CSNK1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.17582872
2keratinocyte development (GO:0003334)4.16852868
3positive regulation of protein autophosphorylation (GO:0031954)4.10711951
4lactate metabolic process (GO:0006089)4.08527743
5DNA double-strand break processing (GO:0000729)4.00206504
6water-soluble vitamin biosynthetic process (GO:0042364)3.84499542
7regulation of glucokinase activity (GO:0033131)3.59455903
8regulation of hexokinase activity (GO:1903299)3.59455903
9proteasome assembly (GO:0043248)3.53846180
10respiratory chain complex IV assembly (GO:0008535)3.33311069
11regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.29637936
12prenylation (GO:0097354)3.25912986
13protein prenylation (GO:0018342)3.25912986
14pre-miRNA processing (GO:0031054)3.25002583
15inositol phosphate catabolic process (GO:0071545)3.19662380
16mitotic sister chromatid cohesion (GO:0007064)3.15887512
17cytoplasmic mRNA processing body assembly (GO:0033962)3.15374557
18positive regulation of glycoprotein biosynthetic process (GO:0010560)3.12810491
19negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.05815335
20signal peptide processing (GO:0006465)3.05366237
21nuclear pore complex assembly (GO:0051292)3.03409584
22cullin deneddylation (GO:0010388)3.03049396
23positive regulation of glycolytic process (GO:0045821)3.00931029
24intraciliary transport (GO:0042073)2.99632540
25platelet dense granule organization (GO:0060155)2.99500336
26protein K6-linked ubiquitination (GO:0085020)2.97898469
27polarized epithelial cell differentiation (GO:0030859)2.96837883
28dorsal/ventral axis specification (GO:0009950)2.95740426
29kidney morphogenesis (GO:0060993)2.94383223
30regulation of meiosis I (GO:0060631)2.90001883
31regulation of Rac protein signal transduction (GO:0035020)2.88750915
32histone H2A acetylation (GO:0043968)2.86780044
33nuclear pore organization (GO:0006999)2.86604413
34zinc ion transport (GO:0006829)2.84602194
35mRNA stabilization (GO:0048255)2.84067676
36RNA stabilization (GO:0043489)2.84067676
37negative regulation of epidermis development (GO:0045683)2.81407052
38regulation of protein autophosphorylation (GO:0031952)2.80642275
39positive regulation of glycoprotein metabolic process (GO:1903020)2.80029950
40body morphogenesis (GO:0010171)2.79606901
41negative regulation of DNA-dependent DNA replication (GO:2000104)2.77769389
42hippo signaling (GO:0035329)2.75894222
43regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.75643470
44cytochrome complex assembly (GO:0017004)2.74494166
45regulation of telomere maintenance via telomerase (GO:0032210)2.74152577
46protein localization to cilium (GO:0061512)2.73096800
47lipid particle organization (GO:0034389)2.73063315
48regulation of protein glycosylation (GO:0060049)2.72108410
49NLS-bearing protein import into nucleus (GO:0006607)2.70894086
50protein K11-linked deubiquitination (GO:0035871)2.70797209
51cytoskeletal anchoring at plasma membrane (GO:0007016)2.70576898
52negative regulation of cell cycle G2/M phase transition (GO:1902750)2.70428687
53protein deneddylation (GO:0000338)2.68698578
54bone trabecula formation (GO:0060346)2.68284593
55histone H4-K5 acetylation (GO:0043981)2.68243432
56histone H4-K8 acetylation (GO:0043982)2.68243432
57polyol catabolic process (GO:0046174)2.67352546
58female gonad development (GO:0008585)2.67326435
59chromatin assembly (GO:0031497)2.67009707
60regulation of type B pancreatic cell apoptotic process (GO:2000674)2.66532133
61somite rostral/caudal axis specification (GO:0032525)2.66190364
62negative regulation of neurological system process (GO:0031645)2.64855269
63replication fork processing (GO:0031297)2.64571433
64presynaptic membrane assembly (GO:0097105)2.64521398
65branched-chain amino acid catabolic process (GO:0009083)2.63654720
66phosphorylated carbohydrate dephosphorylation (GO:0046838)2.63424762
67inositol phosphate dephosphorylation (GO:0046855)2.63424762
68response to X-ray (GO:0010165)2.63134866
69peptidyl-cysteine modification (GO:0018198)2.61047409
70desmosome organization (GO:0002934)2.60585169
71prostate gland growth (GO:0060736)2.58503425
72regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58420055
73mitochondrial DNA replication (GO:0006264)2.57911836
74positive regulation of actin filament depolymerization (GO:0030836)2.57530911
75UDP-N-acetylglucosamine metabolic process (GO:0006047)2.57057740
76heterochromatin organization (GO:0070828)2.56665605
77regulation of keratinocyte proliferation (GO:0010837)2.55752929
78limb bud formation (GO:0060174)2.54984732
79negative regulation of JUN kinase activity (GO:0043508)2.50872086
80intestinal epithelial cell development (GO:0060576)2.49234298
81notochord development (GO:0030903)2.48366057
82cilium morphogenesis (GO:0060271)2.48028984
83asymmetric protein localization (GO:0008105)2.47656315
84cell fate commitment involved in formation of primary germ layer (GO:0060795)2.46836282
85peptidyl-histidine modification (GO:0018202)2.46477989
86apical protein localization (GO:0045176)2.45221285
87somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.45121767
88somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.45121767
89isotype switching (GO:0045190)2.45121767
90synapsis (GO:0007129)2.44873316
91positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.42310536
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.42310536
93positive regulation of mitotic sister chromatid separation (GO:1901970)2.42310536
94sister chromatid segregation (GO:0000819)2.42022284
95regulation of sister chromatid cohesion (GO:0007063)2.41998277
96layer formation in cerebral cortex (GO:0021819)2.41129549
97positive regulation of histone deacetylation (GO:0031065)2.39974662
98DNA unwinding involved in DNA replication (GO:0006268)2.39727483
99histone H4-K16 acetylation (GO:0043984)2.39234889
100negative regulation of axon extension involved in axon guidance (GO:0048843)2.36950636
101maintenance of protein location in nucleus (GO:0051457)2.36235093
102inner ear receptor cell development (GO:0060119)2.35673282
103regulation of sulfur metabolic process (GO:0042762)2.35362419
104regulation of acyl-CoA biosynthetic process (GO:0050812)2.35187729
105COPII vesicle coating (GO:0048208)2.33210438
106stress granule assembly (GO:0034063)2.32373473
107establishment of nucleus localization (GO:0040023)2.31463168
108paraxial mesoderm development (GO:0048339)2.30738346
109anterior/posterior axis specification (GO:0009948)2.29351031
110protein localization to kinetochore (GO:0034501)2.29322540
111glucocorticoid receptor signaling pathway (GO:0042921)2.28804756
112negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.28537302
113Leydig cell differentiation (GO:0033327)2.28379516
