CSNK1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.37141192
2embryonic process involved in female pregnancy (GO:0060136)6.15962470
3establishment of apical/basal cell polarity (GO:0035089)5.94997307
4regulation of integrin activation (GO:0033623)5.42405385
5establishment of monopolar cell polarity (GO:0061162)5.15031263
6establishment or maintenance of monopolar cell polarity (GO:0061339)5.15031263
7proline metabolic process (GO:0006560)4.99820104
8mannose metabolic process (GO:0006013)4.83007159
9positive regulation of protein homooligomerization (GO:0032464)4.82104553
10transcription from mitochondrial promoter (GO:0006390)4.66549856
11mitotic G1 DNA damage checkpoint (GO:0031571)4.64460996
12regulation of translational fidelity (GO:0006450)4.56397748
13regulation of protein homooligomerization (GO:0032462)4.53224350
14negative regulation of erythrocyte differentiation (GO:0045647)4.52600486
15GDP-mannose metabolic process (GO:0019673)4.42587920
16adenosine receptor signaling pathway (GO:0001973)4.40996163
17positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.38998243
18negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.34723845
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.14332900
20mitotic G1/S transition checkpoint (GO:0044819)4.04160968
21G1 DNA damage checkpoint (GO:0044783)4.02020056
22oxidative demethylation (GO:0070989)4.01579150
23dosage compensation (GO:0007549)3.98746359
24embryonic placenta development (GO:0001892)3.97842187
25spliceosomal tri-snRNP complex assembly (GO:0000244)3.92156439
26replication fork processing (GO:0031297)3.79826352
27regulation of early endosome to late endosome transport (GO:2000641)3.71877725
28semaphorin-plexin signaling pathway (GO:0071526)3.71695502
29protein localization to endosome (GO:0036010)3.68774624
30apoptotic process involved in morphogenesis (GO:0060561)3.65743795
31negative regulation of JAK-STAT cascade (GO:0046426)3.61929408
32regulation of RNA export from nucleus (GO:0046831)3.56804764
33signal complex assembly (GO:0007172)3.52985117
34protein carboxylation (GO:0018214)3.52269772
35peptidyl-glutamic acid carboxylation (GO:0017187)3.52269772
36nodal signaling pathway (GO:0038092)3.51663148
37anatomical structure regression (GO:0060033)3.48945186
38negative regulation of Ras GTPase activity (GO:0034261)3.46947640
39pre-miRNA processing (GO:0031054)3.45852837
40trophectodermal cell differentiation (GO:0001829)3.44658492
41negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.43487006
42mRNA cleavage (GO:0006379)3.41103660
43mitochondrial DNA metabolic process (GO:0032042)3.40858463
44regulation of hippo signaling (GO:0035330)3.39582552
45negative regulation of mRNA processing (GO:0050686)3.38391548
46negative regulation of protein oligomerization (GO:0032460)3.38325675
47negative regulation of RNA splicing (GO:0033119)3.34586668
48G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.34251027
49response to muramyl dipeptide (GO:0032495)3.33916043
50positive regulation of protein kinase C signaling (GO:0090037)3.30951242
51modulation by virus of host process (GO:0019054)3.26887333
52convergent extension (GO:0060026)3.26511338
53negative regulation of cell cycle arrest (GO:0071157)3.25650635
54polarized epithelial cell differentiation (GO:0030859)3.23826960
55regulation of sister chromatid cohesion (GO:0007063)3.20773384
56embryonic camera-type eye development (GO:0031076)3.18689868
57UV protection (GO:0009650)3.18580040
58cellular response to virus (GO:0098586)3.18194413
59regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.16650211
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16322895
61intracellular estrogen receptor signaling pathway (GO:0030520)3.15656099
62positive regulation of protein oligomerization (GO:0032461)3.15207965
63modulation by symbiont of host cellular process (GO:0044068)3.13283793
64face development (GO:0060324)3.11874922
65regulation of protein oligomerization (GO:0032459)3.08166083
66regulation of ARF GTPase activity (GO:0032312)3.08057341
67activation of Rac GTPase activity (GO:0032863)3.07949598
68poly(A)+ mRNA export from nucleus (GO:0016973)3.05151686
69negative regulation of mRNA metabolic process (GO:1903312)3.03070147
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.01171617
71regulation of nucleobase-containing compound transport (GO:0032239)3.01125135
72glial cell migration (GO:0008347)3.00742312
73regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00649492
74cellular response to ATP (GO:0071318)2.99460869
75response to peptidoglycan (GO:0032494)2.99311579
76negative regulation of toll-like receptor signaling pathway (GO:0034122)2.98078587
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98060861
78negative regulation of chondrocyte differentiation (GO:0032331)2.96753007
79regulation of podosome assembly (GO:0071801)2.93633113
80stress fiber assembly (GO:0043149)2.93264617
81response to laminar fluid shear stress (GO:0034616)2.92682183
82negative regulation of interleukin-8 production (GO:0032717)2.92491767
83protein heterotrimerization (GO:0070208)2.92008169
84adenine nucleotide transport (GO:0051503)2.89963041
85negative regulation of fatty acid biosynthetic process (GO:0045717)2.89763732
86maternal placenta development (GO:0001893)2.88305725
87negative regulation of cell aging (GO:0090344)2.88103992
88glutamine family amino acid biosynthetic process (GO:0009084)2.87022567
89regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.86360662
90establishment or maintenance of bipolar cell polarity (GO:0061245)2.84437858
91establishment or maintenance of apical/basal cell polarity (GO:0035088)2.84437858
92G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.83394268
93hypotonic response (GO:0006971)2.82196572
94antigen processing and presentation of endogenous antigen (GO:0019883)2.81069466
