CSF1R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)9.75212289
2regulation of interferon-beta biosynthetic process (GO:0045357)7.80136031
3positive regulation by symbiont of host defense response (GO:0052509)7.73170878
4modulation by symbiont of host defense response (GO:0052031)7.73170878
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.73170878
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.73170878
7positive regulation by organism of defense response of other organism involved in symbiotic interact7.73170878
8modulation by symbiont of host immune response (GO:0052553)7.73170878
9macrophage activation involved in immune response (GO:0002281)7.41230846
10G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.22215341
11negative regulation of granulocyte differentiation (GO:0030853)6.12179527
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.11217071
13macrophage activation (GO:0042116)5.68601653
14keratan sulfate catabolic process (GO:0042340)5.14224866
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.07080061
16positive regulation of interferon-alpha production (GO:0032727)4.99798585
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.71511120
18response to host immune response (GO:0052572)4.71511120
19regulation of interferon-alpha production (GO:0032647)4.68435045
20positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.66502709
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.60401769
22response to host (GO:0075136)4.60401769
23response to host defenses (GO:0052200)4.60401769
24I-kappaB phosphorylation (GO:0007252)4.51570919
25glycosphingolipid catabolic process (GO:0046479)4.50097232
26oligosaccharide catabolic process (GO:0009313)4.48011283
27G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.40992458
28mannose metabolic process (GO:0006013)4.38250292
29regulation of B cell receptor signaling pathway (GO:0050855)4.35743164
30hyaluronan catabolic process (GO:0030214)4.28955790
31purinergic nucleotide receptor signaling pathway (GO:0035590)4.27439108
32positive regulation of B cell differentiation (GO:0045579)4.15378088
33positive regulation of mast cell activation involved in immune response (GO:0033008)4.10954711
34positive regulation of mast cell degranulation (GO:0043306)4.10954711
35positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.09725126
36positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.09112166
37positive regulation of mast cell activation (GO:0033005)4.06979097
38detection of molecule of bacterial origin (GO:0032490)4.03899909
39glycolipid catabolic process (GO:0019377)4.01664621
40myeloid cell activation involved in immune response (GO:0002275)3.97681931
41positive regulation of antigen processing and presentation (GO:0002579)3.97303172
42chondroitin sulfate catabolic process (GO:0030207)3.95203899
43regulation of myeloid leukocyte mediated immunity (GO:0002886)3.94243361
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92519230
45negative regulation of cell killing (GO:0031342)3.92519230
46detection of other organism (GO:0098543)3.86062492
47negative regulation of interleukin-6 production (GO:0032715)3.76121795
48cellular extravasation (GO:0045123)3.69858490
49pathway-restricted SMAD protein phosphorylation (GO:0060389)3.69667925
50regulation of leukocyte degranulation (GO:0043300)3.68549591
51detection of external biotic stimulus (GO:0098581)3.65641981
52germ cell migration (GO:0008354)3.61683466
53regulation of mononuclear cell migration (GO:0071675)3.57515543
54purinergic receptor signaling pathway (GO:0035587)3.56998842
55ceramide catabolic process (GO:0046514)3.56435532
56detection of bacterium (GO:0016045)3.55722699
57positive regulation of leukocyte degranulation (GO:0043302)3.55583478
58cellular response to thyroid hormone stimulus (GO:0097067)3.52757715
59negative regulation of bone resorption (GO:0045779)3.52076809
60immunoglobulin mediated immune response (GO:0016064)3.51990382
61regulation of gamma-delta T cell activation (GO:0046643)3.51569904
62regulation of mast cell activation (GO:0033003)3.50552921
63response to muramyl dipeptide (GO:0032495)3.49183110
64T-helper 1 type immune response (GO:0042088)3.42828734
65regulation of hypersensitivity (GO:0002883)3.42683375
66respiratory burst (GO:0045730)3.38957195
67regulation of monocyte differentiation (GO:0045655)3.38855189
68negative regulation of tissue remodeling (GO:0034104)3.37910192
69response to cholesterol (GO:0070723)3.37451289
70amino sugar catabolic process (GO:0046348)3.36534277
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.35182191
72B cell mediated immunity (GO:0019724)3.33986430
73response to peptidoglycan (GO:0032494)3.33471479
74lysosome organization (GO:0007040)3.31892633
75lytic vacuole organization (GO:0080171)3.31892633
