CSF2RB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)5.69706728
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.69706728
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.69706728
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.69706728
5modulation by symbiont of host immune response (GO:0052553)5.69706728
6positive regulation by symbiont of host defense response (GO:0052509)5.69706728
7neutrophil activation involved in immune response (GO:0002283)5.68965219
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.32923914
9detection of other organism (GO:0098543)5.13766845
10response to peptidoglycan (GO:0032494)4.92360269
11detection of molecule of bacterial origin (GO:0032490)4.81691104
12detection of bacterium (GO:0016045)4.79523824
13production of molecular mediator involved in inflammatory response (GO:0002532)4.75275120
14respiratory burst (GO:0045730)4.74050016
15detection of external biotic stimulus (GO:0098581)4.58173308
16immunoglobulin mediated immune response (GO:0016064)4.56730782
17granulocyte activation (GO:0036230)4.34794220
18neutrophil activation (GO:0042119)4.30688530
19regulation of gamma-delta T cell activation (GO:0046643)4.27213532
20positive regulation of mast cell degranulation (GO:0043306)4.27066153
21positive regulation of mast cell activation involved in immune response (GO:0033008)4.27066153
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.21176779
23macrophage activation involved in immune response (GO:0002281)4.17907394
24positive regulation of interferon-alpha production (GO:0032727)4.15466989
25regulation of interferon-beta biosynthetic process (GO:0045357)4.14662458
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.08601346
27response to interleukin-15 (GO:0070672)4.08500295
28positive regulation of mast cell activation (GO:0033005)4.07206313
29leukocyte migration involved in inflammatory response (GO:0002523)4.07152613
30detection of biotic stimulus (GO:0009595)3.99764232
31cellular extravasation (GO:0045123)3.93016465
32regulation of interferon-alpha production (GO:0032647)3.91798936
33positive regulation of antigen processing and presentation (GO:0002579)3.85859909
34regulation of mast cell degranulation (GO:0043304)3.84481760
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.81800386
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.80604093
37response to host immune response (GO:0052572)3.80604093
38antigen processing and presentation of endogenous antigen (GO:0019883)3.76957493
39negative regulation of leukocyte mediated immunity (GO:0002704)3.71439385
40regulation of gamma-delta T cell differentiation (GO:0045586)3.70193629
41hydrogen peroxide biosynthetic process (GO:0050665)3.69019480
42cellular response to interleukin-15 (GO:0071350)3.68854636
43negative regulation of T cell mediated immunity (GO:0002710)3.68283688
44positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.67939156
45regulation of hypersensitivity (GO:0002883)3.65421226
46response to muramyl dipeptide (GO:0032495)3.62853900
47myeloid cell activation involved in immune response (GO:0002275)3.59182411
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.59025403
49myeloid dendritic cell differentiation (GO:0043011)3.57357109
50regulation of mast cell activation involved in immune response (GO:0033006)3.55521333
51superoxide anion generation (GO:0042554)3.51202158
52positive regulation of leukocyte degranulation (GO:0043302)3.50599592
53regulation of T cell tolerance induction (GO:0002664)3.50525163
54B cell mediated immunity (GO:0019724)3.49772432
55germinal center formation (GO:0002467)3.49635759
56positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.48895331
57reactive oxygen species biosynthetic process (GO:1903409)3.45740489
58B cell receptor signaling pathway (GO:0050853)3.44925012
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.44558819
60regulation of mast cell activation (GO:0033003)3.43982179
61positive regulation of gamma-delta T cell activation (GO:0046645)3.43669841
62regulation of tolerance induction (GO:0002643)3.42165655
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.41337979
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41337979
65positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.39736024
66myeloid dendritic cell activation (GO:0001773)3.38839805
67positive regulation of B cell differentiation (GO:0045579)3.37559008
68negative regulation of erythrocyte differentiation (GO:0045647)3.34821830
69antigen processing and presentation via MHC class Ib (GO:0002475)3.33056656
70response to host (GO:0075136)3.32161402
71response to host defenses (GO:0052200)3.32161402