95basement membrane organization (GO:0071711)2.80800561
96protein retention in ER lumen (GO:0006621)2.80202574
97negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79754201
98negative regulation of cell killing (GO:0031342)2.79754201
99endothelial cell chemotaxis (GO:0035767)2.79594968
100focal adhesion assembly (GO:0048041)2.79547829
101cell-substrate adherens junction assembly (GO:0007045)2.79547829
102cell-cell junction maintenance (GO:0045217)2.78273724
103negative regulation of glial cell proliferation (GO:0060253)2.78106870
104endocytic recycling (GO:0032456)2.77802960
105negative regulation of cartilage development (GO:0061037)2.76704184
106heterochromatin organization (GO:0070828)2.75259262
107somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74888746
108somatic hypermutation of immunoglobulin genes (GO:0016446)2.74888746
109cellular response to zinc ion (GO:0071294)2.74191932
110regulation of cell size (GO:0008361)2.73966783
111positive thymic T cell selection (GO:0045059)2.73235286
112lens fiber cell differentiation (GO:0070306)2.72531032
113labyrinthine layer development (GO:0060711)2.69969649
114positive regulation by host of viral transcription (GO:0043923)2.69207765
115regulation of interferon-beta biosynthetic process (GO:0045357)2.68321983
116histone H4-K12 acetylation (GO:0043983)2.68157415
117peptidyl-lysine dimethylation (GO:0018027)2.67474525
118apoptotic process involved in development (GO:1902742)2.67177827
119planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66775332
120embryonic eye morphogenesis (GO:0048048)2.66650700
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66272695
122formation of translation preinitiation complex (GO:0001731)2.64897357
123actin filament bundle organization (GO:0061572)2.64728673
124actin filament bundle assembly (GO:0051017)2.64728673
125N-glycan processing (GO:0006491)2.63815101
126adherens junction assembly (GO:0034333)2.63660635
127atrioventricular valve morphogenesis (GO:0003181)2.63187616
128sensory perception of taste (GO:0050909)2.62555764
129NIK/NF-kappaB signaling (GO:0038061)2.62357584
130negative regulation of fatty acid transport (GO:2000192)2.62198434
131regulation of cytokine production involved in inflammatory response (GO:1900015)2.61521174
132positive regulation of lamellipodium assembly (GO:0010592)2.59918039
133cell migration in hindbrain (GO:0021535)2.59743290
134positive regulation of histone deacetylation (GO:0031065)2.59461377
135base-excision repair (GO:0006284)2.57742985
1363-UTR-mediated mRNA stabilization (GO:0070935)2.57617759
137regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56937043
138regulation of chromatin binding (GO:0035561)2.56278218
139negative regulation of nucleotide catabolic process (GO:0030812)2.55576063
140neural tube closure (GO:0001843)2.55488025
141regulation of cholesterol homeostasis (GO:2000188)2.55357157
142purine ribonucleotide transport (GO:0015868)2.55050206
143negative regulation of focal adhesion assembly (GO:0051895)2.54843049
144negative regulation of cell junction assembly (GO:1901889)2.54843049
145negative regulation of adherens junction organization (GO:1903392)2.54843049
146positive regulation by symbiont of host defense response (GO:0052509)2.54230181
147modulation by symbiont of host defense response (GO:0052031)2.54230181
148modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54230181
149modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54230181
150positive regulation by organism of defense response of other organism involved in symbiotic interact2.54230181
151modulation by symbiont of host immune response (GO:0052553)2.54230181
152regulation of DNA damage checkpoint (GO:2000001)2.54216641
153DNA strand renaturation (GO:0000733)2.53164763
154positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.52945082
155negative regulation of granulocyte differentiation (GO:0030853)2.52711453
156positive regulation of Cdc42 GTPase activity (GO:0043089)2.52536267
157regulation of gene silencing by RNA (GO:0060966)2.52532464
158regulation of posttranscriptional gene silencing (GO:0060147)2.52532464
159regulation of gene silencing by miRNA (GO:0060964)2.52532464
160regulation of NFAT protein import into nucleus (GO:0051532)2.52463952
161thymic T cell selection (GO:0045061)2.52173328
162negative regulation of cell size (GO:0045792)2.51806975
163regulation of extracellular matrix disassembly (GO:0010715)2.51318649
164purinergic nucleotide receptor signaling pathway (GO:0035590)2.50107377
165regulation of ARF protein signal transduction (GO:0032012)2.48411444
166regulation of skeletal muscle contraction (GO:0014819)2.45059974
167histone H4 deacetylation (GO:0070933)2.44346402
168modulation by virus of host morphology or physiology (GO:0019048)2.44237175
169regulation of mammary gland epithelial cell proliferation (GO:0033599)2.43131082
170negative regulation of viral release from host cell (GO:1902187)2.43118078
171antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.41332045
172response to ATP (GO:0033198)2.41220656
173regulation of histone H3-K27 methylation (GO:0061085)2.40594193
174histone H3-K36 demethylation (GO:0070544)2.38914686
175purinergic receptor signaling pathway (GO:0035587)2.37238783
176germinal center formation (GO:0002467)2.36879204
177macrophage activation involved in immune response (GO:0002281)2.34831885
178positive regulation of CREB transcription factor activity (GO:0032793)2.32461401
179purine nucleotide transport (GO:0015865)2.31121810
180regulation of synapse structural plasticity (GO:0051823)2.31079653
181negative regulation of tumor necrosis factor production (GO:0032720)2.30643588
182activation of JUN kinase activity (GO:0007257)2.29763027
183positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.28776870
