CSE1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.59484117
2nuclear pore organization (GO:0006999)5.30820059
3protein localization to kinetochore (GO:0034501)5.13811982
4nuclear pore complex assembly (GO:0051292)5.04077115
5mitotic metaphase plate congression (GO:0007080)4.62428567
6DNA replication initiation (GO:0006270)4.59065041
7DNA strand elongation involved in DNA replication (GO:0006271)4.55815819
8mitotic nuclear envelope disassembly (GO:0007077)4.51698262
9protein localization to chromosome, centromeric region (GO:0071459)4.41963924
10kinetochore organization (GO:0051383)4.41157498
11DNA strand elongation (GO:0022616)4.32763037
12mitotic chromosome condensation (GO:0007076)4.29433718
13nuclear envelope disassembly (GO:0051081)4.23101758
14membrane disassembly (GO:0030397)4.23101758
15metaphase plate congression (GO:0051310)4.22104270
16IMP biosynthetic process (GO:0006188)4.21575973
17mitotic sister chromatid segregation (GO:0000070)4.21481776
18sister chromatid segregation (GO:0000819)4.18842133
19DNA replication-dependent nucleosome assembly (GO:0006335)4.18378824
20DNA replication-dependent nucleosome organization (GO:0034723)4.18378824
21mitotic sister chromatid cohesion (GO:0007064)4.14945942
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.14505184
23attachment of spindle microtubules to kinetochore (GO:0008608)4.13765126
24nucleobase biosynthetic process (GO:0046112)4.13322155
25chromatin remodeling at centromere (GO:0031055)4.09014566
26CENP-A containing nucleosome assembly (GO:0034080)4.01821525
27telomere maintenance via semi-conservative replication (GO:0032201)3.97570124
28folic acid-containing compound biosynthetic process (GO:0009396)3.94471972
29purine nucleobase biosynthetic process (GO:0009113)3.92331937
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.91094990
31double-strand break repair via nonhomologous end joining (GO:0006303)3.83753184
32non-recombinational repair (GO:0000726)3.83753184
33pore complex assembly (GO:0046931)3.83283124
34DNA replication checkpoint (GO:0000076)3.83033679
35regulation of spindle organization (GO:0090224)3.81441073
36DNA geometric change (GO:0032392)3.81141404
37DNA duplex unwinding (GO:0032508)3.80226676
38mitotic recombination (GO:0006312)3.79544206
39establishment of chromosome localization (GO:0051303)3.79393536
40DNA replication-independent nucleosome organization (GO:0034724)3.78901470
41DNA replication-independent nucleosome assembly (GO:0006336)3.78901470
42IMP metabolic process (GO:0046040)3.77347531
43kinetochore assembly (GO:0051382)3.73482093
44DNA ligation (GO:0006266)3.69688516
45meiotic chromosome segregation (GO:0045132)3.66629801
46telomere maintenance via recombination (GO:0000722)3.65472293
47establishment of viral latency (GO:0019043)3.64875865
48positive regulation of chromosome segregation (GO:0051984)3.63069910
49formation of translation preinitiation complex (GO:0001731)3.62137768
50spindle checkpoint (GO:0031577)3.56473179
51histone exchange (GO:0043486)3.54969170
52regulation of chromosome segregation (GO:0051983)3.53767633
53regulation of centrosome cycle (GO:0046605)3.53002221
54spindle assembly checkpoint (GO:0071173)3.51752806
55negative regulation of chromosome segregation (GO:0051985)3.49755167
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.49531997
57somatic hypermutation of immunoglobulin genes (GO:0016446)3.49531997
58protein complex localization (GO:0031503)3.49362963
59negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.48032693
60negative regulation of sister chromatid segregation (GO:0033046)3.48032693
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.48032693
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.48032693
63regulation of mitotic metaphase/anaphase transition (GO:0030071)3.45624779
64regulation of histone H3-K9 methylation (GO:0051570)3.43787647
65mitotic spindle assembly checkpoint (GO:0007094)3.43569876
66mitotic spindle checkpoint (GO:0071174)3.41899196
67protein localization to chromosome (GO:0034502)3.39328374
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.38951967
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38951967
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38951967
71ribosome assembly (GO:0042255)3.37393358
72regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36487236
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36136816
74regulation of sister chromatid cohesion (GO:0007063)3.34528393
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.32898146
76pre-miRNA processing (GO:0031054)3.32327037
