CSDE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of centriole replication (GO:0046599)4.70461642
2COPI coating of Golgi vesicle (GO:0048205)4.46975156
3Golgi transport vesicle coating (GO:0048200)4.46975156
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.37198138
5DNA unwinding involved in DNA replication (GO:0006268)4.23268140
6regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.97280320
7kinetochore organization (GO:0051383)3.87712370
8cullin deneddylation (GO:0010388)3.87295215
9regulation of RNA export from nucleus (GO:0046831)3.74332506
10positive regulation of keratinocyte differentiation (GO:0045618)3.69226624
11embryonic camera-type eye morphogenesis (GO:0048596)3.68816773
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.68322750
13regulation of mitotic spindle checkpoint (GO:1903504)3.68322750
14meiotic chromosome segregation (GO:0045132)3.65177646
15nuclear pore complex assembly (GO:0051292)3.56202872
16negative regulation of phagocytosis (GO:0050765)3.54308631
17protein deneddylation (GO:0000338)3.52368760
18purine nucleobase biosynthetic process (GO:0009113)3.48057775
19DNA ligation (GO:0006266)3.47177495
20peptidyl-lysine dimethylation (GO:0018027)3.46873190
21CENP-A containing nucleosome assembly (GO:0034080)3.46386473
22peptidyl-arginine omega-N-methylation (GO:0035247)3.45849185
23nuclear pore organization (GO:0006999)3.45618923
24establishment of chromosome localization (GO:0051303)3.41850653
25poly(A)+ mRNA export from nucleus (GO:0016973)3.40246685
26viral mRNA export from host cell nucleus (GO:0046784)3.37886407
27attachment of spindle microtubules to kinetochore (GO:0008608)3.37050445
28kinetochore assembly (GO:0051382)3.35316571
29DNA double-strand break processing (GO:0000729)3.32527723
30embryonic eye morphogenesis (GO:0048048)3.31253081
31regulation of nucleobase-containing compound transport (GO:0032239)3.29874608
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.29808428
33mitotic metaphase plate congression (GO:0007080)3.29445795
34heart process (GO:0003015)3.27895632
35heart contraction (GO:0060047)3.27895632
36nucleobase biosynthetic process (GO:0046112)3.27769701
37skeletal muscle adaptation (GO:0043501)3.27590801
38metaphase plate congression (GO:0051310)3.27356212
39RNA stabilization (GO:0043489)3.25888646
40mRNA stabilization (GO:0048255)3.25888646
41chromatin remodeling at centromere (GO:0031055)3.25634410
42paraxial mesoderm development (GO:0048339)3.24799777
43response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.23928607
44striated muscle atrophy (GO:0014891)3.22747809
45histone H2A acetylation (GO:0043968)3.22426209
46DNA duplex unwinding (GO:0032508)3.20849459
47pre-miRNA processing (GO:0031054)3.20651607
48peptidyl-arginine N-methylation (GO:0035246)3.20052005
49peptidyl-arginine methylation (GO:0018216)3.20052005
50regulation of translational fidelity (GO:0006450)3.18866902
51DNA topological change (GO:0006265)3.18801789
52RNA-dependent DNA replication (GO:0006278)3.15833190
53spliceosomal tri-snRNP complex assembly (GO:0000244)3.15152963
54protein K11-linked deubiquitination (GO:0035871)3.15109300
55protein complex localization (GO:0031503)3.13876203
56monoubiquitinated protein deubiquitination (GO:0035520)3.13679094
57IMP biosynthetic process (GO:0006188)3.12255702
58negative regulation of DNA repair (GO:0045738)3.09517791
59protein localization to microtubule (GO:0035372)3.09019346
60negative regulation of mast cell activation (GO:0033004)3.08234785
61formation of translation preinitiation complex (GO:0001731)3.08170679
62pore complex assembly (GO:0046931)3.07301907
63regulation of histone H3-K27 methylation (GO:0061085)3.06806460
64DNA geometric change (GO:0032392)3.04441827
65regulation of DNA-templated transcription, initiation (GO:2000142)3.03856379
66muscle atrophy (GO:0014889)2.99558459
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98818509
68microtubule depolymerization (GO:0007019)2.98059420
69replication fork processing (GO:0031297)2.97551884
70regulation of DNA endoreduplication (GO:0032875)2.97405707
71metanephric mesenchyme development (GO:0072075)2.96084844
72maternal placenta development (GO:0001893)2.96016944
73positive regulation of mitotic sister chromatid separation (GO:1901970)2.95123713
74positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95123713
75positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95123713
76protein K6-linked ubiquitination (GO:0085020)2.94004045
77interkinetic nuclear migration (GO:0022027)2.93612891
78cellular protein complex localization (GO:0034629)2.93366767
79histone H2B ubiquitination (GO:0033523)2.93344283
80mitotic sister chromatid cohesion (GO:0007064)2.92856707
81neural tube formation (GO:0001841)2.91434661
82regulation of centrosome duplication (GO:0010824)2.91093000
83DNA replication-independent nucleosome assembly (GO:0006336)2.89596038
84DNA replication-independent nucleosome organization (GO:0034724)2.89596038
85definitive hemopoiesis (GO:0060216)2.87735509
86protein-DNA complex disassembly (GO:0032986)2.87728668
87nucleosome disassembly (GO:0006337)2.87728668
88regulation of nuclear cell cycle DNA replication (GO:0033262)2.87123310
89COPII vesicle coating (GO:0048208)2.84718488
90negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.84426846
91ear development (GO:0043583)2.83971108
92focal adhesion assembly (GO:0048041)2.82513747
93cell-substrate adherens junction assembly (GO:0007045)2.82513747
94histone exchange (GO:0043486)2.81999305
95protein export from nucleus (GO:0006611)2.80682769
96spindle checkpoint (GO:0031577)2.79939369
97mitotic chromosome condensation (GO:0007076)2.77789733
98adherens junction assembly (GO:0034333)2.76916317
99kidney mesenchyme development (GO:0072074)2.76435613
100regulation of mitotic spindle organization (GO:0060236)2.76368557
101protein localization to chromosome, centromeric region (GO:0071459)2.76101353
102histone arginine methylation (GO:0034969)2.75862482
103protein localization to kinetochore (GO:0034501)2.75515215
104establishment of integrated proviral latency (GO:0075713)2.75054395
105vesicle coating (GO:0006901)2.74456186
106DNA catabolic process, exonucleolytic (GO:0000738)2.74418777
107regulation of spindle organization (GO:0090224)2.73919447
