CSF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)7.25927866
2regulation of vitamin D biosynthetic process (GO:0060556)7.12671855
3cell adhesion mediated by integrin (GO:0033627)6.80558713
4skin morphogenesis (GO:0043589)6.51739321
5mesodermal cell differentiation (GO:0048333)5.89315641
6regulation of alkaline phosphatase activity (GO:0010692)5.67144845
7regulation of vitamin metabolic process (GO:0030656)5.65266744
8wound healing, spreading of epidermal cells (GO:0035313)5.38544676
9low-density lipoprotein particle clearance (GO:0034383)5.24325868
10hypotonic response (GO:0006971)4.83123185
11positive regulation of chemokine biosynthetic process (GO:0045080)4.82742780
12hepatocyte apoptotic process (GO:0097284)4.61253212
13substrate-dependent cell migration (GO:0006929)4.58430644
14regulation of T-helper 1 cell differentiation (GO:0045625)4.50720966
15regulation of immunoglobulin secretion (GO:0051023)4.39202452
16regulation of podosome assembly (GO:0071801)4.28714797
17activation of MAPKKK activity (GO:0000185)4.18011944
18regulation of T-helper 2 cell differentiation (GO:0045628)4.15364598
19regulation of mononuclear cell migration (GO:0071675)4.11925166
20positive regulation of type 2 immune response (GO:0002830)4.10599225
21lung lobe morphogenesis (GO:0060463)4.03768060
22detection of bacterium (GO:0016045)3.98547925
23positive regulation of p38MAPK cascade (GO:1900745)3.97598904
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.97407735
25modulation by symbiont of host immune response (GO:0052553)3.97407735
26positive regulation by symbiont of host defense response (GO:0052509)3.97407735
27modulation by symbiont of host defense response (GO:0052031)3.97407735
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97407735
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97407735
30wound healing, spreading of cells (GO:0044319)3.96899509
31positive regulation of acute inflammatory response (GO:0002675)3.90107061
32detection of other organism (GO:0098543)3.88657330
33response to host (GO:0075136)3.86312483
34response to host defenses (GO:0052200)3.86312483
35response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86312483
36negative regulation of nitric oxide biosynthetic process (GO:0045019)3.82078168
37hepatocyte differentiation (GO:0070365)3.77726289
38negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.77221684
39decidualization (GO:0046697)3.75905772
40regulation of transmission of nerve impulse (GO:0051969)3.75093367
41negative regulation of lipid storage (GO:0010888)3.72880975
42positive regulation of heat generation (GO:0031652)3.71126174
43lung vasculature development (GO:0060426)3.68656560
44branching involved in labyrinthine layer morphogenesis (GO:0060670)3.67618646
45regulation of fever generation (GO:0031620)3.65723357
46renal filtration (GO:0097205)3.63796867
47lung epithelium development (GO:0060428)3.60079550
48hemidesmosome assembly (GO:0031581)3.57845831
49monocyte chemotaxis (GO:0002548)3.54781594
50regulation of chemokine biosynthetic process (GO:0045073)3.53749706
51positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.50835872
52defense response to protozoan (GO:0042832)3.48644937
53diterpenoid biosynthetic process (GO:0016102)3.47758715
54positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.44380407
55type I interferon signaling pathway (GO:0060337)3.41813711
56cellular response to type I interferon (GO:0071357)3.41813711
57response to host immune response (GO:0052572)3.40984466
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40984466
59response to type I interferon (GO:0034340)3.36550655
60establishment of endothelial barrier (GO:0061028)3.35201943
61positive regulation of NF-kappaB import into nucleus (GO:0042346)3.35136719
62negative regulation of cytokine production involved in immune response (GO:0002719)3.32459424
63regulation of interferon-alpha production (GO:0032647)3.29416169
64myeloid dendritic cell differentiation (GO:0043011)3.28160678
65germinal center formation (GO:0002467)3.27413374
66regulation of membrane protein ectodomain proteolysis (GO:0051043)3.26105596
67negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.24433183
68regulation of type 2 immune response (GO:0002828)3.23707077
69positive regulation of T-helper cell differentiation (GO:0045624)3.22332923
70regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.22016299
71CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.19030352
72positive regulation of toll-like receptor signaling pathway (GO:0034123)3.17167197
73response to muramyl dipeptide (GO:0032495)3.16861929
74T-helper 1 type immune response (GO:0042088)3.16601152
75regulation of vascular endothelial growth factor production (GO:0010574)3.14895062
76positive regulation of interleukin-6 production (GO:0032755)3.13936656
77* cellular response to lipopolysaccharide (GO:0071222)3.13235711
78adhesion of symbiont to host (GO:0044406)3.12852411
79NIK/NF-kappaB signaling (GO:0038061)3.12516555
80iron coordination entity transport (GO:1901678)3.10397635
81positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.09224444
82neutrophil activation involved in immune response (GO:0002283)3.09043215
