

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.61527658 |
| 2 | vocalization behavior (GO:0071625) | 5.39431124 |
| 3 | regulation of actin filament-based movement (GO:1903115) | 5.29786667 |
| 4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.29675255 |
| 5 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 5.20111066 |
| 6 | locomotory exploration behavior (GO:0035641) | 5.17404849 |
| 7 | cardiac muscle hypertrophy (GO:0003300) | 5.16961708 |
| 8 | cardiac muscle contraction (GO:0060048) | 5.15077517 |
| 9 | synaptic vesicle maturation (GO:0016188) | 5.14821988 |
| 10 | synaptic vesicle exocytosis (GO:0016079) | 5.13948532 |
| 11 | sarcomere organization (GO:0045214) | 5.05888492 |
| 12 | cardiac myofibril assembly (GO:0055003) | 4.98633114 |
| 13 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.97447875 |
| 14 | striated muscle hypertrophy (GO:0014897) | 4.88010796 |
| 15 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.85919062 |
| 16 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.74297678 |
| 17 | cardiac muscle adaptation (GO:0014887) | 4.70124775 |
| 18 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 4.70124775 |
| 19 | muscle hypertrophy in response to stress (GO:0003299) | 4.70124775 |
| 20 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.67326068 |
| 21 | regulation of cardiac muscle cell contraction (GO:0086004) | 4.63825814 |
| 22 | neuron cell-cell adhesion (GO:0007158) | 4.62890087 |
| 23 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 4.59237001 |
| 24 | regulation of cell communication by electrical coupling (GO:0010649) | 4.58341647 |
| 25 | protein localization to synapse (GO:0035418) | 4.53742518 |
| 26 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.48272892 |
| 27 | glutamate secretion (GO:0014047) | 4.44542841 |
| 28 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 4.37652143 |
| 29 | regulation of synapse structural plasticity (GO:0051823) | 4.32918998 |
| 30 | gamma-aminobutyric acid transport (GO:0015812) | 4.32336161 |
| 31 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.32082916 |
| 32 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.28700091 |
| 33 | muscle hypertrophy (GO:0014896) | 4.25609890 |
| 34 | cellular potassium ion homeostasis (GO:0030007) | 4.24921882 |
| 35 | detection of calcium ion (GO:0005513) | 4.21137775 |
| 36 | myofibril assembly (GO:0030239) | 4.19092989 |
| 37 | layer formation in cerebral cortex (GO:0021819) | 4.18056501 |
| 38 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 4.17809729 |
| 39 | regulation of synaptic vesicle transport (GO:1902803) | 4.17076963 |
| 40 | neurotransmitter secretion (GO:0007269) | 4.16213613 |
| 41 | exploration behavior (GO:0035640) | 4.14056357 |
| 42 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 4.00108890 |
| 43 | cell communication by electrical coupling (GO:0010644) | 3.96214081 |
| 44 | synaptic transmission, glutamatergic (GO:0035249) | 3.95255539 |
| 45 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.93872947 |
| 46 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.93508339 |
| 47 | sodium ion export (GO:0071436) | 3.92631795 |
| 48 | glutamate receptor signaling pathway (GO:0007215) | 3.90995762 |
| 49 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 3.90046904 |
| 50 | dendritic spine morphogenesis (GO:0060997) | 3.87391563 |
| 51 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.87269271 |
| 52 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.85813170 |
| 53 | neuronal action potential propagation (GO:0019227) | 3.85643436 |
| 54 | regulation of cardioblast differentiation (GO:0051890) | 3.79079942 |
| 55 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.78286935 |
| 56 | proline transport (GO:0015824) | 3.77409400 |
| 57 | actin-myosin filament sliding (GO:0033275) | 3.75384289 |
| 58 | muscle filament sliding (GO:0030049) | 3.75384289 |
| 59 | adult heart development (GO:0007512) | 3.73511339 |
| 60 | response to pheromone (GO:0019236) | 3.72915062 |
| 61 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.72414873 |
| 62 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.71072500 |
| 63 | postsynaptic membrane organization (GO:0001941) | 3.70369491 |
| 64 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.68197640 |
| 65 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.67829916 |
| 66 | regulation of the force of heart contraction (GO:0002026) | 3.66276399 |
| 67 | regulation of striated muscle contraction (GO:0006942) | 3.62552878 |
| 68 | neuron-neuron synaptic transmission (GO:0007270) | 3.62271442 |
| 69 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.60725264 |
| 70 | regulation of cardiac muscle contraction (GO:0055117) | 3.59920303 |
| 71 | synaptic vesicle endocytosis (GO:0048488) | 3.55831126 |
| 72 | cellular response to epinephrine stimulus (GO:0071872) | 3.54870939 |
| 73 | cerebellar granule cell differentiation (GO:0021707) | 3.54615281 |
| 74 | positive regulation of synapse maturation (GO:0090129) | 3.54335118 |
| 75 | regulation of relaxation of muscle (GO:1901077) | 3.54095599 |
| 76 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.53678287 |
| 77 | neurotransmitter transport (GO:0006836) | 3.51804443 |
| 78 | striated muscle contraction (GO:0006941) | 3.51775578 |
| 79 | cardiac muscle cell development (GO:0055013) | 3.49799431 |
| 80 | long-term memory (GO:0007616) | 3.49081423 |
| 81 | positive regulation of action potential (GO:0045760) | 3.48389127 |
| 82 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.47577610 |
| 83 | transmission of nerve impulse (GO:0019226) | 3.45774709 |
| 84 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.45262106 |
| 85 | dendrite morphogenesis (GO:0048813) | 3.43231553 |
| 86 | neuron recognition (GO:0008038) | 3.43050189 |
| 87 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.41847188 |
| 88 | response to auditory stimulus (GO:0010996) | 3.40285406 |
| 89 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.38367275 |
| 90 | regulation of heart rate (GO:0002027) | 3.38242876 |
| 91 | cell migration in hindbrain (GO:0021535) | 3.34812635 |
| 92 | auditory behavior (GO:0031223) | 3.34784105 |
| 93 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.30608847 |