77regulation of centriole replication (GO:0046599)3.31975949
78telomere maintenance via telomere lengthening (GO:0010833)3.31890059
79regulation of mitotic sister chromatid separation (GO:0010965)3.30688248
80regulation of mitotic sister chromatid segregation (GO:0033047)3.30688248
81regulation of sister chromatid segregation (GO:0033045)3.30688248
82regulation of mitotic spindle organization (GO:0060236)3.29624699
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.26905011
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25953704
85nuclear envelope organization (GO:0006998)3.25353156
86chromatin assembly or disassembly (GO:0006333)3.24887828
87chromosome segregation (GO:0007059)3.24818288
88proteasome assembly (GO:0043248)3.24419619
89negative regulation of histone methylation (GO:0031061)3.23221146
90DNA conformation change (GO:0071103)3.23072499
91regulation of DNA endoreduplication (GO:0032875)3.21494029
92regulation of translational fidelity (GO:0006450)3.19529991
93heterochromatin organization (GO:0070828)3.18974214
94postreplication repair (GO:0006301)3.18348350
95maturation of SSU-rRNA (GO:0030490)3.16100647
96cellular protein complex localization (GO:0034629)3.16093685
97regulation of gene silencing by RNA (GO:0060966)3.15901297
98regulation of posttranscriptional gene silencing (GO:0060147)3.15901297
99regulation of gene silencing by miRNA (GO:0060964)3.15901297
100ATP-dependent chromatin remodeling (GO:0043044)3.15201947
101establishment of integrated proviral latency (GO:0075713)3.15102218
102DNA packaging (GO:0006323)3.13535326
103regulation of helicase activity (GO:0051095)3.12303073
104synapsis (GO:0007129)3.11752036
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10760739
106DNA topological change (GO:0006265)3.08686566
107translesion synthesis (GO:0019985)3.07920771
108L-serine metabolic process (GO:0006563)3.07629661
109dosage compensation (GO:0007549)3.07412017
110DNA synthesis involved in DNA repair (GO:0000731)3.07340914
111negative regulation of RNA splicing (GO:0033119)3.06242919
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05443908
113DNA double-strand break processing (GO:0000729)3.01369932
114ribosome biogenesis (GO:0042254)3.01303779
115negative regulation of mitosis (GO:0045839)3.00244524
116tRNA aminoacylation for protein translation (GO:0006418)3.00196206
117regulation of centrosome duplication (GO:0010824)2.99823656
118negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98509426
119chromosome condensation (GO:0030261)2.97874710
120mitotic cell cycle (GO:0000278)2.96971871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.48755010
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.51702978
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.21547999
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.63359761
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20817557
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98512428
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84182539
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68376242
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66060104
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.61625540
11AR_21909140_ChIP-Seq_LNCAP_Human2.59202228
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56715075
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.52088557
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50329650
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50295751
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.37174390
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30169489
18XRN2_22483619_ChIP-Seq_HELA_Human2.24012396
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.19844204
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19709168
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17037626
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14613961
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.12252039
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08110893
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02406347
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00130463
27E2F7_22180533_ChIP-Seq_HELA_Human10.5551274
28VDR_23849224_ChIP-Seq_CD4+_Human1.91346906
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88177296
30* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87857711
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.82164347
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80356013
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78989609