76interferon-gamma-mediated signaling pathway (GO:0060333)3.27088966
77detection of biotic stimulus (GO:0009595)3.26734023
78positive regulation of interferon-beta production (GO:0032728)3.26298929
79neutrophil activation involved in immune response (GO:0002283)3.25110382
80neutrophil activation (GO:0042119)3.24801657
81regulation of antigen processing and presentation (GO:0002577)3.19352886
82apoptotic cell clearance (GO:0043277)3.19143322
83adaptation of signaling pathway (GO:0023058)3.17996354
84N-acetylneuraminate metabolic process (GO:0006054)3.17823462
85regulation of macrophage chemotaxis (GO:0010758)3.15017806
86regulation of interferon-gamma biosynthetic process (GO:0045072)3.13723134
87germinal center formation (GO:0002467)3.12859933
88response to laminar fluid shear stress (GO:0034616)3.11502139
89tolerance induction (GO:0002507)3.09681530
90regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06697425
91adenosine receptor signaling pathway (GO:0001973)3.06051070
92regulation of interleukin-8 biosynthetic process (GO:0045414)3.05406753
93myeloid leukocyte activation (GO:0002274)3.05026310
94negative regulation of cytokine production involved in immune response (GO:0002719)3.04803414
95positive regulation of cellular amide metabolic process (GO:0034250)3.04703451
96macrophage chemotaxis (GO:0048246)3.02897221
97sodium-independent organic anion transport (GO:0043252)3.00139113
98antigen processing and presentation of endogenous antigen (GO:0019883)2.98602706
99regulation of granulocyte differentiation (GO:0030852)2.98078066
100positive regulation of SMAD protein import into nucleus (GO:0060391)2.97386051
101regulation of regulated secretory pathway (GO:1903305)2.94924225
102positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.90878179
103positive regulation of gamma-delta T cell activation (GO:0046645)2.90766051
104receptor catabolic process (GO:0032801)2.87483965
105negative regulation of B cell proliferation (GO:0030889)2.87164986
106positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86268296
107regulation of T-helper 2 cell differentiation (GO:0045628)2.84487061
108regulation of chemokine-mediated signaling pathway (GO:0070099)2.84002160
109myeloid dendritic cell differentiation (GO:0043011)2.81380895
110positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80569697
111response to sterol (GO:0036314)2.79862823
112phagocytosis, engulfment (GO:0006911)2.79839347
113myeloid dendritic cell activation (GO:0001773)2.79363917
114regulation of mast cell degranulation (GO:0043304)2.79301591
115regulation of T cell tolerance induction (GO:0002664)2.78967852
116negative regulation of bone remodeling (GO:0046851)2.76755902
117positive regulation of monocyte chemotaxis (GO:0090026)2.76341258
118regulation of B cell differentiation (GO:0045577)2.76062577
119lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74947599
120positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.74300509
121NIK/NF-kappaB signaling (GO:0038061)2.72541856
122cortical actin cytoskeleton organization (GO:0030866)2.72226588
123pinocytosis (GO:0006907)2.71770119
124negative regulation of interleukin-17 production (GO:0032700)2.70826768
125positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.69805715
126antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69448084
127defense response to protozoan (GO:0042832)2.69347518
128regulation of erythrocyte differentiation (GO:0045646)2.69055907
129negative regulation of erythrocyte differentiation (GO:0045647)2.68500994
130positive regulation of erythrocyte differentiation (GO:0045648)2.67888862
131regulation of mast cell activation involved in immune response (GO:0033006)2.67324729
132neutrophil migration (GO:1990266)2.66971822
133monocyte chemotaxis (GO:0002548)2.66772957
134negative regulation of macrophage differentiation (GO:0045650)2.65698676
135positive regulation of chemokine biosynthetic process (GO:0045080)2.65472465
136barbed-end actin filament capping (GO:0051016)2.65387814
137B cell receptor signaling pathway (GO:0050853)2.65161223
138response to thyroid hormone (GO:0097066)2.64847010
139regulation of tolerance induction (GO:0002643)2.64744777
140regulation of gamma-delta T cell differentiation (GO:0045586)2.64676084
141negative regulation of toll-like receptor signaling pathway (GO:0034122)2.64243726
142negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.63307791
143cyclooxygenase pathway (GO:0019371)2.57881669
144negative regulation of interleukin-12 production (GO:0032695)2.55849977
145dendritic cell differentiation (GO:0097028)2.54083256
146granulocyte activation (GO:0036230)2.53745298
147neutrophil chemotaxis (GO:0030593)2.53593194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.52317513
2IRF8_27001747_Chip-Seq_BMDM_Mouse4.79686844
