CSF2RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.89789273
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.89789273
3modulation by symbiont of host immune response (GO:0052553)6.89789273
4positive regulation by symbiont of host defense response (GO:0052509)6.89789273
5modulation by symbiont of host defense response (GO:0052031)6.89789273
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.89789273
7neutrophil activation involved in immune response (GO:0002283)5.74702547
8response to peptidoglycan (GO:0032494)5.70347263
9branching involved in labyrinthine layer morphogenesis (GO:0060670)5.39042126
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.09441781
11macrophage activation involved in immune response (GO:0002281)5.05967814
12respiratory burst (GO:0045730)5.05333833
13response to host immune response (GO:0052572)4.72465901
14response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.72465901
15regulation of interferon-beta biosynthetic process (GO:0045357)4.60741587
16immunoglobulin mediated immune response (GO:0016064)4.59360715
17response to muramyl dipeptide (GO:0032495)4.42049483
18production of molecular mediator involved in inflammatory response (GO:0002532)4.28710930
19response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.24215865
20response to host (GO:0075136)4.24215865
21response to host defenses (GO:0052200)4.24215865
22neutrophil activation (GO:0042119)4.23932451
23granulocyte activation (GO:0036230)4.22256802
24neutrophil mediated immunity (GO:0002446)4.15697026
25positive regulation of interferon-alpha production (GO:0032727)4.15212944
26cellular extravasation (GO:0045123)4.08405605
27positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.04224024
28leukocyte aggregation (GO:0070486)4.01155073
29regulation of mast cell degranulation (GO:0043304)3.96468756
30regulation of interferon-alpha production (GO:0032647)3.93017202
31positive regulation of gamma-delta T cell activation (GO:0046645)3.91985107
32regulation of B cell receptor signaling pathway (GO:0050855)3.82615394
33positive regulation of mast cell activation (GO:0033005)3.81609986
34positive regulation of mast cell degranulation (GO:0043306)3.81583437
35positive regulation of mast cell activation involved in immune response (GO:0033008)3.81583437
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.80215510
37myeloid cell activation involved in immune response (GO:0002275)3.79828383
38negative regulation of interleukin-12 production (GO:0032695)3.74713793
39hydrogen peroxide biosynthetic process (GO:0050665)3.73180252
40positive regulation of antigen processing and presentation (GO:0002579)3.73108733
41microglial cell activation (GO:0001774)3.71388282
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69973210
43negative regulation of cell killing (GO:0031342)3.69973210
44regulation of mast cell activation involved in immune response (GO:0033006)3.68594548
45positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.63939963
46superoxide anion generation (GO:0042554)3.57092440
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56657673
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56657673
49antigen processing and presentation of endogenous antigen (GO:0019883)3.54239652
50reactive oxygen species biosynthetic process (GO:1903409)3.53461113
51macrophage activation (GO:0042116)3.51501229
52response to fungus (GO:0009620)3.49981319
53regulation of mast cell activation (GO:0033003)3.48987476
54regulation of leukocyte degranulation (GO:0043300)3.44406307
55negative regulation of mast cell activation (GO:0033004)3.43957852
56regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43328528
57positive regulation of cellular amide metabolic process (GO:0034250)3.42314986
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.36206458
59detection of molecule of bacterial origin (GO:0032490)3.36096231
60T-helper 1 type immune response (GO:0042088)3.32149809
61apoptotic cell clearance (GO:0043277)3.32141965
62DNA deamination (GO:0045006)3.30273474
63positive regulation of B cell differentiation (GO:0045579)3.28561878
64leukotriene metabolic process (GO:0006691)3.25682024
65regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.25167571
66interferon-gamma-mediated signaling pathway (GO:0060333)3.24339172
67leukocyte mediated cytotoxicity (GO:0001909)3.21421721
68neutrophil chemotaxis (GO:0030593)3.21014255
69B cell mediated immunity (GO:0019724)3.20815630
70detection of other organism (GO:0098543)3.19108780
71leukocyte migration involved in inflammatory response (GO:0002523)3.18340732
72defense response to protozoan (GO:0042832)3.17867933
73myeloid leukocyte mediated immunity (GO:0002444)3.17277557
74myeloid dendritic cell differentiation (GO:0043011)3.16285156
75regulation of antigen processing and presentation (GO:0002577)3.14804862
76myeloid dendritic cell activation (GO:0001773)3.11867001
77neutrophil migration (GO:1990266)3.11475112
78Arp2/3 complex-mediated actin nucleation (GO:0034314)3.08235494