83positive regulation of smooth muscle cell proliferation (GO:0048661)3.08444911
84muscle organ morphogenesis (GO:0048644)3.06564106
85regulation of T-helper cell differentiation (GO:0045622)3.06289277
86regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04588199
87cellular response to arsenic-containing substance (GO:0071243)3.03990506
88response to protozoan (GO:0001562)3.03818729
89virion attachment to host cell (GO:0019062)3.03447463
90adhesion of symbiont to host cell (GO:0044650)3.03447463
91regulation of cytokine secretion involved in immune response (GO:0002739)3.00378726
92positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.00314042
93macrophage activation involved in immune response (GO:0002281)2.99769592
94response to peptidoglycan (GO:0032494)2.98680408
95* cellular response to molecule of bacterial origin (GO:0071219)2.97252357
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97113088
97negative regulation of interleukin-12 production (GO:0032695)2.95547844
98myeloid cell homeostasis (GO:0002262)2.94270159
99detection of external biotic stimulus (GO:0098581)2.93970695
100positive regulation of astrocyte differentiation (GO:0048711)2.92364902
101macroautophagy (GO:0016236)2.90543447
102response to manganese ion (GO:0010042)2.87529653
103positive regulation of chemokine production (GO:0032722)2.87458363
104regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.87133589
105regulation of NF-kappaB import into nucleus (GO:0042345)2.87084641
106lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86631030
107regulation of heat generation (GO:0031650)2.86602613
108interleukin-6-mediated signaling pathway (GO:0070102)2.86372695
109positive regulation of macrophage differentiation (GO:0045651)2.84305539
110cytokine secretion (GO:0050663)2.84305265
111detection of biotic stimulus (GO:0009595)2.84182192
112lens fiber cell development (GO:0070307)2.81670808
113negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.80252090
114response to muscle activity (GO:0014850)2.80123983
115chronic inflammatory response (GO:0002544)2.80030734
116positive regulation of pseudopodium assembly (GO:0031274)2.79869375
117regulation of chronic inflammatory response (GO:0002676)2.79440369
118regulation of p38MAPK cascade (GO:1900744)2.79130344
119positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.78601979
120apoptotic process involved in morphogenesis (GO:0060561)2.78306579
121regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.76429607
122regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74925293
123respiratory tube development (GO:0030323)2.73913819
124regulation of heterotypic cell-cell adhesion (GO:0034114)2.72518273
125eosinophil chemotaxis (GO:0048245)2.70786563
126positive regulation of nitric oxide biosynthetic process (GO:0045429)2.69064646
127positive regulation of osteoblast proliferation (GO:0033690)2.68867650
128protein localization to endosome (GO:0036010)2.68671676
129interferon-gamma-mediated signaling pathway (GO:0060333)2.68592041
130regulation of interleukin-8 biosynthetic process (GO:0045414)2.67457894
131regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.66703190
132leukocyte aggregation (GO:0070486)2.66551028
133positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.66451390
134maintenance of gastrointestinal epithelium (GO:0030277)2.65567063
135tyrosine phosphorylation of STAT protein (GO:0007260)2.65118117
136regulation of interleukin-6 production (GO:0032675)2.64130906
137positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.63890775
138regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63668251
139regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.63122787
140cellular response to nicotine (GO:0071316)2.62689267
141negative regulation of production of molecular mediator of immune response (GO:0002701)2.62524098
142myeloid dendritic cell activation (GO:0001773)2.59941290
143mammary gland epithelial cell proliferation (GO:0033598)2.59918413
144detection of molecule of bacterial origin (GO:0032490)2.59791421
145cyclooxygenase pathway (GO:0019371)2.59481377
146* cellular response to biotic stimulus (GO:0071216)2.57922564
147response to vitamin D (GO:0033280)2.57034330
148positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.56905083
149regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.56905083
150regulation of nitric oxide biosynthetic process (GO:0045428)2.54991061
151positive regulation of interferon-alpha production (GO:0032727)2.54578807
152keratinocyte differentiation (GO:0030216)2.54566691
153negative regulation of amino acid transport (GO:0051956)2.53841817
154regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.51680231
155ovulation (GO:0030728)2.50377182
156positive regulation vascular endothelial growth factor production (GO:0010575)2.49339541
157negative regulation of glucose transport (GO:0010829)2.46993374
158dendritic cell differentiation (GO:0097028)2.46925681
159negative regulation of viral genome replication (GO:0045071)2.45937171
160positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45882954
161* positive regulation of transcription factor import into nucleus (GO:0042993)2.42358940
162regulation of interleukin-12 production (GO:0032655)2.42050636