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.67693211
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.27302601
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.89360041
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.87685653
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.38820146
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.34750909
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.31662019
10SCL_19346495_ChIP-Seq_HPC-7_Human3.18383565
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.99473275
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.91906452
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83935618
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59422253
15* SPI1_23127762_ChIP-Seq_K562_Human2.57185229
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.53464758
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37519024
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.36033984
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31854291
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19442107
21RUNX_20019798_ChIP-Seq_JUKART_Human2.14669362
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09982377
23VDR_24763502_ChIP-Seq_THP-1_Human2.06417927
24VDR_21846776_ChIP-Seq_THP-1_Human2.04152986
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.02714666
26VDR_24787735_ChIP-Seq_THP-1_Human1.92140462
27NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.90063034
28* SPI1_23547873_ChIP-Seq_NB4_Human1.81756163
29* TCF7_22412390_ChIP-Seq_EML_Mouse1.80673945
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78000233
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76073378
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68985523
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64503664
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61969201
35* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59810681
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59778707
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.59000683
38GATA1_22025678_ChIP-Seq_K562_Human1.56942654
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53775732
40* PU_27001747_Chip-Seq_BMDM_Mouse1.50426075
41* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45210951
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45106638
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.41923244
44MAF_26560356_Chip-Seq_TH1_Human1.41475991
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39343619
46GATA1_19941826_ChIP-Seq_K562_Human1.39124163
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37974755
48KDM2B_26808549_Chip-Seq_DND41_Human1.37317923
49MYC_22102868_ChIP-Seq_BL_Human1.35961224
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.35292035
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34234379
52GATA2_19941826_ChIP-Seq_K562_Human1.30187460
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.29920050
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28164606
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26557481
56LXR_22292898_ChIP-Seq_THP-1_Human1.25724739
57MYB_26560356_Chip-Seq_TH2_Human1.25510312
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23677624
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22756552
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.22463779
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19607111
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19301375
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16634084
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.16474108
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16134338
66* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12972897
67MYB_26560356_Chip-Seq_TH1_Human1.12397516
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11347432
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11304985
70MAF_26560356_Chip-Seq_TH2_Human1.09032225
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.08515786
72UTX_26944678_Chip-Seq_JUKART_Human1.08183455
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07679414
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07553758
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07553758
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07553758
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07318970
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06536387
79GATA3_27048872_Chip-Seq_THYMUS_Human1.04946618
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04222568
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02144639
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01898892
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01527990
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01233154
