CSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)6.28813092
2collagen fibril organization (GO:0030199)6.07488427
3cell adhesion mediated by integrin (GO:0033627)5.73612887
4wound healing, spreading of epidermal cells (GO:0035313)5.58748713
5skin morphogenesis (GO:0043589)5.46970930
6endodermal cell differentiation (GO:0035987)5.26895824
7sequestering of extracellular ligand from receptor (GO:0035581)5.06703044
8protein heterotrimerization (GO:0070208)4.93885209
9wound healing, spreading of cells (GO:0044319)4.76770557
10positive regulation of endothelial cell apoptotic process (GO:2000353)4.74339570
11regulation of syncytium formation by plasma membrane fusion (GO:0060142)4.36520764
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.27658895
13negative regulation of fatty acid transport (GO:2000192)4.15748404
14apoptotic cell clearance (GO:0043277)4.14949841
15glycosphingolipid catabolic process (GO:0046479)3.94346966
16regulation of mononuclear cell migration (GO:0071675)3.93942250
17regulation of vitamin D biosynthetic process (GO:0060556)3.93643338
18oligosaccharide catabolic process (GO:0009313)3.91958023
19positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.82541714
20collagen metabolic process (GO:0032963)3.81254028
21positive regulation of macrophage activation (GO:0043032)3.81165308
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.77549836
23collagen catabolic process (GO:0030574)3.76531682
24positive regulation of calcium ion import (GO:0090280)3.70907034
25cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.68803576
26barbed-end actin filament capping (GO:0051016)3.67050724
27plasma membrane repair (GO:0001778)3.65838869
28positive regulation of extracellular matrix organization (GO:1903055)3.65643868
29basement membrane organization (GO:0071711)3.65247213
30positive regulation of monocyte chemotaxis (GO:0090026)3.64131951
31positive regulation of blood vessel endothelial cell migration (GO:0043536)3.61226750
32stress fiber assembly (GO:0043149)3.60848570
33cellular response to vitamin (GO:0071295)3.59592759
34adhesion of symbiont to host (GO:0044406)3.58427134
35multicellular organismal macromolecule metabolic process (GO:0044259)3.53100972
36bone trabecula formation (GO:0060346)3.52272881
37glycolipid catabolic process (GO:0019377)3.51411707
38positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.50215339
39cellular response to thyroid hormone stimulus (GO:0097067)3.49927439
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.49505936
41axon extension involved in axon guidance (GO:0048846)3.49505936
42negative regulation of fibrinolysis (GO:0051918)3.46690581
43extracellular matrix assembly (GO:0085029)3.44679001
44extracellular matrix disassembly (GO:0022617)3.44035519
45multicellular organismal catabolic process (GO:0044243)3.41901671
46cellular response to vitamin D (GO:0071305)3.41416799
47mesenchymal-epithelial cell signaling (GO:0060638)3.41331162
48regulation of macrophage cytokine production (GO:0010935)3.40879399
49positive regulation of osteoblast proliferation (GO:0033690)3.39809485
50cellular response to interferon-alpha (GO:0035457)3.38314095
51epithelial cell-cell adhesion (GO:0090136)3.38279117
52regulation of cholesterol storage (GO:0010885)3.37685723
53dermatan sulfate biosynthetic process (GO:0030208)3.37062584
54negative regulation of smooth muscle cell migration (GO:0014912)3.35384759
55regulation of plasminogen activation (GO:0010755)3.34096082
56vascular endothelial growth factor signaling pathway (GO:0038084)3.33795858
57regulation of vitamin metabolic process (GO:0030656)3.32662843
58eosinophil chemotaxis (GO:0048245)3.31823001
59multicellular organismal metabolic process (GO:0044236)3.31331862
60cell-substrate junction assembly (GO:0007044)3.28796604
61amino sugar catabolic process (GO:0046348)3.22173297
62mesodermal cell differentiation (GO:0048333)3.20454449
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20191297
64substrate-dependent cell migration (GO:0006929)3.19313663
65protein localization to cell surface (GO:0034394)3.18823764
66myeloid dendritic cell differentiation (GO:0043011)3.16571236
67peptidyl-proline hydroxylation (GO:0019511)3.14527054
68retina vasculature morphogenesis in camera-type eye (GO:0061299)3.11332766
69positive regulation of epithelial to mesenchymal transition (GO:0010718)3.11181739
70substrate adhesion-dependent cell spreading (GO:0034446)3.11026723
71adhesion of symbiont to host cell (GO:0044650)3.10053520
72virion attachment to host cell (GO:0019062)3.10053520
73pathway-restricted SMAD protein phosphorylation (GO:0060389)3.09220152
74negative regulation of nitric oxide biosynthetic process (GO:0045019)3.09211148
75decidualization (GO:0046697)3.08130595
76regulation of monocyte chemotaxis (GO:0090025)3.07808177
77glial cell migration (GO:0008347)3.06582182
78regulation of tight junction assembly (GO:2000810)3.05286454
79endothelial cell morphogenesis (GO:0001886)3.04314869
80negative regulation of focal adhesion assembly (GO:0051895)3.04159173
81negative regulation of cell junction assembly (GO:1901889)3.04159173
82negative regulation of adherens junction organization (GO:1903392)3.04159173
83pinocytosis (GO:0006907)3.03800268
84dermatan sulfate metabolic process (GO:0030205)3.02825823
85platelet degranulation (GO:0002576)3.02185590
86ceramide catabolic process (GO:0046514)3.00370291
87positive regulation of hair cycle (GO:0042635)2.99434156
88positive regulation of hair follicle development (GO:0051798)2.99434156
89NIK/NF-kappaB signaling (GO:0038061)2.97734725
90response to peptidoglycan (GO:0032494)2.97181689
