CSN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)8.75178341
2intestinal cholesterol absorption (GO:0030299)8.24801639
3fatty-acyl-CoA biosynthetic process (GO:0046949)7.11689553
4long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.99666390
5alpha-linolenic acid metabolic process (GO:0036109)6.98363993
6regulation of vascular endothelial growth factor signaling pathway (GO:1900746)6.90755599
7acyl-CoA biosynthetic process (GO:0071616)6.89959998
8thioester biosynthetic process (GO:0035384)6.89959998
9regulation of sequestering of triglyceride (GO:0010889)6.73814503
10cholesterol catabolic process (GO:0006707)6.69569184
11sterol catabolic process (GO:0016127)6.69569184
12negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.62433847
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)6.39999796
14regulation of phospholipid biosynthetic process (GO:0071071)6.39856451
15positive regulation of p38MAPK cascade (GO:1900745)6.39114288
16phospholipid homeostasis (GO:0055091)6.30931942
17pyrimidine-containing compound transmembrane transport (GO:0072531)6.13565295
18linoleic acid metabolic process (GO:0043651)5.86439659
19mammary gland epithelial cell differentiation (GO:0060644)5.79609783
20fatty acid transmembrane transport (GO:1902001)5.78117262
21intestinal absorption (GO:0050892)5.75702872
22ectoderm development (GO:0007398)5.53407152
23ceramide catabolic process (GO:0046514)5.36950140
24long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.36673897
25transcytosis (GO:0045056)5.28731632
26phagocytosis, recognition (GO:0006910)5.28193479
27carnitine shuttle (GO:0006853)5.21091660
28negative regulation of protein kinase B signaling (GO:0051898)5.20290847
29low-density lipoprotein particle clearance (GO:0034383)5.14082744
30biotin metabolic process (GO:0006768)5.12722762
31fatty-acyl-CoA metabolic process (GO:0035337)5.11851249
32mitochondrial calcium ion transport (GO:0006851)5.00438804
33positive regulation of osteoblast proliferation (GO:0033690)5.00185006
34tooth mineralization (GO:0034505)4.95843450
35segment specification (GO:0007379)4.90990731
36positive regulation of macrophage cytokine production (GO:0060907)4.87261186
37* lactation (GO:0007595)4.85848860
38nucleoside transmembrane transport (GO:1901642)4.82643455
39negative regulation of endothelial cell proliferation (GO:0001937)4.74203246
40regulation of p38MAPK cascade (GO:1900744)4.50696214
41regulation of penile erection (GO:0060405)4.48087573
42nucleobase catabolic process (GO:0046113)4.41650636
43GDP-mannose metabolic process (GO:0019673)4.40805808
44regulation of apoptotic cell clearance (GO:2000425)4.39798110
45acetyl-CoA metabolic process (GO:0006084)4.34456966
46regulation of triglyceride biosynthetic process (GO:0010866)4.30940960
47embryonic process involved in female pregnancy (GO:0060136)4.21381405
48response to phenylpropanoid (GO:0080184)4.19404337
49triglyceride biosynthetic process (GO:0019432)4.18418035
50O-glycan processing (GO:0016266)4.16434521
51N-acetylneuraminate metabolic process (GO:0006054)4.14466019
52lipid storage (GO:0019915)4.12226924
53* secretion by tissue (GO:0032941)4.11525596
54response to host immune response (GO:0052572)4.10805273
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.10805273
56regulation of macrophage cytokine production (GO:0010935)4.10169218
57CDP-diacylglycerol biosynthetic process (GO:0016024)4.05514227
58long-chain fatty acid transport (GO:0015909)4.03929700
59tricarboxylic acid metabolic process (GO:0072350)4.03292169
60regulation of triglyceride metabolic process (GO:0090207)4.00899244
61neutral lipid biosynthetic process (GO:0046460)4.00634347
62acylglycerol biosynthetic process (GO:0046463)4.00634347
63positive regulation of triglyceride metabolic process (GO:0090208)3.96947502
64regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.96348702
65folic acid transport (GO:0015884)3.95010176
66Golgi transport vesicle coating (GO:0048200)3.89839333
67COPI coating of Golgi vesicle (GO:0048205)3.89839333
68positive regulation of reactive oxygen species metabolic process (GO:2000379)3.88922696
69growth hormone receptor signaling pathway (GO:0060396)3.84901390
70carnitine transmembrane transport (GO:1902603)3.83359550
71glutathione biosynthetic process (GO:0006750)3.79797978
72regulation of cholesterol storage (GO:0010885)3.79689009
73negative regulation of lipid catabolic process (GO:0050995)3.79661980
74negative regulation of epithelial cell differentiation (GO:0030857)3.78760454
75positive regulation of lipid storage (GO:0010884)3.77766518
76coenzyme A biosynthetic process (GO:0015937)3.72008576
77CDP-diacylglycerol metabolic process (GO:0046341)3.71308098
78nucleotide-sugar biosynthetic process (GO:0009226)3.71130528
79triglyceride catabolic process (GO:0019433)3.70633970
80regulation of apoptotic process involved in morphogenesis (GO:1902337)3.68915805
81response to host (GO:0075136)3.65288856
82response to host defenses (GO:0052200)3.65288856
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.65288856
84nucleoside transport (GO:0015858)3.63788055
85positive regulation of triglyceride lipase activity (GO:0061365)3.62956265
86positive regulation of lipoprotein lipase activity (GO:0051006)3.62956265
87nonribosomal peptide biosynthetic process (GO:0019184)3.59502413
88cellular carbohydrate biosynthetic process (GO:0034637)3.58625038
89fatty acid transport (GO:0015908)3.57772097
90valine metabolic process (GO:0006573)3.55982217
91galactose metabolic process (GO:0006012)3.55580957