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.00181543
86WT1_19549856_ChIP-ChIP_CCG9911_Human0.99742656
87STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99606250
88CDX2_20551321_ChIP-Seq_CACO-2_Human0.98360175
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94878330
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94694112
91* BCL6_27268052_Chip-Seq_Bcells_Human0.93027875
92BCOR_27268052_Chip-Seq_Bcells_Human0.91187933
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90203890
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89799163
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89197993
96* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87997100
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87718640
98TFEB_21752829_ChIP-Seq_HELA_Human0.87653241
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87448774
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87310753
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87292890
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86406361
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86384842
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.85473888
105STAT1_20625510_ChIP-Seq_HELA_Human0.85441483
106SPI1_20517297_ChIP-Seq_HL60_Human0.84860324
107CLOCK_20551151_ChIP-Seq_293T_Human0.84121472
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83755683
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83583842
110KDM2B_26808549_Chip-Seq_K562_Human0.81822585
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81775766
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81720708
113GATA3_26560356_Chip-Seq_TH2_Human0.81681053
114FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80467993
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.80066640
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.79079283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.21104311
2MP0006082_CNS_inflammation5.07436417
3MP0003191_abnormal_cellular_cholesterol4.96083435
4MP0003172_abnormal_lysosome_physiology4.13203875
5MP0003303_peritoneal_inflammation3.66329876
6MP0001835_abnormal_antigen_presentation3.20750501
7MP0009840_abnormal_foam_cell3.08509031
8MP0003690_abnormal_glial_cell2.85123944
9MP0005671_abnormal_response_to2.84667333
10MP0005464_abnormal_platelet_physiology2.80472491
11MP0002419_abnormal_innate_immunity2.73050850
12MP0003075_altered_response_to2.50653083
13MP0003300_gastrointestinal_ulcer2.39478904
14MP0003436_decreased_susceptibility_to2.30247682
15MP0003183_abnormal_peptide_metabolism2.15703443
16MP0005000_abnormal_immune_tolerance2.06699372
17* MP0002452_abnormal_antigen_presenting2.05508797
18MP0003724_increased_susceptibility_to1.95802330
19MP0000343_altered_response_to1.92421880
20MP0008004_abnormal_stomach_pH1.85912572
21* MP0002723_abnormal_immune_serum1.85622326
22MP0001800_abnormal_humoral_immune1.85183721
23MP0001851_eye_inflammation1.84601685
24MP0002148_abnormal_hypersensitivity_rea1.84460951
25MP0009278_abnormal_bone_marrow1.83269243
26MP0009764_decreased_sensitivity_to1.76651339
27MP0005025_abnormal_response_to1.75538087
28MP0005167_abnormal_blood-brain_barrier1.73330339
29MP0002928_abnormal_bile_duct1.66024313
30MP0002420_abnormal_adaptive_immunity1.65582907
31* MP0001819_abnormal_immune_cell1.65156983
32MP0000465_gastrointestinal_hemorrhage1.63683674
33MP0005166_decreased_susceptibility_to1.60436115
34MP0003566_abnormal_cell_adhesion1.59157694
35MP0004185_abnormal_adipocyte_glucose1.58478124
36MP0004510_myositis1.56409342
37MP0005670_abnormal_white_adipose1.56329571
38MP0005387_immune_system_phenotype1.53807574
39MP0001790_abnormal_immune_system1.53807574
40* MP0001533_abnormal_skeleton_physiology1.49373875
41* MP0008469_abnormal_protein_level1.47071261
42MP0001845_abnormal_inflammatory_respons1.42715360
43MP0005451_abnormal_body_composition1.42556678
44MP0003252_abnormal_bile_duct1.42316101
45MP0002139_abnormal_hepatobiliary_system1.41078075
46MP0008260_abnormal_autophagy1.40050743
47MP0000858_altered_metastatic_potential1.36639562
48MP0002090_abnormal_vision1.35171015
49MP0001915_intracranial_hemorrhage1.34605457
50MP0000685_abnormal_immune_system1.33539589
51MP0003045_fibrosis1.28698795
52MP0002405_respiratory_system_inflammati1.28632175
53MP0009785_altered_susceptibility_to1.24969654
54MP0005397_hematopoietic_system_phenotyp1.24469251
55MP0001545_abnormal_hematopoietic_system1.24469251
56MP0004883_abnormal_blood_vessel1.24356915
57MP0000604_amyloidosis1.23917875
58MP0009333_abnormal_splenocyte_physiolog1.23424519
59* MP0000689_abnormal_spleen_morphology1.20511490
60MP0000569_abnormal_digit_pigmentation1.20249891
61* MP0000716_abnormal_immune_system1.18744379
62MP0003329_amyloid_beta_deposits1.18650048
63MP0000767_abnormal_smooth_muscle1.10871055
64MP0000249_abnormal_blood_vessel1.09608076