34FOXP3_21729870_ChIP-Seq_TREG_Human1.78900799
35TTF2_22483619_ChIP-Seq_HELA_Human1.78530025
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75780458
37DCP1A_22483619_ChIP-Seq_HELA_Human1.71769785
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70389951
39ELK1_19687146_ChIP-ChIP_HELA_Human1.69746622
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66062382
41CIITA_25753668_ChIP-Seq_RAJI_Human1.62077391
42MYC_22102868_ChIP-Seq_BL_Human1.61281986
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59905026
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58541946
45* GABP_19822575_ChIP-Seq_HepG2_Human1.57736584
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.53107671
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49086818
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44979529
49KDM5A_27292631_Chip-Seq_BREAST_Human1.42380533
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40528674
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38211451
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38023914
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34881521
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34476675
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34195707
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33602702
57* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31841073
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29967131
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29615195
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25709856
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23932010
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23144198
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20597313
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20493016
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19679615
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19366641
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17522407
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.16958642
69* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15340002
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15199461
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.13066785
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11113701
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07982095
74* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07750369
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07150024
76TFEB_21752829_ChIP-Seq_HELA_Human1.06425412
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.05332980
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03568783
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03541256
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02106278
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01293423
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00965407
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98899073
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98636174
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98636174
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98636174
87* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97532084
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97272921
89TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94318448
90MYC_18940864_ChIP-ChIP_HL60_Human0.92792760
91ZNF263_19887448_ChIP-Seq_K562_Human0.92581450
92* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89589352
93* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89171745
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88442042
95CHD1_26751641_Chip-Seq_LNCaP_Human0.87652408
96SRF_21415370_ChIP-Seq_HL-1_Mouse0.86430763
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.86361429
98* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83630928
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82082323
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81183951
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81151263
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80996863
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80767009
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80510104
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79105534
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.78899659
107TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78049615
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77996706
109* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77772446