92regulation of clathrin-mediated endocytosis (GO:2000369)3.54051166
93regulation of vasculogenesis (GO:2001212)3.49814200
94positive regulation of toll-like receptor signaling pathway (GO:0034123)3.49210719
95carnitine transport (GO:0015879)3.48964521
96amino-acid betaine transport (GO:0015838)3.48964521
97regulation of execution phase of apoptosis (GO:1900117)3.48813151
98regulation of endothelial cell differentiation (GO:0045601)3.44598710
99* body fluid secretion (GO:0007589)3.44574948
100pentose-phosphate shunt (GO:0006098)3.40257310
101acylglycerol catabolic process (GO:0046464)3.37143993
102neutral lipid catabolic process (GO:0046461)3.37143993
103positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.36534776
104positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.35824365
105copper ion transport (GO:0006825)3.33358606
106purine nucleobase metabolic process (GO:0006144)3.28581887
107branched-chain amino acid metabolic process (GO:0009081)3.27494677
108positive regulation of chemokine secretion (GO:0090197)3.27098995
109negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.24123268
110mitochondrion distribution (GO:0048311)3.23687402
111cellular response to growth hormone stimulus (GO:0071378)3.23196037
112sphingolipid catabolic process (GO:0030149)3.22625312
113temperature homeostasis (GO:0001659)3.22403800
114positive regulation of triglyceride biosynthetic process (GO:0010867)3.19814898
115branched-chain amino acid catabolic process (GO:0009083)3.18608533
116negative regulation of fatty acid transport (GO:2000192)3.16257815
117oligosaccharide metabolic process (GO:0009311)3.15011376
118acyl-CoA metabolic process (GO:0006637)3.14957260
119thioester metabolic process (GO:0035383)3.14957260
120antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14808682
121antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14808682
122adhesion of symbiont to host (GO:0044406)3.13549251
123heme transport (GO:0015886)3.13108172
124regulation of fatty acid oxidation (GO:0046320)3.11961846
125localization within membrane (GO:0051668)3.11766938
126regulation of triglyceride catabolic process (GO:0010896)3.11011220
127intracellular lipid transport (GO:0032365)3.08415755
128white fat cell differentiation (GO:0050872)3.07351853
129steroid catabolic process (GO:0006706)3.05538376
130triglyceride metabolic process (GO:0006641)3.05332280
131proximal/distal pattern formation (GO:0009954)3.03249527
132NADPH regeneration (GO:0006740)3.01355058
133zinc ion transport (GO:0006829)3.00317314
134angiogenesis involved in wound healing (GO:0060055)3.00107829
135negative regulation of lipid storage (GO:0010888)2.96159985
136regulation of lipid storage (GO:0010883)2.94026288
137regulation of chemokine secretion (GO:0090196)2.93005790
138negative regulation of cell fate commitment (GO:0010454)2.91441002
139negative regulation of execution phase of apoptosis (GO:1900118)2.88514174
140membrane lipid catabolic process (GO:0046466)2.87653493
141acylglycerol metabolic process (GO:0006639)2.85520913
142hemidesmosome assembly (GO:0031581)2.84194495
143antigen processing and presentation of endogenous antigen (GO:0019883)2.83774031
144coenzyme A metabolic process (GO:0015936)2.83504268
145positive regulation of histone deacetylation (GO:0031065)2.83213704
146neutral lipid metabolic process (GO:0006638)2.81549163
147short-chain fatty acid metabolic process (GO:0046459)2.81018650
148detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.79785165
149acrosome assembly (GO:0001675)2.75785916
150regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.68760639
151nucleoside diphosphate biosynthetic process (GO:0009133)2.67207604
152peptide biosynthetic process (GO:0043043)2.57498642
153negative regulation of leukocyte migration (GO:0002686)2.55171351
154ether lipid metabolic process (GO:0046485)2.52523599
155one-carbon metabolic process (GO:0006730)2.48650657
156digestive system process (GO:0022600)2.48283064
157positive regulation of macrophage activation (GO:0043032)2.46132266
158detection of molecule of bacterial origin (GO:0032490)2.45602685
159citrulline biosynthetic process (GO:0019240)2.45107558
160oligosaccharide biosynthetic process (GO:0009312)10.5365829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.85482985
2* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse6.67574896
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.57456703
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.23977000
5CLOCK_20551151_ChIP-Seq_293T_Human3.80259628
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.79222337
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.56248013
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.99946765
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.89665512
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.86720899
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84207256
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.74787846
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.67989821
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54700810
15ZNF263_19887448_ChIP-Seq_K562_Human2.48780223
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.45075449
17AR_21572438_ChIP-Seq_LNCaP_Human2.18862087
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.13433745
19SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.08897901
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.03876607
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02948935
22ESR1_15608294_ChIP-ChIP_MCF-7_Human2.01730030