65MP0002396_abnormal_hematopoietic_system1.07340659
66MP0005310_abnormal_salivary_gland1.04810637
67MP0004947_skin_inflammation1.04796763
68MP0003828_pulmonary_edema1.04093202
69MP0002254_reproductive_system_inflammat1.03568389
70MP0005023_abnormal_wound_healing1.03438362
71MP0001853_heart_inflammation1.02322301
72MP0003279_aneurysm1.01749827
73* MP0002398_abnormal_bone_marrow1.01716063
74MP0002166_altered_tumor_susceptibility1.01572027
75MP0003806_abnormal_nucleotide_metabolis1.01409515
76MP0008873_increased_physiological_sensi1.01353366
77MP0008007_abnormal_cellular_replicative1.00739090
78* MP0002998_abnormal_bone_remodeling1.00336628
79MP0000920_abnormal_myelination1.00055494
80MP0005666_abnormal_adipose_tissue0.99691137
81* MP0002722_abnormal_immune_system0.95143736
82* MP0002429_abnormal_blood_cell0.94723218
83MP0004130_abnormal_muscle_cell0.94554585
84MP0003656_abnormal_erythrocyte_physiolo0.93880335
85MP0003633_abnormal_nervous_system0.92388926
86MP0010155_abnormal_intestine_physiology0.91749784
87MP0003195_calcinosis0.89469676
88MP0003448_altered_tumor_morphology0.87380852
89MP0003634_abnormal_glial_cell0.86484429
90MP0005165_increased_susceptibility_to0.84184649
91MP0006054_spinal_hemorrhage0.83508446
92MP0008438_abnormal_cutaneous_collagen0.82406645
93MP0003091_abnormal_cell_migration0.81577306
94* MP0005390_skeleton_phenotype0.79827226
95MP0008874_decreased_physiological_sensi0.78903285
96MP0005164_abnormal_response_to0.78680179
97MP0000609_abnormal_liver_physiology0.78658976
98MP0003453_abnormal_keratinocyte_physiol0.76938981
99* MP0003795_abnormal_bone_structure0.76859831
100MP0001663_abnormal_digestive_system0.76600556
101MP0003763_abnormal_thymus_physiology0.76461047
102MP0009763_increased_sensitivity_to0.75931660
103MP0003866_abnormal_defecation0.73763928
104MP0002138_abnormal_hepatobiliary_system0.71805104
105MP0005365_abnormal_bile_salt0.69778977
106MP0002277_abnormal_respiratory_mucosa0.68849134
107MP0003705_abnormal_hypodermis_morpholog0.66957023
108MP0004808_abnormal_hematopoietic_stem0.66160993
109MP0003638_abnormal_response/metabolism_0.65679901
110MP0002933_joint_inflammation0.65014570
111MP0010307_abnormal_tumor_latency0.64001561
112MP0005085_abnormal_gallbladder_physiolo0.63977384
113MP0002006_tumorigenesis0.63358888
114MP0000598_abnormal_liver_morphology0.63161724
115MP0001873_stomach_inflammation0.62740412
116MP0002135_abnormal_kidney_morphology0.62659694
117MP0005197_abnormal_uvea_morphology0.62562810
118MP0009115_abnormal_fat_cell0.62200536
119MP0002136_abnormal_kidney_physiology0.61264351
120MP0002332_abnormal_exercise_endurance0.59136340
121MP0005595_abnormal_vascular_smooth0.58277511
122MP0009765_abnormal_xenobiotic_induced0.57952621
123MP0000015_abnormal_ear_pigmentation0.57698579
124MP0001986_abnormal_taste_sensitivity0.56126304
125MP0003879_abnormal_hair_cell0.54334603
126MP0002971_abnormal_brown_adipose0.53069394
127MP0005584_abnormal_enzyme/coenzyme_acti0.52778780
128MP0000371_diluted_coat_color0.51753495

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)9.99612588
2Glomerulonephritis (HP:0000099)8.29873208
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.21750017
4Abnormality of glycolipid metabolism (HP:0010969)7.21750017
5Abnormality of liposaccharide metabolism (HP:0010968)7.21750017
6Complement deficiency (HP:0004431)6.53077392
7Increased cerebral lipofuscin (HP:0011813)5.74891758
8Increased neuronal autofluorescent lipopigment (HP:0002074)5.15047250
9Arterial tortuosity (HP:0005116)5.10153114
10Cerebral aneurysm (HP:0004944)5.05775383
11Dysostosis multiplex (HP:0000943)5.04435593
12Abnormality of complement system (HP:0005339)5.00597452
13Recurrent abscess formation (HP:0002722)4.79142030
14Recurrent bacterial skin infections (HP:0005406)4.58791864
15Retinal atrophy (HP:0001105)4.53977957
16Vascular tortuosity (HP:0004948)4.46478620
17Nephritis (HP:0000123)4.24778735
18Hematochezia (HP:0002573)4.14977706
19Disinhibition (HP:0000734)3.95469187
20Eczematoid dermatitis (HP:0000976)3.94698843
21Vacuolated lymphocytes (HP:0001922)3.87061083
22Axonal loss (HP:0003447)3.82728448
23Mucopolysacchariduria (HP:0008155)3.81274561
24Urinary glycosaminoglycan excretion (HP:0003541)3.81274561
25Abnormality of polysaccharide metabolism (HP:0011012)3.61995215
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.61995215
27Abnormality of mucopolysaccharide metabolism (HP:0011020)3.61995215
28Aortic aneurysm (HP:0004942)3.56185583
29Orchitis (HP:0100796)3.52525442
30Urethral obstruction (HP:0000796)3.46618899
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.32753706
32Agnosia (HP:0010524)3.30924039
33Retrobulbar optic neuritis (HP:0100654)3.25564662
34Optic neuritis (HP:0100653)3.25564662
35Disproportionate tall stature (HP:0001519)3.23652438