79indolalkylamine catabolic process (GO:0046218)3.07899803
80tryptophan catabolic process (GO:0006569)3.07899803
81indole-containing compound catabolic process (GO:0042436)3.07899803
82positive regulation of interferon-beta production (GO:0032728)3.07703399
83cellular response to type I interferon (GO:0071357)3.07412123
84type I interferon signaling pathway (GO:0060337)3.07412123
85response to type I interferon (GO:0034340)3.06447170
86positive regulation of leukocyte degranulation (GO:0043302)3.04223870
87detection of external biotic stimulus (GO:0098581)3.02718895
88regulation of B cell differentiation (GO:0045577)3.02700094
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00309457
90leukocyte cell-cell adhesion (GO:0007159)3.00229838
91interferon-gamma secretion (GO:0072643)2.99967277
92germinal center formation (GO:0002467)2.99095500
93regulation of interleukin-8 biosynthetic process (GO:0045414)2.98524100
94positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.98219403
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97450385
96cellular response to zinc ion (GO:0071294)2.97156693
97positive regulation of defense response to virus by host (GO:0002230)2.96732344
98negative regulation of granulocyte differentiation (GO:0030853)2.96607107
99myeloid leukocyte activation (GO:0002274)2.96308224
100cellular response to exogenous dsRNA (GO:0071360)2.95395361
101positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94175416
102natural killer cell mediated immunity (GO:0002228)2.92939704
103natural killer cell mediated cytotoxicity (GO:0042267)2.92939704
104regulation of gamma-delta T cell activation (GO:0046643)2.92399967
105phagosome maturation (GO:0090382)2.91935751
106negative regulation of T cell mediated immunity (GO:0002710)2.91247782
107regulation of germinal center formation (GO:0002634)2.91000946
108regulation of integrin activation (GO:0033623)2.90322083
109detection of bacterium (GO:0016045)2.88584609
110positive regulation of chemokine biosynthetic process (GO:0045080)2.86997714
111kynurenine metabolic process (GO:0070189)2.86380736
112negative regulation of interleukin-17 production (GO:0032700)2.85703007
113NIK/NF-kappaB signaling (GO:0038061)2.85606565
114positive regulation of interleukin-1 beta secretion (GO:0050718)2.85556446
115regulation of interleukin-12 production (GO:0032655)2.85400575
116pinocytosis (GO:0006907)2.84994572
117regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84842627
118granulocyte chemotaxis (GO:0071621)2.84415012
119negative regulation of interleukin-6 production (GO:0032715)2.83592850
120negative regulation of interleukin-1 beta production (GO:0032691)2.83434850
121interferon-gamma production (GO:0032609)2.82878456
122positive regulation of toll-like receptor signaling pathway (GO:0034123)2.82830381
123regulation of regulated secretory pathway (GO:1903305)2.82187834
124regulation of interleukin-12 biosynthetic process (GO:0045075)2.82162479
125response to protozoan (GO:0001562)2.81921450
126positive regulation of NF-kappaB import into nucleus (GO:0042346)2.81539898
127positive regulation of T-helper 1 type immune response (GO:0002827)2.77447122
128regulation of MHC class II biosynthetic process (GO:0045346)2.77096963
129negative regulation of interleukin-1 production (GO:0032692)2.75361407
130detection of biotic stimulus (GO:0009595)2.72626066
131tryptophan metabolic process (GO:0006568)2.71287151
132regulation of hypersensitivity (GO:0002883)2.70734081
133positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70636164
134negative regulation of lymphocyte mediated immunity (GO:0002707)2.69742617
135positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.69376691
136regulation of T cell tolerance induction (GO:0002664)2.69144215
137positive regulation of interleukin-1 secretion (GO:0050716)2.67529563
138dendritic cell chemotaxis (GO:0002407)2.66609325
139regulation of interleukin-1 beta secretion (GO:0050706)2.66505021
140negative regulation of innate immune response (GO:0045824)2.63965748
141regulation of interleukin-6 biosynthetic process (GO:0045408)2.62840022
142negative regulation of Rho protein signal transduction (GO:0035024)2.62283613
143regulation of tolerance induction (GO:0002643)2.59598359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.31158661
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.86800270
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.65038006
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.39221224
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.37002856
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.87073205
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.78169159
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.76635475
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.63966094
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.45607671
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.37535511
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23041279
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13244833
