cardiomyopathy	0.81018077
80	MP0004215_abnormal_myocardial_fiber	0.80925111
81	MP0000609_abnormal_liver_physiology	0.76473907
82	MP0001119_abnormal_female_reproductive	0.75092376
83	MP0004036_abnormal_muscle_relaxation	0.74981808
84	MP0003950_abnormal_plasma_membrane	0.74244537
85	MP0001968_abnormal_touch/_nociception	0.73017126
86	MP0002080_prenatal_lethality	0.69276607
87	MP0003699_abnormal_female_reproductive	0.68762861
88	MP0000313_abnormal_cell_death	0.67951148
89	MP0001502_abnormal_circadian_rhythm	0.67541959
90	MP0001756_abnormal_urination	0.66862444
91	MP0009780_abnormal_chondrocyte_physiolo	0.66662321
92	MP0000538_abnormal_urinary_bladder	0.66079526
93	MP0004858_abnormal_nervous_system	0.65775200
94	MP0005408_hypopigmentation	0.65157599
95	MP0000598_abnormal_liver_morphology	0.64490949
96	MP0006138_congestive_heart_failure	0.62692530
97	MP0004272_abnormal_basement_membrane	0.60098597
98	MP0003137_abnormal_impulse_conducting	0.59949847
99	MP0001348_abnormal_lacrimal_gland	0.58872049
100	MP0004484_altered_response_of	0.57470321

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Generalized aminoaciduria (HP:0002909)	6.02791032
2	Abnormal gallbladder physiology (HP:0012438)	4.48236286
3	Cholecystitis (HP:0001082)	4.48236286
4	Acute encephalopathy (HP:0006846)	3.64707766
5	Hyperthyroidism (HP:0000836)	3.55410605
6	Pendular nystagmus (HP:0012043)	3.39289492
7	J-shaped sella turcica (HP:0002680)	3.34875865
8	Cerebral edema (HP:0002181)	3.15426795
9	Prolonged partial thromboplastin time (HP:0003645)	3.10406748
10	Abnormality of serum amino acid levels (HP:0003112)	3.00207164
11	Hyperglycinuria (HP:0003108)	2.95434669
12	Abnormality of pyrimidine metabolism (HP:0004353)	2.92152091
13	Testicular atrophy (HP:0000029)	2.83030356
14	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.82707543
15	Abnormality of homocysteine metabolism (HP:0010919)	2.76389135
16	Homocystinuria (HP:0002156)	2.76389135
17	Hypobetalipoproteinemia (HP:0003563)	2.74665796
18	Hyperglycinemia (HP:0002154)	2.69711552
19	Truncus arteriosus (HP:0001660)	2.68022475
20	Acute necrotizing encephalopathy (HP:0006965)	2.66132090
21	Squamous cell carcinoma (HP:0002860)	2.62549012
22	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.62266444
23	Proximal tubulopathy (HP:0000114)	2.59793785
24	Hyperammonemia (HP:0001987)	2.57870015
25	Hepatocellular carcinoma (HP:0001402)	2.56763036
26	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.53188242
27	Submucous cleft hard palate (HP:0000176)	2.46666576
28	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.45502552
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.44876493
30	Birth length less than 3rd percentile (HP:0003561)	2.43099140
31	Cholelithiasis (HP:0001081)	2.42430007
32	Reduced antithrombin III activity (HP:0001976)	2.39203687
33	Abnormality of methionine metabolism (HP:0010901)	2.38964914
34	Lethargy (HP:0001254)	2.36044046
35	Increased CSF lactate (HP:0002490)	2.32122850
36	Deep venous thrombosis (HP:0002625)	2.31909451
37	Abnormality of DNA repair (HP:0003254)	2.31720921
38	Entropion (HP:0000621)	2.30408280
39	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.25665041
40	Abnormality of serine family amino acid metabolism (HP:0010894)	2.25068779
41	Abnormality of glycine metabolism (HP:0010895)	2.25068779
42	Upper limb muscle weakness (HP:0003484)	2.23875008
43	Hepatic necrosis (HP:0002605)	2.23397133
44	Abnormality of placental membranes (HP:0011409)	2.23051008
45	Amniotic constriction ring (HP:0009775)	2.23051008
46	Progressive macrocephaly (HP:0004481)	2.23002116
47	Abnormality of dental color (HP:0011073)	2.22656474
