ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	7.52576764
2	male meiosis (GO:0007140)	7.43217438
3	piRNA metabolic process (GO:0034587)	6.35101010
4	male meiosis I (GO:0007141)	5.93914413
5	gonadal mesoderm development (GO:0007506)	5.85420870
6	chromosome organization involved in meiosis (GO:0070192)	5.51567135
7	DNA methylation involved in gamete generation (GO:0043046)	5.29233884
8	meiotic nuclear division (GO:0007126)	5.01199127
9	meiosis I (GO:0007127)	4.67798562
10	neurotransmitter-gated ion channel clustering (GO:0072578)	4.62875589
11	resolution of meiotic recombination intermediates (GO:0000712)	4.62067274
12	meiotic chromosome segregation (GO:0045132)	4.61785992
13	synaptonemal complex assembly (GO:0007130)	4.49217766
14	regulation of oxidative phosphorylation (GO:0002082)	4.45337549
15	acrosome reaction (GO:0007340)	4.40649465
16	regulation of meiosis I (GO:0060631)	4.37449215
17	spermatid development (GO:0007286)	4.22972972
18	exocrine pancreas development (GO:0031017)	4.15254292
19	synaptonemal complex organization (GO:0070193)	4.14381308
20	meiotic cell cycle process (GO:1903046)	3.94300345
21	regulation of cellular respiration (GO:0043457)	3.93927960
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.61830139
23	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.60488126
24	epithelial cilium movement (GO:0003351)	3.59814435
25	positive regulation of catecholamine secretion (GO:0033605)	3.57881353
26	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.57043359
27	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.54723678
28	binding of sperm to zona pellucida (GO:0007339)	3.54498631
29	histone H3-K9 demethylation (GO:0033169)	3.52003279
30	regulation of oxidative stress-induced neuron death (GO:1903203)	3.51692570
31	nucleobase biosynthetic process (GO:0046112)	3.48455643
32	multicellular organism reproduction (GO:0032504)	3.45541940
33	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.43865420
34	kinetochore assembly (GO:0051382)	3.38289320
35	sperm-egg recognition (GO:0035036)	3.36933625
36	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.33020131
37	behavioral response to nicotine (GO:0035095)	3.29500723
38	purine nucleobase biosynthetic process (GO:0009113)	3.27603279
39	sperm motility (GO:0030317)	3.23619901
40	histone exchange (GO:0043486)	3.22699842
41	kinetochore organization (GO:0051383)	3.17127472
42	facial nerve structural organization (GO:0021612)	3.16274413
43	oogenesis (GO:0048477)	3.09805979
44	centriole replication (GO:0007099)	3.06078665
45	DNA replication checkpoint (GO:0000076)	3.05533865
46	female gamete generation (GO:0007292)	3.03115703
47	regulation of cofactor metabolic process (GO:0051193)	3.02755860
48	regulation of coenzyme metabolic process (GO:0051196)	3.02755860
49	terpenoid biosynthetic process (GO:0016114)	3.01520098
50	gene silencing by RNA (GO:0031047)	2.97586586
51	negative regulation of gene silencing (GO:0060969)	2.96500434
52	homocysteine metabolic process (GO:0050667)	2.96454316
53	DNA synthesis involved in DNA repair (GO:0000731)	2.96364127
54	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2.91881460
55	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.90520214
56	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.90520214
57	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.90520214
58	pseudouridine synthesis (GO:0001522)	2.87805080
59	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.85839497
60	cranial nerve structural organization (GO:0021604)	2.85186481
61	sister chromatid cohesion (GO:0007062)	2.83704919
62	protein-cofactor linkage (GO:0018065)	2.82983806
63	proteasome assembly (GO:0043248)	2.80696625
64	reciprocal DNA recombination (GO:0035825)	2.79005303
65	reciprocal meiotic recombination (GO:0007131)	2.79005303
66	tongue development (GO:0043586)	2.77963508
67	germ cell development (GO:0007281)	2.77429682
68	embryonic body morphogenesis (GO:0010172)	2.75988320
69	regulation of histone H3-K9 methylation (GO:0051570)	2.75824795
70	attachment of spindle microtubules to kinetochore (GO:0008608)	2.75371790
71	meiotic cell cycle (GO:0051321)	2.73337349
72	cilium movement (GO:0003341)	2.72847648
73	motile cilium assembly (GO:0044458)	2.71910703
74	regulation of DNA endoreduplication (GO:0032875)	2.71019733