108regulation of centrosome cycle (GO:0046605)2.73180274
109regulation of glucose import in response to insulin stimulus (GO:2001273)2.72646990
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.72545615
111nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.72178120
112regulation of transcription from RNA polymerase I promoter (GO:0006356)2.71207773
113negative regulation of DNA-dependent DNA replication (GO:2000104)2.70742216
114negative regulation of keratinocyte proliferation (GO:0010839)2.70376713
115intestinal epithelial cell development (GO:0060576)2.70192940
116mesenchymal cell differentiation involved in kidney development (GO:0072161)2.68672262
117mesenchymal cell differentiation involved in renal system development (GO:2001012)2.68672262
118positive regulation of cell cycle checkpoint (GO:1901978)2.68202641
119sister chromatid cohesion (GO:0007062)2.66632297
120ribosome assembly (GO:0042255)2.66001560
121mitotic recombination (GO:0006312)2.65953696
122intraciliary transport (GO:0042073)2.65946835
123regulation of NFAT protein import into nucleus (GO:0051532)2.65374018
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63168878
1257-methylguanosine mRNA capping (GO:0006370)2.62463176
126RNA capping (GO:0036260)2.61254452
1277-methylguanosine RNA capping (GO:0009452)2.61254452
128regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60902541
129transcription initiation from RNA polymerase I promoter (GO:0006361)2.60695662
130vagina development (GO:0060068)2.59336848
131embryonic retina morphogenesis in camera-type eye (GO:0060059)2.59278282
132histamine secretion (GO:0001821)2.59248350
133regulation of sister chromatid cohesion (GO:0007063)2.58996201
134mitotic nuclear envelope disassembly (GO:0007077)2.58574886
135regulation of translational initiation (GO:0006446)2.58500465
136NLS-bearing protein import into nucleus (GO:0006607)2.57780111
137epithelial cell-cell adhesion (GO:0090136)2.57718485
138signal peptide processing (GO:0006465)2.55002896
139DNA conformation change (GO:0071103)2.54215098
140snRNA processing (GO:0016180)2.53962326
141telomere maintenance (GO:0000723)2.53933853
142telomere maintenance via recombination (GO:0000722)2.53722343
143regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.53632673
144chromosome segregation (GO:0007059)2.53510037
145mRNA export from nucleus (GO:0006406)2.53150205
146replicative senescence (GO:0090399)2.51734495
147regulation of mitotic sister chromatid separation (GO:0010965)2.51207098
148regulation of mitotic sister chromatid segregation (GO:0033047)2.51207098
149regulation of sister chromatid segregation (GO:0033045)2.51207098
150spindle assembly checkpoint (GO:0071173)2.50983043
151embryonic process involved in female pregnancy (GO:0060136)2.50572279
152mismatch repair (GO:0006298)2.50316513
153positive regulation of epidermal cell differentiation (GO:0045606)2.50299209
154somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50274810
155somatic hypermutation of immunoglobulin genes (GO:0016446)2.50274810
156termination of RNA polymerase I transcription (GO:0006363)2.50005812
157cytoplasmic mRNA processing body assembly (GO:0033962)2.49817092
158regulation of mammary gland epithelial cell proliferation (GO:0033599)2.49708999
159ectodermal placode formation (GO:0060788)2.49438692
160insulin-like growth factor receptor signaling pathway (GO:0048009)2.49221929
161telomere organization (GO:0032200)2.49027344
162regulation of G0 to G1 transition (GO:0070316)2.48522554
163IMP metabolic process (GO:0046040)2.48138102
164cellular response to gamma radiation (GO:0071480)2.47931592
165positive regulation of cellular response to insulin stimulus (GO:1900078)2.47562512
166telomere maintenance via telomerase (GO:0007004)2.47378844
167mitotic spindle checkpoint (GO:0071174)2.47348649
168sarcomere organization (GO:0045214)2.46677298
169sister chromatid segregation (GO:0000819)2.46447086
170DNA replication checkpoint (GO:0000076)2.46207864
171protein K11-linked ubiquitination (GO:0070979)2.46070802
172dosage compensation (GO:0007549)2.45074769
173branching involved in mammary gland duct morphogenesis (GO:0060444)2.44409925
174dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44190496
175maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.44108098
176trophectodermal cell differentiation (GO:0001829)2.43989989
177nuclear envelope disassembly (GO:0051081)2.43736472
178membrane disassembly (GO:0030397)2.43736472
179intracellular estrogen receptor signaling pathway (GO:0030520)2.43592337
180regulation of mRNA stability (GO:0043488)2.43320703
181negative regulation of organelle assembly (GO:1902116)2.43085063
182negative regulation of cell size (GO:0045792)2.41140987
183proline biosynthetic process (GO:0006561)2.36797795
184NADH metabolic process (GO:0006734)2.36695362
185chromosome condensation (GO:0030261)2.36348042
186hepatocyte apoptotic process (GO:0097284)2.35683593
187negative regulation of skeletal muscle tissue development (GO:0048642)2.33287413
188mitotic sister chromatid segregation (GO:0000070)2.31226133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.47435520
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.43222174
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.45504627
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38348126
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.31530155
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29854818
7ESR1_15608294_ChIP-ChIP_MCF-7_Human3.08775197
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.97859461
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.91227114
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82859539
11ZNF263_19887448_ChIP-Seq_K562_Human2.72994558
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68037969
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.56406008
14CLOCK_20551151_ChIP-Seq_293T_Human2.55018192
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.52145093
16ELK1_19687146_ChIP-ChIP_HELA_Human2.49478467
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42520025
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38497985
19ZFX_18555785_ChIP-Seq_MESCs_Mouse2.36839722
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26478065
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.18213043