| 94 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.25732798 |
| 95 | cardiac cell development (GO:0055006) | 3.25084932 |
| 96 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.24665841 |
| 97 | actomyosin structure organization (GO:0031032) | 3.24263725 |
| 98 | response to epinephrine (GO:0071871) | 3.24097949 |
| 99 | cardiac ventricle formation (GO:0003211) | 3.23878803 |
| 100 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.22200221 |
| 101 | potassium ion import (GO:0010107) | 3.21585777 |
| 102 | heart process (GO:0003015) | 3.18558863 |
| 103 | heart contraction (GO:0060047) | 3.18558863 |
| 104 | neuromuscular process controlling balance (GO:0050885) | 3.18135330 |
| 105 | regulation of neurotransmitter levels (GO:0001505) | 3.16775108 |
| 106 | cardiac chamber formation (GO:0003207) | 3.16769911 |
| 107 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.16619767 |
| 108 | regulation of neurotransmitter secretion (GO:0046928) | 3.16261515 |
| 109 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.15179809 |
| 110 | positive regulation of membrane potential (GO:0045838) | 3.14913423 |
| 111 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.14171538 |
| 112 | regulation of heart contraction (GO:0008016) | 3.12965940 |
| 113 | axonal fasciculation (GO:0007413) | 3.12809234 |
| 114 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.12575768 |
| 115 | potassium ion homeostasis (GO:0055075) | 3.12503498 |
| 116 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 3.11964419 |
| 117 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.11433984 |
| 118 | regulation of postsynaptic membrane potential (GO:0060078) | 3.10776857 |
| 119 | regulation of vesicle fusion (GO:0031338) | 3.10737579 |
| 120 | muscle tissue morphogenesis (GO:0060415) | 3.10555251 |
| 121 | presynaptic membrane assembly (GO:0097105) | 3.08605457 |
| 122 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.08262479 |
| 123 | actin-mediated cell contraction (GO:0070252) | 3.08033355 |
| 124 | glycine transport (GO:0015816) | 3.07843272 |
| 125 | innervation (GO:0060384) | 3.06138303 |
| 126 | cardiac conduction (GO:0061337) | 3.05854068 |
| 127 | positive regulation of synapse assembly (GO:0051965) | 3.05809834 |
| 128 | L-amino acid import (GO:0043092) | 3.05661431 |
| 129 | membrane hyperpolarization (GO:0060081) | 3.05547387 |
| 130 | synapse assembly (GO:0007416) | 3.05134032 |
| 131 | membrane depolarization during action potential (GO:0086010) | 3.04604954 |
| 132 | cardiac muscle cell action potential (GO:0086001) | 3.04473941 |
| 133 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.02729804 |
| 134 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.02461655 |
| 135 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.01928491 |
| 136 | regulation of synapse maturation (GO:0090128) | 3.00087356 |
| 137 | membrane repolarization (GO:0086009) | 2.98420825 |
| 138 | acidic amino acid transport (GO:0015800) | 2.98000030 |
| 139 | presynaptic membrane organization (GO:0097090) | 2.96547401 |
| 140 | long-term synaptic potentiation (GO:0060291) | 2.94035742 |
| 141 | regulation of neurotransmitter transport (GO:0051588) | 2.93934777 |
| 142 | cellular response to monoamine stimulus (GO:0071868) | 2.92809148 |
| 143 | cellular response to catecholamine stimulus (GO:0071870) | 2.92809148 |
| 144 | positive regulation of heart rate (GO:0010460) | 2.92746496 |
| 145 | regulation of synaptic plasticity (GO:0048167) | 2.92707615 |
| 146 | regulation of respiratory system process (GO:0044065) | 2.90191751 |
| 147 | activation of protein kinase A activity (GO:0034199) | 2.89587767 |
| 148 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.88770521 |
| 149 | membrane depolarization (GO:0051899) | 2.87589595 |
| 150 | cell communication involved in cardiac conduction (GO:0086065) | 2.87472783 |
| 151 | adult walking behavior (GO:0007628) | 2.87103622 |
| 152 | cellular sodium ion homeostasis (GO:0006883) | 2.86600311 |
| 153 | neuromuscular process controlling posture (GO:0050884) | 2.85285848 |
| 154 | regulation of membrane repolarization (GO:0060306) | 2.84640509 |
| 155 | synapse organization (GO:0050808) | 2.84161231 |
| 156 | striated muscle adaptation (GO:0014888) | 2.83600779 |
| 157 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 2.83124681 |
| 158 | positive regulation of dendritic spine development (GO:0060999) | 2.82243152 |
| 159 | neuronal ion channel clustering (GO:0045161) | 2.82100061 |
| 160 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.82032459 |
| 161 | positive regulation of sodium ion transport (GO:0010765) | 2.75903547 |
| 162 | regulation of calcium ion transmembrane transport (GO:1903169) | 2.75888134 |
| 163 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 2.75888134 |
| 164 | regulation of sarcomere organization (GO:0060297) | 2.74060586 |
| 165 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 2.71430316 |
| 166 | relaxation of cardiac muscle (GO:0055119) | 2.71408222 |
| 167 | response to monoamine (GO:0071867) | 2.69807451 |
| 168 | response to catecholamine (GO:0071869) | 2.69807451 |
| 169 | response to inactivity (GO:0014854) | 2.68310727 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.90970807 |
| 2 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.18764442 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.16006386 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.13979441 |
| 5 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.12427356 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.83459017 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.83459017 |
| 8 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.79043686 |
| 9 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.77532374 |
| 10 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.68808341 |
| 11 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.61072050 |
| 12 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.59290503 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.59006728 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.54666520 |
| 15 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.52011816 |
| 16 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.48245190 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.47981934 |