75	nonmotile primary cilium assembly (GO:0035058)	2.70507275
76	glutamine family amino acid catabolic process (GO:0009065)	2.66658856
77	DNA alkylation (GO:0006305)	2.65709556
78	DNA methylation (GO:0006306)	2.65709556
79	diterpenoid biosynthetic process (GO:0016102)	2.64720224
80	sex differentiation (GO:0007548)	2.64601249
81	regulation of sulfur metabolic process (GO:0042762)	2.63720190
82	negative regulation of response to reactive oxygen species (GO:1901032)	2.62128598
83	regulation of cilium movement (GO:0003352)	2.58581489
84	regulation of microtubule-based movement (GO:0060632)	2.57512014
85	cell-cell recognition (GO:0009988)	2.57065244
86	cilium or flagellum-dependent cell motility (GO:0001539)	2.56146685
87	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.54567533
88	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.54468943
89	DNA replication initiation (GO:0006270)	2.54122065
90	cilium morphogenesis (GO:0060271)	2.52633966
91	centriole assembly (GO:0098534)	2.51824587
92	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.48014839
93	regulation of dopamine secretion (GO:0014059)	2.46154782
94	double-strand break repair via homologous recombination (GO:0000724)	2.45413079
95	IMP biosynthetic process (GO:0006188)	2.44604287
96	reproduction (GO:0000003)	2.44263585
97	organic cation transport (GO:0015695)	2.43609351
98	single strand break repair (GO:0000012)	2.42889971
99	recombinational repair (GO:0000725)	2.42882587
100	regulation of gene expression by genetic imprinting (GO:0006349)	2.42008987

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.58412827
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.23342439
3	VDR_22108803_ChIP-Seq_LS180_Human	3.94934994
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.20655680
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.05415761
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.82913708
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.72889562
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.68351827
9	FUS_26573619_Chip-Seq_HEK293_Human	2.63368695
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.60492515
11	AR_21572438_ChIP-Seq_LNCaP_Human	2.59525234
12	GATA1_22025678_ChIP-Seq_K562_Human	2.55667356
13	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.39379384
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.38836974
15	EWS_26573619_Chip-Seq_HEK293_Human	2.32523682
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.29159993
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19914327
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06190321
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.05079234
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.91219307
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88788995
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.88302972
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.86527583
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80008235
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.76663043
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.74657718
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.73705436
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.71155100
29	P300_19829295_ChIP-Seq_ESCs_Human	1.70642548
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.67751516
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67751516
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63806186
33	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63806186
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.61368906
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.61319676
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.58104581
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52303703
38	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.49874444
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49687376
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45185833
41	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.44119833
42	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.40830278
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38109425
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.37359837
45	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.36114539
46	TCF4_23295773_ChIP-Seq_U87_Human	1.33217388