163positive regulation of leukocyte migration (GO:0002687)2.41942596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.87642619
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.42199321
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.41496751
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.21688134
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.86420780
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.67081319
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.63631820
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.49108757
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.41318270
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.29610570
11ESR2_21235772_ChIP-Seq_MCF-7_Human3.15169232
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.77609600
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.49636018
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.39560596
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.39560596
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.34398580
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.30080420
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.25686491
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19362332
20CLOCK_20551151_ChIP-Seq_293T_Human2.19031057
21* GATA2_21666600_ChIP-Seq_HMVEC_Human2.18941363
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02334440
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.01601753
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.95149149
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.90344965
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89711335
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84865191
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83069746
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81341443
30SOX2_20726797_ChIP-Seq_SW620_Human1.78372276
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.73539409
32* ELK3_25401928_ChIP-Seq_HUVEC_Human1.67470353
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63237440
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.60749468
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60305960
36* ATF3_27146783_Chip-Seq_COLON_Human1.60111346
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59374620
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58152088
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.57098277
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56160501
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.54491704
42JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52829488
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52181568
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51503100
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.45801176
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45261374
47ZNF263_19887448_ChIP-Seq_K562_Human1.44805306
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43189929
49CJUN_26792858_Chip-Seq_BT549_Human1.41926909
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40139272
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40108710
52RACK7_27058665_Chip-Seq_MCF-7_Human1.38166159
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32701741
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32701741
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30917342
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29247391
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28619461
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.28488263
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28363630
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25139355
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.24706138
62VDR_21846776_ChIP-Seq_THP-1_Human1.23664294
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23553768
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23378792
65* GATA6_25053715_ChIP-Seq_YYC3_Human1.22688484
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21924476
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21555114
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21063325
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20095416
70KLF5_25053715_ChIP-Seq_YYC3_Human1.19737227
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18426673
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18155687
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16217324
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14390594
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13333426
76GATA4_25053715_ChIP-Seq_YYC3_Human1.12584428
77TCF7_22412390_ChIP-Seq_EML_Mouse1.12209315
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10973303
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10676525
80BRD4_25478319_ChIP-Seq_HGPS_Human1.10591771
81PU_27001747_Chip-Seq_BMDM_Mouse1.09891582
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09498293
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.08666451
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08488893
85SPI1_23127762_ChIP-Seq_K562_Human1.07615418
86SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07427599
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07394382