184detection of bacterium (GO:0016045)2.27968186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09208539
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.98199127
3MYC_22102868_ChIP-Seq_BL_Human2.90945638
4* VDR_21846776_ChIP-Seq_THP-1_Human2.69237665
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.63730367
6* LXR_22292898_ChIP-Seq_THP-1_Human2.44083747
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34230624
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.32562524
9* KDM2B_26808549_Chip-Seq_DND41_Human2.31195029
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23976971
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.21312200
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19594343
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.17761225
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13853300
15ZNF263_19887448_ChIP-Seq_K562_Human2.12483924
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.12329520
17* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03946144
18TCF7_22412390_ChIP-Seq_EML_Mouse2.01103605
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.98405928
20RACK7_27058665_Chip-Seq_MCF-7_Human1.98213198
21* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.92798794
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91290500
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82862114
24KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81501754
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.75855595
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75526731
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75526731
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75526731
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75424271
30P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71680305
31SMC4_20622854_ChIP-Seq_HELA_Human1.71602889
32KDM2B_26808549_Chip-Seq_K562_Human1.69485454
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.69292850
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.68845387
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68826254
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66761479
37SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.65504632
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63069800
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.62346357
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60339306
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58510099
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.58295726
43BCL6_27268052_Chip-Seq_Bcells_Human1.55937755
44CTCF_27219007_Chip-Seq_Bcells_Human1.51938967
45POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51660479
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50897292
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48115391
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47626196
49* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46353523
50MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.45440508
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44136962
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43556232
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40956560
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40077482
55MAF_26560356_Chip-Seq_TH1_Human1.38866491
56* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38469416
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37272281
58E2F1_20622854_ChIP-Seq_HELA_Human1.37054295
59ATF3_27146783_Chip-Seq_COLON_Human1.36196308
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35673308
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35075273
62CREB1_26743006_Chip-Seq_LNCaP_Human1.34868061
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.34298453
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.33762165
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33746964
66PHF8_20622854_ChIP-Seq_HELA_Human1.33225746
67RARB_24833708_ChIP-Seq_LIVER_Mouse1.32970980
68UTX_26944678_Chip-Seq_JUKART_Human1.32121886
69CLOCK_20551151_ChIP-Seq_293T_Human1.31481926
70* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31466487
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31076087
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30934089
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30893806
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30725722
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29843953
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29457561
77RARA_24833708_ChIP-Seq_LIVER_Mouse1.28459777
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28067007
79VDR_24763502_ChIP-Seq_THP-1_Human1.27542202
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27241584
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25975133
82NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25712965
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24754027
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23862800
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23587581
86TRIM28_21343339_ChIP-Seq_HEK293_Human1.22621063
87CTCF_21964334_Chip-Seq_Bcells_Human1.22245054
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21878989
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.20233803
90* NCOR1_26117541_ChIP-Seq_K562_Human1.20186813
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.20029799
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19147390
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18730595
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17856590
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17721094
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16906678
97MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16810400
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16736504