91positive regulation of chemokine biosynthetic process (GO:0045080)2.96630448
92extracellular matrix organization (GO:0030198)2.93027417
93adherens junction assembly (GO:0034333)2.92835741
94eosinophil migration (GO:0072677)2.92641272
95extracellular structure organization (GO:0043062)2.91651934
96craniofacial suture morphogenesis (GO:0097094)2.89482500
97wound healing (GO:0042060)2.87928709
98negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.87270115
99cell migration involved in sprouting angiogenesis (GO:0002042)2.85839114
100positive regulation of p38MAPK cascade (GO:1900745)2.84365820
101endocardial cushion development (GO:0003197)2.84214725
102response to thyroid hormone (GO:0097066)2.83132305
103positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.83055842
104regulation of transforming growth factor beta2 production (GO:0032909)2.82295544
105gland morphogenesis (GO:0022612)2.82156402
106negative regulation of anoikis (GO:2000811)2.81772367
107regulation of membrane protein ectodomain proteolysis (GO:0051043)2.80227138
108regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.78100403
109branching involved in salivary gland morphogenesis (GO:0060445)2.77268143
110glomerular basement membrane development (GO:0032836)2.76139627
111cortical actin cytoskeleton organization (GO:0030866)2.75685378
112regulation of integrin-mediated signaling pathway (GO:2001044)2.75424525
113renal filtration (GO:0097205)2.74908053
114extracellular fibril organization (GO:0043206)2.74247118
115keratan sulfate catabolic process (GO:0042340)2.73179030
116protein localization to endosome (GO:0036010)2.72091570
117positive regulation of hemostasis (GO:1900048)2.71889561
118positive regulation of blood coagulation (GO:0030194)2.71889561
119hippo signaling (GO:0035329)2.71285087
120fibril organization (GO:0097435)2.70879288
121response to fluid shear stress (GO:0034405)2.70574883
122cell-substrate adhesion (GO:0031589)2.70428049
123* regulation of monocyte differentiation (GO:0045655)2.69817678
124regulation of podosome assembly (GO:0071801)2.68239746
125cardiac epithelial to mesenchymal transition (GO:0060317)2.67571855
126metanephric mesenchyme development (GO:0072075)2.67128358
127positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.65663486
128regulation of lymphocyte migration (GO:2000401)2.65356424
129positive regulation of tissue remodeling (GO:0034105)2.64458189
130cell-matrix adhesion (GO:0007160)2.64075825
131hyaluronan catabolic process (GO:0030214)2.63034362
132positive regulation of cell adhesion mediated by integrin (GO:0033630)2.62738838
133T-helper 1 type immune response (GO:0042088)2.62616790
134membrane raft organization (GO:0031579)2.62547009
135positive regulation of natural killer cell differentiation (GO:0032825)2.62055593
136negative regulation of interleukin-12 production (GO:0032695)2.59465045
137monocyte chemotaxis (GO:0002548)2.59155097
138tooth mineralization (GO:0034505)2.59090339
139myeloid dendritic cell activation (GO:0001773)2.58790695
140positive regulation of leukocyte chemotaxis (GO:0002690)2.56207985
141membrane lipid catabolic process (GO:0046466)2.55400667
142negative regulation of lipid storage (GO:0010888)2.55133592
143regulation of early endosome to late endosome transport (GO:2000641)2.52148989
144low-density lipoprotein particle clearance (GO:0034383)2.51691745
145regulation of macrophage chemotaxis (GO:0010758)2.51000215
146negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.50967680
147regulation of cellular extravasation (GO:0002691)2.49801683
148positive regulation of lymphocyte migration (GO:2000403)2.49452123
149cellular extravasation (GO:0045123)2.47276484
150cellular response to type I interferon (GO:0071357)2.47169032
151type I interferon signaling pathway (GO:0060337)2.47169032
152positive regulation of cholesterol efflux (GO:0010875)2.45622866
153peptide catabolic process (GO:0043171)2.45371411
154response to type I interferon (GO:0034340)2.44807129
155regulation of chemokine biosynthetic process (GO:0045073)2.43499192
156lymphocyte chemotaxis (GO:0048247)2.43282017
157mannose metabolic process (GO:0006013)2.42764323
158dendritic cell differentiation (GO:0097028)2.40105613
159sphingolipid catabolic process (GO:0030149)2.38728260
160positive regulation of bone remodeling (GO:0046852)2.38615432
161positive regulation of bone resorption (GO:0045780)2.38615432
162cellular response to arsenic-containing substance (GO:0071243)2.37573951
163positive regulation of leukocyte migration (GO:0002687)2.37221950
164response to progesterone (GO:0032570)2.36460704
165regulation of lymphocyte chemotaxis (GO:1901623)2.35796570
166response to laminar fluid shear stress (GO:0034616)2.35779329
167* osteoclast differentiation (GO:0030316)2.33867109
168germinal center formation (GO:0002467)2.33506108
169induction of positive chemotaxis (GO:0050930)2.33165528
170positive regulation of axon extension (GO:0045773)2.30306122
171regulation of extracellular matrix organization (GO:1903053)2.27252722
172cortical cytoskeleton organization (GO:0030865)2.24766667
173regulation of T cell migration (GO:2000404)2.22629309
174macrophage chemotaxis (GO:0048246)2.22289937
175regulation of cytokine secretion involved in immune response (GO:0002739)2.21547133
176iron ion import (GO:0097286)2.21213749
177interferon-gamma-mediated signaling pathway (GO:0060333)2.20386806
178macrophage activation involved in immune response (GO:0002281)2.19863996
179response to magnesium ion (GO:0032026)2.18370494
180negative regulation of biomineral tissue development (GO:0070168)2.17448587
181cell migration involved in heart development (GO:0060973)2.16811142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.21447365
