CSH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen metabolic process (GO:0008209)9.80611733
2positive regulation of growth hormone secretion (GO:0060124)9.52613649
3multi-organism reproductive process (GO:0044703)9.35484635
4glucocorticoid metabolic process (GO:0008211)7.99808240
5hormone biosynthetic process (GO:0042446)7.24576730
6regulation of growth hormone secretion (GO:0060123)6.78248516
7myoblast fusion (GO:0007520)6.33760337
8JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)6.31677078
9collecting duct development (GO:0072044)6.23361266
10vitamin transmembrane transport (GO:0035461)6.21758556
11response to gonadotropin (GO:0034698)6.13533693
12positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-6.04981772
13syncytium formation (GO:0006949)5.89842614
14syncytium formation by plasma membrane fusion (GO:0000768)5.63822152
15positive regulation of protein kinase C signaling (GO:0090037)5.37100724
16endocrine hormone secretion (GO:0060986)5.18015668
17negative regulation of activin receptor signaling pathway (GO:0032926)5.12906573
18lymphangiogenesis (GO:0001946)4.80124768
19sphingoid metabolic process (GO:0046519)4.79566522
20cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.66763392
21vascular endothelial growth factor signaling pathway (GO:0038084)4.65908124
22bone morphogenesis (GO:0060349)4.33973301
23positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.16528420
24T-helper 1 type immune response (GO:0042088)4.16359663
25protein neddylation (GO:0045116)4.15943902
26regulation of interferon-gamma biosynthetic process (GO:0045072)4.10045902
27lymph vessel development (GO:0001945)4.07096854
28estrogen biosynthetic process (GO:0006703)32.7963625
29myelin maintenance (GO:0043217)3.94528695
30L-alpha-amino acid transmembrane transport (GO:1902475)3.62474446
31vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.41367189
32cellular hormone metabolic process (GO:0034754)3.40957526
33interkinetic nuclear migration (GO:0022027)3.40711843
34parturition (GO:0007567)3.34512731
35regulation of endocrine process (GO:0044060)3.34389968
36JAK-STAT cascade (GO:0007259)3.29365362
37negative regulation of smooth muscle cell differentiation (GO:0051151)3.27521391
38sprouting angiogenesis (GO:0002040)3.26801076
39eyelid development in camera-type eye (GO:0061029)3.13938458
40positive regulation of insulin receptor signaling pathway (GO:0046628)3.12741323
41regulation of G0 to G1 transition (GO:0070316)3.07651842
42sequestering of extracellular ligand from receptor (GO:0035581)3.06923723
43keratinocyte development (GO:0003334)3.04844820
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01722868
45iron ion import (GO:0097286)2.88425831
46steroid biosynthetic process (GO:0006694)2.82348411
47ear development (GO:0043583)2.74557529
48progesterone metabolic process (GO:0042448)2.66976740
49mitotic cytokinesis (GO:0000281)2.64292086
50negative regulation of cell-matrix adhesion (GO:0001953)2.64089611
51basement membrane organization (GO:0071711)2.63461172
52transcytosis (GO:0045056)2.56651097
53polarized epithelial cell differentiation (GO:0030859)2.51492077
54positive regulation of alpha-beta T cell proliferation (GO:0046641)2.51092015
55C21-steroid hormone biosynthetic process (GO:0006700)2.44819186
56regulation of protein kinase C signaling (GO:0090036)2.42822279
57sphingosine metabolic process (GO:0006670)2.36710826
58cytoskeleton-dependent cytokinesis (GO:0061640)2.34041790
59ketone biosynthetic process (GO:0042181)2.33869285
60Sertoli cell development (GO:0060009)2.33190735
61hormone metabolic process (GO:0042445)2.31068506
62cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.28961686
63regulation of calcium ion-dependent exocytosis (GO:0017158)2.18447435
64regulation of ruffle assembly (GO:1900027)2.15617931
65negative regulation of macrophage differentiation (GO:0045650)2.15356292
66response to phenylpropanoid (GO:0080184)2.13194254
67blood vessel morphogenesis (GO:0048514)2.10815087
68response to inactivity (GO:0014854)2.10712227
69regulation of activin receptor signaling pathway (GO:0032925)2.10201865
70positive regulation of cellular response to insulin stimulus (GO:1900078)2.08079760