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.70794110
15* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67161809
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66088447
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.61385621
18VDR_21846776_ChIP-Seq_THP-1_Human2.59078633
19SPI1_23547873_ChIP-Seq_NB4_Human2.57533474
20SCL_19346495_ChIP-Seq_HPC-7_Human2.55097516
21VDR_24763502_ChIP-Seq_THP-1_Human2.49554277
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40663477
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37546625
24SPI1_23127762_ChIP-Seq_K562_Human2.32783061
25* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27640297
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19776426
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18314602
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15945104
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.07238519
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05017471
31* RUNX1_22412390_ChIP-Seq_EML_Mouse2.03811458
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94821896
33MAF_26560356_Chip-Seq_TH1_Human1.88440475
34* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86833339
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84709794
36MYB_26560356_Chip-Seq_TH2_Human1.83118788
37CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.80906680
38PU_27001747_Chip-Seq_BMDM_Mouse1.78514592
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78494427
40RUNX_20019798_ChIP-Seq_JUKART_Human1.73403959
41MYC_22102868_ChIP-Seq_BL_Human1.73050106
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72206204
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71866456
44* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69831360
45VDR_24787735_ChIP-Seq_THP-1_Human1.68361814
46ZNF274_21170338_ChIP-Seq_K562_Hela1.68000588
47* TCF7_22412390_ChIP-Seq_EML_Mouse1.67853864
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66414625
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56962138
50MYB_26560356_Chip-Seq_TH1_Human1.56893654
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.55967725
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55185003
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50726044
54UTX_26944678_Chip-Seq_JUKART_Human1.49720272
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.44617033
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42203720
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41873030
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39145289
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38250212
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.35102268
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34906984
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34426558
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31343669
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.29120494
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25923583
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25735922
67* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25504383
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24426132
69EZH2_22144423_ChIP-Seq_EOC_Human1.22476487
70GATA3_27048872_Chip-Seq_THYMUS_Human1.20493335
71KDM2B_26808549_Chip-Seq_DND41_Human1.20290171
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20005182
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19713474
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.17940678
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17531118
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17299568
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.15837753
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14236079
79STAT1_20625510_ChIP-Seq_HELA_Human1.13608735
80SMRT_27268052_Chip-Seq_Bcells_Human1.12624313
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09713363
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09706529
83LXR_22292898_ChIP-Seq_THP-1_Human1.09516903
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09117367
85GATA3_26560356_Chip-Seq_TH2_Human1.07404819
86GATA1_22025678_ChIP-Seq_K562_Human1.05318542
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05089847
88MAF_26560356_Chip-Seq_TH2_Human1.04975314
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03994958
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.03005351
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01791890
92GATA3_21878914_ChIP-Seq_MCF-7_Human1.01311036
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97557804
94TFEB_21752829_ChIP-Seq_HELA_Human0.97279981
95ER_23166858_ChIP-Seq_MCF-7_Human0.96225544
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95542116
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94764970
98VDR_22108803_ChIP-Seq_LS180_Human0.94084768
99* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93818835
100GATA1_19941826_ChIP-Seq_K562_Human0.93776804
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93508847
102* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93280138
103IRF1_19129219_ChIP-ChIP_H3396_Human0.92380435
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89895152
105GATA2_19941826_ChIP-Seq_K562_Human0.89797095
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89387295
107SPI1_20517297_ChIP-Seq_HL60_Human0.89097958
108TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88569759
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87406514
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86537897
111TAF2_19829295_ChIP-Seq_ESCs_Human0.86267843
112TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85133222
113NANOG_20526341_ChIP-Seq_ESCs_Human0.84637447
114P300_27268052_Chip-Seq_Bcells_Human0.84142310
115ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83722291
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82596687
117BCAT_22108803_ChIP-Seq_LS180_Human0.82498320
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81135679
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80734834
120GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79873305
121RAC3_21632823_ChIP-Seq_H3396_Human0.79801622
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79392154
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76684494
124NCOR_22424771_ChIP-Seq_293T_Human0.76098945
125RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76003631
126* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75489469
127BCL6_27268052_Chip-Seq_Bcells_Human0.73575115
128NCOR1_26117541_ChIP-Seq_K562_Human0.71673420
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.68125716
130BCOR_27268052_Chip-Seq_Bcells_Human0.66827882
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.62269401
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62071559
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61024875
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.60853053
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60851081
136RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60795399
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.59545985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.17416534
2MP0001835_abnormal_antigen_presentation4.06205664
3MP0003436_decreased_susceptibility_to4.02177639
4MP0005058_abnormal_lysosome_morphology3.46228120
5MP0002419_abnormal_innate_immunity3.41373162
6MP0004510_myositis3.30698513
7MP0009785_altered_susceptibility_to3.05458466
8MP0002148_abnormal_hypersensitivity_rea3.04787601
9MP0005000_abnormal_immune_tolerance2.99235628
10MP0003172_abnormal_lysosome_physiology2.98491647
11MP0005025_abnormal_response_to2.90387578
12MP0001790_abnormal_immune_system2.89128510
13MP0005387_immune_system_phenotype2.89128510
14MP0002452_abnormal_antigen_presenting2.67252309
15MP0000685_abnormal_immune_system2.59137832
16MP0006082_CNS_inflammation2.57236267
17MP0003724_increased_susceptibility_to2.54126196
18MP0001800_abnormal_humoral_immune2.48415288
19MP0000569_abnormal_digit_pigmentation2.43989782
20MP0002723_abnormal_immune_serum2.42782861
21MP0009278_abnormal_bone_marrow2.37525678
22MP0003183_abnormal_peptide_metabolism2.37411641
23MP0001819_abnormal_immune_cell2.30168466
24MP0002420_abnormal_adaptive_immunity2.28573684
25MP0005464_abnormal_platelet_physiology2.28550317
26MP0001533_abnormal_skeleton_physiology2.14221628
27MP0005671_abnormal_response_to2.09799094
28MP0002405_respiratory_system_inflammati2.06027920
29MP0009840_abnormal_foam_cell1.99943437
30MP0003191_abnormal_cellular_cholesterol1.99456234
31MP0004947_skin_inflammation1.91847127
32MP0002653_abnormal_ependyma_morphology1.89758478
33MP0001845_abnormal_inflammatory_respons1.84032238
34MP0005174_abnormal_tail_pigmentation1.82610603
35MP0001853_heart_inflammation1.82365900
36MP0003195_calcinosis1.77716885
37MP0003300_gastrointestinal_ulcer1.70899496
38MP0003075_altered_response_to1.68390618
39MP0000716_abnormal_immune_system1.67640867
40MP0005397_hematopoietic_system_phenotyp1.66556571
41MP0001545_abnormal_hematopoietic_system1.66556571
42MP0000343_altered_response_to1.65499696
43MP0003448_altered_tumor_morphology1.63316243
44MP0002398_abnormal_bone_marrow1.57883349
45MP0008469_abnormal_protein_level1.57683912
46MP0005310_abnormal_salivary_gland1.57236214
47MP0001851_eye_inflammation1.51121068
48MP0005076_abnormal_cell_differentiation1.50649739
49MP0010155_abnormal_intestine_physiology1.47761600
50MP0000689_abnormal_spleen_morphology1.41891851
51MP0009333_abnormal_splenocyte_physiolog1.39841026
52MP0002998_abnormal_bone_remodeling1.35696287
53MP0002429_abnormal_blood_cell1.35657971
54MP0002132_abnormal_respiratory_system1.32296127
55MP0009764_decreased_sensitivity_to1.31726277
56MP0000465_gastrointestinal_hemorrhage1.30559325
57MP0004130_abnormal_muscle_cell1.28021930
58MP0002722_abnormal_immune_system1.27022091
59MP0002006_tumorigenesis1.24658664
60MP0002166_altered_tumor_susceptibility1.24516029
61MP0009765_abnormal_xenobiotic_induced1.23283964
62MP0005670_abnormal_white_adipose1.23036170
63MP0003646_muscle_fatigue1.22085301