22* EST1_17652178_ChIP-ChIP_JURKAT_Human2.15576814
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.12761389
24HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12288399
25* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12233982
26* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.11228377
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09932447
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08206533
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04482233
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.04285794
31GABP_17652178_ChIP-ChIP_JURKAT_Human2.01779273
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97353090
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95825425
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94501567
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92008274
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.91139204
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90938955
38EWS_26573619_Chip-Seq_HEK293_Human1.89883815
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.87306950
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.82927454
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81177271
42* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77088400
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76681407
44* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76057170
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75506330
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.73664047
47* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72511145
48* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72325282
49* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71842377
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.71460306
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70861785
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69992392
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.68799903
54* CHD1_26751641_Chip-Seq_LNCaP_Human1.67507288
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66025414
56FUS_26573619_Chip-Seq_HEK293_Human1.65872088
57* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65732190
58* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64204597
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60207287
60* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59784304
61MYC_22102868_ChIP-Seq_BL_Human1.54261946
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52552768
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52504110
64* VDR_23849224_ChIP-Seq_CD4+_Human1.51572531
65* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49157956
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.48288582
67* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45331186
68* MYC_18555785_ChIP-Seq_MESCs_Mouse1.45325323
69* RUNX1_27514584_Chip-Seq_MCF-7_Human1.45131446
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43676374
71* XRN2_22483619_ChIP-Seq_HELA_Human1.42112205
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41421347
73* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41350650
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40930075
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40752547
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40127172
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40065130
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38737203
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38274822
80FOXP3_21729870_ChIP-Seq_TREG_Human1.35710635
81* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31323095
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.30108226
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29367832
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28929852
85AHR_22903824_ChIP-Seq_MCF-7_Human1.28422958
86* RACK7_27058665_Chip-Seq_MCF-7_Human1.27731289
87AR_21909140_ChIP-Seq_LNCAP_Human1.27578105
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27052635
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.25637991
90* GATA3_24758297_ChIP-Seq_MCF-7_Human1.25509954
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.23915809
92* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23615179
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22735125
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22735125
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22735125
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21438202
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21421235
98* KDM5A_27292631_Chip-Seq_BREAST_Human1.20581879
99* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20260026
100* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19644913
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.18858927
102* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18597070
103ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17377616
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17074147
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.16985930
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16812398
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15926146
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15624091
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14601316
110GATA4_21415370_ChIP-Seq_HL-1_Mouse1.13644161
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12172753
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.12051333
113* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12014746
114SOX17_20123909_ChIP-Seq_XEN_Mouse1.11760832
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09986973
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09156397
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08927057
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08426792
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.08063790
120CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07797028
121TCF7_22412390_ChIP-Seq_EML_Mouse1.07527088
122P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07085071
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.06125290
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05658170
125FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04987296