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32161402
73natural killer cell mediated immunity (GO:0002228)3.31564765
74natural killer cell mediated cytotoxicity (GO:0042267)3.31564765
75positive regulation of chemokine biosynthetic process (GO:0045080)3.31444781
76leukocyte aggregation (GO:0070486)3.29672210
77regulation of antigen processing and presentation (GO:0002577)3.29600307
78neutrophil mediated immunity (GO:0002446)3.27835575
79regulation of leukocyte degranulation (GO:0043300)3.26743462
80positive regulation of cellular amide metabolic process (GO:0034250)3.26151063
81leukocyte mediated cytotoxicity (GO:0001909)3.21132041
82regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20770321
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.20578956
84dendritic cell differentiation (GO:0097028)3.20447127
85positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.18065259
86regulation of B cell receptor signaling pathway (GO:0050855)3.15090222
87dendritic cell chemotaxis (GO:0002407)3.14948658
88defense response to protozoan (GO:0042832)3.14786343
89positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.14640842
90regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13611158
91Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12847432
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.12788465
93dendritic cell migration (GO:0036336)3.12047647
94interferon-gamma-mediated signaling pathway (GO:0060333)3.11066425
95leukocyte degranulation (GO:0043299)3.11023537
96cellular response to zinc ion (GO:0071294)3.10425572
97regulation of T-helper 2 cell differentiation (GO:0045628)3.10032890
98myeloid leukocyte mediated immunity (GO:0002444)3.09658152
99response to type I interferon (GO:0034340)3.09022326
100negative regulation of interleukin-17 production (GO:0032700)3.08600532
101positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.06989982
102cellular response to type I interferon (GO:0071357)3.06139654
103type I interferon signaling pathway (GO:0060337)3.06139654
104regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03891020
105negative thymic T cell selection (GO:0045060)3.02461315
106regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.01767683
107regulation of interleukin-12 biosynthetic process (GO:0045075)3.00224898
108regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00037427
109positive regulation of interferon-beta production (GO:0032728)2.99884715
110T-helper 1 type immune response (GO:0042088)2.97495590
111JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.97193490
112myeloid leukocyte activation (GO:0002274)2.96874822
113positive regulation of interleukin-12 production (GO:0032735)2.96366634
114NIK/NF-kappaB signaling (GO:0038061)2.96288462
115negative regulation of type 2 immune response (GO:0002829)2.96125841
116regulation of T cell mediated cytotoxicity (GO:0001914)2.95735820
117macrophage activation (GO:0042116)2.95363707
118regulation of B cell differentiation (GO:0045577)2.93401482
119negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92062585
120negative regulation of T-helper cell differentiation (GO:0045623)2.92062585
121negative T cell selection (GO:0043383)2.91530802
122microglial cell activation (GO:0001774)2.91366796
123regulation of T-helper 1 cell differentiation (GO:0045625)2.91043921
124regulation of mononuclear cell migration (GO:0071675)2.90831210
125positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.90408874
126response to protozoan (GO:0001562)2.89274141
127positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88978832
128leukotriene metabolic process (GO:0006691)2.88416102
129regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.88405173
130T cell migration (GO:0072678)2.88051450
131negative regulation of cell killing (GO:0031342)2.86163143
132negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86163143
133regulation of cholesterol storage (GO:0010885)2.85359550
134regulation of chemokine biosynthetic process (GO:0045073)2.85192818
135negative regulation of interleukin-12 production (GO:0032695)2.83953426
136positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.83059102
137neutrophil chemotaxis (GO:0030593)2.82311681
138positive regulation of monocyte chemotaxis (GO:0090026)2.81762563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.34402641
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.21073354
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.32604533
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.14485102
5* BP1_19119308_ChIP-ChIP_Hs578T_Human4.02690683
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.93001108