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.77189720
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.80873021
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.84601480
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.39765492
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.19159163
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15407785
8CLOCK_20551151_ChIP-Seq_293T_Human3.00520949
9RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.93264055
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.86315322
11* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.84882264
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.71219665
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.44909565
14CJUN_26792858_Chip-Seq_BT549_Human2.44330744
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44099078
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.43781045
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.42812694
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.42563118
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.34116917
20* IRF8_27001747_Chip-Seq_BMDM_Mouse2.29563058
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.22140703
22* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.22014895
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.21875661
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.15891612
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.10071497
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.10071497
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.09723334
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.05004802
29NRF2_20460467_ChIP-Seq_MEFs_Mouse2.05004802
30BRD4_25478319_ChIP-Seq_HGPS_Human1.97013695
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92434161
32* EP300_21415370_ChIP-Seq_HL-1_Mouse1.90658183
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90043824
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89541917
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89535988
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.88201584
37* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85892791
38VDR_21846776_ChIP-Seq_THP-1_Human1.80343445
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.80083588
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.77811974
41JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77615172
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.76383131
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76310514
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76244472
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.74399607
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.72290576
47VDR_24763502_ChIP-Seq_THP-1_Human1.70450516
48SOX2_20726797_ChIP-Seq_SW620_Human1.66538954
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.62794149
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62420518
51* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62172600
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60680580
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60377989
54* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58130878
55TP53_16413492_ChIP-PET_HCT116_Human1.57587231
56* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57374661
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55353499
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53777557
59ATF3_27146783_Chip-Seq_COLON_Human1.51643183
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49918625
61* UBF1/2_26484160_Chip-Seq_HMECs_Human1.48639949
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48090384
63* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.47565054
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41645484
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38220307
66TP53_22127205_ChIP-Seq_IMR90_Human1.37534993
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36144993
68RACK7_27058665_Chip-Seq_MCF-7_Human1.36130621
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35506748
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33090389
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.32993130
72* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32099420
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31465307
74* TP53_23651856_ChIP-Seq_MEFs_Mouse1.31207728
75* RXR_22158963_ChIP-Seq_LIVER_Mouse1.30828005
76TP53_18474530_ChIP-ChIP_U2OS_Human1.30431265
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26435212
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26034585
79SPI1_23127762_ChIP-Seq_K562_Human1.26030234
80TCF7_22412390_ChIP-Seq_EML_Mouse1.26027494
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24393026
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22319471
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21720961
84* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21488362
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21429736
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.21328643
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.21328643
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.21029616
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20367641
90GATA1_22025678_ChIP-Seq_K562_Human1.19584196
91MAF_26560356_Chip-Seq_TH1_Human1.17218954
92GATA1_19941826_ChIP-Seq_K562_Human1.16435616
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16304067
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15396032
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13711464
96PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12418602
97* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10388090
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09565075
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09004591
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08881424
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08354912
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07690002
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07482274
104MYC_22102868_ChIP-Seq_BL_Human1.05954361
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05016059
106KLF5_25053715_ChIP-Seq_YYC3_Human1.03256730
107ZNF263_19887448_ChIP-Seq_K562_Human1.02469987
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02252844
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.02190863
110* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00860223
111PU_27001747_Chip-Seq_BMDM_Mouse0.99577392
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99393633
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99228505
114LXR_22158963_ChIP-Seq_LIVER_Mouse0.97575610
115* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96912259
116KDM2B_26808549_Chip-Seq_DND41_Human0.96795963
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95854722
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95770522
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94914640
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94680518
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94557880
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92706955
123* LXR_22292898_ChIP-Seq_THP-1_Human0.89871513
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89573131
125NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89517987
126* KDM2B_26808549_Chip-Seq_K562_Human0.89045974
127EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87497110
128RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87497110
129* NFI_21473784_ChIP-Seq_ESCs_Mouse0.87398542
130ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87096044
131VDR_24787735_ChIP-Seq_THP-1_Human0.86786669
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86466299
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86053457
134SA1_22415368_ChIP-Seq_MEFs_Mouse0.85631212
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.85403881
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85209378
137NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84897598
138* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84715670
139* TP63_23658742_ChIP-Seq_EP156T_Human0.84693990
140* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84521917
141ELK1_22589737_ChIP-Seq_MCF10A_Human0.84495122
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83760142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.05434330
2MP0005275_abnormal_skin_tensile4.64487634
3MP0003279_aneurysm4.06284305
4MP0005503_abnormal_tendon_morphology3.99652130
5MP0003705_abnormal_hypodermis_morpholog3.88102552
6MP0009840_abnormal_foam_cell3.69929315
7MP0001958_emphysema3.30798141
8MP0005623_abnormal_meninges_morphology2.95110758
9MP0003566_abnormal_cell_adhesion2.94003833
10MP0006054_spinal_hemorrhage2.86967447
11MP0004272_abnormal_basement_membrane2.71596470
12MP0009278_abnormal_bone_marrow2.65570023
13MP0006082_CNS_inflammation2.60418421
14MP0010352_gastrointestinal_tract_polyps2.54616016
15MP0003191_abnormal_cellular_cholesterol2.47423280
16MP0005023_abnormal_wound_healing2.46481144
17MP0004510_myositis2.40832661
18MP0009384_cardiac_valve_regurgitation2.40633846
19MP0003091_abnormal_cell_migration2.40375531
20MP0002148_abnormal_hypersensitivity_rea2.22315303
21MP0003172_abnormal_lysosome_physiology2.17968564
22MP0003724_increased_susceptibility_to2.08642324
23MP0009785_altered_susceptibility_to2.01460937
24MP0005257_abnormal_intraocular_pressure1.99539165
25MP0002295_abnormal_pulmonary_circulatio1.96978485
26MP0002139_abnormal_hepatobiliary_system1.95338197
27* MP0000604_amyloidosis1.95327957
28* MP0002419_abnormal_innate_immunity1.93092176
29MP0003075_altered_response_to1.91732142
30MP0002060_abnormal_skin_morphology1.91653868
31MP0001545_abnormal_hematopoietic_system1.83141399
32MP0005397_hematopoietic_system_phenotyp1.83141399
33MP0005451_abnormal_body_composition1.81729051
34MP0001853_heart_inflammation1.78847886
35MP0005000_abnormal_immune_tolerance1.78706762
36* MP0005508_abnormal_skeleton_morphology1.76496232
37MP0001542_abnormal_bone_strength1.76345308
38MP0004947_skin_inflammation1.73786062
39MP0001348_abnormal_lacrimal_gland1.69758298
40MP0001835_abnormal_antigen_presentation1.69458159
41MP0005387_immune_system_phenotype1.69059378
42MP0001790_abnormal_immune_system1.69059378
43MP0005671_abnormal_response_to1.62090145
44MP0001243_abnormal_dermal_layer1.60409842
45MP0000733_abnormal_muscle_development1.59021491
46MP0000013_abnormal_adipose_tissue1.57703644
47MP0000767_abnormal_smooth_muscle1.57580288
48MP0005025_abnormal_response_to1.56514292
49MP0008004_abnormal_stomach_pH1.56396960
50MP0009250_abnormal_appendicular_skeleto1.54092028
51MP0009764_decreased_sensitivity_to1.49029638
52MP0002896_abnormal_bone_mineralization1.42785325
53MP0001299_abnormal_eye_distance/1.42502067
54MP0003385_abnormal_body_wall1.41345862
55MP0003045_fibrosis1.40918145
56MP0003300_gastrointestinal_ulcer1.39881953
57MP0000685_abnormal_immune_system1.39831934
58* MP0002452_abnormal_antigen_presenting1.39330326
59MP0010030_abnormal_orbit_morphology1.38387719
60MP0010368_abnormal_lymphatic_system1.34430239
61MP0000750_abnormal_muscle_regeneration1.33997066
62MP0001533_abnormal_skeleton_physiology1.33517381
63MP0004858_abnormal_nervous_system1.32709300
64MP0002877_abnormal_melanocyte_morpholog1.32602391