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04929586
127* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04915109
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04630365
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04340620
130* TFEB_21752829_ChIP-Seq_HELA_Human1.03839013
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.03135446
132DCP1A_22483619_ChIP-Seq_HELA_Human1.02754905
133P53_22387025_ChIP-Seq_ESCs_Mouse1.02171889
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01713166
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01199704
136IRF1_19129219_ChIP-ChIP_H3396_Human1.00154263
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99989970
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99334890
139SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99292230
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98925293
141P300_19829295_ChIP-Seq_ESCs_Human0.98435339
142SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98121688
143E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96567288
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96526784
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95679224
146NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95675581
147POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95598935
148NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95312492
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95027660
150IRF8_21731497_ChIP-ChIP_J774_Mouse0.94652909
151P300_18555785_Chip-Seq_ESCs_Mouse0.92154778
152SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92009768
153SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92009768
154SOX9_26525672_Chip-Seq_HEART_Mouse0.91814936
155FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91152651
156HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91068634
157TTF2_22483619_ChIP-Seq_HELA_Human0.90721173
158SALL4_22934838_ChIP-ChIP_CD34+_Human0.90531870
159BRD4_25478319_ChIP-Seq_HGPS_Human0.90179686
160* ER_23166858_ChIP-Seq_MCF-7_Human0.90149154
161NMYC_18555785_Chip-Seq_ESCs_Mouse0.89760705
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88492242
163OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87945364
164NANOG_16153702_ChIP-ChIP_HESCs_Human0.87359975
165* ETS1_20019798_ChIP-Seq_JURKAT_Human0.87325160
166* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86894679
167SOX2_18555785_Chip-Seq_ESCs_Mouse0.86844431
168OCT4_18555785_Chip-Seq_ESCs_Mouse0.85381836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.63899472
2MP0003705_abnormal_hypodermis_morpholog3.51770840
3MP0010094_abnormal_chromosome_stability3.38184770
4MP0010234_abnormal_vibrissa_follicle3.16912115
5MP0008007_abnormal_cellular_replicative3.07336636
6MP0008058_abnormal_DNA_repair2.94933023
7MP0003787_abnormal_imprinting2.88925176
8MP0005076_abnormal_cell_differentiation2.82686898
9MP0008877_abnormal_DNA_methylation2.76027753
10MP0004233_abnormal_muscle_weight2.72874149
11MP0003121_genomic_imprinting2.62587956
12MP0009697_abnormal_copulation2.56863692
13MP0003077_abnormal_cell_cycle2.51406188
14MP0003943_abnormal_hepatobiliary_system2.26909894
15MP0003111_abnormal_nucleus_morphology2.26441882
16MP0003123_paternal_imprinting2.25391661
17MP0003693_abnormal_embryo_hatching2.22766005
18MP0010352_gastrointestinal_tract_polyps2.21527856
19MP0009672_abnormal_birth_weight2.20568729
20MP0005367_renal/urinary_system_phenotyp2.17440102
21MP0000516_abnormal_urinary_system2.17440102
22MP0001188_hyperpigmentation2.13277151
23MP0004185_abnormal_adipocyte_glucose2.05373314
24MP0009780_abnormal_chondrocyte_physiolo2.05306169
25MP0002796_impaired_skin_barrier2.04348667
26MP0002396_abnormal_hematopoietic_system2.00695710
27MP0000015_abnormal_ear_pigmentation1.97270621
28MP0003941_abnormal_skin_development1.96222336
29MP0004264_abnormal_extraembryonic_tissu1.94336342
30MP0000537_abnormal_urethra_morphology1.91823131
31MP0005503_abnormal_tendon_morphology1.88694714
32MP0003221_abnormal_cardiomyocyte_apopto1.83980048
33MP0000751_myopathy1.77776072
34MP0004782_abnormal_surfactant_physiolog1.72800431
35MP0004957_abnormal_blastocyst_morpholog1.71278892
36MP0010678_abnormal_skin_adnexa1.70548502
37MP0003786_premature_aging1.69780871
38MP0000569_abnormal_digit_pigmentation1.67147522
39MP0001879_abnormal_lymphatic_vessel1.66193542
40MP0006292_abnormal_olfactory_placode1.63827461
41MP0003122_maternal_imprinting1.63421805
42MP0005451_abnormal_body_composition1.62015742
43MP0004087_abnormal_muscle_fiber1.60114675
44MP0002163_abnormal_gland_morphology1.55513046
45MP0000566_synostosis1.52322569
46MP0001177_atelectasis1.51715039
47MP0005171_absent_coat_pigmentation1.50925475
48MP0005501_abnormal_skin_physiology1.50188114
49MP0003942_abnormal_urinary_system1.49771163
50MP0000383_abnormal_hair_follicle1.49408608
51MP0005408_hypopigmentation1.48123617
52MP0009703_decreased_birth_body1.47946412
53MP0003566_abnormal_cell_adhesion1.43964332
54MP0010630_abnormal_cardiac_muscle1.43948915
55MP0001727_abnormal_embryo_implantation1.43880337
56MP0009250_abnormal_appendicular_skeleto1.43880230
57MP0003890_abnormal_embryonic-extraembry1.42733967
58MP0002009_preneoplasia1.39533904
59MP0002132_abnormal_respiratory_system1.39303401
60MP0008932_abnormal_embryonic_tissue1.38283677
61MP0004808_abnormal_hematopoietic_stem1.37603697
62MP0004084_abnormal_cardiac_muscle1.37480899
63MP0000747_muscle_weakness1.37322307
64MP0004134_abnormal_chest_morphology1.35905397
65MP0002080_prenatal_lethality1.34846404
66MP0002084_abnormal_developmental_patter1.34566190
67MP0009053_abnormal_anal_canal1.34215945
68MP0002269_muscular_atrophy1.33649318
69MP0000462_abnormal_digestive_system1.33287309
70MP0002938_white_spotting1.32625224
71MP0002085_abnormal_embryonic_tissue1.31085981
72MP0001119_abnormal_female_reproductive1.27589553
73MP0002697_abnormal_eye_size1.25877333
74MP0001849_ear_inflammation1.25225499
75MP0003385_abnormal_body_wall1.22948693
76MP0006054_spinal_hemorrhage1.22878425
77MP0000733_abnormal_muscle_development1.21888302
78MP0005646_abnormal_pituitary_gland1.21335353
79MP0008438_abnormal_cutaneous_collagen1.20515616
80MP0006138_congestive_heart_failure1.19849652
81MP0000377_abnormal_hair_follicle1.19641977
82MP0002876_abnormal_thyroid_physiology1.17577824
83MP0000372_irregular_coat_pigmentation1.17028975
