CSN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of execution phase of apoptosis (GO:1900118)8.59964349
2oligosaccharide biosynthetic process (GO:0009312)8.55109317
3intestinal cholesterol absorption (GO:0030299)8.14675769
4type B pancreatic cell proliferation (GO:0044342)7.37331058
5cholesterol catabolic process (GO:0006707)6.65595114
6sterol catabolic process (GO:0016127)6.65595114
7regulation of vascular endothelial growth factor signaling pathway (GO:1900746)6.59490722
8valine metabolic process (GO:0006573)6.56468148
9segment specification (GO:0007379)6.49237449
10regulation of phospholipid biosynthetic process (GO:0071071)6.35317531
11phospholipid homeostasis (GO:0055091)6.30593114
12positive regulation of lipid storage (GO:0010884)6.13636486
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)6.08931627
14fatty-acyl-CoA biosynthetic process (GO:0046949)5.78165667
15long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.77060927
16positive regulation of p38MAPK cascade (GO:1900745)5.72539797
17intestinal absorption (GO:0050892)5.69175250
18pyrimidine-containing compound transmembrane transport (GO:0072531)5.60472911
19thioester biosynthetic process (GO:0035384)5.54868258
20acyl-CoA biosynthetic process (GO:0071616)5.54868258
21growth hormone receptor signaling pathway (GO:0060396)5.52761378
22mammary gland epithelial cell differentiation (GO:0060644)5.47316162
23ectoderm development (GO:0007398)5.46579553
24ceramide catabolic process (GO:0046514)5.42306612
25nucleoside transmembrane transport (GO:1901642)5.33100657
26regulation of sequestering of triglyceride (GO:0010889)5.23008170
27negative regulation of protein kinase B signaling (GO:0051898)5.20966239
28mitochondrial calcium ion transport (GO:0006851)5.02981130
29positive regulation of osteoblast proliferation (GO:0033690)4.96471845
30negative regulation of smooth muscle cell migration (GO:0014912)4.95505013
31phagocytosis, recognition (GO:0006910)4.93509687
32positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.90341346
33alpha-linolenic acid metabolic process (GO:0036109)4.89498376
34hemidesmosome assembly (GO:0031581)4.82880623
35negative regulation of endothelial cell proliferation (GO:0001937)4.73837093
36cellular response to growth hormone stimulus (GO:0071378)4.69360366
37embryonic process involved in female pregnancy (GO:0060136)4.59165866
38regulation of triglyceride biosynthetic process (GO:0010866)4.58561066
39* lactation (GO:0007595)4.44866921
40oligosaccharide metabolic process (GO:0009311)4.35420418
41regulation of apoptotic cell clearance (GO:2000425)4.35209228
42GDP-mannose metabolic process (GO:0019673)4.33774440
43* secretion by tissue (GO:0032941)4.33127058
44positive regulation of triglyceride metabolic process (GO:0090208)4.30047938
45long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.29927109
46positive regulation of histone deacetylation (GO:0031065)4.24807497
47regulation of p38MAPK cascade (GO:1900744)4.22516013
48fatty acid transmembrane transport (GO:1902001)4.22302071
49positive regulation of triglyceride biosynthetic process (GO:0010867)4.19261662
50response to host immune response (GO:0052572)4.12882291
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.12882291
52linoleic acid metabolic process (GO:0043651)4.12597552
53nucleoside transport (GO:0015858)4.09439957
54tooth mineralization (GO:0034505)4.06214431
55regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.04488002
56CDP-diacylglycerol biosynthetic process (GO:0016024)4.03903943
57fatty-acyl-CoA metabolic process (GO:0035337)3.98162067
58regulation of triglyceride metabolic process (GO:0090207)3.97041790
59tricarboxylic acid metabolic process (GO:0072350)3.96880680
60transcytosis (GO:0045056)3.92332498
61positive regulation of reactive oxygen species metabolic process (GO:2000379)3.87607592
62regulation of macrophage cytokine production (GO:0010935)3.87276962
63carnitine shuttle (GO:0006853)3.86484708
64biotin metabolic process (GO:0006768)3.85763707
65negative regulation of lipid catabolic process (GO:0050995)3.81996686
66glutathione biosynthetic process (GO:0006750)3.79720062
67negative regulation of epithelial cell differentiation (GO:0030857)3.76210610
68COPI coating of Golgi vesicle (GO:0048205)3.74607943
69Golgi transport vesicle coating (GO:0048200)3.74607943
70proximal/distal pattern formation (GO:0009954)3.73396133
71CDP-diacylglycerol metabolic process (GO:0046341)3.69253442
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.66399252
73response to host (GO:0075136)3.66399252
74response to host defenses (GO:0052200)3.66399252
75nucleotide-sugar biosynthetic process (GO:0009226)3.64253055
76O-glycan processing (GO:0016266)3.60829102
77positive regulation of toll-like receptor signaling pathway (GO:0034123)3.60188250
78* body fluid secretion (GO:0007589)3.59946246
79nonribosomal peptide biosynthetic process (GO:0019184)3.58479883
80regulation of clathrin-mediated endocytosis (GO:2000369)3.58019203
81low-density lipoprotein particle clearance (GO:0034383)3.56326512
82galactose metabolic process (GO:0006012)3.54690889
83interferon-gamma secretion (GO:0072643)3.54397016
84negative regulation of fatty acid transport (GO:2000192)3.53618107
85cellular carbohydrate biosynthetic process (GO:0034637)3.53347547
86positive regulation of macrophage cytokine production (GO:0060907)3.49458132
87regulation of execution phase of apoptosis (GO:1900117)3.46847763
88N-acetylneuraminate metabolic process (GO:0006054)3.46724296
89regulation of vasculogenesis (GO:2001212)3.39570869
90acetyl-CoA metabolic process (GO:0006084)3.39553657
91regulation of apoptotic process involved in morphogenesis (GO:1902337)3.38811838
92keratinocyte development (GO:0003334)3.33324585
93positive regulation of triglyceride lipase activity (GO:0061365)3.29314667
94positive regulation of lipoprotein lipase activity (GO:0051006)3.29314667
95positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.29186548
96sphingolipid catabolic process (GO:0030149)3.27370695
97positive regulation of chemokine secretion (GO:0090197)3.25604001
98negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.25483884
99mitochondrion distribution (GO:0048311)3.24325901
100purine nucleobase metabolic process (GO:0006144)3.23880136
101branched-chain amino acid metabolic process (GO:0009081)3.23812061
102temperature homeostasis (GO:0001659)3.21385141
103nucleobase catabolic process (GO:0046113)3.19795702
104lipid storage (GO:0019915)3.14056380
105branched-chain amino acid catabolic process (GO:0009083)3.13317055
106regulation of fatty acid oxidation (GO:0046320)3.11281079
107polarized epithelial cell differentiation (GO:0030859)3.10146486
108regulation of endothelial cell differentiation (GO:0045601)3.06833831
109response to phenylpropanoid (GO:0080184)3.06126538
110steroid catabolic process (GO:0006706)3.05979525
111triglyceride biosynthetic process (GO:0019432)3.04232141
112desmosome organization (GO:0002934)3.02465238
113positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.01014961
114regulation of lipid storage (GO:0010883)3.00154156
115insulin-like growth factor receptor signaling pathway (GO:0048009)2.99459291
116response to progesterone (GO:0032570)2.99379158
117response to food (GO:0032094)2.96468412
118iron coordination entity transport (GO:1901678)2.91944402
119membrane lipid catabolic process (GO:0046466)2.91730694
120cellular response to vitamin D (GO:0071305)2.91552418
121neutral lipid biosynthetic process (GO:0046460)2.90355012
122acylglycerol biosynthetic process (GO:0046463)2.90355012
123regulation of chemokine secretion (GO:0090196)2.90309086
124negative regulation of cell fate commitment (GO:0010454)2.88586133
125regulation of cholesterol storage (GO:0010885)2.87859504
126localization within membrane (GO:0051668)2.87812256
127mammary gland development (GO:0030879)2.86196352
128negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.85570736
129regulation of penile erection (GO:0060405)2.85565755
130regulation of histone deacetylation (GO:0031063)2.85345812
131long-chain fatty acid transport (GO:0015909)2.83872062
132angiogenesis involved in wound healing (GO:0060055)2.83694417
133adhesion of symbiont to host (GO:0044406)2.83075958
134positive regulation of SMAD protein import into nucleus (GO:0060391)2.81844253
135negative regulation of keratinocyte proliferation (GO:0010839)2.81054379
136regulation of SMAD protein import into nucleus (GO:0060390)2.81006626
137L-serine transport (GO:0015825)2.80298198
138folic acid transport (GO:0015884)2.77111800
139renal system development (GO:0072001)2.77073826
140fatty acid transport (GO:0015908)2.76799391
141negative regulation of lipid storage (GO:0010888)2.76488030
142short-chain fatty acid metabolic process (GO:0046459)2.76216019
143detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.76134936
144detection of molecule of bacterial origin (GO:0032490)2.75781617
145carnitine transmembrane transport (GO:1902603)2.75346440
146bundle of His cell to Purkinje myocyte communication (GO:0086069)2.74659972
147epithelial cell differentiation involved in prostate gland development (GO:0060742)2.74393967
148pentose-phosphate shunt (GO:0006098)2.73842739
149triglyceride catabolic process (GO:0019433)2.73781858
150regulation of cholesterol biosynthetic process (GO:0045540)2.73570496
151positive regulation of protein deacetylation (GO:0090312)2.72856594
152coenzyme A biosynthetic process (GO:0015937)2.71151980
153acrosome assembly (GO:0001675)2.69310151
154regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.66545454
155coenzyme A metabolic process (GO:0015936)2.65810867
156nucleoside diphosphate biosynthetic process (GO:0009133)2.61466285
157negative regulation of leukocyte migration (GO:0002686)2.56490964
158peptide biosynthetic process (GO:0043043)2.56471263
159pantothenate metabolic process (GO:0015939)2.48625538
160triglyceride metabolic process (GO:0006641)2.46355607
161ether lipid metabolic process (GO:0046485)2.46206913
162digestive system process (GO:0022600)2.45842562
163one-carbon metabolic process (GO:0006730)2.43595766
164positive regulation of macrophage activation (GO:0043032)2.41157907
165pattern specification involved in kidney development (GO:0061004)11.4042931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.02482514
2* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse5.45794006
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.54639912
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.41207136
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.29657996
6ZNF263_19887448_ChIP-Seq_K562_Human4.25554713
7ESR2_21235772_ChIP-Seq_MCF-7_Human4.07846602
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.15308492
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.03012856
10CLOCK_20551151_ChIP-Seq_293T_Human2.99092523
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.92536230
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.86062379
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58382522
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.46598677
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.17784125
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.17105279
17AR_21572438_ChIP-Seq_LNCaP_Human2.10417135
18PPAR_26484153_Chip-Seq_NCI-H1993_Human2.06101185
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02039674
20SRY_22984422_ChIP-ChIP_TESTIS_Rat1.99382570
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89668629
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.84710530
23* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.84345133
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83503094
25FLI1_21867929_ChIP-Seq_CD8_Mouse1.83014446