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77361491
111EWS_26573619_Chip-Seq_HEK293_Human0.74595127
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74267737
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73677396
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73252634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.81145975
2MP0003693_abnormal_embryo_hatching4.64586025
3MP0003111_abnormal_nucleus_morphology4.37631281
4MP0004957_abnormal_blastocyst_morpholog4.14000522
5MP0008057_abnormal_DNA_replication4.00212530
6MP0003077_abnormal_cell_cycle3.93336104
7MP0003123_paternal_imprinting3.23423610
8MP0008058_abnormal_DNA_repair3.04212440
9MP0008007_abnormal_cellular_replicative2.87753130
10MP0008877_abnormal_DNA_methylation2.75473500
11MP0010352_gastrointestinal_tract_polyps2.63079306
12MP0008932_abnormal_embryonic_tissue2.54587617
13MP0001730_embryonic_growth_arrest2.49835203
14MP0000350_abnormal_cell_proliferation2.39689077
15MP0010030_abnormal_orbit_morphology2.21766013
16MP0003121_genomic_imprinting2.19275237
17MP0010307_abnormal_tumor_latency2.16301394
18MP0005380_embryogenesis_phenotype2.00333238
19MP0001672_abnormal_embryogenesis/_devel2.00333238
20* MP0001697_abnormal_embryo_size1.96116902
21MP0000537_abnormal_urethra_morphology1.93326025
22MP0004197_abnormal_fetal_growth/weight/1.90033373
23MP0003984_embryonic_growth_retardation1.83214532
24MP0002084_abnormal_developmental_patter1.82877393
25* MP0002085_abnormal_embryonic_tissue1.81413650
26MP0002088_abnormal_embryonic_growth/wei1.79678395
27MP0003567_abnormal_fetal_cardiomyocyte1.76269484
28MP0003890_abnormal_embryonic-extraembry1.70169473
29* MP0002080_prenatal_lethality1.68063790
30MP0002396_abnormal_hematopoietic_system1.65046866
31MP0002086_abnormal_extraembryonic_tissu1.63539660
32MP0003786_premature_aging1.61582548
33MP0009053_abnormal_anal_canal1.60534428
34MP0005076_abnormal_cell_differentiation1.58592042
35MP0001293_anophthalmia1.54651994
36MP0002877_abnormal_melanocyte_morpholog1.45846746
37MP0004808_abnormal_hematopoietic_stem1.40922175
38MP0003315_abnormal_perineum_morphology1.38202250
39MP0009672_abnormal_birth_weight1.38135969
40MP0000313_abnormal_cell_death1.32286248
41MP0003119_abnormal_digestive_system1.31299574
42MP0003937_abnormal_limbs/digits/tail_de1.28664467
43MP0002210_abnormal_sex_determination1.25449158
44MP0006035_abnormal_mitochondrial_morpho1.22684560
45MP0009703_decreased_birth_body1.19633870
46MP0000490_abnormal_crypts_of1.17540762
47MP0003806_abnormal_nucleotide_metabolis1.12434641
48MP0001145_abnormal_male_reproductive1.11496664
49MP0002019_abnormal_tumor_incidence1.11248905
50MP0003705_abnormal_hypodermis_morpholog1.11167025
51MP0002653_abnormal_ependyma_morphology1.10815537
52MP0002111_abnormal_tail_morphology1.05153108
53MP0002796_impaired_skin_barrier1.02382065
54MP0000579_abnormal_nail_morphology1.00563277
55MP0002160_abnormal_reproductive_system1.00453726
56MP0006054_spinal_hemorrhage0.99701991
57MP0004133_heterotaxia0.99531242
58MP0002009_preneoplasia0.98412817
59MP0005501_abnormal_skin_physiology0.98273276
60MP0001661_extended_life_span0.97897767
61MP0005623_abnormal_meninges_morphology0.95581396
62MP0000653_abnormal_sex_gland0.94435784
63MP0000428_abnormal_craniofacial_morphol0.94417714
64MP0001929_abnormal_gametogenesis0.94311831
65MP0002092_abnormal_eye_morphology0.93424976
66MP0004185_abnormal_adipocyte_glucose0.93313443
67MP0001346_abnormal_lacrimal_gland0.92333888
68MP0001286_abnormal_eye_development0.92303933
69MP0001915_intracranial_hemorrhage0.91117960
70MP0003122_maternal_imprinting0.88993272
71MP0003115_abnormal_respiratory_system0.88455472
72MP0000647_abnormal_sebaceous_gland0.86961288
73MP0001188_hyperpigmentation0.86624591
74MP0003935_abnormal_craniofacial_develop0.84105340
75MP0000703_abnormal_thymus_morphology0.83212253
76MP0003941_abnormal_skin_development0.83200784
77MP0004233_abnormal_muscle_weight0.83132189
78MP0005367_renal/urinary_system_phenotyp0.83025189
79MP0000516_abnormal_urinary_system0.83025189
80MP0003718_maternal_effect0.81587560
81MP0005187_abnormal_penis_morphology0.81141767
82MP0003787_abnormal_imprinting0.79999403
83MP0001529_abnormal_vocalization0.79554353
84MP0003861_abnormal_nervous_system0.79080897
85MP0000733_abnormal_muscle_development0.79047243
86MP0000432_abnormal_head_morphology0.78566349
87MP0002938_white_spotting0.78008755
88MP0005384_cellular_phenotype0.77855349
89MP0003942_abnormal_urinary_system0.77478163
90MP0003950_abnormal_plasma_membrane0.76779770
91MP0003566_abnormal_cell_adhesion0.75092435
92MP0001299_abnormal_eye_distance/0.74351186