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16727840
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16132501
101* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15881506
102TP53_22127205_ChIP-Seq_IMR90_Human1.14612643
103* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13564335
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12784945
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12287964
106SA1_27219007_Chip-Seq_Bcells_Human1.11990937
107* XRN2_22483619_ChIP-Seq_HELA_Human1.11589079
108P68_20966046_ChIP-Seq_HELA_Human1.10719347
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.10488803
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10057694
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09902258
112TP63_22573176_ChIP-Seq_HFKS_Human1.09730864
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09339323
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09244583
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09012736
116* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07740285
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07400185
118RUNX1_27514584_Chip-Seq_MCF-7_Human1.07141172
119* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06732815
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06438853
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04924371
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03856506
123* UBF1/2_26484160_Chip-Seq_HMECs_Human1.03582597
124* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03525572
125* GATA1_19941827_ChIP-Seq_MEL_Mouse1.03392440
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02955701
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02670157
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02464738
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01717642
130MAF_26560356_Chip-Seq_TH2_Human1.01249726
131FOXP1_21924763_ChIP-Seq_HESCs_Human1.00592074
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00559598
133BCOR_27268052_Chip-Seq_Bcells_Human1.00440903
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99841781
135* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99841247
136MYC_18555785_ChIP-Seq_MESCs_Mouse0.99601268
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98073639
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.97868973
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96865148
140* CHD1_26751641_Chip-Seq_LNCaP_Human0.96857696
141ETS1_21867929_ChIP-Seq_TH2_Mouse0.95559406
142SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95087821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.46003487
2MP0005409_darkened_coat_color3.92189380
3MP0010030_abnormal_orbit_morphology3.39342609
4MP0003705_abnormal_hypodermis_morpholog3.31392804
5MP0005076_abnormal_cell_differentiation3.24570736
6MP0004233_abnormal_muscle_weight3.11745840
7MP0001986_abnormal_taste_sensitivity3.11159710
8MP0010352_gastrointestinal_tract_polyps3.05420462
9MP0003283_abnormal_digestive_organ3.01520380
10MP0005423_abnormal_somatic_nervous2.82565816
11MP0003436_decreased_susceptibility_to2.72847377
12MP0008057_abnormal_DNA_replication2.42999366
13MP0001545_abnormal_hematopoietic_system2.12778091
14MP0005397_hematopoietic_system_phenotyp2.12778091
15MP0005451_abnormal_body_composition2.05103977
16MP0004381_abnormal_hair_follicle2.03324999
17MP0009840_abnormal_foam_cell2.01551377
18MP0003136_yellow_coat_color1.97914739
19MP0003566_abnormal_cell_adhesion1.89084367
20MP0003453_abnormal_keratinocyte_physiol1.89068423
21MP0003119_abnormal_digestive_system1.87541750
22MP0002653_abnormal_ependyma_morphology1.82935979
23MP0000751_myopathy1.81808052
24MP0005083_abnormal_biliary_tract1.80630352
25MP0001958_emphysema1.79080693
26MP0001188_hyperpigmentation1.71844462
27MP0002084_abnormal_developmental_patter1.70793436
28MP0002086_abnormal_extraembryonic_tissu1.70133247
29MP0002009_preneoplasia1.68325417
30MP0002282_abnormal_trachea_morphology1.65745125
31MP0001849_ear_inflammation1.64799888
32MP0008260_abnormal_autophagy1.61896925
33MP0005171_absent_coat_pigmentation1.59469121
34MP0000678_abnormal_parathyroid_gland1.58050425
35* MP0004197_abnormal_fetal_growth/weight/1.58018359
36MP0000750_abnormal_muscle_regeneration1.54201066
37MP0009053_abnormal_anal_canal1.53934262
38MP0003890_abnormal_embryonic-extraembry1.53664461
39MP0003300_gastrointestinal_ulcer1.50029814
40MP0004947_skin_inflammation1.47290551
41MP0010234_abnormal_vibrissa_follicle1.46908888
42MP0001873_stomach_inflammation1.46535809
43MP0001697_abnormal_embryo_size1.45875283
44MP0003045_fibrosis1.45532224
45MP0000858_altered_metastatic_potential1.45521832
46MP0005023_abnormal_wound_healing1.44299177
47MP0003567_abnormal_fetal_cardiomyocyte1.43739982
48MP0005257_abnormal_intraocular_pressure1.43184560
49MP0002085_abnormal_embryonic_tissue1.41569978
50MP0000733_abnormal_muscle_development1.40568357
51MP0005623_abnormal_meninges_morphology1.39419436
52MP0002877_abnormal_melanocyte_morpholog1.30509653
53MP0004185_abnormal_adipocyte_glucose1.29261237
54MP0003172_abnormal_lysosome_physiology1.29204405
55MP0005375_adipose_tissue_phenotype1.26291927
56MP0002249_abnormal_larynx_morphology1.23586229
57MP0001730_embryonic_growth_arrest1.23327374
58MP0001672_abnormal_embryogenesis/_devel1.23183453
59MP0005380_embryogenesis_phenotype1.23183453
60MP0010307_abnormal_tumor_latency1.22951219
61MP0005666_abnormal_adipose_tissue1.21592901
62MP0000462_abnormal_digestive_system1.21150249
63MP0003385_abnormal_body_wall1.20713676
64MP0003329_amyloid_beta_deposits1.20602759
65MP0004264_abnormal_extraembryonic_tissu1.19948818
66MP0000537_abnormal_urethra_morphology1.18639718
67MP0002796_impaired_skin_barrier1.17848377
68MP0002932_abnormal_joint_morphology1.17668383
69MP0000350_abnormal_cell_proliferation1.17479077