47	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32628288
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.32448058
49	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.30574523
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30433273
51	HOXB7_26014856_ChIP-Seq_BT474_Human	1.28856576
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28600906
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26667119
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25568087
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23388501
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23356130
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20878202
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.18037645
59	AR_25329375_ChIP-Seq_VCAP_Human	1.15913634
60	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.15870340
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15696121
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14798569
63	ERG_20517297_ChIP-Seq_VCAP_Human	1.14145345
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.09386120
65	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.09239295
66	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.09144864
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08504751
68	STAT3_23295773_ChIP-Seq_U87_Human	1.08283780
69	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.07370507
70	VDR_23849224_ChIP-Seq_CD4+_Human	1.06286222
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05661099
72	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.05145957
73	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.03451719
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.03250017
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02775443
76	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01996991
77	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00919301
78	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.00553910
79	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00512302
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99679527
81	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99414843
82	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99414843
83	MYC_19829295_ChIP-Seq_ESCs_Human	0.97527260
84	NCOR_22424771_ChIP-Seq_293T_Human	0.94415451
85	TP53_22573176_ChIP-Seq_HFKS_Human	0.94136829
86	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.93910330
87	TBL1_22424771_ChIP-Seq_293T_Human	0.92909238
88	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.91010043
89	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.90906803
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.88945735
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.87087255
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.86912798
93	ETV1_20927104_ChIP-Seq_GIST48_Human	0.86872874
94	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.86570047
95	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.86356029
96	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.86276231
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.86181779
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.86108575
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.85955567
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.84034499

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.48485415
2	MP0002254_reproductive_system_inflammat	4.22205398
3	MP0005410_abnormal_fertilization	3.72939311
4	MP0003718_maternal_effect	3.14729329
5	MP0008995_early_reproductive_senescence	2.94659302
6	MP0009697_abnormal_copulation	2.92473895
7	MP0008058_abnormal_DNA_repair	2.66194297
8	MP0001929_abnormal_gametogenesis	2.36794036
9	MP0002210_abnormal_sex_determination	2.28096665
10	MP0000383_abnormal_hair_follicle	2.26461658
11	MP0003698_abnormal_male_reproductive	2.24158718
12	MP0002736_abnormal_nociception_after	2.12254401
13	MP0001529_abnormal_vocalization	2.11721159
14	MP0001968_abnormal_touch/_nociception	2.04915759
15	MP0005377_hearing/vestibular/ear_phenot	2.00767026
16	MP0003878_abnormal_ear_physiology	2.00767026
17	MP0000569_abnormal_digit_pigmentation	2.00696979
18	MP0001346_abnormal_lacrimal_gland	1.80949635
19	MP0001145_abnormal_male_reproductive	1.80436229
20	MP0003136_yellow_coat_color	1.78219752
21	MP0000653_abnormal_sex_gland	1.77762804