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.81712274
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81604100
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.77317336
29SOX2_20726797_ChIP-Seq_SW620_Human1.76353294
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73954305
31SOX9_24532713_ChIP-Seq_HFSC_Mouse1.73952698
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68291105
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64846377
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64583345
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62838973
36RACK7_27058665_Chip-Seq_MCF-7_Human1.60737122
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60373480
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.59879351
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58537586
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.57397420
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55658652
42PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.52126791
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.51894326
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50661493
45HTT_18923047_ChIP-ChIP_STHdh_Human1.49308638
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48466560
47AHR_22903824_ChIP-Seq_MCF-7_Human1.47008187
48SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.46999389
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45764999
50CTCF_26484167_Chip-Seq_Bcells_Mouse1.44469086
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44089054
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.43064837
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40879427
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39870713
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39825349
56FOXA1_25552417_ChIP-Seq_VCAP_Human1.38683866
57PU.1_20513432_ChIP-Seq_Bcells_Mouse1.37443751
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36746168
59STAT1_20625510_ChIP-Seq_HELA_Human1.32976338
60KLF5_25053715_ChIP-Seq_YYC3_Human1.30526662
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30139658
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29195968
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28822866
64PU_27001747_Chip-Seq_BMDM_Mouse1.28580177
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26681230
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.26621701
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25149133
68LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.22453676
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21861969
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20569115
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.20301676
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.19858496
73CJUN_26792858_Chip-Seq_BT549_Human1.19848419
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18174272
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18174272
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17633329
77GATA1_22025678_ChIP-Seq_K562_Human1.17573811
78GATA4_25053715_ChIP-Seq_YYC3_Human1.17221753
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17102085
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.16729599
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16041533
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15311245
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.13329625
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.13329625
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12116582
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11337145
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11227955
88GATA3_24758297_ChIP-Seq_MCF-7_Human1.10701937
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10600155
90* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06004798
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05808619
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05795797
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05485923
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05310956
95ATF3_27146783_Chip-Seq_COLON_Human1.04376710
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03948945
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03858053
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03326113
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02943716
100PU1_27457419_Chip-Seq_LIVER_Mouse1.01851715
101RXR_22108803_ChIP-Seq_LS180_Human1.01356853
102LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01115638
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01044830
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97984876
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96690340
106EP300_21415370_ChIP-Seq_HL-1_Mouse0.96444359
107KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94947794
108MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94116776
109SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93684472
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93667594
111SMC4_20622854_ChIP-Seq_HELA_Human0.93621182
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.92619500
113LXR_22292898_ChIP-Seq_THP-1_Human0.91731873
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91300103
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.90678420
116GATA6_25053715_ChIP-Seq_YYC3_Human0.89773523
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88635553
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.87510327
119STAT1_17558387_ChIP-Seq_HELA_Human0.86935533
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86775574
121FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86460704
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86429924
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86279619
124KDM2B_26808549_Chip-Seq_K562_Human0.85754743
125STAT3_18555785_Chip-Seq_ESCs_Mouse0.85309085