70MP0005025_abnormal_response_to1.16740515
71MP0003279_aneurysm1.15850811
72MP0009333_abnormal_splenocyte_physiolog1.15487233
73MP0008995_early_reproductive_senescence1.15281530
74MP0008438_abnormal_cutaneous_collagen1.14560041
75MP0003191_abnormal_cellular_cholesterol1.14258547
76MP0010155_abnormal_intestine_physiology1.14246549
77MP0002419_abnormal_innate_immunity1.13691457
78MP0000015_abnormal_ear_pigmentation1.12564113
79MP0003984_embryonic_growth_retardation1.11137939
80MP0003115_abnormal_respiratory_system1.11013910
81MP0003763_abnormal_thymus_physiology1.11002431
82MP0002088_abnormal_embryonic_growth/wei1.10695032
83MP0002269_muscular_atrophy1.08745210
84MP0000685_abnormal_immune_system1.07884290
85MP0002060_abnormal_skin_morphology1.07783320
86MP0001293_anophthalmia1.07719384
87MP0003303_peritoneal_inflammation1.07489679
88MP0003935_abnormal_craniofacial_develop1.06291807
89MP0000579_abnormal_nail_morphology1.05851267
90MP0002998_abnormal_bone_remodeling1.05192529
91MP0003091_abnormal_cell_migration1.04928970
92* MP0002080_prenatal_lethality1.04573017
93MP0010630_abnormal_cardiac_muscle1.04409309
94MP0008961_abnormal_basal_metabolism1.03994138
95MP0000490_abnormal_crypts_of1.03941781
96MP0001756_abnormal_urination1.03883699
97MP0002111_abnormal_tail_morphology1.03289439
98MP0000747_muscle_weakness1.03039690
99MP0000371_diluted_coat_color1.02993511
100MP0002089_abnormal_postnatal_growth/wei1.02516593
101MP0002933_joint_inflammation1.01964282
102MP0004133_heterotaxia1.01856568
103MP0005058_abnormal_lysosome_morphology1.01513158
104MP0005330_cardiomyopathy1.01446534
105MP0001533_abnormal_skeleton_physiology1.00824178
106MP0005501_abnormal_skin_physiology0.99243891
107MP0002925_abnormal_cardiovascular_devel0.97669067
108MP0003448_altered_tumor_morphology0.97339196
109MP0009931_abnormal_skin_appearance0.95655955
110MP0004510_myositis0.94864814
111MP0003942_abnormal_urinary_system0.94430663
112MP0000467_abnormal_esophagus_morphology0.93323587
113MP0001340_abnormal_eyelid_morphology0.93233692
114MP0001790_abnormal_immune_system0.93163878
115MP0005387_immune_system_phenotype0.93163878
116MP0005508_abnormal_skeleton_morphology0.92536144
117MP0004957_abnormal_blastocyst_morpholog0.91291194
118MP0003183_abnormal_peptide_metabolism0.90758930
119MP0002166_altered_tumor_susceptibility0.89304679
120MP0005000_abnormal_immune_tolerance0.89247752
121MP0002254_reproductive_system_inflammat0.88737445
122MP0000534_abnormal_ureter_morphology0.88641908
123MP0002723_abnormal_immune_serum0.88202311
124MP0001348_abnormal_lacrimal_gland0.86737936
125MP0000767_abnormal_smooth_muscle0.86726575
126MP0000013_abnormal_adipose_tissue0.85920321
127MP0010094_abnormal_chromosome_stability0.85010409
128MP0006072_abnormal_retinal_apoptosis0.85009800
129MP0005248_abnormal_Harderian_gland0.84322059
130MP0009115_abnormal_fat_cell0.84054329
131MP0000477_abnormal_intestine_morphology0.83191697
132MP0003828_pulmonary_edema0.82915541
133MP0002452_abnormal_antigen_presenting0.82217996
134MP0000470_abnormal_stomach_morphology0.82132509
135MP0001915_intracranial_hemorrhage0.82017892
136MP0005367_renal/urinary_system_phenotyp0.81656604
137MP0000516_abnormal_urinary_system0.81656604
138MP0001800_abnormal_humoral_immune0.80685690
139MP0000003_abnormal_adipose_tissue0.80655931
140MP0000428_abnormal_craniofacial_morphol0.80232646
141MP0006082_CNS_inflammation0.79687407
142MP0001784_abnormal_fluid_regulation0.79388184
143MP0002019_abnormal_tumor_incidence0.79158920
144MP0002116_abnormal_craniofacial_bone0.79076459
145MP0001819_abnormal_immune_cell0.78916064
146MP0002420_abnormal_adaptive_immunity0.78516201
147MP0005174_abnormal_tail_pigmentation0.78454437
148MP0002405_respiratory_system_inflammati0.78322467
149MP0002697_abnormal_eye_size0.77411426
150MP0004130_abnormal_muscle_cell0.77004021
151MP0001765_abnormal_ion_homeostasis0.76942902
152MP0008770_decreased_survivor_rate0.76711148
153MP0004858_abnormal_nervous_system0.75823465
154MP0000538_abnormal_urinary_bladder0.75599886
155MP0003755_abnormal_palate_morphology0.75506323
156MP0002398_abnormal_bone_marrow0.74594422
157MP0005584_abnormal_enzyme/coenzyme_acti0.71195301
158MP0003724_increased_susceptibility_to0.71082247
159MP0005621_abnormal_cell_physiology0.69999027
160MP0000716_abnormal_immune_system0.69744588
161MP0002429_abnormal_blood_cell0.68877421
162MP0001216_abnormal_epidermal_layer0.68399820
163MP0001661_extended_life_span0.68325088
164MP0004782_abnormal_surfactant_physiolog0.68042024
165MP0000703_abnormal_thymus_morphology0.66461147
166MP0000367_abnormal_coat/_hair0.65735995
167MP0001835_abnormal_antigen_presentation0.65258921
168MP0005365_abnormal_bile_salt0.64413999
169MP0002896_abnormal_bone_mineralization0.64081212
170MP0009384_cardiac_valve_regurgitation0.63843532

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)5.09896561
2Cerebral aneurysm (HP:0004944)4.27828829
3Annular pancreas (HP:0001734)4.20419728
4Turricephaly (HP:0000262)4.11189663
5Testicular atrophy (HP:0000029)4.08357258
6Ulnar bowing (HP:0003031)4.05133879
7Hemorrhage of the eye (HP:0011885)4.01158067
8Alopecia of scalp (HP:0002293)3.33265185
9Facial hemangioma (HP:0000329)3.32025507
10Pustule (HP:0200039)3.24812160
11Rib fusion (HP:0000902)3.22159533
12Poikiloderma (HP:0001029)3.13288798
13Coronal craniosynostosis (HP:0004440)3.07893772
14Male infertility (HP:0003251)3.04947237
15Protrusio acetabuli (HP:0003179)2.81173620
16Hypercortisolism (HP:0001578)2.80281578
17Hyperacusis (HP:0010780)2.72952585
18Concave nail (HP:0001598)2.72280590
19Joint hemorrhage (HP:0005261)2.68105687
20Obstructive sleep apnea (HP:0002870)2.65625229
21Akinesia (HP:0002304)2.63903897
22Broad face (HP:0000283)2.63242539
23Polycythemia (HP:0001901)2.59920812
24Bowed forearm bones (HP:0003956)2.58879215
25Bowing of the arm (HP:0006488)2.58879215