114protein localization to endosome (GO:0036010)2.27588398
115regulation of response to osmotic stress (GO:0047484)2.26653003
116protein targeting to Golgi (GO:0000042)2.25928483
117transcytosis (GO:0045056)2.24703299
118negative regulation of cell fate commitment (GO:0010454)2.24102000
119regulation of RNA export from nucleus (GO:0046831)2.24098588
120positive regulation of macroautophagy (GO:0016239)2.22953661
121RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.22851578
122detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.22716244
123photoreceptor cell maintenance (GO:0045494)2.22374344
124dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.22167374
125positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.22085998
126COPI coating of Golgi vesicle (GO:0048205)2.22074227
127Golgi transport vesicle coating (GO:0048200)2.22074227
128mitotic chromosome condensation (GO:0007076)2.21629985
129atrial cardiac muscle cell action potential (GO:0086014)2.21321527
130negative regulation of histone methylation (GO:0031061)2.21193760
131parental behavior (GO:0060746)2.20957189
132glial cell proliferation (GO:0014009)2.20853989
133cilium organization (GO:0044782)2.20533251
134regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.20281921
135negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.20270879
136double-strand break repair via homologous recombination (GO:0000724)2.19709350
137insulin secretion (GO:0030073)2.19680482
138cilium assembly (GO:0042384)2.19368978
139recombinational repair (GO:0000725)2.18817993
140ribosome assembly (GO:0042255)2.18415723
141pancreas development (GO:0031016)2.18348833
142nucleotide transmembrane transport (GO:1901679)2.18325018
143hemidesmosome assembly (GO:0031581)2.18233401
144regulation of male gonad development (GO:2000018)2.18130242
145regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.17774874
146axoneme assembly (GO:0035082)2.17497887
147branching involved in mammary gland duct morphogenesis (GO:0060444)2.17391167
148establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.17335538
149regulation of mRNA stability (GO:0043488)2.17157729
150negative regulation of catenin import into nucleus (GO:0035414)2.16848687
151response to nitrosative stress (GO:0051409)2.16187820
152ectodermal placode formation (GO:0060788)2.16152412
153cellular ketone body metabolic process (GO:0046950)2.15824505
154single strand break repair (GO:0000012)2.15748663
155neural tube formation (GO:0001841)2.15461969
156regulation of DNA endoreduplication (GO:0032875)2.15398120
157regulation of hippo signaling (GO:0035330)2.14655094
158response to redox state (GO:0051775)2.14430195
159anterograde synaptic vesicle transport (GO:0048490)2.14196368
160nerve growth factor signaling pathway (GO:0038180)2.13233659
161muscle organ morphogenesis (GO:0048644)2.12604043
162trophectodermal cell differentiation (GO:0001829)2.12530273
163peptidyl-lysine dimethylation (GO:0018027)2.12302192
164embryonic body morphogenesis (GO:0010172)2.12123323
165regulation of catenin import into nucleus (GO:0035412)2.11909285
166planar cell polarity pathway involved in neural tube closure (GO:0090179)2.11819607
167DNA replication-dependent nucleosome assembly (GO:0006335)2.11803820
168DNA replication-dependent nucleosome organization (GO:0034723)2.11803820
169gastrulation with mouth forming second (GO:0001702)2.11715828
170ectoderm development (GO:0007398)2.11005438
171negative regulation of potassium ion transmembrane transport (GO:1901380)2.10511662
172establishment of protein localization to Golgi (GO:0072600)2.08496774
173lateral sprouting from an epithelium (GO:0060601)2.07960504
174regulation of cell fate commitment (GO:0010453)2.07090091
175mesoderm formation (GO:0001707)2.05754315
176negative regulation of epidermal cell differentiation (GO:0045605)2.05408284
177head development (GO:0060322)2.05175135
178DNA duplex unwinding (GO:0032508)2.04899118
179regulation of telomere maintenance (GO:0032204)2.04743018
180mRNA splice site selection (GO:0006376)2.04516364
181regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.04262520
182regulation of nucleobase-containing compound transport (GO:0032239)2.03585302
183establishment of apical/basal cell polarity (GO:0035089)2.02618160
184anterior/posterior axis specification, embryo (GO:0008595)2.02127137
185embryonic foregut morphogenesis (GO:0048617)2.02118573
186DNA geometric change (GO:0032392)2.01586345
187dendritic spine organization (GO:0097061)2.01327330
188retrograde transport, vesicle recycling within Golgi (GO:0000301)2.00684384
189regulation of cell fate specification (GO:0042659)1.98904225
190histone H3-K9 demethylation (GO:0033169)1.98129051
191histone lysine demethylation (GO:0070076)1.96129735
192spindle assembly involved in mitosis (GO:0090307)1.95580103
193microtubule cytoskeleton organization involved in mitosis (GO:1902850)1.95447467
194regulation of RNA stability (GO:0043487)1.95424799
195protein localization to chromosome, centromeric region (GO:0071459)1.94942554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.71740312
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.57278045
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.57278045
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.57278045
5POU3F2_20337985_ChIP-ChIP_501MEL_Human3.01295705
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68121694
7TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.66357292
8E2F7_22180533_ChIP-Seq_HELA_Human2.65007331
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.62855086
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.61300794
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.60208130
12GBX2_23144817_ChIP-Seq_PC3_Human2.56406940
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55120823
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52868468
15ZNF274_21170338_ChIP-Seq_K562_Hela2.52049219
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44611992
17* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.34231017
18SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.31076000
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.30643762
20VDR_22108803_ChIP-Seq_LS180_Human2.30182495
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.23453665
22IGF1R_20145208_ChIP-Seq_DFB_Human2.19678771
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.17923730
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15734762
25P300_19829295_ChIP-Seq_ESCs_Human2.15501538
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.13752305
27* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13164032
28* EWS_26573619_Chip-Seq_HEK293_Human2.11489188
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.09601688