23PPARA_22158963_ChIP-Seq_LIVER_Mouse2.00045282
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98227698
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86127951
26FLI1_21867929_ChIP-Seq_CD8_Mouse1.83662918
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.81199335
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77819634
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75296404
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69279686
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67739642
32SOX2_20726797_ChIP-Seq_SW620_Human1.63787220
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63173144
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56591723
35RXR_22108803_ChIP-Seq_LS180_Human1.54787164
36PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.49100767
37HTT_18923047_ChIP-ChIP_STHdh_Human1.44885682
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44668943
39CTCF_26484167_Chip-Seq_Bcells_Mouse1.44276797
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43799293
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41800799
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40745799
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.37559050
44PU.1_20513432_ChIP-Seq_Bcells_Mouse1.36432666
45RACK7_27058665_Chip-Seq_MCF-7_Human1.34978488
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.31430655
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31389452
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30495996
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.30389884
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29240644
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29117028
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.28593784
53STAT1_20625510_ChIP-Seq_HELA_Human1.27876336
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26372310
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.25812958
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25272471
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24473224
58PU_27001747_Chip-Seq_BMDM_Mouse1.22980658
59LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.21350190
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.20664477
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20479808
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19973615
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19867667
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18831035
65KLF5_25053715_ChIP-Seq_YYC3_Human1.18276274
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.17043390
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.17043390
68RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16540245
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15455614
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14319862
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14297168
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.14174287
73GATA1_22025678_ChIP-Seq_K562_Human1.13279398
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12721086
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12594490
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12531361
77GATA4_25053715_ChIP-Seq_YYC3_Human1.12212405
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09837753
79GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.08330864
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06291747
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05792658
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05548094
83LXR_22292898_ChIP-Seq_THP-1_Human1.04521394
84JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03681752
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03128191
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02027647
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01639279
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01461944
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01167648
90PU1_27457419_Chip-Seq_LIVER_Mouse1.00260175
91GATA3_24758297_ChIP-Seq_MCF-7_Human0.99975254
92LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98449440
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96336556
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96189635
95MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95989201
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.95545504
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93946230
98SMC4_20622854_ChIP-Seq_HELA_Human0.93937069
99ATF3_27146783_Chip-Seq_COLON_Human0.93820343
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93529053
101KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93307386
102CJUN_26792858_Chip-Seq_BT549_Human0.92954499
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.92906184
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90933549
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90498514
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89264716
107GATA1_19941826_ChIP-Seq_K562_Human0.88924503
108ERG_20517297_ChIP-Seq_VCAP_Human0.88227935
109ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87220707
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86859820
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85535419
112FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85303746
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.85193306
114STAT1_17558387_ChIP-Seq_HELA_Human0.83750383
115STAT3_18555785_Chip-Seq_ESCs_Mouse0.83451509
116STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.82647843