26Mucopolysacchariduria (HP:0008155)2.58494712
27Urinary glycosaminoglycan excretion (HP:0003541)2.58494712
28Cervical subluxation (HP:0003308)2.57326608
29Congenital hip dislocation (HP:0001374)2.53684266
30Thin ribs (HP:0000883)2.51542472
31Popliteal pterygium (HP:0009756)2.50958360
32Myopathic facies (HP:0002058)2.50654264
33Vertebral hypoplasia (HP:0008417)2.50423182
34Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.50423182
35Short humerus (HP:0005792)2.49566394
36Orthostatic hypotension (HP:0001278)2.47046675
37Delayed epiphyseal ossification (HP:0002663)2.40711496
38Abnormality of the fingertips (HP:0001211)2.40404708
39Growth hormone excess (HP:0000845)2.38985546
40Shallow orbits (HP:0000586)2.33590296
41Abnormality of polysaccharide metabolism (HP:0011012)2.31520407
42Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31520407
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31520407
44Eczematoid dermatitis (HP:0000976)2.30356563
45Aplasia of the musculature (HP:0100854)2.28875943
46Mesangial abnormality (HP:0001966)2.28022421
47Easy fatigability (HP:0003388)2.27628965
48Abnormality of the aortic arch (HP:0012303)2.23438977
49Basal cell carcinoma (HP:0002671)2.22785992
50Gastrointestinal infarctions (HP:0005244)2.19773815
51Aplasia/hypoplasia of the humerus (HP:0006507)2.19208822
52Abnormality of the intrinsic pathway (HP:0010989)2.18370477
53Muscle fibrillation (HP:0010546)2.18102111
54Abnormality of the lower motor neuron (HP:0002366)2.17485264
55Abnormality of the costochondral junction (HP:0000919)2.16413403
56Abnormality of the astrocytes (HP:0100707)2.16323020
57Astrocytoma (HP:0009592)2.16323020
58Heterotopia (HP:0002282)2.15519115
59Genu recurvatum (HP:0002816)2.15389726
60Dysostosis multiplex (HP:0000943)2.15194724
61Renal duplication (HP:0000075)2.13434768
62Increased IgM level (HP:0003496)2.11698792
63Intestinal fistula (HP:0100819)2.10849637
64Tongue fasciculations (HP:0001308)2.10167390
65Widely patent fontanelles and sutures (HP:0004492)2.10166000
66Selective tooth agenesis (HP:0001592)2.09406130
67Rectovaginal fistula (HP:0000143)2.09402790
68Rectal fistula (HP:0100590)2.09402790
69Anteriorly placed anus (HP:0001545)2.07176968
70Aneurysm (HP:0002617)2.05590509
71Vaginal fistula (HP:0004320)2.05172902
72Premature skin wrinkling (HP:0100678)2.03677611
73Facial diplegia (HP:0001349)2.03625319
74Broad alveolar ridges (HP:0000187)2.03465610
75Macroorchidism (HP:0000053)2.03139892
76Joint stiffness (HP:0001387)2.01884742
77Malnutrition (HP:0004395)2.01798695
78Asymmetric septal hypertrophy (HP:0001670)2.01206953
79Vertebral fusion (HP:0002948)1.97908246
80Emphysema (HP:0002097)1.97887711
81Abnormal hemoglobin (HP:0011902)1.97372037
82Hypochromic microcytic anemia (HP:0004840)1.95724099
83Atrioventricular block (HP:0001678)1.95256132
84Large for gestational age (HP:0001520)1.94863808
85Dislocated radial head (HP:0003083)1.93390335
86Short 5th finger (HP:0009237)1.91611942
87Broad thumb (HP:0011304)1.91175542
88Dyschromatopsia (HP:0007641)1.91084962
89Distal upper limb amyotrophy (HP:0007149)1.90481241
90Upper limb amyotrophy (HP:0009129)1.90481241
91Short 4th metacarpal (HP:0010044)1.90098470
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90098470
93Rectal prolapse (HP:0002035)1.89792543
94Fetal akinesia sequence (HP:0001989)1.89689944
95Segmental peripheral demyelination/remyelination (HP:0003481)1.89460500
96Long palpebral fissure (HP:0000637)1.88509435
97Congenital glaucoma (HP:0001087)1.88296008
98Volvulus (HP:0002580)1.87868812
99Disproportionate tall stature (HP:0001519)1.86679622
100Cheilitis (HP:0100825)1.86046213
101Vertebral compression fractures (HP:0002953)1.85781335
102Hypotrichosis (HP:0001006)1.85537076
103Hamartoma (HP:0010566)1.85158666
104Short chin (HP:0000331)1.84854168
105Hand muscle atrophy (HP:0009130)1.83633832
106Aortic aneurysm (HP:0004942)1.83350599
107Squamous cell carcinoma (HP:0002860)1.83245459
108Distal lower limb amyotrophy (HP:0008944)1.83240957
109Split hand (HP:0001171)1.82400317
110Mitral valve prolapse (HP:0001634)1.79904957
111Abnormality of the radial head (HP:0003995)1.78454361
112Choanal stenosis (HP:0000452)1.77938719
113Alacrima (HP:0000522)1.77111294
114Atelectasis (HP:0100750)1.76820292
115Hypotelorism (HP:0000601)1.76102965
116Zonular cataract (HP:0010920)1.75467379
117Arterial tortuosity (HP:0005116)1.75210140
118Spina bifida occulta (HP:0003298)1.74835569
119Hypertriglyceridemia (HP:0002155)1.74733730
120Capillary hemangiomas (HP:0005306)1.74552771
121Nasal polyposis (HP:0100582)1.74262944
122Flat acetabular roof (HP:0003180)1.74001009
123Narrow nasal bridge (HP:0000446)1.73471169
124Mitral regurgitation (HP:0001653)1.73270323
125Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.73124843
126Supernumerary nipples (HP:0002558)1.72800208
127Abnormality of the nasal mucosa (HP:0000433)1.72739835
128Premature rupture of membranes (HP:0001788)1.72736712
129Bladder diverticulum (HP:0000015)1.72145455
130Enlarged epiphyses (HP:0010580)1.72010683
131Renovascular hypertension (HP:0100817)1.70809386
132Elfin facies (HP:0004428)1.70419613
133Biconcave vertebral bodies (HP:0004586)1.70253049
134Increased CSF protein (HP:0002922)1.69810716
135Flat occiput (HP:0005469)1.69329539
136Broad palm (HP:0001169)1.68816148
137Abnormality of the 4th metacarpal (HP:0010012)1.67525205
138Ankle contracture (HP:0006466)1.67423153
139Insomnia (HP:0100785)1.67359307
140Germ cell neoplasia (HP:0100728)1.67143374
141Bowel diverticulosis (HP:0005222)1.67133666
142Difficulty climbing stairs (HP:0003551)1.67103580
143Wide cranial sutures (HP:0010537)1.66845158
144Prolonged partial thromboplastin time (HP:0003645)1.66548738
145Abnormality of the common coagulation pathway (HP:0010990)1.66212433
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.66186201