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84723958
127CBP_21632823_ChIP-Seq_H3396_Human0.84713257
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84634841
129TP63_23658742_ChIP-Seq_EP156T_Human0.84505166
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84333118
131TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84284293
132GATA2_19941826_ChIP-Seq_K562_Human0.83872426
133TP53_18474530_ChIP-ChIP_U2OS_Human0.83733446
134STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.83698025
135P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82682040
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82396991
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81386534
138CHD1_26751641_Chip-Seq_LNCaP_Human0.81354755
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.81098723
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80672486
141NFYA_21822215_ChIP-Seq_K562_Human0.80599720
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.80326643
143SA1_27219007_Chip-Seq_ERYTHROID_Human0.80244308
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79718381
145CBX2_22325352_ChIP-Seq_293T-Rex_Human0.79275551
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79250881
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78991434
148VDR_24787735_ChIP-Seq_THP-1_Human0.78472124
149VDR_24763502_ChIP-Seq_THP-1_Human0.77343207
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76480887
151CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76412929
152SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75285044
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75272492
154POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75142369
155FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74646631
156ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74038925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001881_abnormal_mammary_gland9.67426722
2MP0010234_abnormal_vibrissa_follicle5.91917705
3MP0002254_reproductive_system_inflammat4.30186686
4MP0000627_abnormal_mammary_gland3.43489611
5MP0003300_gastrointestinal_ulcer3.33335911
6MP0004264_abnormal_extraembryonic_tissu2.72311769
7MP0004019_abnormal_vitamin_homeostasis2.58001667
8MP0005670_abnormal_white_adipose2.52426117
9MP0003303_peritoneal_inflammation2.46506647
10MP0004130_abnormal_muscle_cell2.46050116
11MP0002796_impaired_skin_barrier2.21643306
12MP0003136_yellow_coat_color2.13608973
13MP0005666_abnormal_adipose_tissue2.13566919
14MP0003705_abnormal_hypodermis_morpholog2.11892614
15MP0003959_abnormal_lean_body2.05008832
16MP0005171_absent_coat_pigmentation1.95554158
17MP0005076_abnormal_cell_differentiation1.91893934
18MP0003011_delayed_dark_adaptation1.91424821
19MP0005083_abnormal_biliary_tract1.90052983
20MP0002098_abnormal_vibrissa_morphology1.81269563
21MP0004147_increased_porphyrin_level1.80284364
22MP0003566_abnormal_cell_adhesion1.79546732
23MP0004272_abnormal_basement_membrane1.75781790
24MP0001849_ear_inflammation1.74082357
25MP0005375_adipose_tissue_phenotype1.70217785
26MP0004043_abnormal_pH_regulation1.69308243
27MP0004185_abnormal_adipocyte_glucose1.60637296
28MP0005645_abnormal_hypothalamus_physiol1.59574708
29MP0005410_abnormal_fertilization1.54071100
30MP0010678_abnormal_skin_adnexa1.50968281
31MP0009278_abnormal_bone_marrow1.50765073
32MP0001873_stomach_inflammation1.44784568
33MP0010352_gastrointestinal_tract_polyps1.44307338
34MP0003045_fibrosis1.43563084
35MP0002282_abnormal_trachea_morphology1.36782136
36MP0005058_abnormal_lysosome_morphology1.35746058
37MP0005636_abnormal_mineral_homeostasis1.34459705
38MP0000377_abnormal_hair_follicle1.33743845
39MP0005501_abnormal_skin_physiology1.31931254
40MP0003453_abnormal_keratinocyte_physiol1.25047071
41MP0005275_abnormal_skin_tensile1.24661319
42MP0008004_abnormal_stomach_pH1.22025709
43MP0000678_abnormal_parathyroid_gland1.19684486
44MP0005452_abnormal_adipose_tissue1.17229052
45MP0004381_abnormal_hair_follicle1.14408844
46MP0000750_abnormal_muscle_regeneration1.14396936
47MP0000858_altered_metastatic_potential1.14045296
48MP0000003_abnormal_adipose_tissue1.13988435
49MP0003718_maternal_effect1.10047652
50MP0005332_abnormal_amino_acid1.09074846
51MP0004885_abnormal_endolymph1.08733516
52MP0002009_preneoplasia1.06410861
53MP0000013_abnormal_adipose_tissue1.04105710
54MP0010329_abnormal_lipoprotein_level1.04075348
55MP0003448_altered_tumor_morphology1.03532483
56MP0001879_abnormal_lymphatic_vessel1.03275647
57MP0002896_abnormal_bone_mineralization1.03207146
58MP0002060_abnormal_skin_morphology1.03184196
59MP0009764_decreased_sensitivity_to1.01941136
60MP0002118_abnormal_lipid_homeostasis0.99701220
61MP0008438_abnormal_cutaneous_collagen0.99272498
62MP0009384_cardiac_valve_regurgitation0.97524410
63MP0005023_abnormal_wound_healing0.97092199
64MP0001851_eye_inflammation0.96884758
65MP0005408_hypopigmentation0.95752261
66MP0005395_other_phenotype0.95529630
67MP0003936_abnormal_reproductive_system0.95485331
68MP0005360_urolithiasis0.95116045
69MP0002396_abnormal_hematopoietic_system0.94267274
70MP0001216_abnormal_epidermal_layer0.92464960
71MP0005448_abnormal_energy_balance0.87712947
72MP0002078_abnormal_glucose_homeostasis0.85971160
73MP0001348_abnormal_lacrimal_gland0.82996200
74MP0002168_other_aberrant_phenotype0.82944593
75MP0009765_abnormal_xenobiotic_induced0.81184891
76MP0003724_increased_susceptibility_to0.80873849
77MP0004947_skin_inflammation0.80760840
78MP0001663_abnormal_digestive_system0.79595634
79MP0005164_abnormal_response_to0.79095101
80MP0005085_abnormal_gallbladder_physiolo0.77907807
81MP0000579_abnormal_nail_morphology0.77145441
82MP0003075_altered_response_to0.77072258
83MP0001984_abnormal_olfaction0.76791499
84MP0005397_hematopoietic_system_phenotyp0.76769138
85MP0001545_abnormal_hematopoietic_system0.76769138
86MP0005365_abnormal_bile_salt0.75415847