117TDRD3_21172665_ChIP-Seq_MCF-7_Human0.82281632
118SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81606020
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81450174
120CBP_21632823_ChIP-Seq_H3396_Human0.81404946
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81368409
122SA1_27219007_Chip-Seq_ERYTHROID_Human0.81138981
123TP53_18474530_ChIP-ChIP_U2OS_Human0.79514343
124P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78809885
125NFYA_21822215_ChIP-Seq_K562_Human0.78606924
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78458104
127CREB1_26743006_Chip-Seq_LNCaP_Human0.78278697
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77996857
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77913352
130CBX2_22325352_ChIP-Seq_293T-Rex_Human0.77623703
131KDM2B_26808549_Chip-Seq_K562_Human0.77556378
132FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76651624
133GATA2_19941826_ChIP-Seq_K562_Human0.76233182
134NANOG_18692474_ChIP-Seq_MEFs_Mouse0.76178382
135POU5F1_16518401_ChIP-PET_MESCs_Mouse0.76105789
136OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75852818
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75764240
138ZFP281_27345836_Chip-Seq_ESCs_Mouse0.75325122
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74445522
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74445522
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74011620
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.73991496
143TP63_23658742_ChIP-Seq_EP156T_Human0.73901139
144NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73657184
145SMC1_22415368_ChIP-Seq_MEFs_Mouse0.70724639
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70449881
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70164980
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.69383552
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.69331339
150CHD1_26751641_Chip-Seq_LNCaP_Human0.69196538
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.69048666
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.68394693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.81394787
2MP0010234_abnormal_vibrissa_follicle4.41856813
3MP0002254_reproductive_system_inflammat3.78820225
4MP0000627_abnormal_mammary_gland3.28341945
5MP0004130_abnormal_muscle_cell3.23659014
6MP0003303_peritoneal_inflammation3.23585181
7MP0005083_abnormal_biliary_tract2.99107611
8MP0003300_gastrointestinal_ulcer2.89485373
9MP0005670_abnormal_white_adipose2.84404248
10MP0004019_abnormal_vitamin_homeostasis2.78166947
11MP0004147_increased_porphyrin_level2.53318886
12MP0003011_delayed_dark_adaptation2.44074662
13MP0001873_stomach_inflammation2.41839122
14MP0003705_abnormal_hypodermis_morpholog2.40054071
15MP0005666_abnormal_adipose_tissue2.27268693
16MP0004185_abnormal_adipocyte_glucose2.04660937
17* MP0001881_abnormal_mammary_gland10.8143885
18MP0002796_impaired_skin_barrier1.94375475
19MP0005360_urolithiasis1.87163076
20MP0004043_abnormal_pH_regulation1.79353093
21MP0004264_abnormal_extraembryonic_tissu1.76557012
22MP0005645_abnormal_hypothalamus_physiol1.69717314
23MP0005375_adipose_tissue_phenotype1.66377199
24MP0005410_abnormal_fertilization1.60846176
25MP0005085_abnormal_gallbladder_physiolo1.57454900
26MP0004272_abnormal_basement_membrane1.54568111
27MP0010329_abnormal_lipoprotein_level1.53434473
28MP0000013_abnormal_adipose_tissue1.42862710
29MP0001879_abnormal_lymphatic_vessel1.38846527
30MP0002098_abnormal_vibrissa_morphology1.38338963
31MP0002118_abnormal_lipid_homeostasis1.36886387
32MP0008438_abnormal_cutaneous_collagen1.31033046
33MP0000678_abnormal_parathyroid_gland1.28900181
34MP0008004_abnormal_stomach_pH1.28190098
35MP0003724_increased_susceptibility_to1.28026772
36MP0005076_abnormal_cell_differentiation1.22713515
37MP0009278_abnormal_bone_marrow1.20988536
38MP0005058_abnormal_lysosome_morphology1.20558612
39MP0001664_abnormal_digestion1.17928134
40MP0001666_abnormal_nutrient_absorption1.10263026
41MP0009764_decreased_sensitivity_to1.05358173
42MP0002971_abnormal_brown_adipose1.03718383
43MP0000003_abnormal_adipose_tissue1.03235520
44MP0002396_abnormal_hematopoietic_system1.00802223
45MP0003566_abnormal_cell_adhesion0.99990454
46MP0005501_abnormal_skin_physiology0.96320321
47MP0005275_abnormal_skin_tensile0.95040550
48MP0000377_abnormal_hair_follicle0.93990674
49MP0005448_abnormal_energy_balance0.92120887
50MP0002970_abnormal_white_adipose0.89012529
51MP0001663_abnormal_digestive_system0.88900411
52MP0002009_preneoplasia0.87994290
53MP0005164_abnormal_response_to0.87933968
54MP0003448_altered_tumor_morphology0.87066873
55MP0005334_abnormal_fat_pad0.86930071
56MP0009765_abnormal_xenobiotic_induced0.86251635
57MP0010678_abnormal_skin_adnexa0.86030185
58MP0005171_absent_coat_pigmentation0.85458555
59MP0001851_eye_inflammation0.85294091
60MP0005584_abnormal_enzyme/coenzyme_acti0.85185324
61MP0002139_abnormal_hepatobiliary_system0.83506756
62MP0000609_abnormal_liver_physiology0.82647379
63MP0003690_abnormal_glial_cell0.82311119
64MP0008260_abnormal_autophagy0.81801827
65MP0010352_gastrointestinal_tract_polyps0.80557486
66MP0003045_fibrosis0.80361931
67MP0003936_abnormal_reproductive_system0.80123442
68MP0003075_altered_response_to0.78605385
69MP0001727_abnormal_embryo_implantation0.78149405
70MP0005535_abnormal_body_temperature0.76273528
71MP0001984_abnormal_olfaction0.75592018
72MP0004947_skin_inflammation0.73993781
73MP0001765_abnormal_ion_homeostasis0.73985511
74MP0001533_abnormal_skeleton_physiology0.73449756
75MP0009379_abnormal_foot_pigmentation0.73186845