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.81922894
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.78452785
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.48884963
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.35684147
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.34361732
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.21925612
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15096804
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94085918
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93820532
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71684910
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.69993030
18SCL_19346495_ChIP-Seq_HPC-7_Human2.51473085
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.51288549
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.51249701
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50461733
22* SPI1_23547873_ChIP-Seq_NB4_Human2.42422821
23GATA1_22025678_ChIP-Seq_K562_Human2.36897007
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32362646
25* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17403397
26VDR_24763502_ChIP-Seq_THP-1_Human2.11555594
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11184910
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.10261205
29VDR_21846776_ChIP-Seq_THP-1_Human2.03371252
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01894630
31MAF_26560356_Chip-Seq_TH1_Human1.93480748
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.91219234
33MYB_26560356_Chip-Seq_TH2_Human1.90942059
34SPI1_23127762_ChIP-Seq_K562_Human1.88333633
35* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78870655
36RUNX_20019798_ChIP-Seq_JUKART_Human1.76596591
37PU_27001747_Chip-Seq_BMDM_Mouse1.75335178
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67390483
39* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67337027
40* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66108807
41* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64636421
42* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63444833
43* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62412617
44VDR_24787735_ChIP-Seq_THP-1_Human1.60728191
45MYB_26560356_Chip-Seq_TH1_Human1.57266415
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55540170
47* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54060645
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.50766429
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47631890
50TCF7_22412390_ChIP-Seq_EML_Mouse1.45257969
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45059985
52* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44368139
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41082853
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41061176
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38471281
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37961442
57* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35139783
58* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34654359
59UTX_26944678_Chip-Seq_JUKART_Human1.32724673
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30966078
61* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29877151
62GATA3_27048872_Chip-Seq_THYMUS_Human1.27069920
63MYC_22102868_ChIP-Seq_BL_Human1.26544122
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25409987
65* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24766616
66* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23870763
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.22254007
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21229242
69TFEB_21752829_ChIP-Seq_HELA_Human1.17115445
70* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17056416
71LXR_22292898_ChIP-Seq_THP-1_Human1.15856278
72E2F7_22180533_ChIP-Seq_HELA_Human1.15850523
73GATA1_19941826_ChIP-Seq_K562_Human1.15655423
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.15496147
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14779198
76* GATA3_26560356_Chip-Seq_TH2_Human1.14248966
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13824968
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.13385010
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08981532
80MAF_26560356_Chip-Seq_TH2_Human1.07332998
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02203487
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00584142
83GATA2_19941826_ChIP-Seq_K562_Human0.99007561
84* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97799472
85BCL6_27268052_Chip-Seq_Bcells_Human0.96695805
86KDM2B_26808549_Chip-Seq_DND41_Human0.95341651
87IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94205849