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.09441956
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08326251
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99229185
33TAF15_26573619_Chip-Seq_HEK293_Human1.98104885
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.94135703
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93583147
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.91776369
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.90401887
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87566147
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.81057102
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79736594
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77981815
42* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.77722789
43* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77418430
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.74702621
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74518981
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73955165
47* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73835115
48* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72758689
49FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.72715940
50* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.70834888
51* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.68934027
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.68932788
53SMAD4_21799915_ChIP-Seq_A2780_Human1.65644025
54ER_23166858_ChIP-Seq_MCF-7_Human1.63539528
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62403612
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61555882
57* SMAD_19615063_ChIP-ChIP_OVARY_Human1.60158356
58* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58684197
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57989785
60* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57804538
61BCAT_22108803_ChIP-Seq_LS180_Human1.57177396
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.56719867
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54332373
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53541612
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52840275
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52606201
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52267957
68* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.52189135
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51868875
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51421542
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50810249
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.50005557
73* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49461329
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49024371
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48916755
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48466076
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48094715
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48070290
79AR_25329375_ChIP-Seq_VCAP_Human1.45784850
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44967528
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43597903
82CBP_20019798_ChIP-Seq_JUKART_Human1.43569092
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43569092
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.42865766
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.42403767
86* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40953405
87* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40848683
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39667199
89CDX2_22108803_ChIP-Seq_LS180_Human1.39378028
90STAT3_23295773_ChIP-Seq_U87_Human1.37614575
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.35419053
92TCF4_22108803_ChIP-Seq_LS180_Human1.34820450
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.34809369
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32931332
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.32353944
96* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31371247
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30613693
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29018980
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28216099
100* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27662905
101KDM2B_26808549_Chip-Seq_K562_Human1.26050487
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25927584
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25284241
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23666920
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23160526
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.23075646
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22516890
108P53_22387025_ChIP-Seq_ESCs_Mouse1.21471783
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.21393929
110* NANOG_19829295_ChIP-Seq_ESCs_Human1.21384758
111* SOX2_19829295_ChIP-Seq_ESCs_Human1.21384758
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20221692
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19578739
114NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19578739
115E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18650702
116* TCF4_23295773_ChIP-Seq_U87_Human1.17840121
117PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17524588
118* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17227251
119* CJUN_26792858_Chip-Seq_BT549_Human1.16135331
120AHR_22903824_ChIP-Seq_MCF-7_Human1.15416252
121PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.15292672
122* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15093544
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.14642328
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14395842
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13960373
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13938018
127TP53_18474530_ChIP-ChIP_U2OS_Human1.13323501
128SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13208193
129CMYC_18555785_Chip-Seq_ESCs_Mouse1.12952555
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.12219135
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11719602
132* CLOCK_20551151_ChIP-Seq_293T_Human1.11391720
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11177061
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10921722
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.09972667
136YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09725344
137P300_18555785_Chip-Seq_ESCs_Mouse1.09599728
138RUNX2_22187159_ChIP-Seq_PCA_Human1.09445808
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09006540
140P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08666147
141* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08596529