76MP0003950_abnormal_plasma_membrane0.72632318
77MP0001849_ear_inflammation0.72599340
78MP0000613_abnormal_salivary_gland0.71708059
79MP0002168_other_aberrant_phenotype0.71208907
80MP0005220_abnormal_exocrine_pancreas0.71151622
81MP0005381_digestive/alimentary_phenotyp0.70346273
82MP0000343_altered_response_to0.69811922
83MP0002060_abnormal_skin_morphology0.68552183
84MP0005386_behavior/neurological_phenoty0.68493053
85MP0004924_abnormal_behavior0.68493053
86MP0009384_cardiac_valve_regurgitation0.66994771
87MP0005023_abnormal_wound_healing0.66954744
88MP0001958_emphysema0.66735890
89MP0005365_abnormal_bile_salt0.65487027
90MP0005332_abnormal_amino_acid0.65015251
91MP0000639_abnormal_adrenal_gland0.64344259
92MP0003453_abnormal_keratinocyte_physiol0.64187843
93MP0008770_decreased_survivor_rate0.64101444
94MP0001216_abnormal_epidermal_layer0.63895159
95MP0009643_abnormal_urine_homeostasis0.63658206
96MP0002166_altered_tumor_susceptibility0.63325805
97MP0002896_abnormal_bone_mineralization0.63196383
98MP0000490_abnormal_crypts_of0.62674590
99MP0003959_abnormal_lean_body0.62611655
100MP0002332_abnormal_exercise_endurance0.62096511
101MP0000750_abnormal_muscle_regeneration0.59353504
102MP0009115_abnormal_fat_cell0.57932346
103MP0005452_abnormal_adipose_tissue0.57826506
104MP0005636_abnormal_mineral_homeostasis0.57788310
105MP0005167_abnormal_blood-brain_barrier0.57572945
106MP0000858_altered_metastatic_potential0.56871438
107MP0004858_abnormal_nervous_system0.56644467
108MP0002078_abnormal_glucose_homeostasis0.56013384
109MP0005319_abnormal_enzyme/_coenzyme0.55556050
110MP0006054_spinal_hemorrhage0.54109675
111MP0003828_pulmonary_edema0.53882307
112MP0001348_abnormal_lacrimal_gland0.52161269
113MP0002295_abnormal_pulmonary_circulatio0.51646467
114MP0003953_abnormal_hormone_level0.51345609
115MP0005165_increased_susceptibility_to0.49849875
116MP0009763_increased_sensitivity_to0.48975365
117MP0004883_abnormal_blood_vessel0.48914642
118MP0001545_abnormal_hematopoietic_system0.48530774
119MP0005397_hematopoietic_system_phenotyp0.48530774
120MP0000759_abnormal_skeletal_muscle0.48410286
121MP0002148_abnormal_hypersensitivity_rea0.48289467
122MP0001544_abnormal_cardiovascular_syste0.47506523
123MP0005385_cardiovascular_system_phenoty0.47506523
124MP0009931_abnormal_skin_appearance0.47432653
125MP0001177_atelectasis0.46721022
126MP0002282_abnormal_trachea_morphology0.44913361
127MP0002133_abnormal_respiratory_system0.43803751
128MP0003172_abnormal_lysosome_physiology0.43791993
129MP0002135_abnormal_kidney_morphology0.43559315
130MP0009642_abnormal_blood_homeostasis0.43245900
131MP0000371_diluted_coat_color0.36900434
132MP0009785_altered_susceptibility_to0.36842982
133MP0008789_abnormal_olfactory_epithelium0.36549905
134MP0004782_abnormal_surfactant_physiolog0.35557304
135MP0001756_abnormal_urination0.34622223
136MP0003195_calcinosis0.33708999
137MP0001542_abnormal_bone_strength0.32252223
138MP0008874_decreased_physiological_sensi0.31809876
139MP0005394_taste/olfaction_phenotype0.30828334
140MP0005499_abnormal_olfactory_system0.30828334
141MP0001764_abnormal_homeostasis0.30488527
142MP0000537_abnormal_urethra_morphology0.30235263
143MP0002089_abnormal_postnatal_growth/wei0.28399914
144MP0001853_heart_inflammation0.27561274
145MP0002693_abnormal_pancreas_physiology0.26169829
146MP0003638_abnormal_response/metabolism_0.25281466
147MP0000598_abnormal_liver_morphology0.23545281
148MP0003315_abnormal_perineum_morphology0.22475729
149MP0002419_abnormal_innate_immunity0.21095469
150MP0003984_embryonic_growth_retardation0.20798466

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.02907084
2Decreased circulating renin level (HP:0003351)6.77315428
3Abnormality of purine metabolism (HP:0004352)6.16181748
4Amelogenesis imperfecta (HP:0000705)5.33897561
5Axonal loss (HP:0003447)5.13054378
6Gout (HP:0001997)4.90352131
7Hypokalemic alkalosis (HP:0001949)4.58209596
8Congenital ichthyosiform erythroderma (HP:0007431)4.32453442
9Hyperkalemia (HP:0002153)4.08095098
10Thin bony cortex (HP:0002753)4.06129511
11Hyperlipoproteinemia (HP:0010980)4.04383444
12Overgrowth (HP:0001548)4.01176419
13Aortic aneurysm (HP:0004942)3.93716882
14Chronic bronchitis (HP:0004469)3.92498781
15Hydronephrosis (HP:0000126)3.91628262
16Pili torti (HP:0003777)3.86830871
17Abnormality of calcium-phosphate metabolism (HP:0100530)3.77952706
18Hyperaldosteronism (HP:0000859)3.75864916
19Right ventricular cardiomyopathy (HP:0011663)3.71780916
20Abnormality of nucleobase metabolism (HP:0010932)3.69707523
21Nephritis (HP:0000123)3.59186992
22Myocardial infarction (HP:0001658)3.52867995
23Symptomatic seizures (HP:0011145)3.43638334
24Stridor (HP:0010307)3.36444135
25Aortic dissection (HP:0002647)3.31344355
26Skin nodule (HP:0200036)3.26058133
27Hypotension (HP:0002615)3.22501017
28Cerebral aneurysm (HP:0004944)3.19024085
29Abnormality of renin-angiotensin system (HP:0000847)3.15326287
30Hyponatremia (HP:0002902)3.12683825
31Curly hair (HP:0002212)3.08841327
32Hyperuricemia (HP:0002149)3.03244586
33Increased purine levels (HP:0004368)3.03244586
34Metaphyseal irregularity (HP:0003025)3.00422895
35Abnormal tarsal ossification (HP:0008369)2.98283511
36Subcapsular cataract (HP:0000523)2.97806392
37Tubulointerstitial nephritis (HP:0001970)2.90173153
38Metaphyseal dysplasia (HP:0100255)2.89608572
39Abnormality of chloride homeostasis (HP:0011422)2.89174656
40Xanthomatosis (HP:0000991)2.89083666
41Abnormality of renal excretion (HP:0011036)2.88379369
42Protuberant abdomen (HP:0001538)2.87115683