48	Abnormality of urine glucose concentration (HP:0011016)	2.21618485
49	Glycosuria (HP:0003076)	2.21618485
50	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.18523521
51	Seborrheic dermatitis (HP:0001051)	2.18439683
52	Epiphyseal stippling (HP:0010655)	2.18243738
53	Mitochondrial inheritance (HP:0001427)	2.18146387
54	Abnormality of alanine metabolism (HP:0010916)	2.18088730
55	Hyperalaninemia (HP:0003348)	2.18088730
56	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18088730
57	Abnormality of the renal collecting system (HP:0004742)	2.11550413
58	Abnormal gallbladder morphology (HP:0012437)	2.11087455
59	Poikiloderma (HP:0001029)	2.10934920
60	Chromsome breakage (HP:0040012)	2.09365966
61	Reticulocytosis (HP:0001923)	2.08827994
62	Abnormality of reticulocytes (HP:0004312)	2.07757980
63	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05760626
64	Reticulocytopenia (HP:0001896)	2.05499061
65	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.05186656
66	Cerebral palsy (HP:0100021)	2.03782258
67	Abnormality of the preputium (HP:0100587)	2.00200129
68	Hepatocellular necrosis (HP:0001404)	1.99644210
69	Abnormality of cochlea (HP:0000375)	1.98322258
70	Increased serum ferritin (HP:0003281)	1.96820554
71	Rough bone trabeculation (HP:0100670)	1.96464120
72	Duodenal stenosis (HP:0100867)	1.95223224
73	Small intestinal stenosis (HP:0012848)	1.95223224
74	Metabolic acidosis (HP:0001942)	1.94933417
75	Secondary amenorrhea (HP:0000869)	1.94679944
76	Intrahepatic cholestasis (HP:0001406)	1.93830405
77	Abnormal trabecular bone morphology (HP:0100671)	1.90136820
78	Abnormality of the carotid arteries (HP:0005344)	1.89831426
79	Hypoparathyroidism (HP:0000829)	1.88045190
80	Hyperbilirubinemia (HP:0002904)	1.87689356
81	Congenital stationary night blindness (HP:0007642)	1.86593278
82	Lactic acidosis (HP:0003128)	1.86571069
83	Myelodysplasia (HP:0002863)	1.86541186
84	Median cleft lip (HP:0000161)	1.85535868
85	Premature ovarian failure (HP:0008209)	1.83135235
86	Hypothermia (HP:0002045)	1.82614813
87	Abnormal epiphyseal ossification (HP:0010656)	1.82421646
88	Long clavicles (HP:0000890)	1.80868032
89	Morphological abnormality of the inner ear (HP:0011390)	1.77650636
90	Ankyloglossia (HP:0010296)	1.77570769
91	Abnormality of transition element cation homeostasis (HP:0011030)	1.76782604
92	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.76704104
93	Absent epiphyses (HP:0010577)	1.76704104
94	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.74768927
95	Popliteal pterygium (HP:0009756)	1.73485277
96	Duplicated collecting system (HP:0000081)	1.71969546
97	Abnormality of glycolysis (HP:0004366)	1.71895167
98	Increased serum lactate (HP:0002151)	1.71700745
99	Poor head control (HP:0002421)	1.71310642
100	Small hand (HP:0200055)	1.69508365

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	5.70202534
2	EIF2AK1	5.11857743
3	SIK3	4.83530135
4	EIF2AK3	4.57778508
5	BCR	3.58597729
6	BUB1	3.51583255
7	STK39	2.77412618
8	STK16	2.71281406
9	PLK4	2.42763278
10	MKNK2	2.17506981
11	MST1R	2.07129409
12	ACVR1B	2.06353646
13	TLK1	1.90107096
14	BRSK2	1.86404180
15	MKNK1	1.78513029
16	PDK2	1.78293185
17	SRPK1	1.72728364
18	WEE1	1.53812787
19	OXSR1	1.53306103
20	FRK	1.49725925
21	CCNB1	1.45308487
22	NME2	1.44996141
23	NEK1	1.44025252
24	KSR1	1.39617814
25	ERBB3	1.32446740
26	PBK	1.30498448
27	EIF2AK2	1.28215356
28	TTK	1.21789456
29	WNK4	1.21624110
30	BRSK1	1.11569716
31	CLK1	1.10646931
32	NME1	1.05736483
33	CDC7	1.01218130
34	PLK1	0.86533297
35	STK3	0.83003145
36	PLK3	0.82732121
37	AURKA	0.82447759
38	RPS6KB2	0.82437437
39	MST4	0.82367048
40	MUSK	0.79220449
41	RIPK4	0.77967965
42	PLK2	0.77239409