64MP0000604_amyloidosis1.20844856
65MP0000858_altered_metastatic_potential1.19074277
66MP0003806_abnormal_nucleotide_metabolis1.15687265
67MP0001873_stomach_inflammation1.14542566
68MP0001485_abnormal_pinna_reflex1.12763592
69MP0002933_joint_inflammation1.10859973
70MP0003690_abnormal_glial_cell1.09525170
71MP0003566_abnormal_cell_adhesion1.07163486
72MP0010307_abnormal_tumor_latency1.05959660
73MP0005166_decreased_susceptibility_to1.05858454
74MP0000516_abnormal_urinary_system1.05736950
75MP0005367_renal/urinary_system_phenotyp1.05736950
76MP0003828_pulmonary_edema1.05326712
77MP0008260_abnormal_autophagy1.02942960
78MP0005390_skeleton_phenotype1.01747228
79MP0002396_abnormal_hematopoietic_system1.01537407
80MP0000015_abnormal_ear_pigmentation1.01459622
81MP0004808_abnormal_hematopoietic_stem1.01318684
82MP0002876_abnormal_thyroid_physiology0.95549171
83MP0002139_abnormal_hepatobiliary_system0.95158376
84MP0000371_diluted_coat_color0.91994344
85MP0001986_abnormal_taste_sensitivity0.91705848
86MP0005167_abnormal_blood-brain_barrier0.91397401
87MP0009763_increased_sensitivity_to0.84434613
88MP0000490_abnormal_crypts_of0.83949707
89MP0005075_abnormal_melanosome_morpholog0.81688398
90MP0004782_abnormal_surfactant_physiolog0.80286294
91MP0003866_abnormal_defecation0.80248367
92MP0008877_abnormal_DNA_methylation0.78463325
93MP0002138_abnormal_hepatobiliary_system0.77470594
94MP0002837_dystrophic_cardiac_calcinosis0.75932423
95MP0001663_abnormal_digestive_system0.75204900
96MP0003656_abnormal_erythrocyte_physiolo0.73223701
97MP0003795_abnormal_bone_structure0.71806398
98MP0005164_abnormal_response_to0.71667827
99MP0002277_abnormal_respiratory_mucosa0.71263604
100MP0000249_abnormal_blood_vessel0.71206059
101MP0004381_abnormal_hair_follicle0.69823644
102MP0003011_delayed_dark_adaptation0.69747880
103MP0008872_abnormal_physiological_respon0.69035875
104MP0005084_abnormal_gallbladder_morpholo0.67261154
105MP0005257_abnormal_intraocular_pressure0.67149939
106MP0000703_abnormal_thymus_morphology0.65963101
107MP0001501_abnormal_sleep_pattern0.64043045
108MP0003453_abnormal_keratinocyte_physiol0.62896571
109MP0001958_emphysema0.62017243
110MP0005647_abnormal_sex_gland0.59216309
111MP0008961_abnormal_basal_metabolism0.58009292
112MP0003763_abnormal_thymus_physiology0.54022562
113MP0003091_abnormal_cell_migration0.53927579
114MP0002254_reproductive_system_inflammat0.53891829
115MP0002693_abnormal_pancreas_physiology0.53592659
116MP0009115_abnormal_fat_cell0.53353499
117MP0005334_abnormal_fat_pad0.52419395
118MP0002136_abnormal_kidney_physiology0.51904417
119MP0008004_abnormal_stomach_pH0.50767219
120MP0008873_increased_physiological_sensi0.49775937
121MP0000767_abnormal_smooth_muscle0.46898088
122MP0002928_abnormal_bile_duct0.43691803
123MP0005621_abnormal_cell_physiology0.43334786
124MP0004883_abnormal_blood_vessel0.42682255
125MP0004185_abnormal_adipocyte_glucose0.42518355
126MP0005023_abnormal_wound_healing0.42416210

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.83682708
2Eczematoid dermatitis (HP:0000976)7.15001170
3Recurrent bacterial skin infections (HP:0005406)7.04720907
4Recurrent gram-negative bacterial infections (HP:0005420)6.49101466
5Abnormality of macrophages (HP:0004311)5.21467282
6Vacuolated lymphocytes (HP:0001922)4.78899651
7Mediastinal lymphadenopathy (HP:0100721)4.69962126
8Elevated erythrocyte sedimentation rate (HP:0003565)4.56593747
9Recurrent skin infections (HP:0001581)4.50081056
10Systemic lupus erythematosus (HP:0002725)4.49578171
11Increased cerebral lipofuscin (HP:0011813)4.48429294
12Gingivitis (HP:0000230)4.36873071
13Recurrent fungal infections (HP:0002841)4.22112501
14Obstructive lung disease (HP:0006536)4.15107368
15Chronic obstructive pulmonary disease (HP:0006510)4.15107368
16Myositis (HP:0100614)4.10980105
17Dysostosis multiplex (HP:0000943)3.85400025
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.83958698
19Abnormality of glycolipid metabolism (HP:0010969)3.77678888
20Abnormality of liposaccharide metabolism (HP:0010968)3.77678888
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.77678888
22Orchitis (HP:0100796)3.73219636
23Stomatitis (HP:0010280)3.62743643
24Periodontitis (HP:0000704)3.57408396
25Chronic mucocutaneous candidiasis (HP:0002728)3.46516828
26Recurrent cutaneous fungal infections (HP:0011370)3.46516828
27Autoimmune thrombocytopenia (HP:0001973)3.36263976
28Cellulitis (HP:0100658)3.33802674
29Retrobulbar optic neuritis (HP:0100654)3.27300739
30Optic neuritis (HP:0100653)3.27300739
31Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.23352694
32Short 1st metacarpal (HP:0010034)3.23352694
33Recurrent viral infections (HP:0004429)3.17527640
34Urinary glycosaminoglycan excretion (HP:0003541)3.08635425
35Mucopolysacchariduria (HP:0008155)3.08635425
36Vasculitis (HP:0002633)3.04996559
37Panhypogammaglobulinemia (HP:0003139)3.04965234
38Abnormality of polysaccharide metabolism (HP:0011012)3.01197096
39Abnormality of glycosaminoglycan metabolism (HP:0004371)3.01197096
40Abnormality of mucopolysaccharide metabolism (HP:0011020)3.01197096