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06113792
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05815153
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05785751
91LXR_22158963_ChIP-Seq_LIVER_Mouse1.04522567
92* UBF1/2_26484160_Chip-Seq_HMECs_Human1.03067521
93* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03008742
94* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02736892
95VDR_24787735_ChIP-Seq_THP-1_Human1.02437596
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02291502
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02266142
98RUNX_20019798_ChIP-Seq_JUKART_Human1.01733104
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.00829177
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00746404
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00517279
102* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00059192
103* GATA2_19941826_ChIP-Seq_K562_Human0.99002780
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97541733
105* GATA1_19941826_ChIP-Seq_K562_Human0.96967630
106MAF_26560356_Chip-Seq_TH1_Human0.95967608
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95515821
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95508955
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94307180
110AHR_22903824_ChIP-Seq_MCF-7_Human0.94116015
111RUNX1_22412390_ChIP-Seq_EML_Mouse0.93935272
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93684953
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93111556
114* GATA3_24758297_ChIP-Seq_MCF-7_Human0.92204478
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92142557
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91625614
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91544102
118* LXR_22292898_ChIP-Seq_THP-1_Human0.91533712
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91466073
120KDM2B_26808549_Chip-Seq_K562_Human0.91222746
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90478340
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90449004
123* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89895260
124RXR_22158963_ChIP-Seq_LIVER_Mouse0.89002059
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88873922
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88873922
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88873922
128VDR_24763502_ChIP-Seq_THP-1_Human0.88653139
129KDM2B_26808549_Chip-Seq_DND41_Human0.87721803
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87504710
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85619489
132* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85507638
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84980687
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83251266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.30113339
2MP0010234_abnormal_vibrissa_follicle4.13992817
3MP0003724_increased_susceptibility_to3.28383508
4MP0009785_altered_susceptibility_to3.28214850
5MP0003300_gastrointestinal_ulcer3.12764390
6MP0004947_skin_inflammation3.03223434
7MP0000537_abnormal_urethra_morphology2.93110542
8MP0010352_gastrointestinal_tract_polyps2.81271314
9MP0002254_reproductive_system_inflammat2.79499811
10MP0003453_abnormal_keratinocyte_physiol2.64102603
11MP0005023_abnormal_wound_healing2.49988786
12MP0003436_decreased_susceptibility_to2.48499890
13MP0002332_abnormal_exercise_endurance2.38035604
14MP0003566_abnormal_cell_adhesion2.34459119
15MP0000343_altered_response_to2.25216452
16MP0004510_myositis2.19138546
17MP0008438_abnormal_cutaneous_collagen2.12925998
18MP0005076_abnormal_cell_differentiation2.12305850
19MP0005058_abnormal_lysosome_morphology2.00942989
20MP0005451_abnormal_body_composition1.97978605
21MP0001881_abnormal_mammary_gland1.93910558
22MP0001835_abnormal_antigen_presentation1.90465829
23MP0005248_abnormal_Harderian_gland1.90413783
24MP0009278_abnormal_bone_marrow1.90188292
25MP0005164_abnormal_response_to1.86495638
26MP0003091_abnormal_cell_migration1.84628148
27MP0001533_abnormal_skeleton_physiology1.82389514
28MP0010678_abnormal_skin_adnexa1.78426229
29* MP0002419_abnormal_innate_immunity1.72979957
30MP0003705_abnormal_hypodermis_morpholog1.72440152
31MP0008004_abnormal_stomach_pH1.69682119
32MP0003448_altered_tumor_morphology1.67154727
33MP0000858_altered_metastatic_potential1.64655353
34MP0005167_abnormal_blood-brain_barrier1.62978259
35MP0009840_abnormal_foam_cell1.62508855
36MP0010155_abnormal_intestine_physiology1.61695595
37* MP0005025_abnormal_response_to1.60084084
38MP0003075_altered_response_to1.59537319
39MP0001542_abnormal_bone_strength1.59300266
40MP0005166_decreased_susceptibility_to1.55479742
41MP0000627_abnormal_mammary_gland1.51663042
42MP0003279_aneurysm1.51012907
43MP0009764_decreased_sensitivity_to1.49542056
44MP0003045_fibrosis1.45309411
45MP0006054_spinal_hemorrhage1.40713451
46MP0002796_impaired_skin_barrier1.34848763
47MP0004272_abnormal_basement_membrane1.32772618
48MP0005671_abnormal_response_to1.32716124
49MP0004883_abnormal_blood_vessel1.32521422
50MP0001845_abnormal_inflammatory_respons1.31445579
51MP0002148_abnormal_hypersensitivity_rea1.31331969
52MP0001501_abnormal_sleep_pattern1.30906093
53* MP0005000_abnormal_immune_tolerance1.30205712
54MP0004858_abnormal_nervous_system1.29984769