36Recurrent gram-negative bacterial infections (HP:0005420)3.19379643
37Orthostatic hypotension (HP:0001278)3.14426711
38Stomatitis (HP:0010280)3.09916021
39Colitis (HP:0002583)3.09075299
40Neurofibrillary tangles (HP:0002185)2.95366944
41Progressive neurologic deterioration (HP:0002344)2.94745978
42Striae distensae (HP:0001065)2.93409381
43Upper motor neuron abnormality (HP:0002127)2.93261000
44Purpura (HP:0000979)2.86284004
45Hepatosplenomegaly (HP:0001433)2.85455726
46Chronic mucocutaneous candidiasis (HP:0002728)2.84419474
47Recurrent cutaneous fungal infections (HP:0011370)2.84419474
48Abnormality of macrophages (HP:0004311)2.81046655
49Abnormality of the vasculature of the conjunctiva (HP:0008054)2.76877639
50Chronic diarrhea (HP:0002028)2.70390385
51Aortic dissection (HP:0002647)2.69641771
52Autoimmune thrombocytopenia (HP:0001973)2.64201866
53Meningitis (HP:0001287)2.62682555
54Recurrent skin infections (HP:0001581)2.59976594
55Pathologic fracture (HP:0002756)2.58339573
56Hemoptysis (HP:0002105)2.57996917
57Asymmetric septal hypertrophy (HP:0001670)2.52396846
58Pulmonary infiltrates (HP:0002113)2.48067194
59Amyloidosis (HP:0011034)2.45977977
60Increased serum ferritin (HP:0003281)2.44081185
61Loss of speech (HP:0002371)2.43679873
62Inflammation of the large intestine (HP:0002037)2.41940181
63Thoracic kyphosis (HP:0002942)2.41650899
64Cardiomegaly (HP:0001640)2.41546841
65Spondylolisthesis (HP:0003302)2.41280526
66Vasculitis (HP:0002633)2.35796930
67Nuclear cataract (HP:0100018)2.34795421
68Petechiae (HP:0000967)2.32638172
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30992697
70Elevated erythrocyte sedimentation rate (HP:0003565)2.30902271
71* Mutism (HP:0002300)2.27709868
72Arnold-Chiari malformation (HP:0002308)2.27345678
73Urticaria (HP:0001025)2.26869225
74Keratoconjunctivitis sicca (HP:0001097)2.25177467
75Mitral valve prolapse (HP:0001634)2.24155943
76Gastrointestinal inflammation (HP:0004386)2.23777673
77Epistaxis (HP:0000421)2.20819961
78Inappropriate behavior (HP:0000719)2.19134312
79Myocardial infarction (HP:0001658)2.18938776
80Abnormal platelet function (HP:0011869)2.18715347
81Impaired platelet aggregation (HP:0003540)2.18715347
82Malnutrition (HP:0004395)2.15364458
83Apathy (HP:0000741)2.14990286
84Pustule (HP:0200039)2.13989781
85Basal ganglia calcification (HP:0002135)2.13189772
86Increased IgE level (HP:0003212)2.12652779
87Abnormality of iron homeostasis (HP:0011031)2.09950732
88Encephalitis (HP:0002383)2.09901787
89Spontaneous hematomas (HP:0007420)2.09404389
90Myositis (HP:0100614)2.08891580
91Cerebral inclusion bodies (HP:0100314)2.08592475
92* Neuronal loss in central nervous system (HP:0002529)2.08447429
93Peripheral demyelination (HP:0011096)2.04740988
94Increased CSF protein (HP:0002922)2.03564570
95Diminished motivation (HP:0000745)2.02970983
96Keratoconjunctivitis (HP:0001096)2.02791591
97Polyneuropathy (HP:0001271)2.02464119
98Polygenic inheritance (HP:0010982)2.00572996
99Joint stiffness (HP:0001387)1.99976648
100J-shaped sella turcica (HP:0002680)1.98231486
101Gastrointestinal infarctions (HP:0005244)1.96983604
102Intestinal fistula (HP:0100819)1.95284756
103Pulmonary embolism (HP:0002204)1.95169451
104Leukocytosis (HP:0001974)1.94738089
105T lymphocytopenia (HP:0005403)1.94608451
106Conjunctival telangiectasia (HP:0000524)1.92784771
107Rectovaginal fistula (HP:0000143)1.91730242
108Rectal fistula (HP:0100590)1.91730242
109Urinary incontinence (HP:0000020)1.90592764
110Abnormal delayed hypersensitivity skin test (HP:0002963)1.90396381
111Interstitial pulmonary disease (HP:0006530)1.90165539
112Abnormality of the lumbar spine (HP:0100712)1.87575585
113Gingival bleeding (HP:0000225)1.86987901
114Gingivitis (HP:0000230)1.86945961
115Bicuspid aortic valve (HP:0001647)1.86924640
116Prolonged bleeding time (HP:0003010)1.86734699
117Recurrent fungal infections (HP:0002841)1.85907012
118Global brain atrophy (HP:0002283)1.84186775
119Vaginal fistula (HP:0004320)1.83687662
120Cellulitis (HP:0100658)1.83043768
121Obstructive lung disease (HP:0006536)1.80564381
122Chronic obstructive pulmonary disease (HP:0006510)1.80564381
123Progressive visual loss (HP:0000529)1.79429803
124Abnormality of the thoracic spine (HP:0100711)1.76617002
125Personality changes (HP:0000751)1.76133063
126Ovoid vertebral bodies (HP:0003300)1.75714913
127Bone pain (HP:0002653)1.74426585
128Exotropia (HP:0000577)1.73708128
129Recurrent viral infections (HP:0004429)1.73218105
130Clumsiness (HP:0002312)1.71620886
131Thickened calvaria (HP:0002684)1.69377312
132Mediastinal lymphadenopathy (HP:0100721)1.69311901
133Thick nail (HP:0001805)1.67424971
134Lower limb asymmetry (HP:0100559)1.66651913
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.62793235
136Osteolytic defects of the hand bones (HP:0009699)1.62793235