93MP0008789_abnormal_olfactory_epithelium0.74172448
94MP0001119_abnormal_female_reproductive0.73992948
95MP0002697_abnormal_eye_size0.72979488
96MP0003221_abnormal_cardiomyocyte_apopto0.71656003
97MP0002925_abnormal_cardiovascular_devel0.70428056
98MP0005389_reproductive_system_phenotype0.69564355
99MP0003755_abnormal_palate_morphology0.69482862
100MP0005621_abnormal_cell_physiology0.68798927
101MP0000762_abnormal_tongue_morphology0.68721762
102MP0001177_atelectasis0.67546812
103MP0002114_abnormal_axial_skeleton0.66958049
104MP0000358_abnormal_cell_content/0.66153234
105MP0010234_abnormal_vibrissa_follicle0.65811689
106MP0002932_abnormal_joint_morphology0.65642598
107MP0003698_abnormal_male_reproductive0.64654939
108MP0001727_abnormal_embryo_implantation0.64202637
109MP0005023_abnormal_wound_healing0.63069650
110MP0001849_ear_inflammation0.62242026
111MP0003385_abnormal_body_wall0.62038191
112MP0000627_abnormal_mammary_gland0.61859852
113MP0002161_abnormal_fertility/fecundity0.61660395
114MP0002102_abnormal_ear_morphology0.60844719
115MP0000266_abnormal_heart_morphology0.60826781
116MP0002234_abnormal_pharynx_morphology0.60485394
117MP0003943_abnormal_hepatobiliary_system0.60027065
118MP0009697_abnormal_copulation0.59977491
119MP0000049_abnormal_middle_ear0.58066391
120MP0002233_abnormal_nose_morphology0.56826362
121MP0004264_abnormal_extraembryonic_tissu0.54501206
122MP0002075_abnormal_coat/hair_pigmentati0.53530909
123MP0006292_abnormal_olfactory_placode0.52516457
124MP0002081_perinatal_lethality0.52044198

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.03240981
2Medulloblastoma (HP:0002885)3.92020746
3Colon cancer (HP:0003003)3.87963731
4Birth length less than 3rd percentile (HP:0003561)3.83647654
5Chromsome breakage (HP:0040012)3.55263808
6Abnormality of the labia minora (HP:0012880)3.46546060
7Selective tooth agenesis (HP:0001592)3.32540233
8Cortical dysplasia (HP:0002539)3.29635596
9Abnormality of the anterior horn cell (HP:0006802)3.27690224
10Degeneration of anterior horn cells (HP:0002398)3.27690224
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22378125
12Volvulus (HP:0002580)3.14458079
13Increased nuchal translucency (HP:0010880)3.11585171
14Agnosia (HP:0010524)3.08315334
15Abnormality of chromosome stability (HP:0003220)3.03058941
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02471894
17Short 4th metacarpal (HP:0010044)3.02471894
18Rhabdomyosarcoma (HP:0002859)3.00975382
19Abnormality of the astrocytes (HP:0100707)2.90859289
20Astrocytoma (HP:0009592)2.90859289
21Patellar aplasia (HP:0006443)2.90246693
22Proximal placement of thumb (HP:0009623)2.87313582
23Aplasia/Hypoplasia of the patella (HP:0006498)2.85139239
24Deviation of the thumb (HP:0009603)2.84031775
25Abnormal number of incisors (HP:0011064)2.83614150
26Breast hypoplasia (HP:0003187)2.80687163
27Abnormal lung lobation (HP:0002101)2.72151230
28Glioma (HP:0009733)2.71050335
29Meckel diverticulum (HP:0002245)2.70949860
30Impulsivity (HP:0100710)2.67707290
31Abnormality of glycolysis (HP:0004366)2.66817431
32Ectopic kidney (HP:0000086)2.61446242
33Multiple enchondromatosis (HP:0005701)2.59754851
34Reticulocytopenia (HP:0001896)2.55769108
35Abnormality of the ileum (HP:0001549)2.55753663
36Small intestinal stenosis (HP:0012848)2.53066377
37Duodenal stenosis (HP:0100867)2.53066377
38Supernumerary spleens (HP:0009799)2.52766958
39Abnormality of the preputium (HP:0100587)2.51723282
40Absent radius (HP:0003974)2.50135513
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.49673738
42Atresia of the external auditory canal (HP:0000413)2.45238816
43Increased serum pyruvate (HP:0003542)2.42685443
44Oral leukoplakia (HP:0002745)2.39801013
45Basal cell carcinoma (HP:0002671)2.39795281
46Neoplasm of striated muscle (HP:0009728)2.39695376
47Biliary tract neoplasm (HP:0100574)2.38099455
48Neoplasm of the pancreas (HP:0002894)2.37739964
49Nephroblastoma (Wilms tumor) (HP:0002667)2.36271542
50Microvesicular hepatic steatosis (HP:0001414)2.35666050
51Aplasia involving forearm bones (HP:0009822)2.34494541
52Absent forearm bone (HP:0003953)2.34494541
53Myelodysplasia (HP:0002863)2.26769774
54Embryonal renal neoplasm (HP:0011794)2.26714027
55Neoplasm of the oral cavity (HP:0100649)2.25747043
56Sloping forehead (HP:0000340)2.25167816
57Absent thumb (HP:0009777)2.23413641
5811 pairs of ribs (HP:0000878)2.22309617
59Neoplasm of the colon (HP:0100273)2.21746425
60Carpal bone hypoplasia (HP:0001498)2.21653080
61Missing ribs (HP:0000921)2.19077482
62Ovarian neoplasm (HP:0100615)2.16779151