| 18 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.45088358 |
| 19 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.35357796 |
| 20 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.33534507 |
| 21 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.24878829 |
| 22 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.12336423 |
| 23 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.11085066 |
| 24 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.10545205 |
| 25 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.04493757 |
| 26 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.02252310 |
| 27 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.99005369 |
| 28 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.95876195 |
| 29 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.90557988 |
| 30 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.77211886 |
| 31 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.64118007 |
| 32 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.63975189 |
| 33 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.63262316 |
| 34 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.62532479 |
| 35 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.59927171 |
| 36 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.56265317 |
| 37 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.54160172 |
| 38 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.53040792 |
| 39 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.51067797 |
| 40 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.50642085 |
| 41 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.49933614 |
| 42 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.46248682 |
| 43 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.45639083 |
| 44 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.45415945 |
| 45 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.43079143 |
| 46 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.43079143 |
| 47 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.40267050 |
| 48 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.40125182 |
| 49 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.39397142 |
| 50 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.35582505 |
| 51 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.33546465 |
| 52 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.30534269 |
| 53 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.29243615 |
| 54 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.28195473 |
| 55 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.26627173 |
| 56 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.26196766 |
| 57 | P300_19829295_ChIP-Seq_ESCs_Human | 1.24362066 |
| 58 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.23297103 |
| 59 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.21892685 |
| 60 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.21635009 |
| 61 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.21042305 |
| 62 | AR_25329375_ChIP-Seq_VCAP_Human | 1.19869096 |
| 63 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.19577159 |
| 64 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.18750359 |
| 65 | AR_19668381_ChIP-Seq_PC3_Human | 1.17748674 |
| 66 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.17372889 |
| 67 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.16770232 |
| 68 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.15246244 |
| 69 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.14569094 |
| 70 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.14200344 |
| 71 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.12643213 |
| 72 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.12075032 |
| 73 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.11940176 |
| 74 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.11347396 |
| 75 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.09733281 |
| 76 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.08899043 |
| 77 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.08210698 |
| 78 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.04921488 |
| 79 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.04497347 |
| 80 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.04185488 |
| 81 | STAT3_23295773_ChIP-Seq_U87_Human | 1.03361585 |
| 82 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.02610847 |
| 83 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01821798 |
| 84 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.01414464 |
| 85 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.01057099 |
| 86 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.00470886 |
| 87 | KDM2B_26808549_Chip-Seq_K562_Human | 0.99397158 |
| 88 | * RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.98766004 |
| 89 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.97670739 |
| 90 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.96741949 |
| 91 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.96391919 |
| 92 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.95317085 |
| 93 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.94927583 |
| 94 | TCF4_23295773_ChIP-Seq_U87_Human | 0.94736456 |
| 95 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94724093 |
| 96 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.94299391 |
| 97 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.94255840 |
| 98 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.94186076 |
| 99 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.93650492 |
| 100 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.93468682 |
| 101 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.92613268 |
| 102 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.92059426 |
| 103 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.91508820 |
| 104 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.91356443 |
| 105 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.90709640 |
| 106 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.90088008 |
| 107 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.88591212 |