55MP0001851_eye_inflammation1.28781576
56MP0002139_abnormal_hepatobiliary_system1.28120223
57MP0000685_abnormal_immune_system1.26856859
58MP0002998_abnormal_bone_remodeling1.24050958
59MP0003690_abnormal_glial_cell1.22265053
60MP0003191_abnormal_cellular_cholesterol1.22237964
61MP0005501_abnormal_skin_physiology1.16375300
62MP0002295_abnormal_pulmonary_circulatio1.16344093
63MP0000249_abnormal_blood_vessel1.16251864
64MP0003828_pulmonary_edema1.16055848
65MP0005257_abnormal_intraocular_pressure1.15956918
66MP0002877_abnormal_melanocyte_morpholog1.14186738
67* MP0001216_abnormal_epidermal_layer1.14003211
68MP0002452_abnormal_antigen_presenting1.13104685
69MP0005387_immune_system_phenotype1.12841557
70MP0001790_abnormal_immune_system1.12841557
71MP0005390_skeleton_phenotype1.11587939
72MP0002933_joint_inflammation1.09575015
73MP0001958_emphysema1.07797408
74MP0003866_abnormal_defecation1.07757136
75MP0002405_respiratory_system_inflammati1.06844616
76MP0002723_abnormal_immune_serum1.05379601
77MP0010368_abnormal_lymphatic_system1.04811677
78MP0000383_abnormal_hair_follicle1.04059939
79MP0003656_abnormal_erythrocyte_physiolo1.02999192
80MP0003950_abnormal_plasma_membrane1.02726722
81MP0001849_ear_inflammation0.98252273
82MP0005595_abnormal_vascular_smooth0.95485668
83MP0009763_increased_sensitivity_to0.95386153
84MP0000604_amyloidosis0.95212819
85MP0002060_abnormal_skin_morphology0.93303623
86MP0008469_abnormal_protein_level0.92385933
87MP0000750_abnormal_muscle_regeneration0.92177192
88MP0001191_abnormal_skin_condition0.91226409
89MP0000767_abnormal_smooth_muscle0.91037068
90MP0009765_abnormal_xenobiotic_induced0.90071450
91MP0005165_increased_susceptibility_to0.88912445
92MP0003806_abnormal_nucleotide_metabolis0.88727358
93MP0005464_abnormal_platelet_physiology0.88186718
94MP0002138_abnormal_hepatobiliary_system0.87869006
95MP0003115_abnormal_respiratory_system0.87266954
96MP0001346_abnormal_lacrimal_gland0.86709425
97MP0003221_abnormal_cardiomyocyte_apopto0.86491061
98MP0004264_abnormal_extraembryonic_tissu0.86095862
99MP0005310_abnormal_salivary_gland0.84917674
100MP0004808_abnormal_hematopoietic_stem0.84304708
101MP0009931_abnormal_skin_appearance0.83539802
102MP0010771_integument_phenotype0.82206557
103MP0001879_abnormal_lymphatic_vessel0.82041018
104MP0001853_heart_inflammation0.81174746
105* MP0001819_abnormal_immune_cell0.80772339
106MP0008874_decreased_physiological_sensi0.80464221
107MP0001545_abnormal_hematopoietic_system0.80322065
108MP0005397_hematopoietic_system_phenotyp0.80322065
109MP0001800_abnormal_humoral_immune0.79759879
110MP0005623_abnormal_meninges_morphology0.79755739
111* MP0002420_abnormal_adaptive_immunity0.79625620
112MP0009333_abnormal_splenocyte_physiolog0.79494618
113MP0005275_abnormal_skin_tensile0.76905870
114MP0002006_tumorigenesis0.76850271
115MP0003172_abnormal_lysosome_physiology0.76663877
116MP0001727_abnormal_embryo_implantation0.76432216
117MP0006082_CNS_inflammation0.74791804
118MP0002098_abnormal_vibrissa_morphology0.74544165
119MP0005083_abnormal_biliary_tract0.74326787
120MP0000716_abnormal_immune_system0.74283101
121MP0003195_calcinosis0.74009689
122MP0002896_abnormal_bone_mineralization0.73520492
123MP0008873_increased_physiological_sensi0.72992125
124MP0001663_abnormal_digestive_system0.71788034
125MP0002282_abnormal_trachea_morphology0.71192880
126MP0003795_abnormal_bone_structure0.70458621
127MP0005535_abnormal_body_temperature0.67192539

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)6.39213011
2Abnormality of liposaccharide metabolism (HP:0010968)5.62107391
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.62107391
4Abnormality of glycolipid metabolism (HP:0010969)5.62107391
5Micronodular cirrhosis (HP:0001413)4.83594631
6Tetraparesis (HP:0002273)4.18657021
7Onycholysis (HP:0001806)4.15336947
8Orchitis (HP:0100796)4.04275264
9Systemic lupus erythematosus (HP:0002725)3.95034419
10Stomatitis (HP:0010280)3.84786491
11Atrophic scars (HP:0001075)3.74770511
12Optic neuritis (HP:0100653)3.70912519
13Retrobulbar optic neuritis (HP:0100654)3.70912519
14Elevated erythrocyte sedimentation rate (HP:0003565)3.69345187
15Arterial tortuosity (HP:0005116)3.69098249
16Esophageal varix (HP:0002040)3.64909160
17Dysostosis multiplex (HP:0000943)3.57098058
18Neurofibrillary tangles (HP:0002185)3.56133719
19Loss of speech (HP:0002371)3.55937172
20Milia (HP:0001056)3.55602233
21Abnormality of proline metabolism (HP:0010907)3.44875983
22Hydroxyprolinuria (HP:0003080)3.44875983
23Myositis (HP:0100614)3.42966187
24Pustule (HP:0200039)3.42023614
25Nuclear cataract (HP:0100018)3.38817814
26Bronchomalacia (HP:0002780)3.36191932
27Eczematoid dermatitis (HP:0000976)3.35809256
28Vascular tortuosity (HP:0004948)3.30516937
29Focal segmental glomerulosclerosis (HP:0000097)3.25207008
30Vacuolated lymphocytes (HP:0001922)3.24708074
31Subacute progressive viral hepatitis (HP:0006572)3.21515472
32Abnormality of macrophages (HP:0004311)3.12224557
33Autoimmune thrombocytopenia (HP:0001973)3.11171282
34Amyloidosis (HP:0011034)3.03583669
35Fused cervical vertebrae (HP:0002949)3.01540384
36Thin bony cortex (HP:0002753)3.01020129
37Disinhibition (HP:0000734)3.00368715
38Fragile nails (HP:0001808)2.99161146