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92589592
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92177681
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91189845
91BCOR_27268052_Chip-Seq_Bcells_Human0.90486368
92KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89517646
93HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89485708
94* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88736475
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87693554
96* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85572065
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85395344
98KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84487021
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83623951
100NCOR1_26117541_ChIP-Seq_K562_Human0.82072511
101GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80439124
102EGR1_19032775_ChIP-ChIP_M12_Human0.80130467
103SPI1_20517297_ChIP-Seq_HL60_Human0.76492597
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75990364
105* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75384904
106* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73427092
107ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69451461
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64956835
109* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62925434
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.62208924
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.61499490
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61444294
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.60796327
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.60796327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.62678698
2MP0003303_peritoneal_inflammation4.00914465
3MP0003436_decreased_susceptibility_to3.95926241
4MP0009785_altered_susceptibility_to3.39097877
5* MP0002148_abnormal_hypersensitivity_rea3.37819357
6MP0002419_abnormal_innate_immunity3.27075299
7MP0005000_abnormal_immune_tolerance3.11550648
8* MP0005025_abnormal_response_to2.88854839
9MP0006082_CNS_inflammation2.86005208
10MP0001790_abnormal_immune_system2.84376633
11MP0005387_immune_system_phenotype2.84376633
12MP0005058_abnormal_lysosome_morphology2.72354844
13MP0004510_myositis2.71449648
14MP0000685_abnormal_immune_system2.66628764
15* MP0002452_abnormal_antigen_presenting2.65777157
16MP0005671_abnormal_response_to2.60972270
17MP0005464_abnormal_platelet_physiology2.49434659
18* MP0001800_abnormal_humoral_immune2.48841698
19* MP0002723_abnormal_immune_serum2.47436402
20MP0003724_increased_susceptibility_to2.43982893
21* MP0001819_abnormal_immune_cell2.32360995
22* MP0002420_abnormal_adaptive_immunity2.29755751
23MP0005310_abnormal_salivary_gland2.11486869
24MP0001533_abnormal_skeleton_physiology1.99633500
25MP0001853_heart_inflammation1.98286932
26* MP0002405_respiratory_system_inflammati1.97127153
27MP0003172_abnormal_lysosome_physiology1.90313007
28MP0001845_abnormal_inflammatory_respons1.86200415
29MP0003300_gastrointestinal_ulcer1.82055946
30MP0005451_abnormal_body_composition1.82022171
31MP0004947_skin_inflammation1.81389093
32MP0009764_decreased_sensitivity_to1.81215526
33MP0003191_abnormal_cellular_cholesterol1.75435826
34MP0005397_hematopoietic_system_phenotyp1.72909651
35MP0001545_abnormal_hematopoietic_system1.72909651
36MP0003448_altered_tumor_morphology1.72648822
37MP0002398_abnormal_bone_marrow1.72395347
38* MP0000716_abnormal_immune_system1.69698121
39MP0002138_abnormal_hepatobiliary_system1.67598226
40MP0010155_abnormal_intestine_physiology1.66698552
41MP0009278_abnormal_bone_marrow1.66615661
42MP0008469_abnormal_protein_level1.61269392
43MP0000343_altered_response_to1.60794708
44MP0009333_abnormal_splenocyte_physiolog1.53244997
45MP0002006_tumorigenesis1.52610350
46MP0010307_abnormal_tumor_latency1.45822233
47MP0003075_altered_response_to1.45679443
48MP0000858_altered_metastatic_potential1.42129814
49* MP0002429_abnormal_blood_cell1.41876231
50MP0003656_abnormal_erythrocyte_physiolo1.41734931
51MP0009840_abnormal_foam_cell1.40489924
52MP0000689_abnormal_spleen_morphology1.39889934
53MP0000569_abnormal_digit_pigmentation1.38494460
54* MP0002722_abnormal_immune_system1.33627195
55MP0004381_abnormal_hair_follicle1.30078504
56MP0002998_abnormal_bone_remodeling1.27600606
57MP0002166_altered_tumor_susceptibility1.26058401
58MP0002254_reproductive_system_inflammat1.25641299
59MP0001851_eye_inflammation1.23424183
60MP0000465_gastrointestinal_hemorrhage1.21810151
61MP0000604_amyloidosis1.20810867
62MP0004808_abnormal_hematopoietic_stem1.18142945
63MP0005166_decreased_susceptibility_to1.17853468