84MP0000759_abnormal_skeletal_muscle1.16673562
85MP0004036_abnormal_muscle_relaxation1.16345121
86MP0000750_abnormal_muscle_regeneration1.15902100
87MP0005666_abnormal_adipose_tissue1.15821920
88MP0000627_abnormal_mammary_gland1.11706810
89MP0010030_abnormal_orbit_morphology1.11664500
90MP0000579_abnormal_nail_morphology1.11217479
91MP0002210_abnormal_sex_determination1.10551891
92MP0003755_abnormal_palate_morphology1.09973144
93MP0002098_abnormal_vibrissa_morphology1.08622734
94MP0003937_abnormal_limbs/digits/tail_de1.07765999
95MP0002877_abnormal_melanocyte_morpholog1.07686155
96MP0000678_abnormal_parathyroid_gland1.05721911
97MP0005389_reproductive_system_phenotype1.05507572
98MP0010307_abnormal_tumor_latency1.05327674
99MP0002160_abnormal_reproductive_system1.05090572
100MP0003984_embryonic_growth_retardation1.04335884
101MP0000749_muscle_degeneration1.03817749
102MP0000350_abnormal_cell_proliferation1.03545953
103MP0008260_abnormal_autophagy1.02656237
104MP0005380_embryogenesis_phenotype1.01634674
105MP0001672_abnormal_embryogenesis/_devel1.01634674
106MP0004147_increased_porphyrin_level0.98841897
107MP0002088_abnormal_embryonic_growth/wei0.98749315
108MP0005409_darkened_coat_color0.98658596
109MP0002095_abnormal_skin_pigmentation0.97740518
110MP0000049_abnormal_middle_ear0.96895851
111MP0001286_abnormal_eye_development0.95613797
112MP0002092_abnormal_eye_morphology0.95473791
113MP0003567_abnormal_fetal_cardiomyocyte0.93807435
114MP0003315_abnormal_perineum_morphology0.93251285
115MP0005248_abnormal_Harderian_gland0.91990250
116MP0001186_pigmentation_phenotype0.91818004
117MP0002282_abnormal_trachea_morphology0.90134136
118MP0005621_abnormal_cell_physiology0.89352441
119MP0002109_abnormal_limb_morphology0.88730132
120MP0005508_abnormal_skeleton_morphology0.88644807
121MP0002108_abnormal_muscle_morphology0.88552224
122MP0002060_abnormal_skin_morphology0.84759999
123MP0000467_abnormal_esophagus_morphology0.84114238
124MP0005375_adipose_tissue_phenotype0.83537650
125MP0003453_abnormal_keratinocyte_physiol0.83173763
126MP0004197_abnormal_fetal_growth/weight/0.83143492
127MP0008995_early_reproductive_senescence0.82623949
128MP0000428_abnormal_craniofacial_morphol0.82598474
129MP0001835_abnormal_antigen_presentation0.82286633
130MP0001697_abnormal_embryo_size0.81755204
131MP0000681_abnormal_thyroid_gland0.81630038
132MP0002249_abnormal_larynx_morphology0.80756834
133MP0003115_abnormal_respiratory_system0.80378679
134MP0005384_cellular_phenotype0.80037279
135MP0001919_abnormal_reproductive_system0.80030726
136MP0003935_abnormal_craniofacial_develop0.79767457
137MP0005084_abnormal_gallbladder_morpholo0.79720669
138MP0002896_abnormal_bone_mineralization0.79226912
139MP0005330_cardiomyopathy0.79019891
140MP0001915_intracranial_hemorrhage0.78670941
141MP0000534_abnormal_ureter_morphology0.78467238
142MP0000003_abnormal_adipose_tissue0.78154344
143MP0003828_pulmonary_edema0.77388377
144MP0002106_abnormal_muscle_physiology0.76414472
145MP0001175_abnormal_lung_morphology0.75272347
146MP0000427_abnormal_hair_cycle0.74862811
147MP0000767_abnormal_smooth_muscle0.74777873
148MP0001340_abnormal_eyelid_morphology0.74625332
149MP0005369_muscle_phenotype0.74589905
150MP0000266_abnormal_heart_morphology0.73260876
151MP0001730_embryonic_growth_arrest0.73218521
152MP0010368_abnormal_lymphatic_system0.73009202
153MP0001299_abnormal_eye_distance/0.72200266
154MP0002233_abnormal_nose_morphology0.72099829
155MP0002177_abnormal_outer_ear0.71378274
156MP0000653_abnormal_sex_gland0.71218050
157MP0005379_endocrine/exocrine_gland_phen0.71215988
158MP0002086_abnormal_extraembryonic_tissu0.71041628
159MP0000313_abnormal_cell_death0.70452221
160MP0002277_abnormal_respiratory_mucosa0.69857826
161MP0001145_abnormal_male_reproductive0.69723432
162MP0002133_abnormal_respiratory_system0.69678057
163MP0005388_respiratory_system_phenotype0.69678057
164MP0002332_abnormal_exercise_endurance0.69525507
165MP0003950_abnormal_plasma_membrane0.69491985
166MP0005187_abnormal_penis_morphology0.68365704

Predicted human phenotypes

RankGene SetZ-score
1Spinal cord lesions (HP:0100561)3.99132381
2Syringomyelia (HP:0003396)3.99132381
3Chromsome breakage (HP:0040012)3.82599257
4Microglossia (HP:0000171)3.79106219
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.70921745
6Abnormality of incisor morphology (HP:0011063)3.39467371
7Insidious onset (HP:0003587)3.38673718
8Termporal pattern (HP:0011008)3.38673718
9Embryonal renal neoplasm (HP:0011794)3.36182845
10Nephroblastoma (Wilms tumor) (HP:0002667)3.34915545
11Abnormal hair whorl (HP:0010721)3.32288027
12Asymmetry of the thorax (HP:0001555)3.19995752
13Papillary thyroid carcinoma (HP:0002895)3.15574392
14Hyperacusis (HP:0010780)3.11159793
15Abnormal lung lobation (HP:0002101)3.08343469
16Deep philtrum (HP:0002002)3.07814085
17True hermaphroditism (HP:0010459)2.93498979
18J-shaped sella turcica (HP:0002680)2.89956396
1911 pairs of ribs (HP:0000878)2.83202134
20Long clavicles (HP:0000890)2.82947502
21Septate vagina (HP:0001153)2.65694730
22Birth length less than 3rd percentile (HP:0003561)2.65029274
23Thyroid carcinoma (HP:0002890)2.60762413
24Cutaneous melanoma (HP:0012056)2.58039618
25Abnormality of the nasal septum (HP:0000419)2.57254678
26Meckel diverticulum (HP:0002245)2.56135409
27Exercise-induced muscle cramps (HP:0003710)2.54857435
28Back pain (HP:0003418)2.50772308
29Abnormal pancreas size (HP:0012094)2.47939066
30Abnormality of chromosome stability (HP:0003220)2.47849283
31Uterine leiomyosarcoma (HP:0002891)2.47083648
32Leiomyosarcoma (HP:0100243)2.47083648
33Right ventricular cardiomyopathy (HP:0011663)2.43023846
34Breast carcinoma (HP:0003002)2.41485006
35Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.40601916
36Abnormality of the ileum (HP:0001549)2.39229483
37Nemaline bodies (HP:0003798)2.39150599
38Increased nuchal translucency (HP:0010880)2.36442941
39Abnormality of the anterior horn cell (HP:0006802)2.35780001
40Degeneration of anterior horn cells (HP:0002398)2.35780001
41Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.34373186
42Hyporeflexia of lower limbs (HP:0002600)2.34337279
43Germ cell neoplasia (HP:0100728)2.33904218
44Dysmetric saccades (HP:0000641)2.33227652
45Irregular epiphyses (HP:0010582)2.32777465