87MP0008260_abnormal_autophagy0.75351058
88MP0001664_abnormal_digestion0.74897352
89MP0001177_atelectasis0.73888974
90MP0005535_abnormal_body_temperature0.73858129
91MP0005334_abnormal_fat_pad0.73649618
92MP0000566_synostosis0.73616865
93MP0001727_abnormal_embryo_implantation0.71777292
94MP0001765_abnormal_ion_homeostasis0.71424242
95MP0005220_abnormal_exocrine_pancreas0.70518513
96MP0008770_decreased_survivor_rate0.69191132
97MP0000490_abnormal_crypts_of0.69080607
98MP0000639_abnormal_adrenal_gland0.68705529
99MP0002970_abnormal_white_adipose0.67888465
100MP0001666_abnormal_nutrient_absorption0.67780456
101MP0003091_abnormal_cell_migration0.67383086
102MP0004924_abnormal_behavior0.65812663
103MP0005386_behavior/neurological_phenoty0.65812663
104MP0002971_abnormal_brown_adipose0.65318209
105MP0000613_abnormal_salivary_gland0.65196935
106MP0000609_abnormal_liver_physiology0.63596867
107MP0005381_digestive/alimentary_phenotyp0.63573566
108MP0000762_abnormal_tongue_morphology0.63420489
109MP0010771_integument_phenotype0.62046135
110MP0001533_abnormal_skeleton_physiology0.61776088
111MP0003172_abnormal_lysosome_physiology0.60945612
112MP0009379_abnormal_foot_pigmentation0.60627177
113MP0002877_abnormal_melanocyte_morpholog0.60440076
114MP0001346_abnormal_lacrimal_gland0.60347476
115MP0005165_increased_susceptibility_to0.59931984
116MP0003690_abnormal_glial_cell0.59657651
117MP0006054_spinal_hemorrhage0.58558771
118MP0009643_abnormal_urine_homeostasis0.57796034
119MP0009931_abnormal_skin_appearance0.56723053
120MP0004858_abnormal_nervous_system0.56720868
121MP0009115_abnormal_fat_cell0.55735741
122MP0003948_abnormal_gas_homeostasis0.54933399
123MP0005248_abnormal_Harderian_gland0.54928932
124MP0005584_abnormal_enzyme/coenzyme_acti0.53547578
125MP0002148_abnormal_hypersensitivity_rea0.51688175
126MP0002998_abnormal_bone_remodeling0.50977108
127MP0003953_abnormal_hormone_level0.49431971
128MP0009763_increased_sensitivity_to0.47030378
129MP0005385_cardiovascular_system_phenoty0.42454417
130MP0001544_abnormal_cardiovascular_syste0.42454417
131MP0000759_abnormal_skeletal_muscle0.42184977
132MP0009642_abnormal_blood_homeostasis0.41612197
133MP0002135_abnormal_kidney_morphology0.41451159
134MP0001756_abnormal_urination0.38246035
135MP0009785_altered_susceptibility_to0.36629027
136MP0000371_diluted_coat_color0.36423640
137MP0003195_calcinosis0.36392346
138MP0004782_abnormal_surfactant_physiolog0.31385055
139MP0008874_decreased_physiological_sensi0.31224450
140MP0008789_abnormal_olfactory_epithelium0.29116163
141MP0000343_altered_response_to0.28776509
142MP0005319_abnormal_enzyme/_coenzyme0.28189665
143MP0002419_abnormal_innate_immunity0.26925767
144MP0002693_abnormal_pancreas_physiology0.26401737
145MP0001542_abnormal_bone_strength0.26255922
146MP0001853_heart_inflammation0.25773044
147MP0001764_abnormal_homeostasis0.25554022
148MP0003638_abnormal_response/metabolism_0.25088452
149MP0002089_abnormal_postnatal_growth/wei0.25044497
150MP0005394_taste/olfaction_phenotype0.23592294
151MP0005499_abnormal_olfactory_system0.23592294
152MP0003879_abnormal_hair_cell0.23346801
153MP0000537_abnormal_urethra_morphology0.21682869
154MP0000598_abnormal_liver_morphology0.21291647

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.83194187
2Decreased circulating renin level (HP:0003351)6.74299042
3Renal salt wasting (HP:0000127)5.99600626
4Right ventricular cardiomyopathy (HP:0011663)5.72879846
5Pili torti (HP:0003777)5.07798073
6Tubulointerstitial nephritis (HP:0001970)5.03398660
7Hypokalemic alkalosis (HP:0001949)4.47695728
8Amelogenesis imperfecta (HP:0000705)4.40282878
9Epidermoid cyst (HP:0200040)4.35333528
10Atrophic scars (HP:0001075)4.28850925
11Curly hair (HP:0002212)4.18063154
12Milia (HP:0001056)4.17522154
13Abnormality of purine metabolism (HP:0004352)4.08217980
14Overgrowth (HP:0001548)4.02315450
15Congenital ichthyosiform erythroderma (HP:0007431)3.97951960
16Hyperkalemia (HP:0002153)3.94410089
17Hyperlipoproteinemia (HP:0010980)3.93398917
18Hydronephrosis (HP:0000126)3.81475877
19Myocardial infarction (HP:0001658)3.79048282
20Chronic bronchitis (HP:0004469)3.74696669
21Hyperaldosteronism (HP:0000859)3.71813728
22Hypoplasia of the iris (HP:0007676)3.69987188
23Onycholysis (HP:0001806)3.69918597
24Abnormality of the costochondral junction (HP:0000919)3.60559605
25Axonal loss (HP:0003447)3.50183051
26Skin nodule (HP:0200036)3.44258119
27Sparse lateral eyebrow (HP:0005338)3.36269617
28Symptomatic seizures (HP:0011145)3.35304185
29Thin bony cortex (HP:0002753)3.35139818
30Nephritis (HP:0000123)3.26979177
31Morphological abnormality of the inner ear (HP:0011390)3.26181690
32Aortic aneurysm (HP:0004942)3.22291050
33Hypotension (HP:0002615)3.18150966
34Aplasia cutis congenita (HP:0001057)3.15646476
35Ectropion (HP:0000656)3.15391227
36Subcapsular cataract (HP:0000523)3.15055578
37Abnormality of renin-angiotensin system (HP:0000847)3.14505927
38Shallow orbits (HP:0000586)3.13068480
39Abnormal hair laboratory examination (HP:0003328)3.11639331
40Enlarged epiphyses (HP:0010580)3.06704082
41Xanthomatosis (HP:0000991)3.06111913
42Metaphyseal irregularity (HP:0003025)3.04430984
43Hyponatremia (HP:0002902)3.00546758
44Fragile nails (HP:0001808)2.98912752
45Turricephaly (HP:0000262)2.93880228
46White forelock (HP:0002211)2.90550761
47Hypoplasia of dental enamel (HP:0006297)2.86241241
48Abnormal tarsal ossification (HP:0008369)2.82288285
49Gout (HP:0001997)2.81740987
50Abnormality of chloride homeostasis (HP:0011422)2.80796965
51Abnormality of the anterior chamber (HP:0000593)2.79778937
52Tubulointerstitial fibrosis (HP:0005576)2.76658297
53Glomerulosclerosis (HP:0000096)2.76200789
54Premature skin wrinkling (HP:0100678)2.75374649
55Abnormal auditory evoked potentials (HP:0006958)2.72173721
56Flat acetabular roof (HP:0003180)2.71672217
57Tubular atrophy (HP:0000092)2.67417019