71diol metabolic process (GO:0034311)2.07954058
72positive regulation of T cell cytokine production (GO:0002726)2.06580442
73regulation of T-helper 2 cell differentiation (GO:0045628)2.01915367
74regulation of alpha-beta T cell proliferation (GO:0046640)2.01099848
75response to follicle-stimulating hormone (GO:0032354)15.7052413
76female pregnancy (GO:0007565)14.8121421
77regulation of gonadotropin secretion (GO:0032276)14.2034923
78estrogen metabolic process (GO:0008210)14.1095322
79glucocorticoid biosynthetic process (GO:0006704)13.5701868
80prostate gland growth (GO:0060736)13.3488194
81androgen biosynthetic process (GO:0006702)11.3311639
82multi-multicellular organism process (GO:0044706)10.7313626
83regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.99925050
84apical protein localization (GO:0045176)1.99741713
85mating behavior (GO:0007617)1.95842843
86female genitalia development (GO:0030540)1.94803881
87vitamin D metabolic process (GO:0042359)1.94117312
88insulin-like growth factor receptor signaling pathway (GO:0048009)1.91193107
89thyroid hormone generation (GO:0006590)1.90996893
90Leydig cell differentiation (GO:0033327)1.88920138
91negative regulation of Ras protein signal transduction (GO:0046580)1.88880922
92lung vasculature development (GO:0060426)1.88385761
93response to vitamin E (GO:0033197)1.87087688
94regulation of clathrin-mediated endocytosis (GO:2000369)1.86260335
95negative regulation of small GTPase mediated signal transduction (GO:0051058)1.82478578
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.79665549
97cellular response to gonadotropin stimulus (GO:0071371)1.79637059
98protein targeting to Golgi (GO:0000042)1.79609475
99negative regulation of myoblast differentiation (GO:0045662)1.79269154
100neuronal ion channel clustering (GO:0045161)1.78472860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19032775_ChIP-ChIP_M12_Human5.91007224
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.48889313
3TRIM28_17542650_ChIP-ChIP_NTERA2_Human3.10725447
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.98287417
5BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.89585407
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.62486310
7AHR_22903824_ChIP-Seq_MCF-7_Human2.56952707
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.53123131
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.44431370
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24098074
11TP53_18474530_ChIP-ChIP_U2OS_Human2.20225150
12PPAR_26484153_Chip-Seq_NCI-H1993_Human2.09455777
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human13.5371125
14ARNT_22903824_ChIP-Seq_MCF-7_Human1.99856933
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.95703348
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.95645894
17JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.91758575
18ZNF263_19887448_ChIP-Seq_K562_Human1.86872161
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81179943
20P63_26484246_Chip-Seq_KERATINOCYTES_Human1.79902599
21SCL_19346495_ChIP-Seq_HPC-7_Human1.76371397
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74422351
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.72237157
24BRD4_25478319_ChIP-Seq_HGPS_Human1.64950623
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.54083683
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.53303910
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41462343
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38558222
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38558222
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37416264
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32402196
32GATA3_24758297_ChIP-Seq_MCF-7_Human1.28613692
33VDR_24787735_ChIP-Seq_THP-1_Human1.28295460
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27644643
35PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.26500108
36ER_23166858_ChIP-Seq_MCF-7_Human1.25262129
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25223104
38CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23147994
39RXR_22108803_ChIP-Seq_LS180_Human1.19579090