64MP0005174_abnormal_tail_pigmentation1.16569178
65MP0003828_pulmonary_edema1.10418950
66MP0003566_abnormal_cell_adhesion1.04631453
67MP0010352_gastrointestinal_tract_polyps1.03589118
68MP0005076_abnormal_cell_differentiation1.02013340
69MP0009763_increased_sensitivity_to1.00268161
70MP0003183_abnormal_peptide_metabolism0.99727023
71MP0003690_abnormal_glial_cell0.95556366
72MP0008004_abnormal_stomach_pH0.94870335
73MP0003186_abnormal_redox_activity0.92643400
74MP0000490_abnormal_crypts_of0.92306718
75MP0002877_abnormal_melanocyte_morpholog0.91965621
76MP0005390_skeleton_phenotype0.87669667
77MP0001873_stomach_inflammation0.87518680
78MP0005164_abnormal_response_to0.87118384
79MP0004782_abnormal_surfactant_physiolog0.86863287
80MP0002277_abnormal_respiratory_mucosa0.85644655
81MP0002396_abnormal_hematopoietic_system0.85446714
82MP0005167_abnormal_blood-brain_barrier0.84380418
83MP0003763_abnormal_thymus_physiology0.81159596
84MP0008260_abnormal_autophagy0.80849032
85MP0003453_abnormal_keratinocyte_physiol0.80503929
86MP0002933_joint_inflammation0.79659011
87MP0003866_abnormal_defecation0.77324076
88MP0003045_fibrosis0.77000439
89MP0003221_abnormal_cardiomyocyte_apopto0.76476811
90MP0005257_abnormal_intraocular_pressure0.74081780
91MP0000371_diluted_coat_color0.73727180
92MP0000249_abnormal_blood_vessel0.73657011
93MP0001348_abnormal_lacrimal_gland0.69699369
94MP0005075_abnormal_melanosome_morpholog0.69479543
95MP0008874_decreased_physiological_sensi0.67731564
96MP0000703_abnormal_thymus_morphology0.67044826
97MP0003795_abnormal_bone_structure0.66035530
98MP0000015_abnormal_ear_pigmentation0.65438609
99MP0001663_abnormal_digestive_system0.63959762
100MP0003806_abnormal_nucleotide_metabolis0.62000042
101MP0002332_abnormal_exercise_endurance0.59312725
102MP0002132_abnormal_respiratory_system0.59252080
103MP0008873_increased_physiological_sensi0.58441931
104MP0009765_abnormal_xenobiotic_induced0.58389266
105MP0004130_abnormal_muscle_cell0.54779701
106MP0001986_abnormal_taste_sensitivity0.53911710
107MP0002136_abnormal_kidney_physiology0.53692832
108MP0002133_abnormal_respiratory_system0.52909039
109MP0005388_respiratory_system_phenotype0.52909039
110MP0004883_abnormal_blood_vessel0.52335677
111MP0005319_abnormal_enzyme/_coenzyme0.51951340
112MP0002019_abnormal_tumor_incidence0.51897931
113MP0003091_abnormal_cell_migration0.51873865
114MP0000920_abnormal_myelination0.50494710
115MP0001958_emphysema0.48543634
116MP0000609_abnormal_liver_physiology0.47972235

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.52608812
2Eczematoid dermatitis (HP:0000976)7.19127062
3Recurrent bacterial skin infections (HP:0005406)7.03910380
4Recurrent gram-negative bacterial infections (HP:0005420)6.30115320
5Abnormality of macrophages (HP:0004311)5.24911445
6Mediastinal lymphadenopathy (HP:0100721)4.93155948
7Recurrent skin infections (HP:0001581)4.48866345
8Vacuolated lymphocytes (HP:0001922)4.44143948
9Recurrent fungal infections (HP:0002841)4.32689504
10Obstructive lung disease (HP:0006536)4.25424027
11Chronic obstructive pulmonary disease (HP:0006510)4.25424027
12Petechiae (HP:0000967)4.24837387
13Gingivitis (HP:0000230)4.14557068
14Increased cerebral lipofuscin (HP:0011813)4.13390852
15Myositis (HP:0100614)3.87481397
16Elevated erythrocyte sedimentation rate (HP:0003565)3.78627614
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.75325400
18Encephalitis (HP:0002383)3.74222486
19Autoimmune thrombocytopenia (HP:0001973)3.69693748
20Stomatitis (HP:0010280)3.62111180
21Cellulitis (HP:0100658)3.61696769
22Orchitis (HP:0100796)3.59498923
23Systemic lupus erythematosus (HP:0002725)3.59271858
24Recurrent viral infections (HP:0004429)3.51441734
25Optic neuritis (HP:0100653)3.38051797
26Retrobulbar optic neuritis (HP:0100654)3.38051797
27Chronic mucocutaneous candidiasis (HP:0002728)3.35285494
28Recurrent cutaneous fungal infections (HP:0011370)3.35285494
29Vasculitis (HP:0002633)3.25698201
30Tetraparesis (HP:0002273)3.15134433
31Urticaria (HP:0001025)3.12341603
32Periodontitis (HP:0000704)3.10508757
33T lymphocytopenia (HP:0005403)3.07363271
34Axonal loss (HP:0003447)3.04638204
35Hypochromic microcytic anemia (HP:0004840)3.00493533
36Peritonitis (HP:0002586)2.98851589
37Abnormality of T cell number (HP:0011839)2.98051221
38Episodic fever (HP:0001954)2.96714151
39Meningitis (HP:0001287)2.95966772
40Interstitial pulmonary disease (HP:0006530)2.95828989
41Chronic otitis media (HP:0000389)2.94110596
42Disinhibition (HP:0000734)2.93730821
43Gingival bleeding (HP:0000225)2.93703392
44Abnormality of liposaccharide metabolism (HP:0010968)2.91294190
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.91294190