46Ectopic kidney (HP:0000086)2.32140068
47Cystic hygroma (HP:0000476)2.31132564
48Muscle fiber inclusion bodies (HP:0100299)2.31112224
49Malignant gastrointestinal tract tumors (HP:0006749)2.29585999
50Gastrointestinal carcinoma (HP:0002672)2.29585999
51Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.29366124
52Micronodular cirrhosis (HP:0001413)2.28678624
53Volvulus (HP:0002580)2.28075796
54Exercise-induced myalgia (HP:0003738)2.27660761
55Patellar aplasia (HP:0006443)2.25927266
56Fibular hypoplasia (HP:0003038)2.24585866
57Diastasis recti (HP:0001540)2.24054183
58Pancreatic fibrosis (HP:0100732)2.23512067
59Distal lower limb muscle weakness (HP:0009053)2.23492119
60Meningioma (HP:0002858)2.23001757
61Alveolar cell carcinoma (HP:0006519)2.20456521
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.19351046
63Absent frontal sinuses (HP:0002688)2.19194003
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18800346
65Renal cortical cysts (HP:0000803)2.18532175
66Cortical dysplasia (HP:0002539)2.18166826
67Insomnia (HP:0100785)2.17807396
68Abnormality of the left ventricular outflow tract (HP:0011103)2.17281576
69Subaortic stenosis (HP:0001682)2.17281576
70Abnormality of the incisor (HP:0000676)2.16706340
71Neoplasm of the adrenal cortex (HP:0100641)2.16701253
72Mesomelia (HP:0003027)2.16663139
73Transitional cell carcinoma of the bladder (HP:0006740)2.14330036
74Shawl scrotum (HP:0000049)2.13881762
75Tubulointerstitial nephritis (HP:0001970)2.12480028
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.11895608
77Hepatoblastoma (HP:0002884)2.11696228
78Abnormality of the intervertebral disk (HP:0005108)2.10882535
79Abnormality of the preputium (HP:0100587)2.10289591
80Deformed sella turcica (HP:0002681)2.09567377
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08777983
82Short 4th metacarpal (HP:0010044)2.08777983
83Optic nerve coloboma (HP:0000588)2.08015727
84Aplasia/Hypoplasia of the patella (HP:0006498)2.05677275
85Flat capital femoral epiphysis (HP:0003370)2.05147611
86Macroorchidism (HP:0000053)2.02399506
87Bundle branch block (HP:0011710)2.02083648
88Medulloblastoma (HP:0002885)2.01757581
89Distal lower limb amyotrophy (HP:0008944)2.00792801
90Bladder carcinoma (HP:0002862)2.00750620
91Bladder neoplasm (HP:0009725)2.00750620
92Shoulder girdle muscle weakness (HP:0003547)2.00545117
93Neonatal hypoglycemia (HP:0001998)1.99925799
94Acute myeloid leukemia (HP:0004808)1.99172159
95Neoplasm of the thyroid gland (HP:0100031)1.98529188
96Small intestinal stenosis (HP:0012848)1.97912559
97Duodenal stenosis (HP:0100867)1.97912559
98Overriding aorta (HP:0002623)1.97727918
99Myelodysplasia (HP:0002863)1.96489871
100Pelvic girdle muscle weakness (HP:0003749)1.95855814
101Flat acetabular roof (HP:0003180)1.95718824
102Absent eyebrow (HP:0002223)1.95085995
103Chronic hepatic failure (HP:0100626)1.94137459
104Keratoconjunctivitis sicca (HP:0001097)1.93296746
105Abnormality of the fingertips (HP:0001211)1.93078768
106Hypoplastic left heart (HP:0004383)1.91953068
107Hypopigmentation of the fundus (HP:0007894)1.91190606
108Increased connective tissue (HP:0009025)1.91108821
109Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90773626
110Aplastic anemia (HP:0001915)1.88906437
111Type I transferrin isoform profile (HP:0003642)1.88644267
112Mildly elevated creatine phosphokinase (HP:0008180)1.86935981
113Curly hair (HP:0002212)1.86365223
114Progressive external ophthalmoplegia (HP:0000590)1.86182208
115Abnormality of the calcaneus (HP:0008364)1.85644634
116Preaxial hand polydactyly (HP:0001177)1.85160691
117Facial cleft (HP:0002006)1.85009412
118Enlarged kidneys (HP:0000105)1.83923833
119Neoplasm of the tracheobronchial system (HP:0100552)1.82125781
120Postaxial foot polydactyly (HP:0001830)1.81947341
121Progressive muscle weakness (HP:0003323)1.80587253
122Vitreoretinal degeneration (HP:0000655)1.79790591
123Renal cell carcinoma (HP:0005584)1.77177198
124Pancreatic islet-cell hyperplasia (HP:0004510)1.77060000
125Metaphyseal dysplasia (HP:0100255)1.76762222
126Poor coordination (HP:0002370)1.76596070
127Elfin facies (HP:0004428)1.75918752
128Adrenal hypoplasia (HP:0000835)1.75825713
129Neoplasm of the adrenal gland (HP:0100631)1.75793957
130Aplasia/Hypoplasia of the sternum (HP:0006714)1.75250879
131Bone marrow hypocellularity (HP:0005528)1.74768340
132Rimmed vacuoles (HP:0003805)1.74196644
133Breech presentation (HP:0001623)1.73866709
134Keratoconjunctivitis (HP:0001096)1.73774406
135Prostate neoplasm (HP:0100787)1.73134464
136Hypoplastic heart (HP:0001961)1.72958898
137Heterotopia (HP:0002282)1.72705685
138Abnormality of the nasolacrimal system (HP:0000614)1.72453422
139Renovascular hypertension (HP:0100817)1.72075361
140Capillary hemangiomas (HP:0005306)1.71984727
141Mild short stature (HP:0003502)1.71901779
142Progressive sensorineural hearing impairment (HP:0000408)1.71827559
143Optic neuritis (HP:0100653)1.71283604
144Retrobulbar optic neuritis (HP:0100654)1.71283604
145Impulsivity (HP:0100710)1.71165181
146Uterine neoplasm (HP:0010784)1.70767373
147Abnormality of the hip-girdle musculature (HP:0001445)1.70601342
148Abnormality of the musculature of the pelvis (HP:0001469)1.70601342
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.69329502
150Embryonal neoplasm (HP:0002898)1.68952241
151Multiple enchondromatosis (HP:0005701)1.68915049
152Sudden death (HP:0001699)1.68688125
153Sparse lateral eyebrow (HP:0005338)1.67199679
154Spastic diplegia (HP:0001264)1.66655510
155Hypoplastic iliac wings (HP:0002866)1.66305545
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66049508
157Absent epiphyses (HP:0010577)1.66049508
158Abnormality of the femoral head (HP:0003368)1.65745846
159Sloping forehead (HP:0000340)1.65580984
160Deviation of the thumb (HP:0009603)1.65511113
161Testicular neoplasm (HP:0010788)1.65350350
162Abnormality of the renal collecting system (HP:0004742)1.65045198
163Type 1 muscle fiber predominance (HP:0003803)1.63729084
164Clubbing of toes (HP:0100760)1.63570854
165Cafe-au-lait spot (HP:0000957)1.63466352
166Advanced eruption of teeth (HP:0006288)1.63113707
167Abnormality of the frontal sinuses (HP:0002687)1.62682276
168Esophageal varix (HP:0002040)1.61843800
169Abnormality of the epiphysis of the femoral head (HP:0010574)1.61736172