142BRD4_25478319_ChIP-Seq_HGPS_Human1.07938531
143FLI1_21867929_ChIP-Seq_TH2_Mouse1.07763042
144TP53_16413492_ChIP-PET_HCT116_Human1.07614586
145STAT3_18555785_Chip-Seq_ESCs_Mouse1.07594607
146TCF4_18268006_ChIP-ChIP_LS174T_Human1.06790724
147ESR2_21235772_ChIP-Seq_MCF-7_Human1.06611641
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06413849
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05217610
150NOTCH1_21737748_ChIP-Seq_TLL_Human1.05003655
151CHD1_26751641_Chip-Seq_LNCaP_Human1.04150087
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03666950
153TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02626135
154NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02552021
155FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02082451
156KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01664306
157FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01282550
158SOX2_18555785_Chip-Seq_ESCs_Mouse1.00611188
159ESR1_21235772_ChIP-Seq_MCF-7_Human1.00492182
160OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00400388
161SOX2_16153702_ChIP-ChIP_HESCs_Human1.00055856
162TCF7_22412390_ChIP-Seq_EML_Mouse1.00050411
163KLF5_25053715_ChIP-Seq_YYC3_Human0.98231648
164RUNX1_27514584_Chip-Seq_MCF-7_Human0.97364212
165KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96937595
166RNF2_27304074_Chip-Seq_ESCs_Mouse0.96159984
167FUS_26573619_Chip-Seq_HEK293_Human0.95630180
168KDM2B_26808549_Chip-Seq_DND41_Human0.95052385
169ESR1_20079471_ChIP-ChIP_T-47D_Human0.94633261
170ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94513619
171RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93864188
172EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93864188
173KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93561719
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92843579
175POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91820879
176HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91749791
177NANOG_16153702_ChIP-ChIP_HESCs_Human0.91431275
178SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90716682
179PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90563807
180ZNF263_19887448_ChIP-Seq_K562_Human0.89713072
181SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89145915
182SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88208673
183SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87894878
184KDM2B_26808549_Chip-Seq_JURKAT_Human0.87886218
185SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87795044
186SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87795044
187NANOG_21062744_ChIP-ChIP_HESCs_Human0.87583574
188* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87094252
189MYC_22102868_ChIP-Seq_BL_Human0.86389455
190CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83963042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.63915084
2MP0003195_calcinosis3.27072110
3MP0009780_abnormal_chondrocyte_physiolo3.01386976
4MP0002102_abnormal_ear_morphology2.57776760
5MP0000537_abnormal_urethra_morphology2.41606316
6MP0003705_abnormal_hypodermis_morpholog2.40747046
7MP0010352_gastrointestinal_tract_polyps2.40308493
8MP0002837_dystrophic_cardiac_calcinosis2.34801753
9MP0004264_abnormal_extraembryonic_tissu2.31477089
10MP0008877_abnormal_DNA_methylation2.28184723
11MP0003121_genomic_imprinting2.10717125
12MP0003890_abnormal_embryonic-extraembry2.04780861
13MP0002877_abnormal_melanocyte_morpholog2.03601018
14MP0003950_abnormal_plasma_membrane2.00430181
15MP0010678_abnormal_skin_adnexa1.99052458
16MP0003122_maternal_imprinting1.93683028
17MP0001984_abnormal_olfaction1.90768855
18MP0003123_paternal_imprinting1.88184521
19MP0005379_endocrine/exocrine_gland_phen1.83316234
20MP0005275_abnormal_skin_tensile1.82452332
21MP0005623_abnormal_meninges_morphology1.72775787
22MP0009697_abnormal_copulation1.68319839
23MP0001849_ear_inflammation1.66637256
24MP0010030_abnormal_orbit_morphology1.65328666
25MP0003787_abnormal_imprinting1.64380615
26MP0000372_irregular_coat_pigmentation1.63116562
27MP0003283_abnormal_digestive_organ1.62857600
28MP0005253_abnormal_eye_physiology1.60419592
29MP0003937_abnormal_limbs/digits/tail_de1.59845365
30MP0008058_abnormal_DNA_repair1.59128099
31MP0005076_abnormal_cell_differentiation1.57777971
32MP0002090_abnormal_vision1.55015973
33MP0000383_abnormal_hair_follicle1.54507586
34MP0004858_abnormal_nervous_system1.53668519
35MP0003119_abnormal_digestive_system1.53031781
36MP0002009_preneoplasia1.49176027
37MP0003935_abnormal_craniofacial_develop1.46494417
38MP0000428_abnormal_craniofacial_morphol1.46472490
39MP0004215_abnormal_myocardial_fiber1.46125376
40MP0002084_abnormal_developmental_patter1.45915227
41MP0002254_reproductive_system_inflammat1.44560106
42MP0005084_abnormal_gallbladder_morpholo1.44077214
43MP0005551_abnormal_eye_electrophysiolog1.42288146
44MP0004272_abnormal_basement_membrane1.41554520
45MP0003755_abnormal_palate_morphology1.39927576
46MP0002163_abnormal_gland_morphology1.39856232
47MP0003718_maternal_effect1.37963425
48MP0003786_premature_aging1.34537922
49MP0005220_abnormal_exocrine_pancreas1.33965763
50MP0001299_abnormal_eye_distance/1.32686610
51MP0008438_abnormal_cutaneous_collagen1.32547248
52MP0005499_abnormal_olfactory_system1.32141719
53MP0005394_taste/olfaction_phenotype1.32141719
54MP0002234_abnormal_pharynx_morphology1.31282610
55MP0000762_abnormal_tongue_morphology1.30376039
56MP0000678_abnormal_parathyroid_gland1.30003745
57MP0002751_abnormal_autonomic_nervous1.28494680
58MP0002653_abnormal_ependyma_morphology1.28216584
59MP0002085_abnormal_embryonic_tissue1.28196040
60MP0005367_renal/urinary_system_phenotyp1.27005311
61MP0000516_abnormal_urinary_system1.27005311
62MP0004197_abnormal_fetal_growth/weight/1.26514329
63MP0005248_abnormal_Harderian_gland1.26322902
64MP0003941_abnormal_skin_development1.25831286
65MP0002876_abnormal_thyroid_physiology1.25186143
66MP0002233_abnormal_nose_morphology1.24774731
67MP0002796_impaired_skin_barrier1.22742191
68MP0000432_abnormal_head_morphology1.22393363
69MP0000733_abnormal_muscle_development1.21981391
70MP0008961_abnormal_basal_metabolism1.20235696
71MP0002909_abnormal_adrenal_gland1.19621603
72MP0001188_hyperpigmentation1.18541492
73MP0005187_abnormal_penis_morphology1.18532938
74MP0003880_abnormal_central_pattern1.18084040
75MP0001293_anophthalmia1.17950642
76MP0002092_abnormal_eye_morphology1.17946293
77MP0009250_abnormal_appendicular_skeleto1.17646004
78MP0002932_abnormal_joint_morphology1.17180142
79MP0005380_embryogenesis_phenotype1.16140513
80MP0001672_abnormal_embryogenesis/_devel1.16140513
81MP0004043_abnormal_pH_regulation1.15570275
82MP0003942_abnormal_urinary_system1.12532097
83MP0003861_abnormal_nervous_system1.11795182
84MP0004270_analgesia1.11384369