41Interstitial pulmonary disease (HP:0006530)2.91806159
42Meningitis (HP:0001287)2.91511345
43Axonal loss (HP:0003447)2.90331559
44Glomerulonephritis (HP:0000099)2.89931206
45Urticaria (HP:0001025)2.89373971
46Pustule (HP:0200039)2.83301794
47Loss of speech (HP:0002371)2.80611718
48Abnormality of the 1st metacarpal (HP:0010009)2.80329803
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.79704452
50Encephalitis (HP:0002383)2.76514132
51Chronic otitis media (HP:0000389)2.73960312
52Keratoconjunctivitis (HP:0001096)2.72339355
53Disinhibition (HP:0000734)2.71134415
54T lymphocytopenia (HP:0005403)2.69381222
55Abnormality of T cell number (HP:0011839)2.68226802
56Abolished electroretinogram (ERG) (HP:0000550)2.65833871
57Stenosis of the external auditory canal (HP:0000402)2.62560662
58Osteomyelitis (HP:0002754)2.57123812
59Leukocytosis (HP:0001974)2.54900741
60Gastrointestinal infarctions (HP:0005244)2.49985170
61Hematochezia (HP:0002573)2.49828144
62Pulmonary infiltrates (HP:0002113)2.47567155
63Spontaneous hematomas (HP:0007420)2.47366183
64Basal ganglia calcification (HP:0002135)2.46901892
65Carpal bone hypoplasia (HP:0001498)2.46890359
66Prostate neoplasm (HP:0100787)2.46090184
67Colitis (HP:0002583)2.44681288
68Petechiae (HP:0000967)2.42822078
69Inflammation of the large intestine (HP:0002037)2.42156544
70Hemoptysis (HP:0002105)2.36354946
71Recurrent pneumonia (HP:0006532)2.36043157
72Abnormality of the pleura (HP:0002103)2.33961121
73Abnormality of B cell number (HP:0010975)2.33216958
74Gingival bleeding (HP:0000225)2.32959711
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32951826
76J-shaped sella turcica (HP:0002680)2.31125521
77IgM deficiency (HP:0002850)2.30813595
78Gastrointestinal inflammation (HP:0004386)2.29919463
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.28820989
80Pendular nystagmus (HP:0012043)2.27674606
81Joint hemorrhage (HP:0005261)2.27583418
82Amyloidosis (HP:0011034)2.26518448
83Pathologic fracture (HP:0002756)2.26163500
84Epistaxis (HP:0000421)2.24568273
85Congenital stationary night blindness (HP:0007642)2.24525018
86Arterial thrombosis (HP:0004420)2.24149853
87Abnormality of eosinophils (HP:0001879)2.22858886
88Prolonged bleeding time (HP:0003010)2.22717759
89Mutism (HP:0002300)2.22114573
90Thick nail (HP:0001805)2.20388213
91Cheilitis (HP:0100825)2.19824837
92Ectopic kidney (HP:0000086)2.19462725
93Thyroiditis (HP:0100646)2.16455054
94Thoracic kyphosis (HP:0002942)2.15527980
95Nasal polyposis (HP:0100582)2.15261716
96Hepatosplenomegaly (HP:0001433)2.12737594
97Granulocytopenia (HP:0001913)2.11650707
98Abnormality of T cells (HP:0002843)2.11548569
99Severe combined immunodeficiency (HP:0004430)2.10440180
100Short phalanx of the thumb (HP:0009660)2.10207573
101Anorexia (HP:0002039)2.09626024
102Recurrent lower respiratory tract infections (HP:0002783)2.09264475
103Bone pain (HP:0002653)2.07033525
104Agnosia (HP:0010524)2.05629051
105Fused cervical vertebrae (HP:0002949)2.05004842
106Abnormality of the nasal mucosa (HP:0000433)2.04424933
107Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03254967
108Absent thumb (HP:0009777)2.03213717
109Nephritis (HP:0000123)2.02064674
110Congenital sensorineural hearing impairment (HP:0008527)2.00819275
111B lymphocytopenia (HP:0010976)1.99694611
112IgG deficiency (HP:0004315)1.97486010
113Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96836644
114Abnormality of the renal collecting system (HP:0004742)1.96145947
115Gangrene (HP:0100758)1.96080235
116Chest pain (HP:0100749)1.95570244
117Deformed sella turcica (HP:0002681)1.95423750
118Agitation (HP:0000713)1.94905606
119Premature loss of primary teeth (HP:0006323)1.94789589
120Myocardial infarction (HP:0001658)1.92720919
121Osteolytic defects of the hand bones (HP:0009699)1.92714135
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.92714135
123Progressive visual loss (HP:0000529)1.91751304
124Combined immunodeficiency (HP:0005387)1.90485941
125Increased IgE level (HP:0003212)1.90271496
126Tetraparesis (HP:0002273)1.89992129
127Stomach cancer (HP:0012126)1.89937994
128Menorrhagia (HP:0000132)1.88801732
129Sepsis (HP:0100806)1.88504553
130Genetic anticipation (HP:0003743)1.88300700
131Hypergammaglobulinemia (HP:0010702)1.88193147
132Albinism (HP:0001022)1.84660226
133Skin ulcer (HP:0200042)1.84083498
134Abnormality of DNA repair (HP:0003254)1.83766080
135Polyneuropathy (HP:0001271)1.83072654
136Keratoconjunctivitis sicca (HP:0001097)1.80084442
137Pulmonary embolism (HP:0002204)1.80031442
138Increased IgM level (HP:0003496)1.79969399
139Pancreatic cysts (HP:0001737)1.79790345
140Porencephaly (HP:0002132)1.79567977
141Duplicated collecting system (HP:0000081)1.79215837
142Hemiplegia (HP:0002301)1.78689500
143Spondylolisthesis (HP:0003302)1.78234202
144Eosinophilia (HP:0001880)1.77783916
145Absent frontal sinuses (HP:0002688)1.77613419
146Episodic fever (HP:0001954)1.77260285
147Abnormality of the thoracic spine (HP:0100711)1.76574599