39Vertebral compression fractures (HP:0002953)2.96177621
40Axonal loss (HP:0003447)2.88072175
41Peritonitis (HP:0002586)2.87700186
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.84902837
43Abnormality of polysaccharide metabolism (HP:0011012)2.84902837
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.84902837
45Nail dystrophy (HP:0008404)2.82194313
46Glomerulonephritis (HP:0000099)2.81803706
47Glomerulosclerosis (HP:0000096)2.78924925
48Bowing of the arm (HP:0006488)2.77973027
49Bowed forearm bones (HP:0003956)2.77973027
50Recurrent abscess formation (HP:0002722)2.77766512
51Short nail (HP:0001799)2.73536982
52Mucopolysacchariduria (HP:0008155)2.73153683
53Urinary glycosaminoglycan excretion (HP:0003541)2.73153683
54Right ventricular cardiomyopathy (HP:0011663)2.73032083
55Premature rupture of membranes (HP:0001788)2.70408728
56Cerebral inclusion bodies (HP:0100314)2.67642641
57Ankyloglossia (HP:0010296)2.64066893
58Hematochezia (HP:0002573)2.58945749
59Aortic aneurysm (HP:0004942)2.58847856
60Thoracolumbar scoliosis (HP:0002944)2.55958790
61Increased cerebral lipofuscin (HP:0011813)2.54569413
62Mediastinal lymphadenopathy (HP:0100721)2.53088648
63Follicular hyperkeratosis (HP:0007502)2.52487553
64Radial bowing (HP:0002986)2.49924447
65Abnormality of the nasal septum (HP:0000419)2.47927535
66Choroideremia (HP:0001139)2.47156856
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.46930095
68Keratoconjunctivitis sicca (HP:0001097)2.41617610
69Episodic fever (HP:0001954)2.40678057
70Ulnar bowing (HP:0003031)2.40622149
71Myocardial infarction (HP:0001658)2.40009428
72Achilles tendon contracture (HP:0001771)2.37274498
73Mutism (HP:0002300)2.36225239
74Apathy (HP:0000741)2.33956179
75Cerebral aneurysm (HP:0004944)2.33109860
76Plantar hyperkeratosis (HP:0007556)2.32792346
77Synostosis involving the elbow (HP:0003938)2.29653141
78Humeroradial synostosis (HP:0003041)2.29653141
79Recurrent gram-negative bacterial infections (HP:0005420)2.29293582
80Cervical subluxation (HP:0003308)2.28256487
81Protrusio acetabuli (HP:0003179)2.27860143
82Xerostomia (HP:0000217)2.27567305
83Shallow orbits (HP:0000586)2.27027086
84Anorexia (HP:0002039)2.26527267
85Colitis (HP:0002583)2.25607075
86Recurrent bacterial skin infections (HP:0005406)2.23924056
87Metaphyseal irregularity (HP:0003025)2.23572848
88Menorrhagia (HP:0000132)2.23302131
89Hemorrhage of the eye (HP:0011885)2.22493409
90Complement deficiency (HP:0004431)2.22203549
91Increased serum ferritin (HP:0003281)2.21420277
92Malnutrition (HP:0004395)2.20621929
93Anhidrosis (HP:0000970)2.20197873
94Diminished motivation (HP:0000745)2.19366978
95Ankle contracture (HP:0006466)2.19354098
96Alopecia of scalp (HP:0002293)2.17938632
97Pili torti (HP:0003777)2.17865697
98Abnormal blistering of the skin (HP:0008066)2.15881119
99Hypoplasia of dental enamel (HP:0006297)2.14622194
100Stenosis of the external auditory canal (HP:0000402)2.12996382
101Type 1 muscle fiber predominance (HP:0003803)2.12924574
102Curly hair (HP:0002212)2.12255240
103Keratoconjunctivitis (HP:0001096)2.11492779
104Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10163416
105Hyperparathyroidism (HP:0000843)2.09173608
106Asymmetric septal hypertrophy (HP:0001670)2.08513041
107Abnormality of iron homeostasis (HP:0011031)2.08388932
108Aortic dissection (HP:0002647)2.08328293
109Aneurysm (HP:0002617)2.06347562
110Hemoptysis (HP:0002105)2.06344103
111Abnormality of the Achilles tendon (HP:0005109)2.06159116
112Genu recurvatum (HP:0002816)2.06068131
113Abnormality of complement system (HP:0005339)2.05185982
114Abnormality of oral frenula (HP:0000190)2.04275939
115Gangrene (HP:0100758)2.03067623
116Spondylolisthesis (HP:0003302)2.02554232
117Increased mean platelet volume (HP:0011877)2.00747197
118Increased IgM level (HP:0003496)2.00666572
119Arterial thrombosis (HP:0004420)1.97673925
120Striae distensae (HP:0001065)1.97672657
121Upper motor neuron abnormality (HP:0002127)1.97516101
122Abnormality of the common coagulation pathway (HP:0010990)1.97057249
123Slender build (HP:0001533)1.96503791
124Deep venous thrombosis (HP:0002625)1.96104125
125Urticaria (HP:0001025)1.95503104
126Abnormality of the pericardium (HP:0001697)1.95048926
127Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.94361166
128Progressive neurologic deterioration (HP:0002344)1.93743043
129Nephritis (HP:0000123)1.92423835
130Joint swelling (HP:0001386)1.92158629
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91650904
132Nausea (HP:0002018)1.91499852
133Basal ganglia calcification (HP:0002135)1.90665028
134Abnormality of the pleura (HP:0002103)1.90570320
135Bone pain (HP:0002653)1.90389552
136Rectal prolapse (HP:0002035)1.89066071
137Congenital ichthyosiform erythroderma (HP:0007431)1.88208628
138Obstructive lung disease (HP:0006536)1.86563744
139Chronic obstructive pulmonary disease (HP:0006510)1.86563744
140Fragile skin (HP:0001030)1.86298975
141Gingivitis (HP:0000230)1.83332938
142Hypergammaglobulinemia (HP:0010702)1.82730935
143Oligomenorrhea (HP:0000876)1.81969129
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.81577201
145Osteolytic defects of the hand bones (HP:0009699)1.81577201
146Parakeratosis (HP:0001036)1.81397512