85MP0002088_abnormal_embryonic_growth/wei1.10713417
86MP0003315_abnormal_perineum_morphology1.10614204
87MP0000534_abnormal_ureter_morphology1.10372225
88MP0010094_abnormal_chromosome_stability1.10224216
89MP0001529_abnormal_vocalization1.10217154
90MP0000613_abnormal_salivary_gland1.09781521
91MP0002116_abnormal_craniofacial_bone1.09455609
92MP0003938_abnormal_ear_development1.08833989
93MP0000049_abnormal_middle_ear1.08289775
94MP0003984_embryonic_growth_retardation1.07959418
95MP0003385_abnormal_body_wall1.07958507
96MP0002086_abnormal_extraembryonic_tissu1.07322399
97MP0000467_abnormal_esophagus_morphology1.07211392
98MP0009046_muscle_twitch1.07074855
99MP0006054_spinal_hemorrhage1.06915230
100MP0005395_other_phenotype1.06781855
101MP0000647_abnormal_sebaceous_gland1.06718906
102MP0002925_abnormal_cardiovascular_devel1.06352282
103MP0000778_abnormal_nervous_system1.06102112
104MP0003300_gastrointestinal_ulcer1.05192754
105MP0000377_abnormal_hair_follicle1.05084425
106MP0000350_abnormal_cell_proliferation1.05002511
107MP0000569_abnormal_digit_pigmentation1.04799136
108MP0005508_abnormal_skeleton_morphology1.04468995
109MP0002098_abnormal_vibrissa_morphology1.03779428
110MP0001944_abnormal_pancreas_morphology1.02825357
111MP0000538_abnormal_urinary_bladder1.02111437
112MP0002114_abnormal_axial_skeleton1.01887901
113MP0004185_abnormal_adipocyte_glucose1.01669853
114MP0006292_abnormal_olfactory_placode0.99211522
115MP0003566_abnormal_cell_adhesion0.98806362
116MP0009703_decreased_birth_body0.98353725
117MP0002736_abnormal_nociception_after0.98167496
118MP0002295_abnormal_pulmonary_circulatio0.98057858
119MP0002928_abnormal_bile_duct0.97803585
120MP0010386_abnormal_urinary_bladder0.96333761
121MP0002168_other_aberrant_phenotype0.95419245
122MP0004957_abnormal_blastocyst_morpholog0.95416391
123MP0001697_abnormal_embryo_size0.93891024
124MP0003091_abnormal_cell_migration0.93636556
125MP0000462_abnormal_digestive_system0.93525395
126MP0008789_abnormal_olfactory_epithelium0.93338146
127MP0005645_abnormal_hypothalamus_physiol0.92825728
128MP0008007_abnormal_cellular_replicative0.92307616
129MP0009384_cardiac_valve_regurgitation0.90874499
130MP0000427_abnormal_hair_cycle0.90764311
131MP0006072_abnormal_retinal_apoptosis0.89768151
132MP0005646_abnormal_pituitary_gland0.89440845
133MP0008872_abnormal_physiological_respon0.89238396
134MP0001485_abnormal_pinna_reflex0.88850567
135MP0003011_delayed_dark_adaptation0.88702198
136MP0004133_heterotaxia0.88456676
137MP0000631_abnormal_neuroendocrine_gland0.88325557
138MP0002081_perinatal_lethality0.87070696
139MP0002697_abnormal_eye_size0.86456192
140MP0001730_embryonic_growth_arrest0.86270729
141MP0002160_abnormal_reproductive_system0.84957395
142MP0005257_abnormal_intraocular_pressure0.84655252
143MP0008057_abnormal_DNA_replication0.84625209
144MP0001286_abnormal_eye_development0.84335275
145MP0008775_abnormal_heart_ventricle0.84041694
146MP0002938_white_spotting0.83278940
147MP0002638_abnormal_pupillary_reflex0.82305602
148MP0001756_abnormal_urination0.82268095
149MP0003943_abnormal_hepatobiliary_system0.82196812
150MP0000639_abnormal_adrenal_gland0.81496940
151MP0004085_abnormal_heartbeat0.81408309
152MP0000013_abnormal_adipose_tissue0.80691554
153MP0001661_extended_life_span0.79486341
154MP0003115_abnormal_respiratory_system0.78981830
155MP0005174_abnormal_tail_pigmentation0.78332775
156MP0005332_abnormal_amino_acid0.77210775
157MP0001177_atelectasis0.75423076
158MP0006036_abnormal_mitochondrial_physio0.74106679
159MP0010307_abnormal_tumor_latency0.72140973
160MP0005389_reproductive_system_phenotype0.69486062
161MP0002282_abnormal_trachea_morphology0.69023237
162MP0004484_altered_response_of0.68881398
163MP0001929_abnormal_gametogenesis0.68525218
164MP0002693_abnormal_pancreas_physiology0.67882216
165MP0000653_abnormal_sex_gland0.64904287
166MP0003567_abnormal_fetal_cardiomyocyte0.64847918
167MP0005391_vision/eye_phenotype0.64797881
168MP0005075_abnormal_melanosome_morpholog0.64785720
169MP0002734_abnormal_mechanical_nocicepti0.63119651

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)3.45989955
2Hypothermia (HP:0002045)3.43319582
3Hepatoblastoma (HP:0002884)3.28559426
4Bilateral microphthalmos (HP:0007633)3.18842238
5Hypoglycemic coma (HP:0001325)3.13831731
6Intestinal atresia (HP:0011100)3.05482188
7Pancreatic cysts (HP:0001737)2.97070993
8Ependymoma (HP:0002888)2.96189662
9Medial flaring of the eyebrow (HP:0010747)2.82772495
10Abnormality of the astrocytes (HP:0100707)2.78348391
11Astrocytoma (HP:0009592)2.78348391
12Pancreatic fibrosis (HP:0100732)2.77099112
13True hermaphroditism (HP:0010459)2.72625619
14Neoplasm of the adrenal cortex (HP:0100641)2.69656906
15Volvulus (HP:0002580)2.59297711
16Abnormality of endocrine pancreas physiology (HP:0012093)2.52412846
17Abnormality of the pancreatic islet cells (HP:0006476)2.52412846
18Hyperglycemia (HP:0003074)2.49261422
19Large for gestational age (HP:0001520)2.45380399
20Symptomatic seizures (HP:0011145)2.44071134
21Abnormality of the labia minora (HP:0012880)2.43158565
22Ketoacidosis (HP:0001993)2.41991620
23Breast carcinoma (HP:0003002)2.39443752
24Sensory axonal neuropathy (HP:0003390)2.35787134
25Macroorchidism (HP:0000053)2.34980438
26Congenital primary aphakia (HP:0007707)2.33818860
27Neoplasm of the heart (HP:0100544)2.32441189
28Methylmalonic acidemia (HP:0002912)2.31636622
29Hamartoma of the eye (HP:0010568)2.31281069
30Ankyloglossia (HP:0010296)2.29015027
31Abnormality of the renal cortex (HP:0011035)2.28948043
32Renal duplication (HP:0000075)2.26926232
33Abnormality of midbrain morphology (HP:0002418)2.26787064
34Molar tooth sign on MRI (HP:0002419)2.26787064
35Rib fusion (HP:0000902)2.26451939
36Gait imbalance (HP:0002141)2.24862068
37Thyroiditis (HP:0100646)2.23766432
38Hypoplastic labia majora (HP:0000059)2.22798729
39Neoplasm of the adrenal gland (HP:0100631)2.22113286
40Adrenal hypoplasia (HP:0000835)2.19361177
41Genital tract atresia (HP:0001827)2.19067144
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.18065383
43Abnormality of methionine metabolism (HP:0010901)2.17841533
44Median cleft lip (HP:0000161)2.16986911
45Disproportionate short-trunk short stature (HP:0003521)2.16714324
46Abnormality of the salivary glands (HP:0010286)2.14772060
47Progressive macrocephaly (HP:0004481)2.14475514
48Shallow orbits (HP:0000586)2.14416272
49Glioma (HP:0009733)2.12854968
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11895514
51Furrowed tongue (HP:0000221)2.11598885
52Nephronophthisis (HP:0000090)2.09865441
53Nephrogenic diabetes insipidus (HP:0009806)2.07074764
54Vaginal atresia (HP:0000148)2.04196498
55Abnormality of vitamin B metabolism (HP:0004340)2.03982163