| 108 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.87809159 |
| 109 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.87794789 |
| 110 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.87794789 |
| 111 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.85498736 |
| 112 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.85473385 |
| 113 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.84902048 |
| 114 | * TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.84513030 |
| 115 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.84357258 |
| 116 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.83985324 |
| 117 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.83655742 |
| 118 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.82470536 |
| 119 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.82204963 |
| 120 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.81034365 |
| 121 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.80796153 |
| 122 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.79633518 |
| 123 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.79209565 |
| 124 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.78548291 |
| 125 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.78065217 |
| 126 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.77706423 |
| 127 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.75094982 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.41000685 |
| 2 | MP0003880_abnormal_central_pattern | 3.92033546 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.77982072 |
| 4 | MP0009046_muscle_twitch | 3.41254917 |
| 5 | MP0005423_abnormal_somatic_nervous | 3.40214047 |
| 6 | MP0004270_analgesia | 3.08233697 |
| 7 | MP0009745_abnormal_behavioral_response | 3.02853285 |
| 8 | MP0002063_abnormal_learning/memory/cond | 2.94852976 |
| 9 | MP0002064_seizures | 2.89487144 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.69538235 |
| 11 | MP0001486_abnormal_startle_reflex | 2.65156922 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.58742958 |
| 13 | MP0002734_abnormal_mechanical_nocicepti | 2.46904810 |
| 14 | MP0002272_abnormal_nervous_system | 2.45326920 |
| 15 | MP0005645_abnormal_hypothalamus_physiol | 2.45192113 |
| 16 | MP0005330_cardiomyopathy | 2.38316464 |
| 17 | MP0002735_abnormal_chemical_nociception | 2.26072847 |
| 18 | MP0000749_muscle_degeneration | 2.23485473 |
| 19 | MP0001440_abnormal_grooming_behavior | 2.22213290 |
| 20 | MP0002736_abnormal_nociception_after | 2.15792034 |
| 21 | MP0008569_lethality_at_weaning | 2.07524367 |
| 22 | MP0000778_abnormal_nervous_system | 2.05138757 |
| 23 | MP0002733_abnormal_thermal_nociception | 2.04252867 |
| 24 | MP0002067_abnormal_sensory_capabilities | 2.01937615 |
| 25 | MP0006138_congestive_heart_failure | 1.99788186 |
| 26 | MP0002184_abnormal_innervation | 1.98248541 |
| 27 | MP0004858_abnormal_nervous_system | 1.94583682 |
| 28 | MP0001970_abnormal_pain_threshold | 1.89742107 |
| 29 | MP0005385_cardiovascular_system_phenoty | 1.88106738 |
| 30 | MP0001544_abnormal_cardiovascular_syste | 1.88106738 |
| 31 | MP0006276_abnormal_autonomic_nervous | 1.86139816 |
| 32 | MP0001501_abnormal_sleep_pattern | 1.84684787 |
| 33 | MP0004087_abnormal_muscle_fiber | 1.83687724 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.82512744 |
| 35 | MP0003329_amyloid_beta_deposits | 1.82331905 |
| 36 | MP0005386_behavior/neurological_phenoty | 1.77571549 |
| 37 | MP0004924_abnormal_behavior | 1.77571549 |
| 38 | MP0001984_abnormal_olfaction | 1.74024785 |
| 39 | MP0000751_myopathy | 1.73117150 |
| 40 | MP0008775_abnormal_heart_ventricle | 1.72999270 |
| 41 | MP0002822_catalepsy | 1.72974121 |
| 42 | MP0009780_abnormal_chondrocyte_physiolo | 1.71648665 |
| 43 | MP0005670_abnormal_white_adipose | 1.71484250 |
| 44 | MP0005646_abnormal_pituitary_gland | 1.68042490 |
| 45 | MP0004885_abnormal_endolymph | 1.62128654 |
| 46 | MP0004811_abnormal_neuron_physiology | 1.61146728 |
| 47 | MP0010630_abnormal_cardiac_muscle | 1.60181307 |
| 48 | MP0000955_abnormal_spinal_cord | 1.55189952 |
| 49 | MP0002127_abnormal_cardiovascular_syste | 1.52982003 |
| 50 | MP0002837_dystrophic_cardiac_calcinosis | 1.51583966 |
| 51 | MP0002882_abnormal_neuron_morphology | 1.48423788 |
| 52 | MP0001502_abnormal_circadian_rhythm | 1.48365588 |
| 53 | MP0002909_abnormal_adrenal_gland | 1.46790489 |
| 54 | MP0002269_muscular_atrophy | 1.45940767 |
| 55 | MP0003879_abnormal_hair_cell | 1.44256444 |
| 56 | MP0004215_abnormal_myocardial_fiber | 1.43875293 |
| 57 | MP0004130_abnormal_muscle_cell | 1.43758371 |
| 58 | MP0004142_abnormal_muscle_tone | 1.42415242 |
| 59 | MP0000569_abnormal_digit_pigmentation | 1.40677110 |
| 60 | MP0002066_abnormal_motor_capabilities/c | 1.40249173 |
| 61 | MP0002106_abnormal_muscle_physiology | 1.38087556 |
| 62 | MP0001529_abnormal_vocalization | 1.37993692 |
| 63 | MP0003646_muscle_fatigue | 1.34939197 |
| 64 | MP0010368_abnormal_lymphatic_system | 1.32506924 |
| 65 | MP0003279_aneurysm | 1.29422671 |
| 66 | MP0003137_abnormal_impulse_conducting | 1.26910587 |
| 67 | MP0000750_abnormal_muscle_regeneration | 1.26298464 |
| 68 | MP0005551_abnormal_eye_electrophysiolog | 1.25646152 |
| 69 | MP0003787_abnormal_imprinting | 1.23349258 |
| 70 | MP0001188_hyperpigmentation | 1.21766726 |
| 71 | MP0002638_abnormal_pupillary_reflex | 1.19744376 |
| 72 | MP0002152_abnormal_brain_morphology | 1.18690821 |
| 73 | MP0003633_abnormal_nervous_system | 1.18528392 |
| 74 | MP0002332_abnormal_exercise_endurance | 1.18428911 |
| 75 | MP0005369_muscle_phenotype | 1.15086971 |
| 76 | MP0001905_abnormal_dopamine_level | 1.14360289 |
| 77 | MP0004145_abnormal_muscle_electrophysio | 1.11808348 |
| 78 | MP0000759_abnormal_skeletal_muscle | 1.11417176 |
| 79 | MP0003634_abnormal_glial_cell | 1.11067889 |
| 80 | MP0009384_cardiac_valve_regurgitation | 1.08619735 |
| 81 | MP0003828_pulmonary_edema | 1.08568843 |
| 82 | MP0003690_abnormal_glial_cell | 1.07721415 |
| 83 | MP0003631_nervous_system_phenotype | 1.07252317 |
| 84 | MP0000747_muscle_weakness | 1.06680762 |
| 85 | MP0005165_increased_susceptibility_to | 1.06290976 |
| 86 | MP0004085_abnormal_heartbeat | 1.05243017 |
| 87 | MP0002295_abnormal_pulmonary_circulatio | 1.04888003 |