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.19517183
41AR_21572438_ChIP-Seq_LNCaP_Human1.19108825
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18719089
43CBP_20019798_ChIP-Seq_JUKART_Human1.14141300
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14141300
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13862459
46KLF4_19829295_ChIP-Seq_ESCs_Human1.12427778
47TP63_23658742_ChIP-Seq_EP156T_Human1.08348189
48SMAD3_21741376_ChIP-Seq_HESCs_Human1.06215201
49TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03616806
50TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03570151
51SOX2_20726797_ChIP-Seq_SW620_Human1.02864463
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02708087
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00709750
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00709750
55EWS_26573619_Chip-Seq_HEK293_Human1.00580335
56HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98154775
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98015093
58GATA1_19941826_ChIP-Seq_K562_Human0.97520104
59POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96145091
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95829852
61ISL1_27105846_Chip-Seq_CPCs_Mouse0.95519255
62ERG_20517297_ChIP-Seq_VCAP_Human0.94793757
63CJUN_26792858_Chip-Seq_BT549_Human0.94556350
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94015984
65EP300_21415370_ChIP-Seq_HL-1_Mouse0.93910803
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93177453
67EGR1_19374776_ChIP-ChIP_THP-1_Human0.93126801
68CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90976161
69RUNX2_22187159_ChIP-Seq_PCA_Human0.89802157
70JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89349692
71FUS_26573619_Chip-Seq_HEK293_Human0.88656561
72FOXA2_19822575_ChIP-Seq_HepG2_Human0.88012887
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87593783
74RNF2_27304074_Chip-Seq_ESCs_Mouse0.87512857
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87006458
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85527953
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85462595
78JUN_21703547_ChIP-Seq_K562_Human0.84587544
79JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83852380
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83815657
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82434848
82HTT_18923047_ChIP-ChIP_STHdh_Human0.82040934
83UBF1/2_26484160_Chip-Seq_HMECs_Human0.80467814
84TAF15_26573619_Chip-Seq_HEK293_Human0.80188090
85AR_19668381_ChIP-Seq_PC3_Human0.78636125
86FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76284761
87FOXA1_25329375_ChIP-Seq_VCAP_Human0.76284761
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76149600
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76149600
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75329726
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.74597245
92* P300_19829295_ChIP-Seq_ESCs_Human0.74513078
93GATA4_25053715_ChIP-Seq_YYC3_Human0.74161810
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.73527807
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.73516134
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73060646
97SA1_22415368_ChIP-Seq_MEFs_Mouse0.71805635
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71455977
99RUNX_20019798_ChIP-Seq_JUKART_Human0.70449571
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.69611674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology7.14530312
2MP0005379_endocrine/exocrine_gland_phen5.43331861
3MP0006276_abnormal_autonomic_nervous4.95700181
4MP0005647_abnormal_sex_gland3.89040527
5MP0010368_abnormal_lymphatic_system3.76215015
6MP0001919_abnormal_reproductive_system3.65751885
7MP0000013_abnormal_adipose_tissue3.09458186
8MP0003959_abnormal_lean_body2.52884799
9MP0001440_abnormal_grooming_behavior2.52280229
10MP0003941_abnormal_skin_development2.47166709
11MP0000003_abnormal_adipose_tissue2.44212491
12MP0004019_abnormal_vitamin_homeostasis2.25804808
13MP0006054_spinal_hemorrhage2.19815985
14MP0005389_reproductive_system_phenotype2.04823397
15MP0002876_abnormal_thyroid_physiology2.00082125
16MP0009697_abnormal_copulation11.8630221