148Dynein arm defect of respiratory motile cilia (HP:0012255)1.76252007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.18088998
2IRAK44.00667587
3MAP4K13.95296649
4BLK3.63264654
5MAP3K143.23530279
6IRAK33.09703649
7ADRBK23.08990521
8TBK12.95393587
9ERN12.92171717
10TYK22.79540565
11FRK2.63296832
12KIT2.48761113
13ACVR1B2.37791570
14IKBKE2.15172097
15TAOK32.12779268
16FES1.97959711
17GRK11.94953995
18CSK1.84090185
19IKBKB1.80487159
20TLK11.77389561
21SIK21.75733774
22JAK31.75183857
23MAP3K131.74292355
24ZAP701.69715637
25EPHB11.63675356
26FGR1.63564523
27HCK1.55442464
28BTK1.54710666
29JAK11.51468329
30TGFBR21.50299270
31TNK21.49244775
32SYK1.48377801
33CSF1R1.36556038
34TXK1.34033899
35PIM21.31233201
36TRIB31.30548884
37TEC1.24280023
38CAMK1D1.22328640
39BMPR21.21631697
40STK101.18810393
41TTN1.16735969
42RIPK11.16027432
43CHUK1.12228682
44BMPR1B1.11035083
45MAP2K31.09923279
46MATK1.08844397
47LYN1.08066532
48CLK11.08063100
49PINK11.04096969
50LCK1.03686909
51JAK21.02677599
52PIM11.00217404
53CAMK1G0.98363279
54RPS6KA40.96469566
55MAP2K60.94953223
56MAP3K110.92766679
57ABL20.92147843
58MARK30.91376202
59PTK60.90253107
60OXSR10.88676524
61DAPK20.87986577
62BMX0.86975426
63RPS6KA60.84601331
64ZAK0.83195030
65CDC42BPA0.80122024
66GRK60.79237625
67RPS6KC10.78864762
68RPS6KL10.78864762
69MAP3K100.78043695
70MAP4K20.73644118
71PKN20.68935537
72PRKD20.67551770
73MST1R0.66756425
74PRKCQ0.65797957
75CDK120.63722195
76MAP2K40.63538640
77PAK40.62793866
78NUAK10.61596234
79TRPM70.61574265
80EGFR0.59909760
81CAMKK20.59156352
82ADRBK10.58972608
83NME20.58883917
84GRK70.58300487
85RPS6KA20.58031103
86ABL10.57370007
87PRKCD0.57099577
88DYRK30.56729666
89STK110.55942538
90INSRR0.54713058
91MAPK130.54606559
92CDK90.54413826
93LRRK20.54175986
94SIK30.53162608
95WNK30.52685270
96MOS0.52454739
97TGFBR10.51815386
98YES10.51282269
99ITK0.48956185
100DAPK10.48943669
101MAPK40.47784373
102MAP3K10.47708388
103CDK190.46690864
104PIK3CG0.46649426
105FLT30.46623502
106EPHA30.44247657
107WNK40.44104266
108NEK90.43969317
109EIF2AK20.43679816
110MAPKAPK20.43476095
111MAP3K50.42402489
112CDK60.41638687
113DAPK30.40559010
114PTK2B0.40521388
115IRAK20.39983077
116CAMKK10.39396503
117FYN0.39226578
118KSR20.36616137
119IRAK10.35703168
120STK40.34664607
121PRKG20.34256349
122NLK0.33918377
123PDK10.33832664
124PRKAA20.32827528
125HIPK20.32648507
126PDPK10.32628652
127SCYL20.31934714
128PRKCH0.31798850
129MAP2K10.31657969
130MAPK120.30989706
131TAOK20.30361836
132TAOK10.30068436
133PBK0.29222834
134SGK20.28993382
135MAP2K20.28895093
136MAP3K30.28768503
137MAP3K40.27712039
138IGF1R0.27525936

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.51550561
2Staphylococcus aureus infection_Homo sapiens_hsa051503.21286077
3Osteoclast differentiation_Homo sapiens_hsa043802.71752236
4Other glycan degradation_Homo sapiens_hsa005112.51150293
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.48828031
6Lysosome_Homo sapiens_hsa041422.45480601
7Tuberculosis_Homo sapiens_hsa051522.45088671
8Pertussis_Homo sapiens_hsa051332.38617148
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.25581385
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.23980910
11Malaria_Homo sapiens_hsa051442.13618252
12Legionellosis_Homo sapiens_hsa051342.13096304
13B cell receptor signaling pathway_Homo sapiens_hsa046622.12100425
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.11286467
15Phagosome_Homo sapiens_hsa041451.87467840
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85277314
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84501604
18Rheumatoid arthritis_Homo sapiens_hsa053231.81612438
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79513828
20Measles_Homo sapiens_hsa051621.76157907
21Influenza A_Homo sapiens_hsa051641.66765651
22Asthma_Homo sapiens_hsa053101.66189764
23TNF signaling pathway_Homo sapiens_hsa046681.61743853
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.61644898
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57740763
26Salmonella infection_Homo sapiens_hsa051321.57722943
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57430636
28Shigellosis_Homo sapiens_hsa051311.56650447
29Toxoplasmosis_Homo sapiens_hsa051451.54723294
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52135664
31Chemokine signaling pathway_Homo sapiens_hsa040621.51864071
32Graft-versus-host disease_Homo sapiens_hsa053321.48398287
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.40407225
34Antigen processing and presentation_Homo sapiens_hsa046121.38090680
35Apoptosis_Homo sapiens_hsa042101.37323753
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32279587
37Herpes simplex infection_Homo sapiens_hsa051681.28483148
38* Hematopoietic cell lineage_Homo sapiens_hsa046401.22118603
39Acute myeloid leukemia_Homo sapiens_hsa052211.20266016
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.18212069
41Allograft rejection_Homo sapiens_hsa053301.17674932
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11662017
43* Jak-STAT signaling pathway_Homo sapiens_hsa046301.09906966
44Hepatitis B_Homo sapiens_hsa051611.09342538