| 88 | MP0004742_abnormal_vestibular_system | 1.03668975 |
| 89 | MP0005503_abnormal_tendon_morphology | 1.03234729 |
| 90 | MP0008004_abnormal_stomach_pH | 1.03055835 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 1.01134612 |
| 92 | MP0003122_maternal_imprinting | 0.98291437 |
| 93 | MP0002229_neurodegeneration | 0.96747310 |
| 94 | MP0002752_abnormal_somatic_nervous | 0.94354363 |
| 95 | MP0008995_early_reproductive_senescence | 0.94052425 |
| 96 | MP0002090_abnormal_vision | 0.93439285 |
| 97 | MP0001958_emphysema | 0.91426257 |
| 98 | MP0003632_abnormal_nervous_system | 0.90924438 |
| 99 | MP0004233_abnormal_muscle_weight | 0.89441673 |
| 100 | MP0001963_abnormal_hearing_physiology | 0.86752839 |
| 101 | MP0000920_abnormal_myelination | 0.82928745 |
| 102 | MP0002069_abnormal_eating/drinking_beha | 0.82593020 |
| 103 | MP0004484_altered_response_of | 0.82045390 |
| 104 | MP0005394_taste/olfaction_phenotype | 0.81444706 |
| 105 | MP0005499_abnormal_olfactory_system | 0.81444706 |
| 106 | MP0000639_abnormal_adrenal_gland | 0.80630958 |
| 107 | MP0002234_abnormal_pharynx_morphology | 0.78495347 |
| 108 | MP0008438_abnormal_cutaneous_collagen | 0.78160753 |
| 109 | MP0006072_abnormal_retinal_apoptosis | 0.76532428 |
| 110 | MP0000026_abnormal_inner_ear | 0.76062027 |
| 111 | MP0008872_abnormal_physiological_respon | 0.74894430 |
| 112 | MP0003283_abnormal_digestive_organ | 0.73824449 |
| 113 | MP0003221_abnormal_cardiomyocyte_apopto | 0.72580791 |
| 114 | MP0001299_abnormal_eye_distance/ | 0.71557492 |
| 115 | MP0001485_abnormal_pinna_reflex | 0.71072568 |
| 116 | MP0001177_atelectasis | 0.71044704 |
| 117 | MP0000013_abnormal_adipose_tissue | 0.70035516 |
| 118 | MP0005623_abnormal_meninges_morphology | 0.69160964 |
| 119 | MP0000230_abnormal_systemic_arterial | 0.67870962 |
| 120 | MP0000604_amyloidosis | 0.67782542 |
| 121 | MP0005595_abnormal_vascular_smooth | 0.67277483 |
| 122 | MP0005409_darkened_coat_color | 0.66325598 |
| 123 | MP0005253_abnormal_eye_physiology | 0.65462833 |
| 124 | MP0010386_abnormal_urinary_bladder | 0.64886478 |
| 125 | MP0002972_abnormal_cardiac_muscle | 0.64146891 |
| 126 | MP0005620_abnormal_muscle_contractility | 0.63956098 |
| 127 | MP0003861_abnormal_nervous_system | 0.63834077 |
| 128 | MP0003075_altered_response_to | 0.63607326 |
| 129 | MP0005187_abnormal_penis_morphology | 0.61903129 |
| 130 | MP0006292_abnormal_olfactory_placode | 0.60037594 |
| 131 | MP0000767_abnormal_smooth_muscle | 0.60026631 |
| 132 | MP0004036_abnormal_muscle_relaxation | 0.59820660 |
| 133 | MP0005535_abnormal_body_temperature | 0.58657727 |
| 134 | MP0008874_decreased_physiological_sensi | 0.57872097 |
| 135 | MP0004084_abnormal_cardiac_muscle | 0.56612423 |
| 136 | MP0004510_myositis | 0.55872731 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.20353463 |
| 2 | Myokymia (HP:0002411) | 5.89935148 |
| 3 | Progressive cerebellar ataxia (HP:0002073) | 4.91991428 |
| 4 | Epileptic encephalopathy (HP:0200134) | 4.84630364 |
| 5 | Focal seizures (HP:0007359) | 4.73903561 |
| 6 | Visual hallucinations (HP:0002367) | 4.71197490 |
| 7 | Hyporeflexia of lower limbs (HP:0002600) | 4.52134743 |
| 8 | Heart block (HP:0012722) | 4.43267897 |
| 9 | Action tremor (HP:0002345) | 4.28231725 |
| 10 | Febrile seizures (HP:0002373) | 4.23149710 |
| 11 | Abnormal atrioventricular conduction (HP:0005150) | 4.20022825 |
| 12 | Lipoatrophy (HP:0100578) | 4.10546088 |
| 13 | Atrioventricular block (HP:0001678) | 4.10215530 |
| 14 | Ventricular tachycardia (HP:0004756) | 4.04682363 |
| 15 | Abnormality of the calf musculature (HP:0001430) | 4.00396452 |
| 16 | Muscle fiber splitting (HP:0003555) | 3.93037219 |
| 17 | Ventricular arrhythmia (HP:0004308) | 3.74153391 |
| 18 | Asymmetric septal hypertrophy (HP:0001670) | 3.71361491 |
| 19 | Atonic seizures (HP:0010819) | 3.62152781 |
| 20 | Hypoplastic left heart (HP:0004383) | 3.57829932 |
| 21 | Anomalous pulmonary venous return (HP:0010772) | 3.55041508 |
| 22 | Supranuclear gaze palsy (HP:0000605) | 3.49087437 |
| 23 | Broad-based gait (HP:0002136) | 3.44445086 |
| 24 | Right ventricular cardiomyopathy (HP:0011663) | 3.42557232 |
| 25 | Dilated cardiomyopathy (HP:0001644) | 3.40547972 |
| 26 | Absence seizures (HP:0002121) | 3.35629205 |
| 27 | Dysdiadochokinesis (HP:0002075) | 3.35227465 |
| 28 | Generalized tonic-clonic seizures (HP:0002069) | 3.33868327 |
| 29 | Ankle clonus (HP:0011448) | 3.28674374 |
| 30 | Abnormality of the pulmonary veins (HP:0011718) | 3.26669924 |
| 31 | Megalencephaly (HP:0001355) | 3.21302338 |
| 32 | Mutism (HP:0002300) | 3.19134103 |
| 33 | EMG: neuropathic changes (HP:0003445) | 3.17327282 |
| 34 | EMG: myopathic abnormalities (HP:0003458) | 3.11382604 |
| 35 | Hemiparesis (HP:0001269) | 3.09716429 |
| 36 | Distal lower limb muscle weakness (HP:0009053) | 3.08360013 |
| 37 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.04342765 |
| 38 | Subaortic stenosis (HP:0001682) | 3.04342765 |
| 39 | Dialeptic seizures (HP:0011146) | 3.03354155 |
| 40 | Hypoplastic heart (HP:0001961) | 3.02008107 |
| 41 | Calf muscle hypertrophy (HP:0008981) | 3.01466739 |
| 42 | Abnormal eating behavior (HP:0100738) | 3.00508823 |
| 43 | Depression (HP:0000716) | 2.99631801 |
| 44 | Left ventricular hypertrophy (HP:0001712) | 2.99179919 |
| 45 | Gaze-evoked nystagmus (HP:0000640) | 2.94254020 |
| 46 | Anxiety (HP:0000739) | 2.89986279 |
| 47 | Poor eye contact (HP:0000817) | 2.89301767 |
| 48 | Neurofibrillary tangles (HP:0002185) | 2.82865794 |
| 49 | Abnormality of binocular vision (HP:0011514) | 2.81895978 |
| 50 | Diplopia (HP:0000651) | 2.81895978 |
| 51 | Limb dystonia (HP:0002451) | 2.81101012 |
| 52 | Hemiplegia (HP:0002301) | 2.80327115 |
| 53 | Dysmetria (HP:0001310) | 2.79745605 |
| 54 | Truncal ataxia (HP:0002078) | 2.78388152 |
| 55 | Genetic anticipation (HP:0003743) | 2.75795449 |
| 56 | Abnormality of the foot musculature (HP:0001436) | 2.74782475 |
| 57 | Palpitations (HP:0001962) | 2.71337421 |
| 58 | Ventricular fibrillation (HP:0001663) | 2.70560167 |
| 59 | Pheochromocytoma (HP:0002666) | 2.68157555 |
| 60 | Hyperventilation (HP:0002883) | 2.66119169 |
| 61 | Polyphagia (HP:0002591) | 2.65825344 |
| 62 | Postural instability (HP:0002172) | 2.64378891 |