147Abdominal distention (HP:0003270)1.80419594
148Premature loss of primary teeth (HP:0006323)1.80251038
149Increased density of long bones (HP:0006392)1.79898022
150Femoral bowing (HP:0002980)1.79758786
151Glomerulopathy (HP:0100820)1.78744556
152Inflammation of the large intestine (HP:0002037)1.78656385
153Emphysema (HP:0002097)1.78588443
154Pulmonary infiltrates (HP:0002113)1.78309554
155Spinal rigidity (HP:0003306)1.77015605
156Vasculitis (HP:0002633)1.74984674
157Thick nail (HP:0001805)1.74122750
158Progressive hearing impairment (HP:0001730)1.74029258
159Abnormality of the nasal mucosa (HP:0000433)1.72569829
160Abnormal platelet volume (HP:0011876)1.70551700
161Abnormality of glutamine family amino acid metabolism (HP:0010902)1.70381023
162Abnormality of transition element cation homeostasis (HP:0011030)1.70305859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK23.21133262
2NME23.21104095
3MAP3K142.73006986
4MOS2.63144130
5TBK12.59798803
6MST42.57033808
7GRK72.57005835
8EPHB12.50511798
9EPHA212.0056166
10PRPF4B1.99653884
11MST1R1.99610451
12PTK21.80815019
13RPS6KB21.71903448
14CDC42BPA1.65282271
15RIPK11.61466194
16PTK61.54193035
17BMPR21.49412820
18IRAK31.47756702
19MAP3K31.45644311
20PAK41.44149147
21ADRBK21.41019255
22IKBKE1.39027996
23ARAF1.36151280
24STK101.35484675
25TGFBR21.32159071
26BMX1.31318531
27FGFR41.30500012
28CHUK1.28588238
29NEK91.25604194
30LRRK21.25458198
31EPHB21.25163520
32IKBKB1.24986864
33MAP3K91.21233422
34ERBB41.18353492
35CSK1.17972586
36ERN11.17697529
37BLK1.17550904
38FER1.15880050
39IRAK21.08697734
40TRIB31.07935311
41IRAK11.07266608
42DMPK1.02089455
43MAP3K50.97553222
44PRKG20.95559827
45TESK10.95268104
46LATS10.89388910
47MAP2K20.89341266
48MAP3K10.89151738
49PKN20.87430454
50MET0.86637045
51EPHA30.80952611
52KSR20.79394055
53MAP2K10.78695530
54FGR0.78629847
55TYK20.78250683
56PBK0.76957289
57TXK0.75997640
58MAP4K10.73444553
59RPS6KA40.71192670
60MAP3K20.70087408
61LATS20.68878853
62MAP3K120.66427308
63EGFR0.65891093
64TGFBR10.62940230
65TTN0.62394105
66DDR20.62313094
67PAK30.62269016
68PIM20.61876998
69ALK0.61540237
70TAOK10.60186326
71MAP3K110.58138853
72TRPM70.57466507
73ABL20.57000788
74PDGFRA0.56110442
75BCR0.56072686
76SIK10.55785278
77FLT30.55425685
78TYRO30.54903001
79SIK30.53804026
80FRK0.53663697
81DYRK30.53327193
82MAP3K100.53145904
83GRK50.51069093
84PTK2B0.50568486
85CDK80.47347020
86LYN0.46436834
87GSK3A0.44470319
88ABL10.44373508
89JAK10.44270404
90CAMK2B0.43931141
91CDK60.43599641
92BRAF0.42714535
93INSR0.42186060
94HIPK20.41685064
95JAK20.40143360
96MAPKAPK20.39325262
97NTRK10.39166062
98MATK0.38525822
99PDGFRB0.36740335
100MAP2K30.36226972
101MAPK70.35829994
102ERBB30.35655309
103LCK0.34578201
104IRAK40.34032591
105RPS6KC10.34009418
106RPS6KL10.34009418
107CAMK2G0.32980935
108JAK30.32438349
109RIPK40.31848910
110MARK30.31318201
111RPS6KA20.30504962
112LIMK10.30125773
113PKN10.30113193
114CAMK2D0.29935846
115MAP3K130.29298764
116ZAP700.28579436
117PDPK10.28539644
118ICK0.28199803
119SRC0.27924847
120HCK0.27912553
121MAP3K70.27818784
122MAP3K80.27501079
123SYK0.26404778
124PIM10.25716100
125STK30.25573518
126PRKD20.25376853
127KIT0.25329718
128MELK0.25068289
129MAPK40.25013414
130STK240.24795545
131CSNK1A1L0.24629224
132PAK20.24281647
133DAPK30.23933601
134PRKCE0.23848453
135RAF10.23450131
136RPS6KA60.22504465
137CSF1R0.22370917
138CLK10.22292963
139PRKCD0.20939202
140MAP2K60.20595511

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.91590926
2TNF signaling pathway_Homo sapiens_hsa046682.73660682
3African trypanosomiasis_Homo sapiens_hsa051432.62868092
4* Malaria_Homo sapiens_hsa051442.41726152
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.39499387
6Legionellosis_Homo sapiens_hsa051342.25944388
7Small cell lung cancer_Homo sapiens_hsa052222.23169777
8Prion diseases_Homo sapiens_hsa050202.13337069
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.12199825
10Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.01749218
11Osteoclast differentiation_Homo sapiens_hsa043801.95737678
12ECM-receptor interaction_Homo sapiens_hsa045121.94549345
13* Hematopoietic cell lineage_Homo sapiens_hsa046401.92313959
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.91419194
15Staphylococcus aureus infection_Homo sapiens_hsa051501.89938967
16Other glycan degradation_Homo sapiens_hsa005111.86250375
17Rheumatoid arthritis_Homo sapiens_hsa053231.82490255
18Pertussis_Homo sapiens_hsa051331.79988437
19Shigellosis_Homo sapiens_hsa051311.79262206
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.78135590
21Amoebiasis_Homo sapiens_hsa051461.75467156
22Toxoplasmosis_Homo sapiens_hsa051451.74006569
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.68204452
24Adherens junction_Homo sapiens_hsa045201.64639901
25Salmonella infection_Homo sapiens_hsa051321.60077527
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59101375
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58096934
28Proteoglycans in cancer_Homo sapiens_hsa052051.57741750
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.51024408
30Focal adhesion_Homo sapiens_hsa045101.49143248
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46557236
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40876276