65MP0002933_joint_inflammation1.31943028
66* MP0005390_skeleton_phenotype1.28077210
67MP0003656_abnormal_erythrocyte_physiolo1.28072790
68MP0002723_abnormal_immune_serum1.25352066
69MP0003690_abnormal_glial_cell1.22198522
70* MP0001845_abnormal_inflammatory_respons1.20271678
71MP0003303_peritoneal_inflammation1.19855758
72MP0005166_decreased_susceptibility_to1.19777663
73MP0002108_abnormal_muscle_morphology1.16524921
74MP0005464_abnormal_platelet_physiology1.16177716
75* MP0003329_amyloid_beta_deposits1.15142403
76MP0005164_abnormal_response_to1.14365500
77MP0002168_other_aberrant_phenotype1.14026778
78MP0008469_abnormal_protein_level1.13401275
79MP0003448_altered_tumor_morphology1.11784670
80MP0001849_ear_inflammation1.08863390
81* MP0002405_respiratory_system_inflammati1.07853447
82MP0000858_altered_metastatic_potential1.06770090
83MP0001800_abnormal_humoral_immune1.06413064
84* MP0002420_abnormal_adaptive_immunity1.04337001
85MP0002115_abnormal_skeleton_extremities1.02605432
86* MP0001819_abnormal_immune_cell1.02425379
87MP0000163_abnormal_cartilage_morphology1.01892678
88* MP0002998_abnormal_bone_remodeling1.00707861
89MP0002254_reproductive_system_inflammat0.99592487
90* MP0009333_abnormal_splenocyte_physiolog0.99219490
91MP0003950_abnormal_plasma_membrane0.99210370
92MP0002282_abnormal_trachea_morphology0.97966021
93MP0005595_abnormal_vascular_smooth0.96006122
94MP0002128_abnormal_blood_circulation0.95932349
95* MP0000920_abnormal_myelination0.94894260
96MP0000343_altered_response_to0.94741211
97MP0005076_abnormal_cell_differentiation0.94380519
98* MP0001614_abnormal_blood_vessel0.93264976
99MP0009053_abnormal_anal_canal0.93183796
100MP0000003_abnormal_adipose_tissue0.91592927
101MP0001915_intracranial_hemorrhage0.91372459
102MP0001879_abnormal_lymphatic_vessel0.91116876
103MP0003115_abnormal_respiratory_system0.90166944
104MP0010155_abnormal_intestine_physiology0.89875644
105* MP0002113_abnormal_skeleton_development0.89154948
106MP0003453_abnormal_keratinocyte_physiol0.87025429
107MP0000751_myopathy0.86659214
108MP0005197_abnormal_uvea_morphology0.84103193
109MP0009763_increased_sensitivity_to0.83942661
110MP0003755_abnormal_palate_morphology0.83056887
111MP0000428_abnormal_craniofacial_morphol0.82175225
112MP0004084_abnormal_cardiac_muscle0.81055381
113* MP0003795_abnormal_bone_structure0.80149851
114MP0001851_eye_inflammation0.79670635
115MP0004134_abnormal_chest_morphology0.78782697
116MP0002932_abnormal_joint_morphology0.78429052
117MP0004883_abnormal_blood_vessel0.78382272
118MP0005388_respiratory_system_phenotype0.77609261
119MP0002133_abnormal_respiratory_system0.77609261
120MP0003436_decreased_susceptibility_to0.77297963
121MP0002925_abnormal_cardiovascular_devel0.77018027
122MP0003942_abnormal_urinary_system0.76476193
123MP0004087_abnormal_muscle_fiber0.76016982
124MP0008260_abnormal_autophagy0.75304586
125MP0000534_abnormal_ureter_morphology0.73335396
126MP0003283_abnormal_digestive_organ0.72085743
127MP0000716_abnormal_immune_system0.72005913
128MP0003941_abnormal_skin_development0.71772152
129* MP0003634_abnormal_glial_cell0.69903828
130MP0001177_atelectasis0.68298285
131MP0005058_abnormal_lysosome_morphology0.67744850
132MP0005193_abnormal_anterior_eye0.67213603
133MP0005167_abnormal_blood-brain_barrier0.67107284
134MP0005375_adipose_tissue_phenotype0.66941200
135* MP0000249_abnormal_blood_vessel0.66934717
136* MP0001175_abnormal_lung_morphology0.65916220
137MP0000749_muscle_degeneration0.65868532
138MP0004233_abnormal_muscle_weight0.64407036
139MP0002332_abnormal_exercise_endurance0.63975089
140MP0002928_abnormal_bile_duct0.63644770
141MP0005165_increased_susceptibility_to0.63211103
142MP0010630_abnormal_cardiac_muscle0.61948813
143* MP0000759_abnormal_skeletal_muscle0.61302844
144MP0004185_abnormal_adipocyte_glucose0.59350376
145MP0002089_abnormal_postnatal_growth/wei0.58801762
146MP0010771_integument_phenotype0.58654723
147MP0003935_abnormal_craniofacial_develop0.57047256
148MP0005330_cardiomyopathy0.56951771
149* MP0000432_abnormal_head_morphology0.56622027
150MP0000467_abnormal_esophagus_morphology0.56240101
151MP0003828_pulmonary_edema0.55299733
152MP0002109_abnormal_limb_morphology0.55053854

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.69406259
2Protrusio acetabuli (HP:0003179)7.97066786
3Abnormality of glycolipid metabolism (HP:0010969)6.39866673
4Abnormality of liposaccharide metabolism (HP:0010968)6.39866673
5Abnormality of glycosphingolipid metabolism (HP:0004343)6.39866673
6Aortic dissection (HP:0002647)6.16320546
7Peritonitis (HP:0002586)5.28426940
8Aortic aneurysm (HP:0004942)4.54611452
9Shallow orbits (HP:0000586)4.53220448
10Atrophic scars (HP:0001075)4.51753097
11Cerebral aneurysm (HP:0004944)4.45909275
12Soft skin (HP:0000977)4.38988502
13Vascular tortuosity (HP:0004948)4.22744331
14Arterial tortuosity (HP:0005116)4.15987667
15Ankle contracture (HP:0006466)4.09757368
16Fragile skin (HP:0001030)4.06835294
17Dysostosis multiplex (HP:0000943)3.98537995
18Dilatation of the ascending aorta (HP:0005111)3.94920485
19Vertebral compression fractures (HP:0002953)3.75043560
20Spondylolisthesis (HP:0003302)3.71916447
21Systemic lupus erythematosus (HP:0002725)3.71533954
22Cervical subluxation (HP:0003308)3.68438032
23Abnormality of dentin (HP:0010299)3.60336645
24Mitral valve prolapse (HP:0001634)3.59066745
25Vacuolated lymphocytes (HP:0001922)3.50680611
26Wormian bones (HP:0002645)3.47246156
27Bladder diverticulum (HP:0000015)3.45752774
28Myocardial infarction (HP:0001658)3.43332273
29Increased cerebral lipofuscin (HP:0011813)3.40812413
30Neurofibrillary tangles (HP:0002185)3.37255484