22	MP0002876_abnormal_thyroid_physiology	1.73597517
23	MP0000427_abnormal_hair_cycle	1.73567985
24	MP0010678_abnormal_skin_adnexa	1.71344816
25	MP0006035_abnormal_mitochondrial_morpho	1.65594788
26	MP0006036_abnormal_mitochondrial_physio	1.62202379
27	MP0004043_abnormal_pH_regulation	1.62007143
28	MP0002102_abnormal_ear_morphology	1.60691706
29	MP0003786_premature_aging	1.58952183
30	MP0008872_abnormal_physiological_respon	1.52788706
31	MP0000647_abnormal_sebaceous_gland	1.52731464
32	MP0010094_abnormal_chromosome_stability	1.50642654
33	MP0002160_abnormal_reproductive_system	1.50028212
34	MP0006292_abnormal_olfactory_placode	1.45105060
35	MP0004215_abnormal_myocardial_fiber	1.43154330
36	MP0003937_abnormal_limbs/digits/tail_de	1.41529496
37	MP0003119_abnormal_digestive_system	1.37644546
38	MP0006276_abnormal_autonomic_nervous	1.37337972
39	MP0001905_abnormal_dopamine_level	1.37065348
40	MP0005647_abnormal_sex_gland	1.35817699
41	MP0003693_abnormal_embryo_hatching	1.34069861
42	MP0004147_increased_porphyrin_level	1.30647420
43	MP0003806_abnormal_nucleotide_metabolis	1.30405245
44	MP0008789_abnormal_olfactory_epithelium	1.22847605
45	MP0002161_abnormal_fertility/fecundity	1.21982924
46	MP0003950_abnormal_plasma_membrane	1.20491692
47	MP0005167_abnormal_blood-brain_barrier	1.16899464
48	MP0003186_abnormal_redox_activity	1.14900278
49	MP0003315_abnormal_perineum_morphology	1.14041945
50	MP0005395_other_phenotype	1.14035357
51	MP0003567_abnormal_fetal_cardiomyocyte	1.11347992
52	MP0005253_abnormal_eye_physiology	1.11047431
53	MP0002837_dystrophic_cardiac_calcinosis	1.10012283
54	MP0004084_abnormal_cardiac_muscle	1.08131111
55	MP0000749_muscle_degeneration	1.06513090
56	MP0000631_abnormal_neuroendocrine_gland	1.05489464
57	MP0002638_abnormal_pupillary_reflex	1.04995762
58	MP0000566_synostosis	1.00158608
59	MP0000678_abnormal_parathyroid_gland	0.98463745
60	MP0006072_abnormal_retinal_apoptosis	0.98450852
61	MP0005174_abnormal_tail_pigmentation	0.97814479
62	MP0000516_abnormal_urinary_system	0.96493073
63	MP0005367_renal/urinary_system_phenotyp	0.96493073
64	MP0001486_abnormal_startle_reflex	0.94490007
65	MP0003656_abnormal_erythrocyte_physiolo	0.94489104
66	MP0001119_abnormal_female_reproductive	0.88945924
67	MP0000537_abnormal_urethra_morphology	0.88754029
68	MP0003890_abnormal_embryonic-extraembry	0.88043021
69	MP0001293_anophthalmia	0.87849890
70	MP0010386_abnormal_urinary_bladder	0.87356633
71	MP0000462_abnormal_digestive_system	0.87043022
72	MP0005394_taste/olfaction_phenotype	0.86036086
73	MP0005499_abnormal_olfactory_system	0.86036086
74	MP0004019_abnormal_vitamin_homeostasis	0.85820229
75	MP0005389_reproductive_system_phenotype	0.85624026
76	MP0000538_abnormal_urinary_bladder	0.85221168
77	MP0000372_irregular_coat_pigmentation	0.84989542
78	MP0005646_abnormal_pituitary_gland	0.84914147
79	MP0004133_heterotaxia	0.83490007
80	MP0005551_abnormal_eye_electrophysiolog	0.83047208
81	MP0008057_abnormal_DNA_replication	0.82654343
82	MP0004036_abnormal_muscle_relaxation	0.81474827
83	MP0003880_abnormal_central_pattern	0.79679694
84	MP0008932_abnormal_embryonic_tissue	0.78402482
85	MP0001764_abnormal_homeostasis	0.77085622
86	MP0003938_abnormal_ear_development	0.76576137
87	MP0004957_abnormal_blastocyst_morpholog	0.76402795
88	MP0003787_abnormal_imprinting	0.76142484
89	MP0003699_abnormal_female_reproductive	0.73931708
90	MP0002084_abnormal_developmental_patter	0.72866778
91	MP0004142_abnormal_muscle_tone	0.71373782
92	MP0003646_muscle_fatigue	0.70527959
93	MP0002233_abnormal_nose_morphology	0.68909183
94	MP0003121_genomic_imprinting	0.68342659
95	MP0001730_embryonic_growth_arrest	0.67963907
96	MP0001348_abnormal_lacrimal_gland	0.67667409
97	MP0001697_abnormal_embryo_size	0.67452073
98	MP0002098_abnormal_vibrissa_morphology	0.65443056
99	MP0003385_abnormal_body_wall	0.65183624
100	MP0001984_abnormal_olfaction	0.64632987

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased circulating renin level (HP:0000848)	6.52692590
2	Tetany (HP:0001281)	4.72709749
3	Polydipsia (HP:0001959)	4.71875859
4	Abnormal drinking behavior (HP:0030082)	4.71875859
5	Hypomagnesemia (HP:0002917)	4.52893819
6	Hypokalemic alkalosis (HP:0001949)	4.44194276
7	Type II lissencephaly (HP:0007260)	4.08011029
8	Bilateral sensorineural hearing impairment (HP:0008619)	4.03526889