43	NUAK1	0.76028306
44	NTRK3	0.75512264
45	DDR2	0.73727899
46	MAP3K3	0.68112219
47	AURKB	0.65832935
48	RPS6KA5	0.63619812
49	NEK2	0.63511149
50	MAP3K2	0.62936132
51	ADRBK2	0.61462799
52	CSNK1A1L	0.60696743
53	CHEK2	0.60090948
54	CSNK1G3	0.59488536
55	TSSK6	0.58573000
56	PTK6	0.57792916
57	RAF1	0.56290475
58	CDK7	0.55698853
59	CHEK1	0.54321571
60	MINK1	0.53912228
61	MARK3	0.53782561
62	CSNK2A1	0.51651952
63	MET	0.49821020
64	BMPR2	0.49788443
65	CSNK2A2	0.47362696
66	PINK1	0.44971713
67	PAK4	0.43163926
68	GRK5	0.42399447
69	VRK2	0.42172058
70	ATR	0.41227445
71	CDK2	0.41183192
72	PKN2	0.41083949
73	CSNK1A1	0.41075421
74	CDK1	0.40822132
75	CSNK1G2	0.37595749
76	ILK	0.37412601
77	ATM	0.36278472
78	MAPK15	0.35480809
79	TNIK	0.35151040
80	MAP2K1	0.34989289
81	LATS2	0.33916969
82	ALK	0.30160371
83	WNK1	0.29890656
84	CSNK1E	0.29355200
85	LRRK2	0.29261691
86	CSNK1G1	0.27571695
87	FER	0.27246964
88	PRKCG	0.27221775
89	PAK1	0.26998472
90	TAOK3	0.25729869
91	ERBB4	0.25246891
92	PRKACG	0.24604880
93	KSR2	0.24176574
94	MAP3K8	0.23828779
95	STK10	0.23603718
96	PRKACB	0.22651161
97	INSRR	0.21658441
98	AKT2	0.21509188
99	PHKG2	0.20809287
100	PHKG1	0.20809287

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.81147202
2	One carbon pool by folate_Homo sapiens_hsa00670	2.72455639
3	DNA replication_Homo sapiens_hsa03030	2.46117112
4	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.40398161
5	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.36480107
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.25292537
7	Mismatch repair_Homo sapiens_hsa03430	2.21803971
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.19997435
9	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.15037948
10	Sulfur metabolism_Homo sapiens_hsa00920	2.04713789
11	Propanoate metabolism_Homo sapiens_hsa00640	2.03647052
12	Homologous recombination_Homo sapiens_hsa03440	2.02117689
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.01366512
14	Retinol metabolism_Homo sapiens_hsa00830	1.96902354
15	RNA transport_Homo sapiens_hsa03013	1.95705747
16	Sulfur relay system_Homo sapiens_hsa04122	1.92565518
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.83085619
18	Spliceosome_Homo sapiens_hsa03040	1.77989504
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.73410872
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.72670380
21	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.72591552
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.69638965
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.68763328
24	Basal transcription factors_Homo sapiens_hsa03022	1.66716359
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.66234653
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.65091476
27	Ribosome_Homo sapiens_hsa03010	1.62953568
28	RNA polymerase_Homo sapiens_hsa03020	1.58382727
29	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.55600103
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.55352995
31	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.53343286
32	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.44691872
33	Carbon metabolism_Homo sapiens_hsa01200	1.43155031
34	RNA degradation_Homo sapiens_hsa03018	1.33493236
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.33100296
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30527716
37	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.29788601
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.29357454
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.25460261
40	mRNA surveillance pathway_Homo sapiens_hsa03015	1.20862601
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20448788