33Tuberculosis_Homo sapiens_hsa051521.39426938
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.38592150
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38364583
36Apoptosis_Homo sapiens_hsa042101.38209029
37Graft-versus-host disease_Homo sapiens_hsa053321.36816458
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29913553
39Hepatitis C_Homo sapiens_hsa051601.26934764
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26790499
41Bladder cancer_Homo sapiens_hsa052191.24894456
42Asthma_Homo sapiens_hsa053101.24596352
43Chronic myeloid leukemia_Homo sapiens_hsa052201.21306708
44Phagosome_Homo sapiens_hsa041451.21067944
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19248102
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11731763
47Pancreatic cancer_Homo sapiens_hsa052121.11467530
48Mineral absorption_Homo sapiens_hsa049781.10290230
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09634596
50Influenza A_Homo sapiens_hsa051641.07450590
51Autoimmune thyroid disease_Homo sapiens_hsa053201.06555005
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05835591
53VEGF signaling pathway_Homo sapiens_hsa043701.04950286
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.04928866
55Tight junction_Homo sapiens_hsa045301.03911213
56Viral myocarditis_Homo sapiens_hsa054161.03172182
57Dilated cardiomyopathy_Homo sapiens_hsa054141.02318308
58* Jak-STAT signaling pathway_Homo sapiens_hsa046300.98740482
59MicroRNAs in cancer_Homo sapiens_hsa052060.96564699
60Type I diabetes mellitus_Homo sapiens_hsa049400.96471790
61Allograft rejection_Homo sapiens_hsa053300.93784929
62* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92073926
63B cell receptor signaling pathway_Homo sapiens_hsa046620.89729622
64Sulfur metabolism_Homo sapiens_hsa009200.87961656
65Renal cell carcinoma_Homo sapiens_hsa052110.87594902
66Dorso-ventral axis formation_Homo sapiens_hsa043200.86651827
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.86538193
68HIF-1 signaling pathway_Homo sapiens_hsa040660.84197332
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83799880
70Measles_Homo sapiens_hsa051620.83798421
71Hepatitis B_Homo sapiens_hsa051610.80630701
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79443754
73Platelet activation_Homo sapiens_hsa046110.69711733
74Pathways in cancer_Homo sapiens_hsa052000.69210069
75Lysosome_Homo sapiens_hsa041420.68858399
76Chemokine signaling pathway_Homo sapiens_hsa040620.67343354
77Hippo signaling pathway_Homo sapiens_hsa043900.67221831
78Rap1 signaling pathway_Homo sapiens_hsa040150.66924586
79Prolactin signaling pathway_Homo sapiens_hsa049170.66452433
80* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65569847
81Acute myeloid leukemia_Homo sapiens_hsa052210.65433601
82Sphingolipid metabolism_Homo sapiens_hsa006000.62992714
83HTLV-I infection_Homo sapiens_hsa051660.62700319
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62619527
85Complement and coagulation cascades_Homo sapiens_hsa046100.60389212
86p53 signaling pathway_Homo sapiens_hsa041150.59533352
87MAPK signaling pathway_Homo sapiens_hsa040100.57942685
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57763143
89Insulin resistance_Homo sapiens_hsa049310.57419605
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55020221
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53886416
92Herpes simplex infection_Homo sapiens_hsa051680.53693248
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53399803
94Thyroid cancer_Homo sapiens_hsa052160.49783033
95T cell receptor signaling pathway_Homo sapiens_hsa046600.49457305
96Endocytosis_Homo sapiens_hsa041440.49320672
97Antigen processing and presentation_Homo sapiens_hsa046120.48690231
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47561048
99FoxO signaling pathway_Homo sapiens_hsa040680.47088001
100Viral carcinogenesis_Homo sapiens_hsa052030.46406057
101Colorectal cancer_Homo sapiens_hsa052100.45388560
102Epstein-Barr virus infection_Homo sapiens_hsa051690.44944256
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44741208
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43943260
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43922180
106Type II diabetes mellitus_Homo sapiens_hsa049300.43648768
107Galactose metabolism_Homo sapiens_hsa000520.43556956
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42689407
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.42298065
110TGF-beta signaling pathway_Homo sapiens_hsa043500.40070808
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39684850
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.38456193
113Prostate cancer_Homo sapiens_hsa052150.38454088
114Fructose and mannose metabolism_Homo sapiens_hsa000510.38394483
115Endometrial cancer_Homo sapiens_hsa052130.38323855
116mTOR signaling pathway_Homo sapiens_hsa041500.37196326
117Vibrio cholerae infection_Homo sapiens_hsa051100.36739423
118ErbB signaling pathway_Homo sapiens_hsa040120.35829181
119Melanoma_Homo sapiens_hsa052180.34574482
120PPAR signaling pathway_Homo sapiens_hsa033200.30055938
121GnRH signaling pathway_Homo sapiens_hsa049120.25583137
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.22788130

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