43Atrophic scars (HP:0001075)2.84225498
44Enlarged epiphyses (HP:0010580)2.78252240
45Flat acetabular roof (HP:0003180)2.77749026
46Bone cyst (HP:0012062)2.77042431
47Neurodegeneration (HP:0002180)2.76011344
48Nausea (HP:0002018)2.69528283
49Tubulointerstitial fibrosis (HP:0005576)2.67778144
50Delayed epiphyseal ossification (HP:0002663)2.64066539
51Abnormality of renal resorption (HP:0011038)2.62748304
52Ectropion (HP:0000656)2.60498252
53Abnormality of sodium homeostasis (HP:0010931)2.54241852
54Glomerulosclerosis (HP:0000096)2.52820927
55Buphthalmos (HP:0000557)2.47140837
56Abnormal auditory evoked potentials (HP:0006958)2.47109137
57Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45749474
58Onycholysis (HP:0001806)2.40564492
59Ketoacidosis (HP:0001993)2.39557728
60Deep venous thrombosis (HP:0002625)2.39354802
61Aneurysm (HP:0002617)2.39286574
62Turricephaly (HP:0000262)2.39089718
63Hyperparathyroidism (HP:0000843)2.36633470
64Adrenal overactivity (HP:0002717)2.34945106
65Abnormality of the nasal mucosa (HP:0000433)2.30565839
66Intrahepatic cholestasis (HP:0001406)2.29542360
67Hyperglycinuria (HP:0003108)2.29539394
68Rickets (HP:0002748)2.29150801
69Milia (HP:0001056)2.27126593
70Alkalosis (HP:0001948)2.26651567
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.26413875
72Hypoplasia of the iris (HP:0007676)2.25900737
73Asymmetry of the thorax (HP:0001555)2.22639185
74Abnormal hair laboratory examination (HP:0003328)2.22349540
75Hypoplasia of dental enamel (HP:0006297)2.17199963
76Abnormality of transition element cation homeostasis (HP:0011030)2.16588090
77Premature loss of primary teeth (HP:0006323)2.15583579
78Abnormal epiphyseal ossification (HP:0010656)2.14687429
79Renal salt wasting (HP:0000127)2.14577105
80Epiphyseal dysplasia (HP:0002656)2.13237246
81Vacuolated lymphocytes (HP:0001922)2.11530995
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10414220
83Metabolic acidosis (HP:0001942)2.10195564
84Premature skin wrinkling (HP:0100678)2.08967422
85Long toe (HP:0010511)2.08879440
86Insulin-resistant diabetes mellitus (HP:0000831)2.08798820
87Autoamputation (HP:0001218)2.07836482
88Hypercholesterolemia (HP:0003124)2.07102005
89Esophageal varix (HP:0002040)2.06597596
90Loss of speech (HP:0002371)2.06186861
91Abdominal distention (HP:0003270)2.05980628
92Osteolytic defects of the hand bones (HP:0009699)2.05808837
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.05808837
94Retrobulbar optic neuritis (HP:0100654)2.05452515
95Optic neuritis (HP:0100653)2.05452515
96Elevated alkaline phosphatase (HP:0003155)2.04903396
97Alopecia of scalp (HP:0002293)2.04706167
98Enlarged penis (HP:0000040)2.04393630
99Acanthosis nigricans (HP:0000956)2.03237992
100Difficulty running (HP:0009046)2.01975506
101Nephrolithiasis (HP:0000787)2.01968022
102Hyperglycinemia (HP:0002154)2.01836930
103Hypertriglyceridemia (HP:0002155)2.01645046
104Hepatosplenomegaly (HP:0001433)2.01148693
105Azoospermia (HP:0000027)2.00343333
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99999526
107Glomerulonephritis (HP:0000099)1.99795823
108Nasal polyposis (HP:0100582)1.96771804
109Conjunctival hamartoma (HP:0100780)1.96326282
110Abnormality of dental color (HP:0011073)1.96304195
111Hematochezia (HP:0002573)1.96006169
112Hypokalemia (HP:0002900)1.94893105
113Abnormal hemoglobin (HP:0011902)1.93923018
114Arterial tortuosity (HP:0005116)1.92807191
115Fatigue (HP:0012378)1.92662021
116Polar cataract (HP:0010696)1.90684114
117Cortical dysplasia (HP:0002539)1.90262629
118Orchitis (HP:0100796)1.90159023
119Tetraparesis (HP:0002273)1.88623752
120Hypophosphatemia (HP:0002148)1.88031824
121Protrusio acetabuli (HP:0003179)1.86910421
122Wide cranial sutures (HP:0010537)1.85952944
123Ankle contracture (HP:0006466)1.84881132
124Widely patent fontanelles and sutures (HP:0004492)1.84447479
125Abnormal enzyme/coenzyme activity (HP:0012379)1.82589741
126Epiphyseal stippling (HP:0010655)1.82214444
127Oligomenorrhea (HP:0000876)1.81749539
128Vascular tortuosity (HP:0004948)1.81427370
129Paraparesis (HP:0002385)1.81103827
130Increased serum ferritin (HP:0003281)1.81027171
131Tubular atrophy (HP:0000092)1.80559186
132Abnormality of the dental pulp (HP:0006479)1.80426408
133Abnormality of the anterior chamber (HP:0000593)1.80101785
134Pancreatitis (HP:0001733)1.77988329
135Ketosis (HP:0001946)1.77915265
136Abnormality of alkaline phosphatase activity (HP:0004379)1.75859411
137Congenital glaucoma (HP:0001087)1.75774291
138Abnormality of the costochondral junction (HP:0000919)1.75008029
139Back pain (HP:0003418)1.73707042
140Striae distensae (HP:0001065)1.73568079
141Lymphangioma (HP:0100764)1.73403250
142Peripheral demyelination (HP:0011096)1.71874564
143Abnormality of the renal cortex (HP:0011035)1.71673078
144Abnormality of the periventricular white matter (HP:0002518)1.71164973
145Primary adrenal insufficiency (HP:0008207)1.71083168
146Epidermoid cyst (HP:0200040)1.70959007
147Abnormality of serine family amino acid metabolism (HP:0010894)1.70790713
148Abnormality of glycine metabolism (HP:0010895)1.70790713
149Poor eye contact (HP:0000817)1.70705594
150Biliary tract neoplasm (HP:0100574)1.70601151
151Spastic tetraparesis (HP:0001285)1.70183782
152Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68065192
153Abnormality of fatty-acid metabolism (HP:0004359)1.67371894
154Genu varum (HP:0002970)1.66021319
155Asymmetric septal hypertrophy (HP:0001670)1.65137235
156Flat occiput (HP:0005469)1.63487966
157Reduced antithrombin III activity (HP:0001976)1.62698966