58Abnormality of calcium-phosphate metabolism (HP:0100530)2.66180974
59Nausea (HP:0002018)2.61916121
60Delayed epiphyseal ossification (HP:0002663)2.58951723
61Urethral obstruction (HP:0000796)2.55485894
62Aortic dissection (HP:0002647)2.55113172
63Aneurysm (HP:0002617)2.51453298
64Cerebral aneurysm (HP:0004944)2.49951075
65Patchy hypopigmentation of hair (HP:0011365)2.49810173
66Protuberant abdomen (HP:0001538)2.47501023
67Abnormality of nail color (HP:0100643)2.46510679
68Enlarged penis (HP:0000040)2.44523753
69Abnormality of sodium homeostasis (HP:0010931)2.44191740
70Hemorrhage of the eye (HP:0011885)2.44012774
71Concave nail (HP:0001598)2.43470308
72Germ cell neoplasia (HP:0100728)2.41863190
73Peripheral hypomyelination (HP:0007182)2.41737778
74Stomach cancer (HP:0012126)2.40870009
75Abnormality of renal excretion (HP:0011036)2.38423629
76Loss of speech (HP:0002371)2.35533460
77Polar cataract (HP:0010696)2.34244082
78Biliary tract neoplasm (HP:0100574)2.33603979
79Increased purine levels (HP:0004368)2.33313622
80Hyperuricemia (HP:0002149)2.33313622
81Vascular calcification (HP:0004934)2.30685757
82Adrenal overactivity (HP:0002717)2.30002265
83Abnormality of nucleobase metabolism (HP:0010932)2.29454269
84Intrahepatic cholestasis (HP:0001406)2.29282082
85Abnormality of renal resorption (HP:0011038)2.28495210
86Cardiovascular calcification (HP:0011915)2.27921340
87Rickets (HP:0002748)2.24183499
88Nail dystrophy (HP:0008404)2.23913955
89Alkalosis (HP:0001948)2.22537144
90Interstitial pulmonary disease (HP:0006530)2.16448671
91Arterial tortuosity (HP:0005116)2.15899663
92Abnormality of liposaccharide metabolism (HP:0010968)2.14907426
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.14907426
94Abnormality of glycolipid metabolism (HP:0010969)2.14907426
95Renal tubular acidosis (HP:0001947)2.14699795
96Glomerulonephritis (HP:0000099)2.14435701
97Abdominal distention (HP:0003270)2.13686975
98Abnormality of the proximal phalanges of the hand (HP:0009834)2.13073315
99Hepatosplenomegaly (HP:0001433)2.10488806
100Exostoses (HP:0100777)2.10337781
101Flat capital femoral epiphysis (HP:0003370)2.08256410
102Abnormal epiphyseal ossification (HP:0010656)2.07793767
103Optic neuritis (HP:0100653)2.07383543
104Retrobulbar optic neuritis (HP:0100654)2.07383543
105Heterochromia iridis (HP:0001100)2.07132366
106Anterior segment dysgenesis (HP:0007700)2.05997488
107Hyperglycinuria (HP:0003108)2.05974943
108Insulin-resistant diabetes mellitus (HP:0000831)2.05452088
109Azoospermia (HP:0000027)2.04455880
110Metabolic acidosis (HP:0001942)2.03849403
111Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03288025
112Nephrolithiasis (HP:0000787)2.02091203
113Elevated alkaline phosphatase (HP:0003155)2.01754695
114Hypercholesterolemia (HP:0003124)2.01672086
115Buphthalmos (HP:0000557)2.01346087
116Hyperglycinemia (HP:0002154)2.00724217
117Epiphyseal dysplasia (HP:0002656)1.98567608
118Vascular tortuosity (HP:0004948)1.97828551
119Abnormality of the periventricular white matter (HP:0002518)1.96719884
120Bronchomalacia (HP:0002780)1.95984441
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95359139
122Focal segmental glomerulosclerosis (HP:0000097)1.94513211
123Broad metatarsal (HP:0001783)1.93904752
124Hypokalemia (HP:0002900)1.93694900
125Orchitis (HP:0100796)1.92781082
126Hypoplasia of the pons (HP:0012110)1.92751019
127Osteolytic defects of the hand bones (HP:0009699)1.92015128
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.92015128
129Esophageal varix (HP:0002040)1.91887411
130Hypophosphatemia (HP:0002148)1.91866606
131Fragile skin (HP:0001030)1.91273067
132Stridor (HP:0010307)1.91260679
133Bone pain (HP:0002653)1.89863716
134Plantar hyperkeratosis (HP:0007556)1.89375474
135Bone cyst (HP:0012062)1.89052621
136Ependymoma (HP:0002888)1.88763152
137Dysostosis multiplex (HP:0000943)1.88722576
138Spastic tetraparesis (HP:0001285)1.88378011
139Vacuolated lymphocytes (HP:0001922)1.88287813
140Abnormality of the dental pulp (HP:0006479)1.87211895
141Hyperparathyroidism (HP:0000843)1.85320731
142Tetraparesis (HP:0002273)1.85071337
143Increased cerebral lipofuscin (HP:0011813)1.84870384
144Asymmetric septal hypertrophy (HP:0001670)1.84285100
145Paraparesis (HP:0002385)1.83825194
146Ketosis (HP:0001946)1.81374417
147Abnormality of cochlea (HP:0000375)1.81333065
148Blue sclerae (HP:0000592)1.80352499
149Abnormal enzyme/coenzyme activity (HP:0012379)1.79940492
150Alacrima (HP:0000522)1.79902515
151Blepharitis (HP:0000498)1.79119365
152Long toe (HP:0010511)1.78550888
153Widely patent fontanelles and sutures (HP:0004492)1.77591888
154Abnormality of serine family amino acid metabolism (HP:0010894)1.76049842
155Abnormality of glycine metabolism (HP:0010895)1.76049842
156Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75897399
157Ketoacidosis (HP:0001993)1.75374735
158Congenital glaucoma (HP:0001087)1.75277433
159Epiphyseal stippling (HP:0010655)1.75022232
160Pancreatitis (HP:0001733)1.73783925
161Abnormality of alkaline phosphatase activity (HP:0004379)1.73308197
162Advanced eruption of teeth (HP:0006288)1.72750555
163Woolly hair (HP:0002224)1.70647603
164Abnormality of transition element cation homeostasis (HP:0011030)1.67665500
165Alopecia of scalp (HP:0002293)1.67006667
166Micronodular cirrhosis (HP:0001413)1.66059371
167Ankle contracture (HP:0006466)1.65680707
168Primary adrenal insufficiency (HP:0008207)1.65210441
169Abnormality of aromatic amino acid family metabolism (HP:0004338)1.65178292
170Abnormality of the nasal septum (HP:0000419)1.64973288
171Ureteral stenosis (HP:0000071)1.64838309
172Flat occiput (HP:0005469)1.64369016
173Abnormality of the renal cortex (HP:0011035)1.62917473
174Abnormality of fatty-acid metabolism (HP:0004359)1.62414094
175Systemic lupus erythematosus (HP:0002725)1.60446271
176Opisthotonus (HP:0002179)1.59883610