9	Cerebellar dysplasia (HP:0007033)	3.95343522
10	High anterior hairline (HP:0009890)	3.84584431
11	Tubulointerstitial nephritis (HP:0001970)	3.68933356
12	Abnormality of magnesium homeostasis (HP:0004921)	3.61863850
13	Polyuria (HP:0000103)	3.29763475
14	Long clavicles (HP:0000890)	3.17921258
15	Pancreatic fibrosis (HP:0100732)	3.04645000
16	Retinal atrophy (HP:0001105)	2.92203929
17	Asplenia (HP:0001746)	2.80537959
18	Abnormality of renin-angiotensin system (HP:0000847)	2.72276616
19	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.71287899
20	Abnormal urine output (HP:0012590)	2.62460612
21	Methylmalonic acidemia (HP:0002912)	2.55894403
22	Abnormality of the labia minora (HP:0012880)	2.52505128
23	Facial hemangioma (HP:0000329)	2.49514959
24	Retinal dysplasia (HP:0007973)	2.49165144
25	Amelogenesis imperfecta (HP:0000705)	2.47867782
26	Reduced antithrombin III activity (HP:0001976)	2.46334396
27	Supernumerary spleens (HP:0009799)	2.45695378
28	Pancreatic cysts (HP:0001737)	2.45469837
29	Fair hair (HP:0002286)	2.45260244
30	Abnormality of lateral ventricle (HP:0030047)	2.35314571
31	Abnormality of renal excretion (HP:0011036)	2.33924154
32	Hypoplasia of the uterus (HP:0000013)	2.32742367
33	Capillary hemangiomas (HP:0005306)	2.30982350
34	Paralysis (HP:0003470)	2.30434215
35	Abnormality of dental color (HP:0011073)	2.30399216
36	Birth length less than 3rd percentile (HP:0003561)	2.29471480
37	Hypokalemia (HP:0002900)	2.29449623
38	Ependymoma (HP:0002888)	2.28516604
39	Abnormality of the pons (HP:0007361)	2.25873308
40	Hypoplasia of the pons (HP:0012110)	2.23594430
41	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.21465176
42	Molar tooth sign on MRI (HP:0002419)	2.21459642
43	Abnormality of midbrain morphology (HP:0002418)	2.21459642
44	Hypoplastic iliac wings (HP:0002866)	2.20953255
45	Anterior segment dysgenesis (HP:0007700)	2.20241891
46	Type I transferrin isoform profile (HP:0003642)	2.19405253
47	Alkalosis (HP:0001948)	2.19313543
48	Conical tooth (HP:0000698)	2.16538470
49	Widely spaced teeth (HP:0000687)	2.11914020
50	Abnormality of permanent molar morphology (HP:0011071)	2.10219732
51	Abnormality of the dental root (HP:0006486)	2.10219732
52	Taurodontia (HP:0000679)	2.10219732
53	Partial agenesis of the corpus callosum (HP:0001338)	2.09687635
54	Clitoromegaly (HP:0000057)	2.04554377
55	Nephronophthisis (HP:0000090)	2.03094922
56	Abnormality of the renal cortex (HP:0011035)	2.03090214
57	Short 1st metacarpal (HP:0010034)	2.02441500
58	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.02441500
59	Abnormality of the renal medulla (HP:0100957)	1.98080979
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.97451673
61	Absent/shortened dynein arms (HP:0200106)	1.97451673
62	Methylmalonic aciduria (HP:0012120)	1.96489605
63	Abnormal respiratory motile cilium physiology (HP:0012261)	1.96200738
64	Tubulointerstitial abnormality (HP:0001969)	1.96170884
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.95161997
66	Abnormal protein N-linked glycosylation (HP:0012347)	1.95161997
67	Abnormal protein glycosylation (HP:0012346)	1.95161997
68	Abnormal glycosylation (HP:0012345)	1.95161997
69	Abnormality of molar (HP:0011077)	1.93846264
70	Abnormality of molar morphology (HP:0011070)	1.93846264
71	Absent speech (HP:0001344)	1.91785952
72	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91130510
73	Abnormal ciliary motility (HP:0012262)	1.90587674
74	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89804065
75	Abnormal biliary tract physiology (HP:0012439)	1.89413713
76	Bile duct proliferation (HP:0001408)	1.89413713
77	Median cleft lip (HP:0000161)	1.89090705
78	Anteriorly placed anus (HP:0001545)	1.84787671
79	Abnormality of the dental pulp (HP:0006479)	1.83969495
80	Abdominal situs inversus (HP:0003363)	1.83643313
81	Abnormality of abdominal situs (HP:0011620)	1.83643313
82	Hypoplasia of the fovea (HP:0007750)	1.83325410
83	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.83325410
84	Hyperlipoproteinemia (HP:0010980)	1.82263971
85	Hyperglycinemia (HP:0002154)	1.78648912
86	Cystic liver disease (HP:0006706)	1.76592696
87	Scotoma (HP:0000575)	1.75373001
88	Septate vagina (HP:0001153)	1.74766852
89	Severe muscular hypotonia (HP:0006829)	1.74066889
90	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.73034021