158Dysostosis multiplex (HP:0000943)1.62547789
159Dehydration (HP:0001944)1.60956539
160Opisthotonus (HP:0002179)1.59049631
161Tubulointerstitial abnormality (HP:0001969)1.54417022
162Abnormal foot bone ossification (HP:0010675)1.51429867
163Ventricular fibrillation (HP:0001663)1.50847043
164Congenital sensorineural hearing impairment (HP:0008527)1.48008868
165Abnormality of potassium homeostasis (HP:0011042)1.47044067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK15.47600780
2PKN24.87488190
3CAMK1D4.76128000
4TRIB34.17748204
5CAMK1G3.67385216
6ERN13.34256171
7EEF2K2.99816447
8ICK2.92095399
9MAP2K62.86343734
10PDK22.64229887
11ARAF2.54976642
12PTK62.51089780
13PDK42.45415260
14PDK32.45415260
15NME22.23212212
16BCKDK1.98857298
17PIK3CA1.97347163
18RIPK11.95618472
19EPHB11.95182902
20TGFBR21.93380203
21DAPK21.72876358
22MAPKAPK31.72258456
23MAP3K91.71955109
24MYLK1.71086201
25BMPR21.65016138
26PDGFRB1.58827076
27IRAK11.54723876
28LATS11.51184802
29TIE11.45054593
30EPHA31.42895783
31SCYL21.40206385
32ZAP701.37802630
33MOS1.34105273
34RET1.32307823
35BRAF1.31525647
36LRRK21.28308602
37PRKAA21.25429749
38MAP3K131.24087907
39TBK11.13478506
40FER1.11413350
41MAP3K71.08064245
42NLK1.07797738
43STK161.06909704
44MAP3K61.05203670
45MAPK120.96997220
46DDR20.96189611
47MAP3K140.95764525
48RPS6KB20.95298533
49PINK10.91962809
50TESK20.88710883
51STK380.88423322
52BMX0.87166113
53FGFR40.87107359
54JAK20.79819227
55MATK0.79198943
56JAK30.78381729
57RPS6KB10.75819384
58RIPK40.75729126
59STK390.74054404
60GSK3A0.73681562
61MAPKAPK50.72962753
62CAMK2D0.72931122
63PAK20.71791958
64SGK30.71621816
65PTK20.71390897
66LIMK10.70628306
67PIM10.66891874
68FRK0.66309367
69PIK3CG0.65547935
70IRAK40.64773493
71STK38L0.64228076
72CAMK2G0.63459869
73WNK40.63401044
74PRKCD0.62880130
75CDK90.61549865
76IRAK20.61507878
77PTK2B0.60985176
78TRPM70.58702976
79CAMK2B0.57698642
80JAK10.57315971
81MAP2K20.56316240
82KDR0.55533296
83IGF1R0.55404651
84TAOK20.54524752
85BCR0.54390253
86CAMK10.53320300
87TAOK10.52817192
88DAPK30.52476870
89PRKCG0.51923544
90MAP3K20.51717974
91EIF2AK10.51446995
92EPHB20.51240514
93MET0.48120567
94SGK4940.47685980
95SGK2230.47685980
96PDGFRA0.47445364
97GRK70.46911262
98MAP3K30.46296676
99ILK0.46190245
100PRKAA10.46041927
101SGK20.43426365
102TAOK30.43049058
103TYRO30.41780166
104RPS6KA20.40899578
105LMTK20.39125251
106CHUK0.37947451
107PRKD10.37550697
108LATS20.37081401
109MTOR0.36388093
110PDPK10.35680926
111DYRK20.34829878
112NEK60.34411885
113EIF2AK20.33830879
114EIF2AK30.33004532
115TESK10.32833630
116SRC0.32676416
117IKBKE0.32672173
118PAK40.32220347
119TTN0.32053884
120PDK10.31510072
121FGFR30.31493471
122MAP2K10.30957088
123FGR0.29795381
124CAMKK10.29299619
125CSK0.28335069
126KSR20.28275825
127RAF10.28153154
128MAPK110.27324547
129FLT30.27094936
130TYK20.26516180
131EGFR0.26135527
132CSF1R0.26043287
133MAP3K10.24268090
134CDK60.23863911
135LYN0.22067506
136NTRK30.21936514
137STK30.21795815
138PRKACG0.21568402
139DAPK10.21565197
140ERBB30.21426480
141PRKCZ0.21402995
142INSR0.21176361
143MAPK40.20400977
144GRK60.19114141
145BTK0.18580995
146IRAK30.17393051

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000618.71027661
2Caffeine metabolism_Homo sapiens_hsa002328.62855534
3Galactose metabolism_Homo sapiens_hsa000523.20910525
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.10495111
5Fatty acid metabolism_Homo sapiens_hsa012122.54882117
6Propanoate metabolism_Homo sapiens_hsa006402.23074824
7PPAR signaling pathway_Homo sapiens_hsa033202.19154524
8Pyruvate metabolism_Homo sapiens_hsa006202.02104364
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65579454
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59502794
11Cyanoamino acid metabolism_Homo sapiens_hsa004601.52174084
12Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.49520929
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27752786
14Fatty acid elongation_Homo sapiens_hsa000621.22600939
15* Prolactin signaling pathway_Homo sapiens_hsa049171.19689476
16Fatty acid degradation_Homo sapiens_hsa000711.12211694
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.10656339
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05080659
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03258527
20N-Glycan biosynthesis_Homo sapiens_hsa005100.99573967
21Fat digestion and absorption_Homo sapiens_hsa049750.92851700
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91835691
23Insulin resistance_Homo sapiens_hsa049310.89268129
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84538062
25AMPK signaling pathway_Homo sapiens_hsa041520.83528500
26Steroid biosynthesis_Homo sapiens_hsa001000.82128718
27Carbon metabolism_Homo sapiens_hsa012000.80238960
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78419215
29Protein export_Homo sapiens_hsa030600.71189626
30Pentose phosphate pathway_Homo sapiens_hsa000300.71095019
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69299629
32Glycerolipid metabolism_Homo sapiens_hsa005610.68491470
33Peroxisome_Homo sapiens_hsa041460.68046166
34Drug metabolism - other enzymes_Homo sapiens_hsa009830.62832984
35Histidine metabolism_Homo sapiens_hsa003400.61413501
36beta-Alanine metabolism_Homo sapiens_hsa004100.61295033
37Toxoplasmosis_Homo sapiens_hsa051450.60093006
38Amoebiasis_Homo sapiens_hsa051460.58521546
39Sulfur relay system_Homo sapiens_hsa041220.55902062
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52301282
41Hepatitis C_Homo sapiens_hsa051600.51478906
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.49585882