170Vertebral arch anomaly (HP:0008438)1.61475340
171High anterior hairline (HP:0009890)1.60727742
172Abnormality of the umbilical cord (HP:0010881)1.60446828
173Osteolytic defects of the phalanges of the hand (HP:0009771)1.59884593
174Osteolytic defects of the hand bones (HP:0009699)1.59884593
175Patellar dislocation (HP:0002999)1.59716331
176Proximal placement of thumb (HP:0009623)1.58493021
177Calcaneovalgus deformity (HP:0001848)1.54936921
178Renal duplication (HP:0000075)1.54227664
179Rhabdomyosarcoma (HP:0002859)1.54009037
180Exostoses (HP:0100777)1.53431602
181Lower limb amyotrophy (HP:0007210)1.52518835
182EMG: neuropathic changes (HP:0003445)1.52445247

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL24.80880300
2TRIB34.42855259
3PKN23.38593460
4EEF2K3.33013431
5ERBB33.16872930
6ZAK2.96447665
7AKT32.95050849
8RPS6KB22.83897853
9SRPK12.63759992
10BRSK22.49086214
11STK38L2.40582368
12MKNK12.23697624
13SIK32.19787348
14PLK32.16984507
15SMG12.16042186
16TTN2.09543210
17SGK22.06362594
18MAP3K102.03603025
19FRK2.03308054
20PBK2.03229081
21CDK122.02224137
22SIK12.01065231
23NEK91.98157126
24TSSK61.93940828
25BMPR1B1.92592885
26MKNK21.88716362
27EIF2AK11.85772230
28PLK41.85168834
29MAP3K141.83116982
30CASK1.80754714
31STK241.79248023
32NUAK11.76426662
33ACVR1B1.75527032
34PRPF4B1.74295569
35CDC71.73992600
36PDGFRA1.72341069
37PLK21.69191811
38LATS21.64433973
39YES11.63375975
40BMPR21.60980043
41CDK81.56956479
42FGFR41.53024903
43ICK1.50958526
44TGFBR11.50743574
45CLK11.50248796
46TRPM71.46140017
47CCNB11.42306916
48IRAK41.42093081
49CDK61.41427235
50BCR1.39900590
51IRAK31.35853860
52NEK61.35201397
53BRSK11.35014604
54PASK1.34075818
55PAK41.33154566
56EIF2AK31.32887368
57VRK11.25918580
58EIF2AK21.25527579
59TXK1.23277782
60BUB11.19910490
61MAPKAPK31.18481411
62SGK31.17410865
63ATR1.14941926
64OBSCN1.14917567
65MTOR1.14360429
66KSR11.14163729
67KSR21.12726940
68MUSK1.12390014
69WEE11.02237763
70MYLK1.01757165
71STK30.99590191
72SGK4940.99203622
73SGK2230.99203622
74PIK3CA0.99182571
75RPS6KB10.98319360
76PLK10.97950020
77CHUK0.96561736
78EPHA20.95472875
79TRIM280.93995363
80RET0.91876680
81TAOK20.91477854
82DMPK0.89970319
83MAPK130.89132190
84LATS10.88440133
85TAF10.87002599
86MAP3K30.84986165
87MAP2K70.82685753
88PTK60.81895617
89RIPK10.81457313
90MAP3K90.79402735
91BRD40.78879529
92MST40.76711882
93PDK20.76494096
94TEC0.74784041
95ATM0.74716206
96ALK0.73343349
97AURKB0.71951499
98AKT20.70212545
99NEK10.69708283
100STK40.69676958
101ILK0.68339078
102TTK0.67472109
103RPS6KA60.66987707
104RPS6KC10.66713453
105RPS6KL10.66713453
106MAP2K20.66626973
107TIE10.65047558
108STK160.64073826
109CHEK20.63861579
110FGFR30.63716485
111PAK20.61470173
112CHEK10.60046005
113MAP3K120.59781340
114PDK30.57931106
115PDK40.57931106
116MAP2K30.56195682
117BRAF0.54861064
118CDK40.52945349
119CDK70.52582671
120MAP3K20.49362655
121RPS6KA20.47733385
122MAP2K10.47405853
123PIM10.47377380
124MAPK100.46818891
125CDK30.46393996
126PNCK0.46372992
127FGFR10.45488997
128CSNK2A10.44999040
129CDK10.43455008
130EPHA30.42387493
131CSNK1E0.41798835
132MARK30.41687782
133CDK180.41613944
134IRAK20.41236940
135CAMK2B0.40648624
136CAMK1G0.40460474
137CAMK2G0.38483068
138RPS6KA40.37839790
139PTK20.37625678
140JAK30.36527017
141DYRK30.36191926
142DYRK1B0.36128127
143CDK150.35272329
144PDGFRB0.34168258
145FGFR20.34121799
146AURKA0.33593164
147TESK10.33440823
148ADRBK20.33019216
149MAPK140.32567462
150CDK20.32544891
151RPS6KA10.32530220
152MAP3K60.32160374
153DYRK20.30746463
154MELK0.27344101
155IKBKB0.26355996
156PIM20.23568237

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.13764881
2Base excision repair_Homo sapiens_hsa034103.12609980
3DNA replication_Homo sapiens_hsa030303.06780323
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05346950
5Basal transcription factors_Homo sapiens_hsa030222.82000025
6Cell cycle_Homo sapiens_hsa041102.78473627
7Homologous recombination_Homo sapiens_hsa034402.73522016
8RNA polymerase_Homo sapiens_hsa030202.65198476
9Fanconi anemia pathway_Homo sapiens_hsa034602.55536032
10Nucleotide excision repair_Homo sapiens_hsa034202.50697468
11Non-homologous end-joining_Homo sapiens_hsa034502.47145085
12RNA degradation_Homo sapiens_hsa030182.44219697
13Protein export_Homo sapiens_hsa030602.33672825
14RNA transport_Homo sapiens_hsa030132.20714191
15Proteasome_Homo sapiens_hsa030502.16543043
16Spliceosome_Homo sapiens_hsa030402.10407488
17mRNA surveillance pathway_Homo sapiens_hsa030151.95922063
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.93852455
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.88939002
20One carbon pool by folate_Homo sapiens_hsa006701.87986832
21Chronic myeloid leukemia_Homo sapiens_hsa052201.86198684
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78261725
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.76864002
24Renal cell carcinoma_Homo sapiens_hsa052111.62919697
25Pentose phosphate pathway_Homo sapiens_hsa000301.60447854
26Pyrimidine metabolism_Homo sapiens_hsa002401.55663353
27mTOR signaling pathway_Homo sapiens_hsa041501.52943831
28Insulin signaling pathway_Homo sapiens_hsa049101.48747161
29Glioma_Homo sapiens_hsa052141.48482486
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48480077
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.48363807
32Biosynthesis of amino acids_Homo sapiens_hsa012301.47691169
33AMPK signaling pathway_Homo sapiens_hsa041521.46996829
34Acute myeloid leukemia_Homo sapiens_hsa052211.41771000
35ErbB signaling pathway_Homo sapiens_hsa040121.41314116
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39473053
37Tight junction_Homo sapiens_hsa045301.32784174
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30354082
39Carbon metabolism_Homo sapiens_hsa012001.27688486
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27408997
41Bladder cancer_Homo sapiens_hsa052191.25844766
42Purine metabolism_Homo sapiens_hsa002301.25359224
43Legionellosis_Homo sapiens_hsa051341.24334120
44Herpes simplex infection_Homo sapiens_hsa051681.23154058
45Epstein-Barr virus infection_Homo sapiens_hsa051691.22955047
46p53 signaling pathway_Homo sapiens_hsa041151.21248455
47Proteoglycans in cancer_Homo sapiens_hsa052051.14808821
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13808334
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13561305