91	Abnormality of the ileum (HP:0001549)	1.72859093
92	Horseshoe kidney (HP:0000085)	1.72317398
93	Prolonged QT interval (HP:0001657)	1.71751903
94	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.71461263
95	Ectopic kidney (HP:0000086)	1.69311348
96	Abnormality of the 1st metacarpal (HP:0010009)	1.68793266
97	Hypoplastic nipples (HP:0002557)	1.68680255
98	Medial flaring of the eyebrow (HP:0010747)	1.68209804
99	Meckel diverticulum (HP:0002245)	1.65490846
100	Abnormality of potassium homeostasis (HP:0011042)	1.65349048

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	7.76368552
2	STK39	7.41264326
3	OXSR1	6.01765143
4	WNK3	4.37366294
5	PINK1	4.14281318
6	MAP2K7	2.34690840
7	MAP3K4	1.94642240
8	TNIK	1.84590414
9	CCNB1	1.74546114
10	PNCK	1.73240175
11	MARK3	1.69513143
12	ADRBK2	1.63424252
13	ZAK	1.55889308
14	PLK2	1.50789086
15	GRK1	1.38255494
16	PTK2B	1.36793726
17	NTRK3	1.31571247
18	TLK1	1.30412140
19	CDK3	1.23436836
20	FRK	1.20628726
21	PLK4	1.19124533
22	AKT3	0.91271959
23	OBSCN	0.89402333
24	EPHA4	0.86135196
25	RAF1	0.85636103
26	MAP3K2	0.82325351
27	RPS6KA5	0.81870632
28	KSR2	0.75332705
29	NEK2	0.74458497
30	MET	0.73158570
31	SRPK1	0.70929825
32	MAP3K6	0.67045462
33	BCKDK	0.66782338
34	BRSK2	0.66738092
35	PBK	0.66647505
36	TAOK3	0.64148629
37	PLK1	0.63812714
38	MARK1	0.63250884
39	DYRK3	0.61116938
40	PRKG2	0.60410519
41	MYLK	0.59059845
42	WEE1	0.58083563
43	NME1	0.57772222
44	PKN1	0.57118618
45	BMPR1B	0.56916897
46	STK16	0.55028100
47	CHEK2	0.54684798
48	NUAK1	0.51080642
49	MAP4K2	0.46998904
50	PHKG1	0.46565539
51	PHKG2	0.46565539
52	MKNK2	0.46090995
53	MAP3K13	0.44465768
54	KSR1	0.42661250
55	ATM	0.41362496
56	STK38L	0.41063429
57	TTK	0.39478355
58	CASK	0.38743618
59	PRKAA2	0.38207136
60	FGR	0.38104818
61	TRIM28	0.37870770
62	MAPK13	0.36319653
63	RPS6KA4	0.35510346
64	DMPK	0.34883862
65	CHEK1	0.34304623
66	MAP2K4	0.34179658
67	FGFR2	0.33565237
68	RET	0.33253764
69	PDK2	0.32272223
70	VRK1	0.31349222
71	BRAF	0.31170155
72	PRKG1	0.29828296
73	NEK6	0.29579304
74	GRK6	0.29279539
75	ILK	0.28213464
76	MAP3K8	0.26680592
77	FLT3	0.26464712
78	PRKAA1	0.26055531
79	ATR	0.25190877
80	AURKB	0.24657832
81	CAMK1G	0.24252620
82	MAP3K5	0.23936137
83	LATS1	0.23828380
84	PLK3	0.20737114
85	PRKCE	0.20517070
86	CDK1	0.20373361
87	BUB1	0.19048669
88	ERBB3	0.18051620
89	BMX	0.17716211
90	MAP3K7	0.17569644
91	MKNK1	0.17110234
92	MAP2K1	0.16413504
93	SGK2	0.16296417
94	PAK1	0.15894176
95	CAMK1	0.15056714
96	CSNK2A1	0.13060136
97	PRKCQ	0.12827113
98	PRKCZ	0.12774234
99	CDK19	0.12474412
100	PASK	0.11817915

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.22760272
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.00675399
3	Basal transcription factors_Homo sapiens_hsa03022	2.78795861
4	Collecting duct acid secretion_Homo sapiens_hsa04966	2.73315056
5	Olfactory transduction_Homo sapiens_hsa04740	2.57602957
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.52291624
7	Folate biosynthesis_Homo sapiens_hsa00790	2.28387188
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.15411868
9	RNA transport_Homo sapiens_hsa03013	2.15058798
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.15053425
11	Propanoate metabolism_Homo sapiens_hsa00640	2.11153815
12	Homologous recombination_Homo sapiens_hsa03440	2.10708321
13	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.01941223
14	DNA replication_Homo sapiens_hsa03030	1.90382595
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.81050338
16	Sulfur relay system_Homo sapiens_hsa04122	1.72722124
17	Mismatch repair_Homo sapiens_hsa03430	1.67685024
18	Oocyte meiosis_Homo sapiens_hsa04114	1.61898115
19	mRNA surveillance pathway_Homo sapiens_hsa03015	1.57023971
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.56439709
21	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.52869645
22	RNA degradation_Homo sapiens_hsa03018	1.48087706
23	RNA polymerase_Homo sapiens_hsa03020	1.45449056
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.44486008
25	Protein export_Homo sapiens_hsa03060	1.43248625
26	Arginine biosynthesis_Homo sapiens_hsa00220	1.42293675
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.40423631
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40363717
29	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.38825538
30	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.36770905