147Attenuation of retinal blood vessels (HP:0007843)1.65973851
148Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65216421
149Bilateral sensorineural hearing impairment (HP:0008619)1.65110208
150Deviation of the hallux (HP:0010051)1.64915971
151Metaphyseal cupping (HP:0003021)1.64803102
152Pseudobulbar signs (HP:0002200)1.64746393
153Pancreatic islet-cell hyperplasia (HP:0004510)1.64695320
154Dilatation of the ascending aorta (HP:0005111)1.64224480
155Hallux valgus (HP:0001822)1.63901156
156Gastrointestinal dysmotility (HP:0002579)1.63174479
157Hyperparathyroidism (HP:0000843)1.63171281
158Achilles tendon contracture (HP:0001771)1.61652239
159Vascular tortuosity (HP:0004948)1.61578938
160Abnormality of macrophages (HP:0004311)1.59648681
161Hypertensive crisis (HP:0100735)1.57627652
162Asymmetry of the thorax (HP:0001555)1.57205793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.06586799
2DDR24.36774945
3TRIB33.57376311
4MAPK152.99750780
5TYRO32.88479181
6PDGFRA2.80249903
7MAP3K62.76131473
8SMG12.67733157
9PRPF4B2.63837871
10BMX2.45159366
11MAP3K102.36804740
12MAP3K112.36348634
13MATK2.22800227
14PKN22.16967719
15EEF2K2.13582135
16RIPK11.98175591
17DYRK1B1.95177930
18FGR1.77182222
19PRKD21.76213560
20BLK1.74017318
21UHMK11.64600600
22CSK1.62794203
23LATS21.62506709
24CDK61.55289566
25IRAK31.47581348
26GRK61.46643786
27DAPK11.43903084
28PINK11.42017217
29TESK21.36894409
30CDK121.34413021
31MARK21.33510551
32PIM21.29422507
33ERN11.27424073
34MTOR1.24067800
35RIPK41.23456179
36MAP3K131.23408886
37PDPK11.23389742
38MAP3K31.20651623
39SIK11.10343126
40CDC42BPA1.09251225
41SIK31.08642421
42RPS6KA21.08091289
43PTK61.07796929
44IRAK41.07709086
45LATS11.04680631
46ALK1.03903321
47TAOK11.03549582
48CDK71.01516111
49WNK41.00212476
50PIM10.98295698
51MST1R0.98228641
52PAK20.96167342
53PDGFRB0.94404058
54TYK20.94203215
55TRPM70.93379594
56TTN0.92136489
57RPS6KB20.92121035
58RPS6KL10.91832760
59RPS6KC10.91832760
60IRAK20.91708814
61MAP3K10.91445190
62PTK20.90380425
63PAK40.87243519
64MAP3K140.86433830
65GSK3A0.85933801
66MAP3K90.85709495
67HIPK20.85566202
68MAPK110.83806968
69TAOK20.83167228
70ARAF0.80991174
71RPS6KA60.79848369
72LRRK20.78888112
73YES10.74104337
74MAP3K70.73435630
75FGFR40.72964081
76EPHB10.72680724
77WNK10.72037684
78SCYL20.70470678
79RPS6KA10.69827945
80PRKD30.69702869
81MAPK120.69702331
82MAP2K20.68693319
83FGFR10.67479337
84JAK30.65130698
85TNK20.63406476
86NTRK10.62344542
87PDK10.62316999
88PHKG10.60759580
89PHKG20.60759580
90MAP2K60.59205806
91KSR20.58862716
92NEK10.58745945
93NEK20.58392845
94STK100.56784620
95FLT30.56643420
96MAP4K10.55965502
97DMPK0.55834186
98IKBKE0.55552989
99SIK20.54701926
100FGFR30.52915224
101STK30.52747738
102EGFR0.52123189
103RET0.50933837
104PRKAA10.49908456
105CAMKK10.49083369
106EPHA20.48117599
107SGK30.46342866
108EPHB20.45223919
109MELK0.44845332
110MAPKAPK30.44503031
111MUSK0.43967426
112HCK0.43482236
113PAK60.42471151
114MAP3K80.42197721
115DYRK30.40090804
116TGFBR10.39894104
117JAK10.39709382
118STK380.39609855
119CDK40.38504436
120JAK20.38143788
121PRKCH0.37890881
122NME20.37038828
123BTK0.36883403
124MAPK70.36411996
125MAPK80.36314581
126MAPK10.36230137
127BRD40.35494776
128FER0.35355241
129CAMK1D0.34476215
130CDK20.33830340
131PRKD10.32806945
132ILK0.31793040
133RAF10.31464918
134CHUK0.30087649
135INSR0.29696303
136ERBB20.29478436
137CHEK20.28543441
138TESK10.27928408
139MAP2K30.27284517
140MAPKAPK20.26689062
141EPHA30.26280921
142ZAP700.25400669
143TGFBR20.25213909
144TBK10.25160181
145MAPK30.24445958

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.23981395
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.10512160
3Other glycan degradation_Homo sapiens_hsa005112.75192858
4mTOR signaling pathway_Homo sapiens_hsa041502.52125547
5Notch signaling pathway_Homo sapiens_hsa043302.16026960
6Adherens junction_Homo sapiens_hsa045202.13983397
7Chronic myeloid leukemia_Homo sapiens_hsa052202.04513209
8Base excision repair_Homo sapiens_hsa034102.03944890
9Bladder cancer_Homo sapiens_hsa052191.95640227
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.92676698
11* Hippo signaling pathway_Homo sapiens_hsa043901.89142394
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76795028
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70537006
14VEGF signaling pathway_Homo sapiens_hsa043701.68994878
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58758769
16Mismatch repair_Homo sapiens_hsa034301.56404890
17Longevity regulating pathway - mammal_Homo sapiens_hsa042111.52659248
18Shigellosis_Homo sapiens_hsa051311.49893843
19Basal cell carcinoma_Homo sapiens_hsa052171.48694443
20Proteoglycans in cancer_Homo sapiens_hsa052051.47946579
21Colorectal cancer_Homo sapiens_hsa052101.45785231
22Lysine degradation_Homo sapiens_hsa003101.41125863
23MicroRNAs in cancer_Homo sapiens_hsa052061.37838382
24Acute myeloid leukemia_Homo sapiens_hsa052211.37658318
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.37489720
26Small cell lung cancer_Homo sapiens_hsa052221.32952252
27TGF-beta signaling pathway_Homo sapiens_hsa043501.32433209
28mRNA surveillance pathway_Homo sapiens_hsa030151.32378615
29Dorso-ventral axis formation_Homo sapiens_hsa043201.30308292
30Focal adhesion_Homo sapiens_hsa045101.30046548
31Endometrial cancer_Homo sapiens_hsa052131.29333714
32Hepatitis C_Homo sapiens_hsa051601.24741918
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21215688
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20730944
35Thyroid cancer_Homo sapiens_hsa052161.20455285
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19411654
37Viral myocarditis_Homo sapiens_hsa054161.16977543
38Wnt signaling pathway_Homo sapiens_hsa043101.16430117
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15057853
40* Hedgehog signaling pathway_Homo sapiens_hsa043401.14787258