46Abnormality of glycolipid metabolism (HP:0010969)2.91294190
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.90311520
48Pustule (HP:0200039)2.88240800
49Dysostosis multiplex (HP:0000943)2.87358812
50Prostate neoplasm (HP:0100787)2.86749523
51Prolonged bleeding time (HP:0003010)2.82605859
52Hypochromic anemia (HP:0001931)2.79975182
53Pulmonary embolism (HP:0002204)2.72802795
54Leukocytosis (HP:0001974)2.72713564
55Anorexia (HP:0002039)2.71832287
56Myocardial infarction (HP:0001658)2.70378405
57Amyloidosis (HP:0011034)2.68724059
58Basal ganglia calcification (HP:0002135)2.68414826
59Osteomyelitis (HP:0002754)2.66882589
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61884886
61Pulmonary infiltrates (HP:0002113)2.61192213
62Increased IgM level (HP:0003496)2.60592164
63Abnormality of T cells (HP:0002843)2.56549487
64Spontaneous hematomas (HP:0007420)2.55804766
65Panhypogammaglobulinemia (HP:0003139)2.52734697
66Epistaxis (HP:0000421)2.52703343
67Arterial thrombosis (HP:0004420)2.51375016
68Recurrent pneumonia (HP:0006532)2.49790439
69Thick nail (HP:0001805)2.49046268
70Purpura (HP:0000979)2.47531340
71Gastrointestinal infarctions (HP:0005244)2.47372065
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.45267648
73Gangrene (HP:0100758)2.42877025
74Granulocytopenia (HP:0001913)2.42534990
75Abnormality of the peritoneum (HP:0002585)2.41312575
76Impaired platelet aggregation (HP:0003540)2.39635258
77Abnormal platelet function (HP:0011869)2.39635258
78Abnormality of the pleura (HP:0002103)2.39515065
79Urinary glycosaminoglycan excretion (HP:0003541)2.39353452
80Mucopolysacchariduria (HP:0008155)2.39353452
81Agnosia (HP:0010524)2.36329853
82Hemoptysis (HP:0002105)2.35130897
83Loss of speech (HP:0002371)2.26490338
84Glomerulonephritis (HP:0000099)2.26295659
85Hypergammaglobulinemia (HP:0010702)2.24820786
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.23829016
87Abnormality of polysaccharide metabolism (HP:0011012)2.23829016
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.23829016
89Microcytic anemia (HP:0001935)2.23484464
90Abnormal delayed hypersensitivity skin test (HP:0002963)2.22336709
91Recurrent lower respiratory tract infections (HP:0002783)2.21206218
92Abnormality of the endocardium (HP:0004306)2.20214674
93Hematochezia (HP:0002573)2.19904971
94Lymphopenia (HP:0001888)2.18100693
95Abnormality of T cell physiology (HP:0011840)2.17939650
96Thrombocytosis (HP:0001894)2.17731153
97Bilateral sensorineural hearing impairment (HP:0008619)2.16554413
98Glomerulopathy (HP:0100820)2.13960438
99Joint hemorrhage (HP:0005261)2.12629687
100Viral hepatitis (HP:0006562)2.12460949
101Premature loss of primary teeth (HP:0006323)2.11771094
102Inflammation of the large intestine (HP:0002037)2.10646195
103Abnormality of cells of the lymphoid lineage (HP:0012140)2.10304950
104Abnormality of the prostate (HP:0008775)2.10095101
105Increased IgE level (HP:0003212)2.08385095
106Abnormal platelet volume (HP:0011876)2.08015880
107Slow saccadic eye movements (HP:0000514)2.07832334
108Sepsis (HP:0100806)2.07716009
109Vertigo (HP:0002321)2.07235456
110Hepatosplenomegaly (HP:0001433)2.06978730
111Colitis (HP:0002583)2.06520030
112Nasal polyposis (HP:0100582)2.05874358
113Chest pain (HP:0100749)2.04369237
114Keratoconjunctivitis sicca (HP:0001097)2.02514875
115Menorrhagia (HP:0000132)2.01925308
116Keratitis (HP:0000491)1.98907150
117Acne (HP:0001061)1.98450852
118Osteolytic defects of the hand bones (HP:0009699)1.96871830
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.96871830
120IgM deficiency (HP:0002850)1.96860289
121Gastrointestinal inflammation (HP:0004386)1.96344484
122Agammaglobulinemia (HP:0004432)1.95926055
123Eosinophilia (HP:0001880)1.95618311
124Acute hepatic failure (HP:0006554)1.95371759
125Segmental peripheral demyelination/remyelination (HP:0003481)1.93815240
126Bone pain (HP:0002653)1.91536134
127Increased serum ferritin (HP:0003281)1.90757541
128Keratoconjunctivitis (HP:0001096)1.90112207
129Polycythemia (HP:0001901)1.89925099
130Skin rash (HP:0000988)1.89301542
131Recurrent bronchitis (HP:0002837)1.88962862
132Abnormality of the nasal mucosa (HP:0000433)1.88918602
133Skin ulcer (HP:0200042)1.88829662
134Poor head control (HP:0002421)1.88749476
135Albinism (HP:0001022)1.88274326
136Subacute progressive viral hepatitis (HP:0006572)1.87731408
137Abnormality of the pericardium (HP:0001697)1.87721876
138J-shaped sella turcica (HP:0002680)1.87083259
139Cheilitis (HP:0100825)1.86233111
140Polyneuropathy (HP:0001271)1.85544065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.54077730
2BLK3.96618483
3MAP3K143.84614575