177Genu varum (HP:0002970)1.59294764
178Reduced antithrombin III activity (HP:0001976)1.58744881
179Neurodegeneration (HP:0002180)1.55871868
180Tubulointerstitial abnormality (HP:0001969)1.54631254
181Dehydration (HP:0001944)1.54287538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK17.99999928
2CAMK1D3.87632683
3NME23.66478675
4CAMK1G3.24318254
5PKN23.18918553
6MATK2.95652006
7ICK2.86923943
8MAP2K62.79003523
9EPHA32.78917132
10EPHA22.77494197
11EPHB12.75300213
12ERN12.63001541
13PIK3CA2.62932462
14TRIB32.57059866
15EEF2K2.50288669
16ARAF2.37414370
17PTK62.06336420
18LATS12.06218488
19RIPK11.95379045
20FER1.92722032
21PDK21.74312115
22STK391.68963202
23MAP3K91.66952770
24WNK41.66311428
25BMPR21.60538924
26DAPK21.39242064
27RET1.38704000
28PDK41.38632207
29PDK31.38632207
30TGFBR21.35571607
31BMX1.31076766
32MOS1.28840130
33PDGFRB1.27420014
34KSR21.26893989
35FGFR41.25806184
36SCYL21.25114397
37MAP3K131.20944371
38MAPKAPK31.20023762
39BRAF1.18400636
40BTK1.12464640
41BCKDK1.06062630
42MAP3K61.05593404
43LRRK20.99638023
44RPS6KB20.98772253
45STK160.93999365
46RIPK40.91681829
47MAP3K20.90586651
48STK380.90585120
49IRAK30.90221032
50PINK10.86121058
51TESK20.85572912
52NLK0.83987902
53MAP3K70.82200646
54SGK30.81240629
55STK38L0.81071681
56PTK20.79814686
57PDPK10.75796631
58CSNK2A20.74760268
59PRKAA20.74241333
60CAMK2D0.71491398
61MAP3K30.71174738
62LIMK10.70013333
63ERBB20.69953172
64RPS6KB10.69467725
65IRAK40.68299370
66JAK10.67664461
67ZAP700.66293172
68CDK90.64006108
69FGFR30.63665142
70CDK60.63630128
71PDK10.63134368
72MST40.62718491
73MYLK0.61851325
74TBK10.61201650
75CHUK0.61156971
76TRPM70.60954742
77PRKCD0.60767191
78CAMK2G0.60484405
79PIM10.59747445
80GRK70.59490263
81IRAK20.59253005
82GSK3A0.59066016
83JAK20.58925145
84MET0.58096793
85JAK30.57463163
86CAMK2B0.55347271
87ILK0.55117722
88SGK20.53532744
89SGK4940.53257277
90SGK2230.53257277
91FRK0.52376032
92TIE10.52284115
93MAP3K10.51594773
94PRKCG0.50865055
95GRK60.50846779
96TAOK20.50351433
97MAP2K20.49943979
98DDR20.49801641
99EIF2AK10.49229726
100CAMK10.48466360
101PAK20.48451570
102LATS20.47391670
103IGF1R0.45632025
104IKBKE0.44890793
105STK30.44885075
106TTN0.44870247
107WNK10.42809957
108TAOK30.42322030
109RPS6KA20.42011655
110MAPK120.40764164
111MTOR0.40520616
112PDGFRA0.40084589
113PRKD10.38899703
114IRAK10.38572816
115BCR0.37560577
116TYK20.35963889
117EIF2AK30.34711854
118FGFR10.32808597
119NEK60.31933967
120PAK40.30981632
121MAPKAPK50.29701312
122MST1R0.29462822
123EPHB20.29082464
124EGFR0.28024540
125FGR0.27802181
126LYN0.27343839
127NTRK30.26723281
128DYRK20.26423813
129DAPK30.25902248
130TESK10.25278960
131MAP3K140.24751444
132INSR0.24074845
133CSNK1A10.23626202
134SRC0.22815440
135HIPK20.22753151
136PRKAA10.22658753
137PIK3CG0.21192235
138EIF2AK20.19811892
139CSF1R0.19294627
140MAP2K10.19269312
141RPS6KA10.19207446
142LMTK20.19020993
143KIT0.18240287
144NEK90.15146774
145FLT30.15040222
146PAK30.14592889
147RPS6KL10.14592489
148RPS6KC10.14592489
149TAOK10.14428252

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000618.21572304
2Caffeine metabolism_Homo sapiens_hsa002327.91162247
3Galactose metabolism_Homo sapiens_hsa000522.92300518
4Prolactin signaling pathway_Homo sapiens_hsa049172.33827513
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33602528
6Fatty acid metabolism_Homo sapiens_hsa012122.16022168
7PPAR signaling pathway_Homo sapiens_hsa033201.72402823
8Propanoate metabolism_Homo sapiens_hsa006401.64775382
9Pyruvate metabolism_Homo sapiens_hsa006201.55884443
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.48355469
11Nitrogen metabolism_Homo sapiens_hsa009101.43716235
12Adherens junction_Homo sapiens_hsa045201.27790783
13Insulin resistance_Homo sapiens_hsa049311.25714717
14Pancreatic cancer_Homo sapiens_hsa052121.23942795
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22274747
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20313251
17Bladder cancer_Homo sapiens_hsa052191.19630337
18ECM-receptor interaction_Homo sapiens_hsa045121.16778033
19Amoebiasis_Homo sapiens_hsa051461.13105684
20Collecting duct acid secretion_Homo sapiens_hsa049661.11695904
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10890777
22Toxoplasmosis_Homo sapiens_hsa051451.01584605
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.00304420
24AMPK signaling pathway_Homo sapiens_hsa041520.98175506
25Focal adhesion_Homo sapiens_hsa045100.95444293
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94674560
27Vibrio cholerae infection_Homo sapiens_hsa051100.94012049
28Chronic myeloid leukemia_Homo sapiens_hsa052200.93359622
29Small cell lung cancer_Homo sapiens_hsa052220.92176823
30Acute myeloid leukemia_Homo sapiens_hsa052210.91720480
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88887477
32Endometrial cancer_Homo sapiens_hsa052130.86944851
33Central carbon metabolism in cancer_Homo sapiens_hsa052300.84579692
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82838628
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82691917
36Proteoglycans in cancer_Homo sapiens_hsa052050.81979354
37Fatty acid degradation_Homo sapiens_hsa000710.81022796
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80660467
39N-Glycan biosynthesis_Homo sapiens_hsa005100.80619040
40Leukocyte transendothelial migration_Homo sapiens_hsa046700.80239619
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79888635
42Tight junction_Homo sapiens_hsa045300.78714453
43Rheumatoid arthritis_Homo sapiens_hsa053230.72029219
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70809994
45Hepatitis C_Homo sapiens_hsa051600.68123718
46Renal cell carcinoma_Homo sapiens_hsa052110.67467535
47Insulin signaling pathway_Homo sapiens_hsa049100.67277180
48Fatty acid elongation_Homo sapiens_hsa000620.66776837
49Pentose phosphate pathway_Homo sapiens_hsa000300.66663890
50Thyroid cancer_Homo sapiens_hsa052160.66153006