63Choanal atresia (HP:0000453)2.14498908
64Abnormality of the duodenum (HP:0002246)2.14403732
65Pelvic girdle muscle weakness (HP:0003749)2.13951244
66Abnormality of methionine metabolism (HP:0010901)2.13773500
67Cafe-au-lait spot (HP:0000957)2.13509162
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.12922131
69Spastic diplegia (HP:0001264)2.12434603
70Embryonal neoplasm (HP:0002898)2.11704119
71Abnormality of the 4th metacarpal (HP:0010012)2.07921173
72Abnormality of abdominal situs (HP:0011620)2.06693782
73Abdominal situs inversus (HP:0003363)2.06693782
74Renal duplication (HP:0000075)2.04987035
75Facial hemangioma (HP:0000329)2.04926698
76Amaurosis fugax (HP:0100576)2.03136173
77Triphalangeal thumb (HP:0001199)2.02694841
78Microglossia (HP:0000171)2.02366796
79Horseshoe kidney (HP:0000085)2.02309268
80Shoulder girdle muscle weakness (HP:0003547)2.01393745
81Progressive external ophthalmoplegia (HP:0000590)2.01215274
82Atrophy/Degeneration involving motor neurons (HP:0007373)1.99096813
83Abnormality of the carotid arteries (HP:0005344)1.99035515
84Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96547773
85High pitched voice (HP:0001620)1.95586970
86Premature graying of hair (HP:0002216)1.92409845
87Abnormality of the calcaneus (HP:0008364)1.92357654
88Neoplasm of the rectum (HP:0100743)1.92162553
89Abnormality of the umbilical cord (HP:0010881)1.91961834
90Gastrointestinal carcinoma (HP:0002672)1.91042321
91Malignant gastrointestinal tract tumors (HP:0006749)1.91042321
92Intestinal polyp (HP:0005266)1.90637919
93Intestinal polyposis (HP:0200008)1.90288464
94Aplasia/hypoplasia of the humerus (HP:0006507)1.87051400
95High anterior hairline (HP:0009890)1.85790643
96Clubbing of toes (HP:0100760)1.85689763
97Deep philtrum (HP:0002002)1.85350890
98Aplastic anemia (HP:0001915)1.84860585
99Cutaneous melanoma (HP:0012056)1.84588714
100Long eyelashes (HP:0000527)1.84469991
101Single umbilical artery (HP:0001195)1.84336397
102Abnormality of the fetal cardiovascular system (HP:0010948)1.84336397
103Abnormal umbilical cord blood vessels (HP:0011403)1.84336397
104Tracheoesophageal fistula (HP:0002575)1.83652844
105Squamous cell carcinoma (HP:0002860)1.82493931
106Postnatal microcephaly (HP:0005484)1.81589618
107Adenoma sebaceum (HP:0009720)1.81556106
108Angiofibromas (HP:0010615)1.81556106
109Insidious onset (HP:0003587)1.81108241
110Termporal pattern (HP:0011008)1.81108241
111Neoplasm of the small intestine (HP:0100833)1.79854204
112Optic nerve coloboma (HP:0000588)1.78767490
113Rough bone trabeculation (HP:0100670)1.78607642
114Duplication of thumb phalanx (HP:0009942)1.76562566
115Bone marrow hypocellularity (HP:0005528)1.76229376
116Prominent nose (HP:0000448)1.75965088
117Freckling (HP:0001480)1.74506969
118Uterine neoplasm (HP:0010784)1.74412629
119Skull defect (HP:0001362)1.74404697
120Short thumb (HP:0009778)1.71989366
121Facial cleft (HP:0002006)1.71758298
122Abnormality of chromosome segregation (HP:0002916)1.71480772
123Breast carcinoma (HP:0003002)1.70620592
124Trigonocephaly (HP:0000243)1.70250312
125Arteriovenous malformation (HP:0100026)1.68295710
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67424802
127Overlapping toe (HP:0001845)1.66871179
128Secondary amenorrhea (HP:0000869)1.66810663
129Duplicated collecting system (HP:0000081)1.64417252
130Pancreatic islet-cell hyperplasia (HP:0004510)1.64240017
131Leiomyosarcoma (HP:0100243)1.61370824
132Uterine leiomyosarcoma (HP:0002891)1.61370824
133Hypoplastic pelvis (HP:0008839)1.59204272
134Septate vagina (HP:0001153)1.58866032
135Progressive muscle weakness (HP:0003323)1.58264550
136Abnormalities of placenta or umbilical cord (HP:0001194)1.56720217
137Megaloblastic anemia (HP:0001889)1.56683060
138Neoplasm of the adrenal gland (HP:0100631)1.55400303
139Abnormality of cochlea (HP:0000375)1.53608708
140Abnormal auditory evoked potentials (HP:0006958)1.50697774
141Neuroblastoma (HP:0003006)1.50563557
142Primitive neuroectodermal tumor (HP:0030065)1.50563557
143Neuroblastic tumors (HP:0004376)1.50563557
144Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.50563557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.96573945
2WEE14.20924227
3BUB13.88246961
4NEK22.96009423
5NEK12.90582350
6PASK2.87906076
7BRSK22.66078077
8TSSK62.58233089
9SRPK12.56921890
10TTK2.56358204
11EIF2AK12.55465892
12MKNK12.46126855
13CDK122.37363822
14PLK32.23054424
15PLK12.13272143
16PLK42.02048906
17TRIM281.98957000
18ATR1.91117108
19ACVR1B1.83175287
20AURKB1.77603160
21CHEK21.69732749
22MKNK21.68872106
23TAF11.65401110
24TGFBR11.64172637