31Genu recurvatum (HP:0002816)3.36056416
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.31132330
33Abnormality of polysaccharide metabolism (HP:0011012)3.31132330
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.31132330
35Blue sclerae (HP:0000592)3.29264540
36Broad metatarsal (HP:0001783)3.28787792
37Abnormality of macrophages (HP:0004311)3.24333039
38Urinary glycosaminoglycan excretion (HP:0003541)3.19332990
39Mucopolysacchariduria (HP:0008155)3.19332990
40Loss of speech (HP:0002371)3.18205228
41Spinal rigidity (HP:0003306)3.13469541
42Biconcave vertebral bodies (HP:0004586)3.08350507
43Increased connective tissue (HP:0009025)3.04426509
44Wrist flexion contracture (HP:0001239)3.03135244
45Axonal loss (HP:0003447)2.93051242
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.87638583
47Osteolytic defects of the hand bones (HP:0009699)2.87638583
48Nuclear cataract (HP:0100018)2.83623768
49Type 1 muscle fiber predominance (HP:0003803)2.83024228
50Abnormal delivery (HP:0001787)2.78732289
51Neonatal short-limb short stature (HP:0008921)2.78497958
52Short nail (HP:0001799)2.71740580
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.70734833
54Ulnar bowing (HP:0003031)2.69754825
55Hyperextensible skin (HP:0000974)2.66115354
56Infantile muscular hypotonia (HP:0008947)2.62921026
57Abnormality of the acetabulum (HP:0003170)2.61540191
58Cerebral inclusion bodies (HP:0100314)2.60268427
59Aneurysm (HP:0002617)2.59897913
60Abnormality of complement system (HP:0005339)2.56665366
61Radial bowing (HP:0002986)2.54435870
62Elbow flexion contracture (HP:0002987)2.52405125
63Asymmetric septal hypertrophy (HP:0001670)2.51555917
64Follicular hyperkeratosis (HP:0007502)2.50946386
65Complement deficiency (HP:0004431)2.46533829
66Tibial bowing (HP:0002982)2.40394697
67Distal upper limb amyotrophy (HP:0007149)2.39458828
68Upper limb amyotrophy (HP:0009129)2.39458828
69Increased density of long bones (HP:0006392)2.37201546
70Interstitial pulmonary disease (HP:0006530)2.35407045
71Abnormality of the peritoneum (HP:0002585)2.35005112
72Bowel diverticulosis (HP:0005222)2.34495010
73Scapular winging (HP:0003691)2.34310365
74Thin bony cortex (HP:0002753)2.34024957
75Camptodactyly of toe (HP:0001836)2.33244115
76Bowing of the arm (HP:0006488)2.30138909
77Bowed forearm bones (HP:0003956)2.30138909
78Increased variability in muscle fiber diameter (HP:0003557)2.27395574
79Round ear (HP:0100830)2.26016544
80Overgrowth (HP:0001548)2.25725866
81Distal lower limb amyotrophy (HP:0008944)2.24423992
82Increased serum ferritin (HP:0003281)2.21153114
83Xanthomatosis (HP:0000991)2.20340714
84Ectopia lentis (HP:0001083)2.18526410
85Wide anterior fontanel (HP:0000260)2.15522772
86Hepatosplenomegaly (HP:0001433)2.14010305
87Difficulty climbing stairs (HP:0003551)2.13681931
88Mildly elevated creatine phosphokinase (HP:0008180)2.13166928
89Femoral bowing (HP:0002980)2.12586919
90Abnormality of the calcaneus (HP:0008364)2.11636911
91Coxa vara (HP:0002812)2.11105840
92Protuberant abdomen (HP:0001538)2.11099599
93Apathy (HP:0000741)2.09691258
94Joint laxity (HP:0001388)2.09251629
95Broad face (HP:0000283)2.04193945
96Eczematoid dermatitis (HP:0000976)2.03903562
97Skin nodule (HP:0200036)2.03723680
98Supranuclear gaze palsy (HP:0000605)2.03367784
99Buphthalmos (HP:0000557)2.02945389
100Diminished motivation (HP:0000745)2.02128167
101Ovoid vertebral bodies (HP:0003300)2.01837553
102Mitral regurgitation (HP:0001653)2.01418170
103Deviation of the hallux (HP:0010051)1.99832573
104Amyloidosis (HP:0011034)1.98743284
105Progressive neurologic deterioration (HP:0002344)1.98062230
106Abnormality of skeletal muscle fiber size (HP:0012084)1.97025792
107Hallux valgus (HP:0001822)1.96916016
108Persistence of primary teeth (HP:0006335)1.96637383
109Purpura (HP:0000979)1.96398105
110Tarsal synostosis (HP:0008368)1.96231692
111Disinhibition (HP:0000734)1.95587898
112Muscle fiber splitting (HP:0003555)1.95113660
113Joint stiffness (HP:0001387)1.94449103
114Nonimmune hydrops fetalis (HP:0001790)1.94198158
115Coronal craniosynostosis (HP:0004440)1.94097396
116Slender build (HP:0001533)1.92974172
117Venous abnormality (HP:0002624)1.92738440
118Polycythemia (HP:0001901)1.92523127
119Achilles tendon contracture (HP:0001771)1.92383907
120Absent frontal sinuses (HP:0002688)1.91267447
121Emphysema (HP:0002097)1.90603636
122Segmental peripheral demyelination/remyelination (HP:0003481)1.90536714
123Congenital glaucoma (HP:0001087)1.89428394
124Fused cervical vertebrae (HP:0002949)1.88938292
125Mesomelia (HP:0003027)1.88797983
126J-shaped sella turcica (HP:0002680)1.87254312
127Abnormality of the costochondral junction (HP:0000919)1.87048049
128Distal lower limb muscle weakness (HP:0009053)1.86086110
129Upper motor neuron abnormality (HP:0002127)1.84834694
130Hyporeflexia of lower limbs (HP:0002600)1.84676351
131Flexion contracture of toe (HP:0005830)1.84480481
132Joint contractures involving the joints of the feet (HP:0100492)1.84480481
133Bone pain (HP:0002653)1.84339157
134Pathologic fracture (HP:0002756)1.82637209
135Beaking of vertebral bodies (HP:0004568)1.82150694
136Hyperacusis (HP:0010780)1.81885844
137Long toe (HP:0010511)1.81305972
138Pulmonary artery stenosis (HP:0004415)1.80300932
139Recurrent abscess formation (HP:0002722)1.80087429
140Aortic regurgitation (HP:0001659)1.79634016
141Syringomyelia (HP:0003396)1.79387929
142Spinal cord lesions (HP:0100561)1.79387929
143Mediastinal lymphadenopathy (HP:0100721)1.78964034
144Thin skin (HP:0000963)1.76748836
145Increased mean platelet volume (HP:0011877)1.76736963
146Knee flexion contracture (HP:0006380)1.76411515
147Broad ribs (HP:0000885)1.76338920