17MP0001666_abnormal_nutrient_absorption1.90451244
18MP0009115_abnormal_fat_cell1.89052706
19MP0002653_abnormal_ependyma_morphology1.77076453
20MP0000613_abnormal_salivary_gland1.67923154
21MP0006138_congestive_heart_failure1.59422471
22MP0003936_abnormal_reproductive_system1.57035148
23MP0002971_abnormal_brown_adipose1.50208597
24MP0000639_abnormal_adrenal_gland1.44314535
25MP0010329_abnormal_lipoprotein_level1.42545768
26MP0000647_abnormal_sebaceous_gland1.40988854
27MP0009703_decreased_birth_body1.39059095
28MP0001879_abnormal_lymphatic_vessel1.38056725
29MP0002998_abnormal_bone_remodeling1.35892121
30MP0005375_adipose_tissue_phenotype1.32226040
31MP0002075_abnormal_coat/hair_pigmentati1.31556811
32MP0003453_abnormal_keratinocyte_physiol1.21131038
33MP0001756_abnormal_urination1.16730807
34MP0005023_abnormal_wound_healing1.05472214
35MP0004947_skin_inflammation1.04679725
36MP0002909_abnormal_adrenal_gland1.03731675
37MP0001186_pigmentation_phenotype0.88812459
38MP0005334_abnormal_fat_pad0.88240071
39MP0004085_abnormal_heartbeat0.86746414
40MP0004185_abnormal_adipocyte_glucose0.84660316
41MP0001765_abnormal_ion_homeostasis0.84150202
42MP0010352_gastrointestinal_tract_polyps0.79941290
43MP0003136_yellow_coat_color0.78769082
44MP0000230_abnormal_systemic_arterial0.77797294
45MP0002128_abnormal_blood_circulation0.77259125
46MP0002557_abnormal_social/conspecific_i0.75525604
47MP0001915_intracranial_hemorrhage0.72736535
48MP0000685_abnormal_immune_system0.71929193
49MP0002086_abnormal_extraembryonic_tissu0.70638562
50MP0003566_abnormal_cell_adhesion0.69140573
51MP0002972_abnormal_cardiac_muscle0.66491555
52MP0005319_abnormal_enzyme/_coenzyme0.65628275
53MP0005409_darkened_coat_color0.65445918
54MP0003950_abnormal_plasma_membrane0.64799319
55MP0003567_abnormal_fetal_cardiomyocyte0.62314773
56MP0003122_maternal_imprinting0.61107686
57MP0003795_abnormal_bone_structure0.60747448
58MP0003385_abnormal_body_wall0.60259373
59MP0001340_abnormal_eyelid_morphology0.59458230
60MP0000681_abnormal_thyroid_gland0.57013247
61MP0003705_abnormal_hypodermis_morpholog0.55872271
62MP0004145_abnormal_muscle_electrophysio0.54003620
63MP0004272_abnormal_basement_membrane0.53682388
64MP0005452_abnormal_adipose_tissue0.53439826
65MP0000367_abnormal_coat/_hair0.52994692
66MP0001119_abnormal_female_reproductive0.52811974
67MP0004782_abnormal_surfactant_physiolog0.51167876
68MP0005636_abnormal_mineral_homeostasis0.50455521
69MP0002210_abnormal_sex_determination0.50293181
70MP0004381_abnormal_hair_follicle0.49115483
71MP0003699_abnormal_female_reproductive0.49062462
72MP0003828_pulmonary_edema0.47669731
73MP0005076_abnormal_cell_differentiation0.44096552
74MP0000598_abnormal_liver_morphology0.43249258
75MP0009780_abnormal_chondrocyte_physiolo0.42989634
76MP0000383_abnormal_hair_follicle0.42928406
77MP0001544_abnormal_cardiovascular_syste0.41101477
78MP0005385_cardiovascular_system_phenoty0.41101477
79MP0000266_abnormal_heart_morphology0.40059792
80MP0003953_abnormal_hormone_level0.38612676
81MP0000759_abnormal_skeletal_muscle0.35679968
82MP0003724_increased_susceptibility_to0.34985539
83MP0003183_abnormal_peptide_metabolism0.34746217
84MP0002295_abnormal_pulmonary_circulatio0.32929309
85MP0005397_hematopoietic_system_phenotyp0.30728655
86MP0001545_abnormal_hematopoietic_system0.30728655
87MP0005666_abnormal_adipose_tissue0.30052162
88MP0003091_abnormal_cell_migration0.29913802
89MP0000747_muscle_weakness0.27762155
90MP0001929_abnormal_gametogenesis0.27705436
91MP0002925_abnormal_cardiovascular_devel0.27675553
92MP0000627_abnormal_mammary_gland0.26991603
93MP0001188_hyperpigmentation0.26627336
94MP0002136_abnormal_kidney_physiology0.26165634
95MP0003191_abnormal_cellular_cholesterol0.25964717
96MP0008057_abnormal_DNA_replication0.25368472
97MP0001614_abnormal_blood_vessel0.23757722
98MP0000653_abnormal_sex_gland0.23413215
99MP0010678_abnormal_skin_adnexa0.22460740
100MP0005187_abnormal_penis_morphology0.21874167

Predicted human phenotypes

RankGene SetZ-score
1Hypergonadotropic hypogonadism (HP:0000815)9.11050811
2Upper limb muscle weakness (HP:0003484)8.78449792
3Decreased number of large peripheral myelinated nerve fibers (HP:0003387)8.67734898