4MAP4K13.22600442
5TBK13.20392151
6IRAK43.20285401
7TYK22.96306006
8IRAK32.90312410
9PIM22.66722422
10IKBKB2.46933634
11PRPF4B2.44338864
12TAOK32.40925125
13KIT2.20501886
14JAK32.19944981
15IKBKE2.18851448
16TNK22.01413626
17PBK1.97828851
18ERN11.93424835
19JAK11.76019265
20TAOK11.74312932
21SYK1.65144600
22TXK1.59730166
23NEK91.56561070
24BTK1.55482788
25ZAP701.53196294
26PIM11.51559856
27CHUK1.51538264
28EPHB11.49737849
29CSK1.46271357
30BMX1.44366261
31HCK1.37851232
32KSR21.34136243
33MAP3K131.33839041
34CSF1R1.33117984
35TRIB31.27992301
36FES1.27479923
37TEC1.22910245
38STK41.17261713
39RPS6KA41.12351091
40STK101.11989990
41* LYN1.04853891
42FGR1.04364491
43NME21.02922501
44CLK11.02920446
45MATK1.01964680
46LCK1.01802389
47MAP2K31.01132132
48ABL21.01005692
49MARK20.98967891
50IRAK20.97675267
51TGFBR20.92375915
52* JAK20.91891157
53TAOK20.89765240
54MST40.88607353
55CDK60.85359666
56MAP3K110.84345429
57TRPM70.83049703
58MAP3K60.82450833
59EIF2AK10.81757236
60MARK30.80167175
61LRRK20.78888303
62SMG10.78396833
63YES10.77652524
64PRKD20.77499662
65PKN20.76229248
66FGFR30.76073374
67MAP3K20.74013818
68SCYL20.71591211
69CDC42BPA0.71082695
70BMPR20.69636400
71TESK20.68479034
72SIK20.67077934
73CDK190.66984842
74ABL10.65592923
75ITK0.64123194
76FYN0.63966019
77PRKCD0.63095081
78MAP3K50.62897613
79MAP3K70.61753892
80MAP2K40.61235641
81PTK60.60348299
82EGFR0.59639582
83PTK2B0.58531915
84MAPK120.58414192
85GRK60.55626695
86SGK30.55255891
87HIPK20.54398534
88MAPKAPK20.54295207
89RAF10.53348923
90STK30.52281116
91STK110.51740601
92RPS6KA60.51653176
93EPHA30.51044983
94RIPK10.50700734
95FLT30.50273593
96MAPK70.50058931
97DYRK1B0.49079974
98SIK30.48920705
99DAPK20.47506770
100MAP3K100.47454274
101FGFR40.46742250
102RET0.45924537
103PRKCQ0.45576898
104TESK10.45382165
105ALK0.44072666
106PIK3CG0.43604818
107KSR10.42671685
108EIF2AK20.42326783
109NLK0.41557016
110RPS6KA20.41192030
111CDK120.41084504
112GRK70.40532002
113MAP2K60.37895438
114RPS6KC10.37559866
115RPS6KL10.37559866
116CAMK1D0.37106130
117IRAK10.36792063
118SGK20.36652863
119PRKG20.34894047
120CAMKK10.33802340
121MST1R0.33653554
122SIK10.33099615
123WNK10.33027682
124MAP3K10.32628268
125PDK10.32061259
126PDPK10.31271446
127STK240.31028691
128STK380.31022888
129MAP3K30.30498734
130PAK40.29909068
131CAMKK20.29301126
132MAP3K120.29069085
133TTN0.29039325
134DAPK30.28669405
135KDR0.27380443
136RPS6KA10.27149480

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.60395622
2Staphylococcus aureus infection_Homo sapiens_hsa051502.74080376
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.68539885
4Graft-versus-host disease_Homo sapiens_hsa053322.67221228
5Osteoclast differentiation_Homo sapiens_hsa043802.57046602
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.47573200
7Legionellosis_Homo sapiens_hsa051342.47380267
8Asthma_Homo sapiens_hsa053102.41994066
9Tuberculosis_Homo sapiens_hsa051522.37297372
10Pertussis_Homo sapiens_hsa051332.25554924
11Allograft rejection_Homo sapiens_hsa053302.21710271
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19267968
13Malaria_Homo sapiens_hsa051442.15361633
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10990977
15Measles_Homo sapiens_hsa051622.06813401
16Lysosome_Homo sapiens_hsa041422.02582595
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95331584
18Rheumatoid arthritis_Homo sapiens_hsa053231.92031898
19B cell receptor signaling pathway_Homo sapiens_hsa046621.90377985
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.84449408
21Phagosome_Homo sapiens_hsa041451.84186393
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81843523
23Toxoplasmosis_Homo sapiens_hsa051451.78636038
24Influenza A_Homo sapiens_hsa051641.73231556
25TNF signaling pathway_Homo sapiens_hsa046681.72194250
26Hematopoietic cell lineage_Homo sapiens_hsa046401.68602504
27Salmonella infection_Homo sapiens_hsa051321.66412151
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63449734
29Chemokine signaling pathway_Homo sapiens_hsa040621.53317525
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52139687
31Other glycan degradation_Homo sapiens_hsa005111.51695547
32Type I diabetes mellitus_Homo sapiens_hsa049401.50330437
33Herpes simplex infection_Homo sapiens_hsa051681.46795658
34* Apoptosis_Homo sapiens_hsa042101.45358750
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.43845992
36Shigellosis_Homo sapiens_hsa051311.41701408
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38994891
38* Jak-STAT signaling pathway_Homo sapiens_hsa046301.37533236
39Antigen processing and presentation_Homo sapiens_hsa046121.35942864
40African trypanosomiasis_Homo sapiens_hsa051431.34232021