148Premature loss of primary teeth (HP:0006323)1.76027671
149Right ventricular cardiomyopathy (HP:0011663)1.75924482
150Delayed closure of the anterior fontanelle (HP:0001476)1.75790178
151Autoimmune thrombocytopenia (HP:0001973)1.75279085
152Prolonged neonatal jaundice (HP:0006579)1.74207585
153Generalized amyotrophy (HP:0003700)1.72390967
154Osteoarthritis (HP:0002758)1.72099482
155Lower limb amyotrophy (HP:0007210)1.71893227
156Recurrent bacterial skin infections (HP:0005406)1.71132958
157Breech presentation (HP:0001623)1.71083487
158Mutism (HP:0002300)1.70829438
159Mitral stenosis (HP:0001718)1.70805322
160Glomerulonephritis (HP:0000099)1.70786676
161Orchitis (HP:0100796)1.69082175
162Cardiomegaly (HP:0001640)1.66290692
163Pulmonary infiltrates (HP:0002113)1.65771165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.27246087
2IRAK34.76276901
3DDR23.65044200
4TRIB33.61313668
5PDGFRA2.92327330
6ERN12.92090096
7LATS22.60973838
8EPHA22.48162019
9TAOK22.47816471
10PRPF4B2.41917478
11PAK22.41026491
12GRK72.38275325
13LATS12.25649046
14PTK22.13186535
15PKN22.09557449
16DMPK2.02997884
17BMX2.02689272
18TESK12.00096544
19EPHB11.99062045
20MYLK1.98630190
21TRPM71.96647212
22LIMK11.93464545
23PAK31.87857743
24TGFBR21.78389602
25FER1.72792850
26TYK21.71203034
27MOS1.69457498
28PIM21.67799509
29PAK41.58674366
30EPHB21.57682193
31PIK3CG1.57021654
32LRRK21.56719597
33PTK2B1.56612641
34MET1.55218573
35RIPK11.43452050
36PTK61.41615069
37MAP3K131.31600313
38MATK1.28037106
39SIK11.26555189
40ARAF1.24335318
41BLK1.23792391
42TESK21.23334287
43RPS6KA41.20458692
44EPHA31.20099347
45PIK3CA1.18752709
46ZAP701.17180358
47NEK91.14279348
48PDGFRB1.13716088
49ROCK11.07461578
50DAPK31.06782389
51NTRK11.04655143
52STK31.03152780
53ILK1.01135453
54MAP3K10.99713389
55MAP4K10.98287932
56SMG10.98186626
57ROCK20.96722265
58STK100.96362142
59TBK10.95564633
60ICK0.91958381
61MAPK70.91421638
62MTOR0.89070880
63MAPKAPK30.87318375
64RIPK40.83051682
65ABL20.82581296
66PAK10.82080905
67IKBKE0.80014326
68FGFR10.78872532
69PRKD10.77613658
70MAP2K10.77124499
71MAPK40.75128275
72INSR0.74792236
73MAP3K30.73751695
74RPS6KA20.70323044
75MAPKAPK50.68992573
76JAK10.68338678
77ERBB40.67631775
78JAK30.67589262
79CSK0.62837997
80CHUK0.62430867
81CDC42BPA0.62070228
82RET0.61920597
83IRAK40.61867053
84MAP3K80.58746538
85PDPK10.55966914
86PRKG20.55942021
87PAK60.55831004
88RPS6KL10.55783292
89RPS6KC10.55783292
90MAP3K100.55749923
91CLK10.55410516
92TAOK10.52433813
93HCK0.50561424
94SRC0.50267658
95PRKD20.49347711
96ADRBK20.49091526
97JAK20.48779766
98MST1R0.48348280
99MAPK120.48283299
100KDR0.47778144
101HIPK20.47293280
102SIK30.46627315
103MAP3K60.46522176
104TYRO30.45700817
105MAPKAPK20.45639582
106CAMK2G0.45417563
107ABL10.43683047
108NME20.43630170
109EEF2K0.43253289
110MAP3K50.41798440
111CDK140.41571208
112DYRK1B0.41539128
113CDK60.41380280
114KIT0.41330541
115CSF1R0.41173438
116PRKCH0.40990881
117FGFR40.39919901
118TXK0.39479200
119ERBB30.38761192
120MAP3K140.38601251
121RPS6KA60.37737601
122EGFR0.37289037
123KSR20.35297139
124CDK150.35280143
125MAP2K30.34457224
126MAPK110.33619098
127GSK3A0.32839607
128FYN0.32234303
129IRAK20.32102422
130FGFR20.31414838
131PKN10.31232709
132GRK50.30400431
133ALK0.29200065
134FGR0.28204228
135CDK180.27855229
136CDK11A0.27824008
137CAMK2D0.27695370
138PRKD30.27547211
139IKBKB0.26580631
140MAP3K110.25327013
141FLT30.23868350
142WNK10.22607268

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.87582788
2Focal adhesion_Homo sapiens_hsa045102.98511075
3Malaria_Homo sapiens_hsa051442.83359019
4AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.42412969
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.41919494
6Amoebiasis_Homo sapiens_hsa051462.39340141
7Proteoglycans in cancer_Homo sapiens_hsa052052.38847241
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.30247039
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.24753796
10Bladder cancer_Homo sapiens_hsa052192.22077871
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.21347216
12Dilated cardiomyopathy_Homo sapiens_hsa054142.09356342
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.00150696
14TGF-beta signaling pathway_Homo sapiens_hsa043501.89764906
15Small cell lung cancer_Homo sapiens_hsa052221.82585257
16Allograft rejection_Homo sapiens_hsa053301.81125471
17Adherens junction_Homo sapiens_hsa045201.80280530
18Shigellosis_Homo sapiens_hsa051311.79277044
19MicroRNAs in cancer_Homo sapiens_hsa052061.78290046
20Chronic myeloid leukemia_Homo sapiens_hsa052201.73185929
21Leishmaniasis_Homo sapiens_hsa051401.65815632
22Regulation of actin cytoskeleton_Homo sapiens_hsa048101.65550744
23Graft-versus-host disease_Homo sapiens_hsa053321.56414498
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.55561668
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.51753021
26Hippo signaling pathway_Homo sapiens_hsa043901.48960578
27Asthma_Homo sapiens_hsa053101.48691706
28Phagosome_Homo sapiens_hsa041451.44438542
29Protein digestion and absorption_Homo sapiens_hsa049741.40310245
30* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.38508255
31Autoimmune thyroid disease_Homo sapiens_hsa053201.37217012
32Pancreatic cancer_Homo sapiens_hsa052121.37098631
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36373495
34Salmonella infection_Homo sapiens_hsa051321.34514520
35Viral myocarditis_Homo sapiens_hsa054161.33685916
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.32408095
37Toxoplasmosis_Homo sapiens_hsa051451.30670452
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28115536
39* TNF signaling pathway_Homo sapiens_hsa046681.28081040
40p53 signaling pathway_Homo sapiens_hsa041151.27115439