56Abnormality of the labia majora (HP:0012881)2.03098173
57Delayed gross motor development (HP:0002194)2.01577178
58Abnormality of the metopic suture (HP:0005556)2.01333866
59Bifid tongue (HP:0010297)2.00160102
60Abnormality of the lower motor neuron (HP:0002366)1.99951759
61Abnormality of the renal medulla (HP:0100957)1.99937335
62Subacute progressive viral hepatitis (HP:0006572)1.99069009
63Abnormal biliary tract morphology (HP:0012440)1.97024294
64Neoplasm of striated muscle (HP:0009728)1.96392616
65Enlarged penis (HP:0000040)1.95927279
66Renal cortical cysts (HP:0000803)1.95729705
67Abnormality of chromosome segregation (HP:0002916)1.95359694
68Conjunctival hamartoma (HP:0100780)1.95311477
69Prominent metopic ridge (HP:0005487)1.94144175
70Mildly elevated creatine phosphokinase (HP:0008180)1.93220943
71Labial hypoplasia (HP:0000066)1.91672160
72Transitional cell carcinoma of the bladder (HP:0006740)1.91278970
73Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91152559
74Short 4th metacarpal (HP:0010044)1.91152559
75Difficulty running (HP:0009046)1.91129781
76Hematochezia (HP:0002573)1.90825713
77Missing ribs (HP:0000921)1.90019858
78Hypomagnesemia (HP:0002917)1.90010311
79Tongue fasciculations (HP:0001308)1.89348261
80Aplasia/hypoplasia of the uterus (HP:0008684)1.89285650
81Nephroblastoma (Wilms tumor) (HP:0002667)1.88511220
82Gastrointestinal carcinoma (HP:0002672)1.88142382
83Malignant gastrointestinal tract tumors (HP:0006749)1.88142382
84Abnormality of oral frenula (HP:0000190)1.88009129
85Embryonal renal neoplasm (HP:0011794)1.86450384
86Amyotrophic lateral sclerosis (HP:0007354)1.86443060
87Progressive inability to walk (HP:0002505)1.86290426
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.85361411
89Hypoplasia of the fovea (HP:0007750)1.85361411
90Abnormal sex determination (HP:0012244)1.85322760
91Sex reversal (HP:0012245)1.85322760
92Postaxial hand polydactyly (HP:0001162)1.83624482
93Colon cancer (HP:0003003)1.82638533
94Hypochromic microcytic anemia (HP:0004840)1.82257123
95Neoplasm of the oral cavity (HP:0100649)1.80396491
96Popliteal pterygium (HP:0009756)1.79986283
97Hypoplastic female external genitalia (HP:0012815)1.79702557
98Esophageal atresia (HP:0002032)1.79354832
99Muscular hypotonia of the trunk (HP:0008936)1.78527487
100Bladder neoplasm (HP:0009725)1.78352137
101Bladder carcinoma (HP:0002862)1.78352137
102Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78101167
103Lip pit (HP:0100267)1.77477808
104Short humerus (HP:0005792)1.77203952
105Buphthalmos (HP:0000557)1.76776758
106Skin pits (HP:0100276)1.76472695
107Abnormality of chromosome stability (HP:0003220)1.75793194
108Male pseudohermaphroditism (HP:0000037)1.75664719
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.74918576
110Uterine leiomyosarcoma (HP:0002891)1.74044877
111Leiomyosarcoma (HP:0100243)1.74044877
112Papillary thyroid carcinoma (HP:0002895)1.73747739
113Thyroid carcinoma (HP:0002890)1.72577568
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.71524856
115Cutaneous melanoma (HP:0012056)1.70994328
116Atrophic scars (HP:0001075)1.70938419
117Cystic liver disease (HP:0006706)1.70511969
118Protrusio acetabuli (HP:0003179)1.69802667
119Renal hypoplasia (HP:0000089)1.69346754
120Preaxial hand polydactyly (HP:0001177)1.69324075
121Chronic hepatic failure (HP:0100626)1.69071966
122Abnormality of macular pigmentation (HP:0008002)1.68887426
123Gastrointestinal atresia (HP:0002589)1.68772315
124Postaxial foot polydactyly (HP:0001830)1.68494660
125Shawl scrotum (HP:0000049)1.68265612
126Heterotopia (HP:0002282)1.67546831
127Tubular atrophy (HP:0000092)1.67479545
128Curly hair (HP:0002212)1.67349284
129Methylmalonic aciduria (HP:0012120)1.66839454
130Hyperventilation (HP:0002883)1.66647029
131Gaze-evoked nystagmus (HP:0000640)1.66519227
132Abnormality of the fovea (HP:0000493)1.66191987
133Abnormal pancreas size (HP:0012094)1.66134143
134Hypopigmentation of the fundus (HP:0007894)1.65657749
135Fused cervical vertebrae (HP:0002949)1.65595629
136Hemiparesis (HP:0001269)1.64734868
137Pelvic girdle muscle weakness (HP:0003749)1.63111068
138Absent frontal sinuses (HP:0002688)1.62212553
139Small hand (HP:0200055)1.61995403
140Broad palm (HP:0001169)1.61395099
141Posterior subcapsular cataract (HP:0007787)1.60801463
142Biliary tract neoplasm (HP:0100574)1.60772575
143Shoulder girdle muscle weakness (HP:0003547)1.60669616
144Hyperinsulinemic hypoglycemia (HP:0000825)1.60651003
145Rhabdomyosarcoma (HP:0002859)1.60048342
146Acute necrotizing encephalopathy (HP:0006965)1.59518850
147Premature rupture of membranes (HP:0001788)1.58904537
148Broad thumb (HP:0011304)1.58117027
149Palmar hyperkeratosis (HP:0010765)1.57793072
150Tubulointerstitial nephritis (HP:0001970)1.57456998
151Milia (HP:0001056)1.55854938
152Mitral valve prolapse (HP:0001634)1.55126181
153Periauricular skin pits (HP:0100277)1.54606896
154Preauricular pit (HP:0004467)1.54606896
155Aplasia/hypoplasia of the humerus (HP:0006507)1.52958879
156Increased nuchal translucency (HP:0010880)1.51314228
157Ankle contracture (HP:0006466)1.48277799
158Skin tags (HP:0010609)1.48208604
159Overgrowth (HP:0001548)1.48036651
160Abnormality of the corticospinal tract (HP:0002492)1.47826759
161Arterial tortuosity (HP:0005116)1.47605472
162Abnormality of the musculature of the pelvis (HP:0001469)1.47350479
163Abnormality of the hip-girdle musculature (HP:0001445)1.47350479
164Abnormality of the pubic bones (HP:0003172)1.46863570
165Open mouth (HP:0000194)1.46271755
166Large earlobe (HP:0009748)1.46226077
167Pancreatic islet-cell hyperplasia (HP:0004510)1.46124265
168Supernumerary ribs (HP:0005815)1.46039079
169Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.44592156
170Fibrous tissue neoplasm (HP:0012316)1.43515638
171Prominent occiput (HP:0000269)1.43318669
172Thin bony cortex (HP:0002753)1.43220871
173Medulloblastoma (HP:0002885)1.43107289
174Cutaneous finger syndactyly (HP:0010554)1.41722399
175Deviation of the hallux (HP:0010051)1.40828689
176Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40783630
177Genu recurvatum (HP:0002816)1.40589106
178Abnormality of the 4th metacarpal (HP:0010012)1.40162642
179Increased connective tissue (HP:0009025)1.39777877
180Scapular winging (HP:0003691)1.39629926
181Preauricular skin tag (HP:0000384)1.39237414
182Fibroma (HP:0010614)1.39192409
183Uterine neoplasm (HP:0010784)1.38859523
184Bladder diverticulum (HP:0000015)1.38306975
185Bowel diverticulosis (HP:0005222)1.37587201
186Aqueductal stenosis (HP:0002410)1.37237549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.00899547
2TRIM283.97977874
3MST43.22678248
4LATS13.07847500
5EIF2AK32.69361796
6WNK32.65008261
7BMPR1B2.55397428
8MKNK22.48900847
9TYRO32.45500479
10ACVR1B2.17986273
11TNIK2.01261523