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.18834009
43	Butanoate metabolism_Homo sapiens_hsa00650	1.16650650
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14122541
45	Oxidative phosphorylation_Homo sapiens_hsa00190	1.12888840
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.10331570
47	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.09906924
48	Base excision repair_Homo sapiens_hsa03410	1.07999775
49	Tyrosine metabolism_Homo sapiens_hsa00350	1.05335791
50	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.04496980
51	Linoleic acid metabolism_Homo sapiens_hsa00591	1.04429424
52	Parkinsons disease_Homo sapiens_hsa05012	1.01023378
53	Other glycan degradation_Homo sapiens_hsa00511	0.98067012
54	Phenylalanine metabolism_Homo sapiens_hsa00360	0.91711250
55	Complement and coagulation cascades_Homo sapiens_hsa04610	0.90787092
56	Phototransduction_Homo sapiens_hsa04744	0.87177771
57	Asthma_Homo sapiens_hsa05310	0.86382866
58	Glutathione metabolism_Homo sapiens_hsa00480	0.83956407
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.82784392
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82600196
61	Metabolic pathways_Homo sapiens_hsa01100	0.82131546
62	Cell cycle_Homo sapiens_hsa04110	0.81775170
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81610742
64	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.78950907
65	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.78322926
66	Renin-angiotensin system_Homo sapiens_hsa04614	0.76196002
67	Pentose phosphate pathway_Homo sapiens_hsa00030	0.75891351
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.75022733
69	Protein export_Homo sapiens_hsa03060	0.74867595
70	Fatty acid elongation_Homo sapiens_hsa00062	0.72950626
71	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.72890464
72	Purine metabolism_Homo sapiens_hsa00230	0.71763805
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.69810802
74	Peroxisome_Homo sapiens_hsa04146	0.64132115
75	Folate biosynthesis_Homo sapiens_hsa00790	0.64050138
76	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.60486324
77	Huntingtons disease_Homo sapiens_hsa05016	0.59171454
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58296337
79	Taste transduction_Homo sapiens_hsa04742	0.57626404
80	Oocyte meiosis_Homo sapiens_hsa04114	0.55765401
81	Caffeine metabolism_Homo sapiens_hsa00232	0.54781654
82	Fatty acid degradation_Homo sapiens_hsa00071	0.54659162
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54490502
84	Alzheimers disease_Homo sapiens_hsa05010	0.51249105
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50781134
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.50604758
87	Bile secretion_Homo sapiens_hsa04976	0.48464819
88	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.47901930
89	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.47438575
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43124516
91	p53 signaling pathway_Homo sapiens_hsa04115	0.37893352
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.37568822
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36932585
94	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36566220
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32623354
96	Lysine degradation_Homo sapiens_hsa00310	0.31449051
97	ABC transporters_Homo sapiens_hsa02010	0.31231927
98	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.30414975
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30079836
100	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.25577420

CSAG4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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