41TNF signaling pathway_Homo sapiens_hsa046681.14776935
42Pancreatic cancer_Homo sapiens_hsa052121.12195542
43DNA replication_Homo sapiens_hsa030301.11088425
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10283597
45Lysosome_Homo sapiens_hsa041421.10230193
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08697206
47Insulin signaling pathway_Homo sapiens_hsa049101.06910321
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06808198
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06753305
50p53 signaling pathway_Homo sapiens_hsa041151.06453574
51Leishmaniasis_Homo sapiens_hsa051401.06082992
52Inositol phosphate metabolism_Homo sapiens_hsa005621.05431346
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04804087
54Tight junction_Homo sapiens_hsa045301.02477703
55AMPK signaling pathway_Homo sapiens_hsa041521.02455709
56ErbB signaling pathway_Homo sapiens_hsa040121.02171871
57Glioma_Homo sapiens_hsa052140.99050944
58T cell receptor signaling pathway_Homo sapiens_hsa046600.98733313
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.98607627
60Influenza A_Homo sapiens_hsa051640.98472377
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98273601
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.97422897
63Biosynthesis of amino acids_Homo sapiens_hsa012300.96332354
64Estrogen signaling pathway_Homo sapiens_hsa049150.95959188
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94687169
66Non-small cell lung cancer_Homo sapiens_hsa052230.94624407
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.93791405
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93703405
69Tuberculosis_Homo sapiens_hsa051520.92473202
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.92195022
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92074582
72B cell receptor signaling pathway_Homo sapiens_hsa046620.90745523
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89250100
74Sphingolipid metabolism_Homo sapiens_hsa006000.86592631
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86573384
76Prolactin signaling pathway_Homo sapiens_hsa049170.83714724
77Viral carcinogenesis_Homo sapiens_hsa052030.83383176
78HIF-1 signaling pathway_Homo sapiens_hsa040660.82830721
79HTLV-I infection_Homo sapiens_hsa051660.82727329
80Endocytosis_Homo sapiens_hsa041440.82385683
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81358875
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79961138
83Hepatitis B_Homo sapiens_hsa051610.79702701
84Choline metabolism in cancer_Homo sapiens_hsa052310.79451287
85RNA transport_Homo sapiens_hsa030130.79063045
86Oocyte meiosis_Homo sapiens_hsa041140.78241838
87Chemokine signaling pathway_Homo sapiens_hsa040620.76878799
88Spliceosome_Homo sapiens_hsa030400.76422519
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.75485074
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73964181
91Legionellosis_Homo sapiens_hsa051340.73344690
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72616923
93Insulin resistance_Homo sapiens_hsa049310.71874091
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70911726
95Pathways in cancer_Homo sapiens_hsa052000.70748512
96Measles_Homo sapiens_hsa051620.70349172
97Rap1 signaling pathway_Homo sapiens_hsa040150.70315882
98Sulfur relay system_Homo sapiens_hsa041220.69296338
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.69047540
100Renal cell carcinoma_Homo sapiens_hsa052110.68382807
101Prostate cancer_Homo sapiens_hsa052150.68088720
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.67580703
103MAPK signaling pathway_Homo sapiens_hsa040100.67345756
104Cell cycle_Homo sapiens_hsa041100.67282225
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66981360
106Pertussis_Homo sapiens_hsa051330.65110851
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64085589
108Galactose metabolism_Homo sapiens_hsa000520.63830447
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63758448
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62750124
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62712655
112Staphylococcus aureus infection_Homo sapiens_hsa051500.62606635
113Amoebiasis_Homo sapiens_hsa051460.62249733
114Herpes simplex infection_Homo sapiens_hsa051680.61490545
115Salmonella infection_Homo sapiens_hsa051320.61322679
116Vitamin digestion and absorption_Homo sapiens_hsa049770.60486095
117Platelet activation_Homo sapiens_hsa046110.60261951
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59437418
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58320079
120ECM-receptor interaction_Homo sapiens_hsa045120.57747630
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.56969054
122Apoptosis_Homo sapiens_hsa042100.56530443
123GnRH signaling pathway_Homo sapiens_hsa049120.56338329
124Malaria_Homo sapiens_hsa051440.54942871
125* Gap junction_Homo sapiens_hsa045400.54103103
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53544597
127Toxoplasmosis_Homo sapiens_hsa051450.53153402
128Prion diseases_Homo sapiens_hsa050200.51757224
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.50663945
130Arginine and proline metabolism_Homo sapiens_hsa003300.50646164
131Glucagon signaling pathway_Homo sapiens_hsa049220.50401766
132FoxO signaling pathway_Homo sapiens_hsa040680.50077565
133Arginine biosynthesis_Homo sapiens_hsa002200.50047114
134Nitrogen metabolism_Homo sapiens_hsa009100.49066445
135Melanogenesis_Homo sapiens_hsa049160.49037319
136Osteoclast differentiation_Homo sapiens_hsa043800.48935086
137Fatty acid metabolism_Homo sapiens_hsa012120.48804039
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.47632150
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47623350
140Fructose and mannose metabolism_Homo sapiens_hsa000510.45601932
141Long-term potentiation_Homo sapiens_hsa047200.42669151

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