51Malaria_Homo sapiens_hsa051440.62869765
52Histidine metabolism_Homo sapiens_hsa003400.60822724
53beta-Alanine metabolism_Homo sapiens_hsa004100.60782301
54HIF-1 signaling pathway_Homo sapiens_hsa040660.59109060
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58854761
56Colorectal cancer_Homo sapiens_hsa052100.58018292
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56018116
58Steroid biosynthesis_Homo sapiens_hsa001000.55136205
59Non-small cell lung cancer_Homo sapiens_hsa052230.54045090
60Hippo signaling pathway_Homo sapiens_hsa043900.53193241
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52850865
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52024679
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51103382
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.50417451
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50183738
66mTOR signaling pathway_Homo sapiens_hsa041500.49966466
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49570560
68Prostate cancer_Homo sapiens_hsa052150.49270939
69Fat digestion and absorption_Homo sapiens_hsa049750.48494440
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46960909
71Hepatitis B_Homo sapiens_hsa051610.46900735
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46314386
73ErbB signaling pathway_Homo sapiens_hsa040120.45581318
74Leishmaniasis_Homo sapiens_hsa051400.45173355
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44815030
76Carbon metabolism_Homo sapiens_hsa012000.44487577
77Protein export_Homo sapiens_hsa030600.41279736
78Ether lipid metabolism_Homo sapiens_hsa005650.41134121
79VEGF signaling pathway_Homo sapiens_hsa043700.40827050
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38724334
81Fructose and mannose metabolism_Homo sapiens_hsa000510.37731461
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37406276
83Peroxisome_Homo sapiens_hsa041460.37169882
84Salmonella infection_Homo sapiens_hsa051320.36835539
85Pathways in cancer_Homo sapiens_hsa052000.35511525
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35400666
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35018793
88FoxO signaling pathway_Homo sapiens_hsa040680.34875253
89Legionellosis_Homo sapiens_hsa051340.34778214
90Starch and sucrose metabolism_Homo sapiens_hsa005000.34765320
91MicroRNAs in cancer_Homo sapiens_hsa052060.34607518
92TNF signaling pathway_Homo sapiens_hsa046680.34545530
93Endocytosis_Homo sapiens_hsa041440.33957440
94Phagosome_Homo sapiens_hsa041450.33899053
95Vitamin digestion and absorption_Homo sapiens_hsa049770.33111982
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.31146677
97Pancreatic secretion_Homo sapiens_hsa049720.30876176
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30475726
99Basal cell carcinoma_Homo sapiens_hsa052170.29563321
100Glycerolipid metabolism_Homo sapiens_hsa005610.29553537
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28694895
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28618695
103Osteoclast differentiation_Homo sapiens_hsa043800.28463755
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28319730
105Glucagon signaling pathway_Homo sapiens_hsa049220.27672691
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27660652
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27498675
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27198636
109Biosynthesis of amino acids_Homo sapiens_hsa012300.26955768
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.26250376
111Sulfur metabolism_Homo sapiens_hsa009200.26005169
112Arginine and proline metabolism_Homo sapiens_hsa003300.25800033
113Notch signaling pathway_Homo sapiens_hsa043300.25760142
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25242391
115Platelet activation_Homo sapiens_hsa046110.24966165
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24796741
117Dorso-ventral axis formation_Homo sapiens_hsa043200.23723093
118Melanoma_Homo sapiens_hsa052180.23156035
119Metabolic pathways_Homo sapiens_hsa011000.22549091
120Purine metabolism_Homo sapiens_hsa002300.22081016
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20380314
122Arginine biosynthesis_Homo sapiens_hsa002200.20145871
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.20064446
124Pertussis_Homo sapiens_hsa051330.19667485
125Sulfur relay system_Homo sapiens_hsa041220.19330237
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.15220576
127Linoleic acid metabolism_Homo sapiens_hsa005910.14019898
128Glutathione metabolism_Homo sapiens_hsa004800.13204403
129Salivary secretion_Homo sapiens_hsa049700.11975540
130Lysosome_Homo sapiens_hsa041420.11216622
131Folate biosynthesis_Homo sapiens_hsa007900.09750615
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.09694782
133One carbon pool by folate_Homo sapiens_hsa006700.09536684
134Butanoate metabolism_Homo sapiens_hsa006500.09363681
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07071837
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06406897
137Vitamin B6 metabolism_Homo sapiens_hsa007500.04336931
138Arachidonic acid metabolism_Homo sapiens_hsa005900.04121815
139Ovarian steroidogenesis_Homo sapiens_hsa049130.03260663
140Tryptophan metabolism_Homo sapiens_hsa003800.02428966
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.01906520
142Tuberculosis_Homo sapiens_hsa051520.00399534
143Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0545827
144Mineral absorption_Homo sapiens_hsa04978-0.0464012
145Estrogen signaling pathway_Homo sapiens_hsa04915-0.0380999
146Cholinergic synapse_Homo sapiens_hsa04725-0.0358894
147Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0275572
148Staphylococcus aureus infection_Homo sapiens_hsa05150-0.0263198
149GnRH signaling pathway_Homo sapiens_hsa04912-0.0170366
150Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0013437

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