137Osteomyelitis (HP:0002754)1.61144317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR28.26860658
2MAPK156.57309393
3GRK73.41032213
4TSSK63.10811319
5TYK22.77872844
6RIPK42.55752777
7PAK42.46938803
8CAMK1D2.34726462
9PRPF4B2.31169994
10BLK2.23383188
11TBK11.89258258
12CAMK1G1.86885422
13ERN11.86790882
14VRK11.81672513
15IRAK41.67964368
16MAP3K111.62552219
17NME21.58647429
18CLK11.55610302
19STK101.54062771
20CDC42BPA1.51992504
21JAK11.51103436
22IRAK31.50649515
23TAOK11.47296393
24DDR21.39538068
25PKN21.36968991
26TNK21.36709066
27MAP4K11.36394264
28MATK1.33068472
29EPHB11.32879194
30TAOK21.31027449
31FES1.30473045
32MAP2K31.27852409
33HCK1.27720858
34CAMKK21.24489374
35ZAP701.20544093
36PAK21.15646109
37CSK1.15597911
38MAPK121.15346913
39MAP3K11.14228489
40MOS1.13209830
41KIT1.11775152
42* CSF1R1.09957794
43JAK21.05219626
44EEF2K1.02496609
45CDK30.96589414
46PTK60.94689744
47BMPR20.93289197
48TRIB30.89701350
49PDK20.88314601
50CAMKK10.87638683
51LCK0.87494436
52MAP3K140.87144529
53SCYL20.86487614
54MAP3K90.84764736
55ITK0.83761430
56LYN0.81760460
57NEK90.81292382
58IKBKB0.80893198
59ACVR1B0.78897360
60TESK20.77795787
61MAP3K130.77518204
62MARK20.76896674
63MAP3K30.76590073
64KSR20.73165691
65CDK60.73105314
66PDK10.72272281
67SYK0.71140272
68SIK30.70619273
69ADRBK20.69683609
70MAPK70.68296853
71MAP3K100.66169809
72IRAK20.65902974
73FGR0.65540037
74ABL20.65389042
75SIK20.65323377
76CAMK40.63306316
77GSK3A0.61409193
78ICK0.60441074
79BTK0.60232284
80PIK3CG0.60202698
81PDPK10.57780204
82GRK50.56949472
83MAP3K50.55781982
84IRAK10.55683457
85TEC0.55325592
86PRKD20.54748548
87MAPKAPK20.54568001
88ARAF0.53870036
89RPS6KC10.52600598
90RPS6KL10.52600598
91MAPKAPK30.51411316
92MAPKAPK50.47444705
93DAPK20.47237064
94EGFR0.46929426
95GRK60.45255640
96IKBKE0.44926269
97TGFBR10.44325867
98PIM20.43044534
99MARK30.40931603
100RPS6KA60.40380285
101TAOK30.40280958
102TRPM70.39408817
103PRKD10.38637058
104PRKG20.37544855
105ABL10.37498543
106RIPK10.35167346
107MAPK40.34402719
108MAP2K60.34035250
109JAK30.32750868
110TYRO30.32743076
111STK110.32733926
112PIM10.31708756
113PTK2B0.31328027
114RPS6KA20.31275553
115MAP2K20.30693147
116RET0.30534340
117TXK0.29920129
118* IGF1R0.28848383
119RPS6KA40.28123681
120PRKAA20.24388483
121MELK0.22584956
122YES10.21232201
123PRKCD0.21001921
124FYN0.20795141
125MAP3K80.19403809
126CHUK0.19372573
127PDGFRB0.18948722
128SGK30.17870929
129SRC0.17405845
130TTN0.16867940
131PKN10.16659708
132MAP3K60.16447301
133FGFR30.15990049

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.97753050
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.90122147
3Other glycan degradation_Homo sapiens_hsa005114.50729824
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.40884092
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.36457651
6Lysosome_Homo sapiens_hsa041423.18817907
7* Osteoclast differentiation_Homo sapiens_hsa043802.53576418
8Prion diseases_Homo sapiens_hsa050202.39504652
9Pertussis_Homo sapiens_hsa051332.39078245
10Allograft rejection_Homo sapiens_hsa053302.37956611
11Asthma_Homo sapiens_hsa053102.35102563
12Leishmaniasis_Homo sapiens_hsa051402.33474006
13Graft-versus-host disease_Homo sapiens_hsa053322.22488227
14Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.20951218
15B cell receptor signaling pathway_Homo sapiens_hsa046622.17181089
16Autoimmune thyroid disease_Homo sapiens_hsa053202.08996311
17Antigen processing and presentation_Homo sapiens_hsa046122.01312806
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86660663
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84053931
20Type I diabetes mellitus_Homo sapiens_hsa049401.68768835
21Complement and coagulation cascades_Homo sapiens_hsa046101.62606175
22Tuberculosis_Homo sapiens_hsa051521.58834025
23Legionellosis_Homo sapiens_hsa051341.49340823
24Toxoplasmosis_Homo sapiens_hsa051451.44751549
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25316548
26Nitrogen metabolism_Homo sapiens_hsa009101.24391265
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16274593
28Phagosome_Homo sapiens_hsa041451.14788510
29Measles_Homo sapiens_hsa051621.14496804
30Influenza A_Homo sapiens_hsa051641.12192847
31Chronic myeloid leukemia_Homo sapiens_hsa052201.10267610
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09975578
33Chemokine signaling pathway_Homo sapiens_hsa040621.07298156
34Pancreatic cancer_Homo sapiens_hsa052121.06866898
35Malaria_Homo sapiens_hsa051441.03224937
36Salmonella infection_Homo sapiens_hsa051321.00130206
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95952742
38Rheumatoid arthritis_Homo sapiens_hsa053230.95233348
39Colorectal cancer_Homo sapiens_hsa052100.93068393
40Platelet activation_Homo sapiens_hsa046110.91721664
41Renal cell carcinoma_Homo sapiens_hsa052110.91305800