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35051691
32	Parkinsons disease_Homo sapiens_hsa05012	1.34360159
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.33966371
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.32305232
35	Gap junction_Homo sapiens_hsa04540	1.31622088
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.26819084
37	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.25359873
38	Fatty acid metabolism_Homo sapiens_hsa01212	1.19451006
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.16094213
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.13746195
41	Cell cycle_Homo sapiens_hsa04110	1.06911995
42	One carbon pool by folate_Homo sapiens_hsa00670	1.05277163
43	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.03327287
44	Phototransduction_Homo sapiens_hsa04744	1.03032058
45	Proteasome_Homo sapiens_hsa03050	1.02179890
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00572178
47	Peroxisome_Homo sapiens_hsa04146	0.99360421
48	Butanoate metabolism_Homo sapiens_hsa00650	0.95423247
49	Taste transduction_Homo sapiens_hsa04742	0.94046030
50	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92753477
51	Huntingtons disease_Homo sapiens_hsa05016	0.89209180
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88616284
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88394843
54	Purine metabolism_Homo sapiens_hsa00230	0.87137799
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86201753
56	Spliceosome_Homo sapiens_hsa03040	0.86057389
57	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85536004
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82772772
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81034591
60	Base excision repair_Homo sapiens_hsa03410	0.78679134
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.76464756
62	Vibrio cholerae infection_Homo sapiens_hsa05110	0.76389490
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73116941
64	Regulation of autophagy_Homo sapiens_hsa04140	0.72021634
65	Fatty acid elongation_Homo sapiens_hsa00062	0.66678647
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.66380906
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64801383
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64402659
69	Nicotine addiction_Homo sapiens_hsa05033	0.64244248
70	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.63467245
71	Glutathione metabolism_Homo sapiens_hsa00480	0.62751716
72	Metabolic pathways_Homo sapiens_hsa01100	0.62111537
73	ABC transporters_Homo sapiens_hsa02010	0.59230803
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56432045
75	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53097664
76	Fatty acid degradation_Homo sapiens_hsa00071	0.51016346
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50363192
78	Circadian entrainment_Homo sapiens_hsa04713	0.50049759
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50017520
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49561007
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.47403675
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45736821
83	Retinol metabolism_Homo sapiens_hsa00830	0.44745474
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.44357936
85	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.42204780
86	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41787534
87	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41642881
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40006122
89	Alcoholism_Homo sapiens_hsa05034	0.36331829
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.35694447
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35159380
92	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34985119
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33838253
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.33344577
95	Circadian rhythm_Homo sapiens_hsa04710	0.33063826
96	Alzheimers disease_Homo sapiens_hsa05010	0.31883289
97	mTOR signaling pathway_Homo sapiens_hsa04150	0.31144035
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30465065
99	Wnt signaling pathway_Homo sapiens_hsa04310	0.30196909
100	Carbon metabolism_Homo sapiens_hsa01200	0.27454878

CSNK1A1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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