12PDGFRA1.96343891
13SCYL21.94309110
14BRSK21.92027786
15MAP4K21.90073545
16PLK21.86383035
17MAP3K21.83091068
18FRK1.81821331
19NTRK11.74855658
20GRK51.73233275
21KSR21.71954756
22LATS21.70242984
23PLK31.69814503
24AKT31.68905091
25KSR11.67576082
26STK38L1.63692723
27CASK1.62055914
28FGFR21.61985321
29EIF2AK11.61893772
30PASK1.61619178
31FER1.60284742
32MAP3K91.59462544
33PAK31.57640510
34RIPK11.54310581
35GRK11.53356083
36FGFR31.53103765
37HIPK21.51999696
38MKNK11.46167728
39TTK1.44510032
40WNK11.37037865
41ERN11.27871146
42CDC71.27224580
43DDR21.26978129
44BUB11.25820793
45MAP3K121.24292150
46SIK31.23573510
47EEF2K1.23436386
48OXSR11.21839685
49PTK21.21410047
50BRD41.21087135
51MAP3K101.19769000
52TSSK61.18774133
53NTRK31.18041155
54MET1.17053324
55STK101.15888820
56EPHA21.15232575
57CSNK1G11.15001096
58ALK1.14574388
59PRKCE1.14494356
60WEE11.13106439
61GRK61.12059564
62TRIB31.11150900
63EPHA41.10082915
64STK241.09968917
65MOS1.09505203
66EPHA31.09504046
67PAK61.07535729
68STK31.06969458
69PTK61.04776089
70MARK21.04701377
71ZAK1.03133849
72NLK1.02291462
73MARK11.02156801
74TAF11.01708396
75PDGFRB1.00386956
76FGFR10.99155056
77RET0.98047156
78PBK0.94317092
79TGFBR20.93657881
80CDK60.92168474
81RPS6KB20.91958015
82PAK40.91436680
83CSNK1G30.91343043
84CHEK20.89761320
85MAPK130.89280303
86DMPK0.88242570
87MTOR0.88104132
88PINK10.86094805
89PKN20.85237544
90ADRBK20.83870653
91ERBB30.83604802
92NEK10.83586852
93EPHB20.82601618
94PHKG10.80576193
95PHKG20.80576193
96MAP3K40.79078667
97CSNK1A1L0.78717573
98DYRK30.78240786
99DYRK1B0.77372711
100PAK20.76584444
101DYRK20.75871783
102DYRK1A0.75243595
103PRKD30.73950852
104BCR0.73453727
105MELK0.72039509
106MUSK0.72025794
107MAP3K70.69773732
108INSRR0.68063088
109CHEK10.66064084
110MYLK0.65374185
111TTN0.65354738
112TRPM70.65296317
113MAPK70.64695023
114ERBB40.63804481
115SRPK10.63224174
116EPHB10.62090158
117EIF2AK20.60849608
118ERBB20.60842833
119PLK10.58807291
120PLK40.58588684
121MAPK100.58209924
122LMTK20.56949417
123CSF1R0.55145689
124NUAK10.54422719
125CSNK1D0.53538483
126NTRK20.53253464
127FLT30.52322109
128BRSK10.51496721
129CSNK1G20.51009775
130ATM0.50982797
131INSR0.50929970
132STK390.50829215
133LIMK10.50743865
134MAP2K40.50413809
135CDK140.50362151
136TGFBR10.50267855
137STK160.48396635
138YES10.48337014
139ROCK10.47493786
140CDK70.46306876
141CSNK1E0.46042781
142MAPKAPK30.45010308
143CDK20.44970099
144PRKCG0.44774867
145IRAK10.44697029
146PNCK0.43908583
147MAP2K70.41958132
148NEK20.41845799
149PRKCI0.41592554
150UHMK10.41544064
151CDK90.41042504
152CDK10.39680039
153CAMK2D0.39427228
154GSK3A0.39417309
155CDK150.39406475
156GSK3B0.38824462
157MINK10.37569531
158VRK10.35486962
159PTK2B0.34538284
160MST1R0.33586644
161ADRBK10.33517865
162PDK20.30109026
163WNK40.29048226
164TIE10.28401706
165CSNK1A10.25640283
166EGFR0.23138039
167ROCK20.21785217

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.08266969
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.04409518
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81951416
4Non-homologous end-joining_Homo sapiens_hsa034502.56997931
5Propanoate metabolism_Homo sapiens_hsa006402.53169985
6Proteasome_Homo sapiens_hsa030502.49022192
7Vitamin B6 metabolism_Homo sapiens_hsa007502.40482631
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29422103
9Butanoate metabolism_Homo sapiens_hsa006502.01488635
10Basal transcription factors_Homo sapiens_hsa030221.93187395
11Fatty acid elongation_Homo sapiens_hsa000621.88695631
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85244752
13Selenocompound metabolism_Homo sapiens_hsa004501.79636129
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78612020
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75454243
16Steroid biosynthesis_Homo sapiens_hsa001001.68652381
17Adherens junction_Homo sapiens_hsa045201.64411295
18Hippo signaling pathway_Homo sapiens_hsa043901.60758658
19Long-term potentiation_Homo sapiens_hsa047201.59330860
20Circadian rhythm_Homo sapiens_hsa047101.57139733
21MicroRNAs in cancer_Homo sapiens_hsa052061.52999507
22RNA degradation_Homo sapiens_hsa030181.48890974
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48106379
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47268429
25Basal cell carcinoma_Homo sapiens_hsa052171.46621310
26Axon guidance_Homo sapiens_hsa043601.46342988
27Fanconi anemia pathway_Homo sapiens_hsa034601.44191600
28mTOR signaling pathway_Homo sapiens_hsa041501.43783998
29Sulfur metabolism_Homo sapiens_hsa009201.43131599
30Colorectal cancer_Homo sapiens_hsa052101.38232023
31Homologous recombination_Homo sapiens_hsa034401.37942464
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37448162
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33943524
34Proteoglycans in cancer_Homo sapiens_hsa052051.32285863
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32261041
36Endometrial cancer_Homo sapiens_hsa052131.31446761
37Focal adhesion_Homo sapiens_hsa045101.30925820
38Dorso-ventral axis formation_Homo sapiens_hsa043201.30370482
39Tight junction_Homo sapiens_hsa045301.29079162
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28506973
41Renal cell carcinoma_Homo sapiens_hsa052111.27272522
42Thyroid cancer_Homo sapiens_hsa052161.27193822
43GnRH signaling pathway_Homo sapiens_hsa049121.26808626
44Phototransduction_Homo sapiens_hsa047441.26600421
45VEGF signaling pathway_Homo sapiens_hsa043701.26166854
46Regulation of autophagy_Homo sapiens_hsa041401.25777473
47Glioma_Homo sapiens_hsa052141.25765852
48RNA polymerase_Homo sapiens_hsa030201.25158060
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24806986
50* Wnt signaling pathway_Homo sapiens_hsa043101.24133490
51mRNA surveillance pathway_Homo sapiens_hsa030151.20866658
52Oocyte meiosis_Homo sapiens_hsa041141.17394840
53Collecting duct acid secretion_Homo sapiens_hsa049661.16570407
54ErbB signaling pathway_Homo sapiens_hsa040121.16433153
55Nitrogen metabolism_Homo sapiens_hsa009101.15705702
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14816408
57ECM-receptor interaction_Homo sapiens_hsa045121.14577623
58TGF-beta signaling pathway_Homo sapiens_hsa043501.14134175
59Long-term depression_Homo sapiens_hsa047301.13538030
60Caffeine metabolism_Homo sapiens_hsa002321.12548241
61Choline metabolism in cancer_Homo sapiens_hsa052311.12159903
62Estrogen signaling pathway_Homo sapiens_hsa049151.11842299
63Pancreatic cancer_Homo sapiens_hsa052121.11795049
64Tryptophan metabolism_Homo sapiens_hsa003801.11759251
65RNA transport_Homo sapiens_hsa030131.10614765
66Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10487886
67Chronic myeloid leukemia_Homo sapiens_hsa052201.09836009
68* Hedgehog signaling pathway_Homo sapiens_hsa043401.09118135