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.90558245
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89284927
44Primary immunodeficiency_Homo sapiens_hsa053400.88673136
45Collecting duct acid secretion_Homo sapiens_hsa049660.88380488
46* Endocytosis_Homo sapiens_hsa041440.85500879
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.85130690
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84274867
49ABC transporters_Homo sapiens_hsa020100.82587703
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.81350878
51Hepatitis B_Homo sapiens_hsa051610.77702140
52Apoptosis_Homo sapiens_hsa042100.77509978
53Estrogen signaling pathway_Homo sapiens_hsa049150.73889125
54TNF signaling pathway_Homo sapiens_hsa046680.72989757
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69945682
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69279512
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66445510
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65803573
59Shigellosis_Homo sapiens_hsa051310.65006080
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64741312
61Notch signaling pathway_Homo sapiens_hsa043300.63970950
62Mineral absorption_Homo sapiens_hsa049780.60621628
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60541707
64T cell receptor signaling pathway_Homo sapiens_hsa046600.58086827
65Amoebiasis_Homo sapiens_hsa051460.58004136
66African trypanosomiasis_Homo sapiens_hsa051430.55491649
67* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55438789
68Acute myeloid leukemia_Homo sapiens_hsa052210.54714506
69* Hematopoietic cell lineage_Homo sapiens_hsa046400.54283985
70Adherens junction_Homo sapiens_hsa045200.52821256
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52780891
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.52037139
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51759790
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51736897
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.51526329
76Ether lipid metabolism_Homo sapiens_hsa005650.51491636
77Bladder cancer_Homo sapiens_hsa052190.50665713
78Type II diabetes mellitus_Homo sapiens_hsa049300.50117420
79MAPK signaling pathway_Homo sapiens_hsa040100.49451910
80Galactose metabolism_Homo sapiens_hsa000520.46155204
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46055012
82VEGF signaling pathway_Homo sapiens_hsa043700.44662866
83Vibrio cholerae infection_Homo sapiens_hsa051100.43158313
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.42146495
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39925066
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39820738
87Non-small cell lung cancer_Homo sapiens_hsa052230.38590983
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37658800
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37519358
90PPAR signaling pathway_Homo sapiens_hsa033200.37172562
91Glioma_Homo sapiens_hsa052140.36971994
92Herpes simplex infection_Homo sapiens_hsa051680.36532466
93Choline metabolism in cancer_Homo sapiens_hsa052310.35542970
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35326121
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34422846
96Hepatitis C_Homo sapiens_hsa051600.33942088
97* Rap1 signaling pathway_Homo sapiens_hsa040150.32945705
98HTLV-I infection_Homo sapiens_hsa051660.32852928
99Focal adhesion_Homo sapiens_hsa045100.32240518
100Inositol phosphate metabolism_Homo sapiens_hsa005620.32082948
101Renin secretion_Homo sapiens_hsa049240.31401057
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.31290568
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31107464
104Systemic lupus erythematosus_Homo sapiens_hsa053220.30563465
105Dorso-ventral axis formation_Homo sapiens_hsa043200.30486893
106Insulin resistance_Homo sapiens_hsa049310.30203375
107HIF-1 signaling pathway_Homo sapiens_hsa040660.30023966
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29810952
109Viral myocarditis_Homo sapiens_hsa054160.29745489
110GnRH signaling pathway_Homo sapiens_hsa049120.29647827
111Epstein-Barr virus infection_Homo sapiens_hsa051690.29525680
112FoxO signaling pathway_Homo sapiens_hsa040680.29273183
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.28366315
114Proteoglycans in cancer_Homo sapiens_hsa052050.24914787
115* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24781670
116Prolactin signaling pathway_Homo sapiens_hsa049170.24714058
117mTOR signaling pathway_Homo sapiens_hsa041500.23760279
118Renin-angiotensin system_Homo sapiens_hsa046140.23723069
119Sphingolipid metabolism_Homo sapiens_hsa006000.21779434
120ErbB signaling pathway_Homo sapiens_hsa040120.21088112
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.20427450
122Caffeine metabolism_Homo sapiens_hsa002320.20201118

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