| 63 | Type 1 muscle fiber predominance (HP:0003803) | 2.61535790 |
| 64 | Abnormal social behavior (HP:0012433) | 2.59895955 |
| 65 | Impaired social interactions (HP:0000735) | 2.59895955 |
| 66 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.58181864 |
| 67 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.56749617 |
| 68 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.52969140 |
| 69 | Aplasia of the phalanges of the hand (HP:0009802) | 2.52969140 |
| 70 | Aplasia involving bones of the extremities (HP:0009825) | 2.52969140 |
| 71 | Excessive salivation (HP:0003781) | 2.46195841 |
| 72 | Drooling (HP:0002307) | 2.46195841 |
| 73 | Intention tremor (HP:0002080) | 2.43158349 |
| 74 | Neck muscle weakness (HP:0000467) | 2.40114285 |
| 75 | Foot dorsiflexor weakness (HP:0009027) | 2.40071222 |
| 76 | Neuroendocrine neoplasm (HP:0100634) | 2.37524777 |
| 77 | Cerebral inclusion bodies (HP:0100314) | 2.37016336 |
| 78 | Increased variability in muscle fiber diameter (HP:0003557) | 2.36528099 |
| 79 | Urinary urgency (HP:0000012) | 2.35021981 |
| 80 | Prolonged QT interval (HP:0001657) | 2.33785821 |
| 81 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.33379737 |
| 82 | Scanning speech (HP:0002168) | 2.29838183 |
| 83 | Torticollis (HP:0000473) | 2.29084193 |
| 84 | Difficulty climbing stairs (HP:0003551) | 2.26795324 |
| 85 | Fetal akinesia sequence (HP:0001989) | 2.26775351 |
| 86 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.26133147 |
| 87 | Rimmed vacuoles (HP:0003805) | 2.23653199 |
| 88 | Abnormal ventriculo-arterial connection (HP:0011563) | 2.22195515 |
| 89 | Transposition of the great arteries (HP:0001669) | 2.22195515 |
| 90 | Abnormal connection of the cardiac segments (HP:0011545) | 2.22195515 |
| 91 | Congenital malformation of the right heart (HP:0011723) | 2.21961025 |
| 92 | Double outlet right ventricle (HP:0001719) | 2.21961025 |
| 93 | Abnormal EKG (HP:0003115) | 2.21599666 |
| 94 | Epileptiform EEG discharges (HP:0011182) | 2.21475586 |
| 95 | Spastic gait (HP:0002064) | 2.19224477 |
| 96 | Agitation (HP:0000713) | 2.17425742 |
| 97 | EEG with generalized epileptiform discharges (HP:0011198) | 2.16646992 |
| 98 | Status epilepticus (HP:0002133) | 2.14164449 |
| 99 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.13707684 |
| 100 | Impaired smooth pursuit (HP:0007772) | 2.11873132 |
| 101 | Amblyopia (HP:0000646) | 2.11513809 |
| 102 | Ragged-red muscle fibers (HP:0003200) | 2.11460958 |
| 103 | Bradykinesia (HP:0002067) | 2.11319986 |
| 104 | Bradycardia (HP:0001662) | 2.11252572 |
| 105 | Hypsarrhythmia (HP:0002521) | 2.09913983 |
| 106 | Abnormality of the corticospinal tract (HP:0002492) | 2.09506797 |
| 107 | Exercise-induced myalgia (HP:0003738) | 2.08469220 |
| 108 | Gonadal dysgenesis (HP:0000133) | 2.07238897 |
| 109 | Lower limb muscle weakness (HP:0007340) | 2.05332138 |
| 110 | Progressive inability to walk (HP:0002505) | 2.04335123 |
| 111 | Obstructive sleep apnea (HP:0002870) | 2.04334814 |
| 112 | Bundle branch block (HP:0011710) | 2.04191349 |
| 113 | Narrow nasal bridge (HP:0000446) | 2.01343477 |
| 114 | Lower limb amyotrophy (HP:0007210) | 2.00618253 |
| 115 | Postural tremor (HP:0002174) | 2.00294984 |
| 116 | Testicular neoplasm (HP:0010788) | 2.00127800 |
| 117 | Stereotypic behavior (HP:0000733) | 1.99974576 |
| 118 | Primary atrial arrhythmia (HP:0001692) | 1.99895143 |
| 119 | Focal dystonia (HP:0004373) | 1.99823805 |
| 120 | Syncope (HP:0001279) | 1.99567338 |
| 121 | Atrial fibrillation (HP:0005110) | 1.99563893 |
| 122 | Protrusio acetabuli (HP:0003179) | 1.99024878 |
| 123 | Dysmetric saccades (HP:0000641) | 1.98361236 |
| 124 | Sudden death (HP:0001699) | 1.98106326 |
| 125 | Gait imbalance (HP:0002141) | 1.97882634 |
| 126 | Distal upper limb amyotrophy (HP:0007149) | 1.97488965 |
| 127 | Upper limb amyotrophy (HP:0009129) | 1.97488965 |
| 128 | Hand muscle atrophy (HP:0009130) | 1.96632507 |
| 129 | Myotonia (HP:0002486) | 1.96531128 |
| 130 | Hypoplasia of the brainstem (HP:0002365) | 1.94705021 |
| 131 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.94705021 |
| 132 | Increased connective tissue (HP:0009025) | 1.92544350 |
| 133 | Scapular winging (HP:0003691) | 1.90593010 |
| 134 | Steppage gait (HP:0003376) | 1.90180238 |
| 135 | Incomplete penetrance (HP:0003829) | 1.89019181 |
| 136 | Mesangial abnormality (HP:0001966) | 1.88954855 |
| 137 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.88258039 |
| 138 | Retinal dysplasia (HP:0007973) | 1.87565698 |
| 139 | Sleep apnea (HP:0010535) | 1.86172170 |
| 140 | Distal lower limb amyotrophy (HP:0008944) | 1.85387481 |
| 141 | Central scotoma (HP:0000603) | 1.84690862 |
| 142 | Termporal pattern (HP:0011008) | 1.84549977 |
| 143 | Insidious onset (HP:0003587) | 1.84549977 |
| 144 | Supraventricular tachycardia (HP:0004755) | 1.84013095 |
| 145 | Abnormality of the lower motor neuron (HP:0002366) | 1.83877662 |
| 146 | Limb-girdle muscle atrophy (HP:0003797) | 1.83769287 |
| 147 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.83711482 |
| 148 | Specific learning disability (HP:0001328) | 1.83429258 |
| 149 | Amyotrophic lateral sclerosis (HP:0007354) | 1.82762754 |
| 150 | Papilledema (HP:0001085) | 1.79710357 |
| 151 | Sudden cardiac death (HP:0001645) | 1.79446319 |
| 152 | Insomnia (HP:0100785) | 1.79368396 |
| 153 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.78889912 |
| 154 | Limb-girdle muscle weakness (HP:0003325) | 1.78312910 |
| 155 | Diaphragmatic weakness (HP:0009113) | 1.78113872 |
| 156 | Hypoventilation (HP:0002791) | 1.76902646 |
| 157 | Craniofacial dystonia (HP:0012179) | 1.76837455 |
| 158 | Supraventricular arrhythmia (HP:0005115) | 1.76569111 |
| 159 | Complete atrioventricular canal defect (HP:0001674) | 1.76152448 |
| 160 | Abnormality of the vocal cords (HP:0008777) | 1.75328676 |
| 161 | Bulbar palsy (HP:0001283) | 1.74998399 |
| 162 | Horizontal nystagmus (HP:0000666) | 1.74780398 |
| 163 | Abnormality of the tricuspid valve (HP:0001702) | 1.72502566 |
| 164 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.69078429 |
| 165 | Preauricular pit (HP:0004467) | 1.69016001 |
| 166 | Periauricular skin pits (HP:0100277) | 1.69016001 |