4Abnormal pupillary function (HP:0007686)6.91526264
5Muscle fibrillation (HP:0010546)6.55086711
6Nonimmune hydrops fetalis (HP:0001790)6.42305311
7Tongue fasciculations (HP:0001308)6.21639963
8Abnormal auditory evoked potentials (HP:0006958)6.12941769
9Accelerated skeletal maturation (HP:0005616)6.11031961
10Female pseudohermaphroditism (HP:0010458)5.70663265
11Anosmia (HP:0000458)5.48119852
12Back pain (HP:0003418)4.63674607
13Lower limb asymmetry (HP:0100559)4.52033259
14Gynecomastia (HP:0000771)4.19584039
15Hypogonadotrophic hypogonadism (HP:0000044)3.93967013
16Basal cell carcinoma (HP:0002671)3.89071345
17Abnormality of the ischium (HP:0003174)3.88882446
18Bilateral microphthalmos (HP:0007633)3.74268476
19Long palpebral fissure (HP:0000637)3.47451359
20Primary amenorrhea (HP:0000786)3.43575485
21Onion bulb formation (HP:0003383)3.38229526
22Abnormal pancreas size (HP:0012094)3.22390685
23Pseudobulbar signs (HP:0002200)3.17145408
24Sex reversal (HP:0012245)3.11002098
25Abnormal sex determination (HP:0012244)3.11002098
26Long eyelashes (HP:0000527)3.04802990
27Areflexia of lower limbs (HP:0002522)3.02460910
28Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.01660428
29Disproportionate tall stature (HP:0001519)3.01120045
30Testicular neoplasm (HP:0010788)2.99658579
31Genu valgum (HP:0002857)2.95675435
32Abnormality of the aortic arch (HP:0012303)2.93581766
33Venous insufficiency (HP:0005293)2.88658652
34Peripheral demyelination (HP:0011096)2.79835905
35Bilateral sensorineural hearing impairment (HP:0008619)2.74991516
36Wormian bones (HP:0002645)2.73787870
37Decreased motor nerve conduction velocity (HP:0003431)2.63820597
38Bicornuate uterus (HP:0000813)2.62993592
39Polycythemia (HP:0001901)2.62880407
40Delayed gross motor development (HP:0002194)2.60853932
41Asymmetric growth (HP:0100555)2.58998348
42Difficulty walking (HP:0002355)2.50763835
43Hyperaldosteronism (HP:0000859)2.40316996
44Congenital ichthyosiform erythroderma (HP:0007431)2.39930010
45Venous abnormality (HP:0002624)2.38251229
46Abnormality of the pupil (HP:0000615)2.31097400
47Spontaneous hematomas (HP:0007420)2.30287648
48Hypoplastic nipples (HP:0002557)2.29579569
49Mutism (HP:0002300)2.26426755
50Hematochezia (HP:0002573)2.26079116
51Short tibia (HP:0005736)2.26041171
52Arteriovenous malformation (HP:0100026)2.23506883
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.16970048
54Abnormality of glycolipid metabolism (HP:0010969)2.16482713
55Abnormality of liposaccharide metabolism (HP:0010968)2.16482713
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.16482713
57Anophthalmia (HP:0000528)2.16266796
58Annular pancreas (HP:0001734)2.13423302
59Flat cornea (HP:0007720)2.13102919
60Hypoplasia of the uterus (HP:0000013)2.11648713
61Fragile skin (HP:0001030)2.10277588
62Hyporeflexia of lower limbs (HP:0002600)2.09256635
63Distal lower limb muscle weakness (HP:0009053)2.05909613
64Aplasia of the musculature (HP:0100854)2.05794282
65Cardiovascular calcification (HP:0011915)2.02266426
66Morphological abnormality of the middle ear (HP:0008609)2.01436013
67Capillary hemangiomas (HP:0005306)10.1030035
68Renal salt wasting (HP:0000127)1.97464266
69Decreased circulating renin level (HP:0003351)1.92239299
70Abnormal autonomic nervous system physiology (HP:0012332)1.87881805
71Ulnar deviation of finger (HP:0009465)1.85131094
72Coarctation of aorta (HP:0001680)1.84452839
73Ectopic kidney (HP:0000086)1.84063699
74Long clavicles (HP:0000890)1.83879017
75Right ventricular cardiomyopathy (HP:0011663)1.83822616
76Hypoplasia of the iris (HP:0007676)1.82944002
77Confusion (HP:0001289)1.82829848
78Severe Myopia (HP:0011003)1.81033108
79Sparse lateral eyebrow (HP:0005338)1.75702765
80Hypohidrosis (HP:0000966)1.74800238
81Eczematoid dermatitis (HP:0000976)1.74749538
82Lymphedema (HP:0001004)1.74393980
83Deep philtrum (HP:0002002)1.72784637
84Fasciculations (HP:0002380)1.71918511
85Blue sclerae (HP:0000592)1.71469118
86Cerebral aneurysm (HP:0004944)1.67541233
87Hyperpituitarism (HP:0010514)1.66826861
88Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.62909062
89Abnormality of incisor morphology (HP:0011063)1.62166149