41Pertussis_Homo sapiens_hsa051331.23761975
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.22335273
43Antigen processing and presentation_Homo sapiens_hsa046121.21191578
44Influenza A_Homo sapiens_hsa051641.21043710
45Renal cell carcinoma_Homo sapiens_hsa052111.17642877
46Melanoma_Homo sapiens_hsa052181.16101411
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16094054
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14868004
49Lysosome_Homo sapiens_hsa041421.12894066
50African trypanosomiasis_Homo sapiens_hsa051431.10974685
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09151461
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04416856
53Platelet activation_Homo sapiens_hsa046111.04391471
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03866450
55Type I diabetes mellitus_Homo sapiens_hsa049401.03710645
56Tight junction_Homo sapiens_hsa045301.02921288
57Tuberculosis_Homo sapiens_hsa051521.02897687
58Apoptosis_Homo sapiens_hsa042101.02365870
59* Osteoclast differentiation_Homo sapiens_hsa043801.01160095
60Hepatitis C_Homo sapiens_hsa051601.00109874
61Galactose metabolism_Homo sapiens_hsa000520.98306504
62Glioma_Homo sapiens_hsa052140.98137233
63Chemokine signaling pathway_Homo sapiens_hsa040620.96157773
64* Rap1 signaling pathway_Homo sapiens_hsa040150.92697818
65* Rheumatoid arthritis_Homo sapiens_hsa053230.92606018
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90136682
67B cell receptor signaling pathway_Homo sapiens_hsa046620.86157594
68Pentose phosphate pathway_Homo sapiens_hsa000300.85760884
69Axon guidance_Homo sapiens_hsa043600.85592647
70Prostate cancer_Homo sapiens_hsa052150.85420301
71PPAR signaling pathway_Homo sapiens_hsa033200.84690485
72Pathways in cancer_Homo sapiens_hsa052000.83981275
73Fructose and mannose metabolism_Homo sapiens_hsa000510.83743860
74Hepatitis B_Homo sapiens_hsa051610.83045969
75Herpes simplex infection_Homo sapiens_hsa051680.82783936
76Complement and coagulation cascades_Homo sapiens_hsa046100.80911562
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80228921
78Endocytosis_Homo sapiens_hsa041440.79573684
79Acute myeloid leukemia_Homo sapiens_hsa052210.78137819
80HIF-1 signaling pathway_Homo sapiens_hsa040660.75934395
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75819569
82VEGF signaling pathway_Homo sapiens_hsa043700.75483909
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.75225473
84HTLV-I infection_Homo sapiens_hsa051660.74391582
85* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73019372
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.69742279
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68558645
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68360369
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.67879497
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66486116
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65485087
92Colorectal cancer_Homo sapiens_hsa052100.65356443
93Sulfur metabolism_Homo sapiens_hsa009200.64932323
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.64748863
95Notch signaling pathway_Homo sapiens_hsa043300.64696879
96Collecting duct acid secretion_Homo sapiens_hsa049660.63163534
97Other glycan degradation_Homo sapiens_hsa005110.63021633
98MAPK signaling pathway_Homo sapiens_hsa040100.59147366
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58500682
100* Ras signaling pathway_Homo sapiens_hsa040140.58150838
101FoxO signaling pathway_Homo sapiens_hsa040680.58108519
102Viral carcinogenesis_Homo sapiens_hsa052030.57384867
103Legionellosis_Homo sapiens_hsa051340.56423488
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55771071
105Prolactin signaling pathway_Homo sapiens_hsa049170.52959695
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.52603514
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52429062
108Renin-angiotensin system_Homo sapiens_hsa046140.51839913
109Basal cell carcinoma_Homo sapiens_hsa052170.51736295
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.51166859
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.51016097
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50640375
113Prion diseases_Homo sapiens_hsa050200.50453355
114ErbB signaling pathway_Homo sapiens_hsa040120.50213132
115Gap junction_Homo sapiens_hsa045400.49470338
116T cell receptor signaling pathway_Homo sapiens_hsa046600.48175471
117Estrogen signaling pathway_Homo sapiens_hsa049150.47919549
118Staphylococcus aureus infection_Homo sapiens_hsa051500.47559859
119GnRH signaling pathway_Homo sapiens_hsa049120.47260014
120Mineral absorption_Homo sapiens_hsa049780.44203580
121Thyroid hormone synthesis_Homo sapiens_hsa049180.42644285
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42467512
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.42431430
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.41452699
125* Hematopoietic cell lineage_Homo sapiens_hsa046400.40980559
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40863948
127Hedgehog signaling pathway_Homo sapiens_hsa043400.40851491
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39649295
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38759772
130Wnt signaling pathway_Homo sapiens_hsa043100.38666447
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38240259
132Vibrio cholerae infection_Homo sapiens_hsa051100.37726936
133Glutathione metabolism_Homo sapiens_hsa004800.36589136
134Caffeine metabolism_Homo sapiens_hsa002320.35941985
135Measles_Homo sapiens_hsa051620.35042576
136Sphingolipid metabolism_Homo sapiens_hsa006000.32904109
137Insulin resistance_Homo sapiens_hsa049310.30660569

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