69Bladder cancer_Homo sapiens_hsa052191.08795306
70Melanogenesis_Homo sapiens_hsa049161.08434198
71Cell cycle_Homo sapiens_hsa041101.05919023
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05682040
73Peroxisome_Homo sapiens_hsa041461.04345520
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04146154
75Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03452312
76Phospholipase D signaling pathway_Homo sapiens_hsa040721.02427831
77Amphetamine addiction_Homo sapiens_hsa050311.02122662
78Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02114255
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01503913
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01480515
81Rap1 signaling pathway_Homo sapiens_hsa040151.01383743
82Ether lipid metabolism_Homo sapiens_hsa005651.00673813
83Glutathione metabolism_Homo sapiens_hsa004801.00481311
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00180699
85Non-small cell lung cancer_Homo sapiens_hsa052231.00151513
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.99218734
87Prostate cancer_Homo sapiens_hsa052150.98468256
88Oxytocin signaling pathway_Homo sapiens_hsa049210.97739674
89Dopaminergic synapse_Homo sapiens_hsa047280.97366422
90beta-Alanine metabolism_Homo sapiens_hsa004100.97147194
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97143478
92Small cell lung cancer_Homo sapiens_hsa052220.95844380
93Pathways in cancer_Homo sapiens_hsa052000.95796187
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.95757221
95Renin secretion_Homo sapiens_hsa049240.95632813
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.95358574
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.93501242
98Sphingolipid metabolism_Homo sapiens_hsa006000.93396087
99Gap junction_Homo sapiens_hsa045400.93336412
100Fatty acid metabolism_Homo sapiens_hsa012120.92670598
101Type II diabetes mellitus_Homo sapiens_hsa049300.91722846
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91137318
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90959859
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90035676
105Mismatch repair_Homo sapiens_hsa034300.88701194
106Dilated cardiomyopathy_Homo sapiens_hsa054140.88483583
107One carbon pool by folate_Homo sapiens_hsa006700.87879240
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87069007
109Oxidative phosphorylation_Homo sapiens_hsa001900.85643904
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85025349
111Insulin secretion_Homo sapiens_hsa049110.84995092
112Glutamatergic synapse_Homo sapiens_hsa047240.84511444
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83667534
114Alcoholism_Homo sapiens_hsa050340.83559017
115Ras signaling pathway_Homo sapiens_hsa040140.82749964
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82584002
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.82095357
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81881221
119Fatty acid degradation_Homo sapiens_hsa000710.81733198
120Inositol phosphate metabolism_Homo sapiens_hsa005620.81500694
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80505104
122Prolactin signaling pathway_Homo sapiens_hsa049170.80471989
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80285500
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80002858
125cAMP signaling pathway_Homo sapiens_hsa040240.79738000
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79462272
127MAPK signaling pathway_Homo sapiens_hsa040100.79036880
128HTLV-I infection_Homo sapiens_hsa051660.78911852
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78534359
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.78242233
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77774149
132Melanoma_Homo sapiens_hsa052180.77388946
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76778029
134Folate biosynthesis_Homo sapiens_hsa007900.75862781
135Viral carcinogenesis_Homo sapiens_hsa052030.75584532
136Protein digestion and absorption_Homo sapiens_hsa049740.74787317
137Circadian entrainment_Homo sapiens_hsa047130.74497581
138Pyruvate metabolism_Homo sapiens_hsa006200.74483080
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74480464
140Serotonergic synapse_Homo sapiens_hsa047260.74355759
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74351058
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73989860
143T cell receptor signaling pathway_Homo sapiens_hsa046600.73198279
144AMPK signaling pathway_Homo sapiens_hsa041520.72655278
145Mineral absorption_Homo sapiens_hsa049780.72389101
146Taste transduction_Homo sapiens_hsa047420.72051634
147Gastric acid secretion_Homo sapiens_hsa049710.71901800
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71487390
149p53 signaling pathway_Homo sapiens_hsa041150.71364445
150N-Glycan biosynthesis_Homo sapiens_hsa005100.70522298
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.70470108
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70277362
153Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70077703
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68681504
155Chemical carcinogenesis_Homo sapiens_hsa052040.67932011
156Retinol metabolism_Homo sapiens_hsa008300.67793569
157Notch signaling pathway_Homo sapiens_hsa043300.67537848
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66079703
159Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65951799
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65120198
161Linoleic acid metabolism_Homo sapiens_hsa005910.62976004
162Nucleotide excision repair_Homo sapiens_hsa034200.62616478
163Purine metabolism_Homo sapiens_hsa002300.61176651
164Metabolic pathways_Homo sapiens_hsa011000.60712461
165Vibrio cholerae infection_Homo sapiens_hsa051100.60238691
166Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58174447
167Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56506647
168Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55730394
169Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54907817
170Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52209688
171ABC transporters_Homo sapiens_hsa020100.51387743
172SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49187497
1732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48660347
174Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48422522
175Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45959512
176alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45954157
177Parkinsons disease_Homo sapiens_hsa050120.45937762
178Steroid hormone biosynthesis_Homo sapiens_hsa001400.45425663
179Lysine degradation_Homo sapiens_hsa003100.41610513
180Pyrimidine metabolism_Homo sapiens_hsa002400.33900262
181Glucagon signaling pathway_Homo sapiens_hsa049220.33538167

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