25VRK21.62893467
26CDK71.61040899
27BRSK11.58328883
28CHEK11.51670095
29CDK41.46245531
30CCNB11.46231698
31SCYL21.44722028
32RPS6KB21.42864147
33VRK11.42701584
34TESK21.38340977
35MAP3K81.33275134
36AURKA1.29291634
37MAP3K101.27952081
38RPS6KA41.27609413
39MST41.25134465
40STK101.23774665
41EIF2AK31.21593655
42EEF2K1.21219259
43SMG11.19360421
44TLK11.19256118
45MST1R1.17549123
46PAK41.17094042
47ATM1.17022185
48PNCK1.16697335
49DYRK31.13566154
50CDK61.12241478
51BRD41.09133230
52STK41.06561843
53CDK21.04583116
54ZAK0.98329882
55ERBB40.96380058
56PKN20.94602423
57ALK0.94016813
58MET0.89563237
59STK30.89026254
60MELK0.89019681
61ERBB30.88019149
62CDK10.87072046
63EPHA20.85809223
64CDK80.80103250
65PDK20.76578869
66FGFR10.73680415
67NUAK10.68842750
68PDK30.66713807
69PDK40.66713807
70CSNK2A20.64987974
71FLT30.64734034
72STK38L0.58384477
73CSNK2A10.57584875
74LATS10.57504510
75EIF2AK20.56672106
76NME10.54759799
77NME20.54291160
78CDK180.53443148
79MTOR0.53043210
80CSNK1G10.51826654
81TESK10.51529682
82WNK30.51353670
83PRKDC0.50948007
84LATS20.50527984
85CDK140.48880438
86CSNK1E0.47960106
87CDK150.47026107
88PAK10.45618478
89CDK11A0.45114547
90TTN0.43256602
91CSNK1D0.42590562
92PIM10.41746189
93PLK20.41184219
94MINK10.41066865
95CLK10.39745885
96MAPK140.39182114
97STK160.38609277
98AKT20.38058803
99NEK90.37691694
100PBK0.37440727
101PRKCI0.37203216
102DAPK10.33769839
103KSR10.33382315
104STK390.33337818
105SIK30.33017227
106YES10.31783914
107LIMK10.30598244
108PAK20.29599732
109CSNK1G20.29455771
110CAMK1G0.29368547
111TNIK0.28091277
112MAP3K90.27817420
113GSK3B0.27102891
114AKT10.26370255
115MARK30.26254264
116CDK90.24959599
117RPS6KB10.24478058
118RPS6KA50.22847549
119BCR0.22172919
120CSNK1A1L0.21907210
121LRRK20.21805203
122CSNK1G30.21801688
123MAPK10.21180240
124BRAF0.20640814
125TAOK20.20351288
126STK240.19890743

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.00405522
2Mismatch repair_Homo sapiens_hsa034304.49962388
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79002577
4RNA transport_Homo sapiens_hsa030133.55360444
5Spliceosome_Homo sapiens_hsa030403.50451424
6Cell cycle_Homo sapiens_hsa041103.34740545
7Base excision repair_Homo sapiens_hsa034103.08251983
8One carbon pool by folate_Homo sapiens_hsa006702.97527500
9Homologous recombination_Homo sapiens_hsa034402.97475299
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91641155
11Nucleotide excision repair_Homo sapiens_hsa034202.85012455
12Non-homologous end-joining_Homo sapiens_hsa034502.51795567
13RNA polymerase_Homo sapiens_hsa030202.45269094
14Proteasome_Homo sapiens_hsa030502.38809044
15Fanconi anemia pathway_Homo sapiens_hsa034602.36952695
16mRNA surveillance pathway_Homo sapiens_hsa030152.27867184
17Pyrimidine metabolism_Homo sapiens_hsa002402.05030951
18RNA degradation_Homo sapiens_hsa030182.04076989
19Basal transcription factors_Homo sapiens_hsa030221.98098156
20Ribosome_Homo sapiens_hsa030101.92917969
21p53 signaling pathway_Homo sapiens_hsa041151.73686125
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54668185
23Systemic lupus erythematosus_Homo sapiens_hsa053221.51700619
24Oocyte meiosis_Homo sapiens_hsa041141.49499271
25Pyruvate metabolism_Homo sapiens_hsa006201.48259423
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42651899
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32147520
28Steroid biosynthesis_Homo sapiens_hsa001001.27909338
29Viral carcinogenesis_Homo sapiens_hsa052031.25588650
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23946835
31Propanoate metabolism_Homo sapiens_hsa006401.22018762
32Epstein-Barr virus infection_Homo sapiens_hsa051691.21401757
33Purine metabolism_Homo sapiens_hsa002301.11317771
34Fatty acid elongation_Homo sapiens_hsa000621.03846905
35MicroRNAs in cancer_Homo sapiens_hsa052061.02437177
36Selenocompound metabolism_Homo sapiens_hsa004501.00591917
37HTLV-I infection_Homo sapiens_hsa051660.96698871
38Herpes simplex infection_Homo sapiens_hsa051680.93845872
39Biosynthesis of amino acids_Homo sapiens_hsa012300.90058579
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89554725
41Basal cell carcinoma_Homo sapiens_hsa052170.87310133
42Antigen processing and presentation_Homo sapiens_hsa046120.86852764
43Hippo signaling pathway_Homo sapiens_hsa043900.85451199
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84321179
45Thyroid cancer_Homo sapiens_hsa052160.83042551
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82546543
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.82287188
48Colorectal cancer_Homo sapiens_hsa052100.79127744