| 167 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.64745953 |
| 168 | Atrioventricular canal defect (HP:0006695) | 1.64261247 |
| 169 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.63030788 |
| 170 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.63030788 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYLK | 5.27758317 |
| 2 | MARK1 | 4.40467311 |
| 3 | TTN | 4.00344006 |
| 4 | NTRK3 | 3.51217900 |
| 5 | EPHA4 | 3.35332149 |
| 6 | MAP3K4 | 3.14072407 |
| 7 | NTRK2 | 2.84626693 |
| 8 | MAP3K9 | 2.69614855 |
| 9 | MINK1 | 2.69236409 |
| 10 | PHKG1 | 2.66058555 |
| 11 | PHKG2 | 2.66058555 |
| 12 | MAP2K7 | 2.65764430 |
| 13 | PAK6 | 2.21594755 |
| 14 | LMTK2 | 2.17250596 |
| 15 | CASK | 2.10399485 |
| 16 | DAPK2 | 2.09756860 |
| 17 | MAPK13 | 1.84127397 |
| 18 | TNIK | 1.82166828 |
| 19 | MAP2K4 | 1.66691420 |
| 20 | MAP3K12 | 1.64882831 |
| 21 | MAP3K6 | 1.60090313 |
| 22 | PRPF4B | 1.48118846 |
| 23 | CAMKK1 | 1.45526438 |
| 24 | PLK2 | 1.42922962 |
| 25 | OBSCN | 1.42816372 |
| 26 | MUSK | 1.42704274 |
| 27 | CDK5 | 1.42262500 |
| 28 | NTRK1 | 1.38298709 |
| 29 | GRK5 | 1.34586568 |
| 30 | EPHA3 | 1.34513872 |
| 31 | PRKD3 | 1.31698262 |
| 32 | SGK494 | 1.29520349 |
| 33 | SGK223 | 1.29520349 |
| 34 | PDK4 | 1.27914926 |
| 35 | PDK3 | 1.27914926 |
| 36 | PINK1 | 1.24512491 |
| 37 | STK38 | 1.22586294 |
| 38 | UHMK1 | 1.22158829 |
| 39 | PRKD1 | 1.18261762 |
| 40 | PRKCG | 1.17939439 |
| 41 | KSR1 | 1.17230773 |
| 42 | SIK2 | 1.15403966 |
| 43 | SGK2 | 1.13451694 |
| 44 | CDK19 | 1.05313975 |
| 45 | DYRK1A | 0.98039553 |
| 46 | CAMK2A | 0.97090756 |
| 47 | TESK1 | 0.96228715 |
| 48 | CAMKK2 | 0.95938879 |
| 49 | LATS2 | 0.95603248 |
| 50 | DAPK1 | 0.93015887 |
| 51 | GRK7 | 0.92328649 |
| 52 | EPHB2 | 0.90415458 |
| 53 | KSR2 | 0.89599873 |
| 54 | PNCK | 0.88889827 |
| 55 | CDK18 | 0.88784207 |
| 56 | SGK3 | 0.88113886 |
| 57 | MAP3K7 | 0.87333292 |
| 58 | PAK3 | 0.87193694 |
| 59 | CDK15 | 0.86396414 |
| 60 | CAMK1 | 0.85148774 |
| 61 | TYRO3 | 0.83629788 |
| 62 | PRKAA1 | 0.83194667 |
| 63 | TAOK1 | 0.80602423 |
| 64 | CDK14 | 0.79941503 |
| 65 | PRKCE | 0.79614848 |
| 66 | PKN1 | 0.79135705 |
| 67 | STK11 | 0.78990397 |
| 68 | DDR2 | 0.77764953 |
| 69 | AKT3 | 0.77437054 |
| 70 | PRKCH | 0.77350430 |
| 71 | EPHB1 | 0.76658855 |
| 72 | ERBB3 | 0.75819432 |
| 73 | MAP3K5 | 0.75478237 |
| 74 | CDK11A | 0.74439617 |
| 75 | WNK1 | 0.73574273 |
| 76 | SIK3 | 0.73253166 |
| 77 | PDGFRA | 0.73091151 |
| 78 | RPS6KL1 | 0.72763736 |
| 79 | RPS6KC1 | 0.72763736 |
| 80 | DYRK2 | 0.72338663 |
| 81 | FES | 0.71283742 |
| 82 | DAPK3 | 0.70418409 |
| 83 | CSNK1G2 | 0.70171121 |
| 84 | MARK2 | 0.70093337 |
| 85 | SGK1 | 0.69130557 |
| 86 | STK38L | 0.68548767 |
| 87 | PIK3CA | 0.67117060 |
| 88 | CDC42BPA | 0.66723552 |
| 89 | CAMK2B | 0.66087932 |
| 90 | CAMK1G | 0.62685599 |
| 91 | RPS6KA6 | 0.62619591 |
| 92 | PDK2 | 0.61634565 |
| 93 | DMPK | 0.60642868 |
| 94 | MAPK12 | 0.60590180 |
| 95 | MAPK4 | 0.59260598 |
| 96 | RIPK1 | 0.57247387 |
| 97 | RIPK4 | 0.56869785 |
| 98 | CAMK2D | 0.56610810 |
| 99 | RET | 0.55961038 |
| 100 | ROCK2 | 0.54422939 |
| 101 | STK4 | 0.54111145 |
| 102 | DYRK1B | 0.53065294 |
| 103 | CAMK2G | 0.52257177 |
| 104 | WNK3 | 0.51768265 |
| 105 | ROCK1 | 0.51376762 |
| 106 | NEK6 | 0.50534000 |
| 107 | PRKCZ | 0.50406502 |
| 108 | OXSR1 | 0.49217896 |
| 109 | MAP3K2 | 0.48896577 |
| 110 | RPS6KA3 | 0.48511385 |
| 111 | ALK | 0.48275680 |
| 112 | AKT2 | 0.47905147 |
| 113 | CAMK4 | 0.47444514 |
| 114 | NEK9 | 0.47071191 |
| 115 | MAP4K2 | 0.45240277 |
| 116 | BCKDK | 0.44987280 |
| 117 | LIMK1 | 0.43747275 |
| 118 | RPS6KA2 | 0.43286545 |
| 119 | MAPK7 | 0.42022295 |
| 120 | PRKACA | 0.42007515 |
| 121 | FYN | 0.41768646 |
| 122 | TIE1 | 0.41759671 |
| 123 | BCR | 0.40597047 |
| 124 | ICK | 0.40411528 |
| 125 | PDK1 | 0.39919069 |
| 126 | PRKG1 | 0.39269525 |
| 127 | ADRBK1 | 0.37881843 |
| 128 | BMPR1B | 0.35205255 |
| 129 | PDPK1 | 0.34872584 |
| 130 | ARAF | 0.33836715 |
| 131 | PRKACG | 0.33782460 |
| 132 | MAPK10 | 0.33719254 |
| 133 | IRAK2 | 0.33408952 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.07974924 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.25690142 |
| 3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.00990134 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.88732532 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.70102738 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.63362838 |
| 7 | Circadian entrainment_Homo sapiens_hsa04713 | 2.60368449 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.47182451 |
| 9 | Olfactory transduction_Homo sapiens_hsa04740 | 2.32887678 |
| 10 | Long-term potentiation_Homo sapiens_hsa04720 | 2.15069665 |
| 11 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.12919606 |
| 12 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.06771496 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 2.01958865 |
| 14 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.99411897 |
| 15 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.98697764 |
| 16 | Taste transduction_Homo sapiens_hsa04742 | 1.90336725 |
| 17 | Insulin secretion_Homo sapiens_hsa04911 | 1.86716665 |
| 18 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.80609121 |
| 19 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.76374303 |
| 20 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.73338229 |
| 21 | Long-term depression_Homo sapiens_hsa04730 | 1.67136698 |
| 22 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.63083042 |
| 23 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.58517158 |
| 24 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.55788169 |
| 25 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.54075484 |
| 26 | Cocaine addiction_Homo sapiens_hsa05030 | 1.52741390 |
| 27 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.47381833 |
| 28 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.45751867 |
| 29 | Renin secretion_Homo sapiens_hsa04924 | 1.44956638 |
| 30 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.44532485 |
| 31 | Axon guidance_Homo sapiens_hsa04360 | 1.35068860 |
| 32 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.29062670 |
| 33 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.26619266 |