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13384232
51Thyroid cancer_Homo sapiens_hsa052161.12868259
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10157090
53Prolactin signaling pathway_Homo sapiens_hsa049171.10062515
54VEGF signaling pathway_Homo sapiens_hsa043701.06406137
55Lysine degradation_Homo sapiens_hsa003101.05813984
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05078859
57Estrogen signaling pathway_Homo sapiens_hsa049151.04936916
58Measles_Homo sapiens_hsa051621.04091383
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.03253720
60Inositol phosphate metabolism_Homo sapiens_hsa005621.02137881
61Choline metabolism in cancer_Homo sapiens_hsa052311.01168367
62Dilated cardiomyopathy_Homo sapiens_hsa054141.00596741
63Allograft rejection_Homo sapiens_hsa053301.00256222
64Influenza A_Homo sapiens_hsa051640.96978202
65TGF-beta signaling pathway_Homo sapiens_hsa043500.95301737
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94846933
67Arachidonic acid metabolism_Homo sapiens_hsa005900.94035116
68MicroRNAs in cancer_Homo sapiens_hsa052060.92461478
69Adherens junction_Homo sapiens_hsa045200.89198505
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.87783584
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87196430
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87054112
73Viral carcinogenesis_Homo sapiens_hsa052030.86353275
74Insulin resistance_Homo sapiens_hsa049310.85989571
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85145431
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83165739
77Glucagon signaling pathway_Homo sapiens_hsa049220.82306460
78HTLV-I infection_Homo sapiens_hsa051660.80876868
79Autoimmune thyroid disease_Homo sapiens_hsa053200.80611761
80Viral myocarditis_Homo sapiens_hsa054160.79704941
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78774017
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78752189
83Fructose and mannose metabolism_Homo sapiens_hsa000510.78055905
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77220267
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74174763
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.71807873
87Gap junction_Homo sapiens_hsa045400.71730654
88Long-term potentiation_Homo sapiens_hsa047200.70581731
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70139641
90Prostate cancer_Homo sapiens_hsa052150.69687779
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67619259
92Hippo signaling pathway_Homo sapiens_hsa043900.67379120
93Oocyte meiosis_Homo sapiens_hsa041140.67190368
94Phagosome_Homo sapiens_hsa041450.66405304
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63734168
96Small cell lung cancer_Homo sapiens_hsa052220.63669327
97FoxO signaling pathway_Homo sapiens_hsa040680.60276339
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60242971
99Melanoma_Homo sapiens_hsa052180.59309759
100Graft-versus-host disease_Homo sapiens_hsa053320.59002266
101Melanogenesis_Homo sapiens_hsa049160.58972666
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58951810
103Endometrial cancer_Homo sapiens_hsa052130.58696743
104Notch signaling pathway_Homo sapiens_hsa043300.58019348
105Antigen processing and presentation_Homo sapiens_hsa046120.57421045
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56981901
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56829254
108N-Glycan biosynthesis_Homo sapiens_hsa005100.56722641
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55279268
110Leishmaniasis_Homo sapiens_hsa051400.54715814
111Systemic lupus erythematosus_Homo sapiens_hsa053220.54101107
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.53239321
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.52421046
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52089914
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51687237
116Hepatitis B_Homo sapiens_hsa051610.51490360
117Circadian rhythm_Homo sapiens_hsa047100.51444692
118Axon guidance_Homo sapiens_hsa043600.50395193
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.49953778
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49888296
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49655000
122ECM-receptor interaction_Homo sapiens_hsa045120.49156609
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48862699
124Type I diabetes mellitus_Homo sapiens_hsa049400.48559362
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48501342
126Toxoplasmosis_Homo sapiens_hsa051450.48315940
127Pyruvate metabolism_Homo sapiens_hsa006200.47860843
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47221944
129GnRH signaling pathway_Homo sapiens_hsa049120.46017448
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45789396
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.45769774
132Apoptosis_Homo sapiens_hsa042100.45588494
133Vibrio cholerae infection_Homo sapiens_hsa051100.44091181
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42992020
135Steroid biosynthesis_Homo sapiens_hsa001000.42214222
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42137059
137Shigellosis_Homo sapiens_hsa051310.41605439
138Focal adhesion_Homo sapiens_hsa045100.40079739
139Pathways in cancer_Homo sapiens_hsa052000.39800634
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39769403
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38589613
142Basal cell carcinoma_Homo sapiens_hsa052170.36103005
143Colorectal cancer_Homo sapiens_hsa052100.35763224
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.35591133
145Pancreatic cancer_Homo sapiens_hsa052120.35184692
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34727670
147Galactose metabolism_Homo sapiens_hsa000520.34088636
148Asthma_Homo sapiens_hsa053100.33630977
149TNF signaling pathway_Homo sapiens_hsa046680.33249578
150Hepatitis C_Homo sapiens_hsa051600.32407911
151Hematopoietic cell lineage_Homo sapiens_hsa046400.31876128
152Huntingtons disease_Homo sapiens_hsa050160.30892565
153HIF-1 signaling pathway_Homo sapiens_hsa040660.29909687
154Malaria_Homo sapiens_hsa051440.27385044
155Rheumatoid arthritis_Homo sapiens_hsa053230.26379410
156Wnt signaling pathway_Homo sapiens_hsa043100.25392257
157Non-small cell lung cancer_Homo sapiens_hsa052230.24058731

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