49Small cell lung cancer_Homo sapiens_hsa052220.77804072
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73333097
51TGF-beta signaling pathway_Homo sapiens_hsa043500.73209446
52Alcoholism_Homo sapiens_hsa050340.73144820
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70301150
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67911058
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66066169
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.64028673
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60917006
58Adherens junction_Homo sapiens_hsa045200.60550146
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60215563
60Fatty acid metabolism_Homo sapiens_hsa012120.55762162
61Hedgehog signaling pathway_Homo sapiens_hsa043400.52589526
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51549625
63Legionellosis_Homo sapiens_hsa051340.49847952
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.49627935
65Notch signaling pathway_Homo sapiens_hsa043300.49236487
66Carbon metabolism_Homo sapiens_hsa012000.48757924
67Chronic myeloid leukemia_Homo sapiens_hsa052200.47822242
68Viral myocarditis_Homo sapiens_hsa054160.47815245
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47448047
70Sulfur relay system_Homo sapiens_hsa041220.46376875
71Pentose phosphate pathway_Homo sapiens_hsa000300.43921415
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43164127
73Lysine degradation_Homo sapiens_hsa003100.43078966
74Pathways in cancer_Homo sapiens_hsa052000.41218439
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.40172442
76Hepatitis B_Homo sapiens_hsa051610.40103859
77Arginine and proline metabolism_Homo sapiens_hsa003300.39810186
78Bladder cancer_Homo sapiens_hsa052190.39039307
79Prostate cancer_Homo sapiens_hsa052150.38452936
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38393670
81Wnt signaling pathway_Homo sapiens_hsa043100.37265152
82Metabolic pathways_Homo sapiens_hsa011000.37011350
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36145837
84N-Glycan biosynthesis_Homo sapiens_hsa005100.34796568
85HIF-1 signaling pathway_Homo sapiens_hsa040660.34540942
86Parkinsons disease_Homo sapiens_hsa050120.34228805
87mTOR signaling pathway_Homo sapiens_hsa041500.33734872
88Apoptosis_Homo sapiens_hsa042100.31538855
89Non-small cell lung cancer_Homo sapiens_hsa052230.31484702
90Galactose metabolism_Homo sapiens_hsa000520.31284518
91Endometrial cancer_Homo sapiens_hsa052130.30057966
92Tight junction_Homo sapiens_hsa045300.28295012
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28103027
94Proteoglycans in cancer_Homo sapiens_hsa052050.27543206
95Vitamin B6 metabolism_Homo sapiens_hsa007500.26958696
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26869774
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25218727
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24592429
99Melanoma_Homo sapiens_hsa052180.24584645
100Pancreatic cancer_Homo sapiens_hsa052120.24329921
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23527453
102Fructose and mannose metabolism_Homo sapiens_hsa000510.23477145
103FoxO signaling pathway_Homo sapiens_hsa040680.23390524
104Arginine biosynthesis_Homo sapiens_hsa002200.22995933
105Shigellosis_Homo sapiens_hsa051310.22446341
106Glutathione metabolism_Homo sapiens_hsa004800.18369765
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18009126
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16378538
109beta-Alanine metabolism_Homo sapiens_hsa004100.15878716
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15274879
111Renin-angiotensin system_Homo sapiens_hsa046140.14312433
112Fatty acid biosynthesis_Homo sapiens_hsa000610.13323418
113Measles_Homo sapiens_hsa051620.12135055
114Influenza A_Homo sapiens_hsa051640.11673660
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10621968
116Fatty acid degradation_Homo sapiens_hsa000710.10566902
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10184076
118Folate biosynthesis_Homo sapiens_hsa007900.10055470
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08396460
120Protein export_Homo sapiens_hsa030600.07665864
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.06561149
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.06325400
123Huntingtons disease_Homo sapiens_hsa050160.05424019
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.05001359
125Focal adhesion_Homo sapiens_hsa045100.04602540
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.03260607
127Primary immunodeficiency_Homo sapiens_hsa053400.03011536

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