45African trypanosomiasis_Homo sapiens_hsa051431.08400211
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08203270
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06380782
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00985791
49Hepatitis C_Homo sapiens_hsa051600.99757955
50Chronic myeloid leukemia_Homo sapiens_hsa052200.99324939
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98443027
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95440609
53* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94049648
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.92995021
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92823878
56Ether lipid metabolism_Homo sapiens_hsa005650.92746172
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91094556
58Platelet activation_Homo sapiens_hsa046110.88369508
59Caffeine metabolism_Homo sapiens_hsa002320.88244568
60Amoebiasis_Homo sapiens_hsa051460.87961379
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87761148
62Viral myocarditis_Homo sapiens_hsa054160.83940445
63Type I diabetes mellitus_Homo sapiens_hsa049400.83642138
64Systemic lupus erythematosus_Homo sapiens_hsa053220.82393064
65Primary immunodeficiency_Homo sapiens_hsa053400.82021485
66T cell receptor signaling pathway_Homo sapiens_hsa046600.81068288
67Collecting duct acid secretion_Homo sapiens_hsa049660.79696822
68Pancreatic cancer_Homo sapiens_hsa052120.79316935
69Type II diabetes mellitus_Homo sapiens_hsa049300.74470086
70Tryptophan metabolism_Homo sapiens_hsa003800.72059346
71Complement and coagulation cascades_Homo sapiens_hsa046100.71213214
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69184359
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68975410
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67918450
75Linoleic acid metabolism_Homo sapiens_hsa005910.66531894
76Sulfur metabolism_Homo sapiens_hsa009200.65178511
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64729644
78Prolactin signaling pathway_Homo sapiens_hsa049170.64577498
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64298224
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.61072995
81Epstein-Barr virus infection_Homo sapiens_hsa051690.60776744
82Phototransduction_Homo sapiens_hsa047440.59275567
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.58953411
84VEGF signaling pathway_Homo sapiens_hsa043700.52950552
85Regulation of autophagy_Homo sapiens_hsa041400.51557309
86Endocytosis_Homo sapiens_hsa041440.50056202
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49849346
88Insulin resistance_Homo sapiens_hsa049310.48170832
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45055344
90Notch signaling pathway_Homo sapiens_hsa043300.44776441
91Arachidonic acid metabolism_Homo sapiens_hsa005900.44398556
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44349895
93HIF-1 signaling pathway_Homo sapiens_hsa040660.43758143
94Prion diseases_Homo sapiens_hsa050200.43714367
95Nitrogen metabolism_Homo sapiens_hsa009100.42296440
96Sphingolipid metabolism_Homo sapiens_hsa006000.42255163
97Non-small cell lung cancer_Homo sapiens_hsa052230.41246238
98Morphine addiction_Homo sapiens_hsa050320.41184835
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40858571
100Viral carcinogenesis_Homo sapiens_hsa052030.39108472
101Mineral absorption_Homo sapiens_hsa049780.38751320
102Vibrio cholerae infection_Homo sapiens_hsa051100.36835172
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35670410
104Renin-angiotensin system_Homo sapiens_hsa046140.32828200
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31865966
106Small cell lung cancer_Homo sapiens_hsa052220.31803182
107Proteoglycans in cancer_Homo sapiens_hsa052050.31018137
108HTLV-I infection_Homo sapiens_hsa051660.30870557
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29100435
110Glycerolipid metabolism_Homo sapiens_hsa005610.28408696
111ABC transporters_Homo sapiens_hsa020100.27168202
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.27084562
113Oxidative phosphorylation_Homo sapiens_hsa001900.27029725
114Dorso-ventral axis formation_Homo sapiens_hsa043200.26625289
115Autoimmune thyroid disease_Homo sapiens_hsa053200.26609995
116Colorectal cancer_Homo sapiens_hsa052100.26262860
117PPAR signaling pathway_Homo sapiens_hsa033200.25534776
118Renal cell carcinoma_Homo sapiens_hsa052110.24873147
119Ovarian steroidogenesis_Homo sapiens_hsa049130.24729646
120FoxO signaling pathway_Homo sapiens_hsa040680.24233529
121MAPK signaling pathway_Homo sapiens_hsa040100.23741472
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22398027
123mTOR signaling pathway_Homo sapiens_hsa041500.18022428
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.17593799
125Chemical carcinogenesis_Homo sapiens_hsa052040.17254447
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16726376
127Olfactory transduction_Homo sapiens_hsa047400.14900296
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.13687177

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