43Arginine biosynthesis_Homo sapiens_hsa002200.48668958
44Folate biosynthesis_Homo sapiens_hsa007900.48447063
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47200634
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46976085
47ECM-receptor interaction_Homo sapiens_hsa045120.46843819
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.45639740
49Vitamin digestion and absorption_Homo sapiens_hsa049770.44444846
50Pancreatic cancer_Homo sapiens_hsa052120.44125980
51Chronic myeloid leukemia_Homo sapiens_hsa052200.43734153
52Malaria_Homo sapiens_hsa051440.43236208
53Insulin signaling pathway_Homo sapiens_hsa049100.42752202
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42025713
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.42023838
56Tight junction_Homo sapiens_hsa045300.41523628
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41353939
58Acute myeloid leukemia_Homo sapiens_hsa052210.41333319
59Fructose and mannose metabolism_Homo sapiens_hsa000510.39515542
60Ether lipid metabolism_Homo sapiens_hsa005650.38851015
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38325300
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38076331
63Focal adhesion_Homo sapiens_hsa045100.37808857
64Legionellosis_Homo sapiens_hsa051340.36556756
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36488868
66Starch and sucrose metabolism_Homo sapiens_hsa005000.35873001
67Rheumatoid arthritis_Homo sapiens_hsa053230.34294169
68Small cell lung cancer_Homo sapiens_hsa052220.34053156
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33793412
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33437265
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33254012
72Endocytosis_Homo sapiens_hsa041440.32882548
73Butanoate metabolism_Homo sapiens_hsa006500.31992134
74Leishmaniasis_Homo sapiens_hsa051400.31924271
75Pancreatic secretion_Homo sapiens_hsa049720.31857862
76Biosynthesis of amino acids_Homo sapiens_hsa012300.31766818
77Glucagon signaling pathway_Homo sapiens_hsa049220.31632962
78Bile secretion_Homo sapiens_hsa049760.30492644
79Gastric acid secretion_Homo sapiens_hsa049710.30341461
80VEGF signaling pathway_Homo sapiens_hsa043700.30268693
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29298029
82Vibrio cholerae infection_Homo sapiens_hsa051100.29291578
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29127485
84Bladder cancer_Homo sapiens_hsa052190.29008596
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.28791742
86Arginine and proline metabolism_Homo sapiens_hsa003300.28601619
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28571325
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28076191
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27364019
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26891414
91Sulfur metabolism_Homo sapiens_hsa009200.26397934
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25763517
93Purine metabolism_Homo sapiens_hsa002300.24186481
94mTOR signaling pathway_Homo sapiens_hsa041500.24108630
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24014212
96Metabolic pathways_Homo sapiens_hsa011000.23700257
97Lysosome_Homo sapiens_hsa041420.23039820
98Osteoclast differentiation_Homo sapiens_hsa043800.22259950
99Proteoglycans in cancer_Homo sapiens_hsa052050.20546559
100Thyroid cancer_Homo sapiens_hsa052160.20278706
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.20058068
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19742411
103Collecting duct acid secretion_Homo sapiens_hsa049660.19448339
104Phagosome_Homo sapiens_hsa041450.19411592
105Renal cell carcinoma_Homo sapiens_hsa052110.17929985
106Hepatitis B_Homo sapiens_hsa051610.17333922
107Adherens junction_Homo sapiens_hsa045200.16690895
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16640629
109HIF-1 signaling pathway_Homo sapiens_hsa040660.16532098
110Tuberculosis_Homo sapiens_hsa051520.16531952
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16418133
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15651403
113TNF signaling pathway_Homo sapiens_hsa046680.15345096
114Colorectal cancer_Homo sapiens_hsa052100.15019492
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.14728823
116Glutathione metabolism_Homo sapiens_hsa004800.13788850
117One carbon pool by folate_Homo sapiens_hsa006700.13725815
118Salivary secretion_Homo sapiens_hsa049700.13115067
119Linoleic acid metabolism_Homo sapiens_hsa005910.12763685
120Nitrogen metabolism_Homo sapiens_hsa009100.12665845
121Mineral absorption_Homo sapiens_hsa049780.12569468
122Pertussis_Homo sapiens_hsa051330.11631404
123Tryptophan metabolism_Homo sapiens_hsa003800.11210247
124Renin secretion_Homo sapiens_hsa049240.09974783
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.09316726
126Arachidonic acid metabolism_Homo sapiens_hsa005900.03485989
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.02719098
128Vitamin B6 metabolism_Homo sapiens_hsa007500.02496289
129Ovarian steroidogenesis_Homo sapiens_hsa049130.02328134
130Endometrial cancer_Homo sapiens_hsa052130.01853028
131Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0696471
132Choline metabolism in cancer_Homo sapiens_hsa05231-0.0651248
133Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0486000
134Estrogen signaling pathway_Homo sapiens_hsa04915-0.0375522
135Cholinergic synapse_Homo sapiens_hsa04725-0.0352382
136Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0237320
137GnRH signaling pathway_Homo sapiens_hsa04912-0.0180995

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