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30689277
42Hepatitis B_Homo sapiens_hsa051611.20298668
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18815385
44* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18076705
45Viral myocarditis_Homo sapiens_hsa054161.10985806
46Acute myeloid leukemia_Homo sapiens_hsa052211.09546845
47Primary immunodeficiency_Homo sapiens_hsa053401.09211783
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07902640
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.02169599
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99753398
51Autoimmune thyroid disease_Homo sapiens_hsa053200.97457982
52Chronic myeloid leukemia_Homo sapiens_hsa052200.97046149
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95832029
54Hepatitis C_Homo sapiens_hsa051600.93855732
55Platelet activation_Homo sapiens_hsa046110.90946121
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89245098
57Amoebiasis_Homo sapiens_hsa051460.89018721
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86374732
59Renin-angiotensin system_Homo sapiens_hsa046140.84452949
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80789156
61T cell receptor signaling pathway_Homo sapiens_hsa046600.78158782
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.77398456
63Prolactin signaling pathway_Homo sapiens_hsa049170.77322351
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76768468
65Pancreatic cancer_Homo sapiens_hsa052120.75506680
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.66969301
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.65791733
68Dorso-ventral axis formation_Homo sapiens_hsa043200.65236827
69Epstein-Barr virus infection_Homo sapiens_hsa051690.64249227
70Endometrial cancer_Homo sapiens_hsa052130.62596752
71Complement and coagulation cascades_Homo sapiens_hsa046100.62044569
72Collecting duct acid secretion_Homo sapiens_hsa049660.60794149
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.57520175
74GnRH signaling pathway_Homo sapiens_hsa049120.57247921
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55573233
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55033168
77HIF-1 signaling pathway_Homo sapiens_hsa040660.53953994
78Choline metabolism in cancer_Homo sapiens_hsa052310.53817047
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53750562
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51098490
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50303770
82Viral carcinogenesis_Homo sapiens_hsa052030.49808264
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48109696
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47804056
85Inositol phosphate metabolism_Homo sapiens_hsa005620.47281204
86Small cell lung cancer_Homo sapiens_hsa052220.46912536
87Colorectal cancer_Homo sapiens_hsa052100.46865967
88VEGF signaling pathway_Homo sapiens_hsa043700.45049687
89Rap1 signaling pathway_Homo sapiens_hsa040150.43260883
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43020535
91Prion diseases_Homo sapiens_hsa050200.42379716
92MAPK signaling pathway_Homo sapiens_hsa040100.41794408
93Endocytosis_Homo sapiens_hsa041440.41541607
94ErbB signaling pathway_Homo sapiens_hsa040120.41521874
95Type II diabetes mellitus_Homo sapiens_hsa049300.40831331
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40323827
97Insulin resistance_Homo sapiens_hsa049310.37933572
98Regulation of autophagy_Homo sapiens_hsa041400.36785080
99Non-small cell lung cancer_Homo sapiens_hsa052230.36565165
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.36511267
101Prostate cancer_Homo sapiens_hsa052150.36502709
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35152307
103HTLV-I infection_Homo sapiens_hsa051660.29283542
104Proteoglycans in cancer_Homo sapiens_hsa052050.27831057
105p53 signaling pathway_Homo sapiens_hsa041150.25277455
106FoxO signaling pathway_Homo sapiens_hsa040680.25258139
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24708744
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21388092
109ABC transporters_Homo sapiens_hsa020100.19320698
110Pentose phosphate pathway_Homo sapiens_hsa000300.19032365
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19028825
112Vibrio cholerae infection_Homo sapiens_hsa051100.18298348
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18196080
114Renal cell carcinoma_Homo sapiens_hsa052110.17456939
115MicroRNAs in cancer_Homo sapiens_hsa052060.16094658
116Notch signaling pathway_Homo sapiens_hsa043300.15754641
117mTOR signaling pathway_Homo sapiens_hsa041500.15123121
118Sphingolipid metabolism_Homo sapiens_hsa006000.14500194

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