90Aortic aneurysm (HP:0004942)1.61692968
91Breast hypoplasia (HP:0003187)1.61360495
92Myotonia (HP:0002486)1.61068075
93Abnormal lung lobation (HP:0002101)1.59503831
94Abnormality of secondary sexual hair (HP:0009888)1.53563814
95Abnormality of the axillary hair (HP:0100134)1.53563814
96Abnormality of the nasolacrimal system (HP:0000614)1.51236132
97Aplasia cutis congenita (HP:0001057)1.50595698
98Teleangiectasia of the skin (HP:0100585)1.50291776
99Osteolytic defects of the hand bones (HP:0009699)1.50256218
100Osteolytic defects of the phalanges of the hand (HP:0009771)1.50256218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDGFRA6.64581912
2AKT35.85016631
3DAPK24.74873552
4BLK2.96749178
5ICK2.56892852
6PDGFRB2.54426711
7MST42.37424529
8KDR10.6190829
9TIE11.82637501
10DAPK11.73866854
11PKN11.52476649
12NEK91.25093236
13ERBB41.18373441
14DAPK31.10356217
15MAP3K71.07988799
16INSR1.07947707
17RIPK11.06549276
18PDPK11.05587031
19SRC1.03782132
20RPS6KA20.98867723
21EGFR0.93637305
22LATS10.90608119
23FRK0.85535052
24INSRR0.85138485
25RPS6KA60.75170873
26RPS6KL10.74067205
27RPS6KC10.74067205
28TYK20.73897055
29STK380.72382915
30FES0.67307620
31PTK60.66165604
32MAPK130.64446844
33STK100.61723318
34MET0.61088207
35JAK20.60823537
36TGFBR20.60435619
37YES10.59144070
38MARK20.59031083
39AKT20.57215972
40TRPM70.52145570
41PRKCZ0.51741794
42PDK10.51400419
43PRKD20.45814673
44SGK2230.44007122
45SGK4940.44007122
46PRKD10.42639418
47LYN0.41626013
48AURKB0.39141441
49EPHA20.38177749
50SGK10.37349012
51MAP2K10.37234703
52BRD40.37202816
53NME10.37058178
54MAPK40.36771067
55MTOR0.35670703
56DYRK1B0.34835949
57FER0.33703320
58CDC42BPA0.33693929
59LCK0.32107229
60MAPK110.31569273
61PRKCQ0.31031857
62MYLK0.29815641
63SMG10.28762360
64HCK0.28605071
65PRKCA0.26340608
66MELK0.23719047
67ERBB20.23468500
68EPHB20.23394698
69TXK0.22681999
70TAF10.21360701
71MAP3K120.20956285
72PRKAA10.19880510
73CAMK40.18956067
74ERBB30.18915073
75PTK2B0.18573265
76PRKAA20.18533289
77MAPK10.17869114
78KIT0.16515954
79PRKCE0.16417438
80MAP3K90.15086522
81SGK30.13979121
82RPS6KA10.12623883
83STK30.12213329
84STK240.12165857
85SGK20.11711570
86MAPK80.11528412
87MAPK30.11058204
88ROCK10.10268751
89FGFR30.10057195
90PRKCB0.09716585
91CAMK2G0.09488841
92ROCK20.08603560
93TESK20.08390964
94CAMK1D0.07774446
95MAP3K40.07697650
96TBK10.07387093
97MAP2K20.06407806
98BMPR20.06304215
99PIK3CA0.06111199
100CSF1R0.06043482

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049139.72566328
2Steroid hormone biosynthesis_Homo sapiens_hsa001408.41961507
3* Jak-STAT signaling pathway_Homo sapiens_hsa046303.07434770
4Folate biosynthesis_Homo sapiens_hsa007902.56534091
5Aldosterone synthesis and secretion_Homo sapiens_hsa049252.40691972
6N-Glycan biosynthesis_Homo sapiens_hsa005102.09162311
7Sphingolipid metabolism_Homo sapiens_hsa006001.95955649
8Renin-angiotensin system_Homo sapiens_hsa046141.92105530
9Mineral absorption_Homo sapiens_hsa049781.91830141
10* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.57114077
11* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46644634
12Histidine metabolism_Homo sapiens_hsa003401.34506263
13Vitamin digestion and absorption_Homo sapiens_hsa049771.22229977
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21900389
15Salivary secretion_Homo sapiens_hsa049701.19263637
16Inositol phosphate metabolism_Homo sapiens_hsa005621.17957472
17Axon guidance_Homo sapiens_hsa043601.14649215
18Ras signaling pathway_Homo sapiens_hsa040141.08028574
19Tryptophan metabolism_Homo sapiens_hsa003801.05422813
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03354617
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96380143
22Focal adhesion_Homo sapiens_hsa045100.96114834
23Renal cell carcinoma_Homo sapiens_hsa052110.93418619
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93132876
25Sphingolipid signaling pathway_Homo sapiens_hsa040710.92807606
26Dorso-ventral axis formation_Homo sapiens_hsa043200.91630017
27Prolactin signaling pathway_Homo sapiens_hsa049170.89744248
28ECM-receptor interaction_Homo sapiens_hsa045120.85277020
29Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82652258