| 34 | Gap junction_Homo sapiens_hsa04540 | 1.25718126 |
| 35 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.25514096 |
| 36 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.25279151 |
| 37 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.22393133 |
| 38 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.18943106 |
| 39 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.16944791 |
| 40 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.13004812 |
| 41 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.05775840 |
| 42 | Prion diseases_Homo sapiens_hsa05020 | 1.02345928 |
| 43 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.02234561 |
| 44 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.98776568 |
| 45 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.98197412 |
| 46 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.96672936 |
| 47 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.95437480 |
| 48 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.92865238 |
| 49 | Melanogenesis_Homo sapiens_hsa04916 | 0.91842158 |
| 50 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.90761173 |
| 51 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.90624803 |
| 52 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.86832992 |
| 53 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.86739706 |
| 54 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.86514880 |
| 55 | Phototransduction_Homo sapiens_hsa04744 | 0.86490326 |
| 56 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.85905374 |
| 57 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.80823872 |
| 58 | Glioma_Homo sapiens_hsa05214 | 0.80161486 |
| 59 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.78216702 |
| 60 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.78127400 |
| 61 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.76201506 |
| 62 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.75752522 |
| 63 | Carbon metabolism_Homo sapiens_hsa01200 | 0.75016238 |
| 64 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.74685999 |
| 65 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.74579823 |
| 66 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.73829192 |
| 67 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.73174142 |
| 68 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.72769076 |
| 69 | Alzheimers disease_Homo sapiens_hsa05010 | 0.72519839 |
| 70 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.72337039 |
| 71 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.71749395 |
| 72 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.69002668 |
| 73 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.68732137 |
| 74 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.67407433 |
| 75 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.66989607 |
| 76 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.65280159 |
| 77 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.64170760 |
| 78 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.62642681 |
| 79 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.62587172 |
| 80 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.62471252 |
| 81 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.61815888 |
| 82 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.61730771 |
| 83 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.61473824 |
| 84 | Focal adhesion_Homo sapiens_hsa04510 | 0.61091669 |
| 85 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.58955427 |
| 86 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.58791856 |
| 87 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.56695263 |
| 88 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.56534081 |
| 89 | Parkinsons disease_Homo sapiens_hsa05012 | 0.56493906 |
| 90 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.56301929 |
| 91 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.55976996 |
| 92 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.55441552 |
| 93 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.55393692 |
| 94 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.53994393 |
| 95 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.53273177 |
| 96 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.52578661 |
| 97 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.51972516 |
| 98 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.50544364 |
| 99 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.50164869 |
| 100 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49256213 |
| 101 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.47424643 |
| 102 | Tight junction_Homo sapiens_hsa04530 | 0.47146277 |
| 103 | Circadian rhythm_Homo sapiens_hsa04710 | 0.47093411 |
| 104 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.45753274 |
| 105 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.45040832 |
| 106 | Alcoholism_Homo sapiens_hsa05034 | 0.44373822 |
| 107 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.43679917 |
| 108 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.42912632 |
| 109 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.42442965 |
| 110 | Endometrial cancer_Homo sapiens_hsa05213 | 0.41856639 |
| 111 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.40636195 |
| 112 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.39971157 |
| 113 | Endocytosis_Homo sapiens_hsa04144 | 0.39739476 |
| 114 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.36374436 |
| 115 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.36042698 |
| 116 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.34834316 |
| 117 | Huntingtons disease_Homo sapiens_hsa05016 | 0.34106012 |
| 118 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.33317769 |
| 119 | Bile secretion_Homo sapiens_hsa04976 | 0.32355109 |
| 120 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.32238199 |
| 121 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.32206854 |
| 122 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.29625792 |
| 123 | Colorectal cancer_Homo sapiens_hsa05210 | 0.28963387 |
| 124 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.28835357 |
| 125 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.27887894 |