30Rap1 signaling pathway_Homo sapiens_hsa040150.70859435
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69507794
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68521294
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67422407
34Malaria_Homo sapiens_hsa051440.64600495
35Thyroid hormone synthesis_Homo sapiens_hsa049180.58981629
36Bladder cancer_Homo sapiens_hsa052190.55737001
37Tight junction_Homo sapiens_hsa045300.54730903
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53526981
39HIF-1 signaling pathway_Homo sapiens_hsa040660.49576382
40Adherens junction_Homo sapiens_hsa045200.49196541
41Autoimmune thyroid disease_Homo sapiens_hsa053200.48811640
42Other glycan degradation_Homo sapiens_hsa005110.48514983
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.48462556
44Endocytosis_Homo sapiens_hsa041440.45227231
45Insulin resistance_Homo sapiens_hsa049310.44057553
46Prostate cancer_Homo sapiens_hsa052150.43912159
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43844772
48Small cell lung cancer_Homo sapiens_hsa052220.42698192
49Proteoglycans in cancer_Homo sapiens_hsa052050.42470376
50Type II diabetes mellitus_Homo sapiens_hsa049300.41748666
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41523682
52FoxO signaling pathway_Homo sapiens_hsa040680.41436202
53GnRH signaling pathway_Homo sapiens_hsa049120.40201294
54Pathways in cancer_Homo sapiens_hsa052000.38107716
55Complement and coagulation cascades_Homo sapiens_hsa046100.38072419
56ErbB signaling pathway_Homo sapiens_hsa040120.36696441
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35591975
58TGF-beta signaling pathway_Homo sapiens_hsa043500.34881690
59Acute myeloid leukemia_Homo sapiens_hsa052210.34177486
60Chronic myeloid leukemia_Homo sapiens_hsa052200.33566505
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.31735775
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30686618
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29601891
64Platelet activation_Homo sapiens_hsa046110.29037270
65MAPK signaling pathway_Homo sapiens_hsa040100.28087507
66Endometrial cancer_Homo sapiens_hsa052130.27198122
67Fatty acid biosynthesis_Homo sapiens_hsa000610.26473129
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23869261
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23696687
70Metabolic pathways_Homo sapiens_hsa011000.22365392
71Hippo signaling pathway_Homo sapiens_hsa043900.22314397
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21537122
73Amoebiasis_Homo sapiens_hsa051460.21522106
74Choline metabolism in cancer_Homo sapiens_hsa052310.21014684
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.19439486
76Estrogen signaling pathway_Homo sapiens_hsa049150.18612861
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18393627
78Hepatitis B_Homo sapiens_hsa051610.17660849
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17143220
80Arginine and proline metabolism_Homo sapiens_hsa003300.16377378
81MicroRNAs in cancer_Homo sapiens_hsa052060.16115217
82Glioma_Homo sapiens_hsa052140.15092601
83Nicotine addiction_Homo sapiens_hsa050330.14877753
84Phenylalanine metabolism_Homo sapiens_hsa003600.13574379
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12990499
86Chemokine signaling pathway_Homo sapiens_hsa040620.12723398
87Toxoplasmosis_Homo sapiens_hsa051450.12571397
88Non-small cell lung cancer_Homo sapiens_hsa052230.12052317
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11117593
90Hepatitis C_Homo sapiens_hsa051600.10800894
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10207550
92Insulin signaling pathway_Homo sapiens_hsa049100.10157475
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09687400
94Gastric acid secretion_Homo sapiens_hsa049710.09657466
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.09545764
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09396353
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.08826185
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.08513299
99Melanogenesis_Homo sapiens_hsa049160.08251120
100GABAergic synapse_Homo sapiens